13,874 results match your criteria Amebiasis


Fournier's Necrosis Associated With Extraintestinal Amebiasis: A Rare Presentation of a Common Infection.

J Obstet Gynaecol Can 2019 May;41(5):577

Fundación Valle del Lili, Cali, Colombia; Universidad Icesi, Cali, Colombia.

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http://dx.doi.org/10.1016/j.jogc.2018.01.030DOI Listing

Mechanisms of natural resistance of Balb/c mice to experimental liver amoebiasis.

Biosci Rep 2019 Apr 12. Epub 2019 Apr 12.

Unidad de Investigación en Medicina Experimental, Universidad Nacional Autónoma de México, Avenida Universidad 3000, México, 04510, Mexico

is the parasite responsible for human amoebiasis. The analysis of the natural resistance mechanisms of some rodents to amebic liver abscess (ALA) may reveal alternative pathogenicity mechanisms to those previously discovered in the experimental model of ALA in hamsters. In this work the natural resistance of BALB/c mice to ALA was explored by performing: 1) chemotaxis analysis with a specifically designed chamber; 2) amebic survival in fresh and decomplemented serum; 3) histological temporal course analysis of ALA development in mice with different treatments (hypocomplementemic, hyperimmune and treated with iNOS and NADPH oxidase inhibitors) and 4) mouse liver amebic infection by both implantation of ALA from hamsters and inoculation of parasites into the peritoneal cavity. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182333
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http://dx.doi.org/10.1042/BSR20182333DOI Listing
April 2019
2 Reads

Biliary Peritonitis due to a Ruptured Amebic Liver Abscess Mimicking a Periampullary Tumor and Liver Metastases with the Elevation of CA 19-9 and CA 125: A Case Report.

GE Port J Gastroenterol 2019 Mar 12;26(2):121-124. Epub 2018 Jun 12.

bDepartment of Surgery, Hospital Nacional Dos de Mayo, Lima, Peru.

Introduction: An amebic liver abscess is the most common presentation of extraintestinal amebiasis. This condition is the result of a parasite infection caused by .

Materials And Methods: We report a case of a 53-year-old male who presented with abdominal pain in the right upper quadrant, jaundice, and a 10-kg weight loss within a 1-month span. Read More

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http://dx.doi.org/10.1159/000489721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454388PMC
March 2019
1 Read

Successful Diagnosis of a Longstanding Giant Amoebic Liver Abscess Using Contrast-Enhanced Ultrasonography (CEUS): A Case Report in a Western Country.

Am J Case Rep 2019 Apr 10;20:493-498. Epub 2019 Apr 10.

Department of Radiological Sciences, Oncology and Anatomo-Pathological Science, Sapienza University of Rome, Rome, Italy.

BACKGROUND E. histolytica liver abscess results from extra-intestinal diffusion of amebiasis, which is responsible for up 100 000 deaths per annum, placing it second only to malaria in mortality. Currently, the criterion standard for the diagnosis of liver abscesses is ultrasound, but CEUS (contrast-enhanced ultrasound) is emerging as a more accurate method for liver study, and it could be more accurate than ultrasound and non-invasive compared to CT. Read More

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http://dx.doi.org/10.12659/AJCR.914378DOI Listing
April 2019
1 Read

Molecular identification of Entamoeba histolytica from stool samples of Ilam, Iran.

Comp Immunol Microbiol Infect Dis 2019 Apr 15;63:145-147. Epub 2019 Jan 15.

Department of Medical Parasitology, Paramedical Faculty, Ilam University of Medical Sciences, Ilam, Iran. Electronic address:

Introduction: Amoebiasis is a multifactorial, life-threatening public health issue and the third parasitic disease cause of mortality in worldwide, particularly in low- and mid-income countries. The aim of this study was to attempt to explore genetic encoding differences of CP8 (conserved gene) of Entamoeba histolytica/Entamoeba dispar in its various infectious properties isolated from Ilam located at a southwest part of Iran.

