527,003 results match your criteria Alternative medicine review : a journal of clinical therapeutic[Journal]


ERCP with overtube-assisted enteroscopy in patients with Roux-en-Y gastric bypass anatomy: a systematic review and meta-analysis.

Endoscopy 2020 Jun 3. Epub 2020 Jun 3.

Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, United States.

Background:  Endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastric bypass (RYGB) anatomy is challenging. Overtube-assisted enteroscopy (OAE) is usually needed to perform ERCP in these patients. There is significant variation in the reported rates of success and adverse events across published studies. Read More

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http://dx.doi.org/10.1055/a-1178-9741DOI Listing

Transcranial Sonography Findings in Alzheimer's Disease: A New Imaging Biomarker.

Ultraschall Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

Objective:  To validate transcranial sonography (TCS) as a novel imaging tool for the assessment of medial temporal lobe (MTL) atrophy (MTA).

Materials And Methods:  Participants with Alzheimer's disease (AD, n = 30) and age-sex-matched controls (n = 30) underwent TCS and MRI. On TCS, MTL structures (choroidal fissure (CF) and temporal horn (TH)) were measured and combined to create an MTA score in sonography (MTA-S). Read More

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http://dx.doi.org/10.1055/a-1146-3036DOI Listing

The use of next generation sequencing for the quality control of live-attenuated polio vaccines.

J Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Division of Virology, National Institute for Biological Standards and Control (NIBSC), South Mimms, Potters Bar, Herts, UK.

Background: Next generation sequencing (NGS) analysis was compared to the current MAPREC (mutational analysis by PCR and restriction enzyme cleavage) assay for the quality control of live-attenuated oral polio vaccine (OPV).

Methods: MAPREC measures reversion of the main OPV attenuating mutations such as uracil (U) to cytosine (C) at nucleotide 472 in the 5' non-coding-region of type 3 OPV. Eleven type 3 OPV samples were analysed by eight laboratories using their in-house NGS method. Read More

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http://dx.doi.org/10.1093/infdis/jiaa299DOI Listing

Hydrothermally grown ZnO nanowire array as an oxygen vacancies reservoir for improved resistive switching.

Nanotechnology 2020 Jun 3. Epub 2020 Jun 3.

Applied Science and Technology, Politecnico di Torino, C so Duca degli Abruzzi 24, 10129 Torino, Torino, ITALY.

Resistive switching (RS) devices based on self-assembled nanowires (NWs) and nanorods (NRs) represent a fascinating alternative to conventional devices with thin film structure. The high surface-to-volume ratio may indeed provide the possibility of modulating their functionalities through surface effects. However, devices based on NWs usually suffer from low resistive switching performances in terms of operating voltages, endurance and retention capabilities. Read More

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http://dx.doi.org/10.1088/1361-6528/ab9920DOI Listing

Optimizing neuromodulation based on surrogate neural states for seizure suppression in a rat temporal lobe epilepsy model.

J Neural Eng 2020 Jun 3. Epub 2020 Jun 3.

Neurosurgery, Emory University, Atlanta, Georgia, UNITED STATES.

Objective: Developing a new neuromodulation method for epilepsy treatment requires a large amount of time and resources to find effective stimulation parameters and often fails due to inter-subject variability in stimulation effect. As an alternative, we present a novel data-driven surrogate approach which can optimize the neuromodulation efficiently by investigating the stimulation effect on surrogate neural states.

Approach: Medial septum (MS) optogenetic stimulation was applied for modulating electrophysiological activities of the hippocampus in a rat temporal lobe epilepsy model. Read More

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http://dx.doi.org/10.1088/1741-2552/ab9909DOI Listing

Differential impact of Holder and High Temperature Short Time pasteurization on the dynamic in vitro digestion of human milk in a preterm newborn model.

Food Chem 2020 May 25;328:127126. Epub 2020 May 25.

STLO, INRAE, Institut Agro, 35042, Rennes, France. Electronic address:

The high-temperature short-time (HTST, 72 °C, 15 s) pasteurization of human milk (HM) has been proposed as an alternative to the Holder method (HoP, 62.5 °C, 30 min), to increase the preservation of bioactive compounds. We have investigated the impact of HTST and HoP pasteurization on the gastrointestinal kinetics of human milk, using a dynamic in vitro system in a preterm newborn model. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127126DOI Listing

Clinical use of vascular endothelial growth factor receptor inhibitors for the treatment of renal cell carcinoma.

