4,465 results match your criteria Alopecia Areata


Selenium levels and skin diseases: systematic review and meta-analysis.

J Trace Elem Med Biol 2020 May 20;62:126548. Epub 2020 May 20.

Department of Dermatology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China. Electronic address:

Background: Several studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.

Objective: This systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.

Methods: A systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126548DOI Listing

Onset of Schamberg's disease and resolution of alopecia areata during treatment of atopic dermatitis with dupilumab.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Unit of Dermatology, University of Padua, Padua, Italy.

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http://dx.doi.org/10.18176/jiaci.0541DOI Listing

Dithranol: An insight on its novel delivery cargos for psoriasis management.

Curr Drug Res Rev 2020 May 25. Epub 2020 May 25.

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana. India.

Objective: Dithranol (DTH) is a promising well known moiety that has long been used to impede and treat skin disorders, particularly psoriasis. Now a days, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused interest of scientific community in novel cargos for psoriasis management. Read More

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http://dx.doi.org/10.2174/2589977512666200525154954DOI Listing

Comparative Study between Fractional Carbon Dioxide Laser vs Intralesional Steroid injection in Treatment of Alopecia Areata.

Dermatol Ther 2020 Jun 1. Epub 2020 Jun 1.

Dermatology, Venereology and Andrology Department, Ain Shams University Hospitals, Cairo, Egypt.

Few studies have reported Fractional Carbon Dioxide (FCO2) laser use in treating Alopecia Areata (AA), yet, effectiveness of this therapy has not been comparatively analyzed. To assess efficacy and safety of FCO2 laser in comparison to traditional intralesional corticosteroids injection (ILCs) in treatment of AA. This study included 20 patients with at least 2 patches of AA. Read More

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http://dx.doi.org/10.1111/dth.13742DOI Listing

Ocrelizumab-induced alopecia areata-A series of five patients from Ontario, Canada: A case report.

SAGE Open Med Case Rep 2020 6;8:2050313X20919614. Epub 2020 May 6.

Division of Dermatology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Ocrelizumab is a humanized monoclonal antibody that targets the CD20 antigen found on B-cells. It is indicated in the treatment of both relapsing-remitting multiple sclerosis and primary progressive multiple sclerosis.

Objective: The aim of this study is to report and describe the characteristics of alopecia areata following treatment with ocrelizumab for multiple sclerosis. Read More

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http://dx.doi.org/10.1177/2050313X20919614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233903PMC

Effective use of oral tofacitinib and phototherapy in a patient with concomitant alopecia areata, vitiligo, and plaque and inverse psoriasis.

Clin Case Rep 2020 May 27;8(5):819-822. Epub 2020 Feb 27.

Department of Dermatology Warren Alpert Medical School Brown University Providence RI USA.

This case presentation suggests that tofacitinib combined with phototherapy may be an effective treatment option for patients with concomitant alopecia areata, vitiligo, and different phenotypes of psoriasis including plaque and inverse psoriasis. Read More

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http://dx.doi.org/10.1002/ccr3.2759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250974PMC

Foreign Body Reaction Due To Intralesional Steroid Injection In Treatment Of Alopecia Areata.

Dermatol Ther 2020 May 31:e13703. Epub 2020 May 31.

Fırat Universty Radiology Department, Elazığ.

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http://dx.doi.org/10.1111/dth.13703DOI Listing

Interferon-gamma (IFN-γ) Serum Level and Immunohistochemical expression of CD8 cells in tissue biopsies in patients with Alopecia areata in correlation with the trichoscopic findings.

Dermatol Ther 2020 May 29:e13718. Epub 2020 May 29.

Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University.

Alopecia areata is an autoimmune form of non-scarring hair loss Aim: to assess the serum concentration of IFN-γ and CD8 cell expression in lesional skin biopsies in correlation with the disease severity, activity, duration and trichoscopic findings in patients with alopecia areata.

Patients And Methods: the study included 30 patients with AA and 15 age and sex matched healthy controls. Trichoscopy was performed and Photographs were captured for the alopecic areas, ELIZA technique was used for serum level of interferon-gamma assessment and immunohistochemiistry for CD8 cells. Read More

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http://dx.doi.org/10.1111/dth.13718DOI Listing

Association between major depressive disorder and subsequent autoimmune skin diseases: A nationwide population-based cohort study.

