109,381 results match your criteria Alzheimer's Research & Therapy [Journal]


Identification of a novel BACE1 inhibitor, timosaponin A-III, for treatment of Alzheimer's disease by a cell extraction and chemogenomics target knowledgebase-guided method.

Phytomedicine 2020 May 24;75:153244. Epub 2020 May 24.

Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China. Electronic address:

Background: Rhizoma Anemarrhenae (RA) has been conventionally used for treatment of Alzheimer's disease (AD) in Traditional Chinese Medicine, and thus, the active components from RA can be screened.

Purpose: This research aimed to identify the active components of RA and their targets and further clarify the molecular mechanisms underlying its anti-AD activity.

Methods: First, the potential active compounds from RA were screened by neurocyte extraction and micro-dialysis methods. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153244DOI Listing

Role of mtDNA disturbances in the pathogenesis of Alzheimer's and Parkinson's disease.

DNA Repair (Amst) 2020 May 21;91-92:102871. Epub 2020 May 21.

Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Kateřinská 32, 121 08 Prague 2, Czech Republic; BIOCEV, First Faculty of Medicine, Charles University, Kateřinská 32, 121 08 Prague 2, Czech Republic; Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Dejvice, Czech Republic. Electronic address:

Neurodegenerative diseases (e.g. Alzheimer's and Parkinson's disease) are becoming increasingly problematic to healthcare systems. Read More

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http://dx.doi.org/10.1016/j.dnarep.2020.102871DOI Listing

The pivotal role of SUMO-1-JNK-Tau axis in an in vitro model of oxidative stress counteracted by the protective effect of curcumin.

Biochem Pharmacol 2020 Jun 2:114066. Epub 2020 Jun 2.

Laboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, Italy; Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran; Department of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy. Electronic address:

Oxidative stress is a toxic cellular condition, strictly related to inflammation and known to be a common feature of many neurodegenerative diseases. The imbalanced redox state modifies several molecular processes including protein SUMOylation, JNK and Tau protein activation, important actors in Alzheimer's disease. In this study, we showed a strong interaction among SUMO-1-JNK-Tau proteins and their molecular targets in an in vitro model (SHSY5Y cell line) of oxidative stress in which a significant reduction of cell viability and an augmented cell death was induced by increased doses of H2O2. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114066DOI Listing

Quantile graphs for EEG-based diagnosis of Alzheimer's disease.

PLoS One 2020 5;15(6):e0231169. Epub 2020 Jun 5.

Department of Biostatistics, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

Known as a degenerative and progressive dementia, Alzheimer's disease (AD) affects about 25 million elderly people around the world. This illness results in a decrease in the productivity of people and places limits on their daily lives. Electroencephalography (EEG), in which the electrical brain activity is recorded in the form of time series and analyzed using signal processing techniques, is a well-known neurophysiological AD biomarker. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231169PLOS

Performance gains with Compute Unified Device Architecture-enabled eddy current correction for diffusion MRI.

Neuroreport 2020 Jul;31(10):746-753

Imaging and Phenotyping Laboratory, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, NSW.

Correcting for eddy currents, movement-induced distortion and gradient inhomogeneities is imperative when processing diffusion MRI (dMRI) data, but is highly computing resource-intensive. Recently, Compute Unified Device Architecture (CUDA) was implemented for the widely-used eddy-correction software, 'eddy', which reduces processing time and allows more comprehensive correction. We investigated processing speed, performance and compatibility of CUDA-enabled eddy-current correction processing compared to commonly-used non-CUDA implementations. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001475DOI Listing

Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation.

FASEB J 2020 Jun 5. Epub 2020 Jun 5.

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Japan.

Metabolic changes in sulfatides and other sulfated glycans have been related to various diseases, including Alzheimer's disease (AD). However, the importance of polyunsaturated fatty acids (PUFA) in sulfated lysosomal substrate metabolism and its related disorders is currently unknown. We investigated the effects of deficiency or supplementation of PUFA on the metabolism of sulfatides and sulfated glycosaminoglycans (sGAGs) in sulfatide-rich organs (brain and kidney) of mice. Read More

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http://dx.doi.org/10.1096/fj.202000030RRDOI Listing

Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.

Aging (Albany NY) 2020 Jun 5;12. Epub 2020 Jun 5.

Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.

