Neuroimage Clin 2021 Jun 14;31:102726. Epub 2021 Jun 14.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA; Indiana University Network Science Institute, Bloomington, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine (IUSM), Indianapolis, IN, USA; Indiana Alzheimer's Disease Research Center, IUSM, Indianapolis, IN, USA.
Understanding the interrelationships of clinical manifestations of Alzheimer's disease (AD) and functional connectivity (FC) as the disease progresses is necessary for use of FC as a potential neuroimaging biomarker. Degradation of resting-state networks in AD has been observed when FC is estimated over the entire scan, however, the temporal dynamics of these networks are less studied. We implemented a novel approach to investigate the modular structure of static (sFC) and time-varying (tvFC) connectivity along the AD spectrum in a two-sample Discovery/Validation design (n = 80 and 81, respectively). Read More