14,196 results match your criteria Amebiasis


Immune Response to the Enteric Parasite .

Physiology (Bethesda) 2020 Jul;35(4):244-260

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

is a protozoan parasite responsible for amoebiasis, a disease with a high prevalence in developing countries. Establishing an amoebic infection involves interplay between pathogenic factors for invasion and tissue damage, and immune responses for protecting the host. Here, we review the pathogenicity of and summarize the latest knowledge on immune response and immune evasion mechanisms during amoebiasis. Read More

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http://dx.doi.org/10.1152/physiol.00038.2019DOI Listing

Cecal amebiasis mimicking inflammatory bowel disease.

J Int Med Res 2020 May;48(5):300060520922379

Western Medicine Division, Lam Wah Ee Hospital, Penang, Malaysia.

Amebiasis is a frequently occurring parasitic infection in South East Asia. We present a case of a 54-year-old man with right lower quadrant abdominal pain that persisted for longer than 1 year. He had been diagnosed with inflammatory bowel disease in Indonesia. Read More

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http://dx.doi.org/10.1177/0300060520922379DOI Listing

Antiprotozoal Activity against of Flavonoids Isolated from Kunth.

Molecules 2020 May 26;25(11). Epub 2020 May 26.

Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), Av. Universidad S/N, Cd. Universitaria, San Nicolás de los Garza, C.P. 66455 Nuevo León, Mexico.

Amebiasis caused by is nowadays a serious public health problem worldwide, especially in developing countries. Annually, up to 100,000 deaths occur across the world. Due to the resistance that pathogenic protozoa exhibit against commercial antiprotozoal drugs, a growing emphasis has been placed on plants used in traditional medicine to discover new antiparasitics. Read More

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http://dx.doi.org/10.3390/molecules25112464DOI Listing

Aptamers as a novel diagnostic and therapeutic tool and their potential use in parasitology

Biomedica 2020 05 1;40(Supl. 1):148-165. Epub 2020 May 1.

Instituto Colombiano de Medicina Tropical, Universidad CES, Medellín, Colombia.

Aptamers are single-stranded DNA or RNA sequences that adopt unique three-dimensional structures that allow them to recognize a specific target with high affinity. They can potentially be used for the diagnosis of diseases, as new therapeutic agents, for the detection of food risks, as biosensors, for the detection of toxins, and as drug carriers and nanoparticle markers, among other applications. To date, an aptamer called pegaptanib is the only aptamer approved by the Food and Drug Administration (FDA) for commercial use. Read More

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http://dx.doi.org/10.7705/biomedica.4765DOI Listing

Urinary amoebiasis.

Diagn Cytopathol 2020 May 22. Epub 2020 May 22.

Faculty of Pharmacy, University of Modena-Reggio Emilia, Modena, Italy.

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http://dx.doi.org/10.1002/dc.24480DOI Listing

Invasive amoebiasis: an unlikely mimic of appendicitis.

ANZ J Surg 2020 May 15. Epub 2020 May 15.

Department of HPB/Upper GI Surgery, Monash Medical Centre, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ans.16004DOI Listing

Amoebic Liver Abscess in Crohn Disease Treated With Ustekinumab.

Inflamm Bowel Dis 2020 May 14. Epub 2020 May 14.

University Center for Gastrointestinal and Liver Diseases, Clarunis, St. Clara Hospital and University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1093/ibd/izaa101DOI Listing

Morphological and motility features of the stable bleb driven monopodial form of and its importance in encystation.

Infect Immun 2020 May 11. Epub 2020 May 11.

Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

and its reptilian counterpart and encystation model formed a polarized monopodial morphology when treated with pentoxifylline. This morphology was propelled by retrograde flow of the cell surface resulting from a cyclic sol-gel conversion of cytoplasm and a stable bleb at the leading edge. Pentoxifylline treatment switched the unpolarized, adherent trophozoites to non-adherent, stable bleb-driven form and altered the motility pattern from slow and random to fast, directionally persistent, and highly chemotactic. Read More

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http://dx.doi.org/10.1128/IAI.00903-19DOI Listing

Gut microbiome communication with bone marrow regulates susceptibility to amebiasis.

