3,521 results match your criteria Amebic Hepatic Abscesses


CT of amebic liver abscess: different morphological types with different clinical features.

Abdom Radiol (NY) 2021 Apr 24. Epub 2021 Apr 24.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, India.

Purpose: To identify different morphological types of amebic liver abscess (ALA) based on CT findings and to assess whether they have different clinical features.

Method: CT images of 112 symptomatic patients with ALA were analyzed to identify the imaging features distinctive of each morphological type. The following CT findings were investigated: the presence of abscess wall, rim enhancement, edge characteristic, septa, intermediate density zone, and peripheral hypodensity. Read More

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Liver Abscess in Children-experience From a Single Tertiary Care Center of North India: Etiology, Clinical Profile and Predictors of Complications.

Pediatr Infect Dis J 2021 May;40(5):e179-e184

Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Liver abscess (LA), a common problem in children in the tropics, is believed to be mostly pyogenic (PLA), sometimes amebic (ALA). We aimed to analyze the clinical profile, etiology, risk factors for complications, management and outcomes of LA in children.

Methods: The details of 81 children with LA managed in a tertiary set up over a period of 3 years were analyzed. Read More

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Evaluation of the PEIII-LC3-KDEL3 Chimeric Protein of Lectin as a Vaccine Candidate against Amebic Liver Abscess.

J Immunol Res 2021 20;2021:6697900. Epub 2021 Mar 20.

Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, C. P. 20131., Aguascalientes, Ags., Mexico.

is an intestinal parasite that causes dysentery and amebic liver abscess. has the capability to invade host tissue by union of virulence factor Gal/GalNAc lectin; this molecule induces an adherence-inhibitory antibody response as well as to protect against amebic liver abscess (ALA). The present work showed the effect of the immunization with PEIII-LC3-KDEL3 recombinant protein. Read More

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(-)-Epicatechin protects from amebic liver abscess development in hamster.

Exp Parasitol 2021 May 24;224:108103. Epub 2021 Mar 24.

Laboratorio de Biomedicina Molecular 2. Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, México. Electronic address:

In this work the effect of (-)-epicatechin on the development of amebic liver abscess in hamsters was evaluated. (-)-epicatechin is a flavonoid present in plants that possesses various biological properties, including its activity against some protozoal parasites; however its antiamebic activity in a living model had not been evaluated. Syrian golden hamsters were intrahepatically inoculated with 1x10E. Read More

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Acetylcholine Upregulates Virulence Factors, Enhancing Parasite Pathogenicity in Experimental Liver Amebiasis.

Front Cell Infect Microbiol 2020 28;10:586354. Epub 2021 Jan 28.

Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico.

is an invasive enteric protozoan, whose infections are associated to high morbidity and mortality rates. However, only less than 10% of infected patients develop invasive amebiasis. The ability of to adapt to the intestinal microenvironment could be determinant in triggering pathogenic behavior. Read More

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January 2021

Host Protective Mechanisms to Intestinal Amebiasis.

Trends Parasitol 2021 02 23;37(2):165-175. Epub 2020 Oct 23.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA. Electronic address:

The protozoan parasite Entamoeba histolytica is the causative agent of amebiasis, an infection that manifests as colitis and, in some cases, liver abscess. A better understanding of host protective factors is key to developing an effective remedy. Recently, significant advances have been made in understanding the mechanisms of MUC2 production by goblet cells upon amebic infection, regulation of antimicrobial peptide production by Paneth cells, the interaction of commensal microbiota with immune stimulation, and host genetics in conferring protection from amebiasis. Read More

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February 2021

Factors Associated with High Rates of Recurrence of Amebic Liver Abscess (ALA) in North India.

Am J Trop Med Hyg 2021 Jan 11. Epub 2021 Jan 11.

Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Recurrence of amebic liver abscess (ALA), once considered unusual, is increasingly being reported, despite proper management. Realizing the endemicity of ALA in the study setup, this 2-year follow-up study was conducted to investigate the recurrent cases and study the associated factors. A total of 101 confirmed cases of ALA were followed up for a period of 2 years. Read More

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January 2021

Antibiomania: A Rare Case of Metronidazole-Induced Mania.

Cureus 2021 Jan 1;13(1):e12414. Epub 2021 Jan 1.

Internal Medicine, Sunil Khetrapal's Hospital, New Delhi, IND.