J Affect Disord 2020 May 25;274:334-338. Epub 2020 May 25.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

Background: Major depressive disorder (MDD) has been implicated as a risk factor for various immune-related disorders; however, the association between MDD and subsequent autoimmune skin diseases (ASDs) remains unclear. This study aimed to investigate the association of MDD with risk of subsequent ASDs.

Methods: Subjects were recruited from the National Health Insurance Research Database in Taiwan. Read More

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http://dx.doi.org/10.1016/j.jad.2020.05.070DOI Listing

Expression of CD117 and platelet-derived growth factor receptor α in patients with alopecia areata.

Indian J Dermatol Venereol Leprol 2020 May 27. Epub 2020 May 27.

Department of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry, India.

Background: Alopecia areata is a disease of uncertain, probably autoimmune etiology. The role of growth factors like platelet-derived growth factor and C-kit (CD117) in alopecia areata is unknown.

Aims: To compare the expression of CD117 and platelet-derived growth factor receptor α in tissue samples of alopecia areata and normal controls. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_557_19DOI Listing

Comment on "Azathioprine in combination with methotrexate: a therapeutic alternative in severe and recalcitrant forms of alopecia areata?"

J Eur Acad Dermatol Venereol 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, Jodhpur, 342005, India.

We went through the article with great interest and we appreciate the innovative effort of the authors. Authors found that a combination of methotrexate (MTX) and azathioprine (AZA) showed encouraging results in a series of patients with severe, recalcitrant and cosmetically unacceptable multiple alopecia areata (AA) and alopecia totalis (AT). They proposed that this combination immunosuppressive therapy could be justified since the pathogenesis of AA is based on immunological disturbances in skin. Read More

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http://dx.doi.org/10.1111/jdv.16675DOI Listing

A transcriptomic map of murine and human alopecia areata.

JCI Insight 2020 May 26. Epub 2020 May 26.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa City, United States of America.

Alopecia areata (AA) is one of the most common autoimmune conditions, presenting initially with loss of hair without other overt skin changes. The unremarkable appearance of the skin surface contrasts with the complex immune activity occurring at the hair follicle. AA pathogenesis is due to the loss of immune privilege of the hair follicle leading to autoimmune attack. Read More

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http://dx.doi.org/10.1172/jci.insight.137424DOI Listing

Different freezing time of superficial liquid nitrogen cryotherapy in treatment of recalcitrant alopecia areata: Randomized clinical trial.

Dermatol Ther 2020 May 22:e13640. Epub 2020 May 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Assiut University, Asyut, Egypt.

Recalcitrant alopecia areata is not uncommon in clinical practice and some patients experienced either treatment failure or recurrence with most of the conventional therapies. Several studies have evaluated the efficacy of cryotherapy in the treatment of alopecia areata with controversial results. This study aimed to optimize the ideal timing of liquid nitrogen cryospraying to achieve the most favorable results. Read More

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http://dx.doi.org/10.1111/dth.13640DOI Listing

A comparison of the efficacy and tolerability of three corticosteroid treatment regimens in patients with alopecia areata.

J Dermatolog Treat 2020 May 22:1-21. Epub 2020 May 22.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Topical corticosteroids (TC) and/or intralesional corticosteroids (IC) are considered first-line treatments for patch-type alopecia areata (AA). However, the efficacies of TC monotherapy, IC monotherapy, and combined topical and intralesional corticosteroids (CC) in patients with AA have never been compared. To evaluate and compare the efficacy and tolerability of 3 corticosteroid treatments (TC, IC, and CC) in patients with AA. Read More

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http://dx.doi.org/10.1080/09546634.2020.1773384DOI Listing

Clinical and trichoscopic evaluation of trichloroacetic acid 35% vs phenol 88% peels in treatment of alopecia areata.

J Cosmet Dermatol 2020 May 21. Epub 2020 May 21.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background: Among alopecia areata (AA) treatments, contact irritants (anthralin) and topical immunotherapies (diphenylcyclopropenone) have been successfully used. Chemoexfoliation can potentially be utilized, acting as irritants and consecutively immunomodulators. Peels via therapeutic wounding provoke growth factors and cytokines that may induce hair regrowth. Read More

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http://dx.doi.org/10.1111/jocd.13465DOI Listing

UV308 excimer lamp phototherapy for the treatment of alopecia areata: A randomized, self-controlled study.

