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Rev Soc Bras Med Trop 2022 29;55:e00502022. Epub 2022 Apr 29.

Uniclinic Diagnóstico por Imagem, Fortaleza, CE, Brasil.

BMC Med 2022 May 2;20(1):144. Epub 2022 May 2.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ubiquitous priority (i.e. Read More

BMC Infect Dis 2022 Apr 11;22(1):364. Epub 2022 Apr 11.

Department of Critical care Medicine, Affiliated Hospital of Zunyi Medical University, Dalian Road 149, Zunyi City, 563003, Guizhou, China.

Background: Amoebiasis is caused by the protozoan Entamoeba histolytica, which is a rare infectious disease in developed countries. If the trophozoites enter the blood, it can spread through the body, such as brain, and lungs. Cases of simultaneous infection of multiple organs are extremely rare. Read More

Front Cell Infect Microbiol 2022 22;12:855822. Epub 2022 Mar 22.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México (CDMX), México.

is a protozoan-pathogen-causing amoebic liver abscess (ALA). After amoeba establishment in the liver, it causes abundant infiltrate of neutrophils. Liver tissue damage by neutrophils results in part from anti-amoebic oxidative intermediates, including reactive oxygen species (ROS), reactive nitrogen species (RNS), and hypochlorous acid (HOCl), derived from the myeloperoxidase (MPO) enzyme. Read More

Rev Soc Bras Med Trop 2022;55:e0665. Epub 2022 Feb 25.

Hospital Selayang, Medical Department, Selangor, Malaysia.

Travel Med Infect Dis 2022 Mar-Apr;46:102274. Epub 2022 Feb 9.

Department of Parasitology and Medical Entomology, Muhimbili University of Health and Applied Science MUHAS, P.O. Box 65001, Dar es Salaam, Tanzania. Electronic address:

Introduction: Entamoeba histolytica is a protozoan parasite with worldwide distribution, higher in countries with poor sanitation due to its oral-faecal way of transmission. It is the causative agent of amoebic colitis and extraintestinal amoebiasis, and accounts for 40 000-100 000 deaths yearly. Amoebiasis can be complicated by liver abscess in 9% of cases. Read More

IDCases 2022 1;27:e01441. Epub 2022 Feb 1.

Division of Infectious Diseases, Ann & Robert H Lurie Children's Hospital, USA.

Amebic liver abscess (ALA) is a common condition in the developing world but is rare in the United States without a clear exposure risk. It is even less common to develop in an infant. The diagnosis of ALA can be logistically difficult and often requires invasive procedures and testing with slow turnaround times. Read More

BMC Gastroenterol 2022 Feb 7;22(1):52. Epub 2022 Feb 7.

Gastroenterology Division, Department of Medicine, Icahn School of Medicine at Elmhurst Hospital, Elmhurst, NY, 11373, USA.

Background: Juxta-papillary duodenal diverticulum (JPDD) has been associated with obstructive jaundice and ascending cholangitis. Potential mechanisms include periampullary colonization of pathogenic bacteria and mechanical obstruction. However, the relation of JPDD with pyogenic liver abscess (PLA) has not been reported. Read More

Surg J (N Y) 2021 Oct 23;7(4):e351-e356. Epub 2021 Dec 23.

Department of General Surgery, Seth G.S. Medical College & KEM Hospital, Mumbai, India.

 Amebic liver abscess (ALA) contributes significantly to morbidity and mortality in patients of the developing world. Even though medical management is the primary modality of treatment, 15% of the cases are refractory and require intervention for drainage. Pigtail catheterization is inefficient and results in a long duration of hospital stay. Read More

Abdom Radiol (NY) 2022 03 29;47(3):1157-1166. Epub 2021 Dec 29.

Department of Interventional Radiology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India.

Background: Amebic liver abscess is the most common type of liver abscess on a worldwide basis, with caudate lobe being a relatively uncommon location for its occurrence. Abscess in caudate lobe of liver is often considered a challenging location for image-guided percutaneous drainage due to its difficult-to-access location along with close relationship with major vessels at porta hepatis.

