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    3873 results match your criteria Alopecia Areata

    1 OF 78

    Traction alopecia: the root of the problem.
    Clin Cosmet Investig Dermatol 2018 6;11:149-159. Epub 2018 Apr 6.
    Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.
    Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. Read More

    Nail involvement in patients with moderate to severe alopecia areata treated with oral tofacitinib.
    J Dermatolog Treat 2018 Apr 16:1-18. Epub 2018 Apr 16.
    a Department of Dermatology , SMG-SNU Boramae Medical Center , Seoul , Korea.
    Background: A few anecdotal case reports demonstrated that tofacitinib improved nail changes associated with AA.

    Objective: To investigate nail changes in patients with AA treated with tofacitinib and evaluate the relationship between nail and hair responses to tofacitinib.

    Methods: This is a retrospective study of 33 adult patients with moderate-to-severe AA treated with oral tofacitinib monotherapy for at least 4 months. Read More

    Acta Pol Pharm 2016 Nov;73(6):1455-1460
    Diphenylcyclopropenone (DCP) is a topically administered agent used for more than three decades for treatment of alopecia areata (AA). Moreover, numerous recent studies show it's efficiency in treatment of cutaneous metastatic melanoma. Despite being a potentially useful drug still very little is known about the pharmacokinetics of DCP. Read More

    Increased prevalence of vitamin D deficiency in patients with alopecia areata: A systematic review and meta-analysis.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Republic.
    Background: Alopecia areata (AA) is a hair follicle-specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency. Read More

    Acta Pol Pharm 2017 Mar;74(2):459-464
    The aim of this study was to evaluate the chemical stability of diphenylcyclopropenone (DCP) in var- ious solvents. DCP is being used in topical therapy in patients with alopecia areata (AA). The solvents for DCP used so far were acetone, ethanol and propylene glycol. Read More

    Can the Cytokine Analysis of the Scales on Alopecic Patch Predict the Response to Diphenylcyclopropenone Treatment in Alopecia Areata Patients?
    Ann Dermatol 2018 Apr 21;30(2):150-157. Epub 2018 Feb 21.
    Department of Dermatology, Inha University School of Medicine, Incheon, Korea.
    Background: Contact immune modulating therapy with diphenylcyclopropenone (DPCP) is a topical treatment option for extensive alopecia areata (AA). Because the response to DPCP treatment varies according to the patient, and it takes several months to evaluate the clinical effectiveness of the treatment, it is necessary to identify the factors that can predict the prognosis of the disease while treating with topical DPCP.

    Objective: In this study, cytokine levels in the scales of alopecic patches were investigated to identify whether they could predict response to DPCP during the early treatment period. Read More

    Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression.
    Int J Dermatol 2018 Mar 30. Epub 2018 Mar 30.
    Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: Folliculotropic mycosis fungoides (FMF) is a cutaneous T-cell lymphoma mainly affecting the hair follicle, which seems to represent a place of immune privilege phenomenon.

    Objectives: To explore a possible role of immune privilege (IP) in FMF analyzing the major histocompatibility complex (MHC) expression.

    Methods: Immunohistochemistry for HLA-G and MHC-II was performed to formalin-fixed paraffin-embedded cutaneous skin biopsies of FMF patients (n = 43), conventional mycosis fungoides (CMF; n = 13), alopecia areata (AA; n = 13), and normal scalp skin (NS; n = 12). Read More

    Serum and tissue angiotensin-converting enzyme in patients with alopecia areata.
    Indian J Dermatol Venereol Leprol 2018 Mar 27. Epub 2018 Mar 27.
    Autoimmune Bullous Diseases Research Centre, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Alopecia areata is an immune-dependent disorder characterized by the interaction of T-lymphocytes with follicular antigens. Recent studies have shown the existence of a local renin-angiotensin system in the skin, where angiotensin-converting enzyme (ACE) plays a role in autoimmunity and inflammation.

