4,148 results match your criteria Alopecia Areata


The efficacy and safety of targeted narrowband UVB therapy: a retrospective cohort study

Turk J Med Sci 2019 Apr 18;49(2):595-603. Epub 2019 Apr 18.

Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders

Materials And Methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Read More

View Article

Download full-text PDF

Source
http://online.journals.tubitak.gov.tr/openDoiPdf.htm?mKodu=s
Publisher Site
http://dx.doi.org/10.3906/sag-1810-110DOI Listing
April 2019
1 Read

Regulatory T-Cells in alopecia areata.

J Cutan Pathol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, Loyola University Medical Center, Maywood, IL.

Introduction: Alopecia areata (AA) is believed to have an autoimmune mechanism in which the hair follicles are targeted by CD4+ and CD8+ lymphocytes. Studies investigating the autoimmune mechanism of other cutaneous diseases, including vitiligo, demonstrated that Treg are a component of cutaneous immune privilege. Our study uses immunohistochemical staining in formalin-fixed, paraffin embedded tissue to examine the percentage of CD4+FoxP3+, CD25+FoxP3+ and CD8+FoxP3+ Treg in AA in human specimens. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13479
Publisher Site
http://dx.doi.org/10.1111/cup.13479DOI Listing
April 2019
1 Read

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
4 Reads

Identification of blood microRNA alterations in patients with severe active alopecia areata.

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen-stage hair follicle. Lack of efficacious treatment for AA may be due to little knowledge about its exact cellular mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in the regulation of inflammatory skin diseases such as atopic dermatitis and psoriasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28700DOI Listing
April 2019
4 Reads

Alopecia areata is characterised by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease-associated psychological morbidity.

Br J Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

Background: Alopecia areata (AA) is a common autoimmune disease, causing patchy hair loss that can progress to involve the entire scalp (totalis) or body (universalis). CD8 NKG2D T cells dominate hair follicle pathogenesis, but the specific mechanisms driving hair loss are not fully understood.

Objectives: To provide a detailed insight into the systemic cytokine signature associated with AA, and assess the association between cytokines and depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.18008DOI Listing
April 2019
1 Read

Scalp bacterial shift in Alopecia areata.

PLoS One 2019 11;14(4):e0215206. Epub 2019 Apr 11.

Giuliani SpA, Milan, Italy.

The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215206PLOS
April 2019
2 Reads

Predictive factors of response to pulse methylprednisolone therapy in patients with alopecia areata: A follow-up study of 105 Japanese patients.

J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Pulse corticosteroid therapy is effective for alopecia areata (AA) in the early stage. The risk and efficacy of this therapy for patients with several backgrounds, however, remains controversial. To explore the predictive factors of the response and risk factors of this therapy, data from 105 AA patients treated with methylprednisolone (500 mg) i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14871DOI Listing
April 2019
2 Reads

JAK/STAT pathway modulation: Does it work in Dermatology?

Authors:
Özgür Gündüz

Dermatol Ther 2019 Apr 9:e12903. Epub 2019 Apr 9.

Kirikkale University Faculty of Medicine, Department of Dermatology and Venerology, Yenisehir District, Tahsin Duru Avenue, No:14, 71450, Yahsihan / Kirikkale, Turkey.

JAK/STAT is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12903DOI Listing

Generalized hypertrichosis due to secukinumab in a patient with moderate psoriasis: A case of serendipity or zemblanity?

Dermatol Ther 2019 Apr 8:e12894. Epub 2019 Apr 8.

Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, Italy.

After 4 months of therapy with secukinumab, a 67-year-old man with moderate psoriasis developed generalized hypertrichosis, along with PASI 90. The patient denied any drug intake, apart from secukinumab, nor applications of any creams. Moreover, this event did not really bother the patient, thus the therapy was not discontinued and the hypertrichosis is persisting as psoriasis' control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12894DOI Listing
April 2019
1 Read

Case of alopecia areata during dupilumab treatment for atopic dermatitis.

J Dermatol 2019 Apr 3. Epub 2019 Apr 3.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14880DOI Listing
April 2019
6 Reads

Dupilumab Improved Alopecia Areata in a Patient with Atopic Dermatitis: A Case Report.

