1,804 results match your criteria Alzheimer disease and associated disorders[Journal]


Awareness in Dementia: Development and Evaluation of a Short Version of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s) in Brazil.

Alzheimer Dis Assoc Disord 2019 Apr 4. Epub 2019 Apr 4.

Department of Psychology, Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.

Awareness of disease is defined as the recognition of changes caused by the deficits related to the disease process. We aimed to examine the psychometric properties of the short versions of the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia (ASPIDD-s), a multidimensional awareness scale. Using a cross-sectional design, we included 201 people with dementia and their family caregivers. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000306DOI Listing
April 2019
2 Reads

Women and Men Presenting to a Rural and Remote Memory Clinic in Saskatchewan, Canada Show Similar Cognitive Findings for Dementia.

Alzheimer Dis Assoc Disord 2019 Apr 4. Epub 2019 Apr 4.

Rural and Remote Memory Clinic & University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Introduction: The course of dementia may differ between men and women. Men, for example, are more likely to exhibit aggression. It is unclear if sex differences are present at initial presentation. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000307DOI Listing
April 2019
1 Read

Cognitive Complaints in Nondemented Parkinson's Disease Patients and Their Close Contacts do not Predict Worse Cognitive Outcome.

Alzheimer Dis Assoc Disord 2019 Apr 4. Epub 2019 Apr 4.

Division of Neurology, Morton and Gloria Shulman Movement Disorders Center and the Edmond J Safra Program in Parkinson's disease, Toronto Western Hospital, University of Toronto.

Objectives: The main purpose of this study was to investigate 4 methods of eliciting subjective cognitive complaints (SCCs) in Parkinson's disease (PD) patients without dementia and determine the relationship between their SCC and cognitive performance.

Design: This study was a retrospective analysis of a prospective cohort study.

Setting: Six North American movement disorder clinics. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000301DOI Listing
April 2019
2 Reads

Which MCI Patients Should be Included in Prodromal Alzheimer Disease Clinical Trials?

Alzheimer Dis Assoc Disord 2019 Apr 4. Epub 2019 Apr 4.

Institute for Memory Impairments and Neurological Disorders.

Background: Prodromal Alzheimer disease (AD) clinical trials enroll patients with mild cognitive impairment (MCI) meeting biomarker criteria, but specific enrollment criteria vary among trials.

Methods: We used data from AD Neuroimaging Initiative (ADNI) MCI participants to assess AD biomarker eligibility, variation in trial outcome measures, and statistical power.

Results: Most (65%) participants meet eligibility criteria based on low cerebrospinal fluid amyloid beta (Aβ). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000303DOI Listing
April 2019
2 Reads

Identification of Sexual Disinhibition in Dementia by Family Caregivers.

Alzheimer Dis Assoc Disord 2019 Mar 12. Epub 2019 Mar 12.

Department of Psychological Sciences, Kent State University, Kent, OH.

Purpose: Sexual disinhibition in dementia is understudied and discrepant frequency rates are reported. Measures designed to capture general disinhibition may under-identify sexual disinhibition, and lack of assessment uniformity may contribute to inconsistent endorsement. The current study aimed to determine: (1) whether an item from a commonly used measure tapping into general disinhibition would detect sexual disinhibition, (2) whether differently worded items specifically addressing sexual disinhibition would elicit inconsistent endorsement, and (3) whether different caregiver types would yield discrepant endorsement. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000302DOI Listing

Differences in Awareness of Disease Between Young-onset and Late-onset Dementia.

Alzheimer Dis Assoc Disord 2019 Mar 12. Epub 2019 Mar 12.

Center for Alzheimer's disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro.

Introduction: Awareness of disease is the ability to acknowledge changes caused by deficits related to the disease process. We aimed to investigate whether there are differences in awareness of disease between young-onset dementia (YOD) and late-onset dementia (LOD) and examined how awareness interacts with cognitive and clinical variables.

Materials And Methods: Using a cross-sectional design, 49 people with YOD and 83 with LOD and their caregivers were included. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000299DOI Listing
March 2019
7 Reads

A Comprehensive Model of Factors Associated With Subjective Perceptions of "Living Well" With Dementia: Findings From the IDEAL Study.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):36-41

Wales Institute for Social and Economic Research, Data and Methods, Cardiff University, Cardiff.