Eur J Med Chem 2020 May 22;200:112482. Epub 2020 May 22.

Faculty of Life Science and Technology, Kunming University of Science and Technology, PR China. Electronic address:

In recent years, there have been increased incidences of metastatic renal cell carcinoma (RCC), which is refractory to conventional chemotherapy. Owing to the insensitivity to traditional therapy, targeted therapy becomes a possible alternative strategy. Over the past decade, the development of targeted treatments for metastatic RCC has advanced considerably. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112482DOI Listing

Structural extracellular polymeric substances determine the difference in digestibility between waste activated sludge and aerobic granules.

Water Res 2020 May 16;181:115924. Epub 2020 May 16.

Section Sanitary Engineering, Department of Water Management, Faculty of Civil Engineering and Geosciences, Delft University of Technology, Stevinweg 1, 2628, CN, Delft, the Netherlands.

Aerobic granular sludge (AGS) technology is an alternative to conventional activated sludge to reduce the process footprint and energy consumption. Strategies for the efficient management of its produced biomass, that is grown in a granular morphology as well, need further development. Anaerobic digestion (AD) is commonly applied in waste activated sludge (WAS) treatment and is a potential option also for produced AGS treatment. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115924DOI Listing

Application of purple phototrophic bacteria in a biofilm photobioreactor for single cell protein production: Biofilm vs suspended growth.

Water Res 2020 May 18;181:115909. Epub 2020 May 18.

Advanced Water Management Centre, The University of Queensland, Gehrmann Building, Brisbane, Queensland, 4072, Australia.

Single cell protein (SCP), has been proposed as alternative to effectively upgrade and recycle organics and nutrients from wastewater. Biomass recovery is a critical issue, and recovery as a biofilm is effective in comparison with sedimentation of suspended biomass. This study aims to determine the applicability of purple phototrophic bacteria (PPB) biofilm on infra-red irradiated, submerged surfaces for the treatment of pre-settled red meat processing wastewater, and SCP generation. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115909DOI Listing

High-dimensional embedding network derived prior for compressive sensing MRI reconstruction.

Med Image Anal 2020 May 21;64:101717. Epub 2020 May 21.

Department of Electronic Information Engineering, Nanchang University, Nanchang 330031, China. Electronic address:

Although recent deep learning methodology has shown promising performance in fast imaging, the network needs to be retrained for specific sampling patterns and ratios. Therefore, how to explore the network as a general prior and leverage it into the observation constraint flexibly is urgent. In this work, we present a multi-channel enhanced Deep Mean-Shift Prior (MEDMSP) to address the highly under-sampled magnetic resonance imaging reconstruction problem. Read More

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http://dx.doi.org/10.1016/j.media.2020.101717DOI Listing

Modified Full-Endoscopic Interlaminar Discectomy via an Inferior Endplate Approach for Lumbar Disc Herniation: Retrospective 3-Year Results from 321 Patients.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Department of Spine surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China. Electronic address:

Background: Percutaneous endoscopic interlaminar discectomy (PEID) is widely used as a minimally invasive procedure that shows satisfying outcomes for the treatment of L5/S1 and even L4/5 disc herniation. PEID can be divided into direct and indirect approaches according to the established method of the working channel. The direct approach mainly utilizes the puncture needle directly through the intervertebral space into the intervertebral disc under non-direct vision and insertion of the guidewire into the puncture needle to guide the dilator and working channel to retract the ligamentum flavum, dural sac and nerve roots. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.234DOI Listing

Fast SARS-CoV-2 detection by RT-qPCR in preheated nasopharyngeal swab samples.

Int J Infect Dis 2020 May 31. Epub 2020 May 31.

