112,394 results match your criteria Alzheimer Disease


Logopenic aphasia due to Lewy body disease dramatically improved with donepezil.

eNeurologicalSci 2020 Jun 8;19:100241. Epub 2020 May 8.

Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

•Pathological basis of primary progressive aphasia is heterogeneous.•Logopenic primary progressive aphasia can precede dementia with Lewy bodies (DLB).•Cholinesterase inhibitor can improve logopenic aphasia with DLB. Read More

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http://dx.doi.org/10.1016/j.ensci.2020.100241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235623PMC

The ubiquitous role of mitochondria in Parkinson and other neurodegenerative diseases.

AIMS Neurosci 2020 25;7(1):43-65. Epub 2020 Mar 25.

Department of Informatics, Ionian University, Plateia Tsirigoti 7, 49100, Corfu, Greece.

Orderly mitochondrial life cycle, plays a key role in the pathology of neurodegenerative diseases. Mitochondria are ubiquitous in neurons as they respond to an ever-changing demand for energy supply. Mitochondria constantly change in shape and location, feature of their dynamic nature, which facilitates a quality control mechanism. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242057PMC

Various Bioactivities of Secondary Metabolites Isolated from the Sponge from the Red Sea Coast of Egypt.

Turk J Pharm Sci 2020 Apr 24;17(2):127-135. Epub 2020 Apr 24.

Alexandria University, Faculty of Science, Department of Botany and Microbiology, Alexandria, Egypt.

Objectives: The present study revealed the presence of bioactive constituents in sponge (HES) extract collected from the Red Sea using skin and scuba diving.

Materials And Methods: Cytotoxicity was tested against hepatocellular carcinoma cell lines as a prescreening test.

Results: The HES extract had high contents of total phenolic compounds (0. Read More

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http://dx.doi.org/10.4274/tjps.galenos.2018.72677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227922PMC

Fat-1 expression enhance hippocampal memory in scopolamine-induced amnesia.

J Nutr Biochem 2020 Apr 8;82:108394. Epub 2020 Apr 8.

Departments of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015; Departments of Nephrology, School of Medicine, Chungnam National University, Daejeon 35015. Electronic address:

Omega-3 polyunsaturated fatty acids (PUFA) are critical for optimal brain health and are involved in psychiatric and neurological ailments. Here, we report the effects of higher endogenous omega-3 PUFA on memory impairment in the hippocampus by studying mice with transgenic expression of the fat-1 gene that converts omega-6 to omega-3 PUFA. We performed Y-maze and passive avoidance tests to evaluate the memory function of fat-1 mice treated with scopolamine. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108394DOI Listing

HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis.

PLoS Biol 2020 May 26;18(5):e3000660. Epub 2020 May 26.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.

Increased life expectancy of patients diagnosed with HIV in the current era of antiretroviral therapy is unfortunately accompanied with the prevalence of HIV-associated neurocognitive disorders (HANDs) and risk of comorbidities such as Alzheimer-like pathology. HIV-1 transactivator of transcription (Tat) protein has been shown to induce the production of toxic neuronal amyloid protein and also enhance neurotoxicity. The contribution of astrocytes in Tat-mediated amyloidosis remains an enigma. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000660DOI Listing

Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy.

Alzheimer Dis Assoc Disord 2020 May 22. Epub 2020 May 22.

Rush Alzheimer's Disease Center.

Purpose: Emerging evidence suggests that limbic-predominant age-related TAR DNA-binding protein-43 (TDP-43) encephalopathy impacts domain-specific literacy, a complex ability not assessed in traditional cognitive evaluations. We examined longitudinal profiles of financial and health literacy in relation to limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC).

Participants: A total of 275 community-dwelling older persons who had completed annual literacy assessments, died and undergone brain autopsy. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000389DOI Listing

The β-secretase enzyme BACE1: A biochemical enigma for Alzheimer's disease.

CNS Neurol Disord Drug Targets 2020 May 26. Epub 2020 May 26.

North Carolina State University, North Carolina. United States.