Introduction: We aimed to better understand what predicts the capability to "live well" with dementia by identifying the relative contribution of life domains associated with the subjective experience of living well.

Methods: We analyzed data from 1547 individuals with mild-to-moderate dementia in the IDEAL cohort. We generated a "living well" latent factor from measures of quality of life, satisfaction with life, and well-being. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416010PMC
February 2019
7 Reads

A Comprehensive Model of Factors Associated With Capability to "Live Well" for Family Caregivers of People Living With Mild-to-Moderate Dementia: Findings From the IDEAL Study.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):29-35

Wales Institute for Social and Economic Research, Data, and Methods, Cardiff University, Cardiff.

Introduction: Understanding key influences on outcomes for caregivers of people with dementia is hampered by inconsistent conceptualization and measurement of outcomes and limited evidence about the relative impact of different variables. We aimed to address these issues.

Methods: We analyzed data from 1283 caregivers of community-dwelling individuals with mild-to-moderate dementia in the Improving the experience of Dementia and Enhancing Active Life cohort study. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416095PMC
February 2019
4 Reads

Primary Endpoints in Current Phase II/III Trials for Alzheimer Disease: A Systematic Survey of Trials Registered at ClinicalTrials.gov.

Alzheimer Dis Assoc Disord 2019 Feb 5. Epub 2019 Feb 5.

Department of Health Promotion of Human Behavior, Kyoto University Graduate School of Medicine/School of Public Health, Yoshida Konoe-cho, Sakyo-ku, Kyoto.

This study examined the primary and secondary endpoints used by recent phase II/III randomized controlled trials (RCTs) of drugs for the Alzheimer disease. We searched the Clinical Trials.gov database to identify all RCTs registered from January 1, 2011 until August 19, 2018. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000297DOI Listing
February 2019
1 Read

Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):7-14

Institute of Neurology, Medical University of Vienna.

Purpose: Understanding the healthy brain aging process is key to uncover the mechanisms that lead to pathologic age-related neurodegeneration, including progression to Alzheimer disease (AD). We aimed to address the issue of pathologic heterogeneity that often underlies a clinical AD diagnosis.

Methods: We performed a deep whole-genome sequencing study aiming to identify variants that are associated specifically with healthy brain aging. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000294DOI Listing
January 2019

Prevalence of Mild Cognitive Impairment Among Older People in Kazakhstan and Potential Risk Factors: A Cross-sectional Study.

Alzheimer Dis Assoc Disord 2019 Jan 23. Epub 2019 Jan 23.

Department of Epidemiology and Geriatric Medicine, School of Public Health and Centre for Education and Research on Ageing University of Sydney, Sydney, Australia.

Background: There have been no epidemiological studies of mild cognitive impairment (MCI) in Central Asia.

Objective: The objective of this study was to describe the prevalence of, and risk factors for, MCI in an urban population in Kazakhstan.

Methods: Adults aged 60 years and over were randomly selected from registers of 15 polyclinics in Almaty. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000298DOI Listing
January 2019

An Algorithm to Characterize a Dementia Population by Disease Subtype.

Alzheimer Dis Assoc Disord 2019 Jan 23. Epub 2019 Jan 23.

Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, MD.

Purpose: Identification of Alzheimer disease and related dementias (ADRD) subtypes is important for pharmacologic treatment and care planning, yet inaccuracies in dementia diagnoses make ADRD subtypes hard to identify and characterize. The objectives of this study were to (1) develop a method to categorize ADRD cases by subtype and (2) characterize and compare the ADRD subtype populations by demographic and other characteristics.

Methods: We identified cases of ADRD occurring during 2008 to 2014 from the OptumLabs Database using diagnosis codes and antidementia medication fills. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000295DOI Listing
January 2019
1 Read

Alzheimer's Environmental and Genetic Risk Scores are Differentially Associated With General Cognitive Ability and Dementia Severity.

Alzheimer Dis Assoc Disord 2019 Jan 23. Epub 2019 Jan 23.

Centre for Research on Ageing, Health and Wellbeing, Australian National University, Canberra, Australian Capital Territory.

Purpose: We investigated the association of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) and an Alzheimer disease (AD) genetic risk score (GRS) with cognitive performance.

Methods: The ANU-ADRI (composed of 12 risk factors for AD) and GRS (composed of 25 AD risk loci) were computed in 1061 community-dwelling older adults. Participants were assessed on 11 cognitive tests and activities of daily living. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000292DOI Listing
January 2019
10 Reads

Dementia Reported Missing: Use of an Online Search Engine to Track Outcomes in Persons With Dementia Reported Missing.