Metronidazole is a very commonly used drug for the treatment of ailments caused by bacteria and parasites. It can treat a vast array of conditions like rosacea, sexually transmitted diseases (STDs), liver abscess, bedsores, etc. Metronidazole comes with generic side-effects like nausea, vomiting, dizziness, metallic taste, and also rare side-effects like paresthesia, syncope, cerebellar symptoms, psychosis but mania is a rare side-effect. Read More

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January 2021

Secondary infection of amoeba and typhoid fever in severe malnourished pediatric patient with Type I choledocal cyst: a case report.

Oxf Med Case Reports 2020 Dec 28;2020(12):omaa111. Epub 2020 Dec 28.

Department of Child's Health, Faculty of Medicine Padjadjaran University/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.

Amebiasis is caused by the protozoan . Extraintestinal amebiasis manifestation includes liver abscess and other rare manifestations involving the lungs, heart and brain. Liver abscess is the most common extraintestinal manifestation. Read More

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December 2020

Linearolactone and Kaempferol Disrupt the Actin Cytoskeleton in : Inhibition of Amoebic Liver Abscess Development.

J Nat Prod 2020 12 24;83(12):3671-3680. Epub 2020 Nov 24.

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, México.

Linearolactone () and kaempferol () have amebicidal activity in studies. The type of cell death induced by and and their effects on the virulence of were analyzed by transmission and confocal electron microscopy, reactive oxygen species (ROS) production, and apoptosis, detected by flow cytometry with dichlorofluorescein 2',7'-diacetate and annexin-V binding, respectively, and confirmed by TUNEL. The interaction of and with actin was analyzed by docking, and the amoebicidal activity was established with the model; amebic liver abscess (ALA) development was evaluated by magnetic resonance (MR) and validated . Read More

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December 2020

Pulmonary Thromboembolism: A Rare Vascular Complication of Amebic Liver Abscess.

Cureus 2020 Oct 10;12(10):e10872. Epub 2020 Oct 10.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

Amebic liver abscess (ALA) is the most common extra-intestinal manifestation of amebiasis. Its complications include rupture into peritoneum, pleural space or anterior abdominal wall. Large abscesses can cause compression of neighboring vascular structures with thrombus formation. Read More

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October 2020

Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice.

iScience 2020 Sep 8;23(9):101544. Epub 2020 Sep 8.

Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.

, a protozoan parasite in the lumen of the human large intestine, occasionally spreads to the liver and induces amebic liver abscesses (ALAs). Upon infection with , high levels of type 2 cytokines are induced in the liver early after infection. However, the sources and functions of these initial type 2 cytokines in ALA formation remain unclear. Read More

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September 2020

Differential Pathogenic Gene Expression of in Patients with Different Clinical Forms of Amoebiasis.

Microorganisms 2020 Oct 9;8(10). Epub 2020 Oct 9.

Laboratorio de Inmunología, Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM, México City, Mexico.

The etiological agent of human amoebiasis is the protozoan parasite ; the disease is still an endemic infection in some countries and the outcome of infection in the host infection can range from asymptomatic intestinal infection to intestinal or liver invasive forms of the disease. The invasive character of this parasite is multifactorial and mainly due to the differential expression of multiple pathogenic genes. The aim of the present work was to measure the differential expression of some genes in different specimens of patients with amoebic liver abscess (ALA) and specimens of genital amoebiasis (AG) by RT-qPCR. Read More

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October 2020

Multi-Laboratory Evaluation of a Lateral Flow Rapid Test for Detection of Amebic Liver Abscess.

Am J Trop Med Hyg 2020 12 24;103(6):2233-2238. Epub 2020 Sep 24.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Independent evaluations of XEh Rapid, an IgG4-based rapid dipstick test, were performed to assess its diagnostic performance to detect amebic liver abscess (ALA) using 405 samples at seven laboratories in four countries. The test showed high diagnostic specificity (97-100%) when tested with samples from healthy individuals ( = 100) and patients with other diseases ( = 151). The diagnostic sensitivity was tested with a total of 154 samples, and the results were variable. Read More

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December 2020

Case report: multiple and atypical amoebic cerebral abscesses resistant to treatment.

BMC Infect Dis 2020 Sep 14;20(1):669. Epub 2020 Sep 14.

Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Ed. 202 Av Universidad # 940, Ciudad Universitaria, CP 20131, Aguascalientes, AGS, Mexico.

Background: The parasite Entamoeba histolytica is the causal agent of amoebiasis, a worldwide emerging disease. Amebic brain abscess is a form of invasive amebiasis that is both rare and frequently lethal. This condition always begins with the infection of the colon by E. Read More

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September 2020

A rare hepatic mass in an Italian resident.

BMC Gastroenterol 2020 Sep 11;20(1):295. Epub 2020 Sep 11.

