10,784 results match your criteria Am. J. Med. Sci.[Journal]


Thrombocytopenia as a Prognostic Marker for Systemic Lupus Erythematosus: A Systematic Review and Meta-analysis.

Am J Med Sci 2019 Mar 11. Epub 2019 Mar 11.

Department of Rheumatology and Immunology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. Electronic address:

Background: Systemic lupus erythematosus (SLE) patients often exhibit hematological abnormalities, but the role of thrombocytopenia on the prognosis of SLE shows inconsistent results. The purpose of this meta-analysis was to confirm the impact of thrombocytopenia on mortality and end organ damage in patients with SLE.

Materials And Methods: Three electronic databases, PubMed, Embase and Cochrane library were systematically searched to identify the eligible studies from inception to November 2017 in order to evaluate the impact of thrombocytopenia on the prognosis of patients with SLE. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.03.002DOI Listing

Cerebral Venous Thrombosis.

Am J Med Sci 2019 Mar 9. Epub 2019 Mar 9.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University, Tochigi, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00029629193009
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http://dx.doi.org/10.1016/j.amjms.2019.03.001DOI Listing
March 2019
1 Read

An Unusual Cause of Dysphagia in an Elderly Woman: Dysphagia Megalatriensis.

Am J Med Sci 2019 Feb 23. Epub 2019 Feb 23.

Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan; General Education Center, Chienkuo Technology University, Changhua, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.02.018DOI Listing
February 2019
1 Read

Symptomatic Hyperglycemia in a Patient with Dialysis Ascites.

Am J Med Sci 2019 Feb 27. Epub 2019 Feb 27.

Division of Nephrology, Department of Medicine; Research Service, Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico. Electronic address:

An anuric woman with ascites rapidly developed extreme hyperglycemia and seizures after hemodialysis. During development of hyperglycemia, the decrease in serum sodium concentration (Δ[Na]) was nearly twice the value predicted by a formula accounting for the degree of hyperglycemia and the intracellular-to-extracellular volume ratio. The prediction assumed that ascitic fluid is part of the extracellular volume. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.016DOI Listing
February 2019
1 Read

Miliary Nodules in a Young Patient With AIDS: Not Always Tuberculosis.

Am J Med Sci 2019 Feb 23. Epub 2019 Feb 23.

AMITA Health Saint Joseph Hospital, Department of Internal Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.amjms.2019.02.019DOI Listing
February 2019
1 Read
1.515 Impact Factor

Mesotherapy-Associated Cutaneous Infection.

Am J Med Sci 2019 Feb 22. Epub 2019 Feb 22.

Infectious Diseases Section, Internal Medicine Department, University of Antioquia School of Medicine, Medellín, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.02.015DOI Listing
February 2019

Treating the Bone to Protect the Heart: Potential Newer Mechanisms and Targets.

Am J Med Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.02.001DOI Listing
February 2019

Bigger is Betterin ARDS.

Am J Med Sci 2019 Feb 21. Epub 2019 Feb 21.

Division of Pulmonary, Critical Care, Sleep and Allergy, University of Chicago at Illinois, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.02.017DOI Listing
February 2019

Di-(2-Ethylhexyl) Phthalate Promotes Release of Tissue Factor-Bearing Microparticles From Macrophages via the TGFβ1/Smad/PAI-1 Signaling Pathway.

Am J Med Sci 2019 Feb 14. Epub 2019 Feb 14.

Graduate School of Medical Science, Kumamoto Health Science University, Kumamoto, Japan. Electronic address:

Background: Plasminogen activator inhibitor type 1 promotes formation of endothelial microparticles with procoagulant activity. However, it remains unclear whether di-(2-ethylhexyl) phthalate, a peroxisome proliferator-activated receptor α agonist, influences microparticle formation.

Materials And Methods: The effect of di-(2-ethylhexyl) phthalate on release of tissue factor-bearing microparticles was investigated using human M1 macrophages. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.012DOI Listing
February 2019

Subglottic Stenosis in Granulomatosis With Polyangiitis.

Am J Med Sci 2019 Apr 12;357(4):e13-e14. Epub 2019 Jan 12.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

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http://dx.doi.org/10.1016/j.amjms.2019.01.005DOI Listing
April 2019
2 Reads

Likely Consequences of Medicare for All.

