17,690 results match your criteria Am. J. Clin. Pathol.[Journal]


The Uterine Plexiform Lesions Revisited.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, University Hospital of Saint-Etienne, France.

Objectives: Uterine lesions with plexiform morphology are uncommon lesions with debated histogenesis. Despite being an incidental and usually benign finding (plexiform tumorlet), some cases can pose diagnostic problems. Their paucity in the recent literature adds to these difficulties and often causes ambiguities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa054DOI Listing

Predominant Stroma-Rich Feature in Hyaline Vascular Variant of Castleman Disease Is Associated With Paraneoplastic Pemphigus.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Peking University First Hospital, Beijing, China.

Objectives: We aimed to describe the clinical and histopathologic features of Castleman disease (CD), particularly emphasizing its associations with paraneoplastic pemphigus (PNP) and prognosis.

Methods: We retrospectively enrolled 123 CD patients at our center. Clinical, pathologic, and laboratory data were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa053DOI Listing

Four-Year Experience of Digital Slide Telepathology for Intraoperative Frozen Section Consultations in a Two-Site French Academic Department of Pathology.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, AP-HP-Université Paris Saclay, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Objectives: To share our experience with digital slide telepathology for intraoperative frozen section consultations (IOCs) and to describe its evolution over time by reporting performance metrics and addressing organizational and economic aspects.

Methods: Since 2013, a technician has been alone at the surgical site. At the other site, the pathologist opens the digital slide from a local server via the intranet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa055DOI Listing

How I Diagnose Low-Grade Myelodysplastic Syndromes.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, Massachusetts General Hospital, Boston.

Objectives: Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms that are often difficult to diagnose due to their pathologic and clinical heterogeneity. The key features of MDS are peripheral blood cytopenias, ineffective hematopoiesis manifesting as morphologic dysplasia, and clonal genetic abnormalities. The most difficult diagnostic dilemmas often arise in low-grade MDS cases (lacking excess blasts), which can be difficult to distinguish from other causes of cytopenia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa046DOI Listing

How I Diagnose.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa034DOI Listing

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.

Am J Clin Pathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Objectives: To report methods and findings of 2 autopsies with molecular evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals.

Methods: Postmortem examination was completed following Centers for Disease Control and Prevention public guidelines. Numerous formalin-fixed paraffin-embedded (FFPE) tissue types from each case were surveyed for SARS-CoV-2 RNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa091DOI Listing

Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?

Am J Clin Pathol 2020 May 23. Epub 2020 May 23.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Objectives: The possibility of a so-called primary lymph node neuroendocrine carcinoma has been described in the literature. Here we evaluate cases fitting such a diagnosis and find that the cases demonstrate a convincing and pervasive pattern consistent with metastatic Merkel cell carcinoma.

Methods: Six cases of primary lymph node Merkel cell carcinoma and one case of metastatic neuroendocrine carcinoma at a bony site, all with unknown primary, were sequenced using a combination of whole-exome and targeted panel methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa051DOI Listing

Serology Is More Sensitive Than Urea Breath Test or Stool Antigen for the Initial Diagnosis of Helicobacter pylori Gastritis When Compared With Histopathology.

Am J Clin Pathol 2020 May 23. Epub 2020 May 23.

Department of Laboratory Medicine, University of Washington, Seattle.

Objectives: To assess the concordance and performance characteristics of Helicobacter pylori laboratory tests compared with histopathology and to propose algorithms for the diagnosis of H pylori that minimize diagnostic error.

Methods: H pylori diagnostics were reviewed from a 12-year period within a health system (2,560 cases). Analyses were performed to adjust diagnostic performance based on treatment and consensus histopathologic diagnoses among pathologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa043DOI Listing

Cryoprecipitate Utilization Patterns Observed With a Required Prospective Approval Process vs Electronic Dosing Guidance.

Am J Clin Pathol 2020 May 23. Epub 2020 May 23.

Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: We evaluated the impact of electronic medical record (EMR)-guided pooled cryoprecipitate dosing vs our previous practice of requiring transfusion medicine (TM) resident approval for every cryoprecipitate transfusion.

Methods: At our hospital, cryoprecipitate pooled from five donors is dosed for adult patients, while single-donor cryoprecipitate is dosed for pediatric patients (defined as patients <50 kg in weight). EMR-based dosing guidance replaced a previously required TM consultation when cryoprecipitate pools were ordered, but a consultation remained required for single-unit orders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa042DOI Listing

Molecular/Cytogenetic Education for Hematopathology Fellows.

Am J Clin Pathol 2020 May 23. Epub 2020 May 23.

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora.

Objectives: At a discussion on molecular/cytogenetic education for hematopathology fellows at the 2018 Society for Hematopathology Program Directors Meeting, consensus was that fellows should understand basic principles and indications for and limitations of molecular/cytogenetic testing used in routine practice. Fellows should also be adept at integrating results of such testing for rendering a final diagnosis. To aid these consensus goals, representatives from the Society for Hematopathology and the Association for Molecular Pathology formed a working group to devise a molecular/cytogenetic curriculum for hematopathology fellow education. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa038DOI Listing

Placental Pathology in COVID-19.

Am J Clin Pathol 2020 May 22. Epub 2020 May 22.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Objectives: To describe histopathologic findings in the placentas of women with coronavirus disease 2019 (COVID-19) during pregnancy.

Methods: Pregnant women with COVID-19 delivering between March 18, 2020, and May 5, 2020, were identified. Placentas were examined and compared to historical controls and women with placental evaluation for a history of melanoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa089DOI Listing

Antibody Testing For Covid-19.

Am J Clin Pathol 2020 May 15. Epub 2020 May 15.

Case Western Reserve University School of Dental Medicine, Cleveland, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa082DOI Listing

Reporting of Benign Endometrial Cells in Papanicolaou Tests.

Am J Clin Pathol 2020 May 14. Epub 2020 May 14.

Department of Pathology , NYU Langone Health, New York, NY.

Objectives: The 2014 Bethesda System (TBS 2014) guidelines for reporting cervical cytology revised the age for reporting benign endometrial cells (BECs) from 40 years or older to age 45 years or older. We evaluated this change and further investigated if extending the reporting age to 50 years or older may be acceptable.

Methods: We reviewed cases with BECs reported on Papanicolaou tests in women age 40 years or older and 45 years or older before and after implementation of TBS 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa041DOI Listing

Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity.

Am J Clin Pathol 2020 May 14. Epub 2020 May 14.

Department of Pathology, University of Utah, Salt Lake City.

Objectives: The World Health Organization recommends measurement of glucose-6-phosphate dehydrogenase (G6PD) activity before initiation of 8-aminoquinoline therapy. A new drug for malaria prophylaxis and treatment (tafenoquine) is contraindicated in patients with G6PD deficiency or unknown G6PD status given its prolonged half-life. Assessments of percentage of normal G6PD activity using laboratory-specific result distributions are not widely available, making tafenoquine-eligibility decisions potentially challenging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa040DOI Listing

Corrigendum.

Authors:

Am J Clin Pathol 2020 May;153(6):852

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa070DOI Listing

Histology-Independent Signature Distinguishes Kikuchi-Fujimoto Disease/Systemic Lupus Erythematosus-Associated Lymphadenitis From Benign and Malignant Lymphadenopathies.

Am J Clin Pathol 2020 May 5. Epub 2020 May 5.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

Objectives: Kikuchi-Fujimoto disease (KFD) and systemic lupus erythematosus (SLE) are benign entities with histologic features that raise concern about malignancy and infection. We searched for a histology-independent KFD/SLE signature relying on only immunophenotype and basic clinical characteristics.