Acta Derm Venereol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-k, Tokyo 113-8655, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3183DOI Listing
April 2019
4 Reads

Off-label studies on apremilast in dermatology: a review.

J Dermatolog Treat 2019 Apr 2:1-10. Epub 2019 Apr 2.

a Division of Dermatology, Department of Medicine , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Purpose: Apremilast is a phosphodiesterase-4 inhibitor FDA approved for psoriatic arthritis and moderate to severe plaque psoriasis. In recent years, multiple studies have suggested other potential uses for apremilast in dermatology. A summary of these various studies will be a valuable aid to dermatologists considering apremilast for an alternative indication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1589641DOI Listing
April 2019
5 Reads

The use of phosphodiesterase inhibitors for the treatment of alopecia.

J Dermatolog Treat 2019 Apr 2:1-8. Epub 2019 Apr 2.

a Department of Dermatology , University of California Irvine, Irvine , CA , USA.

Background: Hair loss encompasses a group of scarring and nonscarring diseases with limited treatment options. Understanding the pathogenesis of alopecias has led to the experimental use of phosphodiesterase inhibitors (PDEi).

Objective: To perform a systematic review of literature surrounding the use of PDEi for alopecia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1592097DOI Listing
April 2019
5 Reads

Family recurrence risk of alopecia areata in the Faroe Islands.

Clin Exp Dermatol 2019 Mar 30. Epub 2019 Mar 30.

Sect. of Dermatology, Dept. of Medicine, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.

Background: Reports of a positive family history of Alopecia Areata (AA) have led to the assumption of a genetic component. The Faroe Islands population is small, has been isolated until the 20 century and is only served by one dermatology clinic making it highly suitable for genealogical studies.

Aim: To determine the incidence of AA and to estimate the recurrence risk ratio (RRR) in five generations and in a nationwide dermatologist-based AA cohort using the Faroese genealogy database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.13974DOI Listing
March 2019
1 Read

Mast cell recruitment is modulated by hairless skin microbiome.

J Allergy Clin Immunol 2019 Mar 27. Epub 2019 Mar 27.

Department of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

Hairless mice have countless mast cells (MCs) in the skin and a more gram positive microbiome (GPM). MC number normalizes when TLR2, a GPM sensor, is deleted, proving a connection between hair-loss, GPM and MCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.02.033DOI Listing
March 2019
4 Reads

Topographic Phenotypes of Alopecia Areata and Development of a Prognostic Prediction Model and Grading System: A Cluster Analysis.

JAMA Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Institute of Hair and Cosmetic Medicine, Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Importance: Diverse assessment tools and classification have been used for alopecia areata; however, their prognostic values are limited.

Objective: To identify the topographic phenotypes of alopecia areata using cluster analysis and to establish a prediction model and grading system for stratifying prognoses.

Design, Setting, And Participants: A retrospective cohort study of 321 patients with alopecia areata who visited a single tertiary referral center between October 2012 and February 2017 and underwent 4-view photographic assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2018.5894DOI Listing
March 2019
1 Read

Increasing prevalence of alopecia areata in South Korea.

J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/1346-8138.14
Publisher Site
http://dx.doi.org/10.1111/1346-8138.14863DOI Listing
March 2019
5 Reads

Miliary microemboli of the retinal arterioles and choriocapillaris after subcutaneous injection of triamcinolone acetonide.

J Curr Ophthalmol 2019 Mar 3;31(1):98-101. Epub 2018 Jul 3.

Manisa Celal Bayar University, Department of Ophthalmology, Manisa, Turkey.

Purpose: To report a case of triamcinolone crystals associated miliary microemboli of the retinal arterioles and choriocapillaris.

Methods: A 30-year-old woman with alopecia areata on her left auriculotemporal scalp, scheduled for 10 mg/ml triamcinolone acetonide steroid injections (maximum volume of 3 ml per session) for 1 month intervals, presented with a sudden decrease in vision in her left eye after 1 ml injection in a dermatology clinic.

Results: On ocular examination her best corrected visual acuity (BCVA) was hand movement in the left eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joco.2018.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407092PMC
March 2019
4 Reads

Multiple Autoimmune Disorders in Aicardi-Goutières Syndrome.

Pediatr Neurol 2019 Feb 2. Epub 2019 Feb 2.

