487,577 results match your criteria Alternative medicine review : a journal of clinical therapeutic[Journal]


The Association between Chronicity of Migraine and Complementary and Alternative Medication Use: The Turkish Perspective.

Eur Neurol 2019 Apr 23;81(1-2):24-29. Epub 2019 Apr 23.

Department of Neurology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey,

Background And Purpose: The term of Complementary and Alternative Medication (CAM) is described by patients as all types of practices to prevent or treat illnesses, which are not currently considered as a part of conventional medicine. Although the advance in treatment for migraine, some patients prefer CAM therapies due to their concerns about conventional therapies. The aim of this study was to evaluate the association between CAM use and chronicity of migraine among Turkish migraineurs. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/499910
Publisher Site
http://dx.doi.org/10.1159/000499910DOI Listing
April 2019
1 Read

Chronic recording and electrochemical performance of amorphous silicon carbide-coated Utah electrode arrays implanted in rat motor cortex.

J Neural Eng 2019 Apr 23. Epub 2019 Apr 23.

Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas, UNITED STATES.

Clinical applications of implantable microelectrode arrays are currently limited by device failure due to, in part, mechanical and electrochemical failure modes. To overcome this challenge, there is significant research interest in the exploration of novel array architectures and encapsulation materials. Amorphous silicon carbide (a-SiC) is biocompatible and corrosion resistant, and has recently been employed as a coating on biomedical devices including planar microelectrode arrays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1741-2552/ab1bc8DOI Listing

Acupuncture for Primary Insomnia: An Updated Systematic Review of Randomized Controlled Trials.

J Altern Complement Med 2019 Apr 23. Epub 2019 Apr 23.

1 Beijing University of Chinese Medicine, Beijing, China.

Acupuncture as one of the alternative therapies for insomnia is widely used in Asia and increasingly employed in western countries. To provide updated evidence from randomized controlled trials (RCTs) on the effectiveness and safety of acupuncture for primary insomnia. A comprehensive literature search in 11 databases was conducted from January 2008 to October 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/acm.2018.0046DOI Listing

Microencapsulated Parathyroid Allotransplantation in the Omental Tissue.

Artif Organs 2019 Apr 23. Epub 2019 Apr 23.

Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.

Background: Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathormone level. Conventional treatment requires life-long medication, and daily drug usage has some side-effects. To avoid this circumstance, transplantation is an alternative and curative option. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aor.13475DOI Listing

Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli.

PLoS One 2019 23;14(4):e0215892. Epub 2019 Apr 23.

Drug Discovery Program, CRUK Beatson Institute, Glasgow, United Kingdom.

Gene synthesis services have largely superseded traditional PCR methods for the generation of cDNAs destined for bacterial expression vectors. This, in turn, has increased the application of codon-optimized cDNAs where codons rarely used by Escherchia coli are replaced with common synonymous codons to accelerate translation of the target. A markedly accelerated rate of expression often results in a significant uplift in the levels of target protein but a substantial proportion of the enhanced yield can partition to the insoluble fraction rendering a significant portion of the gains unavailable for native purification. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215892PLOS

Interactions between a population of fallow deer (Dama dama), humans and crops in a managed composite temperate landscape in southern Sweden: Conflict or opportunity?

PLoS One 2019 23;14(4):e0215594. Epub 2019 Apr 23.

Grimsö Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences, Riddarhyttan, Sweden.

Landscapes composed of agricultural land mixed with forest are desirable since they provide a wide range of diversified ecosystem services, unlike specialized agricultural landscapes, but that creates a trade-off between these land uses since wildlife usually feed on crops and reduce yields. In Nordic countries, where human population density is low and game hunting can be a viable economic alternative, mixed landscape systems are particularly interesting. To evaluate the economic sustainability of such systems we need to quantify wildlife damage to crops. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215594PLOS

Middle-way flexible docking: Pose prediction using mixed-resolution Monte Carlo in estrogen receptor α.

PLoS One 2019 23;14(4):e0215694. Epub 2019 Apr 23.

Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, United States of America.

There is a vast gulf between the two primary strategies for simulating protein-ligand interactions. Docking methods significantly limit or eliminate protein flexibility to gain great speed at the price of uncontrolled inaccuracy, whereas fully flexible atomistic molecular dynamics simulations are expensive and often suffer from limited sampling. We have developed a flexible docking approach geared especially for highly flexible or poorly resolved targets based on mixed-resolution Monte Carlo (MRMC), which is intended to offer a balance among speed, protein flexibility, and sampling power. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215694PLOS
April 2019
1 Read

Postmortem imaging in goats using computed tomography with air as a negative contrast agent.

PLoS One 2019 23;14(4):e0215758. Epub 2019 Apr 23.

Laboratory of Veterinary Epidemiology and Economics, Warsaw University of Life Sciences-SGGW, Warsaw, Poland.

Purpose: Evaluation of the usefulness of air as a negative contrast medium of blood vessels in goats in post mortem computed tomography (PMCT) and establishing the protocol with appropriate doses and timing of the contrast medium administration.

Methods: Thirty three goats were euthanized 10 to 300 min before the study. First, in 3 goats air was administered into the left or right common carotid artery at dose of 60, 100 and 120 ml/kg, and after each dose PMCT was performed in lateral recumbency. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215758PLOS

Midterm Results of Transaxillary Occluder Device Closure of Perimembranous Ventricular Septal Defect Guided Solely by Transesophageal Echocardiography.

Heart Surg Forum 2019 Mar 8;22(2):E112-E118. Epub 2019 Mar 8.

Children's Heart Center, People's Hospital of Zhengzhou University, Zhengzhou, China.

Background: Perimembranous ventricular septal defect (pmVSD) is a common congenital heart disease. Transaxillary occluder device closure of the pmVSD has been proved effective and an alternative to surgical closure. The study aimed to evaluate the immediate operation outcomes and the early and midterm follow-up outcomes of transaxillary occluder device closure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1532/hsf.2185DOI Listing

Immobilization of polyphosphoesters on poly(ether ether ketone) (PEEK) for facilitating mineral coating.

J Biomater Sci Polym Ed 2019 Apr 23:1-15. Epub 2019 Apr 23.

a Department of Chemistry and Materials Engineering; Faculty of Chemistry, Materials and Bioengineering , Kansai University , 3-3-35 Yamate-cho , Suita-shi , Osaka 564-8680 , Japan.

Poly(ether ether ketone) (PEEK) is an alternative material to metals for orthopedic applications. However, the compatibility of PEEK with hard tissues needs to be improved. To address this issue, this study proposes a novel technique for PEEK surface modifications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09205063.2019.1595305DOI Listing

Prediction of orthosteric and allosteric regulations on cannabinoid receptors using supervised machine learning classifiers.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Designing highly selective compounds to protein subtypes, and developing allosteric modulators targeting them are critical considerations to both drug discovery and mechanism studies for cannabinoid receptors. It is challenging but in demand to have classifiers to identify active ligands from inactive or random compounds, and distinguish allosteric modulators from orthosteric ligands. In this study, supervised machine learning classifiers were built for two subtypes of cannabinoid receptors, CB1 and CB2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00182DOI Listing

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences , Nanjing University , Nanjing 210023 , P.R. China.

Cancer is characterized by abnormal cellular energy metabolism, which preferentially switches to aerobic glycolysis rather than oxidative phosphorylation as a means of glucose metabolism. Many key enzymes involved in the abnormal glycolysis are potential targets of anticancer drugs. Platinum(IV) complexes are potential anticancer prodrugs and kinetically more inert than the platinum(II) counterparts, which offer an opportunity to be modified by functional ligands for activation or targeted delivery. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.inorgchem.9b00708
Publisher Site
http://dx.doi.org/10.1021/acs.inorgchem.9b00708DOI Listing
April 2019
1 Read

A comparative study on the effectiveness of herbal extracts vs 2.5% benzoyl peroxide in the treatment of mild to moderate acne vulgaris.

