1,480 results match your criteria Am J Cancer Res[Journal]


Erratum: Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism.

Am J Cancer Res 2020 1;10(4):1277. Epub 2020 Apr 1.

Department of Immunology, School of Medicine, Yangzhou University Yangzhou 225001, P. R. China.

[This corrects the article on p. 595 in vol. 10, PMID: 32195030. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191092PMC
April 2020
3.968 Impact Factor

Erratum: PTTG promotes invasion in human breast cancer cell line by upregulating EMMPRIN via FAK/Akt/mTOR signaling.

Am J Cancer Res 2020 1;10(4):1274-1276. Epub 2020 Apr 1.

Qingdao University Qingdao 266071, Shandong, China.

[This corrects the article on p. 425 in vol. 6, PMID: 27186413. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191105PMC
April 2020
3.968 Impact Factor

Erratum: Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells.

Am J Cancer Res 2020 1;10(4):1271-1273. Epub 2020 Apr 1.

Medical College, Qingdao University Qingdao 266071, Shandong, China.

[This corrects the article on p. 1047 in vol. 5, PMID: 26045985. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191100PMC
April 2020
3.968 Impact Factor

Interferon regulatory factor-1 suppresses DNA damage response and reverses chemotherapy resistance by downregulating the expression of RAD51 in gastric cancer.

Am J Cancer Res 2020 1;10(4):1255-1270. Epub 2020 Apr 1.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, Hubei, P. R. China.

Recent studies have shown that IRF-1 plays a significant role in various tumour-induced chemoresistance, but its role and mechanism in gastric cancer-associated chemoresistance are not clear. Our study showed that IRF-1 expression could reverse gastric cancer-related chemoresistance. Dysregulated DNA repair is an important cause of chemoresistance. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191096PMC

SH3BGRL2 exerts a dual function in breast cancer growth and metastasis and is regulated by TGF-β1.

Am J Cancer Res 2020 1;10(4):1238-1254. Epub 2020 Apr 1.

Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University Shanghai 200032, China.

SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2) is a poorly defined member of the SH3BGR gene family with potential roles in cell differentiation and tissue development. Here, we report for the first time that SH3BGRL2 exerts a dual function in breast tumor growth and metastasis. SH3BGRL2 was downregulated in a subset of primary breast tumors, and suppressed breast cancer cell proliferation and colony formation and xenograft tumor growth . Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191107PMC

Cisplatin sensitivity mediated by NKX2-1 in lung adenocarcinoma is dependent on p53 mutational status via modulating TNFSF10 expression.

Am J Cancer Res 2020 1;10(4):1229-1237. Epub 2020 Apr 1.

Graduate Institute of Cancer Biology and Drug Discovery, Taipei Medical University Taipei, Taiwan.

NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma cells. However, NKX2-1 as a dual role in tumor progression depended on p53 mutational status via modulation of the NF-κB pathway. We hypothesized that NKX2-1 may confer cisplatin resistance in p53-mutated (p53-MT) lung adenocarcinoma cells but may enhance cisplatin sensitivity in wild-type (p53-WT) cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191106PMC

Pre-transplant cytoreductive therapy can improve overall survival of patients with MDS-AML but not MDS-EB2 receiving HLA-matched sibling donor peripheral blood stem cell transplantation.

Am J Cancer Res 2020 1;10(4):1218-1228. Epub 2020 Apr 1.

Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin, China.

To evaluate whether cytoreductive therapy is needed for myelodysplastic syndromes (MDS) patients with excess blasts type 2 (MDS-EB2) and acute myeloid leukemia derived from MDS (MDS-AML) before HLA-matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT), we retrospectively analyzed 80 cases of MDS-EB2 and MDS-AML patients who received MSD-PBSCT between February 2006 and December 2019 in our hospital. The 3-years overall survival (OS) rate and disease-free survival (DFS) rate were (59.1±5. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191098PMC
April 2020
3.968 Impact Factor

Verteporfin induced SUMOylation of YAP1 in endometrial cancer.

Am J Cancer Res 2020 1;10(4):1207-1217. Epub 2020 Apr 1.

Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University Shanghai, People's Republic of China.

