162,964 results match your criteria Alzheimer's & dementia : the journal of the Alzheimer's Association[Journal]


Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells.

J Cell Mol Med 2020 Jul 1. Epub 2020 Jul 1.

ALSaTECH, Tufts Biolabs Launchpad, Boston, Massachusetts, USA.

In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood-brain barrier (BBB) breakdown. After intravenous or intra-arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Read More

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http://dx.doi.org/10.1111/jcmm.15511DOI Listing

Analysis of Neuropsychiatric Symptoms in Patients with Alzheimer's Disease Using Quantitative EEG and sLORETA.

Neurodegener Dis 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Neurology, The Catholic University of Korea Bucheon St. Mary's Hospital, Bucheon, Republic of Korea.

Objective: The electrocortical activities associated with the neuropsychiatric symptoms (NPSs) of Alzheimer's disease (AD) were investigated using frequency-domain electroencephalography (EEG) spectral source analysis, and the potential electrocortical indices identified.

Materials And Methods: Scalp EEG data were obtained from 51 patients with AD to investigate the presence of four NPS subdomains, hyperactivity, psychosis, affective symptoms, and apathy. EEG power spectra and the standardized low-resolution brain electromagnetic tomography (sLORETA)-localized EEG cortical sources were compared between the groups with and without the four NPS subdomains in eight frequency bands: 1-4, 4-8, 8-10, 10-12, 12-18, 18-20, 20-30, and 30-45 Hz. Read More

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http://dx.doi.org/10.1159/000508130DOI Listing

The Power of EEG to Predict Conversion from Mild Cognitive Impairment and Subjective Cognitive Decline to Dementia.

Dement Geriatr Cogn Disord 2020 Jul 1:1-10. Epub 2020 Jul 1.

Department of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland.

Introduction: The aim of this study was to examine if quantitative electroencephalography (qEEG) using the statistical pattern recognition (SPR) method could predict conversion to dementia in patients with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).

Methods: From 5 Nordic memory clinics, we included 47 SCD patients, 99 MCI patients, and 67 healthy controls. EEGs analyzed with the SPR method together with clinical data recorded at baseline were evaluated. Read More

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http://dx.doi.org/10.1159/000508392DOI Listing

Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.

Cell Rep 2020 Jun;31(13):107843

Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA. Electronic address:

Damage-associated microglia (DAM) profiles observed in Alzheimer's disease (AD)-related mouse models reflect an activation state that could modulate AD risk or progression. To learn whether human AD microglia (HAM) display a similar profile, we develop a method for purifying cell types from frozen cerebrocortical tissues for RNA-seq analysis, allowing better transcriptome coverage than typical single-nucleus RNA-seq approaches. The HAM profile we observe bears little resemblance to the DAM profile. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107843DOI Listing

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

Cell Rep 2020 Jun;31(13):107839

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037, USA; Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117549, Singapore. Electronic address:

Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (APP) at position D664 by caspases that release the putatively cytotoxic C31 peptide. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107839DOI Listing

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders.

Mech Ageing Dev 2020 Jun 28:111297. Epub 2020 Jun 28.

Department of Neurology and Neurosurgery, McGill University, Montreal, QC, H4A 3J1, Canada; Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, QC, H4A 3J1, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, H4A 3J1, Canada; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

While aging is the greatest risk factor for the development of neurodegenerative disease, the role of aging in these diseases is poorly understood. In the inherited forms of these diseases, the disease-causing mutation is present from birth but symptoms appear decades later. This indicates that these mutations are well tolerated in younger individuals but not in older adults. Read More

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http://dx.doi.org/10.1016/j.mad.2020.111297DOI Listing

Demographic Effects on Longitudinal Semantic Processing, Working Memory, and Cognitive Speed.

J Gerontol B Psychol Sci Soc Sci 2020 Jul 1. Epub 2020 Jul 1.

The Graduate Center of the City University of New York, New York, NY.

Objectives: To better understand and compare effects of aging and education across domains of language and cognition, we investigated whether 1) these domains show different associations with age and education, 2) these domains show similar patterns of age-related change over time, and 3) education moderates the rate of decline in these domains.