J Cosmet Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Skin Center, Srinakharinwirot University, Bangkok, Thailand.

Background: Although there is a standard guideline for the treatment of acne, it is still a common skin disease, and suboptimal medication adherence is a major reason for treatment failure. Herbal extracts are an interesting alternative medicine because they consist of a variety of active ingredients. Moreover, herbal extracts may have improved therapeutic efficacy because of the combination of various herbs. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12962
Publisher Site
http://dx.doi.org/10.1111/jocd.12962DOI Listing
April 2019
1 Read

Subcritical Fluid Extraction of Antioxidant Phenolic Compounds from Pistachio (Pistacia vera L.) Nuts: Experiments, Modeling, and Optimization.

J Food Sci 2019 Apr 23. Epub 2019 Apr 23.

Facultad de Ciencias Exactas, Físicas y Naturales (UNC), Inst. Multidisciplinario de Biología Vegetal (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Univ. Nacional de Córdoba (UNC), Av. Vélez Sarsfield 1611, Córdoba, Argentina.

A process to obtain phenolic compounds with antioxidant properties from pistachio nuts using water/ethanol mixture under high temperature and pressure conditions was carried out. To optimize extraction conditions and antioxidant activity of bioactive compounds, theoretical models were scanned against experimental data. Phenolic profile was dominated by several flavonoids and gallic acid derivatives. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1750-3841.14507DOI Listing

Narrow pollen diets are associated with declining Midwestern bumble bee species.

Ecology 2019 Apr 23:e02697. Epub 2019 Apr 23.

Department of Entomology, Michigan State University, East Lansing, Michigan, 48824, USA.

Many species of bumble bee (Bombus) have declined in range and abundance across Europe, the Americas, and Asia, whereas other species have persisted and remain common and widespread. One explanation as to why some species have declined, based primarily on studies of the European bumble bee fauna, is that declining species have relatively narrow pollen-foraging niches and are less able to use alternative host plants in the absence of their preferred hosts. Though extensively explored in Europe, this hypothesis has not been investigated in North America, in part due to incomplete information on the foraging niche of many species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ecy.2697DOI Listing

Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, and potentially morbid, disease that affects one-third of the U.S. population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.127737DOI Listing

Diabetes and Outcomes following Guided De-Escalation of Antiplatelet Treatment in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: A Prespecified Analysis from the Randomized TROPICAL-ACS Trial.

EuroIntervention 2019 Apr 23. Epub 2019 Apr 23.

Ludwig-Maximilians University, Department of Cardiology, Munich, Germany.

Aims: A guided de-escalation of P2Y12 inhibitor treatment is considered as an alternative treatment strategy in ACS patients undergoing PCI. However, the safety and efficacy of this strategy may differ in diabetic vs. non-diabetic patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4244/EIJ-D-18-01077DOI Listing

Long term control and preservation of renal function after multiple courses of stereotactic body radiation therapy for renal cell carcinoma.

Can J Urol 2019 Apr;26(2):9743-9745

Transitional Year Program, Riverside Regional Medical Center, Newport News, Virginia, USA.

Renal cell carcinoma (RCC) is usually treated with surgery, with or without systemic therapy. For select patients, stereotactic body radiation therapy (SBRT) may be a suitable alternative. Although many reports exist on the successful use of SBRT, very few have described long term outcomes with regard to disease progression and renal function. Read More

View Article

Download full-text PDF

Source

Outcomes of upper tract urothelial cancer managed non-surgically.

Can J Urol 2019 Apr;26(2):9699-9707

Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA.

Introduction: Approximately 7% of patients with localized upper tract urothelial cancer (UTUC) are treated without definitive therapy. Understanding outcomes and alternative therapy would aid in counseling older patients with comorbidities.

Materials And Methods: We utilized the National Cancer Database to identify patients with localized UTUC managed non-surgically between 2004 and 2013. Read More

View Article

Download full-text PDF

Source

LittlEARS auditory questionnaire as an infant hearing screening in Germany after the newborn hearing screening.

