322 results match your criteria Am J Nucl Med Mol Imaging[Journal]


Global quantification of pulmonary artery atherosclerosis using F-sodium fluoride PET/CT in at-risk subjects.

Am J Nucl Med Mol Imaging 2020 15;10(2):119-126. Epub 2020 Apr 15.

Department of Radiology, Hospital of The University of Pennsylvania Philadelphia, PA, USA.

The goal of this study was to assess pulmonary artery calcification in healthy controls and subjects with suspicion of stable angina pectoris through the usage of quantitative F-sodium fluoride positron emission tomography/computed tomography (NaF-PET/CT). We hypothesized that these 'at-risk subjects' would demonstrate increase pulmonary artery NaF uptake compared to healthy controls. Retrospectively, 15 healthy controls were compared to 15 at-risk subjects, all of whom underwent full-body NaF-PET/CT scans. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218698PMC

Accuracy of Ga-PSMA-11 PET/CT and multiparametric MRI for the detection of local tumor and lymph node metastases in early biochemical recurrence of prostate cancer.

Am J Nucl Med Mol Imaging 2020 15;10(2):106-118. Epub 2020 Apr 15.

Center of Urology, Pauls Stradins Clinical University Hospital Riga, Latvia.

Anatomical and functional imaging plays a decisive role for detection and staging, of prostate cancer both primarily and post-treatment. While multiparametric MRI offers anatomic imaging with excellent soft tissue contrast, hybrid imaging based on positron emission tomography in combination with computed tomography (PET/CT) contributes functional imaging capacities. Since Ga-PSMA-11 was expected to be more efficient than the prior Choline-based PET radiotracers, it was the aim of the study to evaluate the diagnostic performance of the Ga-PSMA-11 PET/CT and multiparametric MRI in patients with recurrent prostate cancer and low PSA levels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218697PMC

Development of zirconium-89 PET for imaging of alpha-klotho.

Am J Nucl Med Mol Imaging 2020 15;10(2):95-105. Epub 2020 Apr 15.

Preclinical Imaging, Radiological Sciences, University of California-Irvine Irvine, CA 92697, USA.

Alpha-klotho is a single-pass membrane protein primarily expressed by the kidneys. Klotho deficiency in chronic kidney disease contributes to an accelerated aging phenotype. We report here development of [Zr]DFO-anti-klotho positron emission tomography (PET) imaging as a novel non-invasive method for assessing whole-body alpha-klotho distribution. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218695PMC

PET/CT in pediatric oncology.

Am J Nucl Med Mol Imaging 2020 15;10(2):83-94. Epub 2020 Apr 15.

PET/CT Section, Pio XI Private Hospital Rome, Italy.

The use of PET/CT in adult oncology has been consolidated by several and authoritative multicentric studies, metanalyses and systematic reviews. International guidelines help everyday nuclear medicine specialists, oncologists and radiologists in choosing the most suitable diagnostic path for each patient. Classifications based on traditional imaging and PET/CT findings define the most appropriate treatment and can predict the outcome for different types of malignancies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218696PMC

F-FDG PET/CT imaging features of lipomatous tumors.

Am J Nucl Med Mol Imaging 2020 25;10(1):74-82. Epub 2020 Feb 25.

Department of Radiology, Mayo Clinic Rochester, MN 55905, US.

The objective was to evaluate the F-FDG PET/CT characteristics of lipomatous tumors, and examine features helpful in differentiating benign from malignant tumor subtypes. Patients undergoing F-FDG PET/CT from 01/2005 to 03/2018 with subsequent pathologically confirmed liposarcoma, lipoma, or hibernoma were retrospectively reviewed with IRB approval. A variety of imaging features, including metabolic activity and tumor morphology were noted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076300PMC
February 2020

F-FDG-PET/CT in the quantification of photon radiation therapy-induced vasculitis.

Am J Nucl Med Mol Imaging 2020 25;10(1):66-73. Epub 2020 Feb 25.

Department of Radiology, University of Pennsylvania Philadelphia, PA, USA.

Radiation therapy (RT) is an important component of care for head and neck cancers (HNC). Photon RT vasculitis is a complication of incidental dose delivery to nearby vascular structures. However, optimal methods for early diagnosis are not clearly established. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076303PMC
February 2020

Assessing bladder hyper-permeability biomarkers using molecularly-targeted MRI.

Am J Nucl Med Mol Imaging 2020 25;10(1):57-65. Epub 2020 Feb 25.

Department of Urology, University of Oklahoma Health Sciences Center Oklahoma, OK, USA.