Methods: We analyzed data from 306 older adults aged 55-85 at baseline of whom 116 returned for follow-up 4-8 years later. An exploratory factor analysis identified domains of language and cognition across a range of tasks. Read More

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http://dx.doi.org/10.1093/geronb/gbaa080DOI Listing

Patterns of Dyadic Appraisal of Decision-Making Involvement of African American Persons Living with Dementia.

Gerontologist 2020 Jul 1. Epub 2020 Jul 1.

Connell School of Nursing, Boston College, Chestnut Hill, MA.

Background And Objectives: Greater everyday decision-making involvement by persons living with dementia (PLWD) and congruent appraisal between PLWDs and their caregivers have been associated with better quality of life (QOL) for both members of the dyad. However, no study has examined the association between the appraisals of everyday decision-making involvement of PLWDs and their QOL among African Americans.

Research Design And Methods: A secondary analysis of cross-sectional data from 62 African American dementia dyads was conducted. Read More

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http://dx.doi.org/10.1093/geront/gnaa086DOI Listing

"Grumpy" or "furious"? arousal of emotion labels influences judgments of facial expressions.

PLoS One 2020 1;15(7):e0235390. Epub 2020 Jul 1.

School of Psychology, The University of Queensland, St Lucia, Brisbane, QLD, Australia.

Whether language information influences recognition of emotion from facial expressions remains the subject of debate. The current studies investigate how variations in emotion labels that are paired with expressions influences participants' judgments of the emotion displayed. Static (Study 1) and dynamic (Study 2) facial expressions depicting eight emotion categories were paired with emotion labels that systematically varied in arousal (low and high). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235390PLOS

What older adults do with the results of dementia screening programs.

PLoS One 2020 1;15(7):e0235534. Epub 2020 Jul 1.

Department of Neurology, Comprehensive Center for Brain Health, University of Miami Miller School of Medicine, Miami, Florida, United States of America.

Introduction: Alzheimer's disease and related dementias (ADRD) and mild cognitive impairment (MCI) are often under-recognized in the community. MCI/ADRD screening could offer benefits such as early treatment, research participation, lifestyle modification, and advanced care planning. To date, there are no clear guidelines regarding the benefits vs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235534PLOS

Pineal volume reduction in patients with mild cognitive impairment who converted to Alzheimer's disease.

Psychiatry Clin Neurosci 2020 Jul 1. Epub 2020 Jul 1.

Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Aim: Pineal parenchymal volume (PPV) reduction is one of the predisposing factors for Alzheimer's disease (AD). Therefore, PPV could be used as a predictor of developing AD in clinical settings. We investigated whether PPV in patients with mild cognitive impairment (MCI) was correlated with conversion of these patients to AD. Read More

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http://dx.doi.org/10.1111/pcn.13103DOI Listing

Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

JAMA Psychiatry 2020 Jul 1. Epub 2020 Jul 1.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

Importance: Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatment and prevention of Alzheimer disease and related dementias.

Objective: To identify proteins associated with cognitive resilience via a proteome-wide association study of the human dorsolateral prefrontal cortex.

Design, Setting, And Participants: This study used data from 391 community-dwelling older persons who participated in the Religious Orders Study and the Rush Memory and Aging Project. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2020.1807DOI Listing

Two-dimensional identification and localization of isomers in crystallin peptides using TWIM-MS.

Analyst 2020 Jul 1. Epub 2020 Jul 1.

Department of Chemistry, University of California, Riverside, California 92521, USA.

Recent studies have illuminated connections between spontaneous chemical reactions that cause isomerization at specific protein residues and various age-related diseases including cataracts and Alzheimer's. These discoveries provide impetus for better analytical methods to detect and characterize isomerization in proteins, which will enable a more complete understanding of the underlying relationship between these modifications and biology. Herein we employ a two-dimensional approach for identification of peptides isomers that also includes pinpointing of the modified residue. Read More

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http://dx.doi.org/10.1039/d0an01036gDOI Listing

Effectiveness of "Reducing Disability in Alzheimer's Disease" Among Dyads With Moderate Dementia.

