1,881 results match your criteria Alzheimer disease and associated disorders[Journal]


Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy.

Alzheimer Dis Assoc Disord 2020 May 22. Epub 2020 May 22.

Rush Alzheimer's Disease Center.

Purpose: Emerging evidence suggests that limbic-predominant age-related TAR DNA-binding protein-43 (TDP-43) encephalopathy impacts domain-specific literacy, a complex ability not assessed in traditional cognitive evaluations. We examined longitudinal profiles of financial and health literacy in relation to limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC).

Participants: A total of 275 community-dwelling older persons who had completed annual literacy assessments, died and undergone brain autopsy. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000389DOI Listing

Association Between Cognitive Test Performance and Subjective Cognitive Decline in a Diverse Cohort of Older Adults: Findings From the KHANDLE Study.

Alzheimer Dis Assoc Disord 2020 May 15. Epub 2020 May 15.

Department of Epidemiology.

Background: Subjective cognitive decline (SCD) may represent a low-burden indicator of dementia risk. The value of SCD as a proxy marker, however, depends on the consistency of associations between subjective and objective cognitive measures across sociodemographic and psychological factors.

Methods: We evaluated baseline data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study (n=1615). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000383DOI Listing

Neural Basis of Long-term Musical Memory in Cognitively Impaired Older Persons.

Alzheimer Dis Assoc Disord 2020 May 6. Epub 2020 May 6.

Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada.

Objective: The objective of this study was to determine whether exposure to long-known music would evoke more extensive activation of brain regions minimally affected by Alzheimer disease (AD) pathology and outside traditional memory networks using a functional magnetic resonance imaging paradigm involving listening to long-known and recently-learned music in older adults with cognitive impairment to provide insight into mechanisms of long-term musical memory preservation in cognitively impaired older persons.

Methods: Seventeen subjects with a diagnosis of mild AD or mild cognitive impairment were recruited for this study. Subjects were scanned using functional magnetic resonance imaging while they performed a music listening task, which included short clips of personally selected music from the patient's past and newly-composed music heard for the first time 60 minutes before scanning. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000382DOI Listing

The Insular Cortex, Alzheimer Disease Pathology, and Their Effects on Blood Pressure Variability.

Alzheimer Dis Assoc Disord 2020 May 6. Epub 2020 May 6.

Department of Medicine, Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Recent findings indicate that the human cardiovascular system is regulated by a cortical network comprised of the insular cortex (Ic), anterior cingulate gyrus, and amygdala which is necessary for the regulation of the central autonomic network system. Alzheimer disease (AD) affects the Ic at a preclinical stage. The pathology of AD at the Ic is suggested to predispose the cardiovascular system to detrimental changes such as increased blood pressure variability (BPV). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000340DOI Listing

Vascular Dementia, Depression, and Financial Capacity Assessment.

Alzheimer Dis Assoc Disord 2020 May 1. Epub 2020 May 1.

School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

We still know little about financial capacity, which consists of multiple cognitive domains as well as specific skills, and the influence of depression in patients with vascular dementia (VaD). Participants were divided into 4 groups: (1) VaD with and (2) without depressive symptoms, (3) nondemented elders with and (4) without depression. The participants were examined with the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale (GDS-15), and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000374DOI Listing

Alpha-synuclein Levels in the Differential Diagnosis of Lewy Bodies Dementia and Other Neurodegenerative Disorders: A Meta-analysis.

Alzheimer Dis Assoc Disord 2020 Apr 24. Epub 2020 Apr 24.

Third Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Subjectives: Lewy body dementia (LBD) is the second most common type of neurodegenerative dementia after Alzheimer disease (AD). It is characterized by the accumulation of Lewy bodies and Lewy neurites which are composed of aggregated phosphorylated alpha-synuclein, which is a presynaptic neuronal protein genetically and neuropathologically linked to Parkinson disease and to LBD. Alpha-synuclein is thought to contribute to LBD pathogenesis and to linked to disruption of cellular homeostasis and neuronal death, through effects on various intracellular targets, including synaptic function. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000381DOI Listing

Social Inequalities in Life Expectancy and Mortality in People With Dementia in the United Kingdom.

Alzheimer Dis Assoc Disord 2020 Apr 23. Epub 2020 Apr 23.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus.