Genomics Division, Instituto Tecnológico y de Energías Renovables, 38600 Santa Cruz de Tenerife, Spain; Research Unit, Hospital Universitario N. S. de Candelaria, 38010 Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, 28029 Madrid, Spain; Instituto de Tecnologías Biomédicas (ITB) Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain. Electronic address:

Objectives: The gold-standard COVID-19 diagnosis relies on detecting SARS-CoV-2 using RNA purification and one-step retrotranscription and quantitative PCR (RT-qPCR). Based on the urgent need for high-throughput screening, we tested the performance of three alternative, simple and affordable protocols to rapidly detect SARS-CoV-2, bypassing the long and tedious RNA extraction step and reducing the time to viral detection.

Methods: We evaluated three methods based on direct nasopharyngeal swab viral transmission medium (VTM) heating before the RT-qPCR: a) direct without additives; b) in a formamide-EDTA (FAE) buffer, c) in a RNAsnap buffer. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.099DOI Listing

The antimicrobial peptide tilapia piscidin 3 induces mitochondria-modulated intrinsic apoptosis of osteosarcoma cells.

Biochem Pharmacol 2020 May 31:114064. Epub 2020 May 31.

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan; Center for Neuroscience, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan. Electronic address:

Osteosarcoma (OS) is the most common solid tumor of the bone that most often affects adolescents. The introduction of chemotherapy for the treatment of OS has largely improved the survival rates of patients with localized tumors. However, the 5-year survival rate of OS patients with relapsed or metastatic disease is only 10 to 20%. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114064DOI Listing

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.

Cell Rep 2020 Jun;31(9):107703

Fondazione Santa Lucia, IRCCS, Rome, Italy; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy. Electronic address:

Tight coordination of gene expression in the developing cerebellum is crucial for establishment of neuronal circuits governing motor and cognitive function. However, transcriptional changes alone do not explain all of the switches underlying neuronal differentiation. Here we unveiled a widespread and highly dynamic splicing program that affects synaptic genes in cerebellar neurons. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107703DOI Listing

Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening.

Cell 2020 May 29. Epub 2020 May 29.

Department of Neuroscience and Physiology, Neuroscience Institute, NYU Grossman Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address:

Homeostasis of neural firing properties is important in stabilizing neuronal circuitry, but how such plasticity might depend on alternative splicing is not known. Here we report that chronic inactivity homeostatically increases action potential duration by changing alternative splicing of BK channels; this requires nuclear export of the splicing factor Nova-2. Inactivity and Nova-2 relocation were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mechanisms akin to Hebbian plasticity: Ca-permeable AMPA receptor upregulation, L-type Ca channel activation, enhanced spine Ca transients, nuclear translocation of a CaM shuttle, and nuclear CaMKIV activation. Read More

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http://dx.doi.org/10.1016/j.cell.2020.05.013DOI Listing

Evaluation of boric acid as toxic sugar bait against resistant Aedes aegypti mosquitoes.

J Vector Ecol 2020 Jun;45(1):100-103

Anastasia Mosquito Control District, 120 EOC Drive, St. Augustine, FL, U.S.A.

Current methods of broad area application of contact insecticides used in mosquito control are becoming less effective, primarily due to resistance within mosquito populations. New methods that can deliver ingestible insecticides are being investigated as a means to mitigate resistance. This study evaluated insecticide delivery through toxic sugar baits (TSB) and resulting mortality of susceptible and resistant strains of Aedes aegypti. Read More

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http://dx.doi.org/10.1111/jvec.12377DOI Listing

Skin irritation potential of cosmetic preservatives: An exposure-relevant study.

J Cosmet Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Department of Cosmetics, School of Science, Beijing Technology and Business University, Beijing, China.

Background: Preservatives represent one of the main causes of skin irritation and contact allergies.

Aims: To comprehensively evaluate the skin irritation potential of phenoxyethanol, methylparaben, propylparaben, imidazolidinyl urea, and DMDM hydantoin under regulatory acceptable concentrations.

Methods: A patch test and repeated open application test (ROAT) were applied to evaluate skin irritation in vivo. Read More

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http://dx.doi.org/10.1111/jocd.13502DOI Listing

Evaluation of two lipid removal methods for stable carbon and nitrogen isotope analysis in whale tissue.

Rapid Commun Mass Spectrom 2020 Jun 3. Epub 2020 Jun 3.

Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, USA.