J Appl Gerontol 2020 Jul 1:733464820934683. Epub 2020 Jul 1.

University of Kansas Alzheimer's Disease Center, Fairway, USA.

Replications of evidence-based dementia care receiver-caregiver dyad interventions in the community are scarce. We aimed to assess the effectiveness of the Kansas City implementation of Reducing Disability in Alzheimer's Disease (RDAD) among a convenience sample of dyads with moderate dementia, which addressed needs identified by nine participating community agencies. We hypothesized that dyads' mental health and physical activity outcomes would improve from baseline to end-of-treatment. Read More

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http://dx.doi.org/10.1177/0733464820934683DOI Listing

Cycloastragenol inhibits Aβ-induced blood-brain barrier disruption and enhances soluble Aβ efflux .

J Asian Nat Prod Res 2020 Jul 1:1-14. Epub 2020 Jul 1.

Department of Neurology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

This study aimed to evaluate the effect Cycloastragenol (CAG), a triterpenoid saponin isolated from the Radix astragali, on Aβ-induced BBB damage. An immortalized endothelial cell line (bEnd.3) was employed to mimic a BBB. Read More

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http://dx.doi.org/10.1080/10286020.2020.1786372DOI Listing

A Systematic Review of Minor Phytocannabinoids with Promising Neuroprotective Potential.

Br J Pharmacol 2020 Jul 1. Epub 2020 Jul 1.

Division of Medical Sciences & Graduate Entry Medicine, School of Medicine, University of Nottingham, Royal Derby Hospital, DE22 3DT, United Kingdom.

Embase and Pubmed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, aside from cannabidiol and Δ -tetrahydrocannabinol, including Δ -tetrahydrocannabinolic acid (Δ -THCA), Δ -tetrahydrocannabivarin (Δ -THCV), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabichromevarin (CBCV), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabigerivarin (CBGV), cannabigerovarinic acid (CBGVA), cannabichromevarinic acid (CBCVA) cannabidivarinic acid (CBDVA) and cannabinol (CBN). Out of 2,341 studies, 31 articles met inclusion criteria. CBG (range 5 mg. Read More

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http://dx.doi.org/10.1111/bph.15185DOI Listing

Increased expression and retention of the secretory chaperone proSAAS following cell stress.

Cell Stress Chaperones 2020 Jul 1. Epub 2020 Jul 1.

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn St, HSF2, S267, Baltimore, MD, 21201, USA.

The secretory pathway of neurons and endocrine cells contains a variety of mechanisms designed to combat cellular stress. These include not only the unfolded protein response pathways but also diverse chaperone proteins that collectively work to ensure proteostatic control of secreted and membrane-bound molecules. One of the least studied of these chaperones is the neural- and endocrine-specific molecule known as proSAAS. Read More

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http://dx.doi.org/10.1007/s12192-020-01128-7DOI Listing

Connectome mapping with edge density imaging differentiates pediatric mild traumatic brain injury from typically developing controls: proof of concept.

Pediatr Radiol 2020 Jun 30. Epub 2020 Jun 30.

Neural Connectivity Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry St., Suite 350, San Francisco, CA, 94158, USA.

Background: Although acute neurologic impairment might be transient, other long-term effects can be observed with mild traumatic brain injury. However, when pediatric patients with mild traumatic brain injury present for medical care, conventional imaging with CT and MR imaging often does not reveal abnormalities.

Objective: To determine whether edge density imaging can separate pediatric mild traumatic brain injury from typically developing controls. Read More

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http://dx.doi.org/10.1007/s00247-020-04743-9DOI Listing

Mechanisms of γ-Secretase Activation and Substrate Processing.

ACS Cent Sci 2020 Jun 4;6(6):969-983. Epub 2020 Jun 4.

Center for Computational Biology and Department of Molecular Biosciences, and Department of Medicinal Chemistry, School of Pharmacy, University of Kansas, Lawrence, Kansas 66047, United States.

