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    1 OF 76

    Yellow dots in trichoscopy: relevance, clinical significance and peculiarities.
    An Bras Dermatol 2017 Sep-Oct;92(5):724-726
    Alopecia Outpatient Clinic at Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.
    Yellow dots are follicular ostium filled with keratin and/or sebum. Initially, they were exclusively associated with alopecia areata. Currently they have also been described in androgenetic alopecia, chronic cutaneous (discoid) lupus erythematosus, and dissecting cellulitis. Read More

    Alopecia Universalis following Alemtuzumab Treatment in Multiple Sclerosis: A Barely Recognized Manifestation of Secondary Autoimmunity-Report of a Case and Review of the Literature.
    Front Neurol 2017 30;8:569. Epub 2017 Oct 30.
    Department of Neurology, Universitätsklinikum Bonn, Bonn, Germany.
    Secondary autoimmunity is the most frequent adverse event occurring in almost every other alemtuzumab-treated multiple sclerosis patient. We report a case of a patient with relapsing-remitting multiple sclerosis who reported smooth, circular areas of complete hair loss on both thighs 6 months after the second treatment cycle with alemtuzumab. The patient was diagnosed as having alopecia areata (AA). Read More

    Novel Therapies For Alopecia Areata: The Era Of Rational Drug Development.
    J Allergy Clin Immunol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology, Columbia University. Electronic address:
    The treatments for Alopecia Areata (AA) have evolved over the decades from broad and non-specific therapies, to those that are now more targeted and rationally selected. This was achieved by close co-operation and communication between clinicians and basic scientists, which resulted in the elucidation and understanding of the unique pathophysiology of AA. In this review, we discuss this evolution, and how novel therapies for AA has changed over the decades, what we have in our current arsenal of drugs for this potentially devastating disease, and what the future holds. Read More

    Unilesional Follicular Mycosis Fungoides: Report of 6 Cases and Review of the Literature.
    Am J Dermatopathol 2017 Oct 24. Epub 2017 Oct 24.
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Division of Dermatology, Memorial Hospital of Rhode Island, The Warren Alpert Medical School of Brown University, Providence, RI; and ‡Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
    Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion. All the patients had the lesions for at least a few months. Read More

    Objective Outcome Measures: Collecting Meaningful Data on Alopecia Areata.
    J Am Acad Dermatol 2017 Nov 8. Epub 2017 Nov 8.
    University of Minnesota, Minneapolis, MN.
    Background: Although alopecia areata is a common disorder, it has no FDA approved treatment and evidence-based therapeutic data is lacking.

    Objective: To develop guidelines for the diagnosis, evaluation, assessment, response criteria and endpoints for alopecia areata.

    Methods: Literature review and expert opinion of a group of dermatologists specializing in hair disorders. Read More

    Utilization of Mental Health Resources and Complementary and Alternative Therapies for Alopecia Areata: A U.S. Survey.
    Int J Trichology 2017 Oct-Dec;9(4):160-164
    Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
    Background: The efficacy of traditional medical treatments for alopecia areata (AA) is limited, leading some to pursue alternative treatments. The utilization and nature of these treatments are unclear.

    Objective: To assess the extent to which patients with AA pursue alternative treatments and to characterize these treatments. Read More

    Detection of Tumor Necrosis Factor-alpha in Nonlesional Tissues of Alopecia Areata Patients: A Prove for a Systemic Disease.
    Int J Trichology 2017 Oct-Dec;9(4):154-159
    Department of Biochemistry, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt.
    Introduction: The pathogenesis of alopecia areata (AA) remains incompletely understood. Different cytokines may play a role in AA. Tumor necrosis factor-alpha (TNF-α) has been shown to be inhibitory to hair follicle growth in in vitro studies suggesting that it may play an important role in AA. Read More

    Insignificant Correlation between Thyroid Hormone and Antithyroid Peroxidase Antibodies in Alopecia Areata Patients in Northern Rajasthan.
    Int J Trichology 2017 Oct-Dec;9(4):149-153
    Department of Dermatology, STDs and Leprosy, SMS Medical College, Jaipur, Rajasthan, India.
    Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0. Read More

    Subclinical Sensitization with Diphenylcyclopropenone is Sufficient for the Treatment of Alopecia Areata: Retrospective Analysis of 159 Cases.
    J Am Acad Dermatol 2017 Nov 3. Epub 2017 Nov 3.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea. Electronic address:
    Background: Contact immunotherapy with diphenylcyclopropenone (DPCP) is presently considered the treatment of choice for extensive alopecia areata (AA). However, a major concern with contact immunotherapy is that it causes various adverse effects (AEs) that contribute to discontinuation of treatment.

