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    A Case of Topical Ruxolitinib Treatment Failure in Alopecia Areata.
    J Cutan Med Surg 2017 Jun 1:1203475417716363. Epub 2017 Jun 1.
    1 University of Toronto, Toronto, Ontario, Canada.
    Alopecia areata (AA) is an autoimmune-mediated, nonscarring form of hair loss. Despite its prevalence, current management options are limited, especially when the disease has progressed to alopecia totalis (AT) or alopecia universalis (AU). Recent evidence that janus kinase (JAK) signaling contributes to AA pathogenesis prompted the investigation of JAK inhibitors such as tofacitinib and ruxolitinib as possible oral treatments. Read More

    Management of alopecia areata: Updates and algorithmic approach.
    J Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Alopecia areata is a chronic, recurrent and non-scarring alopecia. The prognoses of patients are very diverse. The larger the area of hair loss, the poorer the treatment response and greater the probability of chronic disease progression. Read More

    Excellent response to tofacitinib in a patient with alopecia universalis.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 Jun;26(2):47-49
    Department of Dermatology, Gazi University Hospital, Ankara, Turkey.
    EAlopecia universalis (AU) is generally considered a variant of alopecia areata (AA), in which the treatment options seldom provide satisfactory results. However, successful treatment of several cases of AA and its variants with oral Janus kinase (JAK) inhibitors have been reported recently. Here we report a 23-year-old female patient with AU successfully treated with tofacitinib, a selective JAK-3 inhibitor. Read More

    Methotrexate for the Treatment of Pediatric Alopecia Areata.
    J Dermatolog Treat 2017 Jun 19:1-12. Epub 2017 Jun 19.
    a Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC.
    Alopecia areata is a form of nonscarring hair loss which occurs in pediatric and adult patients, with presentation varying from round or ovoid patches of alopecia to alopecia totalis or universalis. While frustrating for patients, it can also be frustrating for clinicians to treat, as there is no definitive treatment. Dermatologists are very familiar with the use of methotrexate for psoriasis and other inflammatory skin diseases, and this medication is generally well tolerated in children. Read More

    Histologic features of chronic cutaneous lupus erythematosus of the scalp using horizontal sectioning: Emphasis on follicular findings.
    J Am Acad Dermatol 2017 Jun 14. Epub 2017 Jun 14.
    Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts. Electronic address:
    Background: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition.

    Objective: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. Read More

    Exacerbation of alopecia areata: A possible complication of sodium tetradecyl sulphate foam sclerotherapy treatment for varicose veins.
    SAGE Open Med Case Rep 2017 2;5:2050313X17712643. Epub 2017 Jun 2.
    Absolute Aesthetics, Guildford, UK.
    A 40-year-old woman with a history of alopecia areata related to stress or hormonal changes was treated for bilateral primary symptomatic varicose veins (CEAP clinical score C2S) of pelvic origin, using a staged procedure. Her first procedure entailed pelvic vein embolisation of three pelvic veins using 14 coils and including foam sclerotherapy of the tributaries, using 3% sodium tetradecyl sulphate. Following this procedure, she had an exacerbation of alopecia areata with some moderate shedding of hair. Read More

    Higher concentrations of dithranol appear to induce hair growth even in severe alopecia areata.
    Dermatol Ther 2017 Jun 9. Epub 2017 Jun 9.
    Division of Dermatology, Groote Schuur Hospital, University of Cape Town, South Africa.
    Alopecia areata (AA) is the commonest autoimmune cause of non-scarring alopecia. Topical treatments including corticosteroids and irritants maybe beneficial. Studies report variable hair regrowth with dithranol (anthralin) but all used low concentrations (0. Read More

    Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata.
    Exp Ther Med 2017 Jun 5;13(6):2883-2887. Epub 2017 Apr 5.
    Department of Dermatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China.
    Th1/Th2 peripheral blood balance and CD200 expression in patients with severe alopecia areata (SAA) in the active stage were investigated. Fifty patients with active SAA, 50 patients with stable SAA and 50 healthy controls were continuously selected and expression of Th1/Th2 of peripheral T lymphocytes, and peripheral B lymphocytes was detected by flow cytometry; RT-PCR was used to detect the expression of the PBMC CD200 mRNA and the expression of CD200 in hair follicles of alopecia area was detected by immunohistochemically staining; ELISA was used to detect expression levels of serum LFN-γ and serum interleukin (IL)-10. The expression of CD200 in patients with alopecia areata in active phase on CD3(+) T lymphocytes and CD19(+) B lymphocytes was significantly lower (P<0. Read More

    Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata.
    Ann Dermatol 2017 Jun 11;29(3):263-267. Epub 2017 May 11.
    Department of Dermatology, Chungnam National University School of Medicine, Daejeon, Korea.
    Background: Alopecia areata (AA) is an autoimmune skin disease difficult to manage and treat. The pathogenesis of AA features a T-cell-associated autoimmune process, and systemic immunosuppressive therapy is prescribed widely for AA.