Amyloid β-peptide, the principal component of characteristic cerebral plaques of Alzheimer's disease (AD), is produced through intramembrane proteolysis of the amyloid precursor protein (APP) by γ-secretase. Despite the importance in the pathogenesis of AD, the mechanisms of intramembrane proteolysis and substrate processing by γ-secretase remain poorly understood. Here, complementary all-atom simulations using a robust Gaussian accelerated molecular dynamics (GaMD) method and biochemical experiments were combined to investigate substrate processing of wildtype and mutant APP by γ-secretase. Read More

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http://dx.doi.org/10.1021/acscentsci.0c00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318072PMC

Down syndrome: A curative prospect?

Authors:
Jean A Rondal

AIMS Neurosci 2020 22;7(2):168-193. Epub 2020 Jun 22.

University of Liège, Cognitive Sciences, Building 32, Sart Tilman, Liège 4000, Belgium.

Experimental work regarding corrective actions on chromosomes and genes, and control of gene products is yielding promising results. It opens the way to advances in dealing with the etiological aspects of Down syndrome and may lead to important changes in the life of individuals affected with this condition. A small number of molecules are being investigated in pharmacological research that may have positive effects on intellectual functioning. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321764PMC

Brain structure changes over time in normal and mildly impaired aged persons.

AIMS Neurosci 2020 20;7(2):120-135. Epub 2020 May 20.

Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky, USA.

Structural brain changes in aging are known to occur even in the absence of dementia, but the magnitudes and regions involved vary between studies. To further characterize these changes, we analyzed paired MRI images acquired with identical protocols and scanner over a median 5.8-year interval. Read More

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http://dx.doi.org/10.3934/Neuroscience.2020009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321765PMC

Unsupervised assessment of cognition in the Healthy Brain Project: Implications for web-based registries of individuals at risk for Alzheimer's disease.

Alzheimers Dement (N Y) 2020 26;6(1):e12043. Epub 2020 Jun 26.

Melbourne Dementia Research Centre Florey Institute of Neuroscience and Mental Health and the University of Melbourne Parkville Victoria Australia.

Introduction: Web-based platforms are used increasingly to assess cognitive function in unsupervised settings. The utility of cognitive data arising from unsupervised assessments remains unclear. We examined the acceptability, usability, and validity of unsupervised cognitive testing in middle-aged adults enrolled in the Healthy Brain Project. Read More

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http://dx.doi.org/10.1002/trc2.12043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317647PMC

mutations reduce T-synthase activity in advanced Alzheimer's disease.

Alzheimers Dement (N Y) 2020 26;6(1):e12040. Epub 2020 Jun 26.

Neurosurgery Research Laboratory Department of Neurosurgery Montefiore Medical Center and Albert Einstein College of Medicine Bronx New York USA.

Introduction: Mutations in brain tissues that cumulate with age may contribute to Alzheimer's disease (AD). Abnormal glycoprotein and Tn antigen expression have been demonstrated in AD. We identified / mutations in AD and age-matched normals without AD. Read More

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http://dx.doi.org/10.1002/trc2.12040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317644PMC

Plasma proteomic signatures predict dementia and cognitive impairment.

Alzheimers Dement (N Y) 2020 9;6(1):e12018. Epub 2020 May 9.

Translational Gerontology Branch National Institute on Aging NIH Baltimore Maryland.

Introduction: Biomarker discovery of dementia and cognitive impairment is important to gather insight into mechanisms underlying the pathogenesis of these conditions.

Methods: In 997 adults from the InCHIANTI study, we assessed the association of 1301 plasma proteins with dementia and cognitive impairment. Validation was conducted in two Alzheimer's disease (AD) case-control studies as well as endophenotypes of AD including cognitive decline, brain amyloid burden, and brain volume. Read More

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http://dx.doi.org/10.1002/trc2.12018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210784PMC

Total flavonoids of alleviates cognitive impairment in mice.

Biomed Rep 2020 Aug 9;13(2). Epub 2020 Jun 9.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Dalian, Liaoning 116024, P.R. China.

