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    1 OF 79

    Multi-Concentration Level Patch Test Guided Diphenyl Cyclopropenone (DPCP) Treatment in Alopecia Totalis or Alopecia Universalis.
    J Med Assoc Thai 2017 Jan;100(1):86-92
    Background: Diphenylcyclopropenone (DPCP) has proved to be effective in alopecia areata. The present study aimed to shorten the treatment duration of DPCP for achieving optimal outcomes.

    Objective: To evaluate the efficacy of multi-concentration level patch test guided DPCP treatment against conventional protocol by measuring percentage of hair regrowth and duration of treatment. Read More

    Platelet rich plasma for the management of hair loss: Better alone or in combination?
    J Cosmet Dermatol 2018 Jun 14. Epub 2018 Jun 14.
    Centro Dermatológico Estético, Alicante, Spain.
    Platelet-rich plasma (PRP) and autologous protein-based treatments have recently emerged as a potential therapeutic approach for hair loss-related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs. Read More

    Development and pilot-testing of the Alopecia Areata Assessment Tool (ALTO).
    PLoS One 2018 6;13(6):e0196517. Epub 2018 Jun 6.
    Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
    Background: Alopecia areata (AA) is an autoimmune disease characterized by non-scarring hair loss. The lack of a definitive biomarker or formal diagnostic criteria for AA limits our ability to define the epidemiology of the disease. In this study, we developed and tested the Alopecia Areata Assessment Tool (ALTO) in an academic medical center to validate the ability of this questionnaire in identifying AA cases. Read More

    Quality of life in mild and severe alopecia areata patients.
    Int J Womens Dermatol 2018 Jun 4;4(2):91-94. Epub 2017 Sep 4.
    School of Public Health, Gonabad University of Medical Sciences, Gonabad, Iran.
    Background: Alopecia areata is a relapsing hair disorder characterized by a sudden hairloss and has a considerable impact on patient's quality of life. The goal of this study was to determine quality of life among patients with mild and severe forms of alopecia areata and compare the two groups.

    Methods: During one year, 176 patients (96 mild, 80 severe) were selected and asked to complete Dermatology Life Quality Index (DLQI) questionnaires. Read More

    Fibroblast cell-based therapy prevents induction of alopecia areata in an experimental model.
    Cell Transplant 2018 Jan 1:963689718773311. Epub 2018 Jan 1.
    1 Department of Surgery, ICORD (international collaboration on regenerative discoveries), University of British Columbia, Canada.
    Alopecia areata (AA) is an autoimmune hair loss disease with infiltration of proinflammatory cells into hair follicles. Current therapeutic regimens are unsatisfactory mainly because of the potential for side effects and/or limited efficacy. Here we report that cultured, transduced fibroblasts, which express the immunomodulatory molecule indoleamine 2,3-dioxygenase (IDO), can be applied to prevent hair loss in an experimental AA model. Read More

    An investigation of vitamin D status in alopecia areata.
    Clin Exp Med 2018 Jun 4. Epub 2018 Jun 4.
    Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
    Alopecia areata (AA) is a type of non-scarring, recurrent patchy loss of hair in hair-bearing areas and is mostly of autoimmune origin. Previous studies have suggested that some autoimmune diseases were found to be associated with vitamin D deficiency. The current study was designed to assess the levels of serum 25-hydroxy vitamin D and C-reactive protein in AA, as compared with controls and to further identify the association between vitamin D levels and disease severity in patients with AA. Read More

    Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis.
    Acta Derm Venereol 2018 Jun 1. Epub 2018 Jun 1.
    Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyush, 807-8555, Japan, Japan.

    Bimatoprost in Dermatology.
    Indian Dermatol Online J 2018 May-Jun;9(3):224-228
    Department of Skin and V.D, Patna Medical College and Hospital, Patna, Bihar, India.
    Bimatoprost is a prostamide analogue used for treatment of glaucoma in ophthalmology. Surprisingly, the side effects such as increased pigmentation of eyelids and hypertrichosis in patients being treated with prostaglandin analogues for glaucoma have opened new areas of application in various dermatological disorders such as alopecia mainly affecting eyelashes, eyebrows, and vitiligo. Read More

    TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata.
    Hum Antibodies 2018 May 11. Epub 2018 May 11.
    Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: TNF-α -308G/A polymorphism has been investigated in few studies for an association with susceptibility to bullous pemphigoid (BP) and alopecia areata (AA). Yet, these findings had so far not been independently replicated, and no data on a possible association of TNFα -308G/A polymorphism with these diseases in Iranian population were available.