Methods: A histology-independent KFD/SLE signature was generated using 975 excised lymph nodes with flow immunophenotyping, including 16 cases of KFD/SLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa036DOI Listing

Detection of Falsely Elevated Point-of-Care Potassium Results Due to Hemolysis Using Predictive Analytics.

Am J Clin Pathol 2020 May 5. Epub 2020 May 5.

Department of Pathology, NorthShore University HealthSystem, Evanston, IL.

Objectives: Preanalytical factors, such as hemolysis, affect many components of a test panel. Machine learning can be used to recognize these patterns, alerting clinicians and laboratories to potentially erroneous results. In particular, machine learning might identify which cases of elevated potassium from a point-of-care (POC) basic metabolic panel are likely erroneous. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa039DOI Listing

cDNA-Based Mutation Screening Using a Combination of High-Resolution Melting Curve and Fragment Analysis Facilitates Efficient CCR4 Mutation Analysis in Adult T-Cell Leukemia/Lymphoma.

Am J Clin Pathol 2020 May 5. Epub 2020 May 5.

Laboratory of Hematology, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Hyogo, Japan.

Objectives: C-C chemokine receptor type 4 (CCR4) proteins are expressed on the neoplastic cells of adult T-cell leukemia/lymphoma (ATLL). As the mutation status of CCR4 gene is reported to correlate with significant clinical information such as prognosis and response to mogamulizumab, we aimed to establish a screening method that is suitable for clinical laboratory tests.

Methods: In 34 patients with ATLL, CCR4 mutation analysis, high-resolution melting (HRM) analysis, fragment analysis, and direct sequencing were performed using both genomic DNA and complementary DNA (cDNA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa037DOI Listing

The Burden of Placental Histopathology in Stillbirths Associated With Maternal Obesity.

Am J Clin Pathol 2020 Apr 27. Epub 2020 Apr 27.

Department of Health Sciences, San Paolo Hospital Medical School, University of Milan, Milan, Italy.

Objectives: Obesity is an increasing health problem that has become a common medical disorder among women of childbearing age, representing worldwide a risk factor for stillbirth. The aim of the study is to evaluate the association between placental histopathologic findings and obesity in stillbirth.

Methods: Placentas were analyzed according to the Amsterdam consensus statement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa035DOI Listing

Double-Edged Spike.

Am J Clin Pathol 2020 May;153(6):709-711

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188132PMC

Amplification of MDM2 and Loss of p16 Expression: Do They Have a Role in Malignant Transformation of Ovarian Brenner Tumor?

Am J Clin Pathol 2020 Apr 23. Epub 2020 Apr 23.

Department of Pathology, NYU Langone Medical Center, New York, NY.

Objectives: To review the significance of MDM2 and cyclin D1 expression and loss of p16 expression in malignant and borderline Brenner tumors (BTs) of the ovary.

Methods: We describe 2 new cases of ovarian BT, 1 malignant and 1 borderline. We studied MDM2, p16, and cyclin D1 expression by immunohistochemistry in the benign, borderline, and malignant components of these 2 cases and in 5 additional cases of benign BT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa033DOI Listing

Extranodal Marginal Zone Lymphoma of the Central Nervous System Includes Parenchymal-Based Cases With Characteristic Features.

Am J Clin Pathol 2020 Apr 22. Epub 2020 Apr 22.

Department of Laboratory Medicine, Robert J. Tomisch Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.

Objectives: To define the clinicopathologic features of extranodal marginal zone lymphoma (EMZL) of the central nervous system (CNS), including cases arising in CNS parenchyma, which have been reported only rarely.

Methods: Twelve cases of CNS EMZL were identified, including 5 based in CNS parenchyma and 7 nonparenchymal cases arising in dura or choroid plexus.

Results: Histologically, parenchymal cases were perivascular infiltrates without a dominant lymphoid mass, whereas nonparenchymal cases were masses of small lymphocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa032DOI Listing

Assessment of Specimen Pooling to Conserve SARS CoV-2 Testing Resources.