Cognitive impairment (CI) refers to dysfunctional cognition, which encompasses a spectrum of disorders, ranging from mild cognitive impairment to dementia. Any factor that results in cortical damage may cause CI. Total flavonoids of (TFSP), have shown promising antioxidant and protective effects in animal models. Read More

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http://dx.doi.org/10.3892/br.2020.1315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323453PMC

Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease.

Authors:
Pamela A Maher

Yale J Biol Med 2020 06 29;93(2):365-373. Epub 2020 Jun 29.

Salk Institute for Biological Studies, La Jolla, CA.

Alzheimer's disease (AD) is the most common form of dementia with the numbers expected to increase dramatically as our society ages. There are no treatments to cure, prevent, or slow down the progression of the disease. Age is the single greatest risk factor for AD. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309672PMC

Change in Functional Brain Activation Patterns Induced by Olfactory Stimulation in Multiple Sclerosis.

Neuropsychiatr Dis Treat 2020 9;16:1451-1458. Epub 2020 Jun 9.

Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, People's Republic of China.

Background: Olfactory disorder is one of the commonly appearing symptoms in diseases like Parkinson's disease (PD) and Alzheimer's disease (AD). However, reports of olfactory changes in multiple sclerosis (MS) are scarce and usually ignored or seldom recognized by clinicians. The majority of current research is based on subjective answers obtained by smelling odorants. Read More

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http://dx.doi.org/10.2147/NDT.S252933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294099PMC

Extent and Factors Associated with Adherence to Antidepressant Treatment During Acute and Continuation Phase Depression Treatment Among Older Adults with Dementia and Major Depressive Disorder.

Neuropsychiatr Dis Treat 2020 8;16:1433-1450. Epub 2020 Jun 8.

Banner Alzheimer's Institute, Phoenix, AZ, USA.

Purpose: Little is known about adherence to antidepressant treatment during acute and continuation phase of depression among older adults with dementia and newly diagnosed major depressive disorders (MDD). This study estimated the extent of and factors associated with adherence to acute and continuation phase antidepressant treatment among older adults with dementia and newly diagnosed MDD.

Methods: We conducted a retrospective cohort study using the Medicare 5% sample claims data (2012-2013) among older adults (age≥65 years) with dementia who were newly diagnosed with MDD. Read More

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http://dx.doi.org/10.2147/NDT.S241749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292261PMC

Methyl Jasmonate Protects Microglial Cells Against β-Amyloid-Induced Oxidative Stress and Inflammation via Nrf2-Dependent HO-1 Pathway.

Neuropsychiatr Dis Treat 2020 4;16:1399-1410. Epub 2020 Jun 4.

Department of Neurology, Weifang People's Hospital, Weifang 261031, Shandong, People's Republic of China.

Background: β-Amyloid (Aβ) induces oxidative stress and inflammation of microglial cells, thus leading to Alzheimer's disease. Methyl jasmonate (MeJA) is reported to have anti-inflammatory and anti-oxidant effects. However, the potential roles of MeJA in Aβ-induced cell activities and the underlying mechanism are unclear. Read More

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http://dx.doi.org/10.2147/NDT.S241142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283234PMC

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives.

Drug Des Devel Ther 2020 3;14:2165-2178. Epub 2020 Jun 3.

Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Introduction: The current study was designed to synthesize derivatives of succinimide and compare their biological potency in anticholinesterase, alpha-glucosidase inhibition, and antioxidant assays.

Methods: In this research, two succinimide derivatives including ()-1-(2,5-dioxo-1-phenylpyrrolidin-3-yl) cyclohexanecarbaldehyde (Compound ) and ()-2-(()-2,5-dioxo-1-phenylpyrrolidin-3-yl)-2-phenylpropanal (Compound ) were synthesized using Michael addition. Both the compounds, ie, and were evaluated for in-vitro acetylcholinesterase (AChE), butyrylctcholinesterase (BChE), antioxidant, and α-glucosidase inhibitory potentials. Read More

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http://dx.doi.org/10.2147/DDDT.S237420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285812PMC

Author Correction: Multimodal hippocampal subfield grading for Alzheimer's disease classification.