The objective was to investigate if some of the key molecular players associated with bladder hyper-permeability in interstitial cystitis/bladder pain syndrome (IC/BPS) could be visualized with molecularly-targeted magnetic resonance imaging (mt-MRI) . IC/BPS is a chronic, painful condition of the bladder that affects primarily women. It has been demonstrated over the past several decades that permeability plays a substantial role in IC/BPS. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076299PMC
February 2020

Role of F-NaF-PET in assessing aortic valve calcification with age.

Am J Nucl Med Mol Imaging 2020 25;10(1):47-56. Epub 2020 Feb 25.

Department of Radiology, University of Pennsylvania Philadelphia, United States.

Aortic valve calcification is a slow and progressive pathological process that can manifest in various degrees from mild thickening of the valve known as aortic sclerosis to severe calcification that hinders the leaflet motion, known as aortic stenosis. The evolving concept of aortic calcification is thought to result from infiltration of macrophages and T-lymphocytes. Moreover, the incidence of aortic valve calcification increases with age, in particular over the age of 50. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076301PMC
February 2020

[Tc]-labelled interleukin-8 as a diagnostic tool compared to [F]FDG and CT in an experimental porcine osteomyelitis model.

Am J Nucl Med Mol Imaging 2020 25;10(1):32-46. Epub 2020 Feb 25.

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen Copenhagen, Denmark.

Osteomyelitis (OM) is an important cause of morbidity and sometimes mortality in children and adults. Long-term complications can be reduced when treatment is initiated in an early phase. The diagnostic gold standard is microbial examination of a biopsy and current non-invasive imaging methods are not always optimal. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076304PMC
February 2020

Imaging of intranasal drug delivery to the brain.

Am J Nucl Med Mol Imaging 2020 25;10(1):1-31. Epub 2020 Feb 25.

Department of Radiology, University of Chicago School of Medicine USA.

Intranasal (IN) delivery is a rapidly developing area for therapies with great potential for the treatment of central nervous system (CNS) diseases. Moreover, in vivo imaging is becoming an important part of therapy assessment, both clinically in humans and translationally in animals. IN drug delivery is an alternative to systemic administration that uses the direct anatomic pathway between the olfactory/trigeminal neuroepithelium of the nasal mucosa and the brain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076302PMC
February 2020

Dynamic monitoring of STAT3 activation in live cells using a novel STAT3 Phospho-BRET sensor.

Am J Nucl Med Mol Imaging 2019 15;9(6):321-334. Epub 2019 Dec 15.

Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre Navi Mumbai, India.

Phosphorylation (pY705) mediated homodimerization is a rate-limiting step controlling STAT3 key oncogenic functions making it an attractive target for drug discovery. Hence, this study reports development of a sensitive and versatile STAT3 Phospho-BRET biosensor platform technology to monitor activation dynamics of STAT3 signalling directly from live cells. Categorically, we first demonstrate that NanoLuc donor and TurboFP635 acceptor serves as an excellent BRET system over other tested fluorophores like mOrange and TagRFP, both for live cells as well as optical imaging of protein-protein interactions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971483PMC
December 2019

Reduction in amyloid β deposition on F-florbetapir positron emission tomography with correction of cerebral hypoperfusion after endarterectomy for carotid stenosis.

Am J Nucl Med Mol Imaging 2019 15;9(6):316-320. Epub 2019 Dec 15.

Department of Neurosurgery, Iwate Medical University Morioka, Iwate, Japan.

The process of amyloid β (Aβ) deposition in sporadic Alzheimer's disease remains unclear. However, hypoperfusion due to vascular pathology may precede Aβ deposition, as suggested by data from animal models and autopsy tissue from Alzheimer's disease patients. In this exploratory study, we examined the hypotheses that chronic cerebral hypoperfusion due to severe atherosclerotic stenosis of the internal carotid artery (ICA) increases Aβ deposition in the affected cerebral hemisphere and that correction of cerebral hypoperfusion after carotid endarterectomy (CEA) in such patients reduces Aβ deposition. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971482PMC
December 2019

Assessing respitatory muscle activity with F-FDG-PET/CT in patients with COPD.

Am J Nucl Med Mol Imaging 2019 15;9(6):309-315. Epub 2019 Dec 15.

Department of Radiology, Hospital of University of Pennsylvania Philadelphia, PA, USA.

The purpose of this study was to investigate the metabolic activity of the respiratory muscles in patients with chronic obstructive pulmonary diseases (COPD) and correlate with pulmonary function test results. Thirty-three male patients with a past medical history of smoking and COPD referred to 2-deoxy-2-[F]-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) because of clinical suspicion of pulmonary cancer were included. The degree of F-FDG uptake was visually quantified (grade 0-3) in the respiratory muscles of the neck, intercostal muscles, and abdominal muscles using mediastinal blood pool uptake and liver uptake as references. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971478PMC
December 2019

[Zr]Zr-rituximab PET/CT activity in patients with therapy refractory interstitial pneumonitis: a feasibility study.