    Objectives: In the present study, a possible effect of TNF-α -308G/A variation on susceptibility to BP or AA disease was evaluated. Read More

    Alopecia areata and the gut-the link opens up for novel therapeutic interventions.
    Expert Opin Ther Targets 2018 Jun 7;22(6):503-511. Epub 2018 Jun 7.
    a Respiratory, Inflammation and Autoimmunity IMED Biotech Unit , AstraZeneca , Gothenburg , Sweden.
    Introduction: This review aims to raise the potential of the modern society's impact on gut integrity often leading to increased intestinal permeability, as a cause or driver of Alopecia Areata (AA) in genetically susceptible people. With the increasing rate of T cell-driven autoimmunity, we hypothesize that there is a common root cause of these diseases that originates from chronic inflammation, and that the gut is the most commonly exposed area with our modern lifestyle. Areas covered: We will discuss the complexity in the induction of AA and its potential link to increased intestinal permeability. Read More

    Comorbidities in vitiligo: comprehensive review.
    Int J Dermatol 2018 May 28. Epub 2018 May 28.
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.
    Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Read More

    Treatment of burn scars in Fitzpatrick phototype III patients with a combination of pulsed dye laser and non-ablative fractional resurfacing 1550 nm erbium:glass/1927 nm thulium laser devices.
    Scars Burn Heal 2018 Jan-Dec;4:2059513118758510. Epub 2018 Feb 23.
    Division of Dermatology, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.
    Introduction: Burn scars cause cosmetic disfigurement and psychosocial distress. We present two Fitzpatrick phototype (FP) III patients with burn scars successfully treated with combination pulsed dye laser (PDL) and non-ablative fractional lasers (NAFL).

    Case 1: A 30-year-old, FP III woman with a history of a second-degree burn injury to the bilateral arms and legs affecting 30% body surface area (BSA) presented for cosmetic treatment. Read More

    When your patient's parent asks: "My child's alopecia areata is not getting better. Should he or she get tested for celiac disease?"
    Pediatr Dermatol 2018 May 25. Epub 2018 May 25.
    Section of Dermatology, Department of Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    The relationship between alopecia areata and celiac disease has been suspected for more than 20 years. For a particular individual with alopecia areata, the risk of coexisting celiac disease and the potential benefit of a gluten-free diet on hair loss or regrowth is known. Despite this limited information, patients often aske dermatologists whether they should undergo celiac disease testing or begin a gluten-free diet. Read More

    Alopecia areata: a review of disease pathogenesis.
    Br J Dermatol 2018 May 23. Epub 2018 May 23.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Alopecia areata is a disorder that results in non-scarring hair loss. The psychological impact can be significant, leading to feelings of depression and social isolation. The disease remains incurable though it has been studied for years. Read More

    Distinguishing immunohistochemical features of alopecia areata from androgenic alopecia.
    J Cosmet Dermatol 2018 May 23. Epub 2018 May 23.
    Autoimmune Bullous Disease Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Distinction between alopecia areata (AA) and androgenic alopecia (AGA) can be made according to clinical presentation and biopsy findings. However, it is sometimes difficult to differentiate them, especially when the diffuse pattern of both AA and AGA is in the differential diagnosis of hair loss in androgen-dependent areas.

    Objectives: To evaluate the characteristics of inflammatory cell infiltration using CD3, CD4, CD8, and CD20 antigens, in AA and AGA to find some consistent histological clues for distinguishing these two entities. Read More

    Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A critically appraised topic.
    Br J Dermatol 2018 May 19. Epub 2018 May 19.
    Dermatology, Leeds Beckett University, Nottingham, UK.
    Aim: To assess the effects of methotrexate for maintaining hair regrowth in alopecia totalis.

    Methods: We critically appraised the literature identified from searching PubMed, Ovid MEDLINE, Ovid Embase and Cochrane Central (October 2017), using the search terms ("alopecia areata" OR "alopecia totalis" OR "alopecia universalis") AND (methotrexate).