Yes-associated protein (YAP or YAP1) has been proposed to function as an oncogene in most cancers, with nuclear localization of YAP1 correlating with poor prognosis. Photosensitizer Verteporfin has been proven as an inhibitor of YAP1 through preventing the combination of YAP1 with TEA domain transcription factor (TEAD). We showed previously that the total and phospho-levels of YAP1 were related to the clinical characteristics and outcomes in endometrial cancer (EC) patients, and that YAP1 promoted the proliferation and metastasis of EC cells in vitro cell line studies and in animal models. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191103PMC

Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma.

Am J Cancer Res 2020 1;10(4):1194-1206. Epub 2020 Apr 1.

Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, and Center for Molecular Medicine, China Medical University Taichung 404, Taiwan.

The cyclin-dependent kinase 2 (CDK2) inhibitor dinaciclib, a potential anti-cancer drug, has been tested in clinical trials and reported to suppress tumor initiating cells. Our recent study demonstrated that pharmacological inhibition of CDK2 or enhancer of zeste homolog 2 (EZH2) allows re-expression of ERα and converts triple-negative breast cancers (TNBC) to luminal ERα-positive, rendering TNBC cells targetable by tamoxifen. Like TNBC, EZH2 is also commonly overexpressed in ovarian cancers, and overexpression of cyclin E1 gene (CCNE1) and/or amplification of its associated kinase gene is present in ovarian tumor specimens, both of which are associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191104PMC

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.

Am J Cancer Res 2020 1;10(4):1182-1193. Epub 2020 Apr 1.

Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center Shanghai, China.

ADP Ribosylation Factor 6 (ARF6) is a part of the RAS superfamily and regulates vesicular trafficking, remodeling of membrane lipids, and signaling pathways. Our previous study has found that ARF6, functioned as a downstream of Kras/ERK signaling pathway, could promote proliferation and Warburg effect in pancreatic cancer cells. Moreover, ARF6 is promising to be a biomarker for predicting prognosis of pancreatic cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191101PMC

V3 ameliorates colitis-associated tumorigenesis by modulating the gut microbiome.

Am J Cancer Res 2020 1;10(4):1170-1181. Epub 2020 Apr 1.

Institute of Food Science and Technology, National Taiwan University Taipei 10617, Taiwan.

spp., a common probiotic used as a dietary supplement, is good for the digestive system. However, its anti-cancer activity still remains unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191089PMC

USP18 deubiquitinates and stabilizes Twist1 to promote epithelial-mesenchymal transition in glioblastoma cells.

Am J Cancer Res 2020 1;10(4):1156-1169. Epub 2020 Apr 1.

Department of Neurosurgery, The 904th Hospital of People's Liberation Army (PLA), Clinical Medical College of Anhui Medical University Wuxi, Jiangsu, China.

Aberrant activation of epithelial-mesenchymal transition (EMT) pathway drives the invasion and migration of multiple cancers including glioblastoma (GBM). Clinical interventions focused on inhibiting EMT are of increasing interest in the treatment of GBM. In the present study, we discovered that glioma tissues and cells, especially GBMs show significantly up-modulated ubiquitin-specific protease 18 (USP18) expression. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191102PMC

CDK9 inhibitor CDKI-73 is synergetic lethal with PARP inhibitor olaparib in BRCA1 wide-type ovarian cancer.

Am J Cancer Res 2020 1;10(4):1140-1155. Epub 2020 Apr 1.

Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University Shanghai 200011, China.

Poly (adenosine diphosphate ribose) polymerase (PARP) inhibitors benefit a small percentage of ovarian cancer patients with homologous recombination (HR) deficiency (HRD), which greatly limits the applications of PARP inhibitors. Given the function of CDK9 in homologous recombination repair (HRR), here, we show how to extend the utility of PARP inhibitors in BRCA1-proficient ovarian cancer by targeting CDK9. We found that high CDK9 expression is associated with a higher tumor stage in epithelial ovarian cancer patients, and CDK9 is co-expressed with BRCA1 by analyzing a public database. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191097PMC
April 2020
3.968 Impact Factor

Circular RNA circEIF3I promotes papillary thyroid carcinoma progression through competitively binding to miR-149 and upregulating KIF2A expression.

