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    [ALOPECIA AREATA].
    Harefuah 2016 Oct;155(10):622-625
    Dermatology Department, Sheba Medical Center, Sackler Faculty Of Medicine, Tel Aviv University.
    Introduction: Alopecia areata (AA) is an organ specific autoimmune disease. Similar to other autoimmune diseases, its pathogenesis is believed to be an interaction of genetic, environmental and immune factors. Studies have shown that autoreactive lymphocytes affect anagen hair follicles leading to subsequent shedding of hairs and alopecia. Read More

    Efficacy of Topical Latanoprost Versus Minoxidil and Betamethasone Valerate on The Treatment of Alopecia Areata.
    J Dermatolog Treat 2017 May 18:1-31. Epub 2017 May 18.
    b Pharmaceutical Technology, Faculty of Pharmacy, Tanta University , Tanta , Egypt.
    Background: Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA.

    Objective: To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasone valerate on hair growth in patients with AA. Read More

    Alopecia Areata - hyperactivity of the hypothalamic-pituitary-adrenal axis is a myth?
    J Eur Acad Dermatol Venereol 2017 May 18. Epub 2017 May 18.
    Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.
    Introduction: Psychological stress is known to cause exacerbation of different skin pathologies including alopecia areata (AA). A hyperactivity of the HPA axis in patients affected by AA (AA-patients) was proposed to be a neuroendocrine response to stress. Still little is known about MSH and cortisol production in AA settings. Read More

    Dermoscopy of alopecia areata-a retrospective analysis.
    Dermatol Pract Concept 2017 Apr 30;7(2):53-57. Epub 2017 Apr 30.
    Department of Skin and VD, Patna Medical College & Hospital, Patna, Bihar, India.
    Background: Dermoscopy devices can overcome the refractive properties of stratum corneum by interface medium or cross polarization such that the lesion can be easily seen.

    Aim: To examine the dermoscopic feature in alopecia areata and correlate the severity of disease with dermoscopic features.

    Materials And Methods: Retrospective analysis of 72 patients suffering from alopecia areata (AA), irrespective of age and sex, who visited the dermatology outpatient department of a tertiary care center in Eastern India was carried out. Read More

    Importance of Group Therapeutic Support for Family Members of Children with Alopecia Areata: A Cross-Sectional Survey Study.
    Pediatr Dermatol 2017 May 16. Epub 2017 May 16.
    Department of Dermatology, University of Minnesota, Minneapolis, MN.
    Background/objectives: The psychological effect of alopecia areata (AA) is well documented, but group interaction may help lessen this burden. We aimed to determine factors that draw patients with AA and their families to group events.

    Methods: Surveys were administered at the annual alopecia areata bowling social in 2015 and 2016. Read More

    Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review.
    Acta Derm Venereol 2017 May 17. Epub 2017 May 17.
    Department of Psychiatry, Oslo University Hospital, NO-0196 Oslo, Norway.
    There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. Read More

    The Role of Micronutrients in Alopecia Areata: A Review.
    Am J Clin Dermatol 2017 May 15. Epub 2017 May 15.
    Department of Dermatology, Warren Alpert Medical School, Brown University, 339 Eddy Street, Providence, RI, 02903, USA.
    Alopecia areata (AA) is a common, non-scarring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Read More

    Vitamin D Deficiency in Alopecia Areata.
    J Coll Physicians Surg Pak 2017 Apr;27(4):200-202
    Department of Dermatology, PNS Shifa, Karachi.
    Objective: To compare the mean Vitamin D level in patients with alopecia areata (AA) with age and gender controlled matched healthy controls.

    Study Design: Case-control study.

    Place And Duration Of Study: Dermatology OPD, JPMC, from October 2014 to March 2015. Read More