Introduction: Inequalities in life expectancy and mortality by social deprivation in the general population of the United Kingdom are widening. For people with dementia, data on potential gradients in life expectancy and mortality by social deprivation are sparse. This study aimed to explore potential differentials in life expectancy and mortality in people with dementia according to social deprivation. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000378DOI Listing

The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):105-111

National Alzheimer's Coordinating Center, University of Washington, Seattle, WA.

The field of dementia research is rapidly evolving, especially with regards to our understanding of the diversity of neuropathologic changes that underlie cognitive decline. Definitions and criteria for known conditions are being periodically revised and refined, and new findings are being made about neuropathologic features associated with dementia status. The database maintained by the National Alzheimer's Coordinating Center (NACC) offer researchers a robust, rapid, and statistically well-powered method to evaluate the implications of newly identified neuropathologic conditions with regards to comorbidities, demographic associations, cognitive status, neuropsychologic tests, radiographic findings, and genetics. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242145PMC

"My Parent's Body Is Sacred": Perspectives From Adult Latino Children About Brain Donation for Alzheimer Disease Research.

Alzheimer Dis Assoc Disord 2020 Mar 24. Epub 2020 Mar 24.

Department of Kinesiology and Nutrition, University of Illinois at Chicago.

Introduction: Brain donation is a critical part of advancing research addressing Alzheimer disease and related dementias (ADRD). Studies on ADRD with an option for brain donation are reliant on family members to fulfill the research participant's plan for brain donation. Thus, family members play a pivotal role in increasing brain donation rates, particularly among under-represented groups. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000377DOI Listing

Factor Consistency of Neuropsychological Test Battery Versions in the NACC Uniform Data Set.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):175-177

National Alzheimer's Coordinating Center, University of Washington, Seattle, WA.

The proprietary neuropsychological tests (Form C1) of the National Alzheimer's Coordinating Center (NACC) Uniform Data Set were replaced with nonproprietary versions (Form C2) chosen to closely model their proprietary counterparts. Correlations between analogous test pairs as measured in previous work were good (0.68-0. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242135PMC

Identifying Adaptive and Maladaptive Behaviors Following a Diagnosis of Mild Cognitive Impairment.

Alzheimer Dis Assoc Disord 2020 Mar 24. Epub 2020 Mar 24.

Alzheimer's Disease Center, Sanders-Brown Center on Aging, Lexington, KY.

Introduction: Individual reactions to a diagnosis of mild cognitive impairment (MCI) can vary in a wide range of both adaptive and maladaptive responses. Understanding such reactions to diagnosis is important to maximize adaptive responses that can promote continued independence.

Methods: In this pilot study, the Aging and Memory Quality of Life survey was developed to facilitate an understanding of adaptive and maladaptive behaviors results from a diagnosis of MCI. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000379DOI Listing

Conversion of Mild Cognitive Impairment to Alzheimer Disease in Monolingual and Bilingual Patients.

Alzheimer Dis Assoc Disord 2020 Feb 13. Epub 2020 Feb 13.

Rotman Research Institute at Baycrest.

Purpose: Conversion rates from mild cognitive impairment (MCI) to Alzheimer disease (AD) were examined considering bilingualism as a measure of cognitive reserve.

Methods: Older adult bilingual (n=75) and monolingual (n=83) patients attending a memory clinic who were diagnosed with MCI were evaluated for conversion to AD. Age of MCI and AD diagnoses and time to convert were recorded and compared across language groups. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000373DOI Listing
February 2020

Alzheimer Disease and Cancer: A National Inpatient Sample Analysis.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):122-127

Department of Neurology, Loma Linda University Health, Loma Linda.

Introduction: Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer. This inverse relationship was further explored. In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000369DOI Listing
January 2020

Association Between Gait, Cognition, and Gray Matter Volumes in Mild Cognitive Impairment and Healthy Controls.

Alzheimer Dis Assoc Disord 2020 Jan 21. Epub 2020 Jan 21.

Department of Neuroscience, University of Sheffield, Sheffield, UK.

Aims: To assess the correlation between cognitive functioning and 3 gait parameters (gait speed, cadence, and stride length) in persons with mild cognitive impairment (MCI) and cognitively healthy controls and investigate linear correlations between gait and gray matter volumes.

Materials And Methods: Participants were recruited at IRCCS San Camillo Hospital, Venice, Italy (MCI=43; age-matched controls=43). Participants underwent comprehensive neuropsychological assessment. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000371DOI Listing
January 2020

Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.