Am J Cancer Res 2020 1;10(4):1130-1139. Epub 2020 Apr 1.

Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.

Circular RNAs (circRNAs) have been shown to regulate the development and progression of various cancers. However, the expression and function of circRNAs in papillary thyroid cancer (PTC) remain largely unknown. This study is aimed to investigate the potential roles of circEIF3I in PTC and elucidate the functional mechanism. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191093PMC

miR-216a-mediated upregulation of TSPAN1 contributes to pancreatic cancer progression via transcriptional regulation of ITGA2.

Am J Cancer Res 2020 1;10(4):1115-1129. Epub 2020 Apr 1.

College of Life Science and Bioengineering, Beijing University of Technology Beijing 100124, China.

Pancreatic cancer (PC) is recognized as the most aggressive and deadliest malignancy because it has the highest mortality of all cancers in humans. Mutations in multiple tumor suppressors and oncogenes have been documented to be involved in pancreatic cancer progression and metastasis. The upregulation of tetraspanin 1 (TSPAN1), a transmembrane protein, has been reportedly observed in many human cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191091PMC

BRAF in malignant melanoma progression and metastasis: potentials and challenges.

Am J Cancer Res 2020 1;10(4):1103-1114. Epub 2020 Apr 1.

Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University Makkah, Saudi Arabia.

Recent advances in gene sequencing have shown that activated BRAF mutations are present in more than 50% of malignant melanomas and contribute to constitutive signals in the MAPK pathway. Besides the importance of its mutations in cell proliferation, BRAF is associated with lymph node, brain and liver metastasis, along with the loss of PTEN expression and ATG5. Knowledge of this genetic alteration has led to the development of personalized and targeted therapy strategies which block different pathways driving melanoma pathogenesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191094PMC
April 2020
3.968 Impact Factor

Heterogeneous responses in hepatocellular carcinoma: the achilles heel of immune checkpoint inhibitors.

Am J Cancer Res 2020 1;10(4):1085-1102. Epub 2020 Apr 1.

Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou 310003, China.

Treatment of patients with hepatocellular carcinoma (HCC) remains a serious challenge due to high heterogeneity and limited treatment options. In the past few decades, immune therapy, especially immune checkpoint therapy, has become an alternative option for the treatment of malignancies including HCC. Immune checkpoint inhibitors (ICIs) have raised attention because of their significant antitumor effect and low toxicity. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191099PMC

The roles and mechanisms of YTH domain-containing proteins in cancer development and progression.

Am J Cancer Res 2020 1;10(4):1068-1084. Epub 2020 Apr 1.

Holistic Integrative Pharmacy Institutes, School of Medicine, Hangzhou Normal University Hangzhou, Zhejiang, China.

Evolutionarily conserved YT521-B homology (YTH) domain-containing proteins, including YTHDF1-3 and YTHDC1-2, are known to confer mA-dependent RNA-binding activity. The YTH domain-containing proteins participate in numerous RNA processes, such as mRNA splicing, nuclear export, translation and decay in post-transcriptional regulation. Most recently, it has been found that YTH domain-containing proteins play important roles in post-transcriptional modification process hence modulate the expression of genes involved in cancer and other processes including cell cycle progression, cell proliferation, migration and invasion, inflammatory, immunity and autophagy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191095PMC

The trastuzumab era: current and upcoming targeted HER2+ breast cancer therapies.

Am J Cancer Res 2020 1;10(4):1045-1067. Epub 2020 Apr 1.

Translation Oncology Laboratory, Avera Cancer Institute Sioux Falls, SD 57105, USA.

Human Epidermal Growth Factor Receptor 2-positive breast cancer (HER2+ BC) is defined by increased amplification of the oncogene and/or overexpression of its associated HER2 transmembrane receptor protein. HER2+ BC represents approximately 15-20% of breast cancer, and it is independently associated with a higher grade, more aggressive phenotype, and worse prognosis. With the advent of trastuzumab, the prognostic landscape for HER2+ BC patients has considerably improved. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191090PMC

LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.