    Objective: To evaluate the efficacy and tolerance of systemic low-dose methotrexate (LD-MTX) therapy in treatment of recalcitrant AA multiplex. Read More

    Alopecia Areata of the Beard: A Review of the Literature.
    Am J Clin Dermatol 2017 May 29. Epub 2017 May 29.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave., Miami, FL, 33136, USA.
    Alopecia areata (AA) is a T-cell mediated autoimmune disorder in which inflammatory cells attack the hair follicle, resulting in round, well-circumscribed patches of noncicatricial hair loss in normal appearing skin. AA affecting the beard area is well known and is referred to as AA of the beard (BAA) or AA barbae when involvement is limited exclusively to the beard. BAA has been documented in a select number of studies. Read More

    Phosphodiesterase 4 inhibitors in immune-mediated diseases: mode of action, clinical applications, current and future perspectives.
    Curr Med Chem 2017 May 29. Epub 2017 May 29.
    Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa. Greece.
    Phosphodiesterase (PDE) 4 is a superfamily of enzymes that catalyze the hydrolysis of cyclic adenosine 3',5'-monophosphate (cAMP), an intracellular second messenger and regulator of a wide array of genes and proteins. Increased levels of intracellular cAMP lead to activation of genes but also to inhibition of nuclear factor-kappa B, involved in pro-inflammatory responses. By increasing cAMP levels, PDE4 inhibitors, such as apremilast, reduced production of pro-inflammatory TNFα, IFNγ, and IL-17 and increased production of anti-inflammatory IL-10 in lipopolysaccharide-stimulated peripheral blood mononuclear cells, and in patients with psoriatic arthritis (PsA). Read More

    Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
    Cell 2017 Jun 25;169(6):1119-1129.e11. Epub 2017 May 25.
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:
    The maintenance of tissue homeostasis is critically dependent on the function of tissue-resident immune cells and the differentiation capacity of tissue-resident stem cells (SCs). How immune cells influence the function of SCs is largely unknown. Regulatory T cells (Tregs) in skin preferentially localize to hair follicles (HFs), which house a major subset of skin SCs (HFSCs). Read More

    Alopecia Areata: An Update on Treatment Options for Children.
    Paediatr Drugs 2017 May 27. Epub 2017 May 27.
    The Children's Hospital of Philadelphia and The University of Pennsylvania, Perlman School of Medicine, 3401 Civic Center Blvd, Wood Center Room 3335, Philadelphia, PA, 19104, USA.
    Pediatric alopecia areata is a spectrum of autoimmune non-scarring alopecia in which some patients lose small patches of hair from their scalp but others lose more or all of the hair from the scalp and body, including eyebrows and eyelashes. Few studies have looked at therapies for this disorder in children, so much of the data are derived from adult literature and describe off-label use of medication. Generally, topical therapies consisting of topical steroids and topical irritating compounds/contact sensitizers are used. Read More

    Mechanisms of tolerance and potential therapeutic interventions in Alopecia Areata.
    Pharmacol Ther 2017 May 22. Epub 2017 May 22.
    Translational Biology, Respiratory, Inflammation & Autoimmunity Innovative Medicines Research Unit, AstraZeneca Gothenburg, Sweden. Electronic address:
    This review aims to address the mechanisms of compromised immune tolerance contributing to the development and maintenance of Alopecia Areata (AA). Our goal is to also highlight future treatment opportunities and therapeutics that will safely and efficiently restore hair growth and maintain patients in remission. AA is a presumptive autoimmune disorder that coincides and genetically clusters to several other autoimmune diseases. Read More

    Harefuah 2016 Oct;155(10):622-625
    Dermatology Department, Sheba Medical Center, Sackler Faculty Of Medicine, Tel Aviv University.
    Introduction: Alopecia areata (AA) is an organ specific autoimmune disease. Similar to other autoimmune diseases, its pathogenesis is believed to be an interaction of genetic, environmental and immune factors. Studies have shown that autoreactive lymphocytes affect anagen hair follicles leading to subsequent shedding of hairs and alopecia. Read More

    Efficacy of topical latanoprost versus minoxidil and betamethasone valerate on the treatment of alopecia areata.
    J Dermatolog Treat 2017 Jun 15:1-10. Epub 2017 Jun 15.
    b Department of Pharmaceutical Technology, Faculty of Pharmacy , Tanta University , Tanta , Egypt.
    Background: Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA.

