3 results match your criteria Alzheimer\'s & dementia Amsterdam Netherlands[Journal]

  • Page 1 of 1

The Role of nAChR and Calcium Signaling in Pancreatic Cancer Initiation and Progression.

Cancers (Basel) 2015 Jul 31;7(3):1447-71. Epub 2015 Jul 31.

Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.

Pancreatic cancer shows a strong correlation with smoking and the current therapeutic strategies have been relatively ineffective in improving the survival of patients. Efforts have been made over the past many years to understand the molecular events that drive the initiation and progression of pancreatic cancer, especially in the context of smoking. It has become clear that components of tobacco smoke not only initiate these cancers, especially pancreatic ductal adenocarcinomas (PDACs) through their mutagenic properties, but can also promote the growth and metastasis of these tumors by stimulating cell proliferation, angiogenesis, invasion and epithelial-mesenchymal transition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers7030845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586778PMC
July 2015
2 Reads

Protein tyrosine phosphatases in pathological process.

Front Biosci (Landmark Ed) 2015 Jan 1;20:377-88. Epub 2015 Jan 1.

Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland.

Protein tyrosine phosphatases (PTPs) modulate the cellular level of tyrosine phosphorylation under normal and pathological conditions, and thus exert either stimulatory or inhibitory effect on signal transduction. Hence, PTPs are potential pharmacological targets for novel drugs being developed in order to treat numerous pathologies including cancer. For example, PTPs have been found to play a key role in pathogenesis of autoimmune disorders, allergic response, cardiovascular or neurodegenerative diseases, among others Alzheimer\'s disease. Read More

View Article

Download full-text PDF

Source
January 2015
4 Citations

New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.

Neuro Endocrinol Lett 2008 Oct;29(5):755-8

Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.

Two drugs were tested using electrochemical biosensor with immobilized acetylcholinesterase (AChE). The first was commercialized drug tacrine (known also as Cognex) used for treatment of cognitive manifestation of Alzheimer\'s disease (AD). The second one was its 7-methoxy derivate (7-MEOTA) that has not been marketed. Read More

View Article

Download full-text PDF

Source
October 2008
19 Reads
  • Page 1 of 1