    Aim: The objective of this study was to evaluate serum and tissue ACE activity in patients with alopecia areata. Read More

    Cancer risk in patients with alopecia areata: a nationwide population-based matched cohort study.
    Cancer Med 2018 Mar 25. Epub 2018 Mar 25.
    Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
    Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. Read More

    Regulatory T cells in autoimmune skin diseases.
    Exp Dermatol 2018 Mar 25. Epub 2018 Mar 25.
    Department of Dermatology, Hokkaido University Graduate School of Medicine.
    CD4 Foxp3 regulatory T cells (Tregs) are suppressors of immune activation and play a crucial role in the maintenance of peripheral tolerance. Mutations of Foxp3 result in fatal autoimmunity in multiple organs, including the skin, in both humans and mice. Many studies have demonstrated the altered frequency and functions of Tregs, changes in cytokine and chemokine levels related to Tregs, and the differences in genetic background regarding Tregs in autoimmune skin disorders. Read More

    Alopecia areata treated with hydroxychloroquine: A retrospective study of nine pediatric cases.
    Pediatr Dermatol 2018 Mar 25. Epub 2018 Mar 25.
    Division of Dermatology, University of Chicago Medicine, Chicago, IL, USA.
    Background/objectives: Alopecia areata is a common hair loss condition that is often emotionally devastating for patients. There is a paucity of effective treatments available. Hydroxychloroquine has been reported as variably effective in inducing significant hair regrowth in adults with alopecia areata. Read More

    Sex- and age-adjusted prevalence estimates of five chronic inflammatory skin diseases in France: results of the « OBJECTIFS PEAU » study.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    Société Française de Dermatologie (SFD), Paris, France.
    Background: There are few population-based studies assessing the prevalence of skin diseases.

    Objectives: To estimate the prevalence of five chronic skin inflammatory diseases, i.e. Read More

    Trichoscopy of alopecia areata: An update.
    J Dermatol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    The diagnosis of alopecia areata is usually based on clinical manifestations. However, there are several hair and scalp disorders that share similar clinical features with alopecia areata, such as tinea capitis, trichotillomania or traction alopecia. Trichoscopy as a fast, non-invasive and easy-to-perform technique may help to identify subtle details and establish the correct diagnosis. Read More

    Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down's syndrome.
    Ital J Pediatr 2018 Mar 21;44(1):39. Epub 2018 Mar 21.
    Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.
    Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down's syndrome (DS). According to recent reports, DS children are, per se, more exposed to the risk of both Hashimoto's thyroiditis (HT) and Graves' disease (GD), irrespective of other concomitant risk factors, such as female gender and family antecedents for AITDs. In the context of extra-thyroidal autoimmune disorders, the ones that preferentially aggregate with AITDs in DS children are alopecia areata and vitiligo. Read More

    Alopecia areata is a medical disease.
    J Am Acad Dermatol 2018 Apr;78(4):832-834
    Department of Dermatology, University of California Irvine, Irvine, California; National Alopecia Areata Foundation, San Rafael, California. Electronic address:

    Intramuscular Steroids in the Treatment of Dermatologic Disease: A Systematic Review.
    J Drugs Dermatol 2018 Mar;17(3):323-329
    Importance: Intramuscular (IM) steroids can be used to treat a wide variety of dermatologic diseases. Although seemingly effective and safe, this form of corticosteroid therapy may be underused amongst dermatologists.

    Objective: The objective of this review is to determine the evidence regarding the efficacy and side effect profile of intramuscular triamcinolone in the treatment of dermatologic disease. Read More

    IL-17 inhibition: is it the long-awaited savior for alopecia areata?
    Arch Dermatol Res 2018 Mar 1. Epub 2018 Mar 1.
    International Hair Research Foundation (IHRF), Milan, Italy.
    Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available information on the connection between AA and IL-17 is described. Read More

    Association of alopecia areata with atopic dermatitis and chronic spontaneous urticaria.
    Allergy Asthma Proc 2018 Mar;39(2):96-102
    From the Leumit Health Services, Tel-Aviv, Israel.
    Background: Epidemiologic studies report that alopecia areata (AA) is related to various atopic and autoimmune diseases. The purpose of this study was to identify clinical characteristics and the prevalence of comorbid conditions in Israeli patients with AA.

