13,828 results match your criteria Amebiasis


EhFP10: A FYVE family GEF interacts with myosin IB to regulate cytoskeletal dynamics during endocytosis in Entamoeba histolytica.

PLoS Pathog 2019 Feb 19;15(2):e1007573. Epub 2019 Feb 19.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

Motility and phagocytosis are key processes that are involved in invasive amoebiasis disease caused by intestinal parasite Entamoeba histolytica. Previous studies have reported unconventional myosins to play significant role in membrane based motility as well as endocytic processes. EhMyosin IB is the only unconventional myosin present in E. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007573DOI Listing
February 2019

Transcriptomic and microbiota response on Litopenaeus vannamei intestine subjected to acute sulfide exposure.

Fish Shellfish Immunol 2019 Feb 14. Epub 2019 Feb 14.

Key Laboratory of South China Sea Fishery Resources Exploitation & Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fishery Ecology and Environment, Guangdong Province, PR China; South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, 510300, PR China. Electronic address:

Harmful effects of water pollutants are myriad. Sulfide from water bodies affects the aquatic animals. Intestine barrier function serves as the front-line of animals defense. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.02.021DOI Listing
February 2019

Vorinostat, a possible alternative to Metronidazole for the treatment of amebiasis caused by Entamoeba histolytica.

J Biomol Struct Dyn 2019 Feb 12:1-9. Epub 2019 Feb 12.

d Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda La Concepción S/N Carretera Pachuca-Actopan , San Agustín Tlaxiaca , Hidalgo , México .

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http://dx.doi.org/10.1080/07391102.2019.1578693DOI Listing
February 2019

Amebic colonic stricture: An unusual presentation.

Trop Parasitol 2018 Jul-Dec;8(2):98-100. Epub 2018 Dec 27.

Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

infection can lead to colitis, peri-colic abscess, ameboma, perforation and rarely colonic stricture. Amebic colitis is usually managed with medical management and rarely needs surgical management. We hereby report a case of colonic amebiasis, presenting as a stricture in transverse colon, mimicking malignancy, and managed successfully. Read More

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http://dx.doi.org/10.4103/tp.TP_40_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329265PMC
December 2018
2 Reads

Cyclooxygenase-Like Protein Regulates Cysteine Protease Expression and Virulence.

Front Cell Infect Microbiol 2018 9;8:447. Epub 2019 Jan 9.

Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada.

The intestinal protozoan parasite () causes amebiasis associated with severe diarrhea and/or liver abscess. pathogenesis is multifactorial requiring both parasite virulent molecules and host-induced innate immune responses. -induced host pro-inflammatory responses plays a critical role in disease pathogenesis by causing damage to tissues allowing parasites access to systemic sites. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00447
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http://dx.doi.org/10.3389/fcimb.2018.00447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333869PMC
January 2019
9 Reads

Genotypic diversity of Acanthamoeba strains isolated from Chilean patients with Acanthamoeba keratitis.

Parasit Vectors 2019 Jan 25;12(1):58. Epub 2019 Jan 25.

Subdepartamento de Genética Molecular, Instituto de Salud Pública de Chile, Av. Marathon 1000, Ñuñoa, CP 7780050, Santiago, Chile.

Background: Acanthamoeba spp. are the causative agents of a severe keratitis occurring mainly in contact lens wearers. The genus comprises more than 24 species that are currently divided into 20 different genotypes (T1-T20) according to sequence variations in the 18S rRNA gene. Read More

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http://dx.doi.org/10.1186/s13071-019-3302-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346584PMC
January 2019
2 Reads

Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells.

Front Cell Infect Microbiol 2018 8;8:437. Epub 2019 Jan 8.

Programa en Biomedicina Molecular y Red de Biotecnología, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City, Mexico.