The present study was designed to follow neuroinflammation after ischemic brain injury in the long-term survival rat model. Immunohistochemistry was performed 2 years after 10 min global brain ischemia due to cardiac arrest. For the visualization of the cellular inflammatory reaction microglial marker Iba1 and astrocyte marker GFAP were used. Read More

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http://dx.doi.org/10.18632/aging.103411DOI Listing

(-)-o-[ C]methyl-trans-decalinvesamicol ((-)-[ C]OMDV) as a PET ligand for the vesicular acetylcholine transporter.

Synapse 2020 Jun 5:e22176. Epub 2020 Jun 5.

Division of Tracer Kinetics, Advanced Science Research Center, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

To develop a PET imaging agent to visualize brain cholinergic neurons and synaptic changes caused by Alzheimer's disease, (-)- and (+)-o-[ C]methyl-trans-decalinvesamicol ([ C]OMDV) were isolated and investigated for differences in not only their binding affinity and selectivity to vesicular acetylcholine transporter (VAChT) but also their in vivo activities. [ C]OMDV has a high binding affinity for VAChT both in vitro and in vivo. Racemic OMDV and o-trimethylstannyl-trans-decalinvesamicol (OTDV), which are precursors for synthesis of [ C]OMDV, were separated into (-)-optical isomers ((-)-OMDV and (-)-OTDV) and (+)-optical isomers ((+)-OMDV and (+)-OTDV) by HPLC. Read More

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http://dx.doi.org/10.1002/syn.22176DOI Listing

Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy.

Brain Pathol 2020 Jun 5. Epub 2020 Jun 5.

Neuropathology Brain Bank & Research CoRE, Department of Pathology, Nash Family Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy characterized by accumulation of hyperphosphorylated tau (p-tau) in perivascular aggregates in neurons and glia at the depths of neocortical sulci and progresses to diffuse neocortical, allocortical and brainstem structures. The strongest risk factor is exposure to repetitive head impacts acquired most commonly through contact sports and military service. Given that CTE can only be definitively diagnosed after death, a better understanding of the cellular and molecular changes in CTE brains may lead to identification of mechanisms that could be used for novel biomarkers, monitoring progression, or therapeutic development. Read More

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http://dx.doi.org/10.1111/bpa.12867DOI Listing

A novel conversion prediction method of MCI to AD based on longitudinal dynamic morphological features using ADNI structural MRIs.

J Neurol 2020 Jun 4. Epub 2020 Jun 4.

College of Information Science and Engineering, Lanzhou University, Lanzhou, China.

Mild cognitive impairment (MCI) is a pre-existing state of Alzheimer's disease (AD). An accurate prediction on the conversion from MCI to AD is of vital clinical significance for potential prevention and treatment of AD. Longitudinal studies received widespread attention for investigating the disease progression, though most studies did not sufficiently utilize the evolution information. Read More

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http://dx.doi.org/10.1007/s00415-020-09890-5DOI Listing

Peptidyl-Prolyl Isomerase Pin1 and Alzheimer's Disease.

Front Cell Dev Biol 2020 15;8:355. Epub 2020 May 15.

Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of senile plaques composed of beta-amyloid peptides derived from amyloid precursor protein (APP). The peptidyl-prolyl isomerase Pin1 binds to phosphorylated serine or threonine residues preceding proline and regulates the biological functions of its substrates. Read More

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http://dx.doi.org/10.3389/fcell.2020.00355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243138PMC

Association Between Cerebrospinal Fluid Biomarkers and Age-related Brain Changes in Patients with Normal Pressure Hydrocephalus.

Sci Rep 2020 Jun 4;10(1):9106. Epub 2020 Jun 4.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard avenue, Toronto, ON, M5T 2S8, Canada.

Our study aimed to: 1)investigate the diagnostic utility of CSF Aβ42, t-tau, and p-tau to differentiate normal-pressure-hydrocephalus(NPH) from Alzheimer's-disease(AD) and normal-controls; and 2)investigate if age and ventricular size affect the levels of CSF biomarkers in NPH patients. We recruited 131 participants: (a)Suspected-NPH: 72 with ventriculomegaly and clinical symptoms of NPH. These participants were then divided into two groups of 1)Probable-NPH (N = 38) and 2)Unlikely-NPH (N = 34) based on whether participants experienced gait improvement after removal of a large amount of CSF; (b)AD group: 30 participants with CSF biomarkers and cognitive symptoms consistent with AD; (c)Control-group: 29 participants who were cognitively and functionally normal. Read More

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http://dx.doi.org/10.1038/s41598-020-66154-yDOI Listing

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.