Alzheimer Dis Assoc Disord 2019 Jan 23. Epub 2019 Jan 23.

Neurology Department, Case Western Reserve University School of Medicine.

Background: Persons with dementia (PWD) reported missing are known to be at high risk for mortality. Analysis of online search engines' reports of missing PWD may show patterns in the data of this relatively common event and the broad patterns relevant to mortality risk factors.

Methods: We searched Google news for PWD reported missing for 2015. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000296DOI Listing
January 2019

Copper in Glucose Intolerance, Cognitive Decline, and Alzheimer Disease.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):77-85

Department of Medicine, Diabetes Research Institute.

Trace metal dyshomeostasis has been linked to loss of cognitive performance. In particular, a disturbance in the regulation of copper (Cu), characterized by an increase in circulating Cu not bound to ceruloplasmin (non-Cp Cu), is thought to play a role in the development of Alzheimer disease (AD) and other neurodegenerative diseases in the aging population. Non-Cp Cu is redox active and its toxicity is thought to result from its ability to accelerate oxidative stress and advanced glycation endproduct (AGE) formation, leading to extracellular matrix damage in tissues including the brain. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000280DOI Listing
January 2019

Primary Progressive Aphasia: Natural History in an Italian Cohort.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):42-46

Departments of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA).

Background/aims: Few longitudinal studies have explored the progression of cognitive and functional impairment of patients with primary progressive aphasia (PPA). The aims of the study were to describe the clinical, neuroimaging, and genetic features of a cohort of 68 PPA patients, and to outline the natural history of the disease.

Materials And Methods: A sample of 23 patients with the logopenic variant, 26 with the nonfluent/agrammatic variant, and 19 with the semantic variant was retrospectively collected and followed-up for a maximum of 6 years. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000282DOI Listing
January 2019
1 Read

Distinguishing Dementia With Lewy Bodies From Alzheimer's Disease: What is the Influence of the GBA Genotype in Ashkenazi Jews?

Alzheimer Dis Assoc Disord 2019 Jan 10. Epub 2019 Jan 10.

Center for Memory and Attention Disorders.

Cognitive deficits beyond memory impairment, such as those affecting language production or executive functioning, can be useful in clinically distinguishing between dementia syndromes. We tested the hypothesis that Ashkenazi Jewish (AJ) patients who have dementia with Lewy bodies (DLB) and carry glucocerebrosidase (GBA) mutations will have verbal fluency deficits different from those found in Alzheimer's disease (AD), whereas AJ patients with DLB who have no GBA mutations will have similar deficits in verbal fluency to those found in AD. We compared performance in phonemic and semantic verbal fluency tasks in 44 AJ patients with DLB and 20 patients with AD, matched for age, education, and age of immigration. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000283DOI Listing
January 2019
1 Read

Bilingualism in Primary Progressive Aphasia: A Retrospective Study on Clinical and Language Characteristics.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):47-53

Neurocognition Unit, Department of Neurology, Hospital de Braga, Sete Fontes-São Victor, Braga, Portugal.

Background: Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive deterioration of language. Being rare, reports of PPA in multilingual individuals are scarce, despite more than half of the world population being multilingual.

Methods: We describe clinical characteristics of 33 bilingual patients with PPA, including symptom presentation and language deficits pattern in their first (L1) and second language (L2), through a systematic literature review and new cases retrospectively identified in 5 countries. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469495PMC
January 2020
7 Reads

Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia: A Retrospective Analysis.

Alzheimer Dis Assoc Disord 2019 Jan 10. Epub 2019 Jan 10.

Center of Cognitive and Behavioral Disorders.

The use of biomarkers has recently supported the association between Alzheimer's disease (AD) pathology and the logopenic variant of primary progressive aphasia (PPA). We aim to investigate possible differences in cerebrospinal fluid (CSF) biomarker concentrations in the three PPA variants, and to assess any agreement between CSF biomarkers and (18)F-florbetapir PET. A group of 10 PPA were retrospectively enrolled. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000289DOI Listing
January 2019
7 Reads

Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia.

Alzheimer Dis Assoc Disord 2019 Jan 10. Epub 2019 Jan 10.

Knight Alzheimer Disease Research Center.