Photodermatol Photoimmunol Photomed 2020 May 16. Epub 2020 May 16.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1111/phpp.12570DOI Listing

Impact of Rheumatoid Arthritis on Alopecia: A Nationwide Population-Based Cohort Study in Taiwan.

Front Med (Lausanne) 2020 28;7:150. Epub 2020 Apr 28.

Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Taichung, Taiwan.

Studies on the relationship between rheumatoid arthritis (RA) and alopecia areata (AA) are limited. This study investigated the effect of RA on alopecia areata risk in a nationwide cohort study. We analyzed 2000-2012 data from the Longitudinal Health Insurance Database in Taiwan. Read More

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http://dx.doi.org/10.3389/fmed.2020.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198783PMC

Predictive Metagenomic Profiling, Urine Metabolomics, and Human Marker Gene Expression as an Integrated Approach to Study Alopecia Areata.

Front Cell Infect Microbiol 2020 29;10:146. Epub 2020 Apr 29.

Human Microbiome Advanced Project-HMPA, Giuliani SpA, Milan, Italy.

Involvement of the microbiome in many different scalp conditions has been investigated over the years. Studies on the role of the scalp microbiome in specific diseases, such as those involving hair growth alterations like non-cicatricial [androgenetic alopecia (AGA), alopecia areata (AA)] and cicatricial alopecia lichen planopilaris, are of major importance. In the present work, we highlighted the differences in microbial populations inhabiting the scalp of AA subjects and a healthy sample cohort by using an integrated approach relying on metagenomic targeted 16S sequencing analysis, urine metabolomics, and human marker gene expression. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201066PMC
April 2020
2.620 Impact Factor

Time-Dependent Risk of Acute Myocardial Infarction in Patients With Alopecia Areata in Korea.

JAMA Dermatol 2020 May 13. Epub 2020 May 13.

Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea.

Importance: Alopecia areata (AA) is a common autoimmune disease presenting as nonscarring hair loss. Although AA can be associated with other autoimmune comorbidities or atopic diseases, little is known about the risk of cardiovascular diseases in patients with AA.

Objective: To investigate the risk of acute myocardial infarction (AMI) and cardiovascular risk profiles (CVRPs) in patients with AA via a large-scale epidemiologic study. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221866PMC

Seasonal Variation in Chronic Skin Diseases: Real-World Evidence from a Nationwide Population-based Study in Korea.

J Eur Acad Dermatol Venereol 2020 May 9. Epub 2020 May 9.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Seasonality is clinically indicated in several chronic skin diseases;[1] however, the epidemiologic data supporting these indications are often lacking. Such information would therefore be of great interest to clinicians due to its significant implications to public health. In this study, we conducted a nationwide, population-based, cross-sectional study to examine the seasonality of common chronic skin diseases, including atopic dermatitis (AD), psoriasis, vitiligo, and alopecia areata (AA). Read More

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http://dx.doi.org/10.1111/jdv.16612DOI Listing

Alopecia Areata and Particulate Matter: A 5-year Retrospective Study in Korea.

Authors:
Y B Lee W S Lee

J Eur Acad Dermatol Venereol 2020 May 9. Epub 2020 May 9.

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Alopecia areata (AA) is an autoimmune skin disease induced by CD8+NKG2D+T-cell-mediated immune privilege collapse around the hair follicles. However, the events that trigger the initial overactivity of T-cells have not yet been clarified. Particulate matter (PM), a major airborne pollutant, affects cutaneous dermatoses beyond other organs. Read More

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http://dx.doi.org/10.1111/jdv.16611DOI Listing

Cross-sectional study of blood biomarkers of patients with moderate-to-severe alopecia areata reveals systemic immune and cardiovascular biomarker dysregulation.

J Am Acad Dermatol 2020 May 3. Epub 2020 May 3.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Background: Although there is increased understanding of the alopecia areata/AA pathogenesis based on studies in scalp tissues, little is known about its systemic profile.

Objective: To evaluate the blood proteomic signature of AA and determine biomarkers associated with increased disease severity.

Methods: In a cross-sectional study, we assessed 350 inflammatory and cardiovascular proteins using OLINK high-throughput proteomics in moderate-to-severe AA patients (n=35), as compared with healthy individuals (n=36), moderate-to-severe psoriasis (n=19), and atopic dermatitis/AD patients (n=49). Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.138DOI Listing

Trichostasis spinulosa misdiagnosed as alopecia areata.