Int J Audiol 2019 Apr 23:1-8. Epub 2019 Apr 23.

c German Pediatrician Association (Berufsverband der Kinder- und Jugendärzte BVKJ) , Cologne , Germany.

Objective: To investigate the feasibility of using the LittlEARS® Auditory Questionnaire (LEAQ®) as part of the infant hearing screening programme in Germany.

Design: LEAQ®s were distributed to 47 paediatric practices and were completed by the parents/guardians of the infants (aged between 9-14 months) involved in the study (= LEAQ screening). The infants who failed the LEAQ screening were invited to a LEAQ rescreening. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14992027.2019.1
Publisher Site
http://dx.doi.org/10.1080/14992027.2019.1597287DOI Listing
April 2019
1 Read

Recent perspectives on the virulent factors and treatment options for multidrug-resistant Acinetobacter baumannii.

Crit Rev Microbiol 2019 Apr 23:1-19. Epub 2019 Apr 23.

a Department of Biotechnology , Dayananda Sagar College of Engineering , Bangalore , India.

Acinetobacter baumannii (AB) is one of the most notorious and opportunistic pathogens, which caused high morbidity and mortality rate and World Health Organization (WHO) declared this bacterium as priority-1 pathogen in 2017. The current antibacterial agents, such as colistins, carbapenems, and tigecyclines have limited applications, which necessitate novel and alternative therapeutic remedies. Thus, the understanding of recent perspectives on the virulent factors and antibiotic resistance mechanism exhibited by the bacteria are extremely important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1040841X.2019.1600472DOI Listing

The Forest and the Trees: Investigating the Globality and Specificity of Employees' Basic Need Satisfaction at Work.

J Pers Assess 2019 Apr 23:1-12. Epub 2019 Apr 23.

a Université de Tours, QualiPsy EE 1901, Tours , France.

This research assessed the underlying psychometric multidimensionality and nomological validity of 523 employees' responses to the Work-related Basic Need Satisfaction (W-BNS) scale using bifactor-exploratory structural equation modeling (bifactor-ESEM). Our results first showed the superiority of a bifactor-ESEM representation when compared to alternative representations of the data. Thus, employees' ratings of psychological need satisfaction simultaneously reflected a global need satisfaction construct, which coexisted with specific autonomy, competence, and relatedness needs satisfaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00223891.2019.1591426DOI Listing

The language and communication attributes of graphic symbol communication aids - a systematic review and narrative synthesis.

Disabil Rehabil Assist Technol 2019 Apr 23:1-11. Epub 2019 Apr 23.

a Faculty of Health, Psychology and Social Care , Manchester Metropolitan University , Manchester , UK.

Background: Symbol communication aids are used by children with little or no intelligible speech as an Augmentative and Alternative Communication strategy. Graphic symbols are used to help support understanding of language and used in symbol communication aids to support expressive communication. The decision making related to the selection of a symbol communication aid for a child is poorly understood and little is known about what language and communication attributes are considered in this selection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17483107.2019.1604828DOI Listing

The process of 3D printed skull models for anatomy education.

Comput Assist Surg (Abingdon) 2019 Apr 23:1-10. Epub 2019 Apr 23.

i Department of Endocrinology, Endocrine Key Laboratory of Ministry of Health , PUMCH, CAMS & PUMC , Beijing , China.

In general, the 3 D printed medical models are made based on virtual digital models obtained from machines such as the computed tomography scanner. However, due to the limited accuracy of CT scanning technology, which is usually 1 millimeter, there are differences between scanned results and the real structure. Besides, the collected data can hardly be printed directly because of some errors in the model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/24699322.2018.1560101DOI Listing

Parameterized Analysis of Multi-objective Evolutionary Algorithms and the Weighted Vertex Cover Problem.

Evol Comput 2019 Apr 23:1-17. Epub 2019 Apr 23.

