106,826 results match your criteria Alveolar Proteinosis


Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients with ALK-positive NSCLC Following Treatment with Crizotinib.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Introduction: The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib in the real-world clinical setting.

Methods: Post-marketing surveillance was performed in Japan to obtain information on the safety and efficacy of crizotinib. Target patients included all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) who received crizotinib, during the enrollment period between May 2012 and December 2014. Read More

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December 2018
4 Reads

The effect of net gas volume changes on alveolar and arterial gas partial pressures in the presence of ventilation-perfusion mismatch.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Department of Anaesthesia, Austin Hospital, Australia.

The second gas effect (SGE) occurs when nitrous oxide enhances the uptake of volatile anesthetics administered simultaneously. Recent work shows that the SGE is greater in blood than in the gas phase, that this is due to ventilation-perfusion mismatch, that as mismatch increases, the SGE increases in blood but is diminished in the gas phase, and that these effects persist well into the period of nitrous oxide maintenance anesthesia. These modifications of the SGE are most pronounced with the low soluble agents in current use. Read More

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December 2018

Impaired Hypoxic Pulmonary Vasoconstriction in a Mouse Model of Leigh Syndrome.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesia, Massachusetts General Hospital, United States.

Hypoxic pulmonary vasoconstriction (HPV) is a physiological vasomotor response that maintains systemic oxygenation by matching perfusion to ventilation during alveolar hypoxia. Although mitochondria appear to play an essential role in HPV, the impact of mitochondrial dysfunction on HPV remains incompletely defined. Mice lacking the mitochondrial complex I (CI) subunit Ndufs4 (Ndufs4-/-) develop a fatal progressive encephalopathy and serve as a model for Leigh syndrome, the most common mitochondrial disease in children. Read More

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December 2018

Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages.

Virulence 2018 Dec 6. Epub 2018 Dec 6.

a Department of Medical Technology, Faculty of Allied Health Sciences , Thammasat University , Pathumthani 12120 Thailand.

Cryptococcus-macrophage interaction is crucial in the development of cryptococcocal diseases. C. neoformans and C. Read More

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December 2018

Magnetic resonance imaging of the time course of hyperpolarized Xe gas exchange in the human lungs and heart.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.

Purpose: To perform magnetic resonance imaging (MRI), human lung imaging, and quantification of the gas-transfer dynamics of hyperpolarized xenon-129 (HPX) from the alveoli into the blood plasma.

Materials And Methods: HPX MRI with iterative decomposition of water and fat with echo asymmetry and least-square estimation (IDEAL) approach were used with multi-interleaved spiral k-space sampling to obtain HPX gas and dissolved phase images. IDEAL time-series images were then obtained from ten subjects including six normal subjects and four patients with pulmonary emphysema to test the feasibility of the proposed technique for capturing xenon-129 gas-transfer dynamics (XGTD). Read More

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December 2018
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The mouse-canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models.

Biochem Biophys Rep 2019 Mar 24;17:23-26. Epub 2018 Nov 24.

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Podoplanin (PDPN) is a type I transmembrane heavily glycosylated sialoglycoprotein that is expressed in normal tissues such as pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is associated with hematogenous metastasis through interactions with the C-type lectin-like receptor 2 (CLEC-2). Previously, we have reported the development of a mouse monoclonal antibody (mAb), PMab-38 (IgG, kappa) against dog PDPN (dPDPN). Read More

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Efficacy of Alveolar Ridge Preservation after Maxillary Molar Extraction in Reducing Crestal Bone Resorption and Sinus Pneumatization: A Multicenter Prospective Case-Control Study.

Biomed Res Int 2018 4;2018:9352130. Epub 2018 Nov 4.

Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.

Aim: To evaluate, with three-dimensional analysis, the effectiveness of alveolar ridge preservation (ARP) after maxillary molar extraction in reducing alveolar bone resorption and maxillary sinus pneumatization when compared to unassisted socket healing.

Methods: Patients were included in the study following inclusion criteria and underwent minimally traumatic maxillary molar extraction followed by ARP using synthetic nanohydroxyapatite (Fisiograft Bone, Ghimas, Italy) (test group) or unassisted socket healing (control group). Cone-beam computerized tomographies (CBCT) were performed immediately after tooth extraction (T0) and 6 months postoperatively (T1). Read More

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November 2018

Preliminary Results of Bone Regeneration in Oromaxillomandibular Surgery Using Synthetic Granular Graft.