Nat Commun 2020 Jun 4;11(1):2820. Epub 2020 Jun 4.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge, UK.

As an intrinsically disordered protein, monomeric alpha-synuclein (aSyn) occupies a large conformational space. Certain conformations lead to aggregation prone and non-aggregation prone intermediates, but identifying these within the dynamic ensemble of monomeric conformations is difficult. Herein, we used the biologically relevant calcium ion to investigate the conformation of monomeric aSyn in relation to its aggregation propensity. Read More

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http://dx.doi.org/10.1038/s41467-020-16564-3DOI Listing

Enduring changes in neuronal function upon systemic inflammation are NLRP3 inflammasome dependent.

J Neurosci 2020 Jun 4. Epub 2020 Jun 4.

Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, Germany

Neuroinflammation can be caused by various insults to the brain and represents an important pathological hallmark of neurodegenerative diseases including Alzheimer's disease. Infection-triggered acute systemic inflammation is able to induce neuroinflammation and may negatively affect neuronal morphology, synaptic plasticity and cognitive function. In contrast to acute effects, persisting consequences for the brain upon systemic immune stimulation remain largely unexplored. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0200-20.2020DOI Listing

Application of Deep Learning to Predict Standardized Uptake Value Ratio and Amyloid Status on F-Florbetapir PET Using ADNI Data.

AJNR Am J Neuroradiol 2020 Jun 4. Epub 2020 Jun 4.

From the Departments of Radiology (F.R., M.E.K., G.D., G.Z.)

Background And Purpose: Cortical amyloid quantification on PET by using the standardized uptake value ratio is valuable for research studies and clinical trials in Alzheimer disease. However, it is resource intensive, requiring co-registered MR imaging data and specialized segmentation software. We investigated the use of deep learning to automatically quantify standardized uptake value ratio and used this for classification. Read More

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http://dx.doi.org/10.3174/ajnr.A6573DOI Listing

Prospective associations between physical activity levels and white matter integrity in older adults: results from the MAPT study.

Maturitas 2020 Jul 23;137:24-29. Epub 2020 Apr 23.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 allée Jules Guesde, 31000 Toulouse, France; UPS/INSERM UMR 1027, University of Toulouse III, Toulouse, France Faculté de médecine 37 allées Jules Guesde 31000 Toulouse, France.

Background: Higher levels of physical activity (PA) are known to be associated with better white matter integrity measured by diffusion tensor imaging (DTI) in older adults in cross-sectional studies. However, no studies have investigated the association between PA levels and the evolution of DTI parameters (fractional anisotropy and mean diffusivity).

Objectives: To examine the cross-sectional associations between PA levels and DTI parameters, then to investigate the association between baseline PA levels and the evolution of DTI parameters in older adults. Read More

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http://dx.doi.org/10.1016/j.maturitas.2020.04.012DOI Listing

CaSR Antagonist (Calcilytic) NPS 2143 Hinders the Release of Neuroinflammatory IL-6, Soluble ICAM-1, RANTES, and MCP-2 from Aβ-Exposed Human Cortical Astrocytes.

Cells 2020 Jun 2;9(6). Epub 2020 Jun 2.

Human Histology and Embryology Section, Department of Surgery, Dentistry, Pediatrics and Gynecology, Medical School, University of Verona, Veneto, 37134 Verona, Italy.

Available evidence shows that human cortical neurons' and astrocytes' calcium-sensing receptors (CaSRs) bind Amyloid-beta (Aβ) oligomers triggering the overproduction/oversecretion of several Alzheimer's disease (AD) neurotoxinseffects calcilytics suppress. We asked whether AβCaSR signaling might also play a direct pro-neuroinflammatory role in AD. Cortical nontumorigenic adult human astrocytes (NAHAs) in vitro were untreated (controls) or treated with Aβ±NPS 2143 (a calcilytic) and any proinflammatory agent in their protein lysates and growth media assayed via antibody arrays, enzyme-linked immunosorbent assays (ELISAs), and immunoblots. Read More

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http://dx.doi.org/10.3390/cells9061386DOI Listing

Functional compensation and mechanism of choline acetyltransferase in the treatment of cognitive deficits in aged dementia mice.