Am J Cancer Res 2020 1;10(3):1026-1044. Epub 2020 Mar 1.

Department of Medical Oncology, The First Hospital of China Medical University Shenyang 110001, China.

Gastric cancer (GC) is one of the most common malignancies which has high incidence and mortality worldwide. Peritoneal dissemination is the main route of metastasis in advanced GC. However, few reliable diagnostic or prognostic biomarkers are available for peritoneal metastasis of GC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136906PMC
March 2020
3.968 Impact Factor

METTL3 enhances cell adhesion through stabilizing integrin β1 mRNA via an m6A-HuR-dependent mechanism in prostatic carcinoma.

Am J Cancer Res 2020 1;10(3):1012-1025. Epub 2020 Mar 1.

Department of Urology, The First Affiliated Hospital of University of South China Hengyang, Hunan, China.

Bone metastasis is the major cause of morbidity and mortality in patients with prostate cancer (PCa). However, the underlying mechanism of bone-specific metastasis remain vague. Recently, with the deep research of N6-methyladenine (m6A) mRNA methylation, many studies directly focus on the role of m6A modification in human diseases, especially in cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136910PMC

SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer.

Am J Cancer Res 2020 1;10(3):997-1011. Epub 2020 Mar 1.

Department of General Surgery, Affiliated Hospital of Xuzhou Medical University Xuzhou 221000, China.

Cancer metastasis is a significant challenge in colorectal cancer (CRC) therapy. SET and MYND domain-containing protein 2 (SMYD2) is highly expressed in multiple cancers but is rarely studied in CRC. This study aims to identify whether abnormal expression of SMYD2 is associated with cancer metastasis in CRC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136915PMC
March 2020
3.968 Impact Factor

Safety and effectiveness of apatinib in patients with previously treated metastatic gastric cancer: a sub-analysis from the real-world study of apatinib for gastric cancer treatment (AHEAD-G202).

Am J Cancer Res 2020 1;10(3):987-996. Epub 2020 Mar 1.

Department of Biotherapy, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.

Apatinib, a VEGFR2 receptor tyrosine kinase inhibitor, showed survival benefits in Asian patients with heavily pretreated advanced gastric cancer. However, the adverse event (AEs) profile of apatinib has limited its use. Dosing schedules are used to alleviate toxicities despite no supportive evidence. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136926PMC

The association and joint effect of serum cholesterol, glycemic status with the risk of incident cancer among middle-aged and elderly population in china cardiometabolic disease and cancer cohort (4C)-study.

Am J Cancer Res 2020 1;10(3):975-986. Epub 2020 Mar 1.

The State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine Shanghai, China.

The associations between different combinations of metabolic abnormalities and the risk of all and site-specific cancers remain unclear. We aimed to estimate the association and interplay between serum cholesterol, glycemic status and risk of cancer in the China Cardiometabolic Disease and Cancer Cohort (4C)-Study, a nationwide, multicenter, prospective, population-based study. The investigation was performed in 137,884 participants during 2014-2016. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136907PMC
March 2020
3.968 Impact Factor

MicroRNA-590-3p inhibits invasion and metastasis in triple-negative breast cancer by targeting Slug.

Am J Cancer Res 2020 1;10(3):965-974. Epub 2020 Mar 1.

Department of Breast Surgery, Harbin Medical University Cancer Hospital Harbin 150000, China.

miR-590-3p acts as a tumor suppressor in glioblastoma multiform, medulloblastoma, hepatocellular carcinoma, and nephroblastoma. Here, we studied the role of miR-590-3p in triple-negative breast cancer (TNBC). The miR-590-3p levels in TNBC specimens were significantly lower than those in non-TNBC specimens. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136920PMC

Neddylation inhibitor, MLN4924 suppresses angiogenesis in huvecs and solid cancers: and study.

Am J Cancer Res 2020 1;10(3):953-964. Epub 2020 Mar 1.

Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University Taipei 100, Taiwan.

Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate important biological processes and are a potential therapeutic target in many types of cancer. MLN4924, a small molecule of NEDD8-activating enzyme inhibitor, inactivates CRL by blocking cullin neddylation and has been reported to elicit anti-tumor effect. In this study, In this study, we aimed to investigate the effects of MLN4924 on angiogenesis in human umbilical vascular endothelial cells (HUVECs) and four types of cancer cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136913PMC

Ligustrazine reverts anthracycline chemotherapy resistance of human breast cancer by inhibiting JAK2/STAT3 signaling and decreasing fibrinogen gamma chain (FGG) expression.

Am J Cancer Res 2020 1;10(3):939-952. Epub 2020 Mar 1.

Department of Oncology, 960 Hospital of PLA Jinan 250031, China.

Chemotherapy resistance is a major challenge for breast cancer treatment. It is necessary to elucidate the mechanisms of anthracycline resistance to develop new chemosensitizers for breast cancer. In this study, we explored the effects of ligustrazine (TMP) on reverting anthracycline resistance of breast cancer cells, as well as its related mechanisms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136924PMC

N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex.

Am J Cancer Res 2020 1;10(3):925-938. Epub 2020 Mar 1.

Central Laboratory, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute Shenyang 110042, Liaoning, China.

The N-terminal truncated carboxypeptidase E (CPEΔN) protein, an alternative splicing product of the carboxypeptidase E gene, has recently been recognized as an independent predictor for the recurrence and metastasis of lung adenocarcinoma. In this study, we showed that CPEΔN may accelerate lung cancer invasion via an E-cadherin-dependent mechanism. experiments and bioluminescence imaging assay revealed CPEΔN promoted the mobility and invasion of human lung cancer cells by suppressing endogenous expression of E-cadherin, a critical regulator for epithelial tissue homeostasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136916PMC
March 2020
3.968 Impact Factor

mTOR inhibition overcomes primary and acquired resistance to Wee1 inhibition by augmenting replication stress in epithelial ovarian cancers.

Am J Cancer Res 2020 1;10(3):908-924. Epub 2020 Mar 1.

Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, Hubei, P. R. China.

Epithelial ovarian cancer is characterized by universal TP53 mutations, which result in G1/S checkpoint deficiencies. Therefore, it is hypothesized that the abrogation of the G2/M checkpoint with Wee1 inhibitor might preferentially sensitize TP53-defective ovarian cancer cells. Given the extremely high molecular diversity in ovarian cancer, one approach to improving the clinical efficacy is to identify drug combinations that either broaden the applicable spectrum or circumvent resistance. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136919PMC
March 2020
3.968 Impact Factor

KRAS signaling enriched triple negative breast cancer is associated with favorable tumor immune microenvironment and better survival.

Am J Cancer Res 2020 1;10(3):897-907. Epub 2020 Mar 1.

Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY 14263, USA.

KRAS signaling is associated with cancer progression in several cancers. Upregulation of KRAS signaling is often seen in cancers that harbor high KRAS mutation rate, such as pancreatic cancer and non-small cell lung cancer (NSCLC). Less than 2% of breast cancers have KRAS mutation, however, the alteration of the effector signaling such as PI3K/AKT and MAPK pathways are well known. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136911PMC
March 2020
3.968 Impact Factor

ROCK2 disturbs MKP1 expression to promote invasion and metastasis in hepatocellular carcinoma.

Am J Cancer Res 2020 1;10(3):884-896. Epub 2020 Mar 1.

Department of Gastrointestinal Surgery, Jiangxi Provincial Cancer Hospital Nanchang, Jiangxi Province, China.

Dual-specificity phosphatase-1 (DUSP1/MKP1) plays a key role in controlling various physiological and pathological phenomena, including tumor metastasis and invasion. However, the role of MKP1 in tumorigenesis is controversial. We showed that the expression of MKP1 in hepatocellular carcinoma (HCC) is significantly downregulated, and MKP1 is an independent predictor of poor prognosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136912PMC

Gossypol induces apoptosis of multiple myeloma cells through the JUN-JNK pathway.

Am J Cancer Res 2020 1;10(3):870-883. Epub 2020 Mar 1.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University Changsha 410078, Hunan, China.