Sci Rep 2020 Jun 30;10(1):10969. Epub 2020 Jun 30.

Univ. Bordeaux, LaBRI, UMR 5800, PICTURA, 33400, Talence, France.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41598-020-67581-7DOI Listing

Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Sci Rep 2020 Jun 30;10(1):10636. Epub 2020 Jun 30.

Max Planck Institute for Human Development, Berlin, Germany.

It has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the cross-sectional data of 1,380 Berlin Aging Study II (BASE-II) participants aged 60 years and older (52. Read More

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http://dx.doi.org/10.1038/s41598-020-66783-3DOI Listing

Community memory screening as a strategy for recruiting older adults into Alzheimer's disease research.

Alzheimers Res Ther 2020 Jun 30;12(1):78. Epub 2020 Jun 30.

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0948, USA.

Background: Growing awareness of Alzheimer's disease (AD) has prompted a demand for quick and effective ways to screen for memory loss and cognitive decline in large numbers of individuals in the community. Periodic Memory Screening Day events provide free, brief cognitive screening aimed at those 65 years and older, and can serve as an opportunity to gauge participants' attitudes towards AD research and recruit them into ongoing research projects.

Methods: Over 6 single-day events in 2 years, more than 574 individuals were individually screened using the MoCA and a story recall task (immediate and delayed), given feedback about their performance, and introduced to AD research and opportunities to participate. Read More

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http://dx.doi.org/10.1186/s13195-020-00643-0DOI Listing

Insights into lncRNAs in Alzheimer's Disease Mechanisms.

RNA Biol 2020 Jun 30. Epub 2020 Jun 30.

Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China , Hefei 230001, China.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common dementia among the elderly. The pathophysiology of AD is characterized by two hallmarks: amyloid plaques, produced by amyloid β (Aβ) aggregation, and neurofibrillary tangle (NFT), produced by accumulation of phosphorylated tau. The regulatory roles of non-coding RNAs (ncRNAs), particularly long noncoding RNAs (lncRNAs), have been widely recognized in gene expression at the transcriptional and posttranscriptional levels. Read More

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http://dx.doi.org/10.1080/15476286.2020.1788848DOI Listing

A Reckoning to Keep Doing What We Are Already Doing With PET and SPECT Functional Neuroimaging.

Am J Psychiatry 2020 Jul;177(7):637-638

Synaptic Space, Denver, Neuro-Luminance Brain Health Centers, Denver, and Neuro-Laser Foundation, Denver (Henderson); Department of Nuclear Medicine, Lions Gate Hospital, University of British Columbia, Vancouver, Canada (Cohen); Rossiter-Thornton Associates, Toronto (Thornton); DrSpectScan.org, Lake Elsinore, Calif. (Uszler); Department of Nuclear Medicine, Southlake Regional Health Center, Newmarket, Ontario, Canada (Siow); Hollywood Private Hospital, Perth, Australia (Cardaci); Drs. van Lierop and McLean are in private practice in Toronto.

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http://dx.doi.org/10.1176/appi.ajp.2020.19080801DOI Listing

Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia.

Int J Mol Sci 2020 Jun 28;21(13). Epub 2020 Jun 28.

Department of Pathophysiology, Medical University of Lublin, 20-090 Lublin, Poland;

Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after brain ischemia, and their roles in the postischemic period. Recent advances in understanding the postischemic mechanisms in development of neurodegeneration have revealed dysregulation of amyloid protein precursor, α-, β- and γ-secretase and tau protein genes. Read More

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http://dx.doi.org/10.3390/ijms21134599DOI Listing

On-Chip Detection of the Biomarkers for Neurodegenerative Diseases: Technologies and Prospects.

Micromachines (Basel) 2020 Jun 28;11(7). Epub 2020 Jun 28.

Electrical and Computer Engineering Department, Iowa State University, Ames, IA 50011, USA.