J Clin Invest 2020 May 5. Epub 2020 May 5.

Division of Infectious Diseases and International Health, Department of Med, University of Virginia, Charlottesville, United States of America.

The microbiome provides resistance to infection. However, mechanisms for this are poorly understood. Here we demonstrate in a murine model that colonization with the intestinal bacterium Clostridium scindens provided protection from Entamoeba histolytica colitis via innate immunity. Read More

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http://dx.doi.org/10.1172/JCI133605DOI Listing

Averting transmission: A pivotal target to manage amoebiasis.

Chem Biol Drug Des 2020 Apr 30. Epub 2020 Apr 30.

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, India.

Amoebiasis is a parasitic infectious disease caused by the enteric protozoan Entamoeba histolytica, a leading basis of deaths accounted to parasites, succeeding malaria and schistosomiasis. Conventional treatment methodologies used to deal with amoebiasis mainly rely on the administration of anti-amoebic compounds and vaccines but are often linked with substantial side-effects on the patient. Besides, cases of development of drug resistance in protozoans have been recorded, contributing further to the reduction in the efficiency of the treatment. Read More

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http://dx.doi.org/10.1111/cbdd.13699DOI Listing

Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small Leucine-Rich proteoglycans hold the key?

Spine J 2020 Apr 25. Epub 2020 Apr 25.

Aravind Medical Research Foundation, Madurai 625020, India.

Background Context: Small leucine-rich proteoglycans (SLRPs) play an essential role in extracellular matrix (ECM) organization and function. Recently, dysregulation of SLRPs has been implicated in degenerative disc disease (DDD). An in-depth analysis using high-throughput proteomic sequencing might provide valuable information on their implications in health and disease. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.04.011DOI Listing

Answer to May 2020 Photo Quiz.

J Clin Microbiol 2020 Apr 23;58(5). Epub 2020 Apr 23.

Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore

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http://dx.doi.org/10.1128/JCM.00069-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180264PMC

DNA methylation biomarkers for nasopharyngeal carcinoma.

PLoS One 2020 9;15(4):e0230524. Epub 2020 Apr 9.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Aberrant methylation of DNA plays an important role in the pathogenesis of nasopharyngeal carcinoma (NPC). In the current study, we aimed to integrate three cohorts profile datasets to identify abnormally methylated-differentially expressed genes and pathways associated with NPC.

Methods: Data of gene expression microarrays (GSE53819, GSE412452) and gene methylation microarrays (GSE52068) obtained from the GEO database. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230524PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144954PMC

Anti-amebic effects of Chinese rhubarb () leaves' extract, the anthraquinone rhein and related compounds.

Heliyon 2020 Apr 1;6(4):e03693. Epub 2020 Apr 1.

Department of Biomedical & Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, United States.

infects 50 million people worldwide and causes 55 thousand fatalities every year. Current anti-amebic drugs (e.g. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118315PMC

Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses.

Pharmaceuticals (Basel) 2020 Mar 21;13(3). Epub 2020 Mar 21.

School of Pharmacy and Pharmacology, University of Tasmania, Hobart Tasmania 7001, Australia.

The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat amoebiasis in the treatment of COVID-19. Emetine had amongst the lowest reported half-maximal effective concentration (EC) from over 290 agents screened for the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) coronaviruses. Read More

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http://dx.doi.org/10.3390/ph13030051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151655PMC

Recent advances in nitroaromatics: The synthesis and development of anti-infective drugs.

Curr Pharm Des 2020 Mar 30. Epub 2020 Mar 30.

Centre of excellence for Pharmaceutical Pharmacen™, North-West University, Potchefstroom. South Africa.

Infectious diseases commonly occur in tropical and sub-tropical countries. The pathogens of such diseases are able to multiply in human hosts, warranting their continual survival. Infections that are commonplace include malaria, chagas, trypanosomiasis, giardiasis, amoebiasis, toxoplasmosis and leishmaniasis. Read More

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http://dx.doi.org/10.2174/1381612826666200331091853DOI Listing

EhRab21 associates with the Golgi apparatus in Entamoeba histolytica.