Neuroscience 2020 Jun 1. Epub 2020 Jun 1.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 27th Taiping Road, Beijing 100850, China. Electronic address:

Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine (Ach). Exogenous supplementation with ChAT can functionally compensate for decreased Ach levels and ameliorate memory and cognitive deficits. In this paper, the treatment efficacy of recombinant ChAT (peptide transduction domain (PTD)-ChAT) and donepezil were compared in aged dementia mice, and their mechanisms were explored by performing the gene function annotation and enrichment analysis of differentially expressed genes. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.05.016DOI Listing

Aggressive behaviour of persons with dementia towards professional caregivers in the home care setting - a scoping review.

J Clin Nurs 2020 Jun 4. Epub 2020 Jun 4.

Center for Dementia Care, Institute of Applied Nursing Sciences, Department of Health, University of Applied Sciences FHS St. Gallen, Gallen, Switzerland.

Aims And Objectives: The aim of this scoping review was to outline and to examine the current research and grey literature on aggressive incidents of persons with dementia towards professional caregivers in the home care setting. We intended to identify evidence and research gaps in this field.

Background: Worldwide, around fifty million people are living with dementia. Read More

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http://dx.doi.org/10.1111/jocn.15363DOI Listing

N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer's disease.

Neuropathol Appl Neurobiol 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August-University, Von-Siebold-Str. 5, 37075, Göttingen, Germany.

Aims: The deposition of amyloid-β (Aβ) peptides in the form of extracellular plaques in the brain represents one of the classical hallmarks of Alzheimer's disease (AD). In addition to "full length" Aβ starting with aspartic acid (Asp-1), considerable amounts of various shorter, N-terminally truncated Aβ peptides have been identified by mass spectrometry in autopsy samples from individuals with AD.

Methods: Selectivity of several antibodies detecting full-length, total or N-terminally truncated Aβ species has been characterized with capillary isoelectric focusing assays using a set of synthetic Aβ peptides comprising different N-termini. Read More

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http://dx.doi.org/10.1111/nan.12637DOI Listing

Yishen Huazhuo Decoction induces autophagy to promote the clearance of Aβ1-42 in SAMP8 mice: mechanism research of a traditional Chinese formula against Alzheimer's disease.

CNS Neurol Disord Drug Targets 2020 Jun 4. Epub 2020 Jun 4.

Shenzhen Traditional Chinese Medicine Treatment Hospital, Shenzhen, 518100. China.

Background: Studies have found that autophagy could promote the clearance of Aβ. To promote and maintain the occurrence of autophagy in Alzheimer's disease (AD) might be a potential way to reduce neuronal loss and improve the learning and memory of AD.

Objective: To investigate the possible mechanisms of Yishen Huazhuo Decoction (YHD) against AD model. Read More

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http://dx.doi.org/10.2174/1871527319666200604174223DOI Listing

Amyloid beta (1-42) downregulates adenosine-2b receptors in addition to mitochondrial impairment and cholinergic dysfunction in memory-sensitive mouse brain regions.

J Recept Signal Transduct Res 2020 Jun 4:1-10. Epub 2020 Jun 4.

Division of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, India.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment. Adenosinergic receptors are considered as a potential alternative in the management of several neurodegenerative disorders. However, there is no information available on the role of A2b receptor in the pathophysiology of AD. Read More

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http://dx.doi.org/10.1080/10799893.2020.1767136DOI Listing

Assessing an evidence-based intervention for spouse caregivers of persons with Alzheimer's disease: results of a community implementation of the NYUCI in Israel.

Aging Ment Health 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Psychiatry, NYU School of Medicine, NYU Langone Health, New York, NY, USA.

Alzheimer's disease (AD) affects not only the person with the illness, but family caregivers as well. The NYU Caregiver Intervention (NYUCI), a psychosocial intervention which has demonstrated both short and long-term benefits for caregivers, has been used widely in the United States and in Australia and England. The Israeli study was a hybrid between a community implementation study and a randomized controlled trial (RCT) of the NYUCI in a non-English speaking country. Read More

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http://dx.doi.org/10.1080/13607863.2020.1774740DOI Listing

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

Stem Cells Transl Med 2020 Jun 4. Epub 2020 Jun 4.