Optimisation and Logistics, The University of Adelaide, Adelaide, SA 5005, Australia

Evolutionary multi-objective optimization for the classical vertex cover problem has been analysed in [12] in the context of parameterized complexity analysis. This paper extends the analysis to the weighted vertex cover problem in which integer weights are assigned to the vertices and the goal is to find a vertex cover of minimum weight. Using an alternative mutation operator introduced in [12], we provide a fixed parameter evolutionary algorithm with respect to , the cost of an optimal solution for the problem. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1162/evco_a_00255DOI Listing

Parametrizing Theories of Gravity on Large and Small Scales in Cosmology.

Phys Rev Lett 2019 Jan;122(1):011301

School of Mathematics & Statistics, Dalhousie University, Halifax NS B3H 4R2, Canada.

We present a link between parametrizations of alternative theories of gravity on large and small scales in cosmology. This relationship is established using theoretical consistency conditions only. We find that in both limits the "slip" and "effective Newton's constant" can be written in terms of a set of four functions of time, two of which are direct generalizations of the α and γ parameters from post-Newtonian physics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1103/PhysRevLett.122.011301DOI Listing
January 2019

Quasimonoenergetic Proton Bunch Acceleration Driven by Hemispherically Converging Collisionless Shock in a Hydrogen Cluster Coupled with Relativistically Induced Transparency.

Phys Rev Lett 2019 Jan;122(1):014804

Graduate School of Energy Science, Kyoto University, Gokasho, Uji, Kyoto 611-0011, Japan.

An approach for accelerating a quasimonoenergetic proton bunch via a hemispherically converging collisionless shock created in laser-cluster interactions at the relativistically induced transparency (RIT) regime is studied using three-dimensional particle-in-cell simulations. By the action of focusing a petawatt class laser pulse onto a micron-size spherical hydrogen cluster, a crescent-shaped collisionless shock is launched at the laser-irradiated hemisphere and propagates inward. The shock converges at the sphere center in concurrence with the onset of the RIT, thereby allowing the proton bunch to be pushed out from the shock surface in the laser propagation direction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1103/PhysRevLett.122.014804DOI Listing
January 2019

α-AgVO Decorated by Hydroxyapatite (Ca(PO)(OH)): Tuning Its Photoluminescence Emissions and Bactericidal Activity.

Inorg Chem 2019 Apr 23. Epub 2019 Apr 23.

Departamento de Química , CDMF, Universidade Federal de São Carlos (UFSCar) , 13565-905 São Carlos , São Paulo , Brazil.

Defect-related luminescent materials have attracted interest because of their excellent optical properties and are considered as a less expensive and nontoxic alternative to commonly used lanthanide-based optical systems. These materials are fundamentally and technologically important for the next generation of full-color tunable light-emitting diodes as well as in the biomedical field. In this study, we report the preparation of α-silver vanadate (α-AgVO, AV) decorated by hydroxyapatite (Ca(PO)(OH), HA) with intense photoluminescence (PL) emissions at various HA/AV molar ratios (1:1-1:1/32) by a simple route based on chemical precipitation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.inorgchem.9b00249DOI Listing

Greenhouse Gas Emissions in the United States Food System: Current and Healthy Diet Scenarios.

Environ Sci Technol 2019 Apr 23. Epub 2019 Apr 23.

Friedman School of Nutrition Science and Policy , Tufts University , Boston , Massachusetts 02111 , United States.

We estimate the impact on greenhouse gas emissions (GHGE) of shifting from the current average United States diet to four alternative diets that meet the 2010 Dietary Guidelines for Americans (DGA). In contrast to prior studies, which rely on process-based life-cycle-analysis GHGE estimates from the literature for particular food items, we combine a diet model, an environmentally extended input-output model of energy use in the U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.est.8b06828DOI Listing

Substitution of an Internal Disulfide Bridge in Human Insulin by a Diselenide Enhances its Foldability and Stability.

Chemistry 2019 Apr 23. Epub 2019 Apr 23.

The Hebrew University of Jerusalem, Institute of Chemistry, Edmond J. Safra Campus, Givat Ram, 91904, Jerusalem, ISRAEL.