Parasitol Res 2020 May 26;119(5):1629-1640. Epub 2020 Mar 26.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del I.P.N., Avenida Instituto Politécnico Nacional No. 2508, Col. San Pedro Zacatenco, Delegación Gustavo A. Madero, CP 07360, Mexico City, Mexico.

Rab proteins constitute the largest group of small GTPases and act as molecular switches in a wide variety of cellular processes, including proliferation, cytoskeleton assembly, and membrane trafficking in all eukaryotic cells. Rab21 has been reported in several eukaryotic cells, and our results suggest that in Entamoeba histolytica, Rab21 is involved in the vesicular traffic associated with the Golgi apparatus, where its function appears to be important to maintain the structure of this organelle. In addition, proteins such as Rab1A and Sec24, identified in this work associated with EhRab21, participate in the traffic of COPII vesicles from the endoplasmic reticulum to the Golgi apparatus and are necessary to maintain the latter's structure in human cells. Read More

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http://dx.doi.org/10.1007/s00436-020-06667-7DOI Listing

Lipids in : Host-Dependence and Virulence Factors.

Front Cell Infect Microbiol 2020 10;10:75. Epub 2020 Mar 10.

Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico.

Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of , the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reach and attack the epithelia and ingest target cells. Synthesis and metabolism of lipids in this protozoan present remarkable difference with those performed by other eukaryotes. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075943PMC

Secreted Phosphoprotein 1 (SPP1) and Fibronectin 1 (FN1) Are Associated with Progression and Prognosis of Esophageal Cancer as Identified by Integrated Expression Profiles Analysis.

Med Sci Monit 2020 Mar 24;26:e920355. Epub 2020 Mar 24.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, China (mainland).

BACKGROUND Esophageal cancer is a malignant tumor with a complex pathogenesis and a poor 5-year survival rate, which encourages researchers to explore its molecular mechanisms deeper to improve the prognosis. MATERIAL AND METHODS DEGs were from 4 Gene Expression Omnibus (GEO) databases (GSE92396, GSE20347, GSE23400, and GSE45168) including 87 esophageal tumor samples and 84 normal samples. We performed Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Protein-Protein interaction (PPI) analysis, and GeneMANIA to identify the DEGs. Read More

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http://dx.doi.org/10.12659/MSM.920355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111131PMC

Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.

PLoS Negl Trop Dis 2020 03 20;14(3):e0008150. Epub 2020 Mar 20.

Division of Infectious Diseases, Department of Internal Medicine, Stanford University, Stanford, CA, United States of America.

Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple parasitic pathogens could improve the economic incentives for drug development as well as simplifying treatment regimens. We recently performed a screen of repurposed compounds against the protozoan parasite Entamoeba histolytica, causative agent of amebic dysentery, and identified four compounds (anisomycin, prodigiosin, obatoclax and nithiamide) with low micromolar potency and drug-like properties. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112225PMC

Two cases of endoscopically diagnosed amebic colitis treated with paromomycin monotherapy.

PLoS Negl Trop Dis 2020 03 19;14(3):e0008013. Epub 2020 Mar 19.

AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1371/journal.pntd.0008013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081979PMC

Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis.

Mol Genet Genomic Med 2020 Mar 17:e1200. Epub 2020 Mar 17.

Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Cervical cancer as one of the most common malignant tumors lead to bad prognosis among women. Some researches already focus on the carcinogenesis and pathogenesis of cervical cancer, but it is still necessary to identify more key genes and pathways.

Methods: Differentially expressed genes were identified by GEO2R from the gene expression omnibus (GEO) website, then gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyzed by DAVID. Read More

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http://dx.doi.org/10.1002/mgg3.1200DOI Listing

Insights into amebiasis using a human 3D-intestinal model.

Cell Microbiol 2020 Mar 16:e13203. Epub 2020 Mar 16.

Institut Pasteur, Paris, France.