    Objective: To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasone valerate on hair growth in patients with AA. Read More

    Alopecia areata - hyperactivity of the hypothalamic-pituitary-adrenal axis is a myth?
    J Eur Acad Dermatol Venereol 2017 May 18. Epub 2017 May 18.
    Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
    Introduction: Psychological stress is known to cause exacerbation of different skin pathologies including alopecia areata (AA). A hyperactivity of the hypothalamic-pituitary-adrenal axis (the HPA axis) in patients affected by AA (AA patients) was proposed to be a neuroendocrine response to stress. Still little is known about melanocyte-stimulating hormone (MSH) and cortisol production in AA settings. Read More

    Dermoscopy of alopecia areata-a retrospective analysis.
    Dermatol Pract Concept 2017 Apr 30;7(2):53-57. Epub 2017 Apr 30.
    Department of Skin and VD, Patna Medical College & Hospital, Patna, Bihar, India.
    Background: Dermoscopy devices can overcome the refractive properties of stratum corneum by interface medium or cross polarization such that the lesion can be easily seen.

    Aim: To examine the dermoscopic feature in alopecia areata and correlate the severity of disease with dermoscopic features.

    Materials And Methods: Retrospective analysis of 72 patients suffering from alopecia areata (AA), irrespective of age and sex, who visited the dermatology outpatient department of a tertiary care center in Eastern India was carried out. Read More

    Importance of Group Therapeutic Support for Family Members of Children with Alopecia Areata: A Cross-Sectional Survey Study.
    Pediatr Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Minnesota, Minneapolis, MN.
    Background/objectives: The psychological effect of alopecia areata (AA) is well documented, but group interaction may help lessen this burden. We aimed to determine factors that draw patients with AA and their families to group events.

    Methods: Surveys were administered at the annual alopecia areata bowling social in 2015 and 2016. Read More

    Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review.
    Acta Derm Venereol 2017 May 17. Epub 2017 May 17.
    Department of Psychiatry, Oslo University Hospital, NO-0196 Oslo, Norway.
    There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. Read More

    The Role of Micronutrients in Alopecia Areata: A Review.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Dermatology, Warren Alpert Medical School, Brown University, 339 Eddy Street, Providence, RI, 02903, USA.
    Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Read More

    Vitamin D Deficiency in Alopecia Areata.
    J Coll Physicians Surg Pak 2017 Apr;27(4):200-202
    Department of Dermatology, PNS Shifa, Karachi.
    Objective: To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls.

    Study Design: Case-control study.

    Place And Duration Of Study: Dermatology OPD, JPMC, from October 2014 to March 2015. Read More

    Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults.
    J Dermatolog Treat 2017 May 30:1-9. Epub 2017 May 30.
    a Dermatology Department , Istanbul Medipol University, Medical Faculty , Istanbul , Turkey.
    Purpose: To evaluate and compare the clinical efficacy, dermoscopic results and safety of triamcinolone acetonide (TA) and betamethasone dipropionate (BD) injections at different concentrations in localized scalp and beard alopecia.

    Methods: Intralesional injection of BD or TA in three different dilutions; 1/4, 1/8, 1/12 (BD1, BD2, BD3, TA1, TA2, TA3) and Saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients every four weeks in a maximum of six sessions until a hair regrowth score of 4 was achieved. The number of required sessions, sixth-month hair regrowth scores, treatment success rates and dermoscopic data were investigated. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    A mixed methods survey of social anxiety, anxiety, depression and wig use in alopecia.
    BMJ Open 2017 May 4;7(4):e015468. Epub 2017 May 4.
    Department of Psychology, University of Sheffield, Sheffield, UK.
    Objectives: This study aimed to examine levels of social anxiety, anxiety and depression reported by people with alopecia as a result of a dermatological condition and associations with wig use. The study also sought to report on experiences of wearing wigs in social situations and the relationship with social confidence.

    Design: A cross-sectional survey was sent by email to the Alopecia UK charity mailing list and advertised on social media. Read More

    Pediatric Psoriasis: should we be concerned with comorbidities? A cross sectional study.
    Pediatr Int 2017 Apr 28. Epub 2017 Apr 28.
    Department of dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: Similarly to psoriasis in adult, Recent research has linked psoriasis to several comorbidities in children. Our objective was to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature.