MicroRNAs (miRNAs) are small non-coding RNAs that function as negative regulators of gene expression. Recent evidences suggested that host cells miRNAs are involved in the progression of infectious diseases, but its role in amoebiasis remains largely unknown. Here, we reported an unexplored role for miRNAs of human epithelial colon cells during the apoptosis induced by . Read More

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http://dx.doi.org/10.3389/fcimb.2018.00437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333105PMC
January 2019
1 Read
2.620 Impact Factor

Genetic diversity and gene family expansions in members of the genus Entamoeba.

Genome Biol Evol 2019 Jan 21. Epub 2019 Jan 21.

Earlham Institute, Norwich Research Park, Norwich, NR4 7UH.

Amoebiasis is the third-most common cause of mortality worldwide from a parasitic disease. Whilst the primary aetiological agent of amoebiasis is the obligate human parasite Entamoeba histolytica, other members of the genus Entamoeba can infect humans and may be pathogenic. Here, we present the first annotated reference genome for Entamoeba moshkovskii, a species that has been associated with human infections, and compare the genomes of E. Read More

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http://dx.doi.org/10.1093/gbe/evz009DOI Listing
January 2019

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
3 Reads

Evaluation of the sensitivity to chlorhexidine, voriconazole and itraconazole of T4 genotype Acanthamoeba isolated from Mexico.

Exp Parasitol 2019 Feb 12;197:29-35. Epub 2019 Jan 12.

Faculty of Superior Studies Iztacala, UNAM. Tlalnepantla, State of Mexico, Mexico. Electronic address:

Free-living amoebae of the genus Acanthamoeba are the etiological agents of cutaneous lesions, granulomatous amoebic encephalitis (GAE) and amoebic keratitis (AK), which are chronic infections with poor prognosis if not diagnosed promptly. Currently, there is no optimal therapeutic scheme to eradicate the pathologies these protozoa cause. In this study we report the morphological and molecular identification of three species of the genus Acanthamoeba, belonging to T4 group; A. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.01.006DOI Listing
February 2019
2 Reads
1.859 Impact Factor

Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development.

Can J Gastroenterol Hepatol 2018 2;2018:4601420. Epub 2018 Dec 2.

Hospital Corporation of America, East Florida Division, Fort Lauderdale, FL, USA.

is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with remain asymptomatic, some present with amoebic colitis and disseminated disease. Read More

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http://dx.doi.org/10.1155/2018/4601420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304615PMC
December 2018
1 Read

Biological information analysis of differentially expressed genes in oral squamous cell carcinoma tissues in GEO database.

J BUON 2018 Nov-Dec;23(6):1662-1670

College of Computer Science, Sichuan University, Chengdu, Sichuan 610065, P.R.China.

Purpose: This study aimed to detect the differentially expressed genes between oral squamous cell carcinoma (OSCC) tissues and adjacent normal tissues, and perform pathway analysis and protein-protein interaction (PPI) analysis on differentially expressed genes (DEGs).

Methods: Gene Expression Omnibus (GEO) database related to human tumors was selected from the National Center for Biotechnology Information (NCBI), and GSE31056 and GSE3524, two microarrays containing OSCC gene expression data, were extracted from it. Analysis of differentially expressed genes in the two microarrays was performed using "R" software, and the volcanic map was drawn. Read More

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January 2019
1 Read

Analysis of dynamic molecular networks for pancreatic ductal adenocarcinoma progression.

Cancer Cell Int 2018 22;18:214. Epub 2018 Dec 22.

1Department of Pharmacy, Zhejiang Cancer Hospital, Hangzhou, 310022 China.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism underlying PDAC progression remains far from clear. Read More

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http://dx.doi.org/10.1186/s12935-018-0718-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303882PMC
December 2018
2 Reads
1.989 Impact Factor

Entamoeba gingivalis - prevalence and correlation with dental caries in children from rural and urban regions of Lublin Province, Eastern Poland.

Ann Agric Environ Med 2018 Dec 18;25(4):656-658. Epub 2017 Dec 18.

Chair and Department of Jaw Orthopaedics, Medical University of Lublin, Poland.