Entamoeba histolytica is the causative agent of amebiasis, an infectious disease targeting the intestine and the liver in humans. Two types of intestinal infection are caused by this parasite: silent infection, which occurs in the majority of cases, and invasive disease, which affects 10% of infected persons. To understand the intestinal pathogenic process, several in vitro models, such as cell cultures, human tissue explants or human intestine xenografts in mice, have been employed. Read More

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http://dx.doi.org/10.1111/cmi.13203DOI Listing

Entamoeba histolytica infections in wild and semi-wild orangutans in Sumatra and Kalimantan.

Am J Primatol 2020 May 16;82(5):e23124. Epub 2020 Mar 16.

Department of Botany and Zoology, Masaryk University, Brno, Czech Republic.

Key to the success of orangutan conservation management practices is the prevention of the introduction of infectious diseases to the remaining populations. Previous reports of Entamoeba spp. positive orangutans are of concern as Entamoeba spp. Read More

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http://dx.doi.org/10.1002/ajp.23124DOI Listing
May 2020
2.435 Impact Factor

Prevalence and distribution of Entamoeba species in a rural community in northern South Africa.

Food Waterborne Parasitol 2020 Mar 20;18:e00076. Epub 2020 Feb 20.

Medical Laboratory Sciences Department, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Amoebiasis occurs worldwide and affects about 20-50 million people annually. Stool samples were collected from patients attending different rural clinics in Northern South Africa in the present study. Microscopic examination was performed for the initial detection of parasites. Read More

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http://dx.doi.org/10.1016/j.fawpar.2020.e00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058707PMC

Natural Honey-Induced .

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):243-245. Epub 2020 Jan 29.

Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Natural honey in spite of its usefulness is known to contain certain microorganisms. In the present study, we describe a case of after using topical honey administered by a traditional medicine therapist. A 32-year-old male came with red eye and blurred vision. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_56_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034153PMC

Determinants of Anemia among HIV-Positive Children on Highly Active Antiretroviral Therapy Attending Hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A Case-Control Study.

Anemia 2020 18;2020:3720572. Epub 2020 Feb 18.

Woldia University, Faculty of Health Sciences, Department of Nursing, P.O.Box 400, Woldia, Ethiopia.

. Anemia is one of the most commonly observed hematological abnormalities and an independent poor prognostic marker of HIV disease. The rate of progression and mortality in this subgroup of patients is high compared to nonanemic patients. Read More

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http://dx.doi.org/10.1155/2020/3720572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049326PMC
February 2020

Identification of 2 Potential Core Genes for Influence of Gut Probiotics on Formation of Intracranial Aneurysms by Bioinformatics Analysis.

Med Sci Monit 2020 Mar 6;26:e920754. Epub 2020 Mar 6.

Department of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China (mainland).

BACKGROUND Rupture of intracranial aneurysms (IA) is associated with high rates of mortality around the world. Use of intestinal probiotics can regulate the pathophysiology of aneurysms, but the details of the mechanism involved have been unclear. MATERIAL AND METHODS The GEO2R analysis website was used to detect the DEGs between IAs, AAAs, samples after supplementation with probiotics, and normal samples. Read More

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http://dx.doi.org/10.12659/MSM.920754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077060PMC

Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica.

PLoS One 2020 5;15(3):e0219870. Epub 2020 Mar 5.

Department of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.

Entamoeba histolytica is a food- and waterborne parasite that causes amebic dysentery and amoebic liver abscesses. Adhesion is one of the most important virulence functions as it facilitates motility, colonization of host, destruction of host tissue, and uptake of nutrients by the parasite. The parasite cell surface adhesin, the Gal/GalNAc lectin, facilitates parasite-host interaction by binding to galactose or N-acetylgalactosamine residues on host components. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219870PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058331PMC

Fulminant amebic colitis: An unusual postoperative complication of intraabdominal malignancy.

J Postgrad Med 2020 Apr-Jun;66(2):99-101

Department of Gastrointestinal Surgery, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

Amebiasis caused by protozoa Entamoeba histolytica (EH) is the third leading parasitic cause of human mortality. Although amebiasis is endemic in India, only about 10% of the infected individuals manifest disease. Clinical spectrum of amebiasis ranges from asymptomatic colonization to amebic colitis to hemorrhagic and fulminant colitis. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_605_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239400PMC

Role of kinases in virulence and pathogenesis of protozoan parasite .