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Background: Aicardi-Goutières syndrome is an early-onset encephalopathy with presumed immune pathogenesis caused by inherited defects in nucleic acid metabolism. It is a model disease to study systemic autoimmunity, and there are many clinical, genetic, and basic science considerations that underline a possible overlap between Aicardi-Goutières syndrome and systemic lupus erythematosus.

Results: We describe a 15-year-old girl with Aicardi-Goutières syndrome due to compound heterozygous pathogenic variants in SAMHD1 (sterile alpha motif domain and HD domain-containing protein 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pediatrneurol.2019.01.017DOI Listing
February 2019
2 Reads

Laparoscopic Extirpation of Adrenal Gland Ganglioneuroma Incidentally Diagnosed During Evaluation for Patchy Alopecia Areata in an Adolescent Boy.

Med Princ Pract 2019 Mar 22. Epub 2019 Mar 22.

Objective
We present a 17-year-old boy with an incidentally diagnosed left adrenal ganglioneuroma (GN) during the diagnostic work up of alopecia areata (AA).
Clinical Presentation and Intervention
Laboratory investigations revealed only vitamin D deficiency. Laparoscopic adrenalectomy was performed and GN was confirmed histologically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499755DOI Listing
March 2019
2 Reads
1.113 Impact Factor

Alopecia areata and itch: a retrospective analysis of 312 cases.

Authors:
Y B Lee W S Lee

J Eur Acad Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15591DOI Listing
March 2019
2 Reads

Case report of novel combination of anthralin and calcipotriene leading to trichologic response in alopecia areata.

JAAD Case Rep 2019 Mar 1;5(3):258-260. Epub 2019 Mar 1.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403115PMC
March 2019
3 Reads

Does Immunosuppression Help Control Alopecia Areata? A Study in Transplant Recipients.

Skinmed 2019 19;17(1):18-22. Epub 2019 Mar 19.

Department of Dermatology, Hospital Clínico San Carlos, Madrid, Spain.

Alopecia areata (AA) is a polygenic autoimmune disease. The immunosuppressant drugs taken by patients who undergo solid organ transplantation might therefore be useful in its control. The literature, however, contains conflicting information in this regard. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Alopecia areata: a long-term follow-up study of 104 patients.

J Eur Acad Dermatol Venereol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: Alopecia areata (AA) is a common autoimmune disease that considerably affects the quality of life. Although several studies have investigated the epidemiology, clinical characteristics and treatment of AA, limited recent data are available regarding its long-term course.

Objectives: To evaluate the long-term course of AA in different age groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15582DOI Listing
March 2019
1 Read

Fractional Carbon Dioxide Laser in Combination with Topical Corticosteroid Application in Resistant Alopecia Areata: A Case Series.

J Cutan Aesthet Surg 2018 Oct-Dec;11(4):217-221

CUTIS Institute of Dermatology, Srinagar, India.

Introduction: Intradermal steroid injections are used as treatment option in resistant alopecia areata. However, it is difficult and quite painful to treat large areas of alopecia with this modality.

Objective: To assess the efficacy and safety profile of a combination of fractional carbon dioxide (CO) treatment followed by topical corticosteroid application in resistant alopecia areata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/JCAS.JCAS_96_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371723PMC
March 2019
2 Reads

Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/2077-0383/8/3/347
Publisher Site
http://dx.doi.org/10.3390/jcm8030347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462981PMC
March 2019
7 Reads

A Nationwide, Population-based Cohort Study on Potential Autoimmune Association of Ménière Disease to Atopy and Vitiligo.

Sci Rep 2019 Mar 13;9(1):4406. Epub 2019 Mar 13.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konyang University, Daejeon, Republic of Korea.

Ménière disease (MD), an idiopathic disorder of sensorineural hearing loss and vertigo, shares many similarities with two common skin conditions, atopic dermatitis (AD) and vitiligo. Recent studies have suggested that MD may be related to or triggered by autoimmune conditions, notably Hashimoto thyroiditis and alopecia areata. These evidences led to the authors contemplating the possibility of immunological bridge between MD and the two skin conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-40658-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416401PMC
March 2019
1 Read

Regulatory T cells in inflammatory skin disease: from mice to humans.

Int Immunol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Medical Sciences Building, University of California, San Francisco, CA, USA.