Purpose: This study aims to demonstrate safety and efficacy of percutaneous drainage for caudate lobe amebic abscess. Read More

Hong Kong Med J 2021 12;27(6):450-451

Private Practice, 12/F, Emperor Commercial Centre, Central, Hong Kong.

Travel Med Infect Dis 2022 Jan-Feb;45:102241. Epub 2021 Dec 14.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 833, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Am J Case Rep 2021 Dec 11;22:e934188. Epub 2021 Dec 11.

Faculty of Medicine, Alfonso X El Sabio University, Madrid, Spain.

BACKGROUND Amebiasis is a parasitic infection caused by the protozoan Entamoeba histolytica. Amebic brain abscesses are a rare form of invasive amebiasis frequently lethal due to the difficulty of its diagnosis and inadequate treatment. Cerebral amebiasis poses a therapeutic challenge as evidenced by the scarcity of papers reporting complete recovering after treatment. Read More

Pediatr Clin North Am 2022 02;69(1):79-97

West Virginia University School of Medicine, One Medical Center Drive, HSC 9214, Morgantown, WV 26506, USA.

Although rare in the developed world, amebiasis continues to be a leading cause of diarrhea and illness in developing nations with crowding, poor sanitation, and lack of clean water supply. Recent immigrants or travelers returning from endemic regions after a prolonged stay are at high risk of developing amebiasis. A high index of suspicion for amebiasis should be maintained for other high-risk groups like men having sex with men, people with AIDS/HIV, immunocompromised hosts, residents of mental health facility or group homes. Read More

BMC Infect Dis 2021 Nov 4;21(1):1134. Epub 2021 Nov 4.

Infectious Diseases Department, University Hospital of Caracas, Caracas, Venezuela.

Background: Amoebiasis is a parasitic disease caused by Entamoeba histolytica, which affects people living in low- and middle-income countries and has intestinal and extraintestinal manifestations. To date, knowledge on coronavirus disease 2019 (COVID-19) coinfection with enteric parasites is limited, and E. histolytica coinfection has not been previously described. Read More

J Hepatol 2022 01 29;76(1):160-173. Epub 2021 Sep 29.

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Electronic address:

Background & Aims: An invasive form of intestinal Entamoeba (E.) histolytica infection, which causes amoebic liver abscess, is more common in men than in women. Immunopathological mechanisms are responsible for the more severe outcome in males. Read More

Acta Trop 2021 Dec 24;224:106114. Epub 2021 Aug 24.

Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Brazil.

Amoebiasis is a protozoan disease caused by Entamoeba histolytica, and presents a geographic distribution of worldwide amplitude, high incidence, sometimes accompanied by severe clinical manifestations such as amoebic colitis and Amoebic Liver Abscess (ALA), remaining as a public health problem in developing countries. Entamoeba dispar is another species of amoeba that infects approximately 12% of the world's population, and it has previously been classified as noninvasive. However, E. Read More

Cureus 2021 Jul 15;13(7):e16409. Epub 2021 Jul 15.

Internal Medicine, Medical City Weatherford, Weatherford, USA.

Pyogenic liver abscesses (PLA) are an uncommon, but potentially life-threatening infection. Although the link between amebic liver abscesses and obstructive jaundice is well documented, there are few cases of PLA leading to this complication. We present a case of multiple massive PLA and obstructive jaundice on initial presentation. Read More

Mucosal Immunol 2022 01 16;15(1):165-175. Epub 2021 Aug 16.

Department of Medicine: Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USA.

Entamoeba histolytica is a pathogenic protozoan parasite that causes intestinal colitis, diarrhea, and in some cases, liver abscess. Through transcriptomics analysis, we observed that E. histolytica infection was associated with increased expression of IL-33 mRNA in both the human and murine colon. Read More

Acta Gastroenterol Belg 2021 Apr-Jun;84(2):362-364

Department of Gastroenterology and Hepatology, Maria Middelares Hospital, Buitenring Sint-Denijs 30, 9000 Gent, Belgium.