Am J Nucl Med Mol Imaging 2019 15;9(6):296-308. Epub 2019 Dec 15.

Department of Nuclear Medicine, St. Antonius Hospital Nieuwegein, The Netherlands.

Recent studies on immune-mediated inflammatory lung diseases show encouraging treatment results with rituximab, a monoclonal antibody (mAb) against CD20-expressing B lymphocytes. The present pilot study aimed to explore the possibility to image CD20-expression in the lungs as future early predictor of treatment response. We describe a series of 10 patients with therapy refractory interstitial pneumonitis who were treated with rituximab (1000 mg at day 0 and day 14) and underwent PET/CT after the administration of [Zr]Zr--suc-DFO-rituximab abbreviated as [Zr]Zr-rituximab. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971479PMC
December 2019

Preliminary data on circulating tumor cells in metastatic NSCLC patients candidate to immunotherapy.

Am J Nucl Med Mol Imaging 2019 15;9(6):282-295. Epub 2019 Dec 15.

Nuclear Medicine, Humanitas Clinical and Research Hospital-IRCCS Via Manzoni 56, Rozzano (MI) 20089, Italy.

In the current paper, we aimed to investigate circulating tumor cells (CTCs) in non-small cell lung carcinoma (NSCLC) candidates to immunotherapy and correlate findings with clinical and metabolic parameters. Seventeen metastatic NSCLC patients (12 males, 5 females), were prospectively enrolled. All patients underwent F-Fluorodeoxyglucose (FDG) PET/CT and CTCs detection before treatment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971481PMC
December 2019

Quantification methods comparison in brain F-FDOPA PET.

Am J Nucl Med Mol Imaging 2019 15;9(6):274-281. Epub 2019 Dec 15.

Molecular Imaging Department, Fleni. Ruta 9, Km 52.5, B1625XAF Escobar, Buenos Aires, Argentina.

F-FDOPA PET is one of the most widely used molecular imaging techniques to assess presynaptic dopaminergic activity. A variety of analytical methods have been developed to quantify F-FDOPA PET images and in most, the striatal-to-occipital ratio (SOR) is used as a quantitative parameter. A manual strategy is typically used for quantification purposes, which can have some caveats, being time-consuming and having some inter-rater variability. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971484PMC
December 2019

An update on the role of F-FDG-PET/CT in major infectious and inflammatory diseases.

Am J Nucl Med Mol Imaging 2019 15;9(6):255-273. Epub 2019 Dec 15.

Department of Radiology, Hospital of University of Pennsylvania PA, USA.

For decades, conventional nuclear medicine techniques have been utilized for the assessment of many infectious and inflammatory diseases. Most of these techniques have limitations such as the relatively low spatial resolution, being time consuming and low sensitivity or specificity. In recent years, FDG-PET/CT has shown promising role in the management of such diseases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971480PMC
December 2019

Pretreatment volumetric parameters of FDG-PET predict the survival after Yttrium-90 radio-embolization in metastatic liver disease.

Am J Nucl Med Mol Imaging 2019 15;9(5):248-254. Epub 2019 Oct 15.

Department of Radiology, Hospital of University of Pennsylvania PA, USA.

This study aimed to determine the prognostic value of pretreatment FDG-PET in patients with metastatic liver disease undergoing Yttrium 90 (Y) radio-embolization using global disease assessment measures. Data from 16 patients with metastatic liver disease (8 males, 8 females) aged 55-97 years (mean: 67±12) were retrospectively collected. On PET, active malignant lesions in the liver were segmented with an adaptive thresholding system (ROVER software, ABX GmbH, Radeberg, Germany). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872476PMC
October 2019

Glucose-corrected standardized uptake value (SUV) is the most accurate SUV parameter for evaluation of pulmonary nodules.

Am J Nucl Med Mol Imaging 2019 15;9(5):243-247. Epub 2019 Oct 15.

Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.

Standardized uptake values (SUVs) of F-fluorodeoxyglucose positron emission tomography (FDG PET) are widely used to help characterize pulmonary nodules. The purpose of this study is to assess the accuracy of the SUV corrected by blood glucose levels (SUV), compared to four other commonly used semi-quantitative methods: maximal SUV normalized to body weight (SUV), ratio of SUV of nodule to cerebellum (SUV), SUV normalized to body surface area (SUV) and SUV normalized to body mass index (SUV). 52 patients with lung nodules had FDG PET scans, consecutively imaged between 7/1/2015 and 6/7/2016. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872475PMC
October 2019

Optical imaging with a novel cathepsin-activatable probe for enhanced detection of colorectal cancer.