Insulin analogs exemplify the utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the individual A and B chains were accomplished in the early 1960s, their combination to form native insulin remains inefficient due to competing disulfide pairing and aggregation. To overcome these limitations, we envisioned an alternative approach: pairwise substitution of cysteine residues by selenocysteine (Sec, U). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201900892DOI Listing

Long-term in vitro treatment with telomerase inhibitor MST-312 induces resistance by selecting long telomeres cells.

Cell Biochem Funct 2019 Apr 23. Epub 2019 Apr 23.

Multidisciplinary Laboratory of Human Health, University of Brasilia, Brasília, Brazil.

Telomerase is a good target for new anticancer drug development because it is present in over 85% of human tumours. However, despite chronic therapy is a condition for anti-telomerase approach, the effects of long-term treatment with telomerase inhibitors remain not well understood. In this work, it was evaluated the effects of long-term treatment of human MDA-MB-231 breast cancer cells with the telomerase inhibitor MST-312. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbf.3398DOI Listing

Investigation of the position of the radical in z-ions resulting from electron transfer dissociation using infrared ion spectroscopy.

Faraday Discuss 2019 Apr 23. Epub 2019 Apr 23.

Radboud University, FELIX Laboratory, Toernooiveld 7, 6525 ED Nijmegen, The Netherlands and Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.

The molecular structures of six open-shell z3-ions resulting from electron transfer dissociation mass spectrometry (ETD MS) were investigated using infrared ion spectroscopy in the 800-1850 and 3200-3700 cm-1 spectral ranges in combination with density functional theory and molecular mechanics/molecular dynamics calculations. We assess in particular the question of whether the radical remains at the Cα-site of the backbone cleavage, or whether it migrates by H-atom transfer to another, energetically more favorable position. Calculations performed herein as well as by others show that radical migration to an amino acid side chain or to an α-carbon along the peptide backbone can lead to structures that are more stable, by up to 33 kJ mol-1 for the systems investigated here, by virtue of resonance stabilization of the radical in these alternative positions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8fd00202aDOI Listing

Refinement of the Child Amblyopia Treatment Questionnaire (CAT-QoL) using Rasch analysis.

Authors:
Jill Carlton

Strabismus 2019 Apr 23:1-12. Epub 2019 Apr 23.

a School of Health and Related Research, HEDS, ScHARR , University of Sheffield , Sheffield.

Aims or Purpose: The Child Amblyopia Treatment Questionnaire (CAT-QoL) was developed using a "bottom-up" methodological approach. Interviews with children with amblyopia identified items (questions) and response levels to be tested in a draft questionnaire consisting of 11 items (sad, feeling on face, hurt, doing schoolwork, cross, how other children treat you, doing things, worried, upset with family, playing with friends, happy). This study describes the refinement of the descriptive system for the CAT-QoL instrument using the application of Rasch analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09273972.2019.1601743DOI Listing

Recent Advances on Electrochemical Sensors for the Detection of Organic Disinfection Byproducts in Water.

ACS Sens 2019 Apr 23. Epub 2019 Apr 23.

College of Engineering , Swansea University , Bay Campus, Swansea SA1 8EN , United Kingdom.

Irreversible organ damage or even death frequently occurs when humans or animals unknowingly drink contaminated water. Therefore, in many countries drinking water is disinfected to ensure removal of harmful pathogens from drinking water. If upstream water treatment prior to disinfection is not adequate, disinfection byproducts (DBPs) can be formed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acssensors.9b00272DOI Listing

Corneal cross-linking (CXL)-A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses.

Vet Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.

Objective: Compare CXL treatment with medical treatment alone in horses with stromal, ulcerative keratitis.

Animals Studied: 24 horses (24 eyes) with stromal, ulcerative keratitis were included.

Procedure: 12 horses were initially treated with CXL, and 12 horses were given conventional medical treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vop.12662DOI Listing

Home-based exergaming was safe and significantly improved 6-min walking distance in prostate cancer patients: a single-blinded randomized controlled trial.