Multiple myeloma (MM) is one of the most common hematologic neoplastic diseases. Gossypol was once used as a male contraceptive but is considered a novel antitumor agent. This study aimed to reveal the gossypol-induced apoptosis mechanism and its hub genes. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136925PMC

Polo-like kinase 1 as a therapeutic target for malignant peripheral nerve sheath tumors (MPNST) and schwannomas.

Am J Cancer Res 2020 1;10(3):856-869. Epub 2020 Mar 1.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA 19104, USA.

Neurofibromatosis type 1 (NF1) and Neurofibromatosis type 2 (NF2) are two dominantly inherited disorders that cause tumors in Schwann cells. NF1 patients have a high risk for malignant peripheral nerve sheath tumors (MPNST), which are often inoperable and do not respond well to current chemotherapies or radiation. NF2 patients have a high risk for schwannomas. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136923PMC
March 2020
3.968 Impact Factor

Endoplasmic reticulum stress confers 5-fluorouracil resistance in breast cancer cell the GRP78/OCT4/lncRNA MIAT/AKT pathway.

Am J Cancer Res 2020 1;10(3):838-855. Epub 2020 Mar 1.

Department of Thoracic Surgery, Renmin Hospital of Wuhan University Wuhan 430060, P. R. China.

5-Fluorouracil (5-FU) is an effective anticancer drug. However, high drug resistance limits its chemotherapeutic efficacy. Cancer cell resistance in colon cancer to 5-FU has been attributed to endoplasmic reticulum (ER) stress. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136914PMC

α1,6-Fucosyltransferase (FUT8) regulates the cancer-promoting capacity of cancer-associated fibroblasts (CAFs) by modifying EGFR core fucosylation (CF) in non-small cell lung cancer (NSCLC).

Am J Cancer Res 2020 1;10(3):816-837. Epub 2020 Mar 1.

The First Affiliated Hospital, Dalian Medical University Dalian, China.

Cancer-associated fibroblasts (CAFs) are the main cancer-promoting component in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). α1,6-Fucosyltransferase (FUT8), the key enzyme catalyzing core α1,6-fucosylation (CF), plays a promoting role in multiple malignancies. In the current study, we investigated the function of FUT8 in CAFs and elucidated the mechanism through which FUT8 regulates the cancer-promoting capacity of CAFs in NSCLC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136908PMC

Synergistic antitumor effect of 5-fluorouracil and withaferin-A induces endoplasmic reticulum stress-mediated autophagy and apoptosis in colorectal cancer cells.

Am J Cancer Res 2020 1;10(3):799-815. Epub 2020 Mar 1.

Department of Cellular and Molecular Medicine, University of Arizona Tucson, Arizona, United States of America.

The development of chemo-resistance against 5-fluorouracil (5-FU) in tumor cells is one of the main debacles in colorectal cancer (CRC) patients. A recent combination of 5-FU with oxaliplatin or cetuximab drastically improves the survival rate in CRC patients; however, the toxicity issue cannot be evaded completely. Thus, searching for novel drug combinations with high specificity and low toxicity is seemingly important. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136917PMC
March 2020
3.968 Impact Factor

ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.

Am J Cancer Res 2020 1;10(3):781-798. Epub 2020 Mar 1.

Department of Orthopedics, Second Affiliated Hospital of Nanchang University Nanchang, Jiangxi Province, China.

Osteosarcoma is a common bone tumor, with a poor prognosis. New combinatorial therapies that sensitize anticancer drug-resistant osteosarcoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) are, therefore, required. The GTPase RhoA effector, Rho-associated coiled-coil forming protein kinase 2 (ROCK2), is well known for its roles in various types of cancer; however, its involvement osteosarcoma has not yet been scrutinized. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136927PMC

The systems of metastatic potential prediction in pheochromocytoma and paraganglioma.

Am J Cancer Res 2020 1;10(3):769-780. Epub 2020 Mar 1.

Department of Urology, Xiangya Hospital, Central South University NO. 87 Xiangya Road, Changsha 410008, Hunan, P. R. China.

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors that arising from the adrenal medulla or extra-adrenal autonomic ganglia. Traditionally, PPGL was classified as benign or malignant based on the presence of distant metastasis at the time of initial surgery. However, according to WHO 2017 Classification of Tumors of Endocrine Organs, all PPGL has metastatic potential. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136918PMC

A comprehensive review of the roles of E2F1 in colon cancer.

