Search our Database of Scientific Publications and Authors

I’m looking for a

    1 results match your criteria Alzheimer's & Dementia[Journal]

    1 OF 1

    Phosphorylation of tau by cyclic-AMP-dependent protein kinase.
    Dementia 1993 Sep-Oct;4(5):256-63
    Department of Neuroscience, Institute of Psychiatry, London, UK.
    Alzheimer's disease paired helical filaments contain abnormally phosphorylated tau (PHF-tau) which has reduced electrophoretic mobility on sodium dodecyl sulphate polyacrylamide electrophoresis. We have investigated the effects of cyclic-AMP-dependent protein kinase (PKA) on recombinant human tau isoforms and two recombinant tau fragments. PKA phosphorylated tau and reduced its electrophoretic mobility, phosphorylation towards the C-terminus of tau having a major influence on this property. Read More

    1 OF 1