Biomed Res Int 2018 5;2018:8503427. Epub 2018 Nov 5.

Unit of Maxillo-Facial Surgery, University of Rome "Sapienza", Azienda Ospedaliera Universitaria "Sant'Andrea", Rome, Italy.

Traumatic, neoplastic, inflammatory, or infective dental removal promotes a gradual resorption process of bone which leads to a "nonuse" atrophy of the alveolar ridges. Many techniques allows restoring an appropriate bone thickness, but nowadays the attention is focused on the use of natural or synthetic grafts. Numerous studies have been conducted to develop and test new synthetic materials. Read More

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November 2018

Cyclic Stretch Enhances Osteogenic Differentiation of Human Periodontal Ligament Cells via YAP Activation.

Biomed Res Int 2018 5;2018:2174824. Epub 2018 Nov 5.

State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, China.

Periodontal remodeling and alveolar bone resorption and formation play essential roles during orthodontic tooth movement (OTM). In the process, human periodontal ligament cells (HPDLCs) sense and respond to orthodontic forces, contributing to the alveolar bone formation. However, the underlying mechanism in this process is not fully elucidated. Read More

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November 2018

Current Perspectives on Tooth Implantation, Attachment, and Replacement in Amniota.

Front Physiol 2018 21;9:1630. Epub 2018 Nov 21.

Team Evolution of Vertebrate Dentition, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Teeth and dentitions contain many morphological characters which give them a particularly important weight in comparative anatomy, systematics, physiology and ecology. As teeth are organs that contain the hardest mineralized tissues vertebrates can produce, their fossil remains are abundant and the study of their anatomy in fossil specimens is of major importance in evolutionary biology. Comparative anatomy has long favored studies of dental characters rather than features associated with tooth attachment and implantation. Read More

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November 2018
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Pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a dog.

Acta Vet Scand 2018 Dec 5;60(1):78. Epub 2018 Dec 5.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3508 TD, Utrecht, The Netherlands.

Background: Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary arterial hypertension (PAH) in humans and can be classified in idiopathic, heritable, drug and radiation-induced, and associated with connective tissue disease or human immunodeficiency virus infection. Recently, biallelic mutations of the EIF2AK4 gene have been discovered as a cause for an autosomal recessive form of PVOD in humans. In dogs, PAH is poorly characterized and is generally considered to be idiopathic or secondary to (for example) congenital left-to right cardiovascular shunts or heartworm disease. Read More

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December 2018

Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling.

Respir Res 2018 Dec 5;19(1):243. Epub 2018 Dec 5.

Emergency and Intensive Care Center, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan Province, PR, China.

Background: Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissue repair. In this study, we examined whether BML-111, a lipoxin A4 receptor agonist, could alter the phenotypes of AM and thus present prophylactic benefits for ALI.

Methods: In vitro, isolated AMs were treated with lipopolysaccharide (LPS) to induce ALI. Read More

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December 2018

Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species.

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Department of Chemistry, University of Nairobi, P. O. Box 30197, 00100 Nairobi, Kenya.

A phytochemical investigation of the roots of led to the isolation of -kaurane-type diterpenoids and additional phytochemicals (⁻). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the -kaurane-type diterpenoids (⁻, and ) were determined by single crystal X-ray diffraction studies. Read More

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December 2018

[The Pathogenesis of Pulmonary Emphysema - Laennec was right!]

Pneumologie 2018 Dec 3. Epub 2018 Dec 3.

Clinical Research, Thora Tech GmbH, Anwenderzentrum für Medizintechnik, Gießen.

Pulmonary emphysema is characterised by irreversible destruction and enlargement of alveolar structure distal to terminal bronchioles. Small conducting airways < 2 mm in diameter are the major site of chronic airway inflammation and obstruction in COPD patients. 80 - 90 % of the last generation of small conducting airways, the terminal bronchioles, are destroyed in patients with very severe COPD. Read More

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December 2018
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Osteoclasts in Bone Regeneration under Type 2 Diabetes Mellitus.

Acta Biomater 2018 Nov 30. Epub 2018 Nov 30.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA. Electronic address:

Diabetes mellitus (DM) affects hundreds of million people worldwide and the impaired bone healing is an important DM-related complication. Understanding how DM affects the activities of osteoclasts and the underlying mechanisms is crucial to the development of effective approaches for accelerating bone healing in DM condition. To date, however, the influence of DM on osteoclasts remains obscure and controversial. Read More

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November 2018
2 Reads

Interstitial lung disease associated with nanoparticle albumin-bound paclitaxel treatment in patients with lung cancer.

