1,128 results match your criteria Ambulatory EEG


Hippocampal gamma predicts associative memory performance as measured by acute and chronic intracranial EEG.

Sci Rep 2019 Jan 24;9(1):593. Epub 2019 Jan 24.

New York University Comprehensive Epilepsy Center, 223 East 34th Street, New York, NY, 10016, USA.

Direct recordings from the human brain have historically involved epilepsy patients undergoing invasive electroencephalography (iEEG) for surgery. However, these measurements are temporally limited and affected by clinical variables. The RNS System (NeuroPace, Inc. Read More

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http://dx.doi.org/10.1038/s41598-018-37561-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345863PMC
January 2019

A Study on the Feasibility of the Deep Brain Stimulation (DBS) Electrode Localization Based on Scalp Electric Potential Recordings.

Front Physiol 2018 4;9:1788. Epub 2019 Jan 4.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Deep Brain Stimulation (DBS) is an effective therapy for patients disabling motor symptoms from Parkinson's disease, essential tremor, and other motor disorders. Precise, individualized placement of DBS electrodes is a key contributor to clinical outcomes following surgery. Electroencephalography (EEG) is widely used to identify the sources of intracerebral signals from the potential on the scalp. Read More

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http://dx.doi.org/10.3389/fphys.2018.01788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328462PMC
January 2019
1 Read

A miniature multi-contrast microscope for functional imaging in freely behaving animals.

Nat Commun 2019 01 9;10(1):99. Epub 2019 Jan 9.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, and dysregulated in neuropathologies such as brain tumors. Interrogating these phenomena in freely behaving animals requires a portable microscope with multiple optical contrast mechanisms. Therefore, we developed a miniaturized microscope with: a fluorescence (FL) channel for imaging neural activity (e. Read More

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http://dx.doi.org/10.1038/s41467-018-07926-zDOI Listing
January 2019
1 Read

The Diagnostic Utility of Ambulatory EEG Following Nondiagnostic Epilepsy Monitoring Unit Admissions.

J Clin Neurophysiol 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, U.S.A.

Purpose: Epilepsy monitoring unit (EMU) admissions provide a definitive diagnosis for approximately three-quarters of patients. However, many patients do not receive a definitive diagnosis following EMU admission. Ambulatory EEG following nondiagnostic EMU admissions was evaluated as a means of providing a diagnosis for these patients. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000559DOI Listing
January 2019
2 Reads

Two-Wired Current Modulator Active Electrode for Ambulatory Biosignal Recording.

IEEE Trans Biomed Circuits Syst 2019 Feb 20;13(1):15-25. Epub 2018 Dec 20.

This paper presents an innovative current modulator active electrode (CMAE) with only two outgoing wires that reduces cost and complexity of wearable bioamplifiers based on dry electrodes. The CMAE can be considered as an operational transconductance amplifier, which modulates the supply current by input voltage signal through its two supply rails. The CMAE prototype is implemented with only two discrete op-amps for ECG and EEG recording with current consumption of 60 μA and 100 μA, respectively. Read More

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http://dx.doi.org/10.1109/TBCAS.2018.2888996DOI Listing
February 2019

Non-pharmacological interventions for chronic pain in multiple sclerosis.

Cochrane Database Syst Rev 2018 12 19;12:CD012622. Epub 2018 Dec 19.

Department of Rehabilitation Medicine, Royal Melbourne Hospital, Royal Park Campus, Poplar Road, Parkville, Melbourne, Victoria, Australia, 3052.

Background: Chronic pain is common and significantly impacts on the lives of persons with multiple sclerosis (pwMS). Various types of non-pharmacological interventions are widely used, both in hospital and ambulatory/mobility settings to improve pain control in pwMS, but the effectiveness and safety of many non-pharmacological modalities is still unknown.

Objectives: This review aimed to investigate the effectiveness and safety of non-pharmacological therapies for the management of chronic pain in pwMS. Read More

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http://doi.wiley.com/10.1002/14651858.CD012622.pub2
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http://dx.doi.org/10.1002/14651858.CD012622.pub2DOI Listing
December 2018
11 Reads

The clinical utility of ambulatory EEG in childhood.

Seizure 2019 Jan 29;64:45-49. Epub 2018 Nov 29.