Am J Nucl Med Mol Imaging 2019 15;9(5):230-242. Epub 2019 Oct 15.

Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Charlestown, MA, USA.

We evaluated a cysteine cathepsin-activatable optical imaging probe (LUM015) with improved kinetics relative to larger macromolecules for detection and characterization of colorectal cancer (CRC), and thereby assessed its potential use in fluorescence-guided colonoscopy. We showed that LUM015 is stable in plasma. In-vitro studies demonstrated selectivity of LUM015 for targeting cathepsins; there was robust increase in emitted fluorescence signal from the cathepsin overexpressing HT-29 CRC cells within 1-5 minutes after incubation with LUM015 compared to the cells incubated with combination of LUM015 and a pan-protease inhibitor (as negative control). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872479PMC
October 2019

Synthesis and assessment of ZD2-(Ga-NOTA) specific to extradomain B fibronectin in tumor microenvironment for PET imaging of pancreatic cancer.

Am J Nucl Med Mol Imaging 2019 15;9(5):216-229. Epub 2019 Oct 15.

Department of Biomedical Engineering, Case Western Reserve University Cleveland, OH 44106, USA.

Patients diagnosed with pancreatic cancer at a late stage have a dismal survival rate. Accurate early detection of pancreatic cancer with a size of 10 mm or less could dramatically improve patient survival after timely treatments. We have developed a new PET probe ZD2-(Ga-NOTA) specific to extradomain-B fibronectin (EDB-FN), an oncoprotein in tumor microenvironment, for sensitive molecular imaging and early diagnosis of pancreatic cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872477PMC
October 2019

SPECT and PET imaging of adrenomedullin receptors: a promising strategy for studying pulmonary vascular diseases.

Am J Nucl Med Mol Imaging 2019 15;9(5):203-215. Epub 2019 Oct 15.

University of Montreal Hospital Research Centre Montréal (Québec), Canada.

Circulating adrenomedullin (AM) levels are elevated in several cardiovascular diseases, including pulmonary vascular diseases causing pulmonary hypertension. To date the perfusion agent Tc-albumin macroaggregates (MAA) is the only approved radiopharmaceutical used for imaging of pulmonary circulation. Unlike Tc-MAA, imaging the AM receptors involves a molecular process dependent on the density of the receptors and the affinity of specific radioligands. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872478PMC
October 2019

Renal statistical map for positron emission tomography with [O-15] water.

Am J Nucl Med Mol Imaging 2019 15;9(4):193-202. Epub 2019 Aug 15.

Division of Integrated Renal Replacement Therapy, Tohoku University Graduate School of Medicine 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.

Image statistics are frequently used for functional and molecular imaging research in which images from a patient group with a specific diagnosis are compared with images from a healthy control group who have been matched for demographic variables. The success of image statistics for brain imaging has encouraged us to develop a method for obtaining volumetrically normalized kidney to perform image statistics so that we can locally visualize the statistical significant difference comparing voxel by voxel between certain groups in terms kidney blood flow kinetic parameters. For the development of this evolutionary process, we first volumetrically normalized all subjects, which include healthy control (HC) and chronic renal failure (CRF) patients, O water PET image with respect to one HC subject's MRI image using affine transformation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737348PMC
August 2019
2 Reads

The relationship between tumor aggressiveness and cholinergic PET imaging in prostate cancer tissue. A proof-of-concept study.

Am J Nucl Med Mol Imaging 2019 15;9(3):185-192. Epub 2019 Jun 15.

Department of Nuclear Medicine and PET, Aarhus University Hospital Aarhus, Denmark.

It was recently shown that high-risk prostate carcinoma (PCa) exhibited parasympathetic neurogenesis. The PET tracer C-donepezil is a marker of parasympathetic innervation. Therefore, we studied if parasympathetic nerve density in PCa measured with C-donepezil PET correlated with PCa aggressiveness and if metastases could be visualized. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627478PMC
June 2019
4 Reads

Dual-point FDG-PET/CT for treatment response assessment in Hodgkin lymphoma, when an FDG-avid lesion persists after treatment.

Am J Nucl Med Mol Imaging 2019 15;9(3):176-184. Epub 2019 Jun 15.

Research and Clinical, Innovation Department, A. Lacassagne Cancer Centre Nice, France.