Alzheimer's disease (AD), Parkinson's disease (PD) and glaucoma are all regarded as neurodegenerative diseases (neuro-DDs) because these diseases are highly related to the degeneration loss of functions and death of neurons with aging. The conventional diagnostic methods such as neuroimaging for these diseases are not only expensive but also time-consuming, resulting in significant financial burdens for patients and public health challenge for nations around the world. Hence early detection of neuro-DDs in a cost-effective and rapid manner is critically needed. Read More

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http://dx.doi.org/10.3390/mi11070629DOI Listing

A Combined Deep-Learning and Lattice Boltzmann Model for Segmentation of the Hippocampus in MRI.

Sensors (Basel) 2020 Jun 28;20(13). Epub 2020 Jun 28.

School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.

Segmentation of the hippocampus (HC) in magnetic resonance imaging (MRI) is an essential step for diagnosis and monitoring of several clinical situations such as Alzheimer's disease (AD), schizophrenia and epilepsy. Automatic segmentation of HC structures is challenging due to their small volume, complex shape, low contrast and discontinuous boundaries. The active contour model (ACM) with a statistical shape prior is robust. Read More

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http://dx.doi.org/10.3390/s20133628DOI Listing

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters.

Pharmaceutics 2020 Jun 28;12(7). Epub 2020 Jun 28.

UCIBIO/REQUIMTE, MEDTECH Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.

Rivastigmine is a drug commonly used in the management of Alzheimer's disease that shows bioavailability problems. To overcome this, the use of nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed a double optimization of a rivastigmine-loaded NLC formulation for direct drug delivery from the nose to the brain using the quality by design (QbD) approach, whereby the quality target product profile (QTPP) was the requisite for nose to brain delivery. Read More

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http://dx.doi.org/10.3390/pharmaceutics12070599DOI Listing

Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.

Authors:
Yves Jossin

Biomolecules 2020 Jun 26;10(6). Epub 2020 Jun 26.

Laboratory of Mammalian Development & Cell Biology, Institute of Neuroscience, Université Catholique de Louvain, 1200 Brussels, Belgium.

During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity. As a consequence, the Reelin signaling pathway has been associated with several human brain disorders such as lissencephaly, autism, schizophrenia, bipolar disorder, depression, mental retardation, Alzheimer's disease and epilepsy. Several elements of the signaling pathway are known. Read More

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http://dx.doi.org/10.3390/biom10060964DOI Listing

HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

Department of Medicine, School of Medicine, Jeju National University, 102 Jejudaehakno, Jeju 63243, Korea.

The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer's disease. Read More

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http://dx.doi.org/10.3390/ijms21124553DOI Listing

Predicting Clinical Dementia Rating Using Blood RNA Levels.

Genes (Basel) 2020 Jun 26;11(6). Epub 2020 Jun 26.

Department of Biology, Brigham Young University, Provo, UT 84602, USA.

The Clinical Dementia Rating (CDR) is commonly used to assess cognitive decline in Alzheimer's disease patients and is included in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. We divided 741 ADNI participants with blood microarray data into three groups based on their most recent CDR assessment: cognitive normal (CDR = 0), mild cognitive impairment (CDR = 0.5), and probable Alzheimer's disease (CDR ≥ 1. Read More

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http://dx.doi.org/10.3390/genes11060706DOI Listing

Machine Learning Models Reveal the Importance of Clinical Biomarkers for the Diagnosis of Alzheimer's Disease.

Stud Health Technol Inform 2020 Jun;272:478-481

College of Science and Engineering, Hamad Bin Khalifa University (HBKU), Doha, Qatar.

Alzheimer's Disease (AD) is a neurodegenerative disease that causes complications with thinking capability, memory and behavior. AD is a major public health problem among the elderly in developed and developing countries. With the growth of AD around the world, there is a need to further expand our understanding of the roles different clinical measurements can have in the diagnosis of AD. Read More

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http://dx.doi.org/10.3233/SHTI200599DOI Listing

eHealth Literacy Training Among Carers of Older People and People with Dementia: A Modified Delphi Survey.