Am J Clin Pathol 2020 05;153(6):715-718

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.

Objectives: To establish the optimal parameters for group testing of pooled specimens for the detection of SARS-CoV-2.

Methods: The most efficient pool size was determined to be five specimens using a web-based application. From this analysis, 25 experimental pools were created using 50 µL from one SARS-CoV-2 positive nasopharyngeal specimen mixed with 4 negative patient specimens (50 µL each) for a total volume of 250 µL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188150PMC

Understanding the Dynamics of COVID-19.

Authors:
Robin Vollmer

Am J Clin Pathol 2020 05;153(6):850-851

Department of Pathology, Durham Veterans Affairs Hospital, Durham, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184516PMC

COVID-19 Autopsies, Oklahoma, USA.

Am J Clin Pathol 2020 05;153(6):725-733

Department of Pathology, Cleveland Clinic, Cleveland, OH.

Objectives: To report the methods and findings of two complete autopsies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals who died in Oklahoma (United States) in March 2020.

Methods: Complete postmortem examinations were performed according to standard procedures in a negative-pressure autopsy suite/isolation room using personal protective equipment, including N95 masks, eye protection, and gowns. The diagnosis of coronavirus disease 2019 (COVID-19) was confirmed by real-time reverse transcriptase polymerase chain reaction testing on postmortem swabs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184436PMC

Morphologic and Immunocytochemical Features of High-Grade Serous Carcinoma of Ovary in Ascitic Fluid Effusion and Fine-Needle Aspiration Cytology.

Am J Clin Pathol 2020 Apr 7. Epub 2020 Apr 7.

Cytology and Gynaecological Pathology, Chandigarh, India.

Objectives: High-grade serous carcinoma (HGSC) is the most common ovarian malignancy. The role of cytopathology in obtaining tissue diagnosis before institution of neoadjuvant chemotherapy (NACT) was evaluated.

Methods: All histopathology-proven HGSC specimens between 2015 and 2018 with prior cytopathologic diagnosis by ascitic fluid evaluation or fine-needle aspiration (FNA) of ovarian mass were reviewed with cell block immunocytochemistry for CK7, CK20, PAX8, WT1, and p53. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa028DOI Listing

Evaluation of the Reticulocyte Production Index in the Pediatric Population.

Am J Clin Pathol 2020 Apr 9. Epub 2020 Apr 9.

Laboratory of Hematology, Luis Calvo Mackenna Hospital, Santiago, Chile.

Objectives: Since hematologic values vary with age in children, we evaluated the agreement between the "traditional" reticulocyte production index (RPI) and an RPI by age (RPI/A)-adjusted normal values.

Methods: A retrospective, observational, and analytical study was performed on CBCs of children with anemia younger than 18 years. The agreement and clinical repercussions of the RPI values were analyzed with an RPI/A developed with theoretical values for different ages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa020DOI Listing

Bladder Cancer Involving Smooth Muscle of Indeterminate Type or Muscularis Mucosae in Transurethral Biopsy Specimens.

Am J Clin Pathol 2020 Apr 7. Epub 2020 Apr 7.

Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston.

Objectives: Bladder cancers invading the muscularis mucosae (MM) are treated differently from those invading the muscularis propria (MP). However, it may be difficult to determine the type of smooth muscle in transurethral resection (TUR) or biopsy specimens. We aimed to investigate the clinicopathologic features of bladder cancers involving smooth muscle of indeterminate type (SMIT) in TUR specimens in comparison with those invading the MM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa030DOI Listing

Performance and Utilization of a Laboratory-Developed Nucleic Acid Amplification Test (NAAT) for the Diagnosis of Pulmonary and Extrapulmonary Tuberculosis in a Low-Prevalence Area.

Am J Clin Pathol 2020 Apr 4. Epub 2020 Apr 4.