Beta site amyloid precursor protein cleaving enzyme 1 (BACE1) is a rational target in Alzheimer's disease (AD) drug development due to its role in amyloidogenic cleavage of Amyloid precursor protein (APP) in generating Amyloid β (Aβ). This β-secretase cleaves not only Amyloid precursor protein (APP) and its homologues but also small series of substrate including neuregulin and β subunit of voltage gated sodium channel that play a very important role in the development and normal function of the brain. Moreover, BACE1 is modulated at the post translational level by several factors that are associated with both physiological and pathological functions. Read More

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http://dx.doi.org/10.2174/1871527319666200526144141DOI Listing

Recent trends in mental illness and omega-3 fatty acids.

J Neural Transm (Vienna) 2020 May 25. Epub 2020 May 25.

Department of Neuropsychiatry, Unit of Translation Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.

Although it is clear that nutrition affects physical and metabolic functions in humans, the importance of nutrition in mental illness has often been overlooked. Following a report by Hibbeln (Lancet 351:1213, 1998) published in The Lancet, which suggested that depression rates and fish consumption were inversely correlated, the relationships between a variety of nutritional/epidemiological treatments and neuropsychiatric disorders have received increased attention. In particular, many studies have been conducted on the omega-3 fatty acid mechanism of action in pathophysiological aspects of various neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1007/s00702-020-02212-zDOI Listing

Blood Pressure and Risks of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of 209 Prospective Studies.

Hypertension 2020 May 26:HYPERTENSIONAHA12014993. Epub 2020 May 26.

Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, China (X.-N.S., Q.D., J.-T.Y.).

Controversies persist regarding the association between blood pressure (BP) and the risks of cognitive impairment and dementia due to inconsistent definitions of BP exposure and varying population characteristics. Here, we searched PubMed and performed a meta-analysis of the influence of BP exposure on the risks of cognitive disorders in prospective studies. Dose-response analyses were performed to illustrate the existence of linear/nonlinear relationships. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.14993DOI Listing

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.

Neurobiol Aging 2020 Apr 29;93:61-68. Epub 2020 Apr 29.

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China. Electronic address:

Genome-wide association studies have identified many loci associated with Alzheimer's dementia. However, these variants only explain part of the heritability of Alzheimer's disease (AD). As genetic epistasis can be a major contributor to the "missing heritability" of AD, we conducted genome-wide epistasis screening for AD pathologies in 2 independent cohorts. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.025DOI Listing

Anterior EEG slowing in dementia with Lewy bodies: a multicenter European cohort study.

Neurobiol Aging 2020 Apr 29;93:55-60. Epub 2020 Apr 29.

Department of Neuroscience, Imaging and Clinical Science, and Aging Research Centre, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy. Electronic address:

Electroencephalography (EEG) slowing with prealpha dominant frequency (DF) in posterior derivations is a biomarker for dementia with Lewy bodies (DLB) diagnosis, in contrast with Alzheimer's disease (AD). However, an intrasubject re-evaluation of the original data, which contributed to the identification of EEG DLB biomarker, showed that DF was slower in anterior than posterior derivations. We suppose this anterior-posterior gradient of DF slowing could arise in DLB from a thalamocortical dysrhythmia, differently involving the anterior and posterior cortical areas, and correlating with cognitive impairment (Mini-Mental State Examination). Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.023DOI Listing

The anti-Alzheimer effect of telmisartan in a hyperglycemic ovariectomized rat model; role of central angiotensin and estrogen receptors.

Food Chem Toxicol 2020 May 22:111441. Epub 2020 May 22.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. Electronic address:

The central renin angiotensin system (RAS) is implicated in Alzheimer's disease (AD). Here, induction of experimental AD simulation was performed by D-galactose (D-Gal) injection to ovariectomized (OVX) rats fed on high fat high fructose diet (HFFD). Telmisartan administration to OVX/HFFD/D-Gal rats lowered the expression of hippocampal angiotensin 1 and 2 receptors and glucose transporter 2 in addition to lowering of the peripheral and central glucose levels. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111441DOI Listing

The effects of melatonin, serotonin, tryptophan and NAS on the biophysical properties of DPPC monolayers.

Biochim Biophys Acta Biomembr 2020 May 22:183363. Epub 2020 May 22.