Am J Med Sci 2019 Apr 16;357(4):352-353. Epub 2019 Jan 16.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas; Free Market Institute, Texas Tech University, Lubbock, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.01.006DOI Listing

Farnesyl Pyrophosphate Synthase Blocker Ibandronate Reduces Thoracic Aortic Fibrosis in Diabetic Rats.

Am J Med Sci 2019 Apr 31;357(4):323-332. Epub 2019 Jan 31.

Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang, China. Electronic address:

Background: This study assessed the effect of ibandronate (IBN), a farnesyl pyrophosphate synthase (FPPS) inhibitor, on vascular remodeling in diabetic rats.

Methods: A rat model of diabetes was induced by a high-fat and high-sugar diet combined with a small dose of streptozotocin. The diabetic rats received 5 µg/kg of ibandronate solution or normal saline subcutaneously every morning for 16 weeks. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.014DOI Listing
April 2019
1 Read

Primary Pulmonary Lymphoma: A Retrospective Analysis of 27 Cases in a Single Tertiary Hospital.

Am J Med Sci 2019 Apr 22;357(4):316-322. Epub 2019 Jan 22.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China. Electronic address:

Background: The objective of this study was to improve the understanding of primary pulmonary lymphoma (PPL) for clinicians.

Methods: We enrolled 27 patients diagnosed with PPL in the First Affiliated Hospital of Soochow University from January 2000 to December 2016. The clinical manifestations, imaging findings, pathologic features, treatments and prognosis of the patients were collected. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.009DOI Listing
April 2019
3 Reads

Soluble Vascular Cell Adhesion Molecule-1 Is Associated With Disease Activity in Adult-Onset Minimal Change Disease.

Am J Med Sci 2019 Apr 2;357(4):311-315. Epub 2019 Feb 2.

Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. Electronic address:

Background: Cell adhesion molecules have been documented to be elevated in numerous immune inflammatory diseases. Minimal change disease (MCD) is an immune disorder. This study aimed to evaluate whether levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) reflect disease activity in adult-onset MCD. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.017DOI Listing
April 2019
1 Read

CXCR4 and CCR7 Expression in Primary Nodal Diffuse Large B-Cell Lymphoma-A Clinical and Immunohistochemical Study.

Am J Med Sci 2019 Apr 21;357(4):302-310. Epub 2019 Jan 21.

Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China. Electronic address:

Background: A few studies have evaluated the expression of chemokine receptors CXCR4 and CCR7 in diffuse large B-cell lymphoma (DLBCL); however, the association between CXCR4 and CCR7 with bone marrow (BM) involvement and their synergistic effect on prognosis is still unclear. Our study investigated this aspect.

Methods: Specimens were obtained from 61 primary nodal DLBCL patients and 100 reactive proliferative lymphadenitis patients. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.008DOI Listing
April 2019
1 Read

Impact of Cirrhosis on Pneumonia-Related Outcomes in Hospitalized Older Veterans.

Am J Med Sci 2019 Apr 11;357(4):296-301. Epub 2019 Jan 11.

UConn Health, University of Connecticut School of Medicine, Farmington, Connecticut; VA North Texas Health Care System, Dallas, Texas. Electronic address:

Background: Prior research has demonstrated high mortality rates in patients with cirrhosis who contract bacterial infections. The purpose of our study was to explore clinical outcomes such as 90-day mortality, rehospitalization, and intensive care unit (ICU) admission in older veterans with pneumonia and cirrhosis.

Methods: We conducted a retrospective cohort study of hospitalized patients with community-acquired pneumonia at any Departments of Veterans Affairs (VA) hospital over a 10-year period. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.004DOI Listing
April 2019
4 Reads

Transmission Electron Microscopy in Severe Pneumonia: Back to the Future?

Am J Med Sci 2019 Apr 11;357(4):271-272. Epub 2019 Jan 11.

Division of Pulmonary, Department of Medicine, Critical Care and Sleep Disorders Medicine, and; Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, Kentucky.

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http://dx.doi.org/10.1016/j.amjms.2019.01.003DOI Listing
April 2019
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Research in Pulmonary Fibrosis Across Species: Unleashing Discovery Through Comparative Biology.

Am J Med Sci 2019 Feb 11. Epub 2019 Feb 11.

Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.02.005DOI Listing
February 2019

Metabolic Reprogramming as a Driver of Fibroblast Activation in Pulmonary Fibrosis.