Introduction: Entamoeba gingivalis, as the name implies. typically lives around the gumline of the teeth in the tartar and gingival pockets of the oral cavity. Pathogenicity of protozoa in the oral cavity is not completely understood. Read More

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http://www.journalssystem.com/aaem/Entamoeba-gingivalis-the-
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http://dx.doi.org/10.26444/aaem/80403DOI Listing
December 2018
9 Reads

Effect of povidone iodine, chlorhexidine digluconate and toyocamycin on amphizoic amoebic strains, infectious agents of Acanthamoeba keratitis - a growing threat to human health worldwide.

Ann Agric Environ Med 2018 Dec 3;25(4):725-731. Epub 2018 Dec 3.

Department of Medical Biology, Medical University, Warsaw, Poland.

Introduction: Free-living amoebae, ubiquitous in outer environments, in predisposing circumstances may exist as parasites, infectious agents of Acanthamoeba keratitis. In recent decades, the vision-threatening corneal infection is a growing human health threat worldwide, including Poland. The applied therapy is often ineffective due to diagnostic mistakes, various pathogenicity of Acanthamoeba strains and high resistance of cysts to drugs; many agents with possible anti-amoebic activity are still being tested. Read More

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http://dx.doi.org/10.26444/aaem/99683DOI Listing
December 2018
39 Reads

Amebic Liver Abscess.

N Engl J Med 2018 Dec;379(23):2255

Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

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http://www.nejm.org/doi/10.1056/NEJMicm1800360
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http://dx.doi.org/10.1056/NEJMicm1800360DOI Listing
December 2018
2 Reads

[Surveillance data on notifiable infectious diseases among students aged 6-22 years in China, 2011-2016].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Dec;39(12):1589-1595

Division of Infectious Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To analyze the epidemiological characteristics of notifiable infectious diseases among Chinese students from 2011 to 2016 and to provide reference for the effective prevention and control programs on infectious disease among students. Both morbidity and mortality of notifiable infectious diseases among Chinese students aged 6-22 years from 2011 to 2016 were analyzed, with main characteristics of the disease described. During 2011 to 2016, morbidities of Categories A, B and C infectious diseases among the Chinese students aged 6-22 years showed a decreasing trend, from 248. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.12.010DOI Listing
December 2018
7 Reads

Discovery of Antiamebic Compounds That Inhibit Cysteine Synthase From the Enteric Parasitic Protist by Screening of Microbial Secondary Metabolites.

Front Cell Infect Microbiol 2018 5;8:409. Epub 2018 Dec 5.

Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Amebiasis is caused by infection with the protozoan parasite . Although metronidazole has been a drug of choice against amebiasis for decades, it shows side effects and low efficacy against asymptomatic cyst carriers. In addition, metronidazole resistance has been documented for bacteria and protozoa that share its targets, anaerobic energy metabolism. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00409
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http://dx.doi.org/10.3389/fcimb.2018.00409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290340PMC
December 2018
6 Reads

analyses for potential key genes associated with gastric cancer.

PeerJ 2018 7;6:e6092. Epub 2018 Dec 7.

Department of Clinical Laboratory, Clinical College, Dali University, Dali, Yunnan, China.

Background: Understanding hub genes involved in gastric cancer (GC) metastasis could lead to effective approaches to diagnose and treat cancer. In this study, we aim to identify the hub genes and investigate the underlying molecular mechanisms of GC.

Methods: To explore potential therapeutic targets for GC,three expression profiles (GSE54129, GSE33651, GSE81948) of the genes were extracted from the Gene Expression Omnibus (GEO) database. Read More

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http://dx.doi.org/10.7717/peerj.6092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287586PMC
December 2018
1 Read

Acanthamoeba profilin elicits allergic airway inflammation in mice.

PLoS Negl Trop Dis 2018 12 17;12(12):e0006979. Epub 2018 Dec 17.

Department of Parasitology School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do, South Korea.

Background: In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13-15 kDa Acanthamoeba unknown allergen.