Alzheimer Dis Assoc Disord 2020 Jan 17. Epub 2020 Jan 17.

Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles.

Objective: Recent studies have suggested that diminished Ccr5 functioning has an effect on synaptic plasticity and hippocampal memory in mouse models. CCR5-delta32, a 32-bp frameshift deletion in human CCR5 encoding a nonfunctional receptor, has been reported to have a protective effect against human immunodeficiency virus infection but its role as a modifier of neurodegenerative disease has been minimally explored. We investigated whether the CCR5-delta32 polymorphism could have an effect in the context of human neurodegenerative diseases. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000367DOI Listing
January 2020

Impact of the Prevalence of Cognitive Impairment on the Accuracy of the Montreal Cognitive Assessment: The Advantage of Using two MoCA Thresholds to Identify Error-prone Test Scores.

Alzheimer Dis Assoc Disord 2020 Jan 13. Epub 2020 Jan 13.

Department of Methods and Statistics, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.

Objectives: The focus of this study is the classification accuracy of the Montreal Cognitive Assessment (MoCA) for the detection of cognitive impairment (CI). Classification accuracy can be low when the prevalence of CI is either high or low in a clinical sample. A more robust result can be expected when avoiding the range of test scores within which most classification errors are expected, with adequate predictive values for more clinical settings. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000365DOI Listing
January 2020

Anticholinergic Use Among the Elderly With Alzheimer Disease in South Korea: A Population-based Study.

Alzheimer Dis Assoc Disord 2020 Jan 7. Epub 2020 Jan 7.

Department of Public Health Science, Graduate School of Public Health and Institute of Health and Environment, Seoul National University.

Objectives: To investigate the characteristics of anticholinergic use in the elderly with Alzheimer disease (AD) compared with those in the non-AD elderly.

Methods: Using the Korean National Health Insurance Service Elderly cohort database, 388,629 adults aged 70 years and older in 2012 were included. The use of strong anticholinergic agents (ACs) in 2012 was quantified by standardized prescribed doses. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000370DOI Listing
January 2020

The Past as Seen by Women and Men With Alzheimer Disease: Sex Differences in Autobiographical Memory.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):170-174

Centre Hospitalier de Tourcoing, Unité de Gériatrie, Tourcoing.

Background: Although there is a large body of research demonstrating the negative effects of Alzheimer disease (AD) on autobiographical memory (ie, memory of personal information), little is known about sex differences in autobiographical retrieval in AD.

Methods: We addressed this issue by inviting patients with AD and healthy control participants to retrieve autobiographical memories and analyzed them with regard to specificity, subjective experience (ie, time travel, emotion, and visual imagery), and retrieval time.

Results: Analyses demonstrated no significant differences between women and men with AD with regard to autobiographical specificity, time travel, visual imagery, or retrieval time. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000363DOI Listing
January 2020

Prevalence of Mild Cognitive Impairment in the Elderly Population in Greece: Results From the HELIAD Study.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):156-162

1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School.

Introduction: Timely recognition of mild cognitive impairment (MCI) is essential in optimizing prevention and treatment for Alzheimer disease. Because of the paucity of data on MCI epidemiology in Greece and the variability of worldwide published results, we investigated the prevalence and determinants of MCI in the elderly population in Greece.

Methods: As part of the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD), we randomly selected 1960 individuals 65 years and older to undergo full neurological and neuropsychological assessment by a multidisciplinary team. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000361DOI Listing
January 2020

Capgras Syndrome in the Young: Schizophrenia or Alzheimer Disease?

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):94-96

Department of Neurology, National Neuroscience Institute.

This is a case report of an atypical presentation of early onset Alzheimer disease (EOAD) in a young patient with Capgras syndrome and cognitive impairment. The concurrent onset of psychiatric and cognitive symptoms prompted a detailed evaluation for a neurodegenerative disease. A 50-year-old male lawyer presented with low mood, apathy, delusions, and auditory hallucinations over 18 months. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000360DOI Listing
January 2020

Direct Mail Recruitment to a Potential Participant Registry.

Alzheimer Dis Assoc Disord 2019 Dec 9. Epub 2019 Dec 9.

Institute for Clinical and Translational Science.

Recruitment registries are novel tools to accelerate Alzheimer disease research accrual. Optimal methods to populate such registries remain largely unstudied. We sent postcards with 3 unique taglines (Alzheimer's Prevention Research, brain health research, general research) to 100,000 local residents aged 50 years and older to assess the effectiveness of recruiting to an online recruitment registry by mail. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000368DOI Listing
December 2019

Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):118-121

Health Sciences Research.

