1,445 results match your criteria Alternatives to laboratory animals : ATLA[Journal]


An Overview of Current Alternative Models for Use in the Context of Prostate Cancer Research.

Altern Lab Anim 2020 Jul 2:261192920929701. Epub 2020 Jul 2.

Center for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Prostate cancer is one of the most commonly diagnosed cancers worldwide, particularly in elderly populations. To mitigate the expected increase in prostate cancer-related morbidity and mortality as a result of an expanding aged population, safer and more effective therapeutics are required. To this end, plenty of research is focusing on the mechanisms underlying cancer initiation and development, the metastatic process and on the discovery of new therapies. Read More

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http://dx.doi.org/10.1177/0261192920929701DOI Listing

Out with the Old, In with the New!

Authors:
Susan Trigwell

Altern Lab Anim 2020 01;48(1):3-4

ATLA Editorial Office, FRAME, Nottingham, UK. Email: org. uk.

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http://dx.doi.org/10.1177/0261192920915351DOI Listing
January 2020

The Skin Model as an Alternative Tool for the Efficacy and Safety Evaluation of Topical Products.

Altern Lab Anim 2020 Jan;48(1):10-22

Kosmoscience Group, Campinas, São Paulo, Brazil.

The development of alternative approaches for safety and efficacy testing that avoid the use of animals is a worldwide trend, which relies on the improvement of current models and tools so that they better reproduce human biology. Human skin from elective plastic surgery is a promising experimental model to test the effects of topically applied products. As the structure of native skin is maintained, including cell population (keratinocytes, melanocytes, Langerhans cells and fibroblasts) and dermal matrix (containing collagen, elastin, glycosaminoglycans, etc. Read More

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http://dx.doi.org/10.1177/0261192920914193DOI Listing
January 2020

Conference Diary.

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Altern Lab Anim 2020 May 27:261192920927659. Epub 2020 May 27.

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http://dx.doi.org/10.1177/0261192920927659DOI Listing

Devising a Tier-based Skin Sensitisation Screening Strategy for Personal Care and Cosmetic Products.

Altern Lab Anim 2020 May 22:261192920924401. Epub 2020 May 22.

Cardno ChemRisk, San Francisco, CA, USA.

Concerns regarding the use of potential skin sensitisers in personal care and cosmetic products continue to grow. The goal of this study was to develop a proof-of-concept tier-based screening strategy for the assessment of skin sensitisation potential by using non-animal methodologies. As a case example, this screening framework was applied to three WEN® by Chaz Dean cleansing conditioners. Read More

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http://dx.doi.org/10.1177/0261192920924401DOI Listing

Development of a Synthetic Training Model for Canine Thoracocentesis.

Altern Lab Anim 2020 May 22:261192920924408. Epub 2020 May 22.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Thoracocentesis, a procedure in which air or fluid is removed from the pleural space, is used to relieve respiratory distress, and as a diagnostic procedure in human and veterinary medicine. Veterinary students commonly learn and practice the procedure on canine cadavers which are in limited supply and are not amenable to long-term storage and use. Practicing thoracocentesis on a cadaveric model also provides limited feedback indicative of success and/or procedural complications. Read More

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http://dx.doi.org/10.1177/0261192920924408DOI Listing

The Quality of Reporting Raises Questions on the Experimental Validity of Animal Studies Conducted in India and Sri Lanka: Preliminary Analysis of a Systematic Survey.

Altern Lab Anim 2020 May 19:261192920923105. Epub 2020 May 19.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

The quality of animal experiments in terms of appropriate reporting is a concern, particularly with regard to their validity and the recording of the measures taken to reduce various types of bias. A systematic survey of 1371 and 236 publications from India and Sri Lanka, respectively, which were published between 1905 and 2017 and indexed in NCBI-PubMed, Cinhal, MEDLINE and Scopus, was carried out. The level of detail in the descriptions of animals used and the measures taken to reduce bias were analysed in each article. Read More

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http://dx.doi.org/10.1177/0261192920923105DOI Listing
May 2020
1.592 Impact Factor

CAAT News & Views.

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Altern Lab Anim 2020 May 7:261192920921969. Epub 2020 May 7.

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http://dx.doi.org/10.1177/0261192920921969DOI Listing

It's Time to Reconsider .