Department of Physics and Astronomy, University of Waterloo, Waterloo, Canada; Department of Biology, University of Waterloo, Waterloo, Canada; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Canada. Electronic address:

Melatonin is a neurohormone that has been shown to be protective in Alzheimer's diseases against amyloid-β (Aβ) toxicity, which involves interaction of Aβ with neuronal membrane. Non-specific interactions of melatonin with cell membrane may play a physiological role in this process by preserving membrane fluidity. In the brain, melatonin is derived from the amino acid tryptophan through a pathway that includes serotonin and N-acetylserotonin (NAS). Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183363DOI Listing

Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.

Autophagy 2020 May 25:1-19. Epub 2020 May 25.

Departments of Pharmacology and Toxicology, University of Alabama School of Medicine , Birmingham, AL, USA.

Stroke is a leading cause of death and disability. The pathophysiological mechanisms associated with stroke are very complex and not fully understood. Lysosomal function has a vital physiological function in the maintenance of cellular homeostasis. Read More

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http://dx.doi.org/10.1080/15548627.2020.1761219DOI Listing

Orthostatic blood pressure recovery is associated with the rate of cognitive decline and mortality in clinical Alzheimer's disease.

J Gerontol A Biol Sci Med Sci 2020 May 25. Epub 2020 May 25.

Radboud university medical center, Donders Institute for Brain Cognition and Behaviour, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Nijmegen, The Netherlands.

Background: Impaired recovery of blood pressure (BP) after standing has been shown to be related to cognitive function and mortality in people without dementia, but its role in people with Alzheimer's disease (AD) is unknown. The aim of this study was to investigate the association of the orthostatic BP response with cognitive decline and mortality in AD.

Methods: In this post-hoc analysis of a randomized controlled trial (Nilvad), we measured the beat-to-beat response of BP upon active standing in mild-to-moderate AD. Read More

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http://dx.doi.org/10.1093/gerona/glaa129DOI Listing

Identification of amyloid antibodies for Alzheimer disease - immunotherapy.

Arch Physiol Biochem 2020 May 25:1-8. Epub 2020 May 25.

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

The current study identified the specific antibodies that recognise amyloid protein for Alzheimer disease - immunotherapy. The immune-selection of random sequences from a phage display library and sequencing to obtain the random 12 amino acids peptide library for each antibody, and then we analysed these peptides for unique and common sequences, relation to Aβ42 sequence and shape and pattern of the amino acid reaction to the antibody to predict the epitopes. Data obtained for 4G8 showed that, the sequence segment related to the putative epitope of 4G8 was LVFFAED. Read More

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http://dx.doi.org/10.1080/13813455.2020.1767147DOI Listing

Diagnostic utility and characteristics of CT-based attenuation correction in brain perfusion SPECT/CT in predicting the exacerbation of Alzheimer changes from mild cognitive impairment utilizing voxel-based statistical analysis in comparison with Chang's method.

Ann Nucl Med 2020 May 24. Epub 2020 May 24.

Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-0022, Japan.

Objective: We examined the diagnostic value of brain perfusion single-photon emission computed tomography (SPECT) using voxel-based statistical analysis with CT-based attenuation correction (CT-AC) by comparing it to that with Chang's AC in mild cognitive impairment (MCI) patients and attempted to locate brain areas that are good indicators predicting the progression of MCI.

Methods: Twenty-six individuals matched for age, educational background and initial Mini-Mental State Examination (MMSE) score of more than 24 underwent SPECT with N-isopropyl-4-[I]iodoamphetamine and were assigned to 2 groups: the stable MCI (S-MCI) group comprising 11 subjects who maintained their MMSE score (mean 27.0) during at least a 1-year follow-up period (mean 37. Read More

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http://dx.doi.org/10.1007/s12149-020-01477-4DOI Listing

Potentiation of anti-Alzheimer activity of curcumin by probiotic Lactobacillus rhamnosus UBLR-58 against scopolamine-induced memory impairment in mice.

Naunyn Schmiedebergs Arch Pharmacol 2020 May 25. Epub 2020 May 25.

Department of Pharmacology, SSR College of Pharmacy, SSR Memorial Trust, Silvassa, Dadra and Nagar Haveli, 396230, India.