Department of Internal Medicine (DiMI), Clinical Immunology Unit, University of Genoa and Policlinico San Martino, Viale Benedetto XV, 6 -, 16132, Genova, Italy.

Background: Amebiasis is a rare condition in developed countries but epidemiologically growing. Clinical manifestation may range from asymptomatic to invasive disease, amoebic liver abscess being the most common manifestation. We report a peculiar case of left hepatic amoebic liver abscess in a patient without a well-known source of infection and presenting with left portal vein thrombosis. Read More

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September 2020

Metastatic amebic brain abscess: A rare presentation.

Trop Parasitol 2020 Jan-Jun;10(1):47-49. Epub 2020 May 20.

Department of Medicine, AIIMS, New Delhi, India.

Amebiasis is an endemic protozoal infection in developing countries. Extra-intestinal involvement in the form of abscess is frequently seen in liver and lungs. The occurrence of amebic brain abscess is a rare and life-threatening presentation of systemic amebiasis. Read More

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Safe and pivotal approaches using contrast-enhanced ultrasound for the diagnostic workup of non-obstetric conditions during pregnancy, a single-center experience.

Arch Gynecol Obstet 2021 01 6;303(1):103-112. Epub 2020 Aug 6.

Department of Radiology, University Hospital LMU, Ludwig-Maximilians-University Munich, Grosshadern Campus, Munich, Germany.

Purpose: Conventional ultrasound is the main imaging modality in obstetrics for assessing the maternal and fetal status. Up to date, contrast-enhanced ultrasound (CEUS) has not found widespread use in gynecology and obstetrics, but recent studies demonstrate promising results. The aim of the present study is to assess safe and valuable application of CEUS during pregnancy to investigate non-obstetric conditions. Read More

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January 2021

Huge Amoebic Liver Abscess in the Left Lobe Treated by Oral Administration of Metronidazole.

Intern Med 2020 Dec 28;59(23):3023-3026. Epub 2020 Jul 28.

Department of Gastroenterology, Dokkyo Medical University School of Medicine, Japan.

A man in his 60s visited a clinic with chief complaints of a fever and general malaise. Suspecting a liver abscess in the left lobe with infiltration into the subcutaneous fat tissue under the rectus abdominis muscle based on computed tomography findings, we performed fine-needle aspiration. An amoebic liver abscess was diagnosed. Read More

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December 2020

Current Status of Amebic Liver Abscess in Korea Comparing with Pyogenic Liver Abscess.

Korean J Gastroenterol 2020 07;76(1):28-36

Division of Gastroenterology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Backgrounds/aims: With the improvement of hygiene, the incidence of amebic liver abscess is decreasing in South Korea. On the other hand, there is little data on the status of amebic liver abscess compared to pyogenic liver abscess.

Methods: Patients with an amebic liver abscess, in whom () IgG was positive, were identified retrospectively in a university hospital. Read More

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Travel history can make the difference.

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):334-336

Clinical Laboratory of Microbiology, OLVZ Aalst, Aalst, Belgium.

Entamoeba histolytica infections are rare in developed countries such as Belgium. A 53-year-old female patient presented with 10 days of fever and mild persisting pain in the right hypochondriac despite 6 days of antibiotic therapy. The anamnesis further revealed that the patient was born in Colombia and visits her native country on a regular basis. Read More

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October 2020

Gastric tuberculosis mimicking liver abscess - A case report.

Indian J Tuberc 2020 Apr 1;67(2):274-276. Epub 2020 Feb 1.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Raibareli Road, Lucknow 226014, India.

Tuberculosis of the stomach is quite rare, both as a primary or secondary infection. It has varied presentation ranging from non-specific abdominal pain and constitutional symptoms to hematemesis, gastric outlet obstruction and pyrexia of unknown origin. Here, we report a rare, interesting case of locally advanced gastric tuberculosis, which morphologically mimicked liver abscess initially in a young, immunocompetent patient presenting with fever and abdominal pain. Read More

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Successful surgical drainage with intraoperative ultrasonography for amebic liver abscess refractory to metronidazole and percutaneous drainage: a case report.

BMC Surg 2020 May 24;20(1):112. Epub 2020 May 24.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: Metronidazole (MNZ) has been clearly established as a medication for amebic liver abscess. In uncomplicated cases, surgical drainage should be avoided. We report a case of amebic liver abscess refractory to MNZ that was successfully treated using preoperative computed tomography (CT) and percutaneous and surgical drainage with intraoperative ultrasonography (IOUS). Read More

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Successful Treatment of Bronchobiliary Fistula After Living Donor Liver Transplantation: A Case Report.