Front Biosci (Landmark Ed) 2020 03 1;25:1617-1635. Epub 2020 Mar 1.

School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India,,

Protein kinases are known to regulate several cellular processes like metabolism, motility and endocytosis through phosphorylation of specific target proteins which forms a communication system relaying extracellular signals to intracellular milieu for an adaptive response. One of the protozoan parasite Entamoeba histolytica, which causes amoebiasis and is one of the prominent reason for causing diarrhoea in infants of developing countries, where it remains the third leading cause of deaths in infants(1). The genome of this parasite codes for 331 putative protein kinases which accounts for 3. Read More

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Heteroleptic Ni complexes: Synthesis, structural characterization, computational studies and amoebicidal activity evaluation.

J Inorg Biochem 2020 May 19;206:111043. Epub 2020 Feb 19.

Departamento de Química Inorgánica y Nuclear, Facultad de Química, UNAM, Ciudad Universitaria, Ciudad de México, Mexico. Electronic address:

In this work, we present the synthesis, characterization, electrochemical studies, DFT calculations, and in vitro amoebicidal effect of seven new heteroleptic Ni coordination compounds. The crystal structures of [H(pdto)](NO) and [Ni(pdto)(NO)]PF are presented, pdto = 2,2'-[1,2-ethanediylbis-(sulfanediyl-2,1-ethanediyl)]dipyridine. The rest of the compounds have general formulae: [Ni(pdto)(NN)](PF) where N-N = 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (44dmbpy), 5,5'-dimethyl-2,2'-bipyridine (55dmbpy), 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (47dmphen) and 5,6-dimethyl-1,10-phenanthroline (56dmphen). Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111043DOI Listing

Anti-amoebic Activity of Leaf Extracts and Aporphine Alkaloids Obtained from Annona purpurea.

Planta Med 2020 Apr 27;86(6):425-433. Epub 2020 Feb 27.

Department of Immunology, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México.

has been traditionally used by indigenous and socioeconomically disadvantaged people to treat infectious and parasitic diseases, including amoebiasis. The goal of this study was to assess the effect of a crude methanolic extract, an alkaloid extract, and aporphine alkaloids from leaves of on the viability of trophozoite cultures and to identify the mechanism of action. Different concentrations of the extracts and alkaloids purpureine (1: ), 3-hydroxyglaucine (2: ), norpurpureine (3: ) glaziovine (4: ), and oxopurpureine (5: ) were added to the cultures, and dead parasites were counted after 24 h using a tetrazolium dye reduction assay and analyzed by flow cytometry. Read More

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http://dx.doi.org/10.1055/a-1111-9566DOI Listing

Seroprevalence of at a voluntary counselling and testing centre in Tokyo: a cross-sectional study.

BMJ Open 2020 Feb 25;10(2):e031605. Epub 2020 Feb 25.

AIDS Clinical Center, National Center for Global Health and Medicine Hospital, Shinjuku-ku, Japan

Background: Amebiasis, which is caused by , is a re-emerging public health issue owing to sexually transmitted infection (STI) in Japan. However, epidemiological data are quite limited.

Methods: To reveal the relative prevalence of sexually transmitted infection to other STIs, we conducted a cross-sectional study at a voluntary counselling and testing (VCT) centre in Tokyo. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044870PMC
February 2020

Update on the major imported protozoan infections in travelers and migrants.

Future Microbiol 2020 Feb 17;15:213-225. Epub 2020 Feb 17.

National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Ctra Colmenar, Km 9,100, 28034, Madrid, Spain.