Materials And Methods: A total of 2023 stool samples were collected between 2016 and 2018 from the hospital in Ilam, of which only 30 isolates were identified as E. Read More

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http://dx.doi.org/10.1016/j.cimid.2019.01.003DOI Listing
April 2019
1 Read

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica.

PLoS One 2019 3;14(4):e0214880. Epub 2019 Apr 3.

Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P., India.

Background: Amebiasis, caused by Entamoeba histolytica (E. histolytica), is a significant cause of morbidity and mortality in developing countries. Mortality due to amebiasis is mostly by extra intestinal infections, amebic liver abscess being the most common one. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447230PMC
April 2019
3 Reads

Structural and functional characterisation of phosphoserine phosphatase, that plays critical role in the oxidative stress response in the parasite Entamoeba histolytica.

J Struct Biol 2019 Mar 29. Epub 2019 Mar 29.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Amoebiasis is a common parasitic infection in the developing world and is caused by the protist Entameoba histolytica. The proliferation of E. histolytica and its ability to invade epithelial tissues have been shown in several studies to be greatly decreased during oxidative stress. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10478477193006
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http://dx.doi.org/10.1016/j.jsb.2019.03.012DOI Listing
March 2019
5 Reads

Pathogenic Entamoeba histolytica, but not Entamoeba dispar, induce neutrophil extracellular trap (NET) formation.

J Leukoc Biol 2019 Mar 26. Epub 2019 Mar 26.

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Amoebiasis is an infection of global importance, caused by the eukaryotic parasite Entamoeba histolytica. Pathogenic E. histolytica is associated worldwide with over a million cases of amoebic dysentery, colitis, and amoebic liver abscess. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/JLB.MA0818-3
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http://dx.doi.org/10.1002/JLB.MA0818-309RRRDOI Listing
March 2019
4 Reads

Amebiasis, a rare cause of acute appendicitis.

J Surg Case Rep 2019 Mar 13;2019(3):rjz076. Epub 2019 Mar 13.

PGY3 Resident General Surgery, P.U.C.E, Quito, Ecuador.

Acute appendicitis is one of the most common abdominal emergencies, even though most cases of appendicitis will be due to obstruction of the appendiceal lumen, in rare occasions and mostly due to poor sanitary conditions a parasitic infection may cause appendicitis. is a common parasite and has a broad clinical spectrum from an asymptomatic disease to a life-threatening condition. In rare occasions, trophozoites can invade the appendiceal wall causing appendicitis. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz07
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http://dx.doi.org/10.1093/jscr/rjz076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415623PMC
March 2019
5 Reads

Host-antibody inductivity of virulent Entamoeba histolytica and non-virulent Entamoeba moshkovskii in a mouse model.

Parasit Vectors 2019 Mar 13;12(1):101. Epub 2019 Mar 13.

Department of Protozoology, Faculty of Tropical Medicine, Mahidol University, Ratchawithi, Bangkok, 10400, Thailand.

Background: Despite similarities in morphology, gene and protein profiles, Entamoeba histolytica and E. moshkovskii show profound differences in pathogenicity. Entamoeba histolytica infection might result in amoebic dysentery and liver abscess, while E. Read More

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http://dx.doi.org/10.1186/s13071-019-3363-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416977PMC
March 2019
1 Read

Phagocytosis of Gut Bacteria by .

Front Cell Infect Microbiol 2019 26;9:34. Epub 2019 Feb 26.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

The protist parasite causes amoebiasis, a major public health problem in developing countries. Only a small fraction of patients infected with the parasite display invasive disease involving colon or extra intestinal tissues such as liver. exists as two distinct forms, cysts, the infective form, and trophozoites, that are responsible for disease pathology. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00034
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http://dx.doi.org/10.3389/fcimb.2019.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399400PMC
February 2019
15 Reads
2.620 Impact Factor

Amoebic Cardiac Tamponade.

QJM 2019 Mar 8. Epub 2019 Mar 8.

Post Graduate Institute of Medical Education and Research, internal medicine.

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http://dx.doi.org/10.1093/qjmed/hcz062DOI Listing
March 2019
2 Reads

PtdIns(4,5)P is generated by a novel phosphatidylinositol 4-phosphate 5-kinase in the protist parasite Entamoeba histolytica.