School of Medicine, College of Medical & Veterinary Life Sciences, University of Glasgow, United Kingdom; Paediatric Neurosciences Research Group & EEG Department, Royal Hospital for Children, Glasgow, United Kingdom. Electronic address:

Purpose: To evaluate the clinical utility of the ambulatory electroencephalogram (AEEG) in children.

Method: Data from 199 consecutive referrals for a paediatric AEEG were reviewed retrospectively. Information was gathered on various aspects of the referral process, the characteristics of the children referred and the reasons for referral. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183058
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http://dx.doi.org/10.1016/j.seizure.2018.11.020DOI Listing
January 2019
8 Reads

Prognostic evaluation of child patients with infectious encephalitis through AEEG and REEG.

Exp Ther Med 2018 Dec 19;16(6):5243-5247. Epub 2018 Oct 19.

Department of Internal Medicine, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

This study investigated prognostic evaluation of child patients with viral encephalitis through ambulatory electroencephalogram (AEEG) and regular electroencephalogram (REEG). A total of 94 child patients who were clinically diagnosed with viral encephalitis in Yantaishan Hospital of Yantai from May 2010 to July 2014, was examined with AEEG and REEG, respectively and randomly divided into AEEG group (n=47) and REEG group (n=47). The probabilities of detecting abnormal electroencephalographic activities with two examination methods were compared. Read More

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http://dx.doi.org/10.3892/etm.2018.6882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257196PMC
December 2018

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves.

Clin EEG Neurosci 2018 Nov 14:1550059418813020. Epub 2018 Nov 14.

1 University of South Florida, Tampa, FL, USA.

Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Read More

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http://dx.doi.org/10.1177/1550059418813020DOI Listing
November 2018
2 Reads

Optimal recording duration of ambulatory EEG (aEEG).

Epilepsy Res 2019 01 3;149:9-12. Epub 2018 Aug 3.

Adult Stanford Comprehensive Epilepsy Center, United States.

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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.025DOI Listing
January 2019
2 Reads

Transient epileptic and global amnesia: Real-life differential diagnosis.

Epilepsy Behav 2018 Nov 5;88:205-211. Epub 2018 Oct 5.

Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, University Campus Bio-Medico of Rome, via Álvaro del Portillo, 21, 00128 Rome, Italy. Electronic address:

Objective: Transient epileptic amnesia (TEA) is an underestimated condition in emergency clinical setting, where most of transient amnesic episodes tend to be classified as transient global amnesia (TGA). We designed this study to evaluate the actual frequency of TEA in a real-life scenario and to highlight the features that can help clinicians distinguishing it from TGA.

Methods: We retrospectively collected clinical data of 83 patients who accessed our emergency ward for an abrupt onset of amnesic disorder, initially interpreted as TGA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183021
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http://dx.doi.org/10.1016/j.yebeh.2018.07.015DOI Listing
November 2018
19 Reads

Cognitive tasks and human ambulatory electrocorticography using the RNS System.

J Neurosci Methods 2019 Jan 26;311:408-417. Epub 2018 Sep 26.

School of Graduate and Advanced Studies, Dartmouth College, Hanover, NH 03755, United States; Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, United States.

Background: Electrocorticography studies are typically conducted in patients undergoing video EEG monitoring, but these studies are subject to confounds such as the effects of pain, recent anesthesia, analgesics, drug changes, antibiotics, and implant effects.

New Method: Techniques were developed to obtain electrocorticographic (ECoG) data from freely moving subjects performing navigational tasks using the RNS System (NeuroPace, Inc., Mountain View, CA), a brain-responsive neurostimulation medical device used to treat focal onset epilepsy, and to align data from the RNS System with cognitive task events with high precision. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.09.026DOI Listing
January 2019
4 Reads

Home video telemetry in children: A comparison to inpatient video telemetry.

Seizure 2018 Oct 8;61:209-213. Epub 2018 Sep 8.

Sheffield Institute for Translational Neuroscience, University of Sheffield, 385A Glossop Road, Sheffield, S10 2HQ, UK; Department of Clinical Neurophysiology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. Electronic address:

Purpose: Home Video Telemetry (HVT) combines ambulatory EEG with simultaneous video recording. No previous reports have compared HVT and inpatient video telemetry (IVT) in a purely paediatric population. This study compares HVT and IVT in this group in terms of diagnostic efficacy, recording quality and acceptability to parents/carers. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.08.028DOI Listing
October 2018
3 Reads

Neuromonitoring in the ambulatory anesthesia setting: a pro-con discussion.