Introduction: The association of prostate cancer and androgen deprivation therapy (ADT) use with the odds of developing mild cognitive impairment (MCI) was determined in men from the population-based Mayo Clinic Study of Aging (MCSA).

Methods: The study included 2513 men (mean age of 73.1 y) enrolled in the MCSA. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242115PMC

Feasibility and Accuracy of Different Methods for Collecting Data on Falls Among Older People With Dementia.

Alzheimer Dis Assoc Disord 2019 Nov 25. Epub 2019 Nov 25.

Department of Psychology and Ageing & Dementia Research Centre.

This study compared different methods for collecting data on falls among people with dementia to identify which is most feasible and accurate. Eighty-three dyads, comprised of a community-dwelling person with dementia and their informal carer, participated in the TAi ChI for people with demenTia (TACIT) trial. Falls were collected prospectively over 6 months using monthly calendars, weekly and monthly telephone interviews, and 3-monthly telephone interviews with the carer. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000364DOI Listing
November 2019

Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):112-117

Department of Neurology, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO.

Background/objective: The AD8 informant-based screening instrument has been validated with molecular biomarkers of Alzheimer disease (AD) but not with the gold standard of neuropathologic AD. The objective of this study was to validate the AD8 with neuropathologic AD and compare its predictive performance with that of the Mini-Mental State Examination and both participant-derived and informant-derived subjective memory complaint (SMC) regarding the participant.

Methods: This longitudinal cohort study at the Knight Alzheimer Disease Research Center at Washington University included 230 participants, ages 50 to 91 years, who later had a neuropathologic examination. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217744PMC

Translation and Validation of 10/66 Dementia Diagnostic Battery in Urdu in Karachi, Pakistan.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):163-169

Stroke Institute, UPMC, Pittsburgh, PA.

Purpose: The 10/66 dementia research group (DRG) diagnostic tool was devised to diagnose dementia in people with low education in low and middle-income countries. This study aimed to validate the 10/66 DRG tool in Urdu in Pakistan.

Methodology: People older than or equal to 60 years were included: (1) With normal cognition: no/low education, high education, and depression; (2) People with mild and moderate dementia. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000359DOI Listing
October 2019
1 Read

Clinical Presentation of Sporadic Creutzfeldt-Jakob Disease in Han-Chinese.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):188-190

Department of Neurology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University.

The clinical presentation in Chinese patients with sporadic Creutzfeldt-Jakob disease (sCJD) may be unique due to the big difference in the codon 129 polymorphism of the prion protein gene (PRNP). This study retrospectively reviewed 26 cases of sCJD diagnosed in a single center in recent years. All 26 sCJD patients received brain magnetic resonance imaging scan, cerebrospinal fluid 14-3-3 protein detection, electroencephalogram, and PRNP gene screening. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000350DOI Listing
October 2019

High Prevalence of Social Cognition Disorders and Mild Cognitive Impairment Long Term After Stroke.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):72-78

Department of Neurology, Memory Centre.

Purpose: Social cognition disorders after stroke are poorly described. Yet, rehabilitation difficulties are frequent after stroke. This study aimed to evaluate the frequency of social cognition disorders 3 years after a first-ever stroke and to assess the factors associated with this condition. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000355DOI Listing
October 2019
1 Read

Clustering and Additive Effects of Nongenetic Risk Factors in Non-Autosomal-Dominant Degenerative and Vascular Young Onset Dementia.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):128-134

Dementia Centre for Research Collaboration, School of Psychiatry.

Introduction: Both genetic and nongenetic factors contribute to the risk profile of young onset dementia (YOD), but risk factors often co-occur. This matched case-control study examined whether nongenetic risk factors cluster together, to inform targeted prevention efforts.

Methods: Ninety-six participants with non-autosomal-dominant degenerative and/or vascular YOD and 175 controls were recruited to 2 Australian epidemiological studies. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000358DOI Listing
October 2019
1 Read

Trends in the Use of Medications and Supplements to Treat or Prevent Dementia: A Population-based Study.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):148-155

Departments of Psychiatry.

Objective: To examine older adults' use over time of agents to treat or prevent dementia or enhance memory.

Design: Longitudinal community study with 10-year annual follow-up (2006-2017).