FEBS J 2019 Mar 7. Epub 2019 Mar 7.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Entamoeba histolytica is an intestinal protist parasite that causes amoebiasis, a major source of morbidity and mortality in developing countries. Phosphoinositides are involved in signalling systems that have a role in invasion and pathogenesis of this parasite. Phosphatidylinositol 4-phosphate 5-kinase (PIP5K) catalyses the generation of phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P ), a key species of phosphoinositide that regulates various cellular processes. Read More

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http://dx.doi.org/10.1111/febs.14804DOI Listing
March 2019
4.001 Impact Factor

Evolution of Base Excision Repair in Entamoeba histolytica is shaped by gene loss, gene duplication, and lateral gene transfer.

DNA Repair (Amst) 2019 04 22;76:76-88. Epub 2019 Feb 22.

Laboratorio Nacional de Genómica para la Biodiversidad, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Km. 9.6 Libramiento Norte Carretera Irapuato-León 36821, Irapuato, Gto, CP 36500, Mexico. Electronic address:

During its life cycle, the protist parasite Entamoeba histolytica encounters reactive oxygen and nitrogen species that alter its genome. Base excision repair (BER) is one of the most important pathways for the repair of DNA base lesions. Analysis of the E. Read More

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http://dx.doi.org/10.1016/j.dnarep.2019.02.009DOI Listing
April 2019
2 Reads

EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica.

PLoS Pathog 2019 02 19;15(2):e1007573. Epub 2019 Feb 19.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Motility and phagocytosis are key processes that are involved in invasive amoebiasis disease caused by intestinal parasite Entamoeba histolytica. Previous studies have reported unconventional myosins to play significant role in membrane based motility as well as endocytic processes. EhMyosin IB is the only unconventional myosin present in E. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396940PMC
February 2019

Transcriptomic and microbiota response on Litopenaeus vannamei intestine subjected to acute sulfide exposure.

Fish Shellfish Immunol 2019 May 14;88:335-343. Epub 2019 Feb 14.

Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, PR China; Key Laboratory of Fishery Ecology and Environment, Guangdong Province, PR China. Electronic address:

Harmful effects of water pollutants are myriad. Sulfide from water bodies affects the aquatic animals. Intestine barrier function serves as the front-line of animals defense. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.021DOI Listing

Vorinostat, a possible alternative to Metronidazole for the treatment of amebiasis caused by Entamoeba histolytica.

J Biomol Struct Dyn 2019 Feb 12:1-9. Epub 2019 Feb 12.

d Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca-Actopan , San Agustín Tlaxiaca , Hidalgo , México .

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http://dx.doi.org/10.1080/07391102.2019.1578693DOI Listing
February 2019

Molecular characterization of Blastocystis in cattle in Turkey.

Parasitol Res 2019 Mar 9;118(3):1055-1059. Epub 2019 Feb 9.

Department of Parasitology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey.

Blastocystis genus exist in a wide variety of hosts, including humans, birds, insects, annelids, amphibians, fish, and mammals. PCR-based molecular diagnostic methods have been successfully used to detect Blastocystis spp. in feces, and small subunit ribosomal ribonucleic acid (SSU rRNA) gene-based subtyping is the preferred method for diagnosis. Read More

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http://dx.doi.org/10.1007/s00436-019-06243-8DOI Listing
March 2019
3 Reads

Comparative examination on selected amphizoic amoebae in terms of their in vitro temperature tolerance – a possible indirect marker of potential pathogenicity of Acanthamoeba strains

Ann Parasitol 2018;64(4):317-322

Department of Medical Biology, Medical University of Warsaw, ul. Nowogrodzka 73, 02-018 Warsaw, Poland

Acanthamoeba species are ubiquitous in natural and man-made environments worldwide; some strains are able to colonize human eyes as facultative parasites. It has been shown that environmental and clinical isolates/species of Acanthamoeba vary in their pathogenicity. In this study we examine and compare the in vitro effects of the changing temperature on the population dynamics of subsequent amoebic strains. Read More

