Chem Biodivers 2022 Jun 29. Epub 2022 Jun 29.
University of Mianwali, Department of Chemistry/VC Office, VC Office, Department of Chemistry, University of Mianwali, Pakistan, Mianwali, PAKISTAN.
A sequence of 1,3,4-oxadiazole 2-thiol derivatives bearing various alkyl or aryl moieties was designed, synthesized, and characterized by modern spectroscopic methods to yield 17 compounds ( 6a - 6q ) which were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in search of 'lead' compounds for the treatment of Alzheimer disease (AD). The compounds 6q, 6p, 6k, 6o, and 6l showed inhibitory capability against AChE and BChE, with IC 50 values ranging from 11.730. Read More