Rationale: The presence of lipids in animal tissues can influence the interpretation of stable isotope data, particularly in lipid-rich tissues such as the skin and muscle of marine mammals. The traditionally employed chloroform:methanol delipidation protocol has the potential to alter δ N values in proteinaceous tissues. Our objective was to determine whether cyclohexane is an alternative extraction method, effectively removing lipids without altering δ N values. Read More

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http://dx.doi.org/10.1002/rcm.8851DOI Listing

Supraclavicular Artery Island Flap: Critical Appraisal and Comparison to Alternate Reconstruction.

Laryngoscope 2020 Jun 3. Epub 2020 Jun 3.

USC Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, California, U.S.A.

Objectives/hypothesis: The supraclavicular artery island (SAI) flap may be a good option for selected head and neck reconstruction due to its reliability, ease of harvest, and favorable color match. The objective of this study was to examine the rates of complications for the SAI flap in head and neck oncologic reconstruction, with examination of risk factors and comparisons to alternative flaps often considered the gold-standard soft-tissue flaps for head and neck reconstruction: the pectoralis myocutaneous (PMC), radial forearm free flap (RFFF), and anterolateral thigh (ALT) flaps.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.28706DOI Listing

Cladribine modifies functional properties of microglia.

Clin Exp Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Background: Cladribine (CdA), an oral prodrug approved for the treatment of relapsing multiple sclerosis, selectively depletes lymphocytes. CdA passes the blood-brain barrier suggesting a potential effect on CNS resident cells.

Objective: We examined, if CdA modifies the phenotype and function of naïve and activated primary mouse microglia, when applied in the concentrations 0. Read More

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http://dx.doi.org/10.1111/cei.13473DOI Listing

Association of Specific Mental Disorders With Premature Mortality in the Danish Population Using Alternative Measurement Methods.

JAMA Netw Open 2020 Jun 1;3(6):e206646. Epub 2020 Jun 1.

National Centre for Register-Based Research, School of Business and Social Sciences, Aarhus University, Aarhus, Denmark.

Importance: The association of mental disorders with premature mortality published in the Global Burden of Disease (GBD) studies has been underestimated because these analyses have recommended using only a small number of mental disorders as causes of death to estimate years of life lost (YLL). Alternative methods have been introduced, such as estimating life-years lost (LYL), to compare individuals with mental disorders with the general population.

Objectives: To generate register-based YLL and LYL estimates and to use these measurement methods to assess the association of specific mental disorders with premature mortality. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.6646DOI Listing

Chlororespiration Serves as Photoprotection for Photo-Inactivated Oxygen-Evolving Complex in Zostera marina, a Marine Angiosperm.

Plant Cell Physiol 2020 Jun 3. Epub 2020 Jun 3.

Ocean School, Yantai University, Yantai, PR China.

As an alternative electron sink, chlororespiration, comprised of the NAD(P)H dehydrogenase complex and plastid terminal plastoquinone oxidase, may play a significant role for sustaining the redox equilibrium between stroma and thylakoid membrane. This study identified a distinct role of chlororespiration in the marine angiosperm Zostera marina, whose oxygen evolving complex (OEC) is prone to photo-inactivation as a result of its inherent susceptibility to excess irradiation. The strong connectivity between OEC peripheral proteins and key chlororespiratory enzymes, as demonstrated in the interaction network of differentially expressed genes, suggested that the recovery of photo-inactivated OEC was connected with chlororespiration. Read More

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http://dx.doi.org/10.1093/pcp/pcaa075DOI Listing

Flickering of cardiac state before the onset and termination of atrial fibrillation.

Chaos 2020 May;30(5):053137

National Heart Institute, 50400 Kuala Lumpur, Malaysia.

Complex dynamical systems can shift abruptly from a stable state to an alternative stable state at a tipping point. Before the critical transition, the system either slows down in its recovery rate or flickers between the basins of attraction of the alternative stable states. Whether the heart critically slows down or flickers before it transitions into and out of paroxysmal atrial fibrillation (PAF) is still an open question. Read More

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http://dx.doi.org/10.1063/1.5130524DOI Listing

Intraband Relaxation Dynamics of Charge Carriers within CdTe Quantum Wires.