    Methods: This retrospective, matched, case-control study was based on data from an electronic patient record data base. Read More

    Diphencyclopropenone (DPCP) for alopecia areata: a UK survey.
    Br J Dermatol 2018 Feb 26. Epub 2018 Feb 26.
    Department of Dermatology, Solihull Hospital, Heart of England NHS Foundation Trust, Lode Lane, B91 2JL, U.K.
    Alopecia areata (AA) is a T-cell mediated autoimmune hair loss condition with an estimated lifetime risk of 1.7%. It is characterized clinically by sudden-onset non-inflammatory hair loss that may occur at any site. Read More

    Alopecia universalis unresponsive to treatment with tofacinitib: report of a case with a brief review of the literature.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Marmara University School of Medicine, Department of Dermatology, Istanbul, Turkey.
    Janus kinase inhibitors are emerging treatment alternatives in various immune-mediated diseases including alopecia universalis. Herein, we report a patient with psoriasis and alopecia universalis in whom treatment with tofacitinib led to remission of psoriasis without improvement in alopecia universalis. Despite the promising potential in alopecia areata treatment, research evaluating the efficacy of different Janus kinase inhibitors and possible prognostic factors related with a more favorable response are warranted. Read More

    Adalimumab-related alopecia in a patient affected by psoriasis.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Department of Dermatology, Hospital Universitari Sagrat Cor, Barcelona, Spain.
    Alopecia induced by biological therapy is a rare side effect of this type of drugs. A total of 23 patients of psoriasiform eruptions with severe scalp involvement that induced alopecia during anti-tumor necrosis factor (anti-TNF) treatment of non-dermatological conditions have been previously reported. We present a 50-year-old man affected by plaque psoriasis that developed psoriasiform patches with alopecia over his scalp 10 months after initiating treatment with adalimumab. Read More

    Emerging drugs for alopecia areata: JAK inhibitors.
    Expert Opin Emerg Drugs 2018 Mar 26;23(1):77-81. Epub 2018 Feb 26.
    b Fredric Brandt Endowed Professor of Dermatology - Miller School of Medicine , University of Miami , Miami , FL , USA.
    Introduction: Alopecia Areata is a common form of non-scarring hair loss that usually starts abruptly with a very high psychological impact. Due to the still not completely understood etiopathogenesis, at present there is no treatment that can induce a permanent remission and there is no drug approved for the treatment of this disorder. Areas covered: Leading existing treatment are briefly overviewed and then ongoing research on Janus Kinases Inhibitors is discussed, reviewing trials with oral and topical formulations so as new opportunities for other forms of alopecia, such as cicatricial alopecia. Read More

    Study of the efficacy of carboxytherapy in alopecia.
    J Cosmet Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Background: Management of alopecia areata (AA) and androgenetic alopecia (AGA) is often challenging. The use of carboxytherapy may be a novel therapeutic option for such cases.

    Objective: To evaluate the clinical efficacy and safety of carboxytherapy in alopecia areata and androgenetic alopecia. Read More

    An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis.
    J Invest Dermatol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Columbia University, New York, New York, USA. Electronic address:
    Alopecia areata (AA) is a common autoimmune disease with a lifetime risk of ∼2%. In AA, the immune system targets the hair follicle, resulting in clinical hair loss. The prognosis of AA is unpredictable, and currently there is no definitive treatment. Read More

    Use of an Alternating Inflatable Head Pad inPatients Undergoing Open Heart Surgery.
    Med Sci Monit 2018 Feb 16;24:970-976. Epub 2018 Feb 16.
    Department of Nursing, Yantai Yuhuangding Hospital, Yantai, Shandong, China (mainland).
    BACKGROUND Preoperative symptoms like occipital pressure ulcers and alopecia areata (AA) significantly lowered patient quality of life. Therefore, preoperative nursing was in need of investigation. This study aimed to compare effects of an alternating inflatable head pad and a gel pad on occurrence of postoperative pressure ulcers and AA in patients undergoing open heart surgery. Read More

    Topical Immunotherapy of Alopecia Areata: A Large Retrospective Study.
    Dermatol Ther (Heidelb) 2018 Mar 13;8(1):101-110. Epub 2018 Feb 13.
    Dermatology Department of Centro Medico Polispecialistico, Pavia, Italy.
    Introduction: Topical immunotherapy is frequently used in the treatment of alopecia areata (AA) although few studies report long-term follow-up. Our goals were to determine the efficacy and the prognostic factors of topical immunotherapy in a large cohort of patients with AA treated in the departments of Dermatology and Venereology of Bergamo, Como and Pavia, from 1978 to January 2016.