FDG-PET/CT (PET) is now considered the standard imaging tool for Hodgkin Lymphoma (HL) staging and restaging. However a CT-detected residual mass at the end of therapy (EoT) is still a challenge for PET interpretation. The aim of our study was to improve the overall accuracy of EoT PET/CT by using a dynamic dual-point scanning at 60 and 120 after FDG injection (2P-PET/CT). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627477PMC
June 2019
1 Read

Evaluation of PET/CT in patients with stage III malignant cutaneous melanoma.

Am J Nucl Med Mol Imaging 2019 15;9(2):168-175. Epub 2019 Apr 15.

Department of Surgery, University Medical Center Utrecht NL, Netherlands.

In order to evaluate if patients with stage III-IV MCM are eligible for curative treatment PET/CT is performed. Since the diagnostic value of PET/CT is not unambiguously, a retrospective cohort study is performed to tailor optimal indication of PET/CT in patients with stage III MCM. A retrospective cohort study was conducted of all patients with stage III disease in a large oncologic teaching hospital in which PET/CT was performed from 2012 to 2016. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526367PMC
April 2019
3 Reads

Examining correlations of oxygen sensitive MRI (BOLD/TOLD) with [F]FMISO PET in rat prostate tumors.

Am J Nucl Med Mol Imaging 2019 15;9(2):156-167. Epub 2019 Apr 15.

Department of Radiology, UT Southwestern Medical Center Dallas, TX 75390-9058, USA.

Hypoxia is regarded as a potential prognostic biomarker for tumor aggressiveness, progression, and response to therapy. The radiotracer F-fluoromisonidazole ([F]FMISO) has been used with positron emission tomography (PET) to reveal tumor hypoxia. Meanwhile, blood oxygen level dependent (BOLD) MRI and tissue oxygen level dependent (TOLD) MRI offer insight into oxygenation based on endogenous signals without the need for radiolabels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526364PMC
April 2019
11 Reads

Quantitative applications in positron emission tomography achieved through signal modelling.

Am J Nucl Med Mol Imaging 2019 15;9(2):140-155. Epub 2019 Apr 15.

Department of Nuclear Medicine and PET Center, Aarhus University Hospital Aarhus, Denmark.

Positron emission tomography (PET) is a valuable tool in medical imaging, but it provides limited quantitative utility in a number of important applications, such as mapping of tracer accumulation in small tissues and quantitative assessment of factors affecting tracer uptake. We aimed to develop a quantification approach based on signal modelling, to address the above limitations. Our signal modelling approach allows for a comprehensive description of target and background signals. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526366PMC
April 2019
2 Reads

Radiolabelled choline versus PSMA PET/CT in prostate cancer restaging: a meta-analysis.

Am J Nucl Med Mol Imaging 2019 15;9(2):127-139. Epub 2019 Apr 15.

Clinic of Nuclear Medicine and Molecular Imaging, Imaging Institute of Southern Switzerland Bellinzona and Lugano, Switzerland.

Both radiolabelled choline and prostate specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) could be used in patients with biochemical recurrent prostate cancer (BRPCa). We aimed to perform a meta-analysis about the head-to-head comparison of detection rate (DR) between these methods in BRPCa. A comprehensive literature search of studies listed in PubMed/MEDLINE, EMBASE and Cochrane library databases through October 2018 and regarding the head-to-head comparison of DR between radiolabelled choline and PSMA PET/CT in BRPCa was carried out. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526363PMC
April 2019
7 Reads

Update on imaging-based diagnosis of acute renal allograft rejection.

Am J Nucl Med Mol Imaging 2019 15;9(2):110-126. Epub 2019 Apr 15.

Department of Medicine, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster 48149 Muenster, Germany.

Kidney transplantation is the preferred treatment for patients with end-stage renal disease. Despite effective immunosuppressants, acute allograft rejections pose a major threat to graft survival. In early stages, acute rejections are still potentially reversible, and early detection is crucial to initiate the necessary treatment options and to prevent further graft dysfunction or even loss of the complete graft. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526365PMC
April 2019
24 Reads

Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment.

Am J Nucl Med Mol Imaging 2019 15;9(1):93-109. Epub 2019 Feb 15.

Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation Oklahoma, OK, USA.

Glioblastomas (GBM) are deadly brain tumors that currently do not have long-term patient treatments available. GBM overexpress the angiogenesis factor VEGF and its receptor VEGFR2. ETLD1 (epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1), a G-protein coupled receptor (GPCR) protein, we discovered as a biomarker for high-grade gliomas, is also a novel regulator of angiogenesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420708PMC
February 2019
4 Reads

PET/DW-MRI for evaluating treatment in chronic hepatitis C patients.