J Phys Chem Lett 2020 Jun 3. Epub 2020 Jun 3.

The state-to-state intraband relaxation dynamics of charge carriers photogenerated within CdTe quantum wires (QWs) are characterized via transient absorption spectroscopy. Overlapping signals from the energetic-shifting of the quantum-confinement features and the occupancy of carriers in the states associated with these features are separated using the quantum-state renormalization model. Holes generated with an excitation energy of 2. Read More

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http://dx.doi.org/10.1021/acs.jpclett.0c01326DOI Listing

Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate.

J Am Chem Soc 2020 Jun 3. Epub 2020 Jun 3.

Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificity towards G4s remains a challenge and many ligands reported seemed to compromise between the two features. To cope with this challenge, we focused on targeting a particular type of G4s, i. Read More

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http://dx.doi.org/10.1021/jacs.0c00774DOI Listing

NiO/Poly(4-alkylthiazole)s Hybrid Interface for Promoting Spatial Charge Separation in Photoelectrochemical Water Reduction.

ACS Appl Mater Interfaces 2020 Jun 3. Epub 2020 Jun 3.

Conjugated polymers are emerging as alternatives to inorganic semiconductors for the photoelectrochemical (PEC) water splitting. Herein, semitransparent poly(4-alkylthiazole)s layers with different trialkylsilyloxymethyl (RSiOCH-) side-chains (PTzTNB: R = -butyl, PTzTHX: R = -hexyl) are applied to functionalize NiO thin films to build hybrid photocathodes. The hybrid interface allows the effective spatial separation of the photoexcited carriers. Read More

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http://dx.doi.org/10.1021/acsami.0c03975DOI Listing

Economic assessment of traditional surgical valve replacement versus use of transfemoral intervention in degenerative aortic stenosis.

Minerva Med 2020 Jun 2. Epub 2020 Jun 2.

Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria -

Objective: The aim of this study was to provide an economic assessment of interventional vs. surgical aortic valve replacement in the context of cost-effectiveness.

Background: Aortic stenosis represents the most common form of degenerative valvular heart diseases. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06640-9DOI Listing

Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation.

Phytother Res 2020 Jun 3. Epub 2020 Jun 3.

College of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Adverse effects that result from dexamethasone (DEX) use are common and serious in patients with asthma. Therefore, alternative anti-inflammatory treatments are being investigated. Isoimperatorin (ISO), an active natural furocoumarin, possesses multiple pharmacological properties, including an anti-inflammation effect. Read More

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http://dx.doi.org/10.1002/ptr.6726DOI Listing

Interactions of gene expression, alternative splicing, and DNA methylation in determining nodule identity.

Plant J 2020 Jun 3. Epub 2020 Jun 3.

Department of Plant Sciences, University of Tennessee, Knoxville, Tennessee, 37996, USA.

Soybean nodulation is a highly controlled process that involves complex gene regulation at both transcriptional and post-transcriptional levels. In this study, we profiled gene expression changes, alternative splicing events, and DNA methylation patterns during nodule formation, development and senescence. The transcriptome data uncovered key transcription patterns of nodule development that included 9,669 core genes and 7,302 stage-specific genes. Read More

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http://dx.doi.org/10.1111/tpj.14861DOI Listing

Elucidation of fungal dye-decolorizing peroxidase (DyP) and ligninolytic enzyme activities in decolorization and mineralization of azo dyes.

J Appl Microbiol 2020 Jun 3. Epub 2020 Jun 3.

Center for Biotechnology, School of Pharmaceutical Sciences, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, 751003, Odisha, India.

Aim: The aim of the study is to investigate the efficiency of Geotrichum candidum in the decolorization and mineralization of synthetic azo dyes.

Methods And Results: It includes screening of enzymes from G. candidum and its optimization, followed by decolorization and mineralization studies. Read More

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http://dx.doi.org/10.1111/jam.14731DOI Listing

Transorbital postcaruncular endoscopic surgery as an alternative to orbital exploratory surgery: A cadaveric study and case report in a dog with an orbital sarcoma.

Vet Surg 2020 Jun 3. Epub 2020 Jun 3.

Cornell University College of Veterinary Medicine, Ithaca, New York.