Departments of 1Pathology and Laboratory Medicine, Evanston, IL.

Objectives: Tuberculosis (TB) is a significant global health problem. In low-prevalence areas and low clinical suspicion, nucleic acid amplification tests (NAAT) for direct detection of Mycobacterium tuberculosis complex (MTBC) can speed therapy initiation and infection control. An NAAT assay (TBPCR) targeting MTBC IS6110 is used for detecting MTBC in our low-prevalence population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa031DOI Listing

Discrepant Hemophilia A: An Underdiagnosed Disease Entity.

Am J Clin Pathol 2020 Mar 31. Epub 2020 Mar 31.

Department of Pathology and Laboratory Medicine, University of Iowa Carver College of Medicine, Iowa City.

Objectives: The term discrepant hemophilia A (DHA) denotes the discrepancy between factor VIII activity (FVIII:C) measured by different assay methodologies in patients with nonsevere hemophilia A (HA). The objective was to review the characteristics and the current understanding of mechanisms contributing to assay discrepancy in DHA.

Methods: Characteristics of the DHA patients treated were examined by retrospective chart review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa024DOI Listing

SARS-CoV-2 Testing.

Am J Clin Pathol 2020 05;153(6):706-708

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184440PMC

What Constitutes Optimal Cervical Screening for Young Women Ages 21 to 29 Years?

Am J Clin Pathol 2020 May;153(6):712-714

Magee-Womens Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa025DOI Listing

Impact of the Current US Preventive Services Task Force Recommendations for Cervical Cancer Screening in Young Women 21 to 29 Years Old.

Am J Clin Pathol 2020 May;153(6):734-742

Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD.

Objectives: In 2012, the US Preventive Services Task Force decreased the recommended frequency of cervical cytology screening to once every 3 years and recommended against testing women younger than 21 years regardless of sexual history. We evaluated the impact of this in 21 to 29-year-old women at a tertiary care academic medical center in 2011 and 2017.

Methods: We retrospectively analyzed Papanicolaou test results at two time points in 21- to 29-year-old women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa012DOI Listing

Prognostic Impact of Histopathologic Features in Pulmonary Invasive Mucinous Adenocarcinomas.

Am J Clin Pathol 2020 Mar 26. Epub 2020 Mar 26.

Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan.

Objectives: The prognostic significance of pathologic features and invasive size has not been well studied for invasive mucinous adenocarcinoma (IMA). This study evaluates the significance of pathologic features and invasive size in relation to clinical outcome.

Methods: We reviewed the pathologic features in 84 IMAs, including histologic pattern, nuclear atypia, mitosis, necrosis, and lymphovascular invasion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa026DOI Listing

Primary Cutaneous Clear Cell Sarcoma, Clinical Outcome With Sentinel Lymph Nodes Status.

Am J Clin Pathol 2020 May;153(6):799-810

Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark.

Objectives: Primary cutaneous clear cell sarcoma (PCS) is a rare malignancy and difficult to differentiate from melanoma. We investigated factors influencing survival and recurrence.

Methods: An institutional cancer registry and literature search were used for a retrospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa009DOI Listing

Establishing a Satellite Transfusion Service Within an Academic Medical Center.

Am J Clin Pathol 2020 May;153(6):842-849

Division of Transfusion Medicine, Department of Pathology, Stanford Medicine, Stanford, CA.

Objectives: Increasingly complex medical care requires specialized transfusion support close at hand. Hospital growth can necessitate expansion of blood bank services to new locations to ensure rapid delivery of blood products. We describe the opening of a new satellite transfusion service designed to serve the needs of a pediatric hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa018DOI Listing

Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer.

Am J Clin Pathol 2020 May;153(6):833-841

Department of Surgical Oncology, First Affiliated Hospital of China Medical University, Shenyang, China.

Objectives: To evaluate the prognostic significance of lymphovascular invasion (LVI) for patients with gastric cancer (GC).