Introduction: We investigated whether cholinesterase inhibitors (ChEIs) benefit cognitive outcomes in mild cognitive impairment due to Alzheimer disease (MCI-AD) and in mild AD dementia (ADdem).

Methods: Data from 2242 individuals, clinically diagnosed with MCI-AD [Clinical Dementia Rating (CDR), 0 or 0.5] or with mild ADdem (CDR, 0. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000291DOI Listing
January 2019
14 Reads

Long-term Changes in 18F-Flutemetamol Uptake in Nondemented Older Adults.

Alzheimer Dis Assoc Disord 2019 Jan 8. Epub 2019 Jan 8.

Center for Quantitative Cancer Imaging, Huntsman Cancer Institute.

Purpose: Longitudinal studies into the variability of F-Flutemetamol uptake are lacking.

Methods/patients: Therefore, the current study examined change in F-Flutemetamol uptake in 19 nondemented older adults (65 to 82 y old) who were either cognitively intact or had Mild Cognitive Impairment (MCI) who were scanned twice across 3.6 years. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000293DOI Listing
January 2019
2 Reads

Thermal Injury Deaths of Community-dwelling Older People With Dementia.

Alzheimer Dis Assoc Disord 2019 Jan 8. Epub 2019 Jan 8.

Department of Forensic Medicine.

Although people with dementia are prone to the risk of fire and burn injuries, the relationship between fatal thermal injuries and dementia has not been investigated. We examined coronial files in the state of Victoria, Australia between July 1, 2000 and December 31, 2014, for unintentional thermal injury causing deaths of community dwelling people, aged 65 years and older to identify those with dementia. Mortality for Victorian populations with and without dementia was calculated using direct age standardization. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000290DOI Listing
January 2019

Reduced Awareness of Memory Deficit is Associated With Increased Medicare Home Health Care Use in Dementia.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):62-67

Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the G.H. Sergievsky Center, Columbia University Medical Center.

Objective: The objective of this study was to examine whether reduced awareness of memory deficits in individuals with dementia is associated with more frequent need for Medicare home health care services.

Methods: Cross-sectional analyses were conducted in a multicenter, clinic-based cohort. In total, 192 participants diagnosed with dementia and their informants were independently asked whether or not the participant demonstrated cognitive symptoms of dementia related to memory and word-finding. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000287DOI Listing
December 2018
1 Read

Examining the Complicated Relationship Between Depressive Symptoms and Cognitive Impairment in Preclinical Alzheimer Disease.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):15-20

Department of Neurology, Washington University School of Medicine.

Introduction: The relationships between Alzheimer disease (AD), cognitive performance, and depression are poorly understood. It is unclear whether depressive features are a prodrome of AD. In addition, some studies of aging exclude depressed individuals, which may inappropriately limit generalizability. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389418PMC
January 2020
2 Reads

Self-reported Lifestyle Activities in Relation to Longitudinal Cognitive Trajectories.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):21-28

Department of Neurology, Johns Hopkins University School of Medicine.

Background: Few studies have examined the relationship between lifestyle activity engagement and cognitive trajectories among individuals who were cognitively normal at baseline.

Objective: To examine the relationship of current engagement in lifestyle activities to previous cognitive performance among individuals who were cognitively normal at baseline, and whether this relationship differed for individuals who subsequently developed mild cognitive impairment (MCI), or by APOE-4 genotype, age, and level of cognitive reserve.

Methods: Participants (N=189) were primarily middle-aged (M=56. Read More

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http://Insights.ovid.com/crossref?an=00002093-900000000-9940
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http://dx.doi.org/10.1097/WAD.0000000000000281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389389PMC
January 2020
12 Reads

Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):351-358

Department of Neurology, Washington University School of Medicine, St. Louis, MO.

Introduction: In 2015, the US Alzheimer's Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers.

Methods: UDS Version 3 was developed after years of coordination between the National Institute on Aging-appointed Clinical Task Force (CTF), clinicians from ∼30 ADCs, and the National Alzheimer's Coordinating Center (NACC). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249084PMC
October 2018
18 Reads

The Impact of Paratonia on Fine and Gross Motor Function in Older Adults With Mild and Moderate Dementia.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):54-61

Department of Rehabilitation Sciences and Physiotherapy, Ghent University.