Am J Cancer Res 2020 1;10(3):757-768. Epub 2020 Mar 1.

Central Laboratory, The Municipal Affiliated Hospital of Xuzhou Medical University Xuzhou 221002, China.

E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 recognition site. The dissociation of E2F1 from retinoblastoma (Rb) protein recovers its transcriptional activity, which drives the cell cycle from the G1 to S phase. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136928PMC

Vaginal microbiomes and ovarian cancer: a review.

Am J Cancer Res 2020 1;10(3):743-756. Epub 2020 Mar 1.

Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University No. 87 Xiangya Road, Changsha, China.

The human microbiome, often termed as "the forgotten organ", is an aggregation of microorganisms and their genomes that forms a mutualistic complex with the host. Recent research has shown the symbiotic merits of a microbiome ecosystem and its crucial role in the hosts' physiological functions. Disruption of this symbiotic relationship is prone to cause a broad spectrum of ailments, including cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136922PMC

PD-1/PD-L1 pathway: current researches in cancer.

Am J Cancer Res 2020 1;10(3):727-742. Epub 2020 Mar 1.

Pathology Department of Dalian Medical University Liaoning 116044, China.

Cancer immunotherapy has been accompanied by promising results over the past few years. Programmed Cell Death Protein 1 (PD-1) plays a vital role in inhibiting immune responses and promoting self-tolerance through modulating the activity of T-cells, activating apoptosis of antigen-specific T cells and inhibiting apoptosis of regulatory T cells. Programmed Cell Death Ligand 1 (PD-L1) is a trans-membrane protein that is considered to be a co-inhibitory factor of the immune response, it can combine with PD-1 to reduce the proliferation of PD-1 positive cells, inhibit their cytokine secretion and induce apoptosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136921PMC

SPOP and cancer: a systematic review.

Am J Cancer Res 2020 1;10(3):704-726. Epub 2020 Mar 1.

Department of Biology, University of The Incarnate Word San Antonio, TX, USA.

The initiation and progression of cancer is dependent on the acquisition of mutations in oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key regulatory pathways. Though these mutations often occur in direct regulators of such pathways, some may confer tumorigenic potential by indirectly targeting several pathways congruently thereby exerting pleiotropic effects. In recent years, the tumor suppressor gene Speckle Type POZ Protein (SPOP) has gained a lot of attention as it has been found to be altered in a variety of different cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136909PMC

Overcome trastuzumab resistance of breast cancer using anti-HER2 chimeric antigen receptor T cells and PD1 blockade.

Am J Cancer Res 2020 1;10(2):688-703. Epub 2020 Feb 1.

Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University Wenzhou 325035, China.

Trastuzumab-resistance is still a major challenge in treating patients with HER2 positive breast cancer. In this study, we tried to overcome transtuzumab-resistance by examining the therapeutic efficacy of third generation anti-HER2 chimeric antigen receptor (CAR)-T cells alone and in combination with PD1 blockade against HER2 positive and trastuzumab-resistance breast cancer cells in vitro and xenograft model. The anti-HER2 CAR-T cells were generated by infecting CD3/CD28 activated peripheral blood mononuclear cells with lentivirus expressing third generation anti-HER2 CAR. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061754PMC
February 2020

GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas.

Am J Cancer Res 2020 1;10(2):674-687. Epub 2020 Feb 1.

Department of Molecular Genetics and Microbiology, University of Florida Gainesville, FL 32610, USA.

Since the prognosis for children with high-risk osteosarcoma (OS) remains suboptimal despite intensive multi-modality therapies, there is a clear and urgent need for the development of targeted therapeutics against these refractory malignancies. Chimeric antigen receptor (CAR) modified T cells can meet this need by utilizing the immune system's potent cytotoxic mechanisms against tumor specific antigen targets with exquisite specificity. Since OS highly expresses the GD2 antigen, a viable immunotherapeutic target, we sought to assess if CAR modified T cells targeting GD2 could induce cytotoxicity against OS tumor cells. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061749PMC
February 2020
3.968 Impact Factor

Type-2 11β-hydroxysteroid dehydrogenase promotes the metastasis of colorectal cancer via the Fgfbp1-AKT pathway.