Authors:
Michael Balls

Altern Lab Anim 2020 Jan 21;48(1):40-46. Epub 2020 Apr 21.

Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.

In the 60 years since the publication of , the Three Rs (, , ) proposed by William Russell and Rex Burch have gradually been accepted throughout the world as ways of facing up to the ethical and scientific dilemmas involved in animal experimentation. However, the scale of animal use and the use of animals as models of humans has continued, seemingly almost unchallenged in much of the scientific community, despite the warnings about models, species differences and human variation spelled out in the . In this , it is proposed that it is time to move away from the animal welfare focus of the Three Rs, in favour of a wider concept of humanity, which also embraces human welfare. Read More

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http://dx.doi.org/10.1177/0261192920911339DOI Listing
January 2020

Factors Related to Animal Neglect in Brazilian Laboratories.

Altern Lab Anim 2020 Jan 11;48(1):29-39. Epub 2020 Apr 11.

Animal Welfare Laboratory (LABEA), Federal University of Paraná (UFPR), Curitiba, Brazil.

Our objectives were to identify the prevalence of negligence of laboratory animals in Brazil, to determine the primary factors associated with its occurrence and to suggest prevention strategies. A questionnaire was made available online between October 2015 and March 2016. A total of 116 respondents with experience in the use of laboratory animals and/or the use of alternative methods answered the questionnaire. Read More

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http://dx.doi.org/10.1177/0261192920911341DOI Listing
January 2020

Publication and Citation Analysis of Medical Doctors' Residency Master's Theses Involving Animal Experiments on Rats in Turkey.

Altern Lab Anim 2020 Jan 20;48(1):23-28. Epub 2020 Mar 20.

Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

The number of non-human animals used in research has increased in line with advances in medical technology, although it has previously been shown that these experiments demonstrate poor human utility. This study aimed to determine the effectiveness of animal studies on rats that were performed as part of medical doctors' residency master's theses prepared in Turkey between January 2006 and December 2015. The number of thesis-derived published papers from each year, as well as the subsequent citation rate of these papers, was determined. Read More

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http://dx.doi.org/10.1177/0261192920907226DOI Listing
January 2020

The 18th FRAME Annual Lecture, October 2019: Human Trials in Pharmacology.

Authors:
Blanca Rodriguez

Altern Lab Anim 2019 Nov-Dec;47(5-6):221-227

Department of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.

Safety and efficacy testing is a crucial part of the drug development process, and several different methods are used to obtain the necessary data (e.g. testing, animal trials and clinical trials). Read More

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http://dx.doi.org/10.1177/0261192919896356DOI Listing

2019 - A Year of Anniversaries.

Authors:
Susan Trigwell

Altern Lab Anim 2019 Nov-Dec;47(5-6):165-166

ATLA Editorial Office FRAME Nottingham UK Email: org. uk.

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http://dx.doi.org/10.1177/0261192919900042DOI Listing
February 2020

Conference Diary.

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Altern Lab Anim 2019 Nov-Dec;47(5-6):228

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http://dx.doi.org/10.1177/0261192919900041DOI Listing
February 2020

News & Views.

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Altern Lab Anim 2019 Nov-Dec;47(5-6):167-169

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http://dx.doi.org/10.1177/0261192919900428DOI Listing
February 2020

CAAT News & Views.

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Altern Lab Anim 2019 Nov-Dec;47(5-6):170-173

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http://dx.doi.org/10.1177/0261192919900427DOI Listing
February 2020

An Estimate of the Number of Animals Used for Scientific Purposes Worldwide in 2015.

Altern Lab Anim 2019 Nov-Dec;47(5-6):196-213

Cruelty Free International Trust, London, UK.

Few attempts have been made to estimate the global use of animals in experiments, since our own estimated figure of 115.2 million animals for the year 2005. Here, we provide an update for the year 2015. Read More

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http://dx.doi.org/10.1177/0261192919899853DOI Listing

The Overt and Hidden Use of Animal-Derived Products in Alternative Methods for Skin Sensitisation: A Systematic Review.

Altern Lab Anim 2019 Nov-Dec;47(5-6):174-195. Epub 2020 Jan 4.

Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

methods that can replace animal testing in the identification of skin sensitisers are now a reality. However, as cell culture and related techniques usually rely on animal-derived products, these methods may be failing to address the complete replacement of animals in safety assessment. The objective of this study was to identify the animal-derived products that are used as part of methods for skin sensitisation testing. Read More

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http://dx.doi.org/10.1177/0261192919896361DOI Listing

The Emergence and Early Fate of the Three Rs Concept.

Altern Lab Anim 2019 Nov-Dec;47(5-6):214-220. Epub 2020 Jan 4.

Department of History, University of Maryland, College Park, MD, USA.

In the 60th year since the publication of by W.M.S. Read More

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http://dx.doi.org/10.1177/0261192919896352DOI Listing

The Relevance of , and Non-human Primate Based Approaches to Clinical Research on Major Depressive Disorder.

Altern Lab Anim 2019 Jul-Sep;47(3-4):128-139

Centro de Filosofia das Ciências da Universidade de Lisboa, Lisboa, Portugal.

Major depressive disorder (MDD) is the most severe form of depression and the leading cause of disability worldwide. When considering research approaches aimed at understanding MDD, it is important that their effectiveness is evaluated. Here, we assessed the effectiveness of original studies on MDD by rating their contributions to subsequent medical papers on the subject, and we compared the respective contribution of findings from non-human primate (NHP) studies and from human-based or research approaches. Read More

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http://dx.doi.org/10.1177/0261192919885578DOI Listing
December 2019

A Focus on .

Authors:
Susan Trigwell

Altern Lab Anim 2019 Jul-Sep;47(3-4):109

ATLA Editorial Office, FRAME, Nottingham, UK.

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http://dx.doi.org/10.1177/0261192919886664DOI Listing
December 2019

Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to Eye Irritation Testing.

Altern Lab Anim 2019 Jul-Sep;47(3-4):140-157

Institute of Agrobiological Sciences (NIAS), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan.

Collagen vitrigel membranes (CVMs) comprising high-density collagen fibrils equivalent to connective tissues have been widely used in cell culture applications. A human corneal epithelium (hCE) model was previously developed by the Takezawa group, by culturing HCE-T cells (derived from hCE cells) on a CVM scaffold in a chamber that provided an air-liquid interface culture system. This hCE model was used to establish a new test method, known as the Vitrigel-Eye Irritancy Test (Vitrigel-EIT) method, which can be used to estimate the ocular irritation potential of test chemicals by analysing relative changes in transepithelial electrical resistance (TEER) over time. Read More

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http://dx.doi.org/10.1177/0261192919886665DOI Listing
December 2019

CAAT News & Views.

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Altern Lab Anim 2019 Jul-Sep;47(3-4):113-115. Epub 2019 Nov 8.

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http://dx.doi.org/10.1177/0261192919885575DOI Listing
November 2019

Non-pooled Human Platelet Lysate: A Potential Serum Alternative for Cell Culture.

Altern Lab Anim 2019 Jul-Sep;47(3-4):116-127. Epub 2019 Nov 8.

Department of Bioprocessing & Bioanalytics, Fraunhofer Institute for Biomedical Engineering, Sulzbach/Saar, Germany.

Serum supplementation is crucial in cell culture to provide all the essential nutrients needed for cellular processes. Fetal bovine serum (FBS) is considered the 'gold standard', but its production raises serious ethical concerns. Human-derived alternatives to FBS exist in the form of human platelet lysates (hPLs) or human AB serum (ABS). Read More

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http://dx.doi.org/10.1177/0261192919882516DOI Listing
December 2019

News & Views.

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Altern Lab Anim 2019 Jul-Sep;47(3-4):110-112. Epub 2019 Nov 5.

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http://dx.doi.org/10.1177/0261192919885576DOI Listing
November 2019

The 2020 Lush Prize: Call for Nominations.

Authors:
Craig Redmond

Altern Lab Anim 2019 Jul-Sep;47(3-4):158-159. Epub 2019 Oct 17.

Lush Prize, Ethical Consumer Research Association, Manchester, UK.

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http://dx.doi.org/10.1177/0261192919882537DOI Listing
December 2019

News & Views.

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Altern Lab Anim 2019 May 18;47(2):60-62. Epub 2019 Jun 18.