Background: Dementia is associated with impairment in gait, balance, and fine motor function. Paratonia, a form of hypertonia, is often present in severe dementia. However, little is known about muscle tone in early dementia, and the eventual relation between muscle tone abnormalities and changes in fine and gross motor function. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000278DOI Listing
October 2018
5 Reads

Increased Health Care Utilization in Dementia Subtypes Before Diagnosis.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):326-332

University of Maryland School of Pharmacy, Baltimore, MD.

Introduction: Prior studies have reported higher health care utilization (HCU) leading up to diagnosis of the Alzheimer disease and related dementia (ADRD), but none have assessed variation in HCU by ADRD subtype or examined disease-specific HCU. The objectives of this study were to identify ADRD subtypes and: (1) characterize all-cause and (2) disease-specific HCU during the 3 years preceding diagnosis, and (3) determine if HCU varied by ADRD subtype.

Methods: We used data from the OptumLabs Data Warehouse 2008 to 2014 to identify ADRD subtypes (total N=36,838) using an algorithm based on temporal sequencing of diagnoses and provider type. Read More

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http://Insights.ovid.com/crossref?an=00002093-900000000-9940
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http://dx.doi.org/10.1097/WAD.0000000000000277DOI Listing
October 2018
11 Reads

The p.R47H Variant of TREM2 Gene is Associated With Late-onset Alzheimer Disease in Colombian Population.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):305-308

Neurosciences Research Group, Genetics Institute.

Objective: We evaluated the association of several single-nucleotide polymorphisms in the triggering receptor expressed on myeloid cells 2 (TREM2) gene in a Colombian sample of late-onset Alzheimer disease (LOAD).

Methods: The p.Q33* (rs104894002), p. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000275DOI Listing
September 2018
1 Read

Rapidly Progressive Dementia in the Outpatient Clinic: More Than Prions.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):291-297

The Charles F and Joanne Knight Alzheimer Disease Research Center.

Background: Published approaches to the evaluation and management of patients with rapidly progressive dementia (RPD) have been largely informed by experience at academic hospitals and national centers specializing in the diagnosis of Creutzfeldt-Jakob disease. Whether these approaches can be applied to patients assessed within lower-acuity outpatient settings is unknown.

Methods: A total of 96 patients with suspected RPD were assessed within the Washington University School of Medicine (Saint Louis, MO) outpatient memory clinic from February 2006 to February 2016. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249048PMC
October 2019
2 Reads

Subjective Cognitive Impairment and the Broad Autism Phenotype.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):284-290

Departments of Neurology.

Introduction: Roughly 4% to 23% of the population embody stress prone personality and other traits characterizing a subclinical "broad autism phenotype" (BAP). Subjective cognitive impairment (SCI) among healthy elderly is associated with psychological distress leading us to predict BAP would be associated with SCI.

Methods: The Autism Spectrum Quotient, a self-administered 50 item questionnaire, was completed by 419 consecutive members of the Arizona APOE Cohort who underwent neuropsychological testing every 2 years. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249104PMC
October 2019
5 Reads

Nutritional Status is Associated With Severe Dementia and Mortality: The Cache County Dementia Progression Study.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):298-304

Utah State University, Logan, UT.

Purpose: Studies have reported faster cognitive/functional decline in persons with dementia (PWD) with malnutrition. We investigated whether baseline nutritional status predicted severe dementia and mortality in a population-based sample.

Patients: A maximum of 300 PWD were assessed annually for up to 8. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345543PMC
October 2019
12 Reads

Case Report of a 63-Year-Old Patient With Alzheimer Disease and a Novel Presenilin 2 Mutation.

Alzheimer Dis Assoc Disord 2018 Aug 24. Epub 2018 Aug 24.

St. Joseph's Health Care London-Parkwood Institute.

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http://dx.doi.org/10.1097/WAD.0000000000000269DOI Listing
August 2018
1 Read

Behavioral Variant Frontotemporal Dementia-like Syndrome With Novel Heterozygous TREM2 Frameshift Mutation.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):75-76

Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK.

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http://dx.doi.org/10.1097/WAD.0000000000000271DOI Listing
August 2018
1 Read

The Effect of Changing the Amyloid β42 Cut-off of Cerebrospinal Fluid Biomarkers on Alzheimer Disease Diagnosis in a Memory Clinic Population in Norway.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):72-74

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

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http://dx.doi.org/10.1097/WAD.0000000000000268DOI Listing

Birth in High Infant Mortality States and Dementia Risk in a Cohort of Elderly African American and White Health Care Members.