    Best dilution of the best corticosteroid for intralesional injection in the treatment of localized alopecia areata in adults.
    J Dermatolog Treat 2017 May 10:1-30. Epub 2017 May 10.
    a Istanbul Medipol University Medical Faculty, Dermatology Department , İstanbul , Turkey.
    Purpose To evaluate and compare the clinical efficacy, dermoscopic results and safety of triamcinolone acetonide (TA) and betamethasone dipropionate (BD) injections at different concentrations in localized scalp and beard alopecia. Methods Intralesional injection of BD or TA in three different dilutions; 1/4, 1/8, 1/12 (BD1, BD2, BD3, TA1, TA2, TA3) and Saline (control) was randomly applied to a total of 231 alopecia patches in 83 patients every four weeks in a maximum of 6 sessions until a hair regrowth score of 4 was achieved. The number of required sessions, sixth-month hair regrowth scores, treatment success rates, and dermoscopic data were investigated. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    A mixed methods survey of social anxiety, anxiety, depression and wig use in alopecia.
    BMJ Open 2017 May 4;7(4):e015468. Epub 2017 May 4.
    Department of Psychology, University of Sheffield, Sheffield, UK.
    Objectives: This study aimed to examine levels of social anxiety, anxiety and depression reported by people with alopecia as a result of a dermatological condition and associations with wig use. The study also sought to report on experiences of wearing wigs in social situations and the relationship with social confidence.

    Design: A cross-sectional survey was sent by email to the Alopecia UK charity mailing list and advertised on social media. Read More

    Pediatric Psoriasis: should we be concerned with comorbidities? A cross sectional study.
    Pediatr Int 2017 Apr 28. Epub 2017 Apr 28.
    Department of dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: Similarly to psoriasis in adult, Recent research has linked psoriasis to several comorbidities in children. Our objective was to describe comorbidities associated with pediatric psoriasis, to investigate their relationship with psoriasis characteristics and severity, and to perform a review of the literature.

    Methods: A cross-sectional study was performed on a sample of Moroccan psoriatic children, during two years 2014 -2016. Read More

    Temperament-Character Profile and Psychopathologies in Patients with Alopecia Areata.
    J Gen Psychol 2017 Apr 27:1-12. Epub 2017 Apr 27.
    c Community Medicine Department, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
    The aim of this study is to investigate psychopathologies and the temperament-character profile of Alopecia Areata patients and to compare them with healthy controls. Patients and controls who presented at a dermatology clinic were selected by convenience sampling to respond to Temperament and Character Inventory (TCI), SCL-90-R, and a checklist about the demographic data and their dermatologic and psychiatric history. Patients reported higher harm avoidance and reward dependence than controls (Cohen's d =. Read More

    Serum vitamin D level is related to disease severity in pediatric alopecia areata.
    J Cosmet Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Endocrinology and Metabolism, Konya Numune Hospital, Konya, Turkey.
    Background: Alopecia areata (AA) is the most common cause of inflammatory hair loss. AA is considered an autoimmune disease and occurs with various autoimmune disorders. Recent studies have revealed connection between autoimmune diseases and vitamin D deficiency. Read More

    Methotrexate in Alopecia Areata: A Report of Three Cases.
    Int J Trichology 2016 Oct-Dec;8(4):188-190
    Department of Dermatology, USC University Hospital Complex, Spain.
    There are few studies about systemic treatment in severe cases of alopecia areata (AA), especially in the pediatric population. Although there is more experience with systemic corticosteroids, recent reports have suggested methotrexate (MTX) as an alternative treatment, with a relatively good outcome. We describe three cases of AA in children treated with MTX, two of them with successful results. Read More

    High dose pulsed corticosteroid therapy combined with Methotrexate for Severe Alopecia Areata of Childhood.
    J Eur Acad Dermatol Venereol 2017 Apr 20. Epub 2017 Apr 20.
    Department of Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Pellegrin-Enfants, CHU de Bordeaux, Bordeaux, France.
    Alopecia areata (AA) in childhood can run a chronic course and worsen over time(1). Spontaneous hair regrowth is rarely appreciated in chronic severe AA(2-4). Our centre described the ineffective use of high dose pulsed corticosteroid therapy (HDPCT) in the long term(1). Read More

    CD80CD86 deficiency disrupts regulatory CD4+FoxP3+T cell homeostasis and induces autoimmune-like alopecia.
    Exp Dermatol 2017 Apr 19. Epub 2017 Apr 19.
    Designed Animal and Transplantation Research Institute, Greenbio Research and Technology, Seoul National University, 1447 Pyeongchang-Ro, Daewha, Pyeongchang, Kangwon, 25354, Korea.
    Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6. Read More

    SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.
    Oncotarget 2017 May;8(20):33432-33443
    Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Alopecia areata is one of the most common autoimmune diseases resulting from T cell-mediated damage of hair follicles. CD8+ T cells infiltrate hair follicles and are responsible for destruction of hair follicles. However the underlying mechanisms for hair loss remain still obscure. Read More