School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression. In this scenario, mesenchymal stem cells (MSCs) have risen considerable interest thanks to their immunomodulatory properties, which have been largely ascribed to the release of extracellular vesicles (EVs), namely exosomes and microvesicles. Indeed, the beneficial effects of MSC-EVs in regulating the inflammatory response have been reported in different AD mouse models, upon chronic intravenous or intracerebroventricular administration. Read More

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http://dx.doi.org/10.1002/sctm.19-0327DOI Listing

Exploration of multi-target effects of 3-benzoyl-5-hydroxychromen-2-one in Alzheimer's disease cell and mouse models.

Aging Cell 2020 Jun 4. Epub 2020 Jun 4.

Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Microtubule-associated protein Tau, abundant in the central nervous system (CNS), plays crucial roles in microtubule assembly and stabilization. Abnormal Tau phosphorylation and aggregation are a common pathogenic hallmark in Alzheimer's disease (AD). Hyperphosphorylation of Tau could change its conformation and result in self-aggregation, increased oxidative stress, and neuronal death. Read More

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http://dx.doi.org/10.1111/acel.13169DOI Listing

Ethnobotany, ethnopharmacology, phytochemistry, biological activities and toxicity of Pistacia chinensis subsp. integerrima: A comprehensive review.

Phytother Res 2020 Jun 4. Epub 2020 Jun 4.

Department of Pharmacy, Shaheed Benazir Bhutto University, Sheringal Dir (U), Pakistan.

Pistacia chinensis subsp. integerrima (J. L. Read More

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http://dx.doi.org/10.1002/ptr.6720DOI Listing

[Virtual screen of effective AChE inhibitory constituents from Glycyrrhizae Radix et Rhizoma based on pharmacophore and molecular docking].

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2431-2438

Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University Xi'an 710062, China.

This research is to predict anti-Alzheimer's disease active constituents on the target of acetylcholinesterase(AChE) from Glycyrrhizae Radix et Rhizoma with the help of pharmacophore and molecular docking. AChE ligand-based pharmacophore model was set up and the molecular library of the constituents from Glycyrrhizae Radix et Rhizoma were established by collecting literature. Then the constituents from Glycyrrhizae Radix et Rhizoma were screen for the potential AChE inhibitory potency in silico through matching with the best pharmacophore model. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191112.201DOI Listing

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.

Proc Natl Acad Sci U S A 2020 Jun 3. Epub 2020 Jun 3.

Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom;

Protein misfolding and aggregation is the hallmark of numerous human disorders, including Alzheimer's disease. This process involves the formation of transient and heterogeneous soluble oligomers, some of which are highly cytotoxic. A major challenge for the development of effective diagnostic and therapeutic tools is thus the detection and quantification of these elusive oligomers. Read More

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http://dx.doi.org/10.1073/pnas.1919464117DOI Listing

Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease.

Acta Neuropathol Commun 2020 Jun 3;8(1):76. Epub 2020 Jun 3.

Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, AZ, USA.

Multiple system atrophy (MSA) is a rare adult-onset neurodegenerative disease of unknown cause, with no effective therapeutic options, and no cure. Limited work to date has attempted to characterize the transcriptional changes associated with the disease, which presents as either predominating parkinsonian (MSA-P) or cerebellar (MSC-C) symptoms. We report here the results of RNA expression profiling of cerebellar white matter (CWM) tissue from two independent cohorts of MSA patients (n = 66) and healthy controls (HC; n = 66). Read More

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http://dx.doi.org/10.1186/s40478-020-00950-5DOI Listing

Exploring pathways to Hospital Care for Patients with Alzheimer's disease and related dementias in rural South Western Uganda.

BMC Health Serv Res 2020 Jun 3;20(1):498. Epub 2020 Jun 3.

Mwanza Intervention Trials Unit, Mwanza, Tanzania.

Background: In order to analyze use of health services and identify sources of delays in accessing the right care for patients with Alzheimer's disease and related dementias (AD/ADRD), understanding of care seeking pathways is needed. The objectives of this study were: (i) to explore pathways to hospital care for patients with AD/ADRD and (ii) to describe challenges experienced by the patients and their families while seeking health care.

Methods: Using purposive sampling, 30-in-depth, semi-structured interviews were conducted among caregivers of older adults diagnosed with dementia from rural Southwestern, Uganda. Read More

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http://dx.doi.org/10.1186/s12913-020-05365-5DOI Listing

Exploring the Potential of Neuroproteomics in Alzheimer's Disease.