Objective: We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312355PMC
December 2018
4 Reads

Identification of the gene encoding the TATA box-binding protein-associated factor 1 (TAF1) and its putative role in the heat shock response in the protozoan parasite Entamoeba histolytica.

Parasitol Res 2019 Feb 15;118(2):517-538. Epub 2018 Dec 15.

Departamento de Biología Celular, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, 07360, Ciudad de México, Mexico.

Transcription factor IID (TFIID) is a cornerstone in the transcription initiation in eukaryotes. It is composed of TBP and approximately 14 different subunits named TBP-associated factors (TAFs). TFIID has a key role in transcription of many genes involved in cell proliferation, cell growth, cell cycle, cell cycle checkpoint, and various other processes as well. Read More

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http://dx.doi.org/10.1007/s00436-018-6170-6DOI Listing
February 2019
6 Reads
2.327 Impact Factor

Leptin Functions in Infectious Diseases.

Front Immunol 2018 26;9:2741. Epub 2018 Nov 26.

Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States.

Leptin, a pleiotropic protein has long been recognized to play an important role in the regulation of energy homeostasis, metabolism, neuroendocrine function, and other physiological functions through its effects on the central nervous system (CNS) and peripheral tissues. Leptin is secreted by adipose tissue and encoded by the obese () gene. Leptin acts as a central mediator which regulates immunity as well as nutrition. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275238PMC
November 2018
2 Reads
5.500 Impact Factor

Defining cooperative roles for colonic microbiota and Muc2 mucin in mediating innate host defense against Entamoeba histolytica.

PLoS Pathog 2018 11 30;14(11):e1007466. Epub 2018 Nov 30.

Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.

Amebiasis is caused by the protozoan parasite Entamoeba histolytica (Eh), a potentially fatal disease occurring mainly in developing countries. How Eh interacts with innate host factors in the gut is poorly understood. Eh resides and feed in/on the outer colonic mucus layer and thus share an ecological niche with indigenous microbiota. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268003PMC
November 2018
5 Reads

Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome.

Exp Parasitol 2019 Jan 22;196:22-27. Epub 2018 Nov 22.

University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Island, Spain.

Acanthamoeba keratitis (AK) is a sight-threatening corneal infection. The early symptoms include redness, pain, photophobia and intense tearing. Chronic infection usually progresses to stromal inflammation, ring ulcers, corneal opacification and hypopyon. Read More

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http://dx.doi.org/10.1016/j.exppara.2018.11.005DOI Listing
January 2019
2 Reads

Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity.

J Med Chem 2018 Nov 23. Epub 2018 Nov 23.

Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis and trypanosomiasis, all urgently require improved treatment options. Recently, it has been shown that anti-tubercular bicyclic nitroimidazoles such as pretomanid and delamanid have potential as repurposed therapeutics for the treatment of visceral leishmaniasis. Here we show that pretomanid also possesses potent activity against Giardia lamblia and Entamoeba histolytica, thus expanding the therapeutic potential of nitroimidazo-oxazines. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311682PMC
November 2018
1 Read

Formate-nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport.

J Biol Chem 2019 Jan 19;294(2):623-631. Epub 2018 Nov 19.

From the Department of Pharmaceutical and Medicinal Chemistry, and

Microbial formate-nitrite transporter-type proteins (FNT) exhibit dual transport functionality. At neutral pH, electrogenic anion currents are detectable, whereas upon acidification transport of the neutral, protonated monoacid predominates. Physiologically, FNT-mediated proton co-transport is vital when monocarboxylic acid products of the energy metabolism, such as l-lactate, are released from the cell. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006340
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http://dx.doi.org/10.1074/jbc.RA118.006340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333897PMC
January 2019
14 Reads

Colonic perforation due to amebiasis, a rare and lethal complication.

J Surg Case Rep 2018 Nov 13;2018(11):rjy297. Epub 2018 Nov 13.

PGY2 Resident General Surgery, U.C.E, Quito, Ecuador.