Curr Opin Anaesthesiol 2018 Dec;31(6):667-672

Department of Anesthesiology.

Purpose Of Review: Various neurologically focused monitoring modalities such as processed electroencephalography (pEEG), tissue/brain oxygenation monitors (SbO2), and even somatosensory evoked responses have been suggested as having the potential to improve the well tolerated and effective delivery of care in the setting of outpatient surgery. The present article will discuss the pros and cons of such monitors in this environment.

Recent Findings: There is a paucity of evidence from rigorous, well designed clinical trials demonstrating that the routine use of any neuromonitoring technique in an ambulatory surgery setting leads to meaningful cost savings or a reduction in morbidity or mortality. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000654DOI Listing
December 2018
13 Reads
1.979 Impact Factor

The impact of sleep characteristics and epilepsy variables on memory performance in patients with focal seizures.

Epilepsy Behav 2018 10 8;87:152-158. Epub 2018 Aug 8.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, Australia; ARC Centre of Excellence in Cognition and Its Disorders, Sydney Medical School, The University of Sydney, Sydney, Australia.

Disturbed sleep can negatively affect overnight memory retention as well as new learning the subsequent day. In healthy participants, positive associations between memory performance and sleep characteristics (e.g. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.034DOI Listing
October 2018
14 Reads

Automated Detection of Convulsive Seizures Using a Wearable Accelerometer Device.

IEEE Trans Biomed Eng 2018 Jun 11. Epub 2018 Jun 11.

Epileptic seizure detection requires specialized approaches such as video/electroencephalography monitoring. However, these approaches are restricted mainly to hospital setting and requires video/EEG analysis by experts, which makes these approaches resource- and labor-intensive. In contrast, we aim to develop a wireless remote monitoring system based on a single wrist-worn accelerometer device, which is sensitive to multiple types of convulsive seizures and is capable of detecting seizures with short duration. Read More

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http://dx.doi.org/10.1109/TBME.2018.2845865DOI Listing
June 2018
21 Reads
2.347 Impact Factor

Automated Detection of Convulsive Seizures Using a Single Wrist-Worn Accelerometer Device.

IEEE Trans Biomed Eng 2018 Jun 11. Epub 2018 Jun 11.

Epileptic seizure detection requires specialized approaches such as video/electroencephalography monitoring. However, these approaches are restricted mainly to hospital setting and requires video/EEG analysis by experts, which makes these approaches resource- and labor-intensive. In contrast, we aim to develop a wireless, remote monitoring system using a single wrist-worn accelerometer sensor, which is sensitive to multiple types of convulsive seizures and is capable of detecting seizures with short duration. Read More

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http://dx.doi.org/10.1109/TBME.2018.2845865DOI Listing
June 2018
22 Reads
2.347 Impact Factor

A Comparison of Two Nights of Ambulatory Sleep Testing in Arrhythmia Patients.

Sleep Disord 2018 3;2018:2394146. Epub 2018 Jun 3.

Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Introduction: Obstructive sleep apnea (OSA) is common and usually underdetected in patients with cardiac arrhythmia. Ambulatory sleep testing may provide an alternative method for detection of OSA under realistic conditions compared to in-laboratory polysomnography. We aimed to (1) determine the sleep architecture in arrhythmia patients; (2) detect differences in sleep parameters between patients with and without OSA; and (3) compare the results of two consecutive nights of unattended ambulatory sleep testing. Read More

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https://www.hindawi.com/journals/sd/2018/2394146/
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http://dx.doi.org/10.1155/2018/2394146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008611PMC
June 2018
19 Reads

Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study.

Ital J Pediatr 2018 Jun 15;44(1):70. Epub 2018 Jun 15.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, China.

Background: In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge.

Methods: Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). Read More

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http://dx.doi.org/10.1186/s13052-018-0507-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003147PMC
June 2018
12 Reads

Multiuser communication scheme based on binary phase-shift keying and chaos for telemedicine.

Comput Methods Programs Biomed 2018 Aug 17;162:165-175. Epub 2018 May 17.

