Neurol Genet 2020 Aug 7;6(4):e462. Epub 2020 Jul 7.
Department of Neurology (C.Z., K.S., Y.P.M.), Vagelos College of Physicians and Surgeons, Columbia University, New York, NY; Department of Neurology (C.Z.), Penn State Health Milton S. Hershey Medical Center; Department of Public Health Sciences (C.Z.), Pennsylvania State College of Medicine, Pennsylvania State University, Hershey, PA; Department of Biostatistics (Y.K.C.), Mailman School of Public Health, Columbia University, New York, NY; Departments of Neurology (R.L.S.), Public Health Sciences, and Human Genomics, Miller School of Medicine, University of Miami, Miami, FL; Cognitive Neuroscience Division (Y.S.), Department of Neurology, Vagelos College of Physicians and Surgeons, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, Columbia University, New York, NY; Department of Neurology (M.S.V.E.), Vagelos College of Physicians and Surgeons; and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY.
Objective: We investigated whether is an effect modifier of the association between infectious burden (IB) and poor cognition in a multiethnic cohort, the Northern Manhattan Study.
Methods: IB was assessed by a quantitative weighted index of exposure to common pathogens associated with vascular risk, infectious burden index (IBI), and by serology for individual infections. Cognition was assessed by completion of the Mini-Mental State Examination at baseline and a full neuropsychological test battery after a median follow-up of approximately 6 years. Read More