Amebiasis is still a major healthcare concern, especially in developing countries like Ecuador. The lack of sanitary control and hygiene measures make parasites infections still a burden for patients and physicians. Despite infections due to this parasites are usually mild, severe infections and fatal outcomes although rare still occur. Read More

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http://dx.doi.org/10.1093/jscr/rjy297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232277PMC
November 2018
6 Reads

Synthetic bovine lactoferrin peptide Lfampin kills trophozoites by necrosis and resolves amoebic intracecal infection in mice.

Biosci Rep 2019 Jan 8;39(1). Epub 2019 Jan 8.

Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510, México, D.F., México

Amoebiasis caused by the protozoan parasite remains a public health problem in developing countries, making the identification of new anti-amoebic compounds a continuing priority. Previously, we have shown that lactoferrin (Lf) and several Lf-derived peptides exhibit anti-amoebic activity independently of their iron-binding activity. Here, we evaluated the amoebicidal effect of synthetic Lf-derived peptides Lfcin-B, Lfcin 17-30, and Lfampin, analyzed the mechanism of death induced by the peptides and determined their therapeutic effects on murine intestinal amoebiasis. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20180850
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http://dx.doi.org/10.1042/BSR20180850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328891PMC
January 2019
16 Reads

Highly Potent 1-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites.

Front Cell Infect Microbiol 2018 30;8:380. Epub 2018 Oct 30.

Department of Chemistry, Guru Nanak Dev University, Amritsar, India.

Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In order to develop alternative antimicrobials, a library of 1-1,2,3-triazole-tethered metronidazole-isatin conjugates was synthesized using Huisgen's azide-alkyne cycloaddition reaction and evaluated for their amebicidal, anti-trichomonal, and anti-giardial potential. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00380
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http://dx.doi.org/10.3389/fcimb.2018.00380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218680PMC
October 2018
6 Reads

Reassessing the Role of in Periodontitis.

Front Cell Infect Microbiol 2018 29;8:379. Epub 2018 Oct 29.

Science and Healthcare for Oral Welfare, Toulouse, France.

The protozoan resides in the oral cavity and is frequently observed in the periodontal pockets of humans and pets. This species of is closely related to the human pathogen , the agent of amoebiasis. Although is highly enriched in people with periodontitis (a disease in which inflammation and bone loss correlate with changes in the microbial flora), the potential role of this protozoan in oral infectious diseases is not known. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00379
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http://dx.doi.org/10.3389/fcimb.2018.00379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215854PMC
October 2018
7 Reads
2.620 Impact Factor

Association between Entamoeba histolytica infection and human leukocyte antigen HLA- DRB1.

Ann Med Surg (Lond) 2018 Dec 18;36:71-74. Epub 2018 Oct 18.

Al-Kindy College of Medicine, University of Baghdad, Iraq.

Background: is the parasitic amoeba which caused amebiasis in human and responsible of 100,000 deaths every year. There is currently no vaccine against this parasite. The innate and adaptive immunity are important in protection against infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183022
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http://dx.doi.org/10.1016/j.amsu.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215996PMC
December 2018
2 Reads

Use of Real-Time Polymerase Chain Reaction to Differentiate between Pathogenic and the Nonpathogenic in Ecuador.

Am J Trop Med Hyg 2019 Jan;100(1):81-82

Centre for Tropical Diseases, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.

Microscopic examination of stool samples has been considered to be the "gold standard" for diagnosis of intestinal parasites. Recently, polymerase chain reaction (PCR) has been approved by the World Health Organization as the method of choice for the diagnosis of . Of the 106 stool samples collected from the Esmeraldas and Pichincha provinces of Ecuador, all (100%) were positive for / by light microscopy, whereas using real-time PCR (RT-PCR) DNA amplification, 74 (69. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-1022
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http://dx.doi.org/10.4269/ajtmh.17-1022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335901PMC
January 2019
11 Reads

Can the pyruvate: ferredoxin oxidoreductase (PFOR) gene be used as an additional marker to discriminate among Blastocystis strains or subtypes?