Am J Med Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Center for Translational Research and Division of Pulmonary, Allergy and Critical Care Medicine, and; Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:

Pulmonary fibrosis refers to a heterogeneous group of disorders that scar the lung, most often irreversibly. To date, there are limited effective treatments for these conditions, despite decades of research in this area of investigation. In pulmonary fibrosis, the principle cell responsible for producing the vast majority of scar tissue is the fibroblast, making these cells ideally suited for drug targeting. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.003DOI Listing
February 2019

The Mayo Clinic Experience With Psychogenic Purpura (Gardner-Diamond Syndrome).

Am J Med Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota; Division of Hematopathology and Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: The objective of this study was to describe presentation, natural history, management and long-term outcomes of patients with psychogenic purpura (PP), also known as Gardner-Diamond Syndrome.

Methods: In this retrospective study, records of patients with a diagnosis of PP seen at Mayo Clinic, Rochester from 1976 to 2016 were reviewed. Available literature regarding PP was also comparatively reviewed. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.002DOI Listing
February 2019
1 Read

Torsion of the Wandering Spleen.

Am J Med Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Pathology, Kanuni Training and Research Hospital, Trabzon, Turkey.

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http://dx.doi.org/10.1016/j.amjms.2019.01.016DOI Listing
February 2019

Amebic Colitis.

Am J Med Sci 2019 Jan 19. Epub 2019 Jan 19.

Division of Gastroenterology and Hepatology and.

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http://dx.doi.org/10.1016/j.amjms.2019.01.007DOI Listing
January 2019

The Rediscovery of the DNA Molecule in Liquid Biopsies in Cancer.

Am J Med Sci 2019 Jan 30. Epub 2019 Jan 30.

Laboratório de Análises Clínicas, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.amjms.2019.01.012DOI Listing
January 2019
5 Reads

Between a Clot and a Scarred Place.

Am J Med Sci 2019 Jan 22. Epub 2019 Jan 22.

Hospitalist Division, Greater Los Angeles VA Medical Center, UCLA David Geffen School of Medicine, Los Angeles, California. Electronic address:

Immobilized orthopedic trauma patients face an elevated risk of venous thromboembolism (VTE). We present a case in which a patient undergoing staged repair of traumatic orthopedic injuries developed deep venous thrombosis (DVT) during hospitalization, prior to repair of a lower extremity injury for which delay in operation might result in poor functional outcome. We provide an overview of recommendations regarding pharmacologic prophylaxis of VTE in orthopedic patients. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.011DOI Listing
January 2019
4 Reads

The Birth of Angiotensin: An International Compromise.

Am J Med Sci 2019 Mar 4;357(3):179-183. Epub 2018 Sep 4.

State University of New York, Upstate Medical University, Syracuse, New York.

Irvine Page in the United States and Eduardo Braun-Menéndez in Argentina led teams of investigators that studied the role of the kidney in blood pressure regulation. Contemporaneously in 1939, each team using different methods discovered and described a new substance now known as angiotensin. At the time of discovery, Page called it "angiotonin" and Braun-Menéndez called it "hipertensina," anglicized to "hypertensin. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.08.017DOI Listing

Obestatin Downregulating Aquaporin 2 Plasma Membrane Distribution Through a Short-Term Regulatory Effect.

Am J Med Sci 2019 Mar 27;357(3):247-254. Epub 2018 Dec 27.

Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background: Previous studies have found that obestatin significantly inhibited water drinking and reduced the arginine vasopressin levels in the brain to decrease renal water reabsorption. However, obestatin is unable to cross the blood-brain barrier. Its effect on the body's kidney water metabolism in peripheral remains unknown. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.010DOI Listing

The Prognostic Role of Peripheral Lymphocyte Subsets in Patients With Acute Pancreatitis.

Am J Med Sci 2019 Mar 21;357(3):242-246. Epub 2018 Dec 21.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: The prognostic role of peripheral lymphocyte subsets in early stage of acute pancreatitis (AP) is unknown.

Methods: After enrollment, blood samples were collected in the first 24 hours of the onset of AP in 164 patients. The lymphocyte count and the percentage of CD3, CD3CD4, CD3CD8, CD3CD19and CD3CD (16 + 56) cells were assessed. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.008DOI Listing

Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Artery Stenosis.

Am J Med Sci 2019 Mar 21;357(3):230-241. Epub 2018 Dec 21.

Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address:

Background: The present study performed a meta-analysis of randomized and prospective trials to compare the outcomes of percutaneous coronary intervention (PCI) with stents versus coronary artery bypass graft surgery (CABG) for unprotected left main coronary artery (UPLM) stenosis.