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http://dx.doi.org/10.1177/0261192919856805DOI Listing

FRAME 50th Anniversary Symposium, July 2019.

Authors:
Amy Beale

Altern Lab Anim 2019 May 4;47(2):93. Epub 2019 Sep 4.

FRAME, Nottingham, UK.

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http://dx.doi.org/10.1177/0261192919869382DOI Listing

Pushing the Partnership Forward.

Authors:
Susan Trigwell

Altern Lab Anim 2019 May 13;47(2):59. Epub 2019 Aug 13.

ATLA Editorial Office, FRAME, Nottingham, UK.

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http://dx.doi.org/10.1177/0261192919866570DOI Listing

Experimental Animal Use in Turkey: A Comparison with Other Countries.

Altern Lab Anim 2019 May 9;47(2):82-92. Epub 2019 Aug 9.

Department of History of Veterinary Medicine and Deontology, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey.

The legal structure that governs animal use in Turkey is in line with that of the European Union (EU). In 2004, legislation on the use of animals for experimental and other scientific purposes was established in Turkey for the first time. The present study aimed to compare the data on experimental animal use in Turkey (during the period 2008-2017) with similar reports from selected countries (the United States, Australia, Canada and the EU). Read More

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http://dx.doi.org/10.1177/0261192919861874DOI Listing

Conference Diary.

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Altern Lab Anim 2019 May 31;47(2):106. Epub 2019 Jul 31.

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http://dx.doi.org/10.1177/0261192919865061DOI Listing

Reference Gene Validation for Quantitative Real-time PCR Studies in Amphibian Kidney-derived A6 Epithelial Cells.

Altern Lab Anim 2019 May 23;47(2):63-70. Epub 2019 Jul 23.

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Quantitative real-time polymerase chain reaction is a widely used technique that relies on reference genes for the normalisation of gene expression. These reference genes are constitutively expressed and must remain stable across all samples and treatments. Stability of housekeeping genes may vary and must be optimised for a specific tissue, sample or cell line. Read More

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http://dx.doi.org/10.1177/0261192919862936DOI Listing

Brazil Moves Toward the Replacement of Animal Experimentation.

Altern Lab Anim 2019 May 19;47(2):71-81. Epub 2019 Jul 19.

Laboratory of Education and Research in In Vitro Toxicology - Tox In, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, State of Goiás, Brazil.

In Brazil, efforts towards the regulatory acceptance and implementation of innovative methods to replace experimental animal use in various fields began to gather force in 2008, with the approval of (the Arouca Law). This law represented a milestone, as it created the National Council for the Control of Animal Experimentation (CONCEA) to deal with the ethical and legal issues related to the use of laboratory animals. In 2014, CONCEA put together a framework for expanding the implementation of non-animal methodologies for use in research and education. Read More

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http://dx.doi.org/10.1177/0261192919856806DOI Listing
May 2019
1 Read

Retinal Organ Cultures as Alternative Research Models.

Altern Lab Anim 2019 Mar;47(1):19-29

2 Experimental Eye Research, University Eye Hospital, Ruhr-University Bochum, Bochum, Germany.

organ cultures represent unique research models, as they combine the advantages of cell cultures with those of animal models. Being able to mimic situations through the use of organ cultures provides an excellent opportunity to investigate cellular processes, molecular pathways and cell-cell interactions, as well as structural and synaptic organisation. Human and animal organ cultures are now well established and comprise sensitive, easy-to-manipulate experimental systems that raise minimal ethical concerns. Read More

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http://dx.doi.org/10.1177/0261192919840092DOI Listing
March 2019
2 Reads

Short-term and Long-term Exposure of the MucilAir™ Model to Polycyclic Aromatic Hydrocarbons.

Altern Lab Anim 2019 Mar 30;47(1):9-18. Epub 2019 Apr 30.

1 Department of Genetic Toxicology and Nanotoxicology, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.

Cells grown in monocultures are widely used to model lung tissue. As a result of these culture conditions, these cells exhibit poor morphological similarity to those present in lung tissue. MucilAir™, a 3-D model comprising human basal, goblet and ciliated cells, represents a fully differentiated respiratory epithelium that can be used as an alternative and a more realistic system. Read More

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http://dx.doi.org/10.1177/0261192919841484DOI Listing
March 2019
3 Reads

CAAT News & Views.