Am J Nucl Med Mol Imaging 2019 15;9(1):84-92. Epub 2019 Feb 15.

Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen Denmark.

This feasibility study set out to investigate the use of FDG-PET/DW-MRI in chronic hepatitis C patients to examine changes in local liver inflammation after treatment with direct-acting antivirals (DAA). Twelve patients with chronic hepatitis C were prospectively enrolled, performing FDG-PET/DW-MRI prior to and after DAA treatment. PET/DW-MRI included PET acquisition 60 and 90 min after FDG-injection, DIXON, for attenuation correction, T2- and DW-MRI with 10 b-values between 0-700 s/mm. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420713PMC
February 2019
3 Reads

Ga[Ga]-, In[In]-oxine: a novel strategy of radiolabeling of HPMA-based micelles.

Am J Nucl Med Mol Imaging 2019 15;9(1):67-83. Epub 2019 Feb 15.

Institute of Nuclear Chemistry, Johannes Gutenberg-University Fritz-Straßmann-Weg 2, Mainz 55128, Germany.

Polymeric micelles are of increasing interest as drug delivery vehicles since they can accumulate in tumor tissue through EPR effect and deliver their hydrophobic cargo. The pharmacology can be visualized and quantified noninvasively by molecular imaging techniques. Here, a novel, fast and efficient technique for radiolabeling various HPMA-LMA based micellar aggregates with hydrophobic oxine-complexes of the trivalent radiometals Ga and In was investigated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420711PMC
February 2019
2 Reads

Radionuclide generators: the prospect of availing PET radiotracers to meet current clinical needs and future research demands.

Am J Nucl Med Mol Imaging 2019 15;9(1):30-66. Epub 2019 Feb 15.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre Trombay, Mumbai 400085, India.

Targeted molecular imaging with positron emission tomography (PET) constitutes a successful technique for detecting and diagnosing disease conditions promptly and accurately, and for effectively prognosticating outcomes and treating patients with a tailored and more individualized intervention. In order to expand the success of PET in nuclear medicine, it is important to assure access to radiotracers of desired quantities and qualities. In this context, the benefit of accessing PET radiotracers through a radionuclide generator (RNG) cannot be overstated, as generators offer the potential of enriching the PET radiotracer arsenal at the medical centers both with and without onsite cyclotrons. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420712PMC
February 2019
4 Reads

Feasibility of rapid integrated radiation therapy planning with follow-up FDG PET/CT to improve overall treatment assessment in head and neck cancer.

Am J Nucl Med Mol Imaging 2019 15;9(1):24-29. Epub 2019 Feb 15.

Department of Radiation Oncology, University of Colorado School of Medicine Aurora, CO 80045, USA.

Inflammatory changes and residual disease are difficult to distinguish after high dose, definitive radiotherapy of head and neck malignancies. FDG uptake located within a high dose field may more likely represent inflammatory changes, and FDG uptake outside of the radiation field could represent unsuspected and under treated disease. In situ knowledge of the precise radiotherapy fields, therefore, may be useful in distinguishing these etiologies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420709PMC
February 2019
2 Reads

Diagnostic HER2-binding radiopharmaceutical, [Ga]Ga-ABY-025, for routine clinical use in breast cancer patients.

Am J Nucl Med Mol Imaging 2019 15;9(1):12-23. Epub 2019 Feb 15.

Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University Uppsala, Sweden.

[Ga]Ga-ABY-025/PET-CT targeting human epidermal growth factor receptor type 2 (HER2) has demonstrated its potential clinical value for the detection and quantification of HER2 in a phase I clinical study with breast cancer patients. Previously, the radiopharmaceutical was prepared manually, however larger scale of multicenter clinical trials and routine healthcare requires automation of the production process to limit the operator radiation dose, improve tracer manufacturing robustness, and provide on-line documentation for good manufacturing practice (GMP) compliance. The production of [Ga]Ga-ABY-025 was implemented on the Modular-Lab PharmTrace synthesis platform (Eckert & Ziegler) and disposable cassettes were developed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420710PMC
February 2019
22 Reads

Tissue volume and activity mapping using total intensity projection of PET/CT images.

Am J Nucl Med Mol Imaging 2019 15;9(1):1-11. Epub 2019 Feb 15.

Department of Nuclear Medicine and PET Center, Aarhus University Hospital Aarhus, Denmark.

Autoradiography using phosphor imaging screens is often used to characterize tissue distribution of positron emission tomography (PET) radiotracers. PET tracers emit positrons with limited penetration range, and valid quantitative autoradiography can therefore only be achieved in thin tissue slices. However, in some settings, quantitative tracer profiling in thick tissues is required. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420714PMC
February 2019
2 Reads

Preclinical PET tracers for the evaluation of sarcomas: understanding tumor biology.

