14,468 results match your criteria Amebiasis

An Infrequently Witnessed Case of Colitis.

Am J Med 2021 May 1. Epub 2021 May 1.

Department of Medicine, Eisenhower Health, Rancho Mirage, CA; Department of Medicine, University of California, Riverside, CA.

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The roles of parasite-derived extracellular vesicles in disease and host-parasite communication.

Parasitol Int 2021 Apr 29:102373. Epub 2021 Apr 29.

Healthy Longevity Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, MD4, 5 Science Drive 2, Singapore 117545, Singapore. Electronic address:

In recent years, several parasites have been shown to interact with their hosts through intra- and inter-community communication mechanisms, which were identified to be mediated by extracellular vesicles (EVs) through various uptake mechanisms. EVs are a heterogenous group of nanoparticles (~30-5000 nm) classified into three main types according to their size and biogenesis. EVs contain proteins, lipids, nucleic acids and metabolites from the cell of origin which are essential for genetic exchange, biomarker identification and diagnosis of pathological diseases. Read More

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Multilocus sequence typing (MLST) of Entamoeba histolytica identifies kerp2 as a genetic marker associated with disease outcomes.

Parasitol Int 2021 Apr 29;83:102370. Epub 2021 Apr 29.

Division of Parasitology, ICMR-National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata 700010, West Bengal, India. Electronic address:

Amoebiasis caused by protozoan parasite Entamoeba histolytica has diverse infection outcomes. The relationship between parasite genotypes and outcome of amoebic infection is still a paradox and needs to be explored. Genome information of infecting strains from endemic areas throughout the world is essential to explore this relation. Read More

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Diseases Caused by Amoebae in Fish: An Overview.

Animals (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia and Servei de Diagnòstic Patològic en Peixos, Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.

Parasitic and amphizoic amoebae are ubiquitous and can affect a huge variety of hosts, from invertebrates to humans, and fish are not an exception. Most of the relationships between amoebae and fish are based on four different types: ectocommensals, ectoparasites, endocommensals and endoparasites, although the lines between them are not always clear. As ectocommensals, they are located specially on the gills and particularly the amphizoic is the most relevant species, being a real pathogenic parasite in farmed salmon. Read More

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Two StAR-related lipid transfer proteins play specific roles in endocytosis, exocytosis, and motility in the parasitic protist Entamoeba histolytica.

PLoS Pathog 2021 Apr 28;17(4):e1009551. Epub 2021 Apr 28.

Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Lipid transfer proteins (LTPs) are the key contributor of organelle-specific lipid distribution and cellular lipid homeostasis. Here, we report a novel implication of LTPs in phagocytosis, trogocytosis, pinocytosis, biosynthetic secretion, recycling of pinosomes, and motility of the parasitic protist E. histolytica, the etiological agent of human amoebiasis. Read More

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species infection in patients seeking treatment for diarrhea and abdominal discomfort in Mukuru informal settlement in Nairobi, Kenya.

Food Waterborne Parasitol 2021 Jun 29;23:e00122. Epub 2021 Mar 29.

Centre for Microbiology Research, Kenya Medical Research Institute, P.O. Box 19464 00202, Nairobi, Kenya.

is the only pathogenic species of the genus and is morphologically identical to / ( complex) hence cannot be microscopically differentiated. The other spp. found in humans ( and ) can be differentiated morphologically from this complex. Read More

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Pseudomembranous Colitis Due to Intestinal Amebiasis.

Intern Med 2021 Apr 26. Epub 2021 Apr 26.

Department of General Internal Medicine and Infectious Diseases, National Hospital Organization Tokyo Medical Center, Japan.

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Perianal amebiasis cutis masked by giant condyloma acuminatum in a HIV-seropositive patient.

J Dermatol 2021 Apr 22. Epub 2021 Apr 22.

Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan.

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Monocyte dysregulation: consequences for hepatic infections.

Semin Immunopathol 2021 Apr 7. Epub 2021 Apr 7.

Department of Molecular Biology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Liver disorders due to infections are a substantial health concern in underdeveloped and industrialized countries. This includes not only hepatotropic viruses (e.g. Read More

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J Zoo Wildl Med 2021 Apr;52(1):310-314

Phoenix Zoo, Arizona Center for Nature Conservation, Phoenix, AZ 85008, USA.