    The Molecular Revolution in Cutaneous Biology: Emerging Landscape in Genomic Dermatology: New Mechanistic Ideas, Gene Editing, and Therapeutic Breakthroughs.
    J Invest Dermatol 2017 May;137(5):e123-e129
    INSERM UMR 1163, Paris, France; Imagine Institute, Paris, France; University Paris Descartes Sorbonne Cité, Paris, France; Department of Genetics, Necker Hospital for Sick Children, Paris, France. Electronic address:
    Stunning technological advances in genomics have led to spectacular breakthroughs in the understanding of the underlying defects, biological pathways and therapeutic targets of skin diseases leading to new therapeutic interventions. Next-generation sequencing has revolutionized the identification of disease-causing genes and has a profound impact in deciphering gene and protein signatures in rare and frequent skin diseases. Gene addition strategies have shown efficacy in junctional EB and in recessive dystrophic EB (RDEB). Read More

    The Molecular Revolution in Cutaneous Biology: The Era of Genome-Wide Association Studies and Statistical, Big Data, and Computational Topics.
    J Invest Dermatol 2017 May;137(5):e113-e118
    National Heart and Lung Institute, Imperial College, London, UK. Electronic address:
    The investigation of biological systems involving all organs of the body including the skin is in era of big data. This requires heavy-duty computational tools, and novel statistical methods. Microarrays have allowed the interrogation of thousands of common genetic markers in thousands of individuals from the same population (termed genome wide association studies or GWAS) to reveal common variation associated with disease or phenotype. Read More

    A retrospective epidemiological study of skin diseases among pediatric population attending a tertiary dermatology referral center in Northern Greece.
    Clin Cosmet Investig Dermatol 2017 3;10:99-104. Epub 2017 Apr 3.
    First Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.
    Background: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece.

    Patients And Methods: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Read More

    The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients.
    Ann Dermatol 2017 Apr 24;29(2):156-166. Epub 2017 Mar 24.
    Department of Dermatology, Dong-A University College of Medicine, Busan, Korea.
    Background: Alopecia areata (AA) is a T cell-mediated autoimmune disease that targets hair follicles and interrupts hair regrowth. The microenvironment of the effector T cells and their related cytokines may affect immunopathogenesis around the hair bulb/bulge.

    Objective: To determine the contributory roles of the effector T cell subsets and related cytokines to the pathogenesis of AA. Read More

    Review of treatment for alopecia totalis and alopecia universalis.
    Int J Dermatol 2017 Apr 5. Epub 2017 Apr 5.
    Department of Dermatology, University of California Irvine, Irvine, CA, USA.
    Alopecia areata (AA) is an autoimmune disease directed at the hair follicle. Although usually limited to patchy hair loss over the scalp (focalis), AA can present as total loss of scalp hair (totalis; AT) or as total loss of both scalp and body hair (universalis; AU). Management of AT and AU can be challenging, and although multiple treatment modalities have been explored, no therapy is currently FDA-approved. Read More

    TNF inhibitor induced alopecia: an unusual form of psoriasiform alopecia that breaks the Renbök mold.
    Dermatol Online J 2017 03 15;23(3). Epub 2017 Mar 15.
    University of Wisconsin, Departments of Internal Medicine and Dermatology, Madison, Wisconsin.
    TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Read More

    Can mindfulness-based interventions improve the quality of life of patients with moderate/severe alopecia areata? A prospective pilot study.
    J Am Acad Dermatol 2017 Apr;76(4):757-759
    Section of Dermatology, Department of Health Sciences, University of Genoa, Genoa, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliera Universitaria (AOU) San Martino-Istituto Nazionale per La Ricerca sul Cancro (IST) Genoa, Italy.

    Two cases of alopecia areata treated with ruxolitinib: a discussion of ideal dosing and laboratory monitoring.
    Int J Dermatol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Background: Alopecia areata is a relatively common condition affecting patients seen in community dermatology clinics. A 2014 study implicated the JAK1/JAK2 inhibitor, ruxolitinib in short-term treatment of alopecia, however little information exists about the long-term use in otherwise healthy individuals in the community setting.