Alzheimer Dis Assoc Disord 2019 Jan-Mar;33(1):1-6

Kaiser Permanente Division of Research, Oakland.

Importance: Birth in areas with high infant mortality rates (IMRs) has been linked to worse long-term health outcomes, yet it is completely unknown if it impacts dementia risk.

Methods: In total 6268 health care members were followed for dementia diagnosis from 1996 to 2015. Birth state IMRs from 1928 were ranked into quartile (worst IMRs quartile range, whites: 69 to 129 deaths/1000 live births, Non-whites: 129 to 277 deaths/1000 live births). Read More

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http://dx.doi.org/10.1097/WAD.0000000000000270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374212PMC
January 2020
2 Reads

Police Interactions Among Neuropathologically Confirmed Dementia Patients: Prevalence and Cause.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):346-350

Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund/Department of Clinical Pathology, Region Skane.

Objective: The aim of this study was to investigate and compare the prevalence and recurrence of police interaction (PI) with patients diagnosed with dementia. We also aimed to study the reason behind the PI, the time of occurrence of PI, and potential consequences of the PI.

Methods: For this retrospective medical records' review, we included 281 cases with a neuropathologic dementia diagnosis from the Department of Pathology, Region Skane/Lund University, between 1967 and 2013. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000267DOI Listing
August 2018
19 Reads

Pathologies Underlying Longitudinal Cognitive Decline in the Oldest Old.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):265-269

Oregon Health & Science University.

Background: Understanding contributions of different brain pathologies to domain-specific cognitive trajectories in the oldest old is crucial to guide future intervention studies.

Methods: Two-hundred-twenty Oregon Alzheimer's Disease Center research participants who were cognitively intact at entry were followed on average for 7.3 years with annual neuropsychological testing until death (mean age, 93. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249087PMC
October 2019
24 Reads

Improved Gray Matter Atrophy Detection in Alzheimer Disease in Chinese Populations Using Chinese Brain Template.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):309-313

Department of Radiology, Xuanwu Hospital, Capital Medical University.

Objective: This study aimed to test the hypothesis that the statistical Chinese brain template would be more effective to detect gray matter (GM) changes in patients with Alzheimer disease (AD) in Chinese populations.

Materials And Methods: In total, 50 patients with AD and 50 sex-matched and age-matched healthy controls were included in this study. Chinese2020, a typical statistical Chinese brain template, and MNI152, a typical Caucasian template were used for spatial normalization respectively. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000264DOI Listing
July 2018
9 Reads

Alzheimer Disease Clinical Trial Recruitment: Does Participation in a Brief Cognitive Screen at a Community Health Fair Promote Research Engagement?

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):333-338

Sanders Brown Center on Aging.

Background: Slow participant recruitment impedes Alzheimer disease research progress. Although research suggests that direct involvement with potential participants supports enrollment, strategies for how best to engage potential participants are still unclear.

Purpose: This study explores whether community health fair (HF) attendees who engage in a brief cognitive screen (BCS) are more likely to enroll in research than attendees who do not complete a BCS. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249071PMC
October 2019
1 Read

Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):276-283

Medicine, Medical Ethics and Health Policy, and Neurology, Penn Memory Center, University of Pennsylvania.

Purpose: To examine in persons with varying degrees of cognitive impairment the relationship between self-reports of cognitive complaints and quality of life (QOL).

Methods: Older adults (n=259) with normal cognition, mild cognitive impairment (MCI), and mild stage Alzheimer disease (AD) dementia completed tests of cognition and self-report questionnaires about QOL and 3 kinds of cognitive complaints: cognitive difficulties, distress from cognitive difficulties, and believing you had more memory problems than most people. Bivariate, multivariable, and multivariate regression analyses assessed relationships between domains of QOL and each cognitive complaint. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249095PMC
October 2019
4 Reads

Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer's Disease: Post Hoc Analyses From a Randomized, Controlled, Clinical Trial of Patients Treated With Cholinesterase Inhibitors.

Alzheimer Dis Assoc Disord 2018 Jul-Sep;32(3):173-178

Allergan PLC, Madison, NJ.