Curcumin, a major component of Indian saffron through clinical studies, revealed its neuroprotective effect in neurodegenerative diseases. However, it has not been utilized alone orally due to its low bioavailability. There are certain strategies to overcome the drawbacks such as poor absorption and low aqueous solubility. Read More

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http://dx.doi.org/10.1007/s00210-020-01904-3DOI Listing

The role of mitochondrial impairment on Alzheimer´s disease neurodegeneration: the Tau connection.

Curr Neuropharmacol 2020 May 24. Epub 2020 May 24.

Laboratory of Neurodegenerative diseases, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago. Chile.

Accumulative evidence has shown that mitochondrial dysfunction plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial impairment actively contributes to the synaptic and cognitive failure that characterizes AD. The presence of soluble pathological forms of tau like hyperphosphorylated at Ser396 and Ser404 and cleaved at Asp421 by caspase 3, negatively impacts mitochondrial bioenergetics, transport, and morphology in neurons. Read More

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http://dx.doi.org/10.2174/1570159X18666200525020259DOI Listing

The Anterior-posterior Functional Connectivity Disconnection in the Elderly with Subjective Memory Impairment and Amnestic Mild Cognitive Impairment.

Curr Alzheimer Res 2020 May 24. Epub 2020 May 24.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875. China.

Background: Subjective memory impairment (SMI) may tremendously increase the risk of Alzheimer's disease (AD). The full understanding of the neuromechanism of SMI will shed light on the early intervention of AD.

Methods: In the current study, 23 healthy controls (HC), 22 SMI subjects and 24 amnestic mild cognitive impairment (aMCI) subjects underwent the comprehensive neuropsychological assessment and the resting-state functional magnetic resonance imaging scan. Read More

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http://dx.doi.org/10.2174/1567205017666200525015017DOI Listing

Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

Lancet Neurol 2020 May 20. Epub 2020 May 20.

Department of Neurology and Alzheimer Center, VU University Medical Center Amsterdam, Amsterdam, Netherlands.

People with type 2 diabetes are at an increased risk of cognitive impairment and dementia (including Alzheimer's disease), as well as subtle forms of cognitive dysfunction. Current diabetes guidelines recommend screening for cognitive impairment in groups at high risk and providing guidance for diabetes management in patients with diabetes and cognitive impairment. Yet, no disease-modifying treatment is available and important questions remain about the mechanisms underlying diabetes-associated cognitive dysfunction. Read More

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http://dx.doi.org/10.1016/S1474-4422(20)30139-3DOI Listing

Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice.

Aging (Albany NY) 2020 May 22;12. Epub 2020 May 22.

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden.

A major challenge in the health care system is the lack of knowledge about the possible harmful effects of multiple drug treatments in old age. The present study aims to characterize a mouse model of polypharmacy, in order to investigate whether long-term exposure to multiple drugs could lead to adverse outcomes. To this purpose we selected five drugs from the ten most commonly used by older adults in Sweden (metoprolol, paracetamol, aspirin, simvastatin and citalopram). Read More

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http://dx.doi.org/10.18632/aging.103315DOI Listing

Biocompatible nanovesicular drug delivery systems with targeting potential for autoimmune diseases.

Curr Pharm Des 2020 May 23. Epub 2020 May 23.

Delhi Pharmaceutical Sciences and Research University, New Delhi. India.

Autoimmune diseases are collectively addressed as chronic conditions initiated by loss of one's immunological tolerance, where body treats its own cells as foreigners or self-antigens. These hay-wired antibodies or immunologically capable cells lead to variety of disorders like rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, multiple sclerosis and recently included neurodegenerative diseases like Alzheimer's, Parkinsonism and testicular cancer triggered T-cells induced autoimmune response in testes and brain. Conventional treatments for autoimmune diseases possess several downsides due to unfavourable pharmacokinetic behaviour of drug, reflected by low bioavailability, rapid clearance, offsite toxicity, restricted targeting ability and poor therapeutic outcomes. Read More

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http://dx.doi.org/10.2174/1381612826666200523174108DOI Listing

Tenuifolin Attenuates Amyloid-β42-Induced Neuroinflammation in Microglia Through the NF-κB Signaling Pathway.

J Alzheimers Dis 2020 May 19. Epub 2020 May 19.

Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, P.R. China.

Background: Inflammation and oxidative stress are believed to play an important role in the pathogenesis of Alzheimer's disease (AD). Tenuifolin (TEN) is a natural neuroprotective compound extracted from Polygala tenuifolia Willd, which may improve cognitive symptoms.