Granulomatous amoebic encephalitis caused by the free-living amoeba is a highly fatal disease that was first isolated from a mandrill (), and has since been diagnosed in several nonhuman primates including orangutans. Indirect immunofluorescence antibody (IFA) techniques for have been used in the fields of human medicine and epidemiology both for exposure assessment and screening of clinical patients for antemortem diagnosis. Stored serum samples from five captive Northwest Bornean orangutans (), including one who had died from infection, housed at a single facility were screened with a human IFA assay for . Read More

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J Zoo Wildl Med 2021 Apr;52(1):232-240

Wildlife Conservation Society, Zoological Health Program, Bronx, NY 10460, USA,

Amoebiasis is a significant protozoal disease of reptiles causing nonspecific clinical signs including diarrhea, anorexia, and lethargy. It frequently results in acute death. Investigation of the pathophysiology of amoebiasis in reptiles has been hampered by the inability to accurately identify amoeba to the species level using conventional techniques. Read More

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J Zoo Wildl Med 2021 Apr;52(1):166-175

Northwest ZooPath, Monroe, WA 98272, USA,

A retrospective study was performed by reviewing all spp. submissions to Northwest ZooPath from 1996 to 2019. Necropsy and biopsy specimens from 106 captive Gila monsters () and 49 captive beaded lizards () were reviewed. Read More

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Evaluation of the PEIII-LC3-KDEL3 Chimeric Protein of Lectin as a Vaccine Candidate against Amebic Liver Abscess.

J Immunol Res 2021 20;2021:6697900. Epub 2021 Mar 20.

Departamento de Morfología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, C. P. 20131., Aguascalientes, Ags., Mexico.

is an intestinal parasite that causes dysentery and amebic liver abscess. has the capability to invade host tissue by union of virulence factor Gal/GalNAc lectin; this molecule induces an adherence-inhibitory antibody response as well as to protect against amebic liver abscess (ALA). The present work showed the effect of the immunization with PEIII-LC3-KDEL3 recombinant protein. Read More

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Taxon-Specific Proteins of the Pathogenic Species and .

Front Cell Infect Microbiol 2021 19;11:641472. Epub 2021 Mar 19.

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

The human protozoan parasite can live in the human intestine for months or years without generating any symptoms in the host. For unknown reasons, amoebae can suddenly destroy the intestinal mucosa and become invasive. This can lead to amoebic colitis or extraintestinal amoebiasis whereby the amoebae spread to other organs the blood vessels, most commonly the liver where abscesses develop. Read More

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An Integrated Data Analysis of mRNA, miRNA and Signaling Pathways in Pancreatic Cancer.

Biochem Genet 2021 Apr 3. Epub 2021 Apr 3.

Division of Molecular Cell Biology, Department of Biology, Shiraz University, Shiraz, Iran.

Although many genes and miRNAs have been reported for various cancers, pancreatic cancer's specific genes or miRNAs have not been studied precisely yet. Therefore, we have analyzed the gene and miRNA expression profile of pancreatic cancer data in the gene expression omnibus (GEO) database. The microarray-derived miRNAs and mRNAs were annotated by gene ontology (GO) and signaling pathway analysis. Read More

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Diversity, geographical distribution, and prevalence of Entamoeba spp. in Brazil: a systematic review and meta-analysis.

Parasite 2021 30;28:17. Epub 2021 Mar 30.

Faculty Estacio of Pantanal (Estacio FAPAN), São Luís, 2522 St - Cidade Nova, Caceres, 78201-000 Mato Grosso, Brazil.

The genus Entamoeba includes a variety of widely distributed species adapted to live in the digestive tracts of humans and a large variety of animals of different classes. The objective of this study was to investigate the prevalence, distribution, and molecular epidemiology of Entamoeba spp. in different classes of hosts in Brazil. Read More

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-Gut Microbiota Interaction: More Than Meets the Eye.

Serge Ankri

Microorganisms 2021 Mar 12;9(3). Epub 2021 Mar 12.

Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Haifa 31096, Israel.

Amebiasis is a disease caused by the unicellular parasite . In most cases, the infection is asymptomatic but when symptomatic, the infection can cause dysentery and invasive extraintestinal complications. In the gut, feeds on bacteria. Read More

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Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer ().

Biology (Basel) 2021 Mar 13;10(3). Epub 2021 Mar 13.

Tissue Architecture and Regeneration Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK.

The reindeer (caribou) is a Cervidae in the order Artiodactyla. Reindeer are sedentary and migratory populations with circumpolar distribution in the Arctic, Northern Europe, Siberia and North America. Reindeer are an important wild and domesticated species, and have developed various adaptive strategies to extreme environments. Read More

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Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt.

Int J Pharm Compd 2021 Mar-Apr;25(2):169-175

College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana, United States.

Metronidazole is indicated for the treatment of trichomoniasis, amebiasis, and anaerobic bacterial infections. The dosage regimen of metronidazole needs to be individualized in the treatment of trichomoniasis, in patients with hepatic impairment, and in pediatric as well as geriatric patients. A review of the therapeutic uses of metronidazole reveals the need for flexibility in dosing. Read More

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(-)-Epicatechin protects from amebic liver abscess development in hamster.

Exp Parasitol 2021 May 24;224:108103. Epub 2021 Mar 24.

Laboratorio de Biomedicina Molecular 2. Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Ciudad de México, México. Electronic address:

In this work the effect of (-)-epicatechin on the development of amebic liver abscess in hamsters was evaluated. (-)-epicatechin is a flavonoid present in plants that possesses various biological properties, including its activity against some protozoal parasites; however its antiamebic activity in a living model had not been evaluated. Syrian golden hamsters were intrahepatically inoculated with 1x10E. Read More

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Acute abdominal syndrome revealing an intestinal amoebiasis: Report of two cases in Tunisia.