    Results: Two prospective studies and 11 retrospective case series were included comprising 226 patients with alopecia varying from 30% hair loss to alopecia universalis at baseline. Read More

    Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology
    Skin Therapy Lett 2018 05;23(3):5-9
    Division of Dermatology, University of Calgary, Calgary, AB, Canada.
    The class of medications known as Janus kinase inhibitors block cytokine-mediated signaling via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, which plays an important role in immunoregulation and normal cell growth. This class includes the drugs tofacitinib, approved for the treatment of rheumatoid arthritis, and ruxolitinib, approved for the treatment of myelofibrosis and polycythemia rubra vera. The most common adverse events (AEs) reported in patients taking tofacitinib are infections, whereas the most common AEs in patients taking ruxolitinib are anemia and thrombocytopenia. Read More

    Mindfulness-Based Cognitive Hypnotherapy and Skin Disorders.
    Am J Clin Hypn 2018 Jul;61(1):34-44
    a University of South Florida , Tampa , FL, USA.
    Mindfulness-based cognitive hypnotherapy integrates mindfulness, cognitive-behavioral therapy, and hypnotherapy to improve physical, emotional, mental, and/or spiritual aspects of skin disorders. Meditation, including mindfulness meditation, and hypnosis both utilize trance phenomena to help produce focalization and specific improvements in skin disorders through psycho-neuro-endocrine-immunologic mechanisms. Hypnosis, cognitive hypnotherapy, focused meditation, and mindfulness meditation are discussed with respect to improving various skin disorders including acne, acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythema nodosum, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, prurigo nodularis, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. Read More

    Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis, and New Treatment Options.
    Int J Trichology 2018 Mar-Apr;10(2):51-60
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Fl 33136, USA.
    Alopecia areata (AA) is a complex autoimmune condition that causes nonscarring hair loss. It typically presents with sharply demarcated round patches of hair loss and may present at any age. In this article, we review the epidemiology, clinical features, pathogenesis, and new treatment options of AA, with a focus on the immunologic mechanism underlying the treatment. Read More

    Complete Regrowth of Beard Hair with Ruxolitinib in an Alopecia Universalis Patient.
    Skin Appendage Disord 2018 Apr 9;4(2):122-124. Epub 2017 Sep 9.
    Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    While most alopecia areata (AA) cases resolve spontaneously, the more severe types of AA, alopecia totalis (AT) and alopecia universalis (AU), can be highly resistant to therapy. We report on a 33-year-old ultraorthodox Jewish man with an 11-year history of AA that resulted in complete loss of the scalp and body hair 7 years ago. Previous treatments with intralesional and systemic corticosteroids had only partial and temporary effects. Read More

    Alopecia Areata in a Dog: Clinical, Dermoscopic and Histological Features.
    Skin Appendage Disord 2018 Apr 9;4(2):112-117. Epub 2017 Sep 9.
    DIMEVET, Faculty of Veterinary Medicine, Milan, Italy.
    Alopecia areata (AA)-like disease is characterized by multifocal patchy hair loss in humans, rodents, dogs, and horses. Remarkable similarities between human and nonhuman AA cases have been reported in terms of clinical presentation, histology, and immune mechanisms of the disease. Canine AA-like lesions most often consist of well-demarcated alopecic patches, frequently but not only involving the face and the head, which extend to the ear pinnae and legs. Read More

    Cellular therapy with human autologous adipose-derived adult cells of stromal vascular fraction for alopecia areata.
    Stem Cell Res Ther 2018 May 15;9(1):141. Epub 2018 May 15.
    Department of Biology, Laboratory of Therapeutic Innovation, Faculty of Sciences 2, Lebanese University, Fanar, Lebanon.
    Background: Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes. Adipose-derived stromal vascular cells (ADSVCs) that can be harvested from fat cells are one of the latest breakthroughs in the aesthetic field. Read More

    Prevalence and comorbidities associated with hidradenitis suppurativa in Korea: a nationwide population-based study.
    J Eur Acad Dermatol Venereol 2018 May 15. Epub 2018 May 15.
    Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
    Background: The prevalence of hidradenitis suppurativa (HS) in Asia is unknown. The associations between HS and other autoimmune disorders have rarely been reported.

    Objective: We sought to determine the prevalence of and diseases associated with HS using the National Health Insurance (NHI) database. Read More

    Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells.
    Cell Death Discov 2018 9;4:53. Epub 2018 May 9.
    2Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Previous expression study using quantitative proteomics has shown that immune-mediated pathway may not be the main mechanism inducing alopecia areata (AA). Nevertheless, functional impact of such expression data set remained unknown and unexplored. This study thus aimed to define potentially novel mechanisms of the AA pathogenesis by functional investigations of the differentially expressed proteins previously identified from lesional biopsies. Read More