Objective: This study was designed to evaluate the protective effect of TEN on inflammatory and oxidative stress induced by amyloid-β (Aβ)42 oligomers in BV2 cells, and to explore the underlying mechanisms. Read More

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http://dx.doi.org/10.3233/JAD-200077DOI Listing

Effect of Aβ oligomers on neuronal APP triggers a vicious cycle leading to the propagation of synaptic plasticity alterations to healthy neurons.

J Neurosci 2020 May 22. Epub 2020 May 22.

Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences, GIN, 38000 Grenoble, France

Alterations of excitatory synaptic function are the strongest correlate to the pathological disturbance of cognitive ability observed in the early stages of Alzheimer disease (AD). This pathological feature is driven by Amyloid-β oligomers (Aβo) and propagates from neuron to neuron. Here, we investigated the mechanism by which Aβo affect the function of synapses and how these alterations propagate to surrounding healthy neurons. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2501-19.2020DOI Listing

Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease.

Bioorg Chem 2020 May 12;100:103917. Epub 2020 May 12.

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address:

7-O-galloyltricetiflavan (GTF), a natural flavonoid, is known to exert anti-oxidation and neuroprotective activity, which are related to the prevention of Alzheimer's disease (AD). In this study, three series of GTF hybrids have been designed, synthesized and evaluated as multifunctional agents for treatment AD. The biological assays indicated that most of them showed strong inhibitory effect on self-induced β-amyloid (Aβ) aggregation, and a significant ability to inhibit ChEs. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103917DOI Listing

Recognition memory impairments and amyloid-beta deposition of the retrosplenial cortex at the early stage of 5XFAD mice.

Physiol Behav 2020 May 19:112891. Epub 2020 May 19.

Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address:

Early diagnosis and treatment of AD are critical for delaying its progression. The present study, therefore, examined the cognitive status and neuropathological characteristics of 4-month-old 5X familial AD (5XFAD) transgenic (Tg) mice, as an early stage of AD animal model. The novel object recognition task was performed with retention tests at varying intervals (i. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.112891DOI Listing

Physical inactivity is liable to the increased cardiovascular risk and impaired cognitive profile.

Curr Alzheimer Res 2020 May 22. Epub 2020 May 22.

Universidade Federal de Viçosa, Viçosa (Minas Gerais). Brazil.

A sedentary life-style is a significant public health issue. It increases the incidence of type-2 diabetes mellitus (DM2) and systemic arterial hypertension (SAH), which in turn may impair physical and mental health. In fact, disrupted glucose metabolism is one of the characteristics of Alzheimer's dementia, and it is often dubbed as type-3 diabetes. Read More

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http://dx.doi.org/10.2174/1567205017666200522205646DOI Listing

Approaches To Optimizing Dantrolene Neuroprotection For The Treatment Of Alzheimer's Disease.

Curr Alzheimer Res 2020 May 22. Epub 2020 May 22.

Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104. United States.

Alzheimer's Disease (AD), a neurodegenerative disorder with high incidence and mortality, is leading its way to the top of the list of the deadliest diseases [1], without an effective disease-modifying drug. Ca2+ dysregulation, specifically abnormal release of Ca2+ by over activated ryanodine receptor (RyR), has been increasingly considered as an alternative upstream mechanism in AD pathology. Consequently, dantrolene, a RyR antagonist and FDA approved drug to treat malignant hyperthermia and chronic muscle spasms, has been shown to ameliorate memory loss in AD transgenic mice. Read More

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http://dx.doi.org/10.2174/1567205017666200522204722DOI Listing

Associations of Plasma BACE1 level and BACE1 C786G Gene Polymorphism with Cognitive Functions in Patients with type 2 Diabetes: a Crosssectional study.

Curr Alzheimer Res 2020 May 22. Epub 2020 May 22.

Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing. China.

Background: β-Site APP-cleaving enzyme 1 (BACE1) is a key enzyme involved in the pathophysiology of Type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI). We aimed to investigate the potential associations of plasma BACE1 levels and BACE1 gene polymorphism with different cognitive performances in T2DM patients with MCI.