Dermatol Ther 2020 May 6:e13513. Epub 2020 May 6.

University of Studies Guglielmo Marconi, Rome, Italy.

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http://dx.doi.org/10.1111/dth.13513DOI Listing

Successful Treatment of Alopecia Areata Barbae with Platelet-rich Plasma.

Cureus 2020 Apr 1;12(4):e7495. Epub 2020 Apr 1.

Orthopaedics, Privatpraxis Josephsburg, Munich, DEU.

Alopecia areata (AA) is a frequent autoimmune disorder in which inflammatory cells attack the hair follicles. AA affecting the beard area is well known and is referred to as alopecia areata barbae (AAB) when involvement is limited exclusively to the beard. Currently, no guidelines are established for specific therapeutic approaches for this condition. Read More

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http://dx.doi.org/10.7759/cureus.7495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193229PMC

A comprehensive review of biochemical factors in herbs and their constituent compounds in experimental studies on alopecia.

J Ethnopharmacol 2020 Aug 28;258:112907. Epub 2020 Apr 28.

Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, South Korea. Electronic address:

Ethnopharmacological Relevance: Alopecia is a chronic condition that may cause emotional and psychological distress to patients, which may significantly impact a patient's quality of life. As conventional treatments have only a transient therapeutic effect and result in unwanted side effects, many patients have attempted to find therapeutic herbs or compounds that function as safer and more potent treatments for alopecia. Many such herbs have been used in complementary and alternative medicine (CAM) for centuries; however, there is a lack of information on the therapeutic mechanisms of herbs used for the treatment of alopecia. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112907DOI Listing

Proton pump inhibitors are associated with increased risk of alopecia areata: A nationwide nested case-control study.

J Am Acad Dermatol 2020 Apr 28. Epub 2020 Apr 28.

School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.02.076DOI Listing
April 2020
4.449 Impact Factor

IL12B and IL23R polymorphisms are associated with alopecia areata.

Genes Immun 2020 May 1;21(3):203-210. Epub 2020 May 1.

Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Alopecia areata is an autoimmune disease in which activation of autoreactive T cells and inflammatory immune signals target the hair follicles autoantigens. Although cytokines are involved in regulating autoimmune inflammation, the specific involvement of these molecules in the pathogenesis of alopecia areata has been remained unsettled. Here, a possible influence of IL12B, IL17A, and IL23R variations on susceptibility to alopecia areata in Iranian patients was investigated. Read More

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http://dx.doi.org/10.1038/s41435-020-0100-1DOI Listing

Identification and verification of EOMEs regulated network in Alopecia areata.

Int Immunopharmacol 2020 Apr 27;84:106544. Epub 2020 Apr 27.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Alopecia areata (AA) is a common alopecia characterized by non-scarring hair loss with the dysregulated immunity. However, the pathogenesis of AA remains to be elucidated. In this study, we identified gene signatures and then analyzed transcription factor-immune regulatory network in AA using integrated bioinformatics methods. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106544DOI Listing

Pediatric alopecia areata.

Curr Pediatr Rev 2020 Apr 29. Epub 2020 Apr 29.

Department of Pediatrics and Department of Dermatology and Skin Sciences University of British Columbia, Vancouver, British Columbia. Canada.

Background: Alopecia areata (AA) is a non-scarring hair loss disorder of autoimmune etiology.

Objective: To familiarize physicians with the clinical presentation, diagnosis, evaluation, and management of pediatric alopecia areata.

Methods: The search term 'Alopecia areata' was entered into a Pubmed search. Read More

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http://dx.doi.org/10.2174/1573396316666200430084825DOI Listing

Topical methotrexate 1% gel for the treatment of localized alopecia areata.

Int J Dermatol 2020 Apr 28. Epub 2020 Apr 28.

All India Institute of Medical Sciences, Raipur, India.

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http://dx.doi.org/10.1111/ijd.14898DOI Listing

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study.

Dermatol Ther (Heidelb) 2020 Jun 27;10(3):515-521. Epub 2020 Apr 27.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Conca 71 Street, Ancona, Italy.

Introduction: Alopecia areata (AA) is a chronic inflammatory non-scarring type of hair loss. Current therapies for alopecia areata are rather limited and mainly involve the use of topical, intra-lesional or systemic steroids and topical immunotherapy, with variable benefit. Recent studies have demonstrated that vitamin D analogues could potentially promote hair growth in patients with patchy AA. Read More

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http://dx.doi.org/10.1007/s13555-020-00379-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211771PMC

Percentage of scalp-hair loss as a primary endpoint in alopecia areata trials.