Stud Health Technol Inform 2020 Jun;272:119-122

Cyprus University of Technology, Department of Nursing, Limassol, Cyprus.

New web-based services emerge to support carers in their role, but little is known regarding the way that carers use the internet or any related services. In an effort, to improve the health-related digital skills of carers aiming to support their caring role, we have developed eHealth Literacy Learning Skills among Carers of People with Dementia, the eLILY project. This paper presents the findings of a modified Delphi survey planned and delivered in the framework of the project as an effort to integrate stakeholders' knowledge and expertise in the proposed curriculum. Read More

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http://dx.doi.org/10.3233/SHTI200508DOI Listing

Sociodemographic Characteristics of Patients Registered with a Home Care Unit and an Evaluation of the Health Services Offered.

Sisli Etfal Hastan Tip Bul 2018 15;52(1):41-46. Epub 2018 Mar 15.

Department of Family Medicine, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Objectives: The growing aging population and the difficulties they often face in accessing health services brought attention to home care units. Home care units provide services that make it easier for the elderly to meet their healthcare needs. The aim of this study was to evaluate the sociodemographic characteristics of patients who were served by the home care unit of one hospital family medicine clinic and to assess the services provided. Read More

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http://dx.doi.org/10.14744/SEMB.2017.70883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315071PMC

Default Mode Network Connectivity in Alzheimers Disease.

Turk Psikiyatri Derg 2019 ;30(4):279-286

Objective: Alzheimer's Disease (AD) is a neurodegenerative condition characterized by functional and structural changes in the brain that are increasingly better visualized with the advances in new brain imaging techniques. Connectivity changes under the resting state condition especially in the internal connectivity network, named as the default mode network (DMN), are observed in AD. This paper aimed to investigate and discuss the findings on DMN connectivity. Read More

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January 2019

Gelatin grafted poly(D,L-lactide) as an inhibitor of protein aggregation: An in vitro case study.

Biopolymers 2020 Jun 30:e23383. Epub 2020 Jun 30.

Polymer Engineering Laboratory, School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India.

Amyloids are a group of proteins that are capable of forming aggregated amyloid fibrils, which is responsible for many neurodegenerative diseases including Alzheimer's disease (AD). In our previous study, synthesis and characterization of star-shaped poly(D,L-lactide)-b-gelatin (ss-pLG) have been reported. In the present work, we have extended our work to study ss-pLG against protein aggregation. Read More

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http://dx.doi.org/10.1002/bip.23383DOI Listing

Influence of plasma matrix metalloproteinase levels on longitudinal changes in Alzheimer's disease (AD) biomarkers and cognitive function in patients with mild cognitive impairment due to AD registered in the Alzheimer's Disease Neuroimaging Initiative database.

J Neurol Sci 2020 Jun 23;416:116989. Epub 2020 Jun 23.

Department of Psychiatry, Yokohama City University Graduate School of Medicine, Japan.

Objective: The present study investigated the effects of plasma matrix metalloproteinases (MMPs) on longitudinal changes in Alzheimer's disease (AD)-related biomarkers in cerebrospinal fluid (CSF), brain atrophy, and cognitive function in patients with mild cognitive impairment due to AD (MCI-AD).

Methods: We used data from the Alzheimer's Disease Neuroimaging Initiative database. We included 95 ApoE4-positive patients with MCI-AD who were confirmed to have low Aβ and/or high phosphorylated-tau (p-tau) in CSF. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116989DOI Listing

Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease.

Biomed Pharmacother 2020 Jun 27;129:110373. Epub 2020 Jun 27.

Chitkara College of Pharmacy, Chitkara University, Punjab, India. Electronic address:

A salient pathological features in Alzheimer's disease includes redox impairment and neuroinflammation. Nuclear factor erythroid 2-related factor 2 (Nrf2) and Nuclear factor kappa B (NF-ҡB) are the two key transcription factors that regulate cellular responses to redox impairment and neuroinflammation respectively. An effective way to confer neuroprotection in central nervous system (CNS) is the activation of a transcription factor i. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110373DOI Listing