Curr Top Med Chem 2020 Jun 3. Epub 2020 Jun 3.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah. Saudi Arabia.

Alzheimer's disease (AD) is a progressive brain amyloidosis that damages brain regions associated with memory, thinking, behavioral and social skills. Neuropathologically AD is characterized by intraneuronal hyperphosphorylated tau inclusions as neurofibrillary tangles (NFTs), and buildup of extracellular amyloid beta (Aβ) peptide as senile plaques. Several biomarker tests capturing these pathologies have been developed. Read More

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http://dx.doi.org/10.2174/1568026620666200603112030DOI Listing
June 2020
3.402 Impact Factor

S100A6 and Its Brain Ligands in Neurodegenerative Disorders.

Int J Mol Sci 2020 Jun 1;21(11). Epub 2020 Jun 1.

Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.

The S100A6 protein is present in different mammalian cells and tissues including the brain. It binds Ca and Zn and interacts with many target proteins/ligands. The best characterized ligands of S100A6, expressed at high level in the brain, include CacyBP/SIP and Sgt1. Read More

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http://dx.doi.org/10.3390/ijms21113979DOI Listing

Diagnostic Biomarkers for Alzheimer's Disease Using Non-Invasive Specimens.

J Clin Med 2020 Jun 1;9(6). Epub 2020 Jun 1.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, UK.

Studies in the field of Alzheimer's disease (AD) have shown the emergence of biomarkers in biologic fluids that hold great promise for the diagnosis of the disease. A diagnosis of AD at a presymptomatic or early stage may be the key for a successful treatment, with clinical trials currently investigating this. It is anticipated that preventative and therapeutic strategies may be stage-dependent, which means that they have a better chance of success at a very early stage-before critical neurons are lost. Read More

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http://dx.doi.org/10.3390/jcm9061673DOI Listing

Chemical Characterization and Bioactive Properties of Different Extracts from , an Unexplored Plant Food.

Foods 2020 Jun 1;9(6). Epub 2020 Jun 1.

Department of Pharmaceutical Sciences, Food Science and Nutrition Section, University of Perugia, Via S. Costanzo 1, 06126 Perugia, Italy.

(L.) Medik. is a poorly studied plant species belonging to the Brassicaceae family, and usually used as cress in the salads. Read More

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http://dx.doi.org/10.3390/foods9060705DOI Listing

Transcranial Sonography Findings in Alzheimer's Disease: A New Imaging Biomarker.

Ultraschall Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

Objective:  To validate transcranial sonography (TCS) as a novel imaging tool for the assessment of medial temporal lobe (MTL) atrophy (MTA).

Materials And Methods:  Participants with Alzheimer's disease (AD, n = 30) and age-sex-matched controls (n = 30) underwent TCS and MRI. On TCS, MTL structures (choroidal fissure (CF) and temporal horn (TH)) were measured and combined to create an MTA score in sonography (MTA-S). Read More

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http://dx.doi.org/10.1055/a-1146-3036DOI Listing

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing.

Cell Rep 2020 Jun;31(9):107719

Department of Pathology, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address:

SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer's disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dysfunction. SORL1-deficient hiPSC neurons show early endosome enlargement, a hallmark cytopathology of AD. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107719DOI Listing

Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.

Acta Trop 2020 May 31:105560. Epub 2020 May 31.

Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Medical University, Hefei, China. Electronic address:

Toxoplasma gondii (T. gondii) is a neurophilic and intracellular parasite that can affect plenty of vertebrate animals, including humans. Recent researches indicate that T. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105560DOI Listing

Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCs.

J Mol Cell Biol 2020 Jun 3. Epub 2020 Jun 3.

State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.

The induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to model and study Alzheimer's disease (AD) under patient-specific genetic background. The lower expression of transient receptor potential canonical 6 (TRPC6) was associated with AD patients, which might be involved in AD pathogenesis. However, the role of TRPC6 that played in AD process still needs more investigation in patient-relevant neurons. Read More

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http://dx.doi.org/10.1093/jmcb/mjaa027DOI Listing

Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial.

JAMA Psychiatry 2020 Jun 3. Epub 2020 Jun 3.

