J Neuropathol Exp Neurol 2021 May 15. Epub 2021 May 15.
From the Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts (JRD, HY, BTH); Harvard Medical School, Boston, Massachusetts (JRD, HY, MPF, BTH); C.S. Kubik Laboratory for Neuropathology, Department of Pathology, and Neurology Service, Massachusetts General Hospital, Boston, Massachusetts (MPF).
Abnormal protein accumulation and mislocalization is a general hallmark of Alzheimer disease. Recent data suggest nucleocytoplasmic transport may be compromised by tau in Alzheimer disease. In this context, we have examined the RNA polymerase II subunit RPB1, which is the catalytic subunit that plays a critical role in transcription. Read More