Authors:
C Blome

Br J Dermatol 2020 Apr 27. Epub 2020 Apr 27.

Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Martinistraβe 52, 20246, Hamburg, Germany.

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http://dx.doi.org/10.1111/bjd.19045DOI Listing

Alopecia areata not due by isotretinoin. A thought in COVID-19 time.

Dermatol Ther 2020 Apr 22:e13451. Epub 2020 Apr 22.

Dermatology unit, Clínica Dermatológica Internacional, Madrid, Spain.

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http://dx.doi.org/10.1111/dth.13451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235497PMC

New and Emerging Therapies for Alopecia Areata.

Drugs 2020 May;80(7):635-646

Department of Dermatology, University of California-Irvine, 843 Health Sciences Road, Suite 1001, Irvine, CA, 92697, USA.

Alopecia areata (AA) is an autoimmune condition that affects up to 2% of the general population. Currently available treatment options for AA are of limited efficacy and can be associated with adverse effects. The advancement in understanding of the genetic and molecular mechanisms of AA has led to the development of novel treatment options, with the Janus kinase (JAK) inhibitor class of drugs at the forefront of ongoing clinical trials. Read More

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http://dx.doi.org/10.1007/s40265-020-01293-0DOI Listing

Collapse and Restoration of Hair Follicle Immune Privilege Ex Vivo: A Model for Alopecia Areata.

Methods Mol Biol 2020 ;2154:133-141

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

Alopecia areata (AA) is a hair follicle (HF) autoimmune disease leading to hair loss. Interferon gamma (IFNγ) is regarded as the key cytokine involved in AA development, which has been shown to play a role in the collapse of HF immune privilege (IP), CD8 T-cell-driven inflammation toward the HF bulb, and premature catagen development. We present here the procedure to induce IP collapse in human healthy HFs ex vivo. Read More

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http://dx.doi.org/10.1007/978-1-0716-0648-3_11DOI Listing
January 2020

Nonsurgical Induction of Alopecia Areata in C3H/HeJ Mice via Adoptive Transfer of Cultured Lymphoid Cells.

Methods Mol Biol 2020 ;2154:121-131

Centre for Skin Sciences, University of Bradford, Bradford, UK.

Surgical induction of alopecia areata (AA) via full-thickness grafting of spontaneous AA-affected C3H/HeJ mouse skin to naïve recipients has been a primary method of transferring the AA disease model phenotype. However, this method is associated with the need to perform an invasive procedure that could negatively impact animal wellbeing. Therefore, a rodent model that rapidly develops AA at a predictable rate and without the need to perform invasive surgical procedures on the mice is essential for studying the pathogenesis of AA. Read More

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http://dx.doi.org/10.1007/978-1-0716-0648-3_10DOI Listing
January 2020

Alopecia areata development in atopic dermatitis patients treated with dupilumab.

J Eur Acad Dermatol Venereol 2020 Apr 20. Epub 2020 Apr 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1111/jdv.16493DOI Listing

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Compound Glycyrrhizin Capsules Combined with a Topical Corticosteroid in Adults with Chronic Eczema.

Evid Based Complement Alternat Med 2020 30;2020:6127327. Epub 2020 Mar 30.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: Glycyrrhizin is widely used in skin disorders, such as psoriasis, alopecia areata, and allergic diseases, but has not been extensively studied in patients with chronic eczema.

Objective: To evaluate the efficacy and safety of oral compound glycyrrhizin (OCG) plus topical corticosteroid (TCS) in adults with chronic eczema.

Methods: This was a multicenter, randomized, double-blind, placebo-controlled study in patients with chronic eczema ( = 199). Read More

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http://dx.doi.org/10.1155/2020/6127327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149328PMC
March 2020
1.880 Impact Factor

Serum levels of interleukin-17 and 23 in patients with alopecia areata: a systematic review and meta-analysis.

Eur J Dermatol 2020 Apr 13. Epub 2020 Apr 13.

Department of Dermatology, Taipei Medical University Hospital,, Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1684/ejd.2020.3742DOI Listing

Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib.

Acta Derm Venereol 2020 May 28;100(10):adv00144. Epub 2020 May 28.