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Altern Lab Anim 2019 Mar;47(1):7-8

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http://dx.doi.org/10.1177/0261192919841709DOI Listing
March 2019
2 Reads

Conference Diary.

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Altern Lab Anim 2019 Mar;47(1):41

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http://dx.doi.org/10.1177/0261192919841708DOI Listing
March 2019
2 Reads

Conscientious Objection to Animal Testing: A Preliminary Survey Among Italian Medical and Veterinary Students.

Altern Lab Anim 2019 Mar;47(1):30-38

6 Department of Health Science (DISSAL), University of Genoa, Genoa, Italy.

The use of animals for educational and research purposes is common in both veterinary and human medicine degree courses, and one that involves important ethical considerations. The aim of this study was to assess the extent of differences between the knowledge and attitudes of veterinary students and medical students on animal bioethics, on alternative strategies and on their right to conscientiously object to animal experimentation. To this end, a questionnaire was completed by 733 students (384 human medicine students (HMS) and 349 veterinary medicine students (VMS)). Read More

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http://dx.doi.org/10.1177/0261192919840452DOI Listing
March 2019
2 Reads

News & Views.

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Altern Lab Anim 2019 Mar;47(1):5-6

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http://dx.doi.org/10.1177/0261192919841710DOI Listing
March 2019
2 Reads

Evolves to the Next Stage: FRAME is partnering with SAGE Publishing to take ATLA forward.

Authors:
Susan Trigwell

Altern Lab Anim 2019 Mar;47(1):3-4

ATLA Editorial Office, FRAME, Nottingham, UK.

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http://dx.doi.org/10.1177/0261192919842952DOI Listing
March 2019
2 Reads

Ten years of REACH - An animal protection perspective.

Authors:
Katy Taylor

Altern Lab Anim 2018 Dec;46(6):347-373

European Coalition to End Animal Experiments (ECEAE( and Cruelty Free International Trust, London, UK.

It has now been 11 years since the EU's new chemicals legislation (Regulation No. 1907/2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals [REACH]) came into force. Two important statements in the REACH Regulation in relation to animal testing and alternatives are: Article 1(1), which states that one of its purposes is to promote alternative methods; and Article 25(1), which states that animal testing should be used as a last resort. Read More

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http://dx.doi.org/10.1177/026119291804600610DOI Listing
December 2018
2 Reads

Phase 0, including microdosing approaches: Applying the Three Rs and increasing the efficiency of human drug development.

Altern Lab Anim 2018 Dec;46(6):335-346

Independent Consultant, Norwich, UK.

Phase 0 approaches, including microdosing, involve the use of sub-therapeutic exposures to the tested drugs, thus enabling safer, more-relevant, quicker and cheaper first-in-human (FIH) testing. These approaches also have considerable potential to limit the use of animals in human drug development. Recent years have witnessed progress in applications, methodology, operations, and drug development culture. Read More

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http://dx.doi.org/10.1177/026119291804600603DOI Listing
December 2018
5 Reads

The application of humane endpoints and humane killing methods in animal research proposals: A retrospective review.

Altern Lab Anim 2018 Dec;46(6):317-333

Newcastle University, The Medical School, Comparative Biology Centre, Newcastle upon Tyne, UK.

Refinement refers to the use of methods that help to minimise animal suffering in the laboratory. Research in this area has increased significantly over the past two decades. However, the extent to which refinements are applied in practice is uncertain. Read More

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http://dx.doi.org/10.1177/026119291804600606DOI Listing
December 2018
3 Reads

Where to draw the line? Should the age of protection for zebrafish be lowered?

Authors:
Lynne U Sneddon

Altern Lab Anim 2018 Dec;46(6):309-311

University of Liverpool, Liverpool, UK.

Zebrafish are not protected by legislation in many countries until they reach the first feed stage, typically at five days post-fertilisation. If they exhibit similar responses to adults when responding to pain and other stimuli should they be given more protection? Read More

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http://dx.doi.org/10.1177/026119291804600605DOI Listing
December 2018
2 Reads

Does the stress of laboratory life and experimentation on animals adversely affect research data? A critical review.