Setting: Population-based cohort. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156330PMC
April 2021
1 Read

Association Between Neuropsychiatric Symptom Trajectory and Conversion to Alzheimer Disease.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):141-147

Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute.

Introduction: Neuropsychiatric symptoms (NPS) are both common in mild cognitive impairment and Alzheimer disease (AD). Studies have shown that some NPS such as apathy and depression are a key indicator for progression to AD.

Methods: We compared Neuropsychiatric Inventory (NPI) total score and NPI subdomain score between mild cognitive impairment-converters (MCI-C) and mild cognitive impairment-nonconverters (MCI-NC) longitudinally for 6 years using the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000356DOI Listing
October 2019
2 Reads

Subjective Memory Complaints Are an Important Surrogate for Objective Cognitive Performance in African Americans.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):79-84

Sanders-Brown Center on Aging.

Purpose: Subjective memory complaints (SMCs) have been shown to be associated with lower neuropsychological test scores cross-sectionally. However, it remains unclear whether such findings hold true for African American (AA) older adults.

Methods: Baseline visit data from the National Alzheimer's Coordinating Center database collected from September 2005 to March 2018 were used. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170708PMC
January 2021
1 Read

Locus of Control and Cognition in Older Adults With Type 1 Diabetes: Evidence For Sex Differences From the Study of Longevity in Diabetes (SOLID).

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):25-30

Kaiser Permanente Northern California Division of Research, Oakland.

Objective: Life expectancy for individuals with type 1 diabetes mellitus (T1DM) has increased recently; however, it is unknown how diabetes care attitudes affect late-life brain health.

Research Design And Methods: The Study of Longevity in Diabetes (SOLID) consists of 734 older adults with T1DM, reporting diabetes locus of control (dLOC), age of diabetes diagnosis and other demographics, history of hypoglycemic episodes, and depressive symptoms. Global and domain-specific (language, executive function, episodic memory, simple attention) cognitive functioning was assessed at in-person interviews. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047565PMC
January 2021

Older Adults With Subjective Cognitive Decline Worry About the Emotional Impact of Cognitive Test Results.

Alzheimer Dis Assoc Disord 2020 Apr-Jun;34(2):135-140

School of Graduate Psychology, Pacific University, Hillsboro, OR.

Introduction: Older adults with subjective cognitive decline (SCD) would benefit from routine cognitive testing as they are twice as likely to develop dementia. Worries about concerning test results may diminish participation. The current study aimed to characterize the pattern of worries among older adults with and without SCD. Read More

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http://Insights.ovid.com/crossref?an=00002093-900000000-9933
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http://dx.doi.org/10.1097/WAD.0000000000000354DOI Listing
October 2019
4 Reads

Sleep Quality and Cognitive Function in Type 1 Diabetes: Findings From the Study of Longevity in Diabetes (SOLID).

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):18-24

Kaiser Permanente Northern California Division of Research, Oakland.

Study Objective: The objective was to examine the association between sleep quality and global and domain-specific cognitive function among older individuals with type 1 diabetes (T1D).

Methods: We evaluated 695 individuals with T1D aged 60 years or above who participated in the baseline assessment of the Study of Longevity in Diabetes (SOLID), which captured subjective sleep quality (Pittsburgh Sleep Quality Index) and global and domain-specific (language, executive function, episodic memory, and simple attention) cognitive function. Multivariable linear regressions estimated the associations between sleep quality quartiles and overall and domain-specific cognitive function adjusting for age, sex, race/ethnicity, education, depressive symptoms, and severe hypoglycemic episodes. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047548PMC
January 2021
2 Reads

Retention of Alzheimer Disease Research Participants.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):299-306

Institute for Memory Impairments and Neurological Disorders.

Introduction: Participant retention is important to maintaining statistical power, minimizing bias, and preventing scientific error in Alzheimer disease and related dementias research.

Methods: We surveyed representative investigators from NIH-funded Alzheimer's Disease Research Centers (ADRC), querying their use of retention tactics across 12 strategies. We compared survey results to data from the National Alzheimer's Coordinating Center for each center. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878201PMC
October 2020
2 Reads

Symbol Comprehension in Patients With Alzheimer Disease Dementia, Mild Cognitive Impairment, and Major Depressive Disorder.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):85-93

Department of Psychiatry and Psychotherapy, Research Division.