Parasit Vectors 2018 Oct 29;11(1):564. Epub 2018 Oct 29.

Hospital General "Dr. Manuel Gea Gonzalez", Calzada de Tlalpan 4800, Ciudad de Mexico, 14080, Ciudad de Mexico, Mexico.

Background: Blastocystis spp. are the most prevalent intestinal eukaryotes identified in humans, with at least 17 genetic subtypes (ST) based on genes coding for the small-subunit ribosomal RNA (18S). It has been argued that the 18S gene should not be the marker of choice to discriminate between STs of these strains because this marker exhibits high intra-genomic polymorphism. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3141-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205798PMC
October 2018
7 Reads

Clinical and microscopic predictors of Entamoeba histolytica intestinal infection in travelers and migrants diagnosed with Entamoeba histolytica/dispar infection.

PLoS Negl Trop Dis 2018 10 29;12(10):e0006892. Epub 2018 Oct 29.

Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Amebiasis is a protozoal infection caused by Entamoeba histolytica, while the morphologically indistinguishable E. dispar is considered as non-pathogenic. Polymerase chain reaction (PCR) assays are necessary to differentiate both species. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006892
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http://dx.doi.org/10.1371/journal.pntd.0006892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233926PMC
October 2018
14 Reads

Prevalence of non-pathogenic types of gastrointestinal protozoa in population in Slovakia and their potential importance in the aspect of public health.

Acta Parasitol 2018 Dec;63(4):819-825

Department of Epidemiology, Faculty of Medicine, University of P. J. Šafárik, Šrobárova 2, 041 80 Košice, Slovak Republic.

The aim of the research was to determine the prevalence of non-pathogenic protozoa circulating in the human population of Slovakia. We particularly focused on the socially deprived areas with poor sanitation conditions, as they are one of the factors affecting the transmission of these infections. Within this study, 2760 people were coprologically screened for the presence of protozoan cysts. Read More

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http://www.degruyter.com/view/j/ap.2018.63.issue-4/ap-2018-0
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http://dx.doi.org/10.1515/ap-2018-0100DOI Listing
December 2018
7 Reads

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.

Semin Diagn Pathol 2018 Nov 16;35(6):370-380. Epub 2018 Oct 16.

Department of Pathology, St. Jude Medical Center, Fullerton, CA 92835, United States. Electronic address:

The alimentary tract serves as host to a large number of diseases. In the non-neoplastic group of disorders, conventional histochemistry continues to play an important diagnostic role. It is particularly important in recognizing specific infectious diseases, such as Helicobacter gastritis, Whipple disease, intestinal tuberculosis and other forms of mycobacteriosis, malakoplakia, intestinal spirochetosis, fungal enteritides, amebiasis, cryptosporidiosis, isosporiasis, and microsporidiosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07402570183009
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http://dx.doi.org/10.1053/j.semdp.2018.10.002DOI Listing
November 2018
21 Reads

Corneal "Plaque" formation after anti-acanthamoeba therapy in acanthamoeba keratitis.

Indian J Ophthalmol 2018 Nov;66(11):1623-1624

Department of Microbiology, Dr. Sapra's Lab, Gurugram, Haryana, India.

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http://dx.doi.org/10.4103/ijo.IJO_734_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213680PMC
November 2018
1 Read

Androgen-dependent immune modulation in parasitic infection.

Semin Immunopathol 2019 Mar 23;41(2):213-224. Epub 2018 Oct 23.

Department of Molecular Biology and Immunology, Molecular Infection Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Straße 74, 20359, Hamburg, Germany.