Globalization has contributed to the emergence of specific parasitic diseases in novel geographical areas, and in these regions, these infections in travelers and immigrants may cause a considerable burden of disease. Timely diagnosis and treatment of protozoan infections to decrease mortality and prevent associated complications are essential. In this respect, the increased availability of specific DNA-detection procedures has improved the diagnosis of many imported parasitic infections. Read More

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http://dx.doi.org/10.2217/fmb-2019-0212DOI Listing
February 2020

[Epidemiological characteristics of amoebic dysentery in China, 2015-2018].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jan;41(1):90-95

Division of Infectious Disease Control and Prevention, Key Laboratory of Surveillance and Early Warning on Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To understand the characteristics and changes of the incidence of amoebic dysentery in China during 2015-2018, explore the causes of high incidence in some areas and provide a data base for the development of national prevention and control strategies and measures. Data were collected from the infectious disease reporting management information system from Chinese Disease Control and Prevention. To understand the seasonal, population and area distributions of amoebic dysentery, descriptive epidemiological method and software SPSS 16. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2020.01.017DOI Listing
January 2020

Liver abscess in «anchovy paste»; amebiasis alert.

Authors:
I Solares P Kessler

Rev Clin Esp 2020 Feb 10. Epub 2020 Feb 10.

Servicio de Medicina Interna, Hospital 12 de Octubre, Madrid, España.

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http://dx.doi.org/10.1016/j.rce.2019.05.021DOI Listing
February 2020

Functional characterization and subcellular distribution of two recombinant cytosolic HSP70 isoforms from Entamoeba histolytica under normal and stress conditions.

Parasitol Res 2020 Apr 13;119(4):1337-1351. Epub 2020 Feb 13.

Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, 04510, México, Mexico.

Amoebiasis is a human intestinal disease caused by the parasite Entamoeba histolytica. It has been previously demonstrated that E. histolytica heat shock protein 70 (EhHSP70) plays an important role in amoebic pathogenicity by protecting the parasite from the dangerous effects of oxidative and nitrosative stresses. Read More

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http://dx.doi.org/10.1007/s00436-020-06621-7DOI Listing

Formation of oxidised (OX) proteins in Entamoeba histolytica exposed to auranofin and consequences on the parasite virulence.

Cell Microbiol 2020 Jun 12;22(6):e13174. Epub 2020 Feb 12.

Department of Molecular Microbiology, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Metronidazole (MNZ), the first line drug for amoebiasis and auranofin (AF), an emerging antiprotozoan drug, are both inhibiting Entamoeba histolytica thioredoxin reductase. The nature of oxidised proteins (OXs) formed in AF- or MNZ-treated E. histolytica trophozoites is unknown. Read More

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http://dx.doi.org/10.1111/cmi.13174DOI Listing

Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity.

Eur J Med Chem 2020 Mar 22;189:112084. Epub 2020 Jan 22.

Laboratorio de Química Inorgánica Medicinal, Facultad de Química Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior s/n, CU, P.O. Box 70-360, 04510, México City, Mexico. Electronic address:

Herein is presented the synthesis, characterization, electrochemical studies, DFT calculations and in vitro evaluation of amoebicidal activity in trophozoites of Entamoeba histolytica of twenty ruthenium (II) mixed compounds with general formulae: [Ru(pdto)(E-E)]Cl (E-E bidentate, either neutral or negatively charged ligands). For compounds under study, O-O, N-O and N-N auxiliary donor ligands demonstrate to have a crucial impact on the electronic properties and that it is possible to modulate the antiparasitic activity. Among analyzed complexes, only four present a better performance compared to typically used metronidazole drug (IC < 6. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112084DOI Listing

Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but Not Phagocytosis.

J Infect Dis 2020 Apr;221(10):1734-1739

Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.

Background: Entamoeba histolytica kills human cells by ingesting fragments of live cells until the cell eventually dies, a process termed amebic trogocytosis. In a previous study, we showed that acidified amebic lysosomes are required for both amebic trogocytosis and phagocytosis, as well as cell killing.

Methods: Amebic cysteine proteases (CPs) were inhibited using an irreversible inhibitor, E-64d. Read More

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http://dx.doi.org/10.1093/infdis/jiz671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184912PMC

Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide.

Chest 2020 May 21;157(5):1100-1113. Epub 2020 Jan 21.