The skin is the largest organ in the body and one of the primary barriers to the environment. In order to optimally protect the host, the skin is home to numerous immune cell subsets that interact with each other and other non-immune cells to maintain organ integrity and function. Regulatory T cells (Tregs) are one of the largest immune cell subsets in skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxz020DOI Listing
February 2019
6 Reads
2.536 Impact Factor

Evaluation of selected parameters of oxidative stress in patients with alopecia areata.

Postepy Dermatol Alergol 2019 Feb 27;36(1):115-116. Epub 2019 Feb 27.

Department of Medical Biology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/pdia.2017.71237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409877PMC
February 2019
3 Reads

Serum concentrations of selected proinflammatory cytokines in children with alopecia areata.

Postepy Dermatol Alergol 2019 Feb 22;36(1):63-69. Epub 2019 Feb 22.

Department of Dermatology, Pediatric and Oncological Dermatology, Medical University of Lodz, Lodz, Poland.

Introduction: Alopecia areata (AA) is considered an autoimmune disorder characterized by patchy loss of hair from the scalp and other body parts. Many patients develop the disease in childhood.

Aim: To answer the question whether abnormal production of some proinflammatory cytokines (IL-2, IL-6, IL-15, IL-17A and IFNγ) in children with AA may facilitate the development or progression of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/ada.2019.82826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409873PMC
February 2019
3 Reads

Vitamin D and the Skin: A Review for Dermatologists.

Actas Dermosifiliogr 2019 Mar 8. Epub 2019 Mar 8.

Servicio de Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, España.

In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00017310183053
Publisher Site
http://dx.doi.org/10.1016/j.ad.2018.08.006DOI Listing
March 2019
11 Reads

What's New in Hair Loss.

Dermatol Clin 2019 Apr;37(2):137-141

Municipal Public Servant Hospital of São Paulo, Rua Castro Alves 60, São Paulo, SP 01532-000, Brazil. Electronic address:

The treatment of hair loss is a challenge for all dermatologists. New medications are needed due to lack of efficacy of many treatments or their side-effect profile. This article discusses the most recent literature updates on the use of retinoids in frontal fibrosing alopecia, platelet-rich plasma in androgenetic alopecia, and JAK inhibitors in alopecia areata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.det.2018.11.002DOI Listing
April 2019
1 Read

Use of trichoscopy for the diagnosis of alopecia areata coexisting with primary scarring alopecia in a female hair loss patient.

J Dermatol 2019 Mar 7. Epub 2019 Mar 7.

Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo, Japan.

Despite patchy hair loss being typically observed in alopecia areata (AA), similar lesions can be seen in other forms of alopecia and the diagnosis is sometimes challenging. Of note, patchy primary scarring alopecia (SA) needs to be clearly distinguished from AA as SA can leave permanent hair loss. Herein, we report a previously unreported case of AA coexisting with SA successfully diagnosed by detailed trichoscopic investigation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/1346-8138.14841
Publisher Site
http://dx.doi.org/10.1111/1346-8138.14841DOI Listing
March 2019
8 Reads

Amyloid-Associated Alopecia: A Reappraisal Including Its Pathophysiology.

Am J Dermatopathol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH.

Primary systemic amyloidosis has a varied clinical presentation, making it one of the great masqueraders of other disease entities in clinical medicine. The association of amyloidosis with alopecia is uncommon with at least 22 cases reported in the literature mostly in the setting of systemic amyloidosis. Alopecia in these patients occurs either as the initial presentation of the systemic amyloidosis or it happens during the disease course. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001385DOI Listing
February 2019
3 Reads

Minoxidil for Patchy Alopecia Areata: Systematic Review and Meta-Analysis.

J Eur Acad Dermatol Venereol 2019 Mar 5. Epub 2019 Mar 5.

Professor of Evidence-Based Medicine and Emergency Medicine, Universidade Federal de São Paulo, Brazil, Director of the Brazilian Cochrane Centre.

Alopecia areata (AA) is a complex immune and polygenic inflammatory disease that causes hair loss on some or all areas of the body; extent, severity and progression vary widely among individuals. Alopecia areata, considered one of the most frequently occurring immune diseases, affects 0.2% of the world population at any given time. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jdv.15545
Publisher Site
http://dx.doi.org/10.1111/jdv.15545DOI Listing
March 2019
5 Reads

Alopecia Areata After Treatment with Dupilumab.