    Methods: A cross-sectional study was performed on a sample of Moroccan psoriatic children, during two years 2014 -2016. Read More

    Temperament-Character Profile and Psychopathologies in Patients with Alopecia Areata.
    J Gen Psychol 2017 Apr 27:1-12. Epub 2017 Apr 27.
    c Community Medicine Department, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
    The aim of this study is to investigate psychopathologies and the temperament-character profile of Alopecia Areata patients and to compare them with healthy controls. Patients and controls who presented at a dermatology clinic were selected by convenience sampling to respond to Temperament and Character Inventory (TCI), SCL-90-R, and a checklist about the demographic data and their dermatologic and psychiatric history. Patients reported higher harm avoidance and reward dependence than controls (Cohen's d =. Read More

    Serum vitamin D level is related to disease severity in pediatric alopecia areata.
    J Cosmet Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Endocrinology and Metabolism, Konya Numune Hospital, Konya, Turkey.
    Background: Alopecia areata (AA) is the most common cause of inflammatory hair loss. AA is considered an autoimmune disease and occurs with various autoimmune disorders. Recent studies have revealed connection between autoimmune diseases and vitamin D deficiency. Read More

    Methotrexate in Alopecia Areata: A Report of Three Cases.
    Int J Trichology 2016 Oct-Dec;8(4):188-190
    Department of Dermatology, USC University Hospital Complex, Spain.
    There are few studies about systemic treatment in severe cases of alopecia areata (AA), especially in the pediatric population. Although there is more experience with systemic corticosteroids, recent reports have suggested methotrexate (MTX) as an alternative treatment, with a relatively good outcome. We describe three cases of AA in children treated with MTX, two of them with successful results. Read More

    CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homeostasis and induces autoimmune-like alopecia.
    Exp Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Designed Animal and Transplantation Research Institute, Greenbio Research and Technology, Seoul National University, 1447 Pyeongchang-Ro, Daewha, Pyeongchang, Kangwon, 25354, Korea.
    Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6. Read More

    SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.
    Oncotarget 2017 May;8(20):33432-33443
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Alopecia areata is one of the most common autoimmune diseases resulting from T cell-mediated damage of hair follicles. CD8+ T cells infiltrate hair follicles and are responsible for destruction of hair follicles. However the underlying mechanisms for hair loss remain still obscure. Read More

    The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic Dermatology: New Mechanistic Ideas, Gene Editing, and Therapeutic Breakthroughs.
    J Invest Dermatol 2017 May;137(5):e123-e129
    INSERM UMR 1163, Paris, France; Imagine Institute, Paris, France; University Paris Descartes Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, Paris, France. Electronic address:
    Stunning technological advances in genomics have led to spectacular breakthroughs in the understanding of the underlying defects, biological pathways and therapeutic targets of skin diseases leading to new therapeutic interventions. Next-generation sequencing has revolutionized the identification of disease-causing genes and has a profound impact in deciphering gene and protein signatures in rare and frequent skin diseases. Gene addition strategies have shown efficacy in junctional EB and in recessive dystrophic EB (RDEB). Read More

    The Molecular Revolution in Cutaneous Biology: The Era of Genome-Wide Association Studies and Statistical, Big Data, and Computational Topics.
    J Invest Dermatol 2017 May;137(5):e113-e118
    National Heart and Lung Institute, Imperial College, London, UK. Electronic address:
    The investigation of biological systems involving all organs of the body including the skin is in era of big data. This requires heavy-duty computational tools, and novel statistical methods. Microarrays have allowed the interrogation of thousands of common genetic markers in thousands of individuals from the same population (termed genome wide association studies or GWAS) to reveal common variation associated with disease or phenotype. Read More

    A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece.
    Clin Cosmet Investig Dermatol 2017 3;10:99-104. Epub 2017 Apr 3.
    First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.
    Background: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece.

    Patients And Methods: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Read More

    The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients.
    Ann Dermatol 2017 Apr 24;29(2):156-166. Epub 2017 Mar 24.
    Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
    Background: Alopecia areata (AA) is a T cell-mediated autoimmune disease that targets hair follicles and interrupts hair regrowth. The microenvironment of the effector T cells and their related cytokines may affect immunopathogenesis around the hair bulb/bulge.

    Objective: To determine the contributory roles of the effector T cell subsets and related cytokines to the pathogenesis of AA. Read More

    Review of treatment for alopecia totalis and alopecia universalis.
    Int J Dermatol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dermatology, University of California Irvine, Irvine, CA, USA.
    Alopecia areata (AA) is an autoimmune disease directed at the hair follicle. Although usually limited to patchy hair loss over the scalp (focalis), AA can present as total loss of scalp hair (totalis; AT) or as total loss of both scalp and body hair (universalis; AU). Management of AT and AU can be challenging, and although multiple treatment modalities have been explored, no therapy is currently FDA-approved. Read More

    TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold.
    Dermatol Online J 2017 03 15;23(3). Epub 2017 Mar 15.
    University of Wisconsin, Departments of Internal Medicine and Dermatology, Madison, Wisconsin.
    TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Read More

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