Jpn J Clin Oncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Nanoparticle albumin-bound paclitaxel is indicated for the treatment of patients with lung cancer. It can induce interstitial lung disease, but the incidence of nanoparticle albumin-bound paclitaxel-associated interstitial lung disease in clinical practice has not been determined. We investigated the incidence of interstitial lung disease in patients with lung cancer who had received nanoparticle albumin-bound paclitaxel therapy at our institution. Read More

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December 2018

Alveolar Ridge Expansion: Comparison of Osseodensification and Conventional Osteotome Techniques.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Hansjörg Wyss Department of Plastic Surgery, New York University Langone Medical Center, New York, NY.

Objective: The aim of this in vivo study is to compare the osseointegration of endosteal implants placed in atrophic mandibular alveolar ridges with alveolar ridge expansion surgical protocol via an experimental osseodensification drilling versus conventional osteotome technique.

Methods: Twelve endosteal implants, 4 mm × 13 mm, were placed in porcine models in horizontally atrophic mandibular ridges subsequent to prior extraction of premolars. Implants were placed with osseodensification drilling technique as the experimental group (n = 6) and osteotome site preparation as the control group (n = 6). Read More

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November 2018

New Technique for Closure of Alveolar Cleft With Umbilical Cord Stem Cells.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic and Reconstructive Surgery, Hospital de San José, Fundación Universitaria de Ciencias de la Salud, Servicio Cirugía Plástica Estética y Reconstructiva - Pabellón Arcadio Forero.

This article presents the case of a newly born female patient with a cleft of the primary palate (alveolar cleft), with an in utero diagnosis of the described cleft, from whom umbilical cord stem cells are obtained and cryopreserved. The patient is managed with nasoalveolar molding, and at 5 months of age, she is taken to surgery for cheiloplasty and gingivoperiostioplasty with umbilical cord stem cells. A radiographic and CT follow-up is carried out on the described cleft. Read More

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November 2018

A Novel Approach for the Reconstruction of Premaxilla by Archwise Distraction in Bilateral Cleft Lip and Palate.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthodontics, Faculty of Dentistry, Okan University, Istanbul, Turkey.

Interdental distraction osteogenesis has been introduced as a successful treatment protocol for repairing large clefts. In this article, a new method for reconstruction of the premaxilla in 2 bilateral cleft lip and palate patients is introduced. The aim was to distract the lateral segments through the curve of the dental arch, achieve complete closure of the gaps, and use the premaxilla as a bone graft. Read More

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November 2018

Maternal anaesthesia in open and fetoscopic surgery of foetal open spinal neural tube defects: A 6-year observational study.

Eur J Anaesthesiol 2018 Nov 30. Epub 2018 Nov 30.

From the Anaesthesiology and Intensive Care Department (SM, IG, MP, RP, DB, MdN), Maternal-Fetal Medicine Department (NM, SA, EC), Paediatric Surgery Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain (CG, JAM, ML).

Background: Prenatal myelomeningocele repair by open surgery can improve the neurological prognosis of children with this condition. A shift towards a fetoscopic approach seems to reduce maternal risks and improve obstetric outcomes.

Objective: The aim of this study was to report on the anaesthetic management of women undergoing prenatal open or fetoscopic surgery for neural tube defects. Read More

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November 2018

Lung development and emerging roles for type 2 immunity.

J Pathol 2018 Dec 2. Epub 2018 Dec 2.

Priority Research Centre's GrowUpWell and Healthy Lungs, School of Biomedical Sciences and Pharmacy, The University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW 2305, Australia.

Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into early adulthood. The process can be separated into five different developmental stages: embryonic, pseudoglandular, canalicular, saccular and alveolar. Read More

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December 2018

Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca/Calmodulin-Dependent Protein Kinase II.

Calcif Tissue Int 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China.

Hyperglycemia induces osteoclastogenesis and bone resorption through complicated, undefined mechanisms. Ca/calmodulin-dependent protein kinase II (CaMKII) promotes osteoclastogenesis, and could be activated by hyperglycemia. Here, we investigated whether CaMKII is involved in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption. Read More

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December 2018

Changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome patients with hepatopulmonary syndrome.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.