Methods: The Cochrane Library, PubMed and EMBASE databases were systematically searched until July 2017. The Newcastle-Ottawa scale was used for quality assessment. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.007DOI Listing
March 2019
1.515 Impact Factor

Role of Vitamin D and Its Analogues in Diabetic Nephropathy: A Meta-analysis.

Am J Med Sci 2019 Mar 13;357(3):223-229. Epub 2018 Dec 13.

Department of Medicine, St. Vincent's Medical Center, Bridgeport, Connecticut; The Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, Connecticut.

Background: Diabetic nephropathy remains one of the most common causes of chronic kidney disease in the United States and is associated with significant morbidity and mortality. Recently, there have been emerging data highlighting the role of vitamin D and its analogue in chronic kidney disease especially diabetic nephropathy independent of its effect on bone metabolism.

Methods: This study aimed to evaluate effect of supplementing vitamin D and its analogues on halting or slowing progression of diabetic nephropathy. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.005DOI Listing

High Visceral Adipose Tissue to Subcutaneous Adipose Tissue Ratio as a Predictor of Mortality in Acute Respiratory Distress Syndrome.

Am J Med Sci 2019 Mar 29;357(3):213-222. Epub 2018 Nov 29.

Department of Respiratory and Critical Care.

Background: We aimed to further determine the relationship between the areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and the ratio of VAT to SAT (VAT/SAT) with the outcomes of acute respiratory distress syndrome (ARDS) patients.

Methods: A retrospective study was performed on patients with ARDS in 7 intensive care units (ICU) of West China Hospital, Sichuan University.

Results: A total of 169 patients were included in the analysis. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.015DOI Listing

Several Routes to the Same Destination: Inhibition of Phagosome-Lysosome Fusion by Mycobacterium tuberculosis.

Am J Med Sci 2019 Mar 8;357(3):184-194. Epub 2018 Dec 8.

Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico. Electronic address:

Phagocytosis is necessary for antigen degradation and presentation, the activation of the adaptive immune response and the elimination of pathogenic micro-organisms. The phagosomal vacuole formed during phagocytosis requires a process of maturation that involves fusion with lysosomes, a decrease in luminal pH and the activation of the enzymes that eventually will destroy phagocytized micro-organisms. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.003DOI Listing
March 2019
1.515 Impact Factor

Impact of Delayed Therapy in Serious Bacterial Infections: Role of Technology and the Clinician at the Bedside.

Am J Med Sci 2019 Mar 9;357(3):177-178. Epub 2019 Jan 9.

Emeritus Professor of Medicine, Wayne State University, Detroit, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.01.001DOI Listing

Goya's Lost Hearing: A Twenty-First Century Perspective on Its Cause, Effects and Possible Treatment.

Am J Med Sci 2019 Apr 24;357(4):275-279. Epub 2018 Dec 24.

Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland. Electronic address:

Francisco Goya produced over 1,800 works during his long career, which earned him a reputation as one of the greatest artists of modern times. When he was 47, he developed a mysterious illness that destroyed his hearing, and for the next 35 years left him "deaf as a stump." Of the diagnoses proposed to date, Susac syndrome is the one most consistent with what little we do know of the character of that illness. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.009DOI Listing
April 2019
1 Read

Angiogenesis Process in Osteosarcoma: An Updated Perspective of Pathophysiology and Therapeutics.

Am J Med Sci 2019 Apr 13;357(4):280-288. Epub 2018 Dec 13.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

In this review, we discuss the pathologic mechanism of the angiogenesis process in osteosarcoma (OS) and the therapeutic use of angiogenesis inhibitors in OS treatment. The activation of endothelial cells by angiogenic factors leads to the production of proteolytic enzymes, which degrade the extracellular matrix. The degradation of the underlying basement membrane enables endothelial cells to proliferate and migrate to the surrounding tissue to form new vessels. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.004DOI Listing
April 2019
1 Read
1.515 Impact Factor

Orchestrating Metabolic Flexibility: PGC-1α and Clinical Heart Failure.

Authors:
Jacob Joseph

Am J Med Sci 2019 Apr 11;357(4):273-274. Epub 2019 Jan 11.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2019.01.002DOI Listing

Severe Lytic Bone Lesions in Multiple Myeloma.

Am J Med Sci 2019 Apr 18;357(4):e11-e12. Epub 2018 Dec 18.