School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Importance: Depression is associated with increased inflammation, which may precede its onset, especially in older people. Some preclinical data suggest potential antidepressant effects of aspirin, supported by limited observational data suggesting lower rates of depression in individuals treated with aspirin. There currently appears to be no evidence-based pharmacotherapies for the primary prevention of depression. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1214DOI Listing

The impact of atlas-based MR attenuation correction on the diagnosis of FDG-PET/MR for Alzheimer's diseases- A simulation study combining multi-center data and ADNI-data.

PLoS One 2020 3;15(6):e0233886. Epub 2020 Jun 3.

Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland.

Background: The purpose of this study was to assess the impact of vendor-provided atlas-based MRAC on FDG PET/MR for the evaluation of Alzheimer's disease (AD) by using simulated images.

Methods: We recruited 47 patients, from two institutions, who underwent PET/CT and PET/MR (GE SIGNA) examination for oncological staging. From the PET raw data acquired on PET/MR, two FDG-PET series were generated, using vendor-provided MRAC (atlas-based) and CTAC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233886PLOS

A Comprehensive Evaluation of the Copying Process of a Complex Figure in Early- and Late-Onset Alzheimer's Disease: Quantitative Analysis of Digital Pen Data.

J Med Internet Res 2020 May 13. Epub 2020 May 13.

Center for Neuroscience, Korea Institute of Science and Technology, Seoul, KR.

Background: The Rey-Osterrieth Complex Figure Test (RCFT) is a neuropsychological test that is widely used to assess visual memory and visuoconstructional deficits in patients with cognitive impairment including Alzheimer's disease (AD). AD patients have an increased tendency for extraordinary behaviors in the RCFT for selecting the drawing area, organizing the figure, and deciding the order of images, among other activities. However, the conventional scoring system based on pen and paper has limited ability to reflect these detailed behaviors. Read More

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http://dx.doi.org/10.2196/18136DOI Listing

Functional coupling of presequence processing and degradation in human mitochondria.

FEBS J 2020 Jun 3. Epub 2020 Jun 3.

Faculty of Medicine, Institute of Biochemistry and Molecular Biology, ZBMZ, University of Freiburg, Germany.

The mitochondrial proteome is built and maintained mainly by import of nuclear-encoded precursor proteins. Most of these precursors use N-terminal presequences as targeting signals that are removed by mitochondrial matrix proteases. The essential mitochondrial processing protease MPP cleaves presequences after import into the organelle thereby enabling protein folding and functionality. Read More

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http://dx.doi.org/10.1111/febs.15358DOI Listing

Amyloid-beta induced glutamatergic receptor and transporter expression changes in the mouse hippocampus.

J Neurochem 2020 Jun 3. Epub 2020 Jun 3.

Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Alzheimer's Disease (AD) is the leading type of dementia worldwide. With an increasing burden of an aging population coupled with the lack of any foreseeable cure, AD warrants the current intense research effort on the toxic effects of an increased concentration of beta-amyloid (Aβ ) in the brain. Glutamate is the main excitatory brain neurotransmitter and it plays an essential role in the function and health of neurons and neuronal excitability. Read More

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http://dx.doi.org/10.1111/jnc.15099DOI Listing

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition.

Ann N Y Acad Sci 2020 Jun 3. Epub 2020 Jun 3.

Neuromodulation Laboratory, Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, the University of Hong Kong, Hong Kong, P. R. China.

Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although much effort has been made to decipher the pathogenesis of this disease, the mechanisms causing these detrimental outcomes remain obscure. Over the past few decades, neuroepigenetics has emerged as an important field that, among other things, explores how reversible modifications can change gene expression to control behavior and cognitive abilities. Read More

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http://dx.doi.org/10.1111/nyas.14373DOI Listing

Elevated amyloidoses of human IAPP and amyloid beta by lipopolysaccharide and their mitigation by carbon quantum dots.

Nanoscale 2020 Jun 3. Epub 2020 Jun 3.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. and Zhongshan Hospital, Fudan University, 111 Yixueyuan Rd, Xuhui District, Shanghai, 200032, China.