Am J Cancer Res 2020 1;10(2):662-673. Epub 2020 Feb 1.

Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST) Wuhan, Hubei, P.R. China.

Type-2 11β-hydroxysteroid dehydrogenase (HSD11B2) is a key enzyme which converts cortisol to inactive cortisone and is involved in tumor progression and metastasis. Several studies have shown that the promotion of tumor progression and metastasis by HSD11B2 resulted from its physiological function of inactivating glucocorticoids (GC). However, the underlying molecular mechanisms by which HSD11B2 drives metastasis, in addition to inactivating GC, are still unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061758PMC
February 2020

Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer.

Am J Cancer Res 2020 1;10(2):648-661. Epub 2020 Feb 1.

Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology, Center for Molecular Medicine, China Medical University Taichung 404, Taiwan.

The limited treatment options and therapeutic failure due to acquired resistance for patients with triple-negative breast cancer (TNBC) represent a significant challenge. Inhibitors against poly (ADP-ribose) polymerase (PARP), olaparib and talazoparib, were recently approved for the treatment of metastatic breast cancer (including TNBC) in patients with germline mutations. Despite impressive response rates of ~60%, the prolongation in median progression-free survival with a PARPi is modest, suggesting the emergence of resistance. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061756PMC
February 2020

MIIP inhibits EMT and cell invasion in prostate cancer through miR-181a/b-5p-KLF17 axis.

Am J Cancer Res 2020 1;10(2):630-647. Epub 2020 Feb 1.

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University Xi'an 710032, Shaanxi, China.

Growing evidence have shown that the migration and invasion inhibitory protein (MIIP, also known as IIp45) functions as a tumor suppressor and its expression is downregulated in several types of cancer, yet the function of MIIP in prostate cancer (PCa) and the underlying mechanism of action remains largely unknown. Here we demonstrated that MIIP acts as a suppressor of PCa by inhibiting epithelial-mesenchymal transition (EMT) and cell invasion. Overexpressing MIIP repressed cellular invasion of PC3 and DU145 in vitro, accompanied by a decrease of EMT-inducing factors, and an increase of E-cadherin and KLF17. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061746PMC
February 2020

The HIPPO pathway in gynecological malignancies.

Am J Cancer Res 2020 1;10(2):610-629. Epub 2020 Feb 1.

Department of Obstetrics and Gynecology, Second Hospital of Jilin University Changchun, Jilin, P. R. China.

The Hippo pathway has been initially discovered by screening genes that regulate organ size in . Recent studies have highlighted the role of the Hippo pathway in controlling organ size, tissue homeostasis and regeneration, and signaling dysregulation, especially the overactivation of the transcriptional coactivator YAP/TAZ, which leads to uncontrolled cell growth and malignant transformation. The core components of the Hippo pathway may initiate tumorigenesis by inducing tumor stem cells and proliferation, ultimately leading to metastasis and drug resistance, which occurs extensively in gynecological malignancies, including cervical cancer, ovarian cancer, and endometrial cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061741PMC
February 2020

Angiopoietin-like 4 deficiency upregulates macrophage function through the dysregulation of cell-intrinsic fatty acid metabolism.

Am J Cancer Res 2020 1;10(2):595-609. Epub 2020 Feb 1.

Department of Immunology, School of Medicine, Yangzhou University Yangzhou 225001, P. R. China.

Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macrophages produce large amounts of TNF-α, CD86, and inducible nitric oxide synthase. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061760PMC
February 2020
3.968 Impact Factor

Potent and broad anticancer activities of leaf extracts from L. of the subtropical Okinawa islands.

Am J Cancer Res 2020 1;10(2):581-594. Epub 2020 Feb 1.

Cell Signal Unit, Okinawa Institute of Science and Technology Graduate University Onna, Okinawa 904-0495, Japan.

Plant extracts have been traditionally used for various therapeutic applications. By conducting an initial screening of several subtropical plants, in this study, we evaluated the anticancer activities of . The extract from . Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061759PMC
February 2020