Objective: To describe a postcaruncular approach for transorbital endoscopy as an alternative, minimally invasive technique to access the orbital apex.

Study Design: Ex vivo and prospective clinical case report.

Animals: A 12-year-old male castrated cocker spaniel and three cadaver heads (one large breed dolichocephalic, one medium-sized breed mesocephalic, and one small breed brachycephalic). Read More

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http://dx.doi.org/10.1111/vsu.13446DOI Listing

Structural basis for the recognition of transiently structured AU-rich elements by Roquin.

Nucleic Acids Res 2020 Jun 3. Epub 2020 Jun 3.

Institute for Molecular Biosciences, Goethe University Frankfurt and Center for Biomolecular Magnetic Resonance (BMRZ), 60438 Frankfurt, Germany.

Adenylate/uridylate-rich elements (AREs) are the most common cis-regulatory elements in the 3'-untranslated region (UTR) of mRNAs, where they fine-tune turnover by mediating mRNA decay. They increase plasticity and efficacy of mRNA regulation and are recognized by several ARE-specific RNA-binding proteins (RBPs). Typically, AREs are short linear motifs with a high content of complementary A and U nucleotides and often occur in multiple copies. Read More

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http://dx.doi.org/10.1093/nar/gkaa465DOI Listing

Population specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians.

Hum Mol Genet 2020 Jun 3. Epub 2020 Jun 3.

Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Statistical imputation applied to genome-wide array data is the most cost-effective approach to complete the catalog of genetic variation in a study population. However, imputed genotypes in underrepresented populations incur greater inaccuracies due to ascertainment bias and a lack of representation among reference individuals, further contributing to the obstacles to study these populations. Here we examined the consequences due to the lack of representation by genotyping in a large number of self-reported Native Hawaiians (N = 3693) a functionally important, Polynesian-specific variant in the CREBRF gene, rs373863828. Read More

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http://dx.doi.org/10.1093/hmg/ddaa083DOI Listing

Comparative economic analysis of soil sampling methods used in precision agriculture.

An Acad Bras Cienc 2020 1;92 Suppl 1:e20190277. Epub 2020 Jun 1.

Departamento de Engenharia Agrícola, Universidade Federal de Lavras/UFLA, Lavras, MG, Brazil.

Precision agriculture is an alternative for reducing costs. This study evaluated and economically compared three sampling methods used in precision agriculture with respect to the acquisition of inputs and machines and equipment. The sampling methods used were zone management by elevation (ZME), grid sampling (GS) and sampling guided by apparent electrical conductivity of the soil (OS). Read More

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http://dx.doi.org/10.1590/0001-3765202020190277DOI Listing

Percutaneous Transseptal Bioprosthetic Implantation in Failed Prosthetic Surgical Mitral Valve - Brazilian Multicenter Experience.

Arq Bras Cardiol 2020 May 29. Epub 2020 May 29.

Hospital de Força Aérea do Galeão, Rio de Janeiro, RJ, Brasil.

Background Percutaneous intervention in patients with bioprosthetic mitral valve dysfunction is an alternative to conventional surgical treatment. Objectives To report the first Brazilian experience with transseptal transcatheter bioprosthetic mitral valve-in-valve implantation (transseptal-TMVIV). Methods Patients with surgical bioprosthetic dysfunction submitted to transseptal-TMVIV in 12 Brazilian hospitals were included. Read More

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http://dx.doi.org/10.36660/abc.20190252DOI Listing

Human fusariosis: An emerging infection that is difficult to treat.

Rev Soc Bras Med Trop 2020 1;53:e20200013. Epub 2020 Jun 1.

Programa de Pós-Graduação Stricto Sensu em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Fusarium spp. has been associated with a broad spectrum of emerging infections collectively termed fusariosis. This review includes articles published between 2005 and 2018 that describe the characteristics, clinical management, incidence, and emergence of these fungal infections. Read More

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http://dx.doi.org/10.1590/0037-8682-0013-2020DOI Listing

A historical review of the techniques of recovery of parasites for their detection in human stools.

Rev Soc Bras Med Trop 2020 1;53:e20190535. Epub 2020 Jun 1.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.