Methods: The recruited 186 T2DM subjects were divided into 92 MCI group and 94 healthy-cognition controls, according to the Montreal Cognitive Assessment (MoCA) scores. Read More

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http://dx.doi.org/10.2174/1567205017666200522210957DOI Listing

Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.

Curr Neurovasc Res 2020 05 22. Epub 2020 May 22.

Elysium Health Center, Gaziantep. Turkey.

1. Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus infectious disease 2019 (COVID-19), which was first reported in Wuhan, China, in late December, 2019. Despite the tremendous efforts to control the disease, SARS-CoV-2 has infected 1,5 million people and caused the death of more than a hundred thousand people across the globe as of writing. Read More

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http://dx.doi.org/10.2174/1567202617666200522220509DOI Listing

Diversity of Molecular Factors in Alzheimer's Disease.

Curr Alzheimer Res 2020 ;17(3):205-207

Departments of Psychiatry, and of Medical & Molecular Genetics, Indiana University School of Medicine, Stark Neuroscience Research Institute, Indianapolis, IN 46202, United States.

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http://dx.doi.org/10.2174/156720501703200518081524DOI Listing
January 2020

Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up-regulating SIRT1.

Brain Behav 2020 May 22:e01655. Epub 2020 May 22.

The First Affiliated Hospital, University of South China, Hengyang, China.

Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disease. It can lead to progressive cognitive impairment, memory loss, and behavioral alterations. So far, the exact cellular and molecular mechanisms underlying this disorder remain unclear. Read More

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http://dx.doi.org/10.1002/brb3.1655DOI Listing

Moderators of Cognitive Outcomes from an Exercise Program in People with Mild to Moderate Dementia.

J Am Geriatr Soc 2020 May 22. Epub 2020 May 22.

Nuffield Department of Orthopaedics Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background/objectives: Our aim was to estimate whether baseline participant variables were able to moderate the effect of an exercise intervention on cognition in patients with mild to moderate dementia.

Design: Subgroup analysis of a multicenter pragmatic randomized controlled trial.

Setting: Community-based gym/rehabilitation centers. Read More

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http://dx.doi.org/10.1111/jgs.16552DOI Listing

Pick's disease: clinicopathologic characterization of 21 cases.

J Neurol 2020 May 21. Epub 2020 May 21.

Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.

Background: Pick's disease (PiD) is a unique subtype of frontotemporal lobar degeneration characterized pathologically by aggregates of 3-Repeat tau. Few studies have examined the clinical variability and disease progression in PiD. We describe the clinical features, neuropsychological profiles and coexistent pathologies in 21 cases of autopsy-confirmed PiD. Read More

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http://dx.doi.org/10.1007/s00415-020-09927-9DOI Listing

Findings of a Pilot Study Investigating the Effects of Mediterranean Diet and Aerobic Exercise on Cognition in Cognitively Healthy Older People Living Independently within Aged-Care Facilities: The Lifestyle Intervention in Independent Living Aged Care (LIILAC) Study.

Curr Dev Nutr 2020 May 18;4(5):nzaa077. Epub 2020 Apr 18.

Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia.

Background: Cognitive decline and Alzheimer disease are more prevalent in our aging population. Modifiable risk factors, such as diet and sedentary lifestyle, have been proposed as key to potentially ameliorating cognitive decline. Both exercise and Mediterranean diet (MedDiet) have been linked to reduced levels of cardiovascular disease and other comorbidities. Read More

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http://dx.doi.org/10.1093/cdn/nzaa077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228438PMC

Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils.

Proc Natl Acad Sci U S A 2020 May 21. Epub 2020 May 21.

Department of Biochemistry and Structural Biology, Lund University, 221 00 Lund, Sweden;

The nucleation of Alzheimer-associated Aβ peptide monomers can be catalyzed by preexisting Aβ fibrils. This leads to autocatalytic amplification of aggregate mass and underlies self-replication and generation of toxic oligomers associated with several neurodegenerative diseases. However, the nature of the interactions between the monomeric species and the fibrils during this key process, and indeed the ultrastructural localization of the interaction sites have remained elusive. Read More

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http://dx.doi.org/10.1073/pnas.1918481117DOI Listing

Neuropsychiatric Aspects of Alzheimer Dementia: From Mechanism to Treatment.