Transplant Proc 2020 Nov 17;52(9):2778-2780. Epub 2020 May 17.

Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (R.O.C.); Department of Medical Imaging, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan (R.O.C.). Electronic address:

A bronchobiliary fistula (BBF), which is defined by abnormal communication between the biliary system and the bronchial tree, is usually regarded as a consequence of local infection, such as hydatid or amebic disease of the liver, hepatic abscess, trauma, neoplasm, and other causes of biliary obstruction. We present a 40-year-old female patient who received a living donor liver transplantation for autoimmune hepatitis and who suffered from biliary stricture at the anastomosis, bile leakage in the right subphrenic region, and development of a BBF 1 year later. Magnetic resonance cholangiography (MRC) and fistulography showed a fistula between the subphrenic biloma and right lower bronchus. Read More

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November 2020

Pyogenic and Amebic Infections of the Liver.

Gastroenterol Clin North Am 2020 06;49(2):361-377

Division of Gastroenterology, Hepatology Program, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

Pyogenic liver abscesses are classified by the bacteria that have caused the abscess because this guides treatment and can point to the underlying cause. The most common cause is biliary disease. The diagnosis is made by imaging. Read More

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Pediatric Liver Abscess: Trends in the Incidence, Etiology, and Outcomes Based on 20-Years of Experience at a Tertiary Center.

Front Pediatr 2020 24;8:111. Epub 2020 Mar 24.

Division of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.

Liver abscess is an important but relatively rare disease in children. This study investigated the clinical characteristics of eligible patients at a referral tertiary center over the past two decades. A 20-year retrospective study (January 2000-December 2019) enrolled 38 children diagnosed with liver abscess. Read More

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EhRab21 associates with the Golgi apparatus in Entamoeba histolytica.

Parasitol Res 2020 May 26;119(5):1629-1640. Epub 2020 Mar 26.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del I.P.N., Avenida Instituto Politécnico Nacional No. 2508, Col. San Pedro Zacatenco, Delegación Gustavo A. Madero, CP 07360, Mexico City, Mexico.

Rab proteins constitute the largest group of small GTPases and act as molecular switches in a wide variety of cellular processes, including proliferation, cytoskeleton assembly, and membrane trafficking in all eukaryotic cells. Rab21 has been reported in several eukaryotic cells, and our results suggest that in Entamoeba histolytica, Rab21 is involved in the vesicular traffic associated with the Golgi apparatus, where its function appears to be important to maintain the structure of this organelle. In addition, proteins such as Rab1A and Sec24, identified in this work associated with EhRab21, participate in the traffic of COPII vesicles from the endoplasmic reticulum to the Golgi apparatus and are necessary to maintain the latter's structure in human cells. Read More

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Neutrophil extracellular traps and MPO in models of susceptibility and resistance against Entamoeba histolytica.

Parasite Immunol 2020 06 7;42(6):e12714. Epub 2020 Apr 7.

Sección de Estudios de Posgrado e investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, CDMX, México.

The main effector mechanisms of neutrophils are the release of neutrophil extracellular traps (NETs) and myeloperoxidase (MPO). In this work, we evaluated the role of NETs and the activity of MPO in the interactions of rodent neutrophils with amoebae and in amoebic liver abscess (ALA)-resistant and ALA-susceptible models. We showed with in vitro assays that mice produced greater amounts of NETs and MPO than did hamsters, and the elastase activity was high in both models. Read More

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Hepatobiliary and Pancreatic: EUS-guided drainage of a ruptured amoebic liver abscess in a child.

J Gastroenterol Hepatol 2020 Jun 6;35(6):921. Epub 2020 Mar 6.

Division Of Paediatric Gastroenterology, Post Graduate Institute Of Medical Education and Research, Chandigarh, India.

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Incidence Trends, Comorbidities, and Outcomes of Pyogenic Liver Abscess Among Children: A Nationwide Population-based Analysis.

J Pediatr Gastroenterol Nutr 2020 07;71(1):106-111

Department of Pediatric Gastroenterology, Cleveland Clinic Children's hospital, Cleveland, OH.

Objectives: Population-based analysis of incidence, comorbid conditions, microbiological characteristics, and outcomes of pyogenic liver abscess (PLA) in children.

Methodology: Retrospective analysis of National Inpatient Sample (NIS) and Kids Inpatient database (KID) database from 2003 to 2014 and included patients between 1 and 20 years of age. Using ICD-9 codes, we identified all hospitalizations with PLA and compared them with 1 : 10 age- and gender-matched controls. Read More

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