Introduction: Previous research suggests that specific symbol features attenuate symbol comprehension deficits in seniors suffering from Alzheimer disease dementia (ADD). However, it remains unclear whether these findings also apply to other disorders associated with cognitive dysfunctions.

Methods: Ninety healthy controls, 30 patients with major depressive disorder (MDD), 35 patients with mild cognitive impairment (MCI), and 55 patients with ADD performed a Symbol Processing Task with 4 different symbol categories. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000347DOI Listing
October 2019
2 Reads

Blood Pressure and Memory: Novel Approaches to Modeling Nonlinear Effects in Longitudinal Studies.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):291-298

Departments of Biostatistics.

Background: Linear models cannot capture nonlinear associations when the relationships between cognition and risk factors vary across risk levels. We demonstrate a method of modelling nonlinear associations using the example of blood pressure (BP) and memory.

Methods: We measured memory and BP (in mm Hg) annually for 10 years in a population-based cohort (N=1982) aged 65+. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878165PMC
October 2020

Virtual Support Groups for Informal Caregivers of Individuals With Dementia: A Scoping Review.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):362-369

Department of Neurology, University of Florida College of Medicine.

Objective: The purpose of this scoping systematic review was to inform virtual support group development for informal caregivers of dementia by identifying published approaches, outcomes, barriers, and facilitators.

Methods: A scoping systematic review was performed using 5 search engines. Studies were included if they utilized virtual support groups for informal caregivers of persons with dementia. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000349DOI Listing
October 2019

Behaviors Characteristic of Autism Spectrum Disorder in a Geriatric Cohort With Mild Cognitive Impairment or Early Dementia.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):66-71

The Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.

Introduction: Autism spectrum disorder (ASD) represents a heterogenous cluster of clinical phenotypes that are classically diagnosed by the time of adolescence. The possibility of late-life emergence of ASD has been poorly explored.

Methods: To more fully characterize the possibility of late-life emergence of behaviors characteristic of ASD in mild cognitive impairment and AD, we surveyed caregivers of 142 older persons with cognitive impairment from the University of Kentucky Alzheimer's Disease Center Longitudinal Cohort using the Gilliam Autism Rating Scale-2. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047536PMC
January 2021
1 Read

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):327-330

Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine.

Objective: A rare variant in TREM2 (p.R47H, rs75932628) has been consistently reported to increase the risk for Alzheimer disease (AD), while mixed evidence has been reported for association of the variant with other neurodegenerative diseases. Here, we investigated the frequency of the R47H variant in a diverse and well-characterized multicenter neurodegenerative disease cohort. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050643PMC
October 2020
6 Reads

Mortality and Associated Risk Factors in Community-Dwelling Persons With Early Dementia.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):40-46

VISN 8 Patient Safety Center of Inquiry, James A. Haley Veterans Hospital and Clinics, Tampa, FL.

Objective: Examine mortality and associations with baseline characteristics among Veterans with early dementia.

Methods: Participants included dyads of community-based Veterans with early dementia and their caregivers (N=143) enrolled in a previous longitudinal study. Department of Veterans Health Affairs' electronic records were used to retrospectively collect Veteran mortality outcomes, over a 6-year period. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000343DOI Listing
September 2019
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Diagnosis of Rapidly Progressive Dementia in a Referral Center in Argentina.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):54-58

Departments of Neurology.

Introduction: Rapidly progressive dementia (RPD) is a broadly defined clinical syndrome. Our aim was to describe clinical and ancillary study findings in patients with RPD and evaluate their diagnostic performance for the identification of nonchronic neurodegenerative rapidly progressive dementia (ncnRPD).

Methods: We reviewed clinical records and ancillary methods of patients evaluated for RPD at our institution in Buenos Aires, Argentina from 2011 to 2017. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000337DOI Listing

Frontotemporal Dementia Knowledge Scale: Development and Preliminary Psychometric Properties.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):59-65

Department of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO.

Objective: Frontotemporal dementia (FTD) accounts for ∼10% of dementia cases and is the most common cause of early-onset dementia. However, no well-validated instrument currently exists to measure knowledge about FTD. In this study, we used systematic scale development procedures to create a scale to measure knowledge of FTD based on a contemporary understanding of the disease. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000344DOI Listing

The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):47-53

Departments of Geriatric Medicine.

Objective: Neuroinflammation may play an important role in the pathogenesis and progression of Alzheimer disease (AD). The aim of the present study was to detect whether increased inflammatory activity at baseline could predict cognitive and functional decline in patients with amnestic mild cognitive impairment (aMCI) or AD dementia after 2 years.