SUNY Downstate Medical Center, Brooklyn, New York. Electronic address:

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http://dx.doi.org/10.1016/j.amjms.2018.12.006DOI Listing

Sinonasal and Laryngeal Sarcoidosis-An Uncommon Presentation and Management Challenge.

Am J Med Sci 2019 Feb 22;357(2):93-102. Epub 2018 Nov 22.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas.

Sarcoidosis is a chronic inflammatory disease of uncertain etiology characterized by the formation of noncaseating granulomas. The thorax is involved in 95% of cases, but any organ can be involved. Sinonasal or laryngeal involvement is uncommon and can be difficult to diagnose. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.007DOI Listing
February 2019
7 Reads

In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats.

Am J Med Sci 2019 Feb 24;357(2):151-159. Epub 2018 Nov 24.

Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts. Electronic address:

Background: Myocardial fibrosis is a major pathophysiologic substrate of heart failure with preserved ejection fraction. Vasopressin is an important therapeutic target in heart failure with preserved ejection fraction since it can modulate fluid balance, and based on a few studies, myocardial matrix deposition. Hence we examined the role of vasopressin antagonism in modulating myocardial matrix metabolism in vivo and in vitro. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.010DOI Listing
February 2019
2 Reads

Managing Implantable Cardioverter-Defibrillators at End-of-Life: Practical Challenges and Care Considerations.

Am J Med Sci 2019 Feb 29;357(2):143-150. Epub 2018 Nov 29.

Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Implantable cardioverter-defibrillators (ICDs) monitor for and terminate malignant arrhythmias. Given their potential as a life-saving therapy, an increasing number of people receive an ICD every year, and a growing number are currently living with ICDs. However, cardiopulmonary arrest serves as the final common pathway of natural death, and the appropriate management of an ICD near the end-of-life is crucial to ensure that a patient's death is not marked by further suffering due to ICD shocks. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.016DOI Listing
February 2019
2 Reads

Long Noncoding RNA Antisense Noncoding RNA in the INK4 Locus Correlates With Risk, Severity, Inflammation and Infliximab Efficacy in Crohn's Disease.

Am J Med Sci 2019 Feb 22;357(2):134-142. Epub 2018 Nov 22.

Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of TCM, Zhejiang International Exchange Center of Clinical TCM, Hangzhou, China. Electronic address:

Background: The aim of this study was to investigate the association of intestinal mucosa long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) expression with disease risk, activity and inflammatory cytokines levels of Crohn's disease (CD).

Methods: Forty-two patients with active CD (A-CD), 59 patients with CD in remission (R-CD) and 67 controls were consecutively recruited. Intestinal mucosa samples were collected from all participants at baseline and from A-CD patients at 3-months after infliximab treatment. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.10.016DOI Listing
February 2019
4 Reads

Epidemiology of Sarcopenia and Factors Associated With It Among Community-Dwelling Older Adults in Taiwan.

Am J Med Sci 2019 Feb 22;357(2):124-133. Epub 2018 Nov 22.

Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; Department of Geriatric Medicine, National Yang Ming University, School of Medicine, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Sarcopenia is a well-recognized geriatric syndrome. We sought to determine the prevalence of sarcopenia and factors associated with it among community-dwelling older adults in Taiwan.

Methods: A cross-sectional study was conducted in Yuanshan Township, Yilan County, Taiwan. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.008DOI Listing
February 2019
2 Reads

Body Adiposity Index and Body Roundness Index in Identifying Insulin Resistance Among Adults Without Diabetes.

Am J Med Sci 2019 Feb 22;357(2):116-123. Epub 2018 Nov 22.

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Background: Body adiposity index (BAI) and body roundness index (BRI), initially developed to assess obesity, were evaluated here to detect insulin resistance in comparison with traditional anthropometric indices of body mass index (BMI), waist circumference (WC), weight-to-height ratio (WHtR), visceral adiposity index (VAI) and abdominal volume index (AVI).

Methods: In this cross-sectional study, 570 Chinese individuals without diabetes were evaluated.

Results: The Spearman rank test showed that insulin resistance correlated most strongly with WC and AVI in men and BMI in women, and most weakly with BAI in men and VAI in women. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.006DOI Listing
February 2019
1 Read

Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.