Am J Nucl Med Mol Imaging 2018 20;8(6):428-440. Epub 2018 Dec 20.

Department of Radiology, University of Pennsylvania 3400 Spruce Street, Philadelphia, PA 19104, USA.

Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334210PMC
December 2018
2 Reads

FDG PET imaging in multiple myeloma: implications for response assessments in clinical trials.

Am J Nucl Med Mol Imaging 2018 20;8(6):421-427. Epub 2018 Dec 20.

University Hospitals, Case Comprehensive Cancer Center, Case Western Reserve University Cleveland, OH, USA.

F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (F-FDG PET/CT) is an effective modality to assess disease burden, detect extra-medullary disease and monitor minimal residual disease (MRD) for multiple myeloma (MM) patients. This modality of imaging is incorporated in the International Myeloma Working Group (IMWG) response criteria that are widely used in MM clinical trials. Interpretative pitfalls are commonly encountered in F-FDG PET/CT studies and proper interpretation requires knowledge of the normal physiologic distribution of the tracer affecting available F-FDG for tumor tissue uptake. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334211PMC
December 2018
27 Reads

Utility of metabolic heterogeneity factor in differentiating malignant versus benign parotid uptake on F FDG PET-CT.

Am J Nucl Med Mol Imaging 2018 20;8(6):415-420. Epub 2018 Dec 20.

Department of Nuclear Medicine and PET, John Hunter and Calvary Mater Hospitals Newcastle NSW, Australia.

Differentiation of benign and malignant parotid uptake on Fluorine 18 Fluro-Deoxy-Glucose Positron Emission Tomography-Computed Tomography (F FDG PET-CT) is of paramount importance due to the poor prognosis of the later but usual quantitative measures such as standardized uptake value (SUV) are not reliable for this purpose. Metabolic heterogeneity, being a characteristic of malignant tumors, would potentially be able to make this distinction. In this study, seventy-one FDG-avid parotid lesions were retrospectively separated histologically into benign and malignant groups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334206PMC
December 2018
2 Reads

Pre-treatment partial-volume-corrected TLG is the best predictor of overall survival in patients with relapsing/refractory non-hodgkin lymphoma following radioimmunotherapy.

Am J Nucl Med Mol Imaging 2018 20;8(6):407-414. Epub 2018 Dec 20.

Department of Radiology, Hospital of The University of Pennsylvania PA, USA.

The role of fluorodeoxyglucose-positron emission tomography (FDG-PET) has been well established in assessment of lymphoma, including non-Hodgkin lymphoma (NHL). The aim of this study was to compare changes and survival predictive values of various quantification parameters of FDG-PET/CT in patients with relapsing/refractory lymphoma before and after radioimmunotherapy (RIT). Data from 17 patients with relapsing/refractory NHL, treated with targeted RIT after chemotherapy/radiotherapy, were retrospectively collected. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334213PMC
December 2018
50 Reads

Evaluation of planar bioluminescence imaging and microPET/CT for therapy monitoring in a mouse model of pigmented metastatic melanoma.

Am J Nucl Med Mol Imaging 2018 20;8(6):397-406. Epub 2018 Dec 20.

Unité Claude Kellershohn, Institut Universitaire d'Hématologie, Hôpital St-Louis Paris, France.

Bioluminescence imaging (BLI) is widely used for monitoring of anti-cancer therapy in mice. [F]MEL050 is a Positron Emission Tomography (PET) radiotracer which specifically targets melanin. We evaluated planar BLI and [F]MEL050-PET/CT for therapy (pro-apoptotic peptide LZDP) monitoring in a mouse model of metastatic pigmented melanoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334212PMC
December 2018
4 Reads

Metabolic and densitometric correlation between atherosclerotic plaque and trabecular bone: an F-Natrium-Fluoride PET/CT study.

Am J Nucl Med Mol Imaging 2018 20;8(6):387-396. Epub 2018 Dec 20.

Nuclear Medicine Unit, Department of Health Sciences, University of Genoa Italy.

Increasing evidence links atherosclerosis to a decreased bone thickness. This correlation could reflect a bone/plaque interaction. Hereby we analyzed Hounsfield density (HU) and mineral turnover in bone and in the arterial calcifications (AC), using a computational method applied to PET/CT data. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334207PMC
December 2018
5 Reads

Multi-level otsu method to define metabolic tumor volume in positron emission tomography.

Am J Nucl Med Mol Imaging 2018 20;8(6):373-386. Epub 2018 Dec 20.

Radiology, University of Wisconsin Madison, WI, USA.