Authors:
Milap A Nowrangi

Psychiatr Clin North Am 2020 Jun 22;43(2):383-397. Epub 2020 Apr 22.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Developing disease-modifying treatments for Alzheimer dementia requires innovative approaches to identify novel biological targets during the course of the disease. Treatment development for the neuropsychiatric symptoms of Alzheimer may benefit from a mechanistic approach to treatment. There has been progress in identifying mild forms of behavioral impairment along the Alzheimer spectrum that may lead to additional insights into progression to dementia as well as the fundamental mechanisms of the symptoms. Read More

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http://dx.doi.org/10.1016/j.psc.2020.02.012DOI Listing

Disease-Specific Changes in Reelin Protein and mRNA in Neurodegenerative Diseases.

Cells 2020 05 19;9(5). Epub 2020 May 19.

Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, 08028 Barcelona, Spain.

Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during neurodegeneration in Alzheimer´s disease (AD) and in aging. Thus, changes in levels of full-length Reelin and Reelin fragments have been revealed in cerebrospinal fluid (CSF) and in post-mortem brains samples of AD patients with respect to non-AD patients. Read More

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http://dx.doi.org/10.3390/cells9051252DOI Listing

Ameliorating Activity of Ishige Okamurae on the Amyloid Beta Induced Cognitive Deficits and Neurotoxicity Through Regulating ERK, p38 MAPK and JNK Signaling in Alzheimer's Disease-Like Mice Model.

Authors:

Mol Nutr Food Res 2020 May 21:e1901220. Epub 2020 May 21.

Scope: Alzheimer's disease (AD) has been associated with amyloid beta peptide (Aβ ) accumulation in brains, which induces neurotoxicity and cognitive impairment. We investigated the effects of Ishige okamurae, an edible brown algae, on Aβ -induced cognitive impairment and neuronal toxicity. The aim of this study was to determine the molecular mechanisms responsible for Ishige okamurae extracts (IOE) mediating anti-AD effects. Read More

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http://dx.doi.org/10.1002/mnfr.201901220DOI Listing

Genotype concordance and polygenic risk score estimation across consumer genetic testing data.

Ann Hum Genet 2020 May 21. Epub 2020 May 21.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York.

The consumer genomics industry is steadily growing and delivering genetic information to over 10 million individuals. Yet, the implications of using data from different services remain unclear. We investigated the genotyped sites, concordance, and genetic risk estimation using data from three consumer services-two single nucleotide polymorphism (SNP)-array based and one sequencing based. Read More

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http://dx.doi.org/10.1111/ahg.12389DOI Listing

High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities.

Br J Pharmacol 2020 May 20. Epub 2020 May 20.

Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, Seoul National University, Seoul, 08826, Republic of Korea.

Background And Purpose: Although diabetes mellitus (DM) is an important risk factor for Alzheimer's disease (AD), the detailed mechanism by which DM regulates amyloid beta (Aβ) processing is still unclear. The increment of residence time of amyloid precursor protein (APP) in endosomes is critical for Aβ production and that DM causes endosomal dysregulation. Therefore, this study aims to examine the effects of high glucose on APP-producing endosomes and its related signaling pathways. Read More

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http://dx.doi.org/10.1111/bph.15131DOI Listing

Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome.

Alzheimers Dement (Amst) 2020 17;12(1):e12023. Epub 2020 Apr 17.

Institute for Translational Research Department of Pharmacology and Neuroscience University of North Texas Health Science Center Fort Worth Texas USA.

Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS).

Methods: Plasma samples were obtained from 398 members of a community-based cohort of adults with DS. A total of n = 186 participants were determined to be non-demented and without mild cognitive impairment (MCI) at baseline and throughout follow-up; n = 50 had prevalent MCI; n = 42 had prevalent AD. Read More

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http://dx.doi.org/10.1002/dad2.12023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233426PMC

Amyloid accumulation in Down syndrome measured with amyloid load.

Alzheimers Dement (Amst) 2020 16;12(1):e12020. Epub 2020 Apr 16.

University of Wisconsin-Madison Waisman Center Madison Wisconsin.

Introduction: Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load ( ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change.. Read More

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http://dx.doi.org/10.1002/dad2.12020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233422PMC

Down syndrome: Distribution of brain amyloid in mild cognitive impairment.