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Amoebas from the genus Acanthamoeba and their pathogenic properties

Ann Parasitol 2018;64(4):299-308

Department of Biology and Medical Parasitology, Faculty of Medicine, Biotechnology and Laboratory Medicine, Pomeranian Medical University in Szczecin, ul. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland

Amoebas from the genus Acanthamoeba are cosmopolitan organisms, which can exist as free-living organisms and as parasites within host tissue. Acanthamoeba infection present a serious risk to human health and are characterized by high mortality, especially in immunocompromised individuals. These protozoa are the etiological factors of granulomatous amoebic encephalitis (GAE) and Acanthamoeba keratitis (AK). Read More

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April 2019
14 Reads

Acanthamoeba spp. from water and soil sources in Iran: a systematic review and meta-analysis

Ann Parasitol 2018;64(4):285–297

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Farah Abad Road, Sari, Iran

Acanthamoeba, an opportunistic protozoan parasite, is distributed in the environment globally, causes serious human infections, including a fatal encephalitis and keratitis. The purpose of this study was to evaluate the prevalence and genotyping of Acanthamoeba spp. from different water and soil sources in Iran. Read More

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April 2019
2 Reads

Amebic colonic stricture: An unusual presentation.

Trop Parasitol 2018 Jul-Dec;8(2):98-100. Epub 2018 Dec 27.

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

infection can lead to colitis, peri-colic abscess, ameboma, perforation and rarely colonic stricture. Amebic colitis is usually managed with medical management and rarely needs surgical management. We hereby report a case of colonic amebiasis, presenting as a stricture in transverse colon, mimicking malignancy, and managed successfully. Read More

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http://dx.doi.org/10.4103/tp.TP_40_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329265PMC
December 2018
2 Reads

Cyclooxygenase-Like Protein Regulates Cysteine Protease Expression and Virulence.

Front Cell Infect Microbiol 2018 9;8:447. Epub 2019 Jan 9.

Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.

The intestinal protozoan parasite () causes amebiasis associated with severe diarrhea and/or liver abscess. pathogenesis is multifactorial requiring both parasite virulent molecules and host-induced innate immune responses. -induced host pro-inflammatory responses plays a critical role in disease pathogenesis by causing damage to tissues allowing parasites access to systemic sites. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00447
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http://dx.doi.org/10.3389/fcimb.2018.00447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333869PMC
January 2019
12 Reads

Genotypic diversity of Acanthamoeba strains isolated from Chilean patients with Acanthamoeba keratitis.

Parasit Vectors 2019 Jan 25;12(1):58. Epub 2019 Jan 25.

Subdepartamento de Genética Molecular, Instituto de Salud Pública de Chile, Av. Marathon 1000, Ñuñoa, CP 7780050, Santiago, Chile.

Background: Acanthamoeba spp. are the causative agents of a severe keratitis occurring mainly in contact lens wearers. The genus comprises more than 24 species that are currently divided into 20 different genotypes (T1-T20) according to sequence variations in the 18S rRNA gene. Read More

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http://dx.doi.org/10.1186/s13071-019-3302-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346584PMC
January 2019
3 Reads

Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells.

Front Cell Infect Microbiol 2018 8;8:437. Epub 2019 Jan 8.

Programa en Biomedicina Molecular y Red de Biotecnología, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City, Mexico.

MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression. Recent evidences suggested that host cells miRNAs are involved in the progression of infectious diseases, but its role in amoebiasis remains largely unknown. Here, we reported an unexplored role for miRNAs of human epithelial colon cells during the apoptosis induced by . Read More

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http://dx.doi.org/10.3389/fcimb.2018.00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333105PMC
January 2019
5 Reads
2.620 Impact Factor

Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba.

Genome Biol Evol 2019 03;11(3):688-705

Earlham Institute, Norwich Research Park, Norwich, United Kingdom.

Amoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Although the primary etiological agent of amoebiasis is the obligate human parasite Entamoeba histolytica, other members of the genus Entamoeba can infect humans and may be pathogenic. Here, we present the first annotated reference genome for Entamoeba moshkovskii, a species that has been associated with human infections, and compare the genomes of E. Read More

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http://dx.doi.org/10.1093/gbe/evz009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414313PMC
March 2019
1 Read

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
4 Reads

Evaluation of the sensitivity to chlorhexidine, voriconazole and itraconazole of T4 genotype Acanthamoeba isolated from Mexico.

Exp Parasitol 2019 Feb 12;197:29-35. Epub 2019 Jan 12.

Faculty of Superior Studies Iztacala, UNAM. Tlalnepantla, State of Mexico, Mexico. Electronic address:

Free-living amoebae of the genus Acanthamoeba are the etiological agents of cutaneous lesions, granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK), which are chronic infections with poor prognosis if not diagnosed promptly. Currently, there is no optimal therapeutic scheme to eradicate the pathologies these protozoa cause. In this study we report the morphological and molecular identification of three species of the genus Acanthamoeba, belonging to T4 group; A. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.01.006DOI Listing
February 2019
2 Reads
1.859 Impact Factor

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development.

Can J Gastroenterol Hepatol 2018 2;2018:4601420. Epub 2018 Dec 2.

Hospital Corporation of America, East Florida Division, Fort Lauderdale, FL, USA.

is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with remain asymptomatic, some present with amoebic colitis and disseminated disease. Read More

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http://dx.doi.org/10.1155/2018/4601420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304615PMC
December 2018
1 Read

Antiamoebic drugs for treating amoebic colitis.

Cochrane Database Syst Rev 2019 01 9;1:CD006085. Epub 2019 Jan 9.

Department of Pediatrics, University of the Philippines Manila College of Medicine-Philippine General Hospital, Taft Avenue, Manila, National Capital Region, Philippines, 1000.

Background: Infection with the protozoan Entamoeba histolytica is common in low- and middle-income countries, and up to 100,000 people with severe disease die every year. Adequate therapy for amoebic colitis is necessary to reduce illness, prevent development of complicated disease and extraintestinal spread, and decrease transmission.

Objectives: To evaluate antiamoebic drugs for treating amoebic colitis. Read More

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http://dx.doi.org/10.1002/14651858.CD006085.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326239PMC
January 2019
4 Reads

Biological information analysis of differentially expressed genes in oral squamous cell carcinoma tissues in GEO database.

J BUON 2018 Nov-Dec;23(6):1662-1670

College of Computer Science, Sichuan University, Chengdu, Sichuan 610065, P.R.China.

Purpose: This study aimed to detect the differentially expressed genes between oral squamous cell carcinoma (OSCC) tissues and adjacent normal tissues, and perform pathway analysis and protein-protein interaction (PPI) analysis on differentially expressed genes (DEGs).

Methods: Gene Expression Omnibus (GEO) database related to human tumors was selected from the National Center for Biotechnology Information (NCBI), and GSE31056 and GSE3524, two microarrays containing OSCC gene expression data, were extracted from it. Analysis of differentially expressed genes in the two microarrays was performed using "R" software, and the volcanic map was drawn. Read More

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January 2019
2 Reads

The Prevalance of Blastocystosis among Patients with Gastrointestinal and Dermatologic Complaints and Effects of Blastocystis spp. Density on Symptomatology.

Turkiye Parazitol Derg 2018 Dec;42(4):254-257

Ege Üniversitesi Tıp Fakültesi, Tıbbi Parazitoloji Ana Bilim Dalı, İzmir, Türkiye.

Objective: Blastocystosis has been linked with non-specific symptoms, such as diarrhea, abdominal pain, and distention. In this study, we evaluated the relationship between Blastocystis spp. with urticaria and intestinal symptoms. Read More

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http://dx.doi.org/10.5152/tpd.2018.5702DOI Listing
December 2018
3 Reads

Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression.

Cancer Cell Int 2018 22;18:214. Epub 2018 Dec 22.

1Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310022 China.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism underlying PDAC progression remains far from clear. Read More

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http://dx.doi.org/10.1186/s12935-018-0718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303882PMC
December 2018
3 Reads
1.989 Impact Factor

Entamoeba gingivalis - prevalence and correlation with dental caries in children from rural and urban regions of Lublin Province, Eastern Poland.