Methods: A total of 1,720 consecutive patients who underwent curative gastrectomy were retrospectively identified. The association between LVI and clinicopathologic characteristics was determined and its impact on survival outcome was evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa021DOI Listing

Synchronous Pulmonary Adenocarcinomas.

Am J Clin Pathol 2020 Mar 8. Epub 2020 Mar 8.

Department of Pathology and Cell Biology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital, New York, NY.

Objectives: To determine concordance/discordance between morphology and molecular testing (MT) among synchronous pulmonary carcinomas using targeted next generation sequencing (NGS), with and without comprehensive molecular review (CMR), vs analyses of multiple singe genes (non-NGS).

Methods: Results of morphologic and MT assessment were classified as concordant, discordant, or indeterminate. For discordant cases, comprehensive histologic assessment (CHA) was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa023DOI Listing

Is the Utilization of Helicobacter pylori Stool Antigen Tests Appropriate in an Urban Canadian Population?

Am J Clin Pathol 2020 Apr;153(5):686-694

Departments of Pathology and La Medicine.

Objectives: Helicobacter pylori stool antigen test (HpSAT) appropriateness was investigated by assessing its testing and positivity rates in Calgary, Canada.

Methods: The laboratory information system was accessed for all patients who received an HpSAT in 2018. Testing volume, test results, age, and sex of patients were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqz210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159178PMC

Clinicopathologic Analysis of Oral and Maxillofacial Solitary Fibrous Tumor.

Am J Clin Pathol 2020 Mar 5. Epub 2020 Mar 5.

Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.

Objectives: The aim of this systematic review was to provide an overview of the oral and maxillofacial solitary fibrous tumor (SFT) in order to determine its clinicopathologic characteristics and biological behavior.

Methods: We conducted a systematic review in May 2019 in multiple databases. Cases diagnosed as SFT in the oral cavity and maxillofacial complex were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa027DOI Listing

Therapeutic Phlebotomy for Testosterone-Induced Polycythemia.

Am J Clin Pathol 2020 Mar 5. Epub 2020 Mar 5.

Physician Services, Division of New York Blood Center, St Paul, MN.

Objectives: To evaluate therapeutic phlebotomy (TP) requests for testosterone replacement therapy (TRT) and to highlight the impact to a blood center (BC) or service that provides TP for individuals on TRT.

Methods: Review of TP requests for individuals on TRT at our BC over a 3-year period from 2014 through 2016, as well as the total number of TP collections.

Results: Total TPs during 2014, 2015, and 2016 were 475, 500, and 569, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa019DOI Listing
March 2020
2.514 Impact Factor

TdT Expression Is a Marker of Better Survival in Merkel Cell Carcinoma, and Expression of B-Cell Markers Is Associated With Merkel Cell Polyomavirus.

Am J Clin Pathol 2020 Mar 5. Epub 2020 Mar 5.

Department of Pathology, Center of Oncology, M. Sklodowska-Curie Memorial Institute, Krakow, Poland.

Objectives: Merkel cell carcinoma is a rare but very aggressive cutaneous tumor. We evaluated the prognostic potential of B-cell markers (terminal deoxynucleotidyl transferase [TdT], PAX5, CD117), follicular stem cell markers (CK15, CK19), p63, p53, RB, and Merkel cell polyomavirus (MCPyV; CM2B4) in 136 primary cutaneous Merkel cell carcinomas.

Methods: Clinical, histopathologic, and immunohistochemical analyses were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa017DOI Listing
March 2020
2.514 Impact Factor

INSM1 Is a Highly Specific Marker of Neuroendocrine Differentiation in Primary Neoplasms of the Gastrointestinal Tract, Appendix, and Pancreas.

Am J Clin Pathol 2020 May;153(6):811-820

Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH.

Objectives: INSM1 has been described as a sensitive and specific neuroendocrine marker. This study aims to compare INSM1 with traditional neuroendocrine markers in gastrointestinal neuroendocrine neoplasms.