Department of Dermatology and Allergy, University Hospital Bonn, Venusberg-Campus 1, DE-53127 Bonn, Germany.

is missing (Short communication). Read More

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http://dx.doi.org/10.2340/00015555-3481DOI Listing

Partner bereavement and risk of chronic urticaria, alopecia areata and vitiligo: cohort studies in the United Kingdom and Denmark.

Br J Dermatol 2020 Apr 13. Epub 2020 Apr 13.

Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

The pathogeneses of skin diseases are not fully understood. Psychological stress has been proposed to be associated with skin diseases, but the epidemiological evidence is limited [1, 2]. We have recently reported the associations between partner bereavement (an extreme life stressor) and psoriasis, atopic eczema and melanoma [3, 4]. Read More

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http://dx.doi.org/10.1111/bjd.19122DOI Listing
April 2020
4.275 Impact Factor

Apremilast for extensive and treatment-resistant alopecia areata: a retrospective analysis of five patients.

Eur J Dermatol 2020 Apr 10. Epub 2020 Apr 10.

Department of Dermatology, Medical University of Vienna, Austria.

Background: Recent experimental data suggest a role for apremilast in the treatment of alopecia areata. Small clinical studies have so far provided contradictory results.

Objectives: We retrospectively evaluated the efficacy and safety of apremilast in five cases of extensive and treatment-resistant alopecia areata. Read More

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http://dx.doi.org/10.1684/ejd.2020.3749DOI Listing

Protein tyrosine phosphatase nonreceptor type 22 gene polymorphism in alopecia areata: Does it have an association with disease severity?

J Cosmet Dermatol 2020 Apr 12. Epub 2020 Apr 12.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.

Background: Alopecia areata is a condition involving hair loss from certain or all areas of the body. It has been considered as an immune-mediated disease, characterized by the infiltration of CD4+ and CD8+ lymphocytes in the hair follicles.

Aim Of The Study: The study aimed to assess whether protein tyrosine phosphatase nonreceptor type 22 gene single nucleotide polymorphism 1858C/T has any relationship with alopecia areata in Egyptian patients and whether it is associated with disease severity or not. Read More

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http://dx.doi.org/10.1111/jocd.13412DOI Listing

Eosinophilic folliculitis of the scalp associated with PD-1/PDL1 inhibitors.

J Cosmet Dermatol 2020 Apr 12. Epub 2020 Apr 12.

Department of Ematology, Oncology and Dermatology, "Sapienza" University of Rome, Rome, Italy.

Background: Immune checkpoint inhibitors are monoclonal antibodies which target immune "checkpoints" enhancing T cell-mediated cytotoxic and antitumor responses. Together to the amazing results, these drugs are associated with some peculiar adverse events called immune-related adverse events. Alopecia is one of these. Read More

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http://dx.doi.org/10.1111/jocd.13388DOI Listing

A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States.

Clin Cosmet Investig Dermatol 2020 1;13:259-266. Epub 2020 Apr 1.

Pfizer Inc., Cambridge, MA 02139, USA.

Purpose: Alopecia areata (AA) is an autoimmune disease characterized by the development of non-scarring alopecia. The prevalence is not well known, and estimates vary considerably with no recent estimates in the United States (US). The objective of this study was to define the current AA point prevalence estimate among the general population in the US overall and by severity. Read More

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http://dx.doi.org/10.2147/CCID.S245649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131990PMC

Efficacy of Postbiotics in a PRP-Like Cosmetic Product for the Treatment of Alopecia Area Celsi: A Randomized Double-Blinded Parallel-Group Study.

Dermatol Ther (Heidelb) 2020 Jun 11;10(3):483-493. Epub 2020 Apr 11.

Human Advanced Microbiome Project (HMAP), Giuliani SpA, Milan, Italy.

Introduction: Alopecia areata (AA), also known as 'area Celsi', is the second most common form of hair loss affecting the scalp. Newly proposed treatments for AA include low-level light therapy, biologics such as Janus kinase inhibitors and autologous platelet-rich plasma (PRP), which is a well-known "elixir" for hair growth. Bioactive peptides developed through biotechnological applications have been used to overcome the limitations of PRP. Read More

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http://dx.doi.org/10.1007/s13555-020-00369-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211773PMC

Putative therapeutic mechanisms of simvastatin in the treatment of alopecia areata.

J Am Acad Dermatol 2020 Apr 9. Epub 2020 Apr 9.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea; Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.03.102DOI Listing