Department of Imaging, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Parasitoses are infectious diseases of global distribution, with predominance in areas of poor sanitation. Parasites cause damage through direct tissue injury and the inflammatory response generated by their migration and establishment in various organs. Thoracic involvement by parasitic disease can generate both specific and nonspecific clinical, laboratorial, and radiologic manifestations, which often makes their diagnosis challenging. Read More

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http://dx.doi.org/10.1016/j.chest.2019.12.025DOI Listing

A case of amoebic colitis with amoeboma and simultaneous liver abscesses. A diagnosis by colonoscopy.

Acta Gastroenterol Belg 2019 Oct-Dec;82(4):539-541

Department of Gastroenterology and Hepatology, General Hospitals Turnhout, Belgium.

A 50-year-old patient was admitted to our department after developing severe abdominal cramps, watery diarrhea and fever, during four days whilst travelling abroad. Imaging identified a mass in the ascending colon with simultaneous liver lesions. Initially a diagnosis of metastatic colorectal cancer was suggested, however colonoscopy showed a large lesion with a central ulcer and surrounding inflammation in the ascending colon. Read More

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February 2020

Ultrasound-Enhanced Drug Delivery for Treatment of Acanthamoeba Keratitis.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:2504-2507

Reaching sufficient amounts of therapeutic agents in ocular tissues is a major challenge in ophthalmology. In this study, we examined the effects of ultrasound application for delivery of polyhexamethylene biguanide for treatment of Acanthamoeba keratitis. Ultrasound intensities of 0. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8856686DOI Listing

Identification of Entamoeba histolytica in Patients with Suspected Amebiasis in Jordan Using PCR-based Assays.

Pak J Biol Sci 2020 Jan;23(2):166-172

Background And Objective: Identification of Entamoeba histolytica (E. histolytica) by microscopy alone can be problematic because E. dispar and E. Read More

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http://dx.doi.org/10.3923/pjbs.2020.166.172DOI Listing
January 2020

[Early onset of metronidazole-induced peripheral neuropathy in a patient with amoebic colitis:a case report].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(1):72-77

Department of Gastroenterology, Matsushita Memorial Hospital.

Peripheral neuropathy reportedly develops after a long period of metronidazole administration. Here, we report a case of amoebic colitis in which peripheral neuropathy occurred approximately 24 hours after administering metronidazole. A 76-year-old man presented with mucous and bloody stool. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.72DOI Listing
January 2020

Copro-molecular study of Entamoeba infection among the indigenous community in Malaysia: A first report on the species-specific prevalence of Entamoeba in dogs.

Acta Trop 2020 Apr 9;204:105334. Epub 2020 Jan 9.

Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: Entamoeba is a free-living protozoan parasitic species that infect a variety of hosts. In humans, Entamoeba histolytica is the causative agent of amoebiasis. Entamoeba species has also been reported in dogs. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105334DOI Listing

Genetic diversity of Blastocystis in kindergarten children in southern Xinjiang, China.

Parasit Vectors 2020 Jan 10;13(1):15. Epub 2020 Jan 10.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, Henan, People's Republic of China.

Background: Blastocystis is one of the most common intestinal parasites in humans and various animals worldwide. Few studies are available regarding the genetic characterization of Blastocystis infections in humans in China.

Methods: In the present study, 609 fecal samples were collected from two- to six-year-old kindergarten children in southern Xinjiang and were examined by polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1186/s13071-020-3890-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954523PMC
January 2020
3.430 Impact Factor

Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants.

Expert Rev Anti Infect Ther 2020 Feb 15;18(2):127-143. Epub 2020 Jan 15.

National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain.

: Recent increases in population movements have created novel health challenges in many areas of the World, and health policies have been adapted accordingly in several countries. However, screening guidelines for infectious diseases are not standardized and generally do not include comprehensive screening for parasitic infections.: Malaria, Chagas disease, leishmaniasis, amebiasis, filariases, strongyloidiasis, and schistosomiasis are reviewed, focusing on the challenges posed for their diagnosis and management in vulnerable populations such as migrants. Read More

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http://dx.doi.org/10.1080/14787210.2020.1713099DOI Listing
February 2020