Parasitic infections modulate the immune system of the host, resulting in either immune tolerance or the induction of pro-inflammatory defense mechanisms against the pathogen. In both cases, sex hormones are involved in the regulation of the immune response, as they are present in the systemic circulation and can act on a wide variety of cell types, including immune cells. Men and women have a different milieu of sex hormones, and these hormones play a role in determining immune responses to parasitic infections. Read More

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http://dx.doi.org/10.1007/s00281-018-0722-9DOI Listing
March 2019
3 Reads

A colonic amoebic abscess mimicking colonic carcinoma.

Med J Malaysia 2018 Oct;73(5):334-335

University of Malaya, Faculty of Medicine, Department of Parasitology, Kuala Lumpur, Malaysia.

Amebiasis is one of the major causes of diarrhea in the developing countries and it can present with a wide range of gastrointestinal symptoms depending on the phase of infection. We described a case of 50 year-old male patient who presented with abdominal pain, diarrhea and vomiting. After right hemicolectomy for appendicular abscess with tumour over the ileum, histopathological examinations revealed numerous trophozoites of Entamoeba histolytica in a background of inflammations (Figure 1). Read More

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October 2018
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Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.

Technol Cancer Res Treat 2018 01;17:1533033818806905

1 Department of General Surgery, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Background: Cetuximab has been regularly added to the treatments for metastatic colorectal cancer worldwide. However, due to its therapeutic insensitivity and underlying mechanisms being largely unknown, the clinical implementation of cetuximab in colorectal cancer remains limited.

Methods: The gene expression profile GSE56386 was retrieved from the Gene Expression Omnibus database. Read More

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http://dx.doi.org/10.1177/1533033818806905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196627PMC
January 2018
9 Reads

Identification of free-living amoebae isolated from tap water in Istanbul, Turkey.

Exp Parasitol 2018 Dec 15;195:34-37. Epub 2018 Oct 15.

Molecular Parasitology, Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.

Free-living amoebae (FLA) are widely spread in the environment and also known to cause rare but often serious infections. The present work focuses on a local survey on FLA. It is essential to know the prevalence and distribution of these microorganisms in order to get infections caused by them under control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144894183014
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http://dx.doi.org/10.1016/j.exppara.2018.10.002DOI Listing
December 2018
12 Reads

Telomeric Repeat-Binding Factor Homologs in : New Clues for Telomeric Research.

Front Cell Infect Microbiol 2018 2;8:341. Epub 2018 Oct 2.

Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de Mexico, Mexico City, Mexico.

Telomeric Repeat Binding Factors (TRFs) are architectural nuclear proteins with critical roles in telomere-length regulation, chromosome end protection and, fusion prevention, DNA damage detection, and senescence regulation. , the parasite responsible of human amoebiasis, harbors three homologs of human TRFs, based on sequence similarities to their Myb DNA binding domain. These proteins were dubbed EhTRF-like I, II and III. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00341
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http://dx.doi.org/10.3389/fcimb.2018.00341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175992PMC
October 2018
11 Reads

Bioinformatics Analysis and Functional Prediction of Transmembrane Proteins in .

Genes (Basel) 2018 Oct 16;9(10). Epub 2018 Oct 16.

School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

is an invasive, pathogenic parasite causing amoebiasis. Given that proteins involved in transmembrane (TM) transport are crucial for the adherence, invasion, and nutrition of the parasite, we conducted a genome-wide bioinformatics analysis of encoding proteins to functionally classify and characterize all the TM proteins in . In the present study, 692 TM proteins have been identified, of which 546 are TM transporters. Read More

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http://dx.doi.org/10.3390/genes9100499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209943PMC
October 2018
1 Read

A Calcium/Cation Exchanger Participates in the Programmed Cell Death and Virulence of .

Front Cell Infect Microbiol 2018 1;8:342. Epub 2018 Oct 1.

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Mexico City, Mexico.

is the etiologic agent of human amoebiasis, disease that causes 40,000 to 100,000 deaths annually worldwide. The cytopathic activity as well as the growth and differentiation of this microorganism is dependent on both, extracellular and free cytoplasmic calcium. However, few is known about the proteins that regulate the calcium flux in this parasite. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174217PMC
October 2018
2 Reads

Seroprevalence data at a private teaching hospital in Kenya: An examination of Toxoplasma gondii, cytomegalovirus, rubella, hepatitis A, and Entamoeba histolytica.