Dermatitis 2019 Mar/Apr;30(2):175-176

Department of Dermatology Roskilde Hospital Health Sciences Faculty University of Copenhagen Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DER.0000000000000458DOI Listing
March 2019
3 Reads

Serum Interleukin-15 is a Marker of Alopecia Areata Severity.

Int J Trichology 2019 Jan-Feb;11(1):26-30

Dermatology and Leprosy Clinic, Damanhour, El- Beheira, Egypt.

Background: Interleukin-15 (IL-15) is a cytokine that is involved in many inflammatory and autoimmune diseases. Although alopecia areata (AA) is an autoimmune disease, serum levels of IL-15 have not been studied well in AA patients.

Aim Of The Work: We aims at evaluating the serum levels of IL-15 in active AA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijt.ijt_80_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385510PMC
March 2019
2 Reads

Tubular Hair Casts in Trichoscopy of Hair and Scalp Disorders.

Int J Trichology 2019 Jan-Feb;11(1):14-19

Department of Dermatology, College of Medical Sciences, Bharatpur, Nepal.

Introduction: Hair casts have been reported in a variety of hair and scalp disorders. Trichoscopy allows a quick and noninvasive method for the evaluation of hair and scalp disorders in high magnification. However, the study of hair casts seen in trichoscopy is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijt.ijt_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385511PMC
March 2019
12 Reads

Ustekinumab for skin reactions associated with anti-tumor necrosis factor-α agents in patients with inflammatory bowel diseases: A single-center retrospective study.

J Dermatol 2019 Apr 28;46(4):322-327. Epub 2019 Feb 28.

Department of Dermatology, Courlancy Clinic, Rheims, France.

Anti-tumor necrosis factor (TNF)-α agents may induce skin reactions, in particular in patients with inflammatory bowel diseases (IBD). The objective of this study was to determine the efficacy of ustekinumab in these patients. IBD patients facing therapeutic issues because of cutaneous reactions or tolerance issues, consequently treated with ustekinumab in our department, were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14816DOI Listing
April 2019
1 Read

Perinevoid Alopecia: A Case Report.

Skin Appendage Disord 2019 Feb 18;5(2):94-96. Epub 2018 Jul 18.

Department of Dermatopathology, "Dr. Manuel Gea González" General Hospital, Mexico City, Mexico.

Perinevoid alopecia has been described as an associated alopecia surrounding a pigmented nevus due to an inflammatory response against nevus structures. It is described as a part of other nevocentric phenomena in which a cellular inflammatory response against nevus antigens develops. A 35-year-old male presented with a unique area of non-scarring alopecia surrounding an asymptomatic, pigmented nevus with a 1-month evolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000490469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388562PMC
February 2019
2 Reads

Association of Out-of-Pocket Health Care Costs and Financial Burden for Patients With Alopecia Areata.

JAMA Dermatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2018.5218DOI Listing
February 2019
1 Read

JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis.

Rheumatology (Oxford) 2019 Feb;58(Supplement_1):i43-i54

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of molecules associated with one of the major pathways through which many cytokines exert and integrate their function, and as such they are increasingly recognized as playing critical role in the pathogenesis subserving various immune-mediated diseases, including RA, PsA, SpAs, IBD, skin disorders (e.g. alopecia areata, atopic dermatitis), single-gene disorders like interferonopathies, and others. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/key276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390879PMC
February 2019
4 Reads

The Efficacy of Topical Minoxidil for Non-Scarring Alopecia: A Systematic Review

J Drugs Dermatol 2019 Feb;18(2):155-160

Introduction: Topical minoxidil is the first-line therapy for treating both male and female androgenetic alopecia. Currently there are no comprehensive reviews on the clinical efficacy of minoxidil on hair loss. Method: A literature search was conducted to identify clinically relevant studies regarding the efficacy of topical minoxidil for human subjects for hair loss. Read More

View Article

Download full-text PDF

Source
February 2019
3 Reads

Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata.