Engineering, Architecture and Design Faculty, Autonomous University of Baja California (UABC), Ensenada, BC, Mexico. Electronic address:

Background And Objectives: Currently, telemedicine is levered upon the improvement in communication network technology such as Body Area Sensor Networks (BASN) to provided biomedicine solutions. Nevertheless, information security is an important issue since biomedical data is exchanged through insecure channels, which exposes private information that can be intercepted by malicious intruder. Therefore, secure communication protocols for multiuser networks in telemedicine applications are a big challenge. Read More

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http://dx.doi.org/10.1016/j.cmpb.2018.05.021DOI Listing
August 2018
2 Reads

Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation.

Epilepsy Behav 2018 08 8;85:7-9. Epub 2018 Jun 8.

University of California Irvine (UCI) Health, Department of Neurology, USA.

Background: The effect of direct brain responsive neurostimulation on the frequency of electrographic seizures in patients with medically refractory focal epilepsy has not been evaluated by chronic ambulatory electrocorticographic monitoring.

Methods: This was a retrospective study of 9 patients who underwent implantation of the responsive neurostimulator (RNS) system from 2015 to 2017 at the University of California, Irvine. Leads were placed at the ictal onset zone as determined by intracranial electroencephalography (EEG). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.05.008DOI Listing
August 2018
20 Reads
2.260 Impact Factor

Dynamics of corticospinal motor control during overground and treadmill walking in humans.

J Neurophysiol 2018 Sep 30;120(3):1017-1031. Epub 2018 May 30.

Movement Neuroscience Group, Institute of Health and Biomedical Innovation, Queensland University of Technology , Brisbane , Australia.

Increasing evidence suggests cortical involvement in the control of human gait. However, the nature of corticospinal interactions remains poorly understood. We performed time-frequency analysis of electrophysiological activity acquired during treadmill and overground walking in 22 healthy, young adults. Read More

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http://dx.doi.org/10.1152/jn.00613.2017DOI Listing
September 2018
17 Reads

Seizure detection: do current devices work? And when can they be useful?

Curr Neurol Neurosci Rep 2018 May 23;18(7):40. Epub 2018 May 23.

Epilepsy Center, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Purpose Of Review: The unpredictability and apparent randomness of epileptic seizures is one of the most vexing aspects of epilepsy. Methods or devices capable of detecting seizures may help prevent injury or even death and significantly improve quality of life. Here, we summarize and evaluate currently available, unimodal, or polymodal detection systems for epileptic seizures, mainly in the ambulatory setting. Read More

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http://link.springer.com/10.1007/s11910-018-0849-z
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http://dx.doi.org/10.1007/s11910-018-0849-zDOI Listing
May 2018
8 Reads

Human emotion classification based on multiple physiological signals by wearable system.

Technol Health Care 2018 ;26(S1):459-469

School of Electrical Engineering and Automaton, Harbin Institute of Technology, Harbin, Heilongjiang, China.

Background: Human emotion classification is traditionally achieved using multi-channel electroencephalogram (EEG) signal, which requires costly equipment and complex classification algorithms.

Objective: The experiments can be implemented in the laboratory environment equipped with high-performance computers for the online analysis; this will hinder the usability in practical applications.

Methods: Considering that other physiological signals are also associated with emotional changes, this paper proposes to use a wearable, wireless system to acquire a single-channel electroencephalogram signal, respiration, electrocardiogram (ECG) signal, and body postures to explore the relationship between these signals and the human emotions. Read More

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http://dx.doi.org/10.3233/THC-174747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004961PMC
November 2018
7 Reads

The prevalence of obstructive sleep apnea in patients with atrial fibrillation.

Clin Cardiol 2018 May 10;41(5):601-607. Epub 2018 May 10.

Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario.

Background: Obstructive sleep apnea (OSA) is a systemic disorder associated with significant cardiovascular complications. OSA may play a role in the initiation and worsening of atrial fibrillation (AF). This study aimed to determine the prevalence and clinical predictors of OSA in patients with AF. Read More

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http://dx.doi.org/10.1002/clc.22933DOI Listing
May 2018
5 Reads

Prevalence, Semiology, and Risk Factors of Epilepsy in Alzheimer's Disease: An Ambulatory EEG Study.

J Alzheimers Dis 2018 ;63(3):1045-1054

National Institute of Clinical Neurosciences, Hungary.