Am J Med Sci 2019 Feb 20;357(2):111-115. Epub 2018 Nov 20.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) mediates programmed cell death signaling as well as the Fas-induced cell death pathway. The downregulation of TRADD is found to be associated with the occurrence of many cancers. The present study was designed to investigate the association between TRADD and clinicopathologic features as well as its clinical significance in acute myeloid leukemia (AML). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183041
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http://dx.doi.org/10.1016/j.amjms.2018.10.015DOI Listing
February 2019
7 Reads
1.515 Impact Factor

Impact of Delayed Appropriate Antibiotic Therapy on Patient Outcomes by Antibiotic Resistance Status From Serious Gram-negative Bacterial Infections.

Am J Med Sci 2019 Feb 22;357(2):103-110. Epub 2018 Nov 22.

Albany College of Pharmacy and Health Sciences, Albany, New York.

Background: To examine the clinical and economic burdens associated with delayed receipt of appropriate therapy among patients with Gram-negative bacteria (GNB) infections, stratified by antibiotic resistance status.

Materials And Methods: Retrospective analysis using the Premier Hospital Database. Adult admissions (July 2011-September 2014) with evidence of complicated urinary tract infection, complicated intra-abdominal infection, hospital-associated pneumonia, or bloodstream infection, length of stay (LOS) ≥1 days and a positive GNB culture from a site consistent with infection type (culture draw date = index date) were identified and stratified by antibiotic susceptibility to index pathogens. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.009DOI Listing
February 2019
3 Reads

Hepatotoxicity and Recurrent NSTEMI While on Pembrolizumab for Metastatic Giant Cell Bone Tumor.

Am J Med Sci 2019 Apr 29;357(4):343-347. Epub 2018 Nov 29.

Department of Medicine, University of Illinois Chicago, Chicago, Illinois; Division of Hematology/Oncology, University of Illinois Chicago, Chicago, Illinois.

We present the first reported case showing metastatic giant bone cell tumor being treated successfully with pembrolizumab after failing prior tyrosine kinase inhibitor therapy. Of note, the patient developed multiple systemic effects associated with checkpoint inhibitor use. One year after starting the checkpoint inhibitor (ICI), the patient also developed hepatitis that was confirmed by liver biopsy and pathology to be, in part, due to drug-mediated toxicity similar to prior ICI toxicity cases that have been reported. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.017DOI Listing
April 2019
7 Reads

The Role of Plasmapheresis in Treating Lethal Cupric Sulfate Poisoning.

Authors:
Yu Du Yi Mou

Am J Med Sci 2019 Apr 29;357(4):338-342. Epub 2018 Nov 29.

Geroscience and Chronic Disease Department, The 8th Municipal People's Hospital, Chengdu, China. Electronic address:

The mortality rate of cupric sulfate is relatively high in contrast to that of other heavy metals. Cases of orally ingested cupric sulfate poisoning are very rare, with a reported half lethal dose of 10 g. Cupric sulfate poisoning leads to gastrointestinal corrosion, intravascular hemolysis, hemolytic anemia, methemoglobinemia and acute renal and hepatic impairment. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.014DOI Listing
April 2019
3 Reads

Serum Peroxisome Proliferator-activated Receptor Gamma Coactivator-1α Related to Myocardial Energy Expenditure in Patients With Chronic Heart Failure.

Am J Med Sci 2019 Mar 7;357(3):205-212. Epub 2018 Dec 7.

State Key Laboratory of Organ Failure Research, Department of Cardiology and; Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Key Laboratory For Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, Guangdong, China. Electronic address:

Background: Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) plays key roles in controlling cardiac metabolism and function. Myocardial energy expenditure (MEE) can reflect myocardial energy metabolism and cardiac function. Whether the variation of PGC-1α can influence MEE levels in chronic heart failure (CHF) is unclear. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.12.002DOI Listing
March 2019
2 Reads

Transmission Electron Microscopy Improves the Diagnostic Sensitivity in Nonbacterial Etiology of Severe Pneumonia: A Retrospective Study.

Am J Med Sci 2019 Apr 27;357(4):289-295. Epub 2018 Nov 27.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Background: Severe pneumonia is responsible for great mortality and morbidity worldwide, and early-applied effective anti-infective therapy can improve the prognosis of patients. However, identification of infectious agents in severe pneumonia remains a major challenge so far. In this study, the potential utility of transmission electron microscopy (TEM) in detecting nonbacterial pathogens in patients with severe pneumonia was retrospectively evaluated. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.012DOI Listing
April 2019
2 Reads