J Cell Biochem 2019 Jun 20;120(6):10737-10747. Epub 2019 Feb 20.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs) and indirectly interact with messenger RNA (mRNAs). However, the roles of specific lncRNA and its related competing endogenous RNAs (ceRNA) network in alopecia areata (AA) are not fully understood.

Methods: The blood lncRNA profiles were obtained by microarray from 10 samples, including five alopecia areata samples and five normal samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28365DOI Listing
June 2019
3 Reads

Nuchal Nevus Flammeus and Alopecia Areata: When Size Matters.

Int J Trichology 2018 Nov-Dec;10(6):275-277

Department of Dermatology, Hospital Clínic de Barcelona, Barcelona, Spain.

Introduction: Alopecia areata (AA) is a high-prevalence immuno-mediated hair loss disorder. Extra follicular affections, including nail and ocular abnormalities, are classically related to a worse prognosis of the disease, and previous studies have suggested that the presence of a persistent nuchal nevus flammeus (NNF) also indicates a greater severity and duration of the disease. The association between AA and persistent NNF was first described by Hatzis et al in 1988, who demonstrated that the relation was statistically evident and not due to a simple observer bias. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijt.ijt_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369638PMC
February 2019
2 Reads

The Impact of Alopecia Areata on Sexual Quality of Life.

Int J Trichology 2018 Nov-Dec;10(6):271-274

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Alopecia areata (AA) is an autoimmune disease characterized by patches of hair loss that can cause decreased quality of life. This study evaluates the sexual quality of life for patients with AA.

Methods: We surveyed patients in the National Alopecia Areata Foundation patient registry using an online version of the validated Sexual Quality of Life for Females (SQOL-F) and Sexual Quality of Life for Males (SQOL-M) questionnaires. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijt.ijt_93_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369646PMC
February 2019
1 Read

Evaluation of Association of Vitamin D in Alopecia Areata: A Case-control Study of 100 Patients in a Tertiary Rural Hospital of Southern India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):45-49

Department of Dermatology, Raja Rajeswari Medical College and Hospital, Kambipura, Mysore Road, Bangalore, Karnataka, India.

Background: Alopecia areata is a common autoimmune disorder which is characterized by non-scarring hair loss. Vitamin D plays an important role in immune regulation, cell growth, differentiation, and maintenance of hair cycle.

Aims And Objectives: (1) To evaluate serum vitamin D levels in alopecia areata. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_84_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362755PMC
February 2019

Clinico-Epidemiological Profile of Patients with Vitiligo: A Retrospective Study from a Tertiary Care Center of North India.

Indian Dermatol Online J 2019 Jan-Feb;10(1):38-44

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.

Background: We studied clinico-epidemiological features of 945 patients with vitiligo with an objective to delineate epidemiological and clinical aspects of vitiligo from this part of the country.

Materials And Methods: The medical records of patients with vitiligo attending outpatient clinic over a 5-year period from January 2013 to December 2017 were analyzed retrospectively for this descriptive, observational study.

Results: There were 449 men and 496 women (m:f 1:1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_124_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362747PMC
February 2019
13 Reads

JAK inhibitors for alopecia areata: a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia.

There have been a number of case reports and small clinical trials reporting promising outcomes of Janus Kinase (JAK) inhibitors tofacitinib, ruxolitinib and baricitinib for alopecia areata (AA). The majority of the literature to date is based on small volume data, with a lack of definitive evidence or guidelines. To determine the expected response of AA to JAK inhibitor therapy and factors which influence response and recurrence rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15489DOI Listing
February 2019
2 Reads

Ischemic modified albumin as a new biomarker in predicting oxidative stress in alopecia areata

Turk J Med Sci 2019 Feb 11;49(1):129-138. Epub 2019 Feb 11.

Background/aim: Results show that oxidative stress is a pathophysiologic factor for alopecia areata (AA); however, the markers used can be confounding. Thus, we aimed to investigate the role of oxidative stress in the pathogenesis of AA through an evaluation of ischemia-modified albumin (IMA); other markers of the oxidant/antioxidant system, such as SOD, CAT, GSH-ST, and MDA; and contributing clinical risk factors.

Materials And Methods: The usefulness of IMA as a new marker for oxidative stress was compared with that of other markers and evaluated in patients with AA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3906/sag-1708-35DOI Listing
February 2019
1 Read