    Alopecia universalis in a patient with rheumatoid arthritis developed during treatment with adalimumab.
    Z Rheumatol 2018 May 9. Epub 2018 May 9.
    Institute of Rheumatology, School of Medicine, University of Belgrade, Resavska 69, 11000, Belgrade, Serbia.
    Alopecia universalis is an advanced form of alopecia areata, characterized by complete loss of hair on all hair-bearing areas. It is currently believed to be an autoimmune disorder. The development of alopecia during treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a rarely observed adverse event. Read More

    Alopecia Areata is Associated with Increased Expression of Heart Disease Biomarker Cardiac Troponin I.
    Acta Derm Venereol 2018 May 8. Epub 2018 May 8.
    Department of Dermatology and Skin Science, University of British Columbia, V5Z 4E8 Vancouver, BC, Canada.
    The development of androgenetic alopecia is associated with a risk of developing cardiovascular diseases, but the association of alopecia areata with cardiovascular diseases in humans is largely unexplored. We measured the plasma level of two common cardiovascular disease markers, cardiac troponin I and C-reactive protein, in alopecia areata and androgenetic alopecia affected subjects. Also, we investigated the possible presence of pro-apoptotic factors in the plasma of hair loss subjects. Read More

    Coexistence of chronic cutaneous lupus erythematosus and frontal fibrosing alopecia.
    An Bras Dermatol 2018 Mar;93(2):274-276
    Department of Dermatology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Read More

    Correlation between serum IL-17A level and SALT score in patients with alopecia areata before and after NB-UVB therapy.
    J Cosmet Dermatol 2018 Jun 29;17(3):533-537. Epub 2018 Apr 29.
    Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.
    Background: There is strong evidence that alopecia areata is of immunological background; Interleukin-17 (IL-17) is a Th17 pro-inflammatory cytokine that has been allied to the pathogenesis of different autoimmune and inflammatory diseases.

    Objective: This study aimed to measure serum IL-17A in patients with alopecia areata, and to study associations between IL-17A levels and disease severity before and after Narrowband-Ultraviolet B (NB-UVB), patient gender and age.

    Methods: Twenty patients with AA of the scalp were treated with (NB-UVB), and 15 healthy subjects' age and sex matched were enrolled as controls. Read More

    Perinevoid alopecia: A case report and literature review.
    Br J Dermatol 2018 Apr 28. Epub 2018 Apr 28.
    Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
    Perinevoid alopecia is a rare variant of alopecia areata (AA) associated with a central pigmented nevus, and its pathogenesis is unclear owing to its rarity . A 22-year-old Japanese woman presented with two hairless patches around nevi on the right side of the vertex (Fig. 1a) and back of the scalp (Fig. Read More

    iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata.
    J Autoimmun 2018 Jul 18;91:61-72. Epub 2018 Apr 18.
    Skin Research Laboratory, Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel. Electronic address:
    Alopecia areata (AA) is understood to be a CD8+/NKG2D+ T cell-dependent autoimmune disease. Here, we demonstrate that human AA pathogenesis of is also affected by iNKT10 cells, an unconventional T cell subtype whose number is significantly increased in AA compared to healthy human skin. AA lesions can be rapidly induced in healthy human scalp skin xenotransplants on Beige-SCID mice by intradermal injections of autologous healthy-donor PBMCs pre-activated with IL-2. Read More

    [Dermatologic toxicities of immune checkpoint inhibitors].
    Ann Dermatol Venereol 2018 May 18;145(5):313-330. Epub 2018 Apr 18.
    Oncodermatologie, institut universitaire du cancer Toulouse Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
    The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. Read More

    Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.
    J Am Acad Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    University of California, Irvine, Department of Dermatology, Irvine, CA, 92697.
    Background: Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations.

    Objective: To summarize published evidence on the efficacy, safety, and tolerability of topical JAKi in the treatment of inflammatory skin conditions. Read More

    Traction alopecia: the root of the problem.
    Clin Cosmet Investig Dermatol 2018 6;11:149-159. Epub 2018 Apr 6.
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
    Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. Read More

    Nail involvement in patients with moderate-to-severe alopecia areata treated with oral tofacitinib.
    J Dermatolog Treat 2018 May 7:1-4. Epub 2018 May 7.
    a Department of Dermatology , SMG-SNU Boramae Medical Center , Seoul , Korea.
    Background: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA.

    Objective: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib.

    Methods: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months. Read More

    Increased prevalence of vitamin D deficiency in patients with alopecia areata: a systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Background: Alopecia areata (AA) is a hair follicle-specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency. Read More

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