Type 2 diabetes (T2D) and Alzheimer's disease (AD) represent two most prevalent amyloid diseases with a significant global burden. Pathologically, T2D and AD are characterized by the presence of amyloid plaques consisting primarily of toxic human islet amyloid polypeptide (IAPP) and amyloid beta (Aβ). It has been recently revealed that the gut microbiome plays key functions in the pathological progression of neurological disorders through the production of bacterial endotoxins, such as lipopolysaccharide (LPS). Read More

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http://dx.doi.org/10.1039/d0nr02710cDOI Listing

Resting-state fMRI analysis in apathetic Alzheimer's disease.

Diagn Interv Radiol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, Behavioral Neurology and Movement Disorders Unit, İstanbul University İstanbul School of Medicine, İstanbul, Turkey;Hulusi Behcet Life Sciences Laboratory, Istanbul University, İstanbul, Turkey.

Purpose: Diagnosis of comorbid psychiatric conditions are a significant determinant for the prognosis of neurodegenerative diseases. Apathy, which is a behavioral executive dysfunction, frequently accompanies Alzheimer's disease (AD) and leads to higher daily functional loss. We assume that frontal lobe hypofunction in apathetic AD patients are more apparent than the AD patients without apathy. Read More

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http://dx.doi.org/10.5152/dir.2019.19445DOI Listing

[The functional activity of neutrophils in paranoid schizophrenia and Alzheimer's disease].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(4):97-101

Gilyarovsky Psychiatric Hospita - the branch of Moscow Psychiatric Clinical Hospital No.4, Moscow, Russia.

Objective: To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer's disease.

Material And Methods: The study included 40 patients with paranoid schizophrenia and 22 with Alzheimer's disease. To assess the functional activity of neutrophils, whole blood samples were analyzed using the chemiluminescent method with two-step cell stimulation. Read More

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http://dx.doi.org/10.17116/jnevro202012004197DOI Listing
January 2020

A human induced pluripotent stem cell-derived cortical neuron human-on-a chip system to study Aβ and tau-induced pathophysiological effects on long-term potentiation.

Alzheimers Dement (N Y) 2020 27;6(1):e12029. Epub 2020 May 27.

NanoScience Technology Center University of Central Florida Orlando Florida USA.

Introduction: The quest to identify an effective therapeutic strategy for neurodegenerative diseases, such as mild congitive impairment (MCI) and Alzheimer's disease (AD), suffers from the lack of good human-based models. Animals represent the most common models used in basic research and drug discovery studies. However, safe and effective compounds identified in animal studies often translate poorly to humans, yielding unsuccessful clinical trials. Read More

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http://dx.doi.org/10.1002/trc2.12029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253154PMC

Proteomic profiles of incident mild cognitive impairment and Alzheimer's disease among adults with Down syndrome.

Alzheimers Dement (Amst) 2020 21;12(1):e12033. Epub 2020 May 21.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA.

Introduction: We sought to determine if proteomic profiles could predict risk for incident mild cognitive impairment (MCI) and Alzheimer's disease (AD) among adults with Down syndrome (DS).

Methods: In a cohort of 398 adults with DS, a total of n = 186 participants were determined to be non-demented and without MCI or AD at baseline and throughout follow-up; n = 103 had incident MCI and n = 81 had incident AD. Proteomics were conducted on banked plasma samples from a previously generated algorithm. Read More

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http://dx.doi.org/10.1002/dad2.12033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241058PMC

Prognostic value of ATN Alzheimer biomarkers: 60-month follow-up results from the Argentine Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement (Amst) 2020 22;12(1):e12026. Epub 2020 May 22.

Department of Molecular Biology and Neuropathology Instituto de Investigaciones Neurológicas FLENI Buenos Aires Argentina.

Purpose: To describe results of the Amyloid, Tau, Neurodegeneration (ATN) research framework classification in the Argentine-Alzheimer's Disease Neuroimaging Initiative (arg-ADNI) cohort.

Methods: Twenty-three patients with mild cognitive impairment (MCI), 12 dementia of Alzheimer's type (DAT), and 14 normal controls were studied following the ADNI2 protocol. Patients were categorized according to presence or absence of the biomarkers for amyloid beta (Aβ; A: amyloid positron emission tomography [PET] scan or cerebrospinal fluid [CSF] Aβ42), tau (T: CSF phosphorylated-tau), and neurodegeneration (N: CSF total-tau, fluorodeoxyglucose [FDG]-PET scan, or structural magnetic resonance imaging [MRI] scan). Read More

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http://dx.doi.org/10.1002/dad2.12026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243942PMC