PLoS One 2018 16;13(10):e0204867. Epub 2018 Oct 16.

Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya.

Background: Relevant seroprevalence data for endemic pathogens in a given region provide insight not only into a population's susceptibility to acute infection or risk for reactivation disease but also into the potential need for policy initiatives aimed at reducing these risks. Data from sub-Saharan Africa are sparse and since Aga Khan University Hospital Nairobi is an internationally accredited hospital equipped with a laboratory electronic medical record system, analysis of pertinent local seroprevalence data has been made possible.

Methods: We have analyzed serology data from laboratory electronic records at a 300 bed tertiary private teaching hospital in Kenya for the dates, 2008 to 2017 for Toxoplasma gondii, cytomegalovirus, and rubella, which were used primarily for antenatal screening. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191086PMC
October 2018
13 Reads

Epithelial Cells Expressing EhADH, An Adhesin, Exhibit Increased Tight Junction Proteins.

Front Cell Infect Microbiol 2018 28;8:340. Epub 2018 Sep 28.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.

In , the EhADH adhesin together with the EhCP112 cysteine protease, form a 124 kDa complex named EhCPADH. This complex participates in trophozoite adherence, phagocytosis and cytolysis of target cells. EhCPADH and EhCP112 are both involved on epithelium damage, by opening tight junctions (TJ) and reaching other intercellular junctions. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00340
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http://dx.doi.org/10.3389/fcimb.2018.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172307PMC
September 2018
14 Reads

Comparison of chlorhexidine disinfectant in vitro effect on environmental and ocular Acanthamoeba strains, the amoebic agents of human keratitis − an emerging sight-threatening corneal disease in Poland

Ann Parasitol 2018;64(3):229-233

Department of Medical Biology, Medical University of Warsaw, ul. Nowogrodzka 73, 02-018 Warsaw, Poland

Small amoebae belonging to the Acanthamoeba genus complete their life cycles in different environmental niches as free-living protists however some of them are facultative parasites that can cause severe disease in humans. The sight-threatening Acanthamoeba keratitis develops in immune-competent persons, mainly in contact lens wearers; it is detected with increasing frequency along with the spread of contact lens use. The high abundance of the amoebae in the environment is important for dispersion and transmission of the infections among humans. Read More

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http://dx.doi.org/10.17420/ap6403.157DOI Listing
February 2019
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Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate.

PLoS Pathog 2018 10 11;14(10):e1007295. Epub 2018 Oct 11.

Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa Israel.

Amebiasis, a global intestinal parasitic disease, is due to Entamoeba histolytica. This parasite, which feeds on bacteria in the large intestine of its human host, can trigger a strong inflammatory response upon invasion of the colonic mucosa. Whereas information about the mechanisms which are used by the parasite to cope with oxidative and nitrosative stresses during infection is available, knowledge about the contribution of bacteria to these mechanisms is lacking. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007295
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http://dx.doi.org/10.1371/journal.ppat.1007295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181410PMC
October 2018
3 Reads

The first Acanthamoeba keratitis case in the Midwest region of Brazil: diagnosis, genotyping of the parasite and disease outcome.

Rev Soc Bras Med Trop 2018 Sep-Oct;51(5):716-719

Laboratório de Estudos da Relação Parasito-Hospedeiro, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.

We report an Acanthamoeba keratitis case associated with the use of contact lens in a 28-year-old female from Brasília, Brazil. Samples from corneal scraping and contact lens case were used for culture establishment, PCR amplification, and partial sequencing (fragments of ~400kb) of small subunit rDNA; both culture and PCR were positive. The sequence analyses of the cornea and of isolates from the contact lens case showed similarity with the T4 genotype. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0037-8682-0010-2018DOI Listing
October 2018
7 Reads