Ann Agric Environ Med 2018 Dec 18;25(4):656-658. Epub 2017 Dec 18.

Chair and Department of Jaw Orthopaedics, Medical University of Lublin, Poland.

Introduction: Entamoeba gingivalis, as the name implies. typically lives around the gumline of the teeth in the tartar and gingival pockets of the oral cavity. Pathogenicity of protozoa in the oral cavity is not completely understood. Read More

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http://www.journalssystem.com/aaem/Entamoeba-gingivalis-the-
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http://dx.doi.org/10.26444/aaem/80403DOI Listing
December 2018
17 Reads

Effect of povidone iodine, chlorhexidine digluconate and toyocamycin on amphizoic amoebic strains, infectious agents of Acanthamoeba keratitis - a growing threat to human health worldwide.

Ann Agric Environ Med 2018 Dec 3;25(4):725-731. Epub 2018 Dec 3.

Department of Medical Biology, Medical University, Warsaw, Poland.

Introduction: Free-living amoebae, ubiquitous in outer environments, in predisposing circumstances may exist as parasites, infectious agents of Acanthamoeba keratitis. In recent decades, the vision-threatening corneal infection is a growing human health threat worldwide, including Poland. The applied therapy is often ineffective due to diagnostic mistakes, various pathogenicity of Acanthamoeba strains and high resistance of cysts to drugs; many agents with possible anti-amoebic activity are still being tested. Read More

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http://dx.doi.org/10.26444/aaem/99683DOI Listing
December 2018
44 Reads

Amebic Liver Abscess.

N Engl J Med 2018 Dec;379(23):2255

Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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http://www.nejm.org/doi/10.1056/NEJMicm1800360
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http://dx.doi.org/10.1056/NEJMicm1800360DOI Listing
December 2018
5 Reads

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis.

Int J Mol Sci 2018 Dec 19;19(12). Epub 2018 Dec 19.

Department of Biology and Medical Parasitology, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.

The pathological process occurring within the central nervous system (CNS) as a result of the infection by spp. is not fully understood. Therefore, the aim of this study was to determine whether spp. Read More

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http://www.mdpi.com/1422-0067/19/12/4128
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http://dx.doi.org/10.3390/ijms19124128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321078PMC
December 2018
4 Reads

[Surveillance data on notifiable infectious diseases among students aged 6-22 years in China, 2011-2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Dec;39(12):1589-1595

Division of Infectious Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze the epidemiological characteristics of notifiable infectious diseases among Chinese students from 2011 to 2016 and to provide reference for the effective prevention and control programs on infectious disease among students. Both morbidity and mortality of notifiable infectious diseases among Chinese students aged 6-22 years from 2011 to 2016 were analyzed, with main characteristics of the disease described. During 2011 to 2016, morbidities of Categories A, B and C infectious diseases among the Chinese students aged 6-22 years showed a decreasing trend, from 248. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.12.010DOI Listing
December 2018
14 Reads

Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist by Screening of Microbial Secondary Metabolites.

Front Cell Infect Microbiol 2018 5;8:409. Epub 2018 Dec 5.

Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Amebiasis is caused by infection with the protozoan parasite . Although metronidazole has been a drug of choice against amebiasis for decades, it shows side effects and low efficacy against asymptomatic cyst carriers. In addition, metronidazole resistance has been documented for bacteria and protozoa that share its targets, anaerobic energy metabolism. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00409
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http://dx.doi.org/10.3389/fcimb.2018.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290340PMC
December 2018
7 Reads

analyses for potential key genes associated with gastric cancer.

PeerJ 2018 7;6:e6092. Epub 2018 Dec 7.

Department of Clinical Laboratory, Clinical College, Dali University, Dali, Yunnan, China.

Background: Understanding hub genes involved in gastric cancer (GC) metastasis could lead to effective approaches to diagnose and treat cancer. In this study, we aim to identify the hub genes and investigate the underlying molecular mechanisms of GC.