This study was to validate reliability and clinical utility of a PET tumor segmentation method using multi-level Otsu (MO-PET) in standard National Electrical Manufacturers Association (NEMA) image quality (IQ) phantom and patients with osteosarcoma. The NEMA IQ phantom was prepared with a lesion-to-background ratio (LBR) of either 8:1, 4:1, or 1.5:1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334209PMC
December 2018
19 Reads

Early perfusion and dopamine transporter imaging using F-FP-CIT PET/CT in patients with parkinsonism.

Am J Nucl Med Mol Imaging 2018 20;8(6):360-372. Epub 2018 Dec 20.

Department of Nuclear Medicine, Kyungpook National University Hospital Daegu, Republic of Korea.

Combined use of F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost. In this review, we summarize the advantages of using F-FP-CIT PET for perfusion and dopamine transporter imaging, as well as clinical features useful for the differential diagnosis of PD and Parkinson plus syndrome. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334208PMC
December 2018
7 Reads

Ga-PSMA-11 PET/CT in prostate cancer local recurrence: impact of early images and parametric analysis.

Am J Nucl Med Mol Imaging 2018 20;8(5):351-359. Epub 2018 Oct 20.

Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ) Heidelberg, Germany.

Ga-PSMA-11 PET/CT performed 60 min post tracer injection (p.i.) can underestimate prostate cancer (PC) local recurrence, due to high Ga-PSMA-11 urinary bladder accumulation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261880PMC
October 2018
6 Reads

Usefulness of positron emission mammography in the evaluation of response to neoadjuvant chemotherapy in patients with breast cancer.

Am J Nucl Med Mol Imaging 2018 20;8(5):341-350. Epub 2018 Oct 20.

Human Health Department International Atomic Energy Agency (IAEA).

Our study examines the association between two Positron Emission Mammography (PEM) semi-quantitative parameters: PUVmax (maximum uptake value) and LTB (lesion to background) baseline and the end of Neoadjuvant chemotherapy (NAC) with pathologic response in each of the following breast cancer subtype: Triple negative breast cancer (TPN), HER2-positive, and ER-positive/HER2-negative cancers. One-hundred and eight patients, 71 with invasive ductal carcinoma and 37 with infiltrating lobular carcinoma were evaluate with F-FDG-PEM scans before and after of NAC. We assessed the impact of 2 PEM semi-quantitative parameters for molecular subtype correlated with pathologic response according Miller-Payne grade (MPG). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261879PMC
October 2018
5 Reads

Head to head comparison performance of Tc-EDDA/HYNIC-iPSMA SPECT/CT and Ga-PSMA-11 PET/CT a prospective study in biochemical recurrence prostate cancer patients.

Am J Nucl Med Mol Imaging 2018 20;8(5):332-340. Epub 2018 Oct 20.

Nuclear Medicine and Department of Molecular Imaging, Instituto Nacional de Cancerología Mexico City, Mexico.

Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) has found widespread use for the diagnosis of biochemical recurrence of prostate cancer (PCa). Unfortunately, PET/CT is not as widely available; thus a PSMA-targeting compound for scintigraphy is of special interest. The aim of this study was to compare Tc-EDDA/HYNIC-iPSMA and Ga-PSMA-11 PET/CT qualitatively and semi-quantitatively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261875PMC
October 2018
35 Reads

Somatostatin receptor PET ligands - the next generation for clinical practice.

Am J Nucl Med Mol Imaging 2018 20;8(5):311-331. Epub 2018 Oct 20.

Nuclear Medicine, University Hospitals Leuven Leuven, Belgium.

Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be exploited for molecular imaging and for peptide receptor radionuclide therapy. In-DTPA-octreotide has long been the standard in SSTR scintigraphy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261874PMC
October 2018
3 Reads

Chemotherapy-induced coronary arteries calcium score deterioration as detected with unenhanced CT portion of FDG PET/CT.

Am J Nucl Med Mol Imaging 2018 20;8(5):303-310. Epub 2018 Oct 20.

Division of Nuclear Medicine, Department of Radiology, Saint Louis University 3635 Vista Ave, Saint Louis, MO 63110, USA.

This study aims to detect the potential impact of chemotherapy on the coronary calcium scoring (CCS) in lymphoma patients undergoing FDG-PET/CT at baseline and for therapy response using the CT portion of the exam to calculate the CCS. One hundred twelve lymphoma patients were included in the study based on having both baseline and at least 2 post-chemotherapy scans. The unenhanced CT portions of the scans were reviewed to measure the CCS which was then extracted using the Toshiba Vital Program. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261876PMC
October 2018
37 Reads