Since the early 20th century, the detection of intestinal parasites has improved with the development of several techniques for parasitic structures recovery and identification, which differ in sensitivity, specificity, practicality, cost, and infrastructure demand. This study aims to review, in chronological order, the stool examination techniques and discuss their advantages, limitations, and perspectives, and to provide professionals and specialists in this field with data that lays a foundation for critical analysis on the use of such procedures. The concentration procedures that constitute the main techniques applied in routine research and in parasitological kits are a) spontaneous sedimentation; b) centrifugation-sedimentation with formalin-ethyl acetate; and c) flotation with zinc sulfate solution. Read More

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http://dx.doi.org/10.1590/0037-8682-0535-2019DOI Listing

Cardiovascular Implications in Patients Infected with Covid-19 and the Importance of Social Isolation to Reduce Dissemination of the Disease.

Arq Bras Cardiol 2020 Jun;114(5):834-838

Universidade de Vassouras - Cardiologia,Rio de Janeiro, RJ - Brasil.

Respiratory symptoms, especially the development of severe acute respiratory distress syndrome, dominate the discussion and initial concerns of the population and health professionals. However, the cardiovascular system is greatly affected by these conditions and is often responsible for complications and mortality of these patients. In order to show the cardiovascular implications in patients infected with COVID-19 and the importance of social isolation as an alternative to curb the spread of the disease, a literature review was carried out based on 37 articles, in English, Portuguese and Spanish, available on Scielo and PubMed. Read More

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http://dx.doi.org/10.36660/abc.20200243DOI Listing

Staphylococcus aureus growth delay after exposure to low fluencies of blue light (470 nm).

Braz J Biol 2020 May 20. Epub 2020 May 20.

Unidade Acadêmica Especial de Ciências da Saúde, Programa de Pós-graduação em Ciências Aplicadas à Saúde, Universidade Federal de Goiás, Jataí, GO, Brasil.

Antibiotic resistance is one of the greatest challenges to treat bacterial infections worldwide, leading to increase in medical expenses, prolonged hospital stay and increased mortality. The use of blue light has been suggested as an innovative alternative to overcome this problem. In this study we analyzed the antibacterial effect of blue light using low emission parameters on Staphylococcus aureus cultures. Read More

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http://dx.doi.org/10.1590/1519-6984.226473DOI Listing

Complex clinical case with Class III and open bite: stability after seven years.

Dental Press J Orthod 2020 Mar 29;25(2):32-43. Epub 2020 May 29.

Departamento de Ortodontia, Faculdade de Odontologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

A healthy 15-year-old boy with anterior open bite, edge-to-edge transverse discrepancy, and Class III skeletal relationship sought a nonsurgical orthodontic treatment. The patient was treated with premolars extraction, a Hyrax expander and intrusion mechanics with vertical elastics. This mechanics allowed for excellent facial and occlusal results. Read More

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http://dx.doi.org/10.1590/2177-6709.25.2.032-043.oarDOI Listing

Challenges and opportunities for telehealth during the COVID-19 pandemic: ideas on spaces and initiatives in the Brazilian context.

Cad Saude Publica 2020 1;36(5):e00088920. Epub 2020 Jun 1.

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

COVID-19 has created enormous challenges for health systems worldwide, with the rapidly growing number of deaths and critical patients with pneumonia requiring ventilatory support. Alternative methods to control the spread of the disease such as social isolation, extreme quarantine measures, and contact tracing have been used around the world. However, these measures may not be totally effective to fight COVID-19, in step with the necessary national preparations to meet the new patient care demands. Read More

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http://dx.doi.org/10.1590/0102-311x00088920DOI Listing

Sublobar resection in the treatment of elderly patients with early-stage non-small cell lung cancer.

J Bras Pneumol 2020 1;46(4):e20190145. Epub 2020 Jun 1.

Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Surgical resection is the primary treatment option for early-stage non-small cell lung cancer, lobectomy being considered the standard of care. In elderly patients, physiological characteristics can limit the suitability for surgery and the extent of resection. Sublobar resection (SLR) can be offered as an alternative. Read More

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http://dx.doi.org/10.36416/1806-3756/e20190145DOI Listing
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