Objectives: To evaluate the changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome (BCS) patients with hepatopulmonary syndrome (HPS).

Methods: From June 2014 to June 2015, all patients with BCS who underwent balloon angioplasty or transjugular intrahepatic portosystemic shunt (TIPS) creation at our institution were eligible for inclusion in this study. Arterial blood gas analysis was performed with the patient in an upright position and breathing room air at 2-3 days and 1 and 3 months after the procedure. Read More

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November 2018
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Personalised organs-on-chips: functional testing for precision medicine.

Lab Chip 2018 Dec 3. Epub 2018 Dec 3.

Applied Stem Cell Technologies, University of Twente, Zuidhorst ZH127, PO Box 217, 7500 AE Enschede, The Netherlands.

Organs-on-chips are microfluidic systems with controlled, dynamic microenvironments in which cultured cells exhibit functions that emulate organ-level physiology. They can in principle be 'personalised' to reflect individual physiology, for example by including blood samples, primary human tissue, and cells derived from induced pluripotent stem cell-derived cells, as well as by tuning key physico-chemical parameters of the cell culture microenvironment based on personal health data. The personalised nature of such systems, combined with physiologically relevant read-outs, provides new opportunities for person-specific assessment of drug efficacy and safety, as well as personalised strategies for disease prevention and treatment; together, this is known as 'precision medicine'. Read More

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December 2018
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Vertical distraction osteogenesis of a reconstructed mandible with a free vascularized fibula flap: a report of two cases.

Maxillofac Plast Reconstr Surg 2018 Dec 15;40(1):32. Epub 2018 Nov 15.

1Division of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences, 2-5274, Gakkocho-Dori, Chuo-Ku, Niigata, 951-8514 Japan.

Background: The free vascularized fibula flap presents many advantages such as sufficient length of the bony segment, good vascularization, better quality of the bone, and a long vascular pedicle, but it is also associated with some disadvantages with regard to prosthetic rehabilitation because of its limited height. Improvement in bone height is necessary for ideal dental implant treatment of reconstructed mandibles.

Case Presentation: For two squamous cell carcinoma patients, mandibular bone reconstruction was performed secondarily with the peroneal flap after tumor resection. Read More

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December 2018

CAD/CAM and 3D-Printing Applications for Alveolar Ridge Augmentation.

Curr Oral Health Rep 2018 Jun 3;5(2):127-132. Epub 2018 May 3.

Assistant Professor of Periodontics and Director of Postdoctoral Periodontics, Department of Periodontics, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.

Purpose Of Review: CAD/CAM and 3D-printing are emerging manufacturing technologies in dentistry. In the field of alveolar ridge augmentation, graft customization utilizing these technologies can result in significant reduction of surgical time. A review of the literature on materials, techniques and applications of CAD/CAM and 3D-printing available for alveolar ridge augmentation was performed. Read More

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Clinical outcomes of polymeric sealant use in pulmonary resection: a systematic review and meta-analysis of randomized controlled trials.

J Thorac Dis 2018 Nov;10(Suppl 32):S3728-S3739

Division of Thoracic Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Prolonged alveolar air leak (PAL) is the most common adverse event following pulmonary resection. It carries morbidity for patients by increasing empyema risk, and for hospital administration with the cost of prolonged length of hospital stay (LOS). Intra-operative sealant technology is available to surgeons, and may decrease PAL. Read More

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November 2018

Exploratory analysis of introducing next-generation sequencing-based method to treatment-naive lung cancer patients.

J Thorac Dis 2018 Oct;10(10):5904-5912

Department of Thoracic Surgery, Zhangjiagang First Peoples Hospital, Suzhou 215000, China.

Background: The utilization of cancer-linked genetic alterations for categorizing patients against optimal treatment is becoming increasingly popular, especially in non-small cell lung cancer (NSCLC). However, disadvantages of the conventional techniques, such as the low throughput and limited detectable alteration types, lead to the demand of large-scale parallel sequencing for different forms of genetic variants.

Methods: We evaluated the potential of performing next-generation sequencing (NGS)-based methods in a cohort of 61 treatment-naive NSCLC patients to profile their driver mutations, using a panel consisting of 8 well-established driver genes of lung cancer. Read More

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October 2018

CT findings in pulmonary alveolar proteinosis: serial changes and prognostic implications.

J Thorac Dis 2018 Oct;10(10):5774-5783

Department of Radiology, Samsung Medical Center, Seoul, Korea.