Methods: To explore potential therapeutic targets for GC,three expression profiles (GSE54129, GSE33651, GSE81948) of the genes were extracted from the Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.7717/peerj.6092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287586PMC
December 2018
1 Read

and keratitis in a contact lens user.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Microbiology, Aravind Eye Hospital Coimbatore, Coimbatore, Tamil Nadu, India.

The oomycete and the protozoan can cause fulminant and recalcitrant keratitis, respectively. These infections are not only sight-threatening but can also threaten the structural integrity of the eye. A high index of suspicion is required to identify keratitis given its uncommon occurrence. Read More

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http://dx.doi.org/10.1136/bcr-2018-226386DOI Listing
December 2018
3 Reads

Acanthamoeba profilin elicits allergic airway inflammation in mice.

PLoS Negl Trop Dis 2018 12 17;12(12):e0006979. Epub 2018 Dec 17.

Department of Parasitology School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do, South Korea.

Background: In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13-15 kDa Acanthamoeba unknown allergen.

Objective: We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312355PMC
December 2018
5 Reads

Dual 0.02% chlorhexidine digluconate - 0.1% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment.

Int J Pharm 2019 Feb 12;556:330-337. Epub 2018 Dec 12.

Service Pharmaceutique, Plateforme Fripharm, Groupe Hospitalier Centre Edouard Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, F-69437 Lyon Cedex 03, France; Université de Lyon, Laboratoire de Pharmacie Galénique Industrielle, UMR-CNRS 5305, Plateforme Fripharm, ISPB-Faculté de Pharmacie, Université Claude Bernard Lyon 1, 8, Avenue Rockefeller, F-69373 Lyon Cedex 08, France. Electronic address: http://fripharm.com.

Poor bioavailability and low residence time limit the efficiency of conventional biguanide-based eye drops against Acanthamoeba keratitis. The aim of this work was to formulate an original anti-amoebic thermoreversible ocular gel combining biguanide and metalloproteases inhibitor - chelating agent. Chlorhexidine digluconate (CHX)-ethylenediaminetetraacetic acid disodium salt (NaEDTA) were compounded in poloxamer 407 saline solution. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.016DOI Listing
February 2019
1 Read

Identification of the gene encoding the TATA box-binding protein-associated factor 1 (TAF1) and its putative role in the heat shock response in the protozoan parasite Entamoeba histolytica.

Parasitol Res 2019 Feb 15;118(2):517-538. Epub 2018 Dec 15.

Departamento de Biología Celular, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, Ciudad de México, Mexico.

Transcription factor IID (TFIID) is a cornerstone in the transcription initiation in eukaryotes. It is composed of TBP and approximately 14 different subunits named TBP-associated factors (TAFs). TFIID has a key role in transcription of many genes involved in cell proliferation, cell growth, cell cycle, cell cycle checkpoint, and various other processes as well. Read More

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http://dx.doi.org/10.1007/s00436-018-6170-6DOI Listing
February 2019
6 Reads
2.327 Impact Factor

Leptin Functions in Infectious Diseases.

Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.

Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275238PMC
November 2018
5 Reads
5.500 Impact Factor

Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child.

Turk J Pediatr 2018 ;60(3):340-343

Division of Infectious Diseases, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.

Sütçü M, Aktürk H, Gülümser-Şişko S, Acar M, Erol OB, Somer A, Bilgiç B, Salman N. Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child. Turk J Pediatr 2018; 60: 340-343. Read More

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http://dx.doi.org/10.24953/turkjped.2018.03.019DOI Listing
February 2019
6 Reads

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica.

PLoS Pathog 2018 11 30;14(11):e1007466. Epub 2018 Nov 30.

Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

Amebiasis is caused by the protozoan parasite Entamoeba histolytica (Eh), a potentially fatal disease occurring mainly in developing countries. How Eh interacts with innate host factors in the gut is poorly understood. Eh resides and feed in/on the outer colonic mucus layer and thus share an ecological niche with indigenous microbiota. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268003PMC
November 2018
7 Reads

Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.

Exp Parasitol 2019 Jan 22;196:22-27. Epub 2018 Nov 22.

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Island, Spain.

Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.11.005DOI Listing
January 2019
3 Reads