Methods: Retrospective review (2008-2018) was used to retrieve paraffin-embedded tissue from 110 gastrointestinal neuroendocrine neoplasms and controls that was subsequently stained with INSM1, synaptophysin, chromogranin, CD56, and Ki-67. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa014DOI Listing

Double-Hit and Triple-Hit Follicular Lymphoma.

Am J Clin Pathol 2020 Apr;153(5):672-685

Department of Pathology & Laboratory Medicine, Emory University Hospital, Atlanta, GA.

Objectives: To better characterize the clinicopathologic presentation and outcomes of follicular lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-hit and triple-hit follicular lymphoma), we present three cases from our institution and perform a literature review of 37 published cases.

Methods: Cases were identified using institutional SoftPath software and the MEDLINE database via the PubMed search engine. Clinical and pathologic data were collected with subsequent stratification by histologic grade and treatment for comparison. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqz208DOI Listing

Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance.

Am J Clin Pathol 2020 Feb 29. Epub 2020 Feb 29.

Department of Hematopathology and Lab Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Objectives: To compare the clinical significance of SF3B1/DNMT3A Comutations with SF3B1 or DNMT3A mutation alone in myelodysplastic syndrome (MDS) and clonal cytopenia of undetermined significance (CCUS).

Methods: We identified and compared 31 patients with only DNMT3A mutation, 48 patients with only SF3B1 mutation, and 16 patients with only SF3B1/DNMT3A comutations.

Results: SF3B1/DNMT3A comutations were found to be more common in MDS, whereas DNMT3A mutation alone was more common in CCUS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa016DOI Listing
February 2020
2.514 Impact Factor

Histologic and Laboratory Characteristics of Symptomatic and Asymptomatic Castleman Disease in the Pediatric Population.

Am J Clin Pathol 2020 May;153(6):821-832

Department of Pathology, Boston Children's Hospital, Boston, MA.

Objectives: Compare the morphologic, laboratory, and clinical features of asymptomatic and symptomatic Castleman disease in the pediatric population.

Methods: We reviewed clinical records and histopathology of patients with Castleman disease from 2 pediatric institutions.

Results: Of 39 patients with pediatric Castleman disease, 37 had unicentric disease, all classified with the hyaline vascular variant of Castleman disease, 8 of which were clinically symptomatic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa011DOI Listing

Changes in Mean Corpuscular Volume and RBC Distribution Width Predict Erythrocyte Engraftment Following ABO-Incompatible Hematopoietic Stem Cell Transplantation.

Am J Clin Pathol 2020 May;153(6):781-789

Department of Pathology, Virginia Commonwealth University, Richmond.

Objectives: The purpose of this study was to identify laboratory parameters representing erythrocyte engraftment to be used as an indicator to change the recipient to donor ABO group and Rh type following an ABO-incompatible hematopoietic stem cell transplant (HSCT). Studies have shown that ABO incompatibility does not have an effect on outcome of HSCT; however, the serologic consequences of these ABO-incompatible transplants can make it difficult to decide when to begin support with donor ABO/Rh-type blood products.

Methods: This study explored the use of RBC distribution width (RDW), mean corpuscular volume, and hemoglobin as regularly tested laboratory parameters that could be used as surrogate markers for RBC engraftment in 65 patients who received ABO/Rh-incompatible HSCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa006DOI Listing

The American Society for Clinical Pathology's Job Satisfaction, Well-Being, and Burnout Survey of Pathologists.

Am J Clin Pathol 2020 Mar;153(4):435-448

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.

Objectives: To examine job satisfaction, well-being, job stress, and burnout among pathologists.

Methods: The study utilized a cross-sectional survey design. The survey was administered online via the American Society for Clinical Pathology's (ASCP's) survey tool to elicit information about job satisfaction, well-being, job stress, and burnout among pathologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcp/aqaa010DOI Listing