Background: Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown origin, characterized by impaired surfactant metabolism. In some patients, residual disease is observed after treatment; notably, this may progress to end-stage pulmonary fibrosis. This study was performed to evaluate changes in lung abnormalities on serial CT scans performed on the lungs of patients diagnosed with PAP, as well as to identify factors that can be used to predict clinical improvement in PAP. Read More

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October 2018

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Nat Commun 2018 Nov 30;9(1):5088. Epub 2018 Nov 30.

JRG Translational Hematology of Congenital Diseases, Hannover Medical School, Hannover, Germany.

The increasing number of severe infections with multi-drug-resistant pathogens worldwide highlights the need for alternative treatment options. Given the pivotal role of phagocytes and especially alveolar macrophages in pulmonary immunity, we introduce a new, cell-based treatment strategy to target bacterial airway infections. Here we show that the mass production of therapeutic phagocytes from induced pluripotent stem cells (iPSC) in industry-compatible, stirred-tank bioreactors is feasible. Read More

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November 2018
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Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model.

Biol Pharm Bull 2018 ;41(12):1818-1823

Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University.

Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Read More

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January 2018

Autopsy in dengue encephalitis: An analysis of three cases.

Neurol India 2018 Nov-Dec;66(6):1721-1725

Department of Pathology and Neurology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Dengue viral infection with unusual presentations has been described in literature, but autopsy is rarely done and is only limited to some cases, based on the literature review. Here, we present the autopsy findings in three cases of dengue encephalitis. All the three patients clinically presented with signs of meningoencephalitis and were positive for dengue non-structural (NS) 1 antigen (Ag) in the serum and cerebrospinal fluid. Read More

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December 2018

[IgG4-related interstitial lung disease].

Medicina (B Aires) 2018 ;78(6):449-452

Servicio de Anatomía Patológica, Hospital Nacional Profesor Alejandro Posadas, El Palomar, Buenos Aires, Argentina.

IgG4-related disease is a heterogeneous group of diseases that can affect a single organ or manifest as a systemic disease. We present the case of a 55-yearold female, admitted for dry cough, fever, progressive dyspnea and respiratory failure. Chest CT showed areas of diffuse ground glass, reticular pattern and alveolar consolidation. Read More

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January 2018

Horizontal alveolar transport distraction osteogenesis followed by implant placement.

Int J Oral Maxillofac Surg 2018 Nov 28. Epub 2018 Nov 28.

Private Practice, Istanbul, Turkey. Electronic address:

Alveolar transport distraction osteogenesis (ATDO) is an alternative treatment method to vertical alveolar distraction osteogenesis in cases of large bony defects, especially when the bone is limited in size. ATDO was performed in 10 patients with 12 defects. The mean age of the patients was 39. Read More

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November 2018

Combined management of perianal rhabdomyosarcoma with chemotherapy, radical surgery, and irradiation: A series of three consecutive children.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Children's Hospital, Section of Pediatric Surgery, University of Helsinki, Finland.

Background And Aim: We describe a series of three successive patients with perianal rhabdomyosarcoma (PRMS) from 2014 to 2017 managed with combined chemotherapy, radical surgery, and radiotherapy.

Methods: Ethical consent was obtained. Data including tumor presentation, treatment, and survival was collected from hospital reports. Read More

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November 2018

Pathological Characterization of Lymphoma with Pulmonary Involvement in Cats.

J Comp Pathol 2018 Nov 19;165:6-12. Epub 2018 Oct 19.

Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Studies evaluating histological patterns of lung infiltration by lymphoma in cats are lacking. We evaluated retrospectively the histological patterns of 125 necropsy cases of feline lymphoma collected over a 12-year period. Of the 125 cases, 16 showed lung infiltration (12. Read More

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November 2018

Evaluating the possible association between systemic osteoporosis and periodontal disease progression in postmenopausal women.

Dis Mon 2018 Nov 27. Epub 2018 Nov 27.

Department of Conservative Dental Sciences, Division of Endodontics, College of Dentistry, Prince Sattam bin Abdulaziz University, P.O. Box:153, AlKharj 11942 Riyadh, Saudi Arabia.

To evaluate the association between systemic osteoporosis and periodontal diseases in postmenopausal women. A total of 300 women aged (50-70 years) were divided into an osteoporotic (OP) group (n = 150) and non-osteoporotic (NOP) group (n = 150) depending on BMD measured using (DXA) at the femoral neck and lumbar spine. Periodontal examination including PI, GI, PPD, and CAL was measured. Read More

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November 2018

B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.