Background: Alzheimer's disease (AD) is the primary cause of cognitive decline. A growing body of evidence suggests that AD patients have a higher risk to develop epileptic seizures; however, results are contradictory due to different methodological approaches of previous studies.

Objective: We aimed to identify the prevalence, semiology, and risk factors of epilepsy in AD using long-term EEG. Read More

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http://dx.doi.org/10.3233/JAD-170925DOI Listing
January 2018
17 Reads

Diazepam for outpatient treatment of nonconvulsive status epilepticus in pediatric patients with Angelman syndrome.

Epilepsy Behav 2018 05 27;82:74-80. Epub 2018 Mar 27.

Department of Pediatric Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States; Angelman Syndrome Clinic, Massachusetts General Hospital, 175 Cambridge Street Suite 340, Boston, MA 02114, United States. Electronic address:

Nonconvulsive status epilepticus (NCSE) is present in multiple pediatric neurogenetic syndromes with epileptic encephalopathies. While intravenous (IV) medications are used inpatient for treatment of critical illness-related NCSE, there is no consensus on treatment of ambulatory NCSE. Up to 50% of patients with Angelman syndrome (AS) have NCSE with myoclonic or atypical absence status. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050173106
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http://dx.doi.org/10.1016/j.yebeh.2018.02.027DOI Listing
May 2018
17 Reads

Performance of an Ambulatory Dry-EEG Device for Auditory Closed-Loop Stimulation of Sleep Slow Oscillations in the Home Environment.

Front Hum Neurosci 2018 8;12:88. Epub 2018 Mar 8.

Rythm SAS, Paris, France.

Recent research has shown that auditory closed-loop stimulation can enhance sleep slow oscillations (SO) to improve N3 sleep quality and cognition. Previous studies have been conducted in lab environments. The present study aimed to validate and assess the performance of a novel ambulatory wireless dry-EEG device (WDD), for auditory closed-loop stimulation of SO during N3 sleep at home. Read More

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http://journal.frontiersin.org/article/10.3389/fnhum.2018.00
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http://dx.doi.org/10.3389/fnhum.2018.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853451PMC
March 2018
34 Reads

Surrogate-Based Artifact Removal From Single-Channel EEG.

IEEE Trans Neural Syst Rehabil Eng 2018 03;26(3):540-550

Objective: the recent emergence and success of electroencephalography (EEG) in low-cost portable devices, has opened the door to a new generation of applications processing a small number of EEG channels for health monitoring and brain-computer interfacing. These recordings are, however, contaminated by many sources of noise degrading the signals of interest, thus compromising the interpretation of the underlying brain state. In this paper, we propose a new data-driven algorithm to effectively remove ocular and muscular artifacts from single-channel EEG: the surrogate-based artifact removal (SuBAR). Read More

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http://dx.doi.org/10.1109/TNSRE.2018.2794184DOI Listing
March 2018
4 Reads

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats.

Anesthesiology 2018 May;128(5):992-1003

From the Department of Neuroscience (S.T.) and the Center for Neuroscience of Pain (N.S., M.S.), Jikei University School of Medicine, Tokyo, Japan; Department of Critical Care and Anesthesia, National Center for Child Health and Development, Tokyo, Japan (S.T.); Department of Palliative Medicine, Jikei University Hospital, Tokyo, Japan (N.S., M.S.); Department of Anesthesiology, Teikyo University Chiba Medical Center, Ichihara, Japan (Y.T); and the International Institute for Integrative Sleep Medicine (World Premier International Research Center Initiative), University of Tsukuba, Tsukuba, Japan (H.N., T.S., M.Y.).

Background: Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role in maintaining wakefulness. This study aimed to explore the potential of a nonpeptide orexin receptor agonist to alleviate morphine-induced sedative effects. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002161DOI Listing
May 2018
16 Reads

Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies.

Front Neurol 2018 19;9:36. Epub 2018 Feb 19.

Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, VIC, Australia.

We sought to investigate (1) the characteristics of epileptiform discharge (ED) duration and interdischarge interval (IDI) and (2) the influence of vigilance state on the ED duration and IDI in genetic generalized epilepsy (GGE). In a cohort of patients diagnosed with GGE, 24-h ambulatory EEG recordings were performed prospectively. We then tabulated durations, IDI, and vigilance state in relation to all EDs captured on EEGs. Read More

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http://dx.doi.org/10.3389/fneur.2018.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827541PMC
February 2018
4 Reads

Diagnostic challenges in epilepsy: seizure under-reporting and seizure detection.