BJU Int 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

Objectives: To explore the effects of 12 weeks of unsupervised home-based exergaming (i.e. technology-driven exercise) compared to usual care on physical function, body composition, quality of life (QoL) and fatigue in prostate cancer patients (PCa) on androgen deprivation therapy (ADT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14782DOI Listing

The effect of local aspiration and methotrexate injection on live interstitial pregnancy coexisting with live intrauterine pregnancy after assisted reproductive technology.

J Obstet Gynaecol Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Aim: To share the experience of local aspiration and instillation of methotrexate (MTX) to selective reduction of live interstitial pregnancy and to evaluate its clinical effect and the outcome of intrauterine pregnancy.

Methods: Twelve patients with heterotopic interstitial pregnancy were enrolled at Women's Hospital, Zhejiang University School of Medicine, from 2006 to 2017. All the pregnancies were derived from assisted reproductive technology (ART). Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jog.13975
Publisher Site
http://dx.doi.org/10.1111/jog.13975DOI Listing
April 2019
1 Read

Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes.

J Biomed Mater Res A 2019 Apr 22. Epub 2019 Apr 22.

Department of Ophthalmology, RWTH Aachen University Hospital, Aachen, Germany.

Corneal transplantation is the treatment of choice for patients with advanced corneal diseases. However, the outcome may be affected by graft rejection, high associated costs, surgical expertise and most importantly the worldwide donor shortage. In recent years, bioprinting has emerged as an alternative method for fabricating tissue equivalents using autologous cells with architecture resembling the native tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36702DOI Listing

Rapid eye movement sleep deprivation enhances vulnerability of striatal dopaminergic neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice.

Psychogeriatrics 2019 Apr 22. Epub 2019 Apr 22.

Department of Perioperative Management System, Nagoya University Graduate School of Medicine, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/psyg.12456DOI Listing

Inorganic and Layered Perovskites for Optoelectronic Devices.

Adv Mater 2019 Apr 23:e1807095. Epub 2019 Apr 23.

Department of Physics, University of Konstanz, 78457, Konstanz, Germany.

Organic-inorganic halide perovskites are making breakthroughs in a range of optoelectronic devices. Reports of >23% certified power conversion efficiency in photovoltaic devices, external quantum efficiency >21% in light-emitting diodes (LEDs), continuous-wave lasing and ultralow lasing thresholds in optically pumped lasers, and detectivity in photodetectors on a par with commercial GaAs rivals are being witnessed, making them the fastest ever emerging material technology. Still, questions on their toxicity and long-term stability raise concerns toward their market entry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201807095DOI Listing

Using contingent valuation to develop consumer-based weights for health quality report cards.

Health Serv Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Medicine, Division of General Internal Medicine, iTEQC Research Program, University of California, Irvine, California.

Objective: The current 5-Star composite measure for nursing homes uses expert-driven weights to combine elements of quality into a single score. We assessed the feasibility of using the contingent valuation method (CVM) to derive consumers' preference-based weights for the Nursing Home Compare report card as a potential alternative approach.

Data Sources: Survey of 4310 adults with nursing home experience (residents or family members of a resident) administered between September 25 and October 9, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1475-6773.13155DOI Listing

Complementary and Integrated Health Approaches: What Do Veterans Use and Want.

J Gen Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Integrative Health Coordinating Center, VA Office of Patient Centered Care and Cultural Transformation, Los Angeles, CA, USA.

Objectives: Non-pharmacological treatment options for common conditions such as chronic pain, anxiety, and depression are being given increased consideration in healthcare, especially given the recent emphasis to address the opioid crisis. One set of non-pharmacological treatment options are evidence-based complementary and integrative health (CIH) approaches, such as yoga, acupuncture, and meditation. The Veterans Health Administration (VHA), the nation's largest healthcare system, has been at the forefront of implementing CIH approaches, given their patients' high prevalence of pain, anxiety, and depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11606-019-04862-6DOI Listing

Management of Thrombocytopenia in Patients with Chronic Liver Disease.

Dig Dis Sci 2019 Apr 22. Epub 2019 Apr 22.