Alzheimers Dement (Amst) 2020 17;12(1):e12013. Epub 2020 Apr 17.

Department of Pediatrics University of California Irvine Medical Center Orange California.

Introduction: Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.

Methods: 18F-AV-45 (florbetapir) positron emission tomography (PET) data were collected to analyze amyloid burden in 58 participants clinically classified as cognitively stable (CS) or MCI-DS and 12 longitudinal CS participants. Read More

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http://dx.doi.org/10.1002/dad2.12013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233421PMC

Effectiveness and Safety of Acupuncture for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Front Aging Neurosci 2020 6;12:98. Epub 2020 May 6.

Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

The effects of acupuncture on Alzheimer's disease (AD) outcomes remain controversial. The aim of this review was to evaluate the effectiveness and safety of acupuncture for the treatment of AD. PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials, Chinese BioMedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, and Wanfang Data were searched to identify relevant randomized controlled trials from inception to January 19, 2019. Read More

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http://dx.doi.org/10.3389/fnagi.2020.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218057PMC
May 2020
2.843 Impact Factor

[The cognitive-behavioural impact of hypertension].

Hipertens Riesgo Vasc 2020 May 17. Epub 2020 May 17.

Unidad Corazón-Cerebro, Servicio de Prevención Cardiovascular, ICBA-Instituto Cardiovascular, Buenos Aires, Argentina.

Arterial hypertension is considered the main modifiable vascular risk factor that causes silent damage to brain vessels. This vascular brain injury could be the common nucleus that justifies the cognitive (cognitive impairment, dementia and Alzheimer's disease) and behavioural symptoms (late-life depression) of target organ damage mediated-hypertension. Incomplete knowledge about the complex pathophysiology that links hypertension with cognitive-behavioural changes is overlooking brain involvement and underestimating cardio and cerebrovascular risk. Read More

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http://dx.doi.org/10.1016/j.hipert.2020.04.003DOI Listing

Resurrecting the Mysteries of Big Tau.

Trends Neurosci 2020 May 17. Epub 2020 May 17.

Drexel University College of Medicine, Department of Neurobiology and Anatomy, 2900 Queen Lane, Philadelphia, PA 19129, USA. Electronic address:

Tau, a microtubule-associated protein that modifies the dynamic properties and organization of microtubules in neurons and affects axonal transport, shows remarkable heterogeneity, with multiple isoforms (45-65 kDa) generated by alternative splicing. A high-molecular-weight (HMW) isoform (110 kDa) that contains an additional large exon termed 4a was discovered more than 25 years ago. This isoform, called Big tau, is expressed mainly in the adult peripheral nervous system (PNS), but also in adult neurons of the central nervous system (CNS) that extend processes into the periphery. Read More

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http://dx.doi.org/10.1016/j.tins.2020.04.007DOI Listing

Association between benzodiazepine use and development of dementia.

Med Clin (Barc) 2020 May 17. Epub 2020 May 17.

Navarre Health Service, IdiSNA, Navarra Institute for Health Research, Spain.

Objective: To evaluate the association between use of benzodiazepines and incident dementia.

Methods: Analytical prospective nested case-control study for which the Spanish database for pharmacoepidemiological research in primary care (BIFAP) of the Spanish Agency of Medicines and Medical Devices (AEMPS) was used. A total of 15,212 subjects diagnosed with dementia of the Alzheimer type and 62,397 controls were identified. Read More

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http://dx.doi.org/10.1016/j.medcli.2020.02.006DOI Listing

Characterization of a new molecule capable of inhibiting several steps of the amyloid cascade in Alzheimer's disease.

Neurobiol Dis 2020 May 18;141:104938. Epub 2020 May 18.

Laboratory of Neurophysiology, Department of Physiology, Universidad de Concepción, Concepción, Chile. Electronic address:

Introduction: Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Existent therapies are directed at alleviating some symptoms, but are not effective in altering the course of the disease.

Methods: Based on our previous study that showed that an Aβ-interacting small peptide protected against the toxic effects of amyloid-beta peptide (Aβ), we carried out an array of in silico, in vitro, and in vivo assays to identify a molecule having neuroprotective properties. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.104938DOI Listing