Methods: Serum samples from 242 memory clinic patients with an aMCI (n=88) or AD dementia (n=154) were analyzed for C-reactive protein and for 14 other inflammatory markers [interleukin (IL)-1β, interleukin-1 receptor antagonist, IL-6, IL-10, IL-12p40, IL-17a, IL-18, IL-22, IL-33, tumor necrosis factor, cluster of differentiation 40 ligand, interferon-γ, chemokine ligand (CCL) 2, and CCL4] by bead-based multiplex immunoassay. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000342DOI Listing
August 2019
2 Reads

Willingness to Undergo a Risky Treatment to Improve Cognition Among Persons With Cognitive Impairment Who Received an Amyloid PET Scan.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):1-9

Department of Health Services, Policy & Practice, Brown University School of Public Health.

Objective: To evaluate determinants of willingness to accept a treatment to return memory to normal among persons with cognitive impairment who received an amyloid positron emission tomography (PET) scan and their care partner and discordance in risk taking.

Methods: Using data from CARE-IDEAS (n=1872 dyads), a supplement of the Imaging Dementia-Evidence for Amyloid Scanning study, we predicted scan recipient's willingness to accept a risky treatment, the risk care partners believed their care recipient would accept, and discordance in these perceptions.

Results: Scan recipients were willing to accept a treatment with a 27. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015762PMC
January 2021
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Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults.

Alzheimer Dis Assoc Disord 2020 Jan-Mar;34(1):31-39

Departments of Ophthalmology and Visual Sciences.

Background: Relationships between brain-derived neurotrophic factor (BDNF), insulin-like growth factor (IGF-1), aldosterone, and cognition in aging were evaluated in the population-based Epidemiology of Hearing Loss Study (1993 to present).

Methods: Beginning in 1998 to 2000, cognitive impairment was assessed by report of physician diagnoses and the Mini-Mental State Examination. In 2009 to 2010 and 2013 to 2016, information was collected on diagnosis of mild cognitive impairment/dementia. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995426PMC
January 2021
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Duration of Antipsychotic Medication Use by Aged Care Facility Residents With Dementia.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):331-338

Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia.

Introduction: Guidelines recommend short-term targeted use of antipsychotic medications for behavioral and psychological symptoms of dementia only when other strategies have failed. Antipsychotic prescribing in dementia is common internationally, but data on duration of use are limited. Our objectives were to determine duration, time to initiation, and prevalence of antipsychotic use among people with dementia. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000336DOI Listing

A Comparison of Electronic and Paper Versions of the Montreal Cognitive Assessment.

Alzheimer Dis Assoc Disord 2019 Jul-Sep;33(3):272-278

Departments of Speech-Language Pathology.

Objective: The objective of this study was to investigate older adults' performance on the paper and electronic Montreal Cognitive Assessment (eMoCA).

Design: Repeated measures and correlational design.

Participants: A convenience sample of 40 adults over 65 years of age living in the community. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000333DOI Listing

Differential Methylation Levels in CpGs of the BIN1 Gene in Individuals With Alzheimer Disease.

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):321-326

Neurosciences Research Group, Faculty of Medicine.

Introduction: Late-onset Alzheimer disease (LOAD) is the most common dementia worldwide. APOE-[Latin Small Letter Open E]4 and BIN1 (Bridging Integrator 1) have been implicated in the pathogenesis of this disease, but, although DNA methylation of dinucleotide CpGs in the BIN1 gene influences alterations, it has not been studied in Hispanics.

Objective: The objective of this study was to evaluate the BIN1 3' intergenic region DNA methylation patterns in a Colombian sample of LOAD patients. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000329DOI Listing

Perspectives of African American Older Adults on Brain Health: "Brains Get Tired Too".

Alzheimer Dis Assoc Disord 2019 Oct-Dec;33(4):354-358

Department of Neurology and Sanders-Brown Center on Aging, University of Kentucky.

Background: Statistics suggest that African Americans have a disproportionately high prevalence of Alzheimer disease (AD), yet are less likely to enroll in AD clinical trials than white individuals. Although research has previously identified various barriers to participation, relatively little is known about how to overcome these barriers and engage African American individuals in AD research. The purpose of this study is to better understand how African Americans conceptualize brain health and their ability to influence healthy brain aging. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181952PMC
October 2020
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