Lancet Neurol 2018 03;17(3):279-288

Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany. Electronic address:

Epileptic seizures vary greatly in clinical phenomenology and can markedly affect the patient's quality of life. As therapeutic interventions focus on reduction or elimination of seizures, the accurate documentation of seizure occurrence is essential. However, patient self-evaluation compared with objective evaluation by video-electroencephalography (EEG) monitoring or long-term ambulatory EEG revealed that patients document fewer than 50% of their seizures, on average, and that documentation accuracy varies significantly over time. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30038-3DOI Listing
March 2018
2 Reads

Seizure clustering during presurgical electroencephalographic monitoring in children.

Epilepsy Behav 2018 03 3;80:291-295. Epub 2018 Feb 3.

Division of Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

Background: Presurgical evaluation with antiseizure medication tapering in patients with refractory epilepsy places them at risk for seizure clustering or prolonged seizures. We looked at the occurrence of seizure clustering (3 or more seizures within 24h) and prolonged seizures and the factors that influence seizure clustering and affect length of stay (LOS) in pediatric patients during presurgical monitoring.

Methods: We retrospectively reviewed the medical records of all consecutive admissions to the epilepsy monitoring unit (EMU) and included patients undergoing noninvasive presurgical evaluation. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.01.013DOI Listing
March 2018
7 Reads

Are the days of counting seizures numbered?

Curr Opin Neurol 2018 04;31(2):162-168

Department of Medicine, St Vincent's Hospital Melbourne.

Purpose Of Review: The estimation of seizure frequency is a cornerstone of clinical management of epilepsy and the evaluation of new therapies. Current estimation approaches are significantly limited by several factors. Comparing patient diaries and objective estimates (through both inpatient video-EEG monitoring of and long-term ambulatory EEG studies) reveal that patients document seizures inaccurately. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000533DOI Listing
April 2018
5 Reads

Effects of bedtime periocular and posterior cervical cutaneous warming on sleep status in adult male subjects: a preliminary study.

Sleep Biol Rhythms 2018 14;16(1):77-84. Epub 2017 Oct 14.

2Department of Psychiatry, Nihon University School of Medicine, Oyaguchi Kamicho, Itabashi-ku, Tokyo, 173-8610 Japan.

Appropriate warming of the periocular or posterior cervical skin has been reported to induce autonomic or mental relaxation in humans. To clarify the effects of cutaneous warming on human sleep, eight male subjects with mild sleep difficulties were asked to try three experimental conditions at home, each lasting for 5 days, in a cross-over manner: warming of the periocular skin with a warming device for 10 min before habitual bedtime, warming of the posterior cervical skin with a warming device for 30 min before habitual bedtime, and no treatment as a control. The warming device had a heat- and steam-generating sheet that allowed warming of the skin to 40 °C through a chemical reaction with iron. Read More

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http://link.springer.com/10.1007/s41105-017-0129-3
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http://dx.doi.org/10.1007/s41105-017-0129-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754422PMC
October 2017
13 Reads

Consistency of Long-Term Subdural Electrocorticography in Humans.

IEEE Trans Biomed Eng 2018 02;65(2):344-352

Objective: Subdural electrocorticography (ECoG) can provide a robust control signal for a brain-computer interface (BCI). However, the long-term recording properties of ECoG are poorly understood as most ECoG studies in the BCI field have only used signals recorded for less than 28 days. We assessed human ECoG recordings over durations of many months to investigate changes to recording quality that occur with long-term implantation. Read More

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http://ieeexplore.ieee.org/document/8090884/
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http://dx.doi.org/10.1109/TBME.2017.2768442DOI Listing
February 2018
17 Reads

Categorisation of Mobile EEG: A Researcher's Perspective.

Biomed Res Int 2017 4;2017:5496196. Epub 2017 Dec 4.

Hull York Medical School, University of Hull, Hull HU6 7RX, UK.

Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term "mobile EEG," although commonly used to describe many of these undertakings, is ambiguous, since it attempts to encompass a wide range of EEG device mobility, participant mobility, and system specifications used across investigations. To provide quantitative parameters for "mobile EEG," we developed a Categorisation of Mobile EEG (CoME) scheme based upon scoring of device mobility (, from 0, off-body, to 5, head-mounted with no additional equipment), participant mobility (, from 0, static, to 5, unconstrained running), system specification (, from 4, lowest, to 20, highest), and number of channels () used. Read More

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http://dx.doi.org/10.1155/2017/5496196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733835PMC
August 2018
2 Reads

Improving the anesthetic process by a fuzzy rule based medical decision system.

Artif Intell Med 2018 01 5;84:159-170. Epub 2018 Jan 5.

Universidad de La Laguna, La Laguna, Tenerife, Spain.

Objective: The main objective of this research is the design and implementation of a new fuzzy logic tool for automatic drug delivery in patients undergoing general anesthesia. The aim is to adjust the drug dose to the real patient needs using heuristic knowledge provided by clinicians. A two-level computer decision system is proposed. Read More

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http://dx.doi.org/10.1016/j.artmed.2017.12.005DOI Listing
January 2018
9 Reads

Local changes in computational non-rapid eye movement sleep depth in infants.

Clin Neurophysiol 2017 Oct 16;129(2):448-454. Epub 2017 Oct 16.

Department of Clinical Neurophysiology, Tampere University Hospital, Medical Imaging Centre and Hospital Pharmacy, Pirkanmaa Hospital District, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Objective: Deep NREM sleep and its hallmark EEG phenomenon slow wave activity (SWA) are under homeostatic control in adults. SWA is also locally regulated as it increases in the brain areas that have been used intensively. Moreover, in children, SWA is a marker of cortical maturation. Read More

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http://dx.doi.org/10.1016/j.clinph.2017.09.116DOI Listing
October 2017
16 Reads

Seizure Forecasting from Idea to Reality. Outcomes of the My Seizure Gauge Epilepsy Innovation Institute Workshop.

eNeuro 2017 Nov-Dec;4(6). Epub 2017 Dec 27.

Research and New Therapies, Epilepsy Foundation of America, Landover, MD 20784.

The Epilepsy Innovation Institute (Ei) is a new research program of the Epilepsy Foundation designed to be an innovation incubator for epilepsy. Ei research areas are selected based on community surveys that ask people impacted by epilepsy what they would like researchers to focus on. In their 2016 survey, unpredictability was selected as a top issue regardless of seizure frequency or severity. Read More

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http://dx.doi.org/10.1523/ENEURO.0349-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744646PMC
December 2018
9 Reads

Evaluation of the "non-epileptic" patient in a tertiary center epilepsy clinic.

Epilepsy Behav 2018 02 19;79:100-105. Epub 2017 Dec 19.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address:

Purpose: The epilepsy clinic at the Montreal Neurological Institute receives a high volume of referrals. Despite most patients assessed in the clinic eventually being diagnosed with epilepsy, other disorders causing alteration of consciousness or paroxystic symptoms that could be misdiagnosed as seizures are seen frequently. The incidence and clinical characteristics of such patients have not yet been determined. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.11.001DOI Listing
February 2018
10 Reads

Changes in the electrocorticogram after implantation of intracranial electrodes in humans: The implant effect.

Clin Neurophysiol 2018 03 14;129(3):676-686. Epub 2017 Nov 14.

NeuroPace, Inc., Mountain View, CA 94043, USA; Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA 94305, USA.

Objective: Subacute and long-term electrocorticographic (ECoG) changes in ambulatory patients with depth and cortical strip electrodes were evaluated in order to determine the length of the implant effect.

Methods: ECoG records were assessed in patients with medically intractable epilepsy who had depth and/or strip leads implanted in order to be treated with brain-responsive stimulation. Changes in total spectral power, band-limited spectral power, and spike rate were assessed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13882457173114
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http://dx.doi.org/10.1016/j.clinph.2017.10.036DOI Listing
March 2018
9 Reads

Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement.

Curr Biol 2017 Dec 30;27(24):3743-3751.e3. Epub 2017 Nov 30.