In this case report we present a family cluster of amoebiasis in a nonendemic region. A 46-year-old women, diagnosed with Crohn's disease for which she received no maintenance therapy, was evaluated for the suspicion of a flare. At colonoscopy however, atypical findings for Crohn's disease were seen. Read More

J Hepatol 2021 08 11;75(2):481-482. Epub 2021 Jun 11.

Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Electronic address:

Trop Doct 2021 Oct 9;51(4):488-491. Epub 2021 Jun 9.

Professor, Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.

Definitive diagnosis of amoebic liver abscess is challenging owing to the unavailability of sensitive commercial point-of-care molecular tests. The primary aim of our prospective diagnostic study was to compare available laboratory methods for the diagnosis of in clinical samples with loop-mediated isothermal amplification. We compared deoxyribonucleic acid (DNA) analysis methods, namely, loop-mediated isothermal amplification and reverse transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay (ELISA) using pus, stool and blood samples from 200 patients with clinical and radiological diagnosis of amoebic liver abscess. Read More

J Travel Med 2021 08;28(6)

National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.

Rev Clin Esp (Barc) 2021 May 28;221(5):307-308. Epub 2021 Feb 28.

Servicio de Medicina Interna, Hospital 12 de Octubre, Madrid, Spain. Electronic address:

Indian J Gastroenterol 2021 Jun 15;40(3):272-280. Epub 2021 May 15.

Department of Gastroenterology, SMS Medical College and Hospital, Jaipur 302 004, India.

Background: Amebic liver abscess is treated successfully with metronidazole or another nitroimidazole drug followed by a luminal amebicide. Metronidazole has long been preferred, but has been associated with several adverse effects including intolerance in certain clinical situations. Mechanisms of metronidazole resistance and mutagenic potential have been described. Read More

Am J Med 2021 10 1;134(10):e507-e509. Epub 2021 May 1.

Department of Medicine, Eisenhower Health, Rancho Mirage, Calif; Department of Medicine, University of California, Riverside.

Parasitol Int 2021 Aug 29;83:102370. Epub 2021 Apr 29.

Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata 700010, West Bengal, India. Electronic address:

Amoebiasis caused by protozoan parasite Entamoeba histolytica has diverse infection outcomes. The relationship between parasite genotypes and outcome of amoebic infection is still a paradox and needs to be explored. Genome information of infecting strains from endemic areas throughout the world is essential to explore this relation. Read More

Abdom Radiol (NY) 2021 09 24;46(9):4148-4158. Epub 2021 Apr 24.

Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, India.

Purpose: To identify different morphological types of amebic liver abscess (ALA) based on CT findings and to assess whether they have different clinical features.

Method: CT images of 112 symptomatic patients with ALA were analyzed to identify the imaging features distinctive of each morphological type. The following CT findings were investigated: the presence of abscess wall, rim enhancement, edge characteristic, septa, intermediate density zone, and peripheral hypodensity. Read More

Pediatr Infect Dis J 2021 05;40(5):e179-e184

Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Liver abscess (LA), a common problem in children in the tropics, is believed to be mostly pyogenic (PLA), sometimes amebic (ALA). We aimed to analyze the clinical profile, etiology, risk factors for complications, management and outcomes of LA in children.

Methods: The details of 81 children with LA managed in a tertiary set up over a period of 3 years were analyzed. Read More

J Immunol Res 2021 20;2021:6697900. Epub 2021 Mar 20.

Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, C. P. 20131., Aguascalientes, Ags., Mexico.

is an intestinal parasite that causes dysentery and amebic liver abscess. has the capability to invade host tissue by union of virulence factor Gal/GalNAc lectin; this molecule induces an adherence-inhibitory antibody response as well as to protect against amebic liver abscess (ALA). The present work showed the effect of the immunization with PEIII-LC3-KDEL3 recombinant protein. Read More