Cell Rep 2018 Dec;25(10):2775-2783.e3

Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ 07101, USA. Electronic address:

Emphysema results in destruction of alveolar walls and enlargement of lung airspaces and has been shown to develop during helminth infections through IL-4R-independent mechanisms. We examined whether interleukin 17A (IL-17A) may instead modulate development of emphysematous pathology in mice infected with the helminth parasite Nippostrongylus brasiliensis. We found that transient elevations in IL-17A shortly after helminth infection triggered subsequent emphysema that destroyed alveolar structures. Read More

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December 2018

Tilmicosin modulates the innate immune response and preserves casein production in bovine mammary alveolar cells during Staphylococcus aureus infection.

J Anim Sci 2018 Dec 4. Epub 2018 Dec 4.

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México.

Tilmicosin is an antimicrobial agent used to treat intramammary infections against S. aureus and has clinical anti-inflammatory effects. However, the mechanism by which it modulates the inflammatory process in the mammary gland is unknown. Read More

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December 2018

Preservation of Dental Sockets Filled with Composite Bovine Bone. A Single-Blind Randomized Clinical Trial.

Braz Dent J 2018 Nov-Dec;29(6):583-591

Implant Dentistry Post-Graduation Program, School of Dentistry and Research Center SLMANDIC - Faculdade de Medicina e Odontologia e Centro de Pesquisas Odontológicas São Leopoldo Mandic, Campinas, SP, Brazil.

The purpose of this study was to evaluate the preservation of alveolar dimensions in human fresh extraction sockets filled with a composite bovine bone graft by means of design of single-blind randomized clinical trial. Forty participants had monoradicular teeth extracted (one teeth in each participant), and after were randomly divided into 2 groups: individuals whose fresh sockets were filled with the composite heterologous bone graft (Biomaterial Group), or with blood clot (Control Group). After extraction, the fresh sockets were measured at their greatest mesiodistal (MD) and bucco-lingual/palatal (BL/P) distance. Read More

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January 2018
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Dentoalveolar Evaluation of Lower Incisors by CBCT after Treatment with Herbst Appliance.

Braz Dent J 2018 Nov-Dec;29(6):562-568

Department of Orthodontics, Universidade Positivo, Curitiba, PR, Brazil.

This study aimed to evaluate the effects of the Herbst appliance on the proclination and protrusion of the lower incisors, and to verify if the device causes alveolar bone loss in the anterior region of the mandible. This is a retrospective study. The sample consisted of 35 individuals. Read More

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February 2018
3 Reads

Severe iron-deficiency anemia as initial manifestation of pulmonary hemosiderosis in a child.

Einstein (Sao Paulo) 2018 Nov 29;16(4):eRC4505. Epub 2018 Nov 29.

Serviço de Pediatria Médica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Idiopathic pulmonary hemosiderosis is a potentially fatal disease that results from episodes of alveolar hemorrhage of unknown origin. The clinical spectrum is varied, and anemia may constitute the only manifestation of illness, preceding other signs and symptoms by several months. We present the case of a 4 year-old child presenting with fever, vomiting and prostration, associated with pallor. Read More

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November 2018
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THE ORTHODONTIC APPLIANCES FOR TREATMENT OF OPEN BITE PROPRIETARY CONSTRUCTION.

Georgian Med News 2018 Oct(283):30-34

O.O. Bogomolets National Medical University, Kiev, Ukraine.

In orthodontic practice, removable orthodontic devices are used to treat anomalies and deformations of the dentoalveolar apparatus during the period of the transition occlusion. The creation of new orthodontic appliances or the modification of existing appliances is actual today. The aim is to create easy-to-use therapeutical-prophilaxis orthodontic appliances that can be used to treat open bite and anomalies of the individual teeth position. Read More

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October 2018
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Finite Element Stress Analysis of Applied Forces to Implants and Supporting Tissues Using the "All-on-Four" Concept with Different Occlusal Schemes.

J Prosthodont 2018 Dec 4. Epub 2018 Dec 4.

Department of Prosthodontics, Akdeniz University Faculty of Dentistry, Antalya, Türkiye.