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

The theta rhythm-a slow (6-12 Hz) oscillatory component of the local field potential-plays a critical role in spatial navigation and memory by coordinating the activity of neuronal ensembles within the medial temporal lobe (MTL). Although theta has been extensively studied in freely moving rodents, its presence in humans has been elusive and primarily investigated in stationary subjects. Here we used a unique clinical opportunity to examine theta within the human MTL during untethered, real-world ambulatory movement. Read More

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http://dx.doi.org/10.1016/j.cub.2017.10.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937848PMC
December 2017
6 Reads

De novo absence status epilepticus of late onset (DNASLO) precipitated by oral treatment with cefuroxime: description of an ambulatory case.

Epileptic Disord 2018 Feb;20(1):73-76

Biomedical Research Institute (IDIVAL), Santander, Department of Intensive Medicine, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain.

We describe the case of an elderly woman with an episode of ambulatory de novo absence status epilepticus of late onset (DNASLO) after oral treatment with cefuroxime. A high level of suspicion of DNASLO in cases of unexplained confusion in adults or elderly subjects taking cephalosporins is essential to prompt an emergency EEG and, in turn, rapidly achieve an appropriate diagnosis and enable optimal treatment. Read More

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http://dx.doi.org/10.1684/epd.2017.0938DOI Listing
February 2018
8 Reads

Indications and methodology for video-electroencephalographic studies in the epilepsy monitoring unit.

Epilepsia 2018 01 10;59(1):27-36. Epub 2017 Nov 10.

University of Arizona, Tucson, AZ, USA.

Although the epilepsy and neurology communities have position papers on a number of topics pertaining to epilepsy diagnosis and management, no current paper exists for the rationale and appropriate indications for epilepsy monitoring unit (EMU) evaluation. General neurologists, hospital administrators, and insurers also have yet to fully understand the role this type of testing has in the diagnosis and management of individuals with paroxysmal neurologic symptoms. This review outlines the indications for long-term video-electroencephalography (VEEG) for typical elective admissions to a specialized inpatient setting. Read More

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http://doi.wiley.com/10.1111/epi.13938
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http://dx.doi.org/10.1111/epi.13938DOI Listing
January 2018
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Detection of generalized tonic-clonic seizures using short length accelerometry signal.

Conf Proc IEEE Eng Med Biol Soc 2017 07;2017:4566-4569

Epileptic seizures are characterized by the excessive and abrupt electrical discharge in the brain. This asynchronous firing of neurons causes unprovoked convulsions which can be a cause of sudden unexpected death in epilepsy (SUDEP). Remote monitoring of epileptic patients can help prevent SUDEP. Read More

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http://dx.doi.org/10.1109/EMBC.2017.8037872DOI Listing
July 2017
5 Reads

Impairment of heart rhythm complexity in patients with drug-resistant epilepsy: An assessment with multiscale entropy analysis.

Epilepsy Res 2017 12 5;138:11-17. Epub 2017 Oct 5.

National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, 100084 Beijing, China; Man-Machine-Environment Engineering Institute, School of Aerospace Engineering, Tsinghua University, 100084 Beijing, China; Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, 518055, Shenzhen, China; Center of Epilepsy, Beijing Institute for Brain Disorders, 100069, Beijing, China. Electronic address:

Objective: Epilepsy and seizures can have dramatic effects on the cardiac function. The aim of this study was to investigate the heart rhythm complexity in patients with drug-resistant epilepsy (DRE).

Methods: Ambulatory 24-h electrocardiograms (ECG) from 70 DRE patients and 50 healthy control subjects were analyzed using conventional heart rate variability (HRV) and multiscale entropy (MSE) methods The variation of complexity indices (CI), which was calculated from MSE profile, was determined. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2017.10.002DOI Listing
December 2017
47 Reads

myBrain: a novel EEG embedded system for epilepsy monitoring.

J Med Eng Technol 2017 Oct 10;41(7):564-585. Epub 2017 Oct 10.

e School of Health Sciences , University of Minho , Braga , Portugal.

The World Health Organisation has pointed that a successful health care delivery, requires effective medical devices as tools for prevention, diagnosis, treatment and rehabilitation. Several studies have concluded that longer monitoring periods and outpatient settings might increase diagnosis accuracy and success rate of treatment selection. The long-term monitoring of epileptic patients through electroencephalography (EEG) has been considered a powerful tool to improve the diagnosis, disease classification, and treatment of patients with such condition. Read More

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http://dx.doi.org/10.1080/03091902.2017.1382585DOI Listing
October 2017
16 Reads