Memantine extended release (ER) significantly outperformed placebo on co-primary endpoints of Clinician's Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus) and baseline to endpoint changes on the Severe Impairment Battery (SIB) in a 24-week, randomized trial (NCT00322153) in patients with moderate to severe Alzheimer's disease taking a cholinesterase inhibitor (ChEI). A post hoc analysis compared patients receiving memantine ER/ChEI to placebo/ChEI for time to onset of response and if the response was maintained (achieving improvement at weeks 8, 12, or 18 and maintaining through endpoint/week 24) on the SIB, the Neuropsychiatric Inventory (NPI), CIBIC-Plus, and Activities of Daily Living (ADL) using Fisher exact test. A second post hoc analysis compared percentages of patients for all possible combinations of 2 to 4 assessments with either no decline or clinically notable response using Wald χ. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110375PMC
May 2018
3 Reads

The Accuracy of INECO Frontal Screening in the Diagnosis of Executive Dysfunction in Frontotemporal Dementia and Alzheimer Disease.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):314-319

Departments of Neurology.

Introduction: Executive dysfunction is a common symptom in neurodegenerative disorders and is in need of easy-to-apply screening tools that might identify it. The aims of the present study were to examine some of the psychometric characteristics of the Brazilian version of the INECO frontal screening (IFS), and to investigate its accuracy to diagnose executive dysfunction in dementia and its accuracy to differentiate Alzheimer disease (AD) from the behavioral variant of frontotemporal dementia (bvFTD).

Methods: Patients diagnosed with bvFTD (n=18) and AD (n=20), and 15 healthy controls completed a neuropsychological battery, the Neuropsychiatric Inventory, the Cornell Scale for Depression in Dementia, the Clinical Dementia Rating, and the IFS. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000255DOI Listing
May 2018
6 Reads

Medicare Expenditures and Health Care Utilization in a Multiethnic Community-based Population With Dementia From Incidence to Death.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):320-325

Department of Neurology, Cognitive Neuroscience Division, Columbia University Medical Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain.

Introduction: While individuals live with dementia for many years, utilization and expenditures from disease onset through the end-of-life period have not been examined in ethnically diverse samples.

Methods: We used a multiethnic, population-based, prospective study of cognitive aging (Washington Heights-Inwood Columbia Aging Project) linked to Medicare claims to examine total Medicare expenditures and health care utilization among individuals with clinically diagnosed incident dementia from disease onset to death.

Results: High-intensity treatment (hospitalizations, life-sustaining procedures) was common and mean Medicare expenditures per year after diagnosis was $69,000. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215747PMC
October 2019
3 Reads

Recruiting the Oldest-old for Clinical Research.

Alzheimer Dis Assoc Disord 2018 May 4. Epub 2018 May 4.

Institute for Memory Impairments and Neurological Disorders.

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http://dx.doi.org/10.1097/WAD.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289893PMC
May 2018
2 Reads

Self-awareness of Driving Ability in the Healthy Elderly and Patients With Mild Cognitive Impairment (MCI).

Alzheimer Dis Assoc Disord 2018 Apr-Jun;32(2):107-113

Cognitive Disorders/Dementia Unit, 2nd Department of Neurology, National and Kapodistrian University of Athens, "Attikon" University Hospital.

Introduction: According to latest research, a percentage of cognitively impaired drivers fail to recognize their areas of weakness and overestimate their driving abilities.

Methods: Twenty-seven individuals with amnestic mild cognitive impairment (MCI) and 26 healthy elderly drivers participated in a driving simulator study. After the driving assessment, participants were asked to self-evaluate their performance in comparison with what they considered as average for people of similar age and educational level. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000254DOI Listing
April 2018
5 Reads

Effects of the Tailored Activity Program in Brazil (TAP-BR) for Persons With Dementia: A Randomized Pilot Trial.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):339-345

Drexel University, Philadelphia, PA.

Objectives: The objectives of this study were to evaluate the effects of the Tailored Activity Program-Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden.

Materials And Methods: A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care. Dyads were recruited from the community of Santos City, Brazil. Read More

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http://Insights.ovid.com/crossref?an=00002093-900000000-9942
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http://dx.doi.org/10.1097/WAD.0000000000000256DOI Listing
April 2018
17 Reads

Participant Satisfaction With Learning Alzheimer Disease Clinical Trial Results.

Alzheimer Dis Assoc Disord 2018 Oct-Dec;32(4):366-368

Institute for Memory Impairments and Neurological Disorders.

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http://dx.doi.org/10.1097/WAD.0000000000000258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195861PMC
October 2019
2.440 Impact Factor