Weill Cornell Medical College, New York, NY, USA.

Background: Thrombocytopenia is the most common hematologic complication associated with chronic liver disease (CLD) with important clinical implications. While the mechanisms for thrombocytopenia are multifactorial, platelet sequestration in the spleen and decreased thrombopoietin (TPO) production are the main mechanisms in patients with CLD.

Aim: This review outlines the current treatment options for thrombocytopenia in patients with CLD, explores their limitations, and proposes a revised treatment algorithm for the management of thrombocytopenia in this patient group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05615-5DOI Listing

Educator as Diagnostician, Judge and Confidant: a positioning analysis of medical student support encounters.

Adv Health Sci Educ Theory Pract 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Education, Melbourne Medical School, University of Melbourne, Parkville, VIC, 3052, Australia.

Medical schools, programs and educators are increasingly expected to address medical student stress and wellbeing, yet also ensure student competence and fitness to practice. Educators play a central role in supporting students when evaluating a student's concerns and in deciding whether support and/or sanction should be offered. It is not known how educators approach or resolve such potentially contradictory responses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10459-019-09892-7DOI Listing

The security of radical trachelectomy in the treatment of IA-IIA cervical carcinoma requires further evaluation: updated meta-analysis and trial sequential analysis.

Arch Gynecol Obstet 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, North Road of Workers Stadium, Chaoyang District, Beijing, 100020, China.

Purpose: The aim of this study was to assess the security of radical trachelectomy (RT) in the treatment of IA-IIA cervical carcinoma and conducted a new survey based upon the results of previous researches.

Methods: The PMC, PubMed, Web of Science, Cochrane and EMBASE databases were retrieved to collect prospective clinical controlled trials (CCTs) published from 1984 to 2018. The oncologic outcomes were evaluated by meta-analysis, trial sequence analysis (TSA) and statistical analysis. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00404-019-05141-9
Publisher Site
http://dx.doi.org/10.1007/s00404-019-05141-9DOI Listing
April 2019
1 Read

Fashioning enterotomy closure after totally laparoscopic ileocolic anastomosis for right colon cancer: a multicenter experience.

Surg Endosc 2019 Apr 22. Epub 2019 Apr 22.

Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Pansini 5, 80131, Naple, Italy.

Background: Laparoscopic right hemicolectomy is a commonly performed procedure. Little is known on how to perform the enterotomy closure after stapled side-to-side intracorporeal anastomosis.

Method: A multicentric case-controlled study has been designed to compare different ways to fashion enterotomy closure: double layer versus single layer, sewn versus stapled, and robotic versus laparoscopic approach. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-019-06796-wDOI Listing

Recent advances in the biocontrol of Xanthomonas spp.

World J Microbiol Biotechnol 2019 Apr 22;35(5):72. Epub 2019 Apr 22.

Department of Biochemistry and Microbiology, Institute of Biosciences, São Paulo State University (UNESP) "Júlio de Mesquita Filho", Rio Claro, São Paulo, Brazil.

Bacterial diseases caused by members of the genus Xanthomonas affect agricultural crops of great importance in the world. At least 350 different plant diseases are caused by species of Xanthomonas. Important crops, such as: rice, citrus, cassava, tomato, sugar cane, passionfruit and brassicas are severely affected by bacteria of this genus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11274-019-2646-5DOI Listing

Reduced Elective Operation Rates and High Patient Satisfaction After the Implementation of Decision Aids in Patients with Gallstones or an Inguinal Hernia.

World J Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Background: For both gallbladder removal and inguinal hernia repair, it is important to include patients' perspective in the decision-making process, as watchful waiting is an accepted alternative in selected patients. The aim of this study was to evaluate operation rates before and after implementation of decision aids (DAs) and to assess patient compliance with the use of DAs.

Methods: A single-centered retrospective study was performed, including all patients ≥18 years referred to the surgical outpatient clinic with symptomatic gallstones or an inguinal hernia between January 2014 and December 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-019-05007-wDOI Listing