    Methods: A patient with chronic alopecia areata and a patient with acute onset alopecia universalis were treated with oral ruxolitinib for over a year. Read More

    Lupus erythematosus tumidus of the scalp masquerading as alopecia areata.
    Cutis 2017 Feb;99(2):E22-E24
    Dermatology Residency Program, San Antonio Uniformed Services Health Education Consortium, Texas, USA.
    Lupus erythematosus tumidus (LET) is a unique subset of chronic cutaneous lupus erythematosus (CCLE) that generally presents as urticarialike papules and plaques with induration and erythema on the face, trunk, and upper extremities. Lesions rarely present on the scalp or below the waist. We report a unique case of LET on the scalp of a woman that presented clinically as alopecia areata. Read More

    Alopecia areata.
    Nat Rev Dis Primers 2017 Mar 16;3:17011. Epub 2017 Mar 16.
    Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined patches to diffuse or total hair loss, which can affect all hair-bearing sites. Patchy alopecia areata affecting the scalp is the most common type. Read More

    "X" Marks the Spot: An Injection Technique for Alopecia Areata.
    Pediatr Dermatol 2017 Mar;34(2):214-215
    Department of Dermatology, Henry Ford Health System, Detroit, Michigan.
    Children with alopecia areata often have multiple patches of hair loss. When administering intralesional steroid injections, it can be difficult to monitor which areas have already been treated. Additionally, patients and their parents may worry that we did not treat all of the affected areas. Read More

    Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients.
    J Am Acad Dermatol 2017 May 8;76(5):948-957. Epub 2017 Mar 8.
    St John's Institute of Dermatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom; Department of Dermatopathology, St John's Institute of Dermatology, NHS Foundation Trust, Guy's and St Thomas' Hospital, London, United Kingdom. Electronic address:
    Background: Anagen effluvium with reversible scalp alopecia is a known side effect of chemotherapy. However, there are an increasing number of reports in the literature documenting permanent alopecia in patients treated with taxanes.

    Objective: We sought to describe the clinicopathologic features in breast cancer patients who underwent treatment with taxanes and adjuvant hormonal chemotherapy. Read More

    Platelet rich plasma for treatment of non-scarring hair loss: systematic review of literature.
    J Dermatolog Treat 2017 Mar 23:1-8. Epub 2017 Mar 23.
    a Center for Research and Training in Skin diseases and Leprosy, Tehran University of Medical Science , Tehran , Iran.
    Background: Although there are many studies showing the role of platelet rich plasma (PRP) in bone grafts, teeth osteosynthesis, and wound healing, there have been little peer reviewed studies about the safety and efficacy of PRP application in the treatment of hair loss.

    Materials And Methods: In this systematic review, we searched Ovid Medline, Scopus and Web of Knowledge till November 2015 for human studies evaluating the efficacy of PRP for the treatment of non-cicatricial alopecia.

    Results: Among 704 articles retrieved in first search, 18 articles matched our inclusion criteria, 14 for androgenic alopecia and four for alopecia areata. Read More

    Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles.
    Sci Rep 2017 Mar 7;7:44127. Epub 2017 Mar 7.
    Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
    Alopecia areata (AA), a chronic, relapsing, hair-loss disorder, is considered to be a T cell-mediated autoimmune disease. It affects approximately 1.7% of the population, but its precise pathogenesis remains to be elucidated. Read More

    Bimatoprost for the treatment of eyelash, eyebrow and scalp alopecia.
    Expert Opin Investig Drugs 2017 Apr 16;26(4):515-522. Epub 2017 Mar 16.
    b Department of Dermatology and Cutaneous Surgery , University of Miami, Miller School of Medicine , Miami , FL , USA.
    Introduction: Alopecia is a common condition observed among people of all ages. It is a disorder that can involve only the scalp as observed in androgenetic alopecia or scalp and body as in alopecia areata or patients under chemotherapy treatment. There are several treatment options with different safety and efficacy outcomes. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 May;153(5):406-412
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    Escalating dosimetry of UVA-1 in the treatment of alopecia areata.
    Int J Dermatol 2017 Jun 23;56(6):653-659. Epub 2017 Feb 23.
    Dermatology Department, Universidad Autonoma de Nuevo Leon, Facultad de Medicina, University Hospital, Monterrey, Mexico.
    Background: Phototherapy can be an option in unresponsive alopecia areata (AA); however, variable results have been reported with its use. We could not find literature of treatment with UVA-1 in AA. A study was designed to evaluate progressive dosimetry to determine the initial dose and its increments. Read More

    Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata.
    An Bras Dermatol 2017 Jan-Feb;92(1):118-120
    Department of Dermatology of the Instituto Lauro de Souza Lima (ILSL) - Bauru (SP), Brazil.
    Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Read More

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