Authors:
Jarrod Bailey

Altern Lab Anim 2018 Nov;46(5):291-305

Cruelty Free International, London, UK.

Recurrent acute and/or chronic stress can affect all vertebrate species, and can have serious consequences. It is increasingly and widely appreciated that laboratory animals experience significant and repeated stress, which is unavoidable and is caused by many aspects of laboratory life, such as captivity, transport, noise, handling, restraint and other procedures, as well as the experimental procedures applied to them. Such stress is difficult to mitigate, and lack of significant desensitisation/habituation can result in considerable psychological and physiological welfare problems, which are mediated by the activation of various neuroendocrine networks that have numerous and pervasive effects. Read More

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http://dx.doi.org/10.1177/026119291804600501DOI Listing
November 2018
2 Reads

Severity classification of surgical procedures and application of health monitoring strategies in animal research proposals: A retrospective review.

Altern Lab Anim 2018 Nov;46(5):273-289

Newcastle University, The Medical School, Comparative Biology Centre, Newcastle upon Tyne, UK.

Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon the animals used. In an effort to reduce these harms, research on refinement has increased significantly over the past 20 years. However, the extent to which these efforts have helped to reduce the severity of the research procedures, and thus animal suffering, is uncertain. Read More

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November 2018
3 Reads

A comparison of pyrogen detection tests in the quality control of meningococcal conjugate vaccines: The applicability of the Monocyte Activation Test.

Altern Lab Anim 2018 Nov;46(5):255-272

Departamento de Controle de Qualidade, Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

The meningococcal C conjugate vaccine (MenCC) is an interesting model with which to test the efficacy of the Monocyte Activation Test (MAT) as an alternative method of pyrogen testing in the quality control of vaccines. The MenCC that has been produced by Bio-Manguinhos in Brazil is in the final development stage, and, as recommended in the guidelines for MenCC production, its pyrogen content must be determined by using the Limulus Amoebocyte Lysate (LAL) assay and the Rabbit Pyrogen Test (RPT). This represents an ideal opportunity to compare LAL and RPT data with data obtained by using a MAT system with cryopreserved whole blood and IL-6/IL-1β as marker readouts. Read More

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http://dx.doi.org/10.1177/026119291804600506DOI Listing
November 2018
42 Reads

Electronic cigarettes: can dependable public health policies be developed and applied without relevant and reliable risk assessments?

Altern Lab Anim 2018 Nov;46(5):245-248

Independent Consultant, Norwich, UK.

The use of electronic cigarettes is being encouraged as a way of escaping from the harm resulting from conventional tobacco smoking, while scant attention is being paid to the long-term risks of inhaling electronic cigarette vapour. More information is needed for an acceptable risk assessment, from integrated non-animal testing and sound clinical investigations. Read More

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http://dx.doi.org/10.1177/026119291804600504DOI Listing
November 2018
2 Reads

Brazil starts to ban animal use in higher education: A positive and progressive development.

Altern Lab Anim 2018 Sep;46(4):235-239

1R Institute of Promotion and Research for the Replacement of Animal Experimentation, Brazil.

The Brazilian government has published a resolution that bans animal use in some practical classes within undergraduate and high school technical education from April 2019. Resolution No. 38/2018, issued by the National Council for the Control of Animal Experimentation (CONCEA), bans the killing of animals for dissection purposes and animal experiments in practical classes that do not involve the acquisition of new skills. Read More

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http://dx.doi.org/10.1177/026119291804600402DOI Listing
September 2018
34 Reads

In vitro human tissues via multi-material 3-D bioprinting.

Altern Lab Anim 2018 Sep;46(4):209-215

Wyss Institute for Biologically Inspired Engineering and Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.

This paper highlights the foundational research on multi-material 3-D bioprinting of human tissues, for which the Lewis Bioprinting team at Harvard University was awarded the 2017 Lush Science Prize. The team's bioprinting platform enables the rapid fabrication of 3-D human tissues that contain all of the essential components found in their in vivo counterparts: cells, vasculature (or other tubular features) and extracellular matrix. The printed 3-D tissues are housed within a customised perfusion system and are subjected to controlled microphysiological environments over long durations (days to months). Read More

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http://dx.doi.org/10.1177/026119291804600404DOI Listing
September 2018
4 Reads