Purpose: The aim of this study was to evaluate stress distributions on implants and alveolar bone due to occlusal load produced during chewing by prostheses prepared according to the All-on-Four concept with different occlusal schemes using a finite element analysis method.

Materials And Methods: On standard jaw models, teeth were set in accordance with the basic standards of canine-guided occlusion, group function occlusion, bilateral balanced occlusion (BBO), lingualized occlusion, and monoplane occlusion schemes. Three-dimensional (3D) images of these models were obtained using a surface scanner. Read More

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December 2018

Comparison of in vivo lung morphometry models from 3D multiple b-value He and Xe diffusion-weighted MRI.

Magn Reson Med 2018 Dec 4. Epub 2018 Dec 4.

POLARIS, Academic Unit of Radiology, Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

Purpose: To compare in vivo lung morphometry parameters derived from theoretical gas diffusion models, the cylinder model and stretched exponential model, in a range of acinar microstructural length scales encountered in healthy and diseased lungs with He and Xe diffusion-weighted MRI.

Methods: Three-dimensional multiple b-value He and Xe diffusion-weighted MRI was acquired with compressed sensing at 1.5 T from 51 and 31 subjects, respectively, including healthy volunteers, ex-smokers, idiopathic pulmonary fibrosis, and chronic obstructive pulmonary disease patients. Read More

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December 2018

Russell-Silver syndrome with cleft palate: a case report.

Oral Maxillofac Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi, 755-8505, Japan.

Background: Russell-Silver syndrome (RSS) is characterized by intrauterine growth retardation, short stature without postnatal catch-up growth, and an inverted triangular face with relative macrocephaly. There have been few case reports of RSS with cleft palate, in which perioperative problems such as difficult intubation due to trismus and impossibility to wear a mouth gag due to growth failure of the mandible were described. The case of a female RSS patient with cleft palate who underwent palatoplasty is reported. Read More

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December 2018
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Correlation of clinical parameters with imaging findings to confirm the diagnosis of fat embolism syndrome.

Int J Burns Trauma 2018 20;8(5):135-144. Epub 2018 Oct 20.

Department of Radiology, Hamad Medical Corporation Doha, Qatar.

Background: Fat embolism syndrome (FES) is a multi-organ dysfunction caused by the fat emboli. The diagnostic of FES remains a challenge for clinicians. The clinical criteria including those of Gurd's and Wilson's although universally used for its diagnosis are not specific. Read More

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October 2018
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[Effect of acupuncture on TGF-β1/Smads pathway in mice with airway remodeling mic].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1372-1377

Department of Otolaryngology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Objective: To investigate the effect of acupuncture on TGF-β1/Smads signaling pathway in the lung tissue of mice with airway remodeling.

Methods: Thirty specific pathogen-free mice were randomly divided into blank group, model group and acupuncture group (=10). Mouse models of asthma were established in the model group and the acupuncture group, and the mice in the latter group received 7 acupuncture therapies (at bilateral Fei Shu, Da Zhui and Zu Sanli, 20 min each time) every other day, starting on the 10th day after the modeling. Read More

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November 2018

Immediate dental implant placement in calvarial bone grafts to rehabilitate the severely resorbed edentulous maxilla: A prospective pilot study.

J Craniomaxillofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery (Head Dr. Jurjen Schortinghuis), Treant Hospital, Emmen-Stadskanaal, The Netherlands. Electronic address:

Purpose: The aim of this study was to describe the surgical technique of immediate dental implant placement in calvarial grafts for augmentation of the severely resorbed maxilla and to assess the treatment results.

Methods: In 13 patients the maxilla was augmented with calvarial bone followed by simultaneous dental implant placement (total: 68 implants). In the frontal "knife edge" region, implants were inserted in the buccal plated area. Read More

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November 2018

IL-13 attenuates early local CXCL2-dependent neutrophil recruitment for Candida albicans clearance during a severe murine systemic infection.

Immunobiology 2018 Nov 24. Epub 2018 Nov 24.

Department of Infection Control, Fukushima Medical University, Hikarigaoka, Fukushima, 960-1295, Japan.

To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13 mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative real-time PCR, a multiple ELISA system, and morphological cell differentiation. The IL-13 group exhibited a lower CFU number in the kidneys at 4 days and survived longer than the control mice, which was accompanied by significantly higher expression of C-X-C motif ligand 2 (CXCL2), IFN-γ, and polymorphonuclear neutrophils (PMNs) in the infected kidneys. Read More

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November 2018