    Methods: A total of 252 patients with AA were evaluated retrospectively. Read More

    Three Cases of Radiation-induced Temporary Alopecia with Hair Microscopic Examination: "Coudability Hair" Might Not be Specific for Alopecia Areata.
    Int J Trichology 2018 Jan-Feb;10(1):40-43
    Department of Dermatology, Busan Paik Hospital, Busan, Korea.
    Endovascular interventional procedures are widely used for the treatment of intracranial vascular lesions. However, they sometimes produce reversible alopecia, known as radiation-induced temporary alopecia, depending on the radiation dose. Radiation-induced temporary alopecia manifested as rectangular alopecic patches without signs of inflammation, reflects damage to the keratinocytes in the hair matrix of anagen hair follicles, due to the sensitivity of these cells to radiation. Read More

    Annular Alopecia Areata: A Morphologically Rare Variant.
    Int J Trichology 2018 Jan-Feb;10(1):34-36
    Department of Dermatology and Venereology, Government Medical College and Hospital, Chandigarh, India.
    Alopecia areata (AA) is the most common form of nonscarring alopecia involving the scalp and/or body. The most common pattern of hair loss is oval or round, but newer morphological variants are increasingly being described. We hereby report two cases of annular pattern of AA due to its unusual morphology. Read More

    Development of Frontal Fibrosing Alopecia with a History of Alopecia Areata.
    Int J Trichology 2018 Jan-Feb;10(1):29-30
    Department of Dermatology, University of California, Irvine, Irvine, California.
    Frontal fibrosing alopecia (FFA), a scarring type of alopecia, developed in two patients with a history of alopecia areata (AA). Both patients had biopsies to confirm this interesting series of pathology. Etiology and pathogenesis of this AA-to-FFA sequence will be discussed. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    Impact of climate change on dermatological conditions related to flooding: update from the International Society of Dermatology Climate Change Committee.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Department of Dermatology, Mayo Clinic in Minnesota, Rochester, Minnesota, USA.
    Climate change contributes to the increase in severity and frequency of flooding, which is the most frequent and deadly disaster worldwide. Flood-related damage can be very severe and include health effects. Among those health impacts, dermatological diseases are one of the most frequently encountered. Read More

    Applying the Common Sense Model to predicting quality of life in alopecia areata: The role of illness perceptions and coping strategies.
    J Health Psychol 2018 Jan 1:1359105317752826. Epub 2018 Jan 1.
    Leiden University, The Netherlands.
    Applying the Common Sense Model, this cross-sectional study examines associations between illness perceptions and quality of life and the mediating role of coping in 243 adults with alopecia areata, a chronic dermatological condition. At least some QoL impairment was reported by 84 percent of participants, with 31 percent reporting very to extremely large impairment. Stronger perceptions of consequences, emotional representations, identity, and lower attribution to chance were related to more impairment, with avoidant coping acting as (partial) mediator. Read More

    Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata.
    J Clin Lab Anal 2018 Jan 18. Epub 2018 Jan 18.
    Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, Tokat, Turkey.
    Background: Alopecia areata (AA), which appears as nonscarring hair shedding on any hair-bearing area, is a common organ-specific autoimmune condition. Cytokines have important roles in the development of AA. Interleukin (IL) 18 is a significant proinflammatory cytokine that was found higher in the patients with AA. Read More

    Is there an association of ABO blood groups and Rhesus factor with alopecia areata?
    J Cosmet Dermatol 2018 Jan 15. Epub 2018 Jan 15.
    Department of Dermatology, Faculty of Medicine, Selcuk University, Konya, Turkey.
    Background/objectives: Alopecia areata (AA) is an autoimmune disease characterized by noncicatricial hair loss localized on hair, beard, mustache, eyebrow, eyelash, and sometimes on the body. Although etiopathogenesis is not fully understood, many studies show remarkable associations between various diseases and ABO blood groups. However, there is no study with AA and blood groups. Read More

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