Int J Surg Case Rep 2021 Feb 20;79:466-469. Epub 2021 Jan 20.

General Surgery Department, Hopital La Rabta, Tunis, Tunisia; Infectious Diseases Department, Hopital La Rabta, Tunis, Tunisia; University of Tunis El Manar, Faculty of Medicine of Tunis, Tunisia.

Amoebiasis is a parasitosis, mainly caused by Entamoeba histolytica (E. histolytica). It is a common disease in tropical and subtropical regions. Read More

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February 2021

Pondicherry declaration on the identification and detection of .

Trop Parasitol 2020 Jul-Dec;10(2):71-73. Epub 2021 Jan 25.

Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

Stake holders meet on "Identification and Detection of " was conducted on July 21, 2019 at Sri Balaji Vidyapeeth Deemed-to-be-University, Pondicherry. This programme was of national importance, since the amoebiasis is being increasingly reported from different parts of India because of poor socioeconomic conditions and sanitation levels. Experts in amoebiasis research across India attended this meeting. Read More

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January 2021

Multiple colon ulcers in a patient with HIV: Do not forget amoebiasis.

Int J Infect Dis 2021 Apr 15;105:411-412. Epub 2021 Mar 15.

Department of Pathology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.

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Amoebic colitis: A case series of a recurring missed diagnosis.

JGH Open 2021 Mar 22;5(3):404-407. Epub 2020 Dec 22.

Department of Gastroenterology Monash Health Clayton Victoria Australia.

, a pathogenic protozoan that causes amoebiasis, remains the second leading cause of death from parasitic infections worldwide. We present a case series of patients presenting to metropolitan tertiary gastroenterology units in Melbourne, Australia, highlighting the complexities of diagnosing amoebic colitis and the potential for misdiagnosis. These cases illustrate four key lessons in the identification of amoebic colitis: (i) obtaining a thorough travel and exposure history, (ii) having a high index of suspicion, (iii) understanding the limitations of available investigations, and (iv) being aware that amoebic colitis may masquerade as other common conditions. Read More

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Stage-Specific Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Parasites.

mSphere 2021 03 17;6(2). Epub 2021 Mar 17.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

Amoebiasis is a parasitic disease caused by infection and is a serious public health problem worldwide due to ill-prepared preventive measures as well as its high morbidity and mortality rates. Amoebiasis transmission is solely mediated by cysts. Cysts are produced by the differentiation of proliferative trophozoites in a process termed "encystation. Read More

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[Current view on Blastocystis species: clinical forms, diagnosis and treatment].

Ter Arkh 2020 Dec 26;92(11):86-90. Epub 2020 Dec 26.

People's Friendship University of Russia.

The symptomatic form of Blastocystis spp. infection not only with mild diarrhea or dysentery-like syndrome, but also with the development of severe ulcerative necrotic lesions of the intestine. Meanwhile, the pathogenicity of these microorganisms should not be exaggerated, due to majority asymptomatic cases or infection transmission with minor impaired bowel function. Read More

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December 2020

Revisiting Drug Development Against the Neglected Tropical Disease, Amebiasis.

Front Cell Infect Microbiol 2020 24;10:628257. Epub 2021 Feb 24.

Multidisciplinary Centre for Advanced Research and Studies, Jamia Millia Islamia, New Delhi, India.

Amebiasis is a neglected tropical disease which is caused by the protozoan parasite . This disease is one of the leading causes of diarrhea globally, affecting largely impoverished residents in developing countries. Amebiasis also remains one of the top causes of gastrointestinal diseases in returning international travellers. Read More

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February 2021

Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E.

Antiviral Res 2021 05 10;189:105056. Epub 2021 Mar 10.

National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India. Electronic address:

Emetine is a FDA-approved drug for the treatment of amebiasis. Previously we demonstrated the antiviral efficacy of emetine against some RNA and DNA viruses. In this study, we evaluated the in vitro antiviral efficacy of emetine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and found it to be a low nanomolar (nM) inhibitor. Read More

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Development of diffractive optics technology-based immunoassay protocol and its application in the detection of Entamoeba histolytica infections.

J Immunol Methods 2021 Jun 6;493:113016. Epub 2021 Mar 6.

Pathogen-Host-Environment Interactions Research Laboratory, Institute of Biology, College of Science, University of the Philippines Diliman, Quezon City 1101, Philippines. Electronic address:

Amebiasis due to infection with Entamoeba histolytica is a problematic parasitic disease in many countries. By means of a novel technology developed by Axela Biosensors, Inc., the dotLab™ system, a rapid immunoassay was developed to detect at least 5. Read More

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Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator.

mBio 2021 03 9;12(2). Epub 2021 Mar 9.

Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel

Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. Eukaryotes lack pathways to synthesize queuine, the nucleobase precursor to queuosine, and must obtain it from diet or gut microbiota. Here, we describe the effects of queuine on the physiology of the eukaryotic parasite , the causative agent of amebic dysentery. Read More

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