    Objective: We investigated whether a modified DPCP treatment protocol can promote hair regrowth with fewer AEs. Read More

    Pediatric severity of alopecia tool.
    Pediatr Dermatol 2017 Nov 6. Epub 2017 Nov 6.
    Division of Pediatrics, Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    The Severity of Alopecia Tool serves as a tool for alopecia research and a clinical guideline for following progression of disease. The original Severity of Alopecia Tool score does not take into account pediatric age groups. As new clinical trials for alopecia areata include more children, a more accurate tool should be available for this population. Read More

    An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata.
    J Invest Dermatol 2017 Nov 3. Epub 2017 Nov 3.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:
    Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Read More

    Alopecia Areata. Current situation and perspectives.
    Arch Argent Pediatr 2017 Dec;115(6):e404-e411
    Centro Dermatológico Brunnenhalt de Reynosa, Reynosa, Tamaulipas, México.
    Alopecia areata (AA) is a dermatological disease characterized by non-scarring hair loss of the scalp and/or body, with an unpredictable and variable evolution in the patients in which, despite multidisciplinary efforts, its etiology is not entirely known, although some evidence suggests that environmental, immunological and genetic factors could be generating the disease. The aim of this review is to provide an updated panorama of the clinical characteristics, diagnosis and treatment of AA, to analyze the mechanisms that could participate in its etiology, as well as to review some of the most important genetic variants that could confer susceptibility to the development of this disease. Read More

    Syphilitic alopecia: uncommon trichoscopic findings.
    Dermatol Pract Concept 2017 Jul 31;7(3):55-59. Epub 2017 Jul 31.
    Dermatology Unit, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena, Italy.
    Syphilitic alopecia (SA) is considered an uncommon manifestation of secondary syphilis. SA can present in a diffuse form, resembling telogen effluvium, or in a moth-eaten form that mimics a variety of conditions (i.e. Read More

    Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell subsets in AA vs. Read More

    Genome-wide microRNA analysis implicates miR-30b/d in the etiology of alopecia areata.
    J Invest Dermatol 2017 Oct 25. Epub 2017 Oct 25.
    Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. Electronic address:
    Alopecia areata (AA) is one of the most common forms of human hair loss. Although genetic studies have implicated autoimmune processes in AA etiology, understanding of the etiopathogenesis is incomplete. Recent research has implicated microRNAs, a class of small non-coding RNAs, in diverse autoimmune diseases. Read More

    Is there a relationship between melanocytes and sensorineural hearing loss? Clinical evaluation of 51 patients with alopecia areata.
    Clin Otolaryngol 2017 Oct 17. Epub 2017 Oct 17.
    Department of Otorhinolaryngology-Head and Neck Surgery, Bakırköy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

    Lupus-like cutaneous reaction following pembrolizumab: An immune-related adverse event associated with anti-PD-1 therapy.
    J Cutan Pathol 2017 Oct 13. Epub 2017 Oct 13.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy. Read More

    Association Khellin and 308-nm Excimer lamp in the treatment of severe alopecia areata in a child.
    J Cosmet Laser Ther 2017 Oct 11. Epub 2017 Oct 11.
    a Department of Dermatology , Habib Thameur Hospital , Tunis , Tunisia.
    Alopecia areata (AA) is an autoimmune inflammatory disorder of hair, characterized by non-scarring hair loss. 308-nm Excimer lamp (EL) has been reported as one effective modality in the treatment of AA. Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with UVA. Read More

    Vitamin D and the Skin: An Update for Dermatologists.
    Am J Clin Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
    Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

    Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review.
    Clin Rev Allergy Immunol 2017 Dec;53(3):394-412
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland.
    Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. Read More

    Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling.
    Math Med Biol 2017 Aug 7. Epub 2017 Aug 7.
    Department of Mathematics, 208 Love Building, 1017 Academic Way, Florida State University, Tallahassee, FL 32306, USA.
    Alopecia areata (AA) is a CD8$^{+}$ T cell-dependent autoimmune disease that disrupts the constantly repeating cyclic transformations of hair follicles (HFs). Among the three main HF cycle stages-growth (anagen), regression (catagen) and relative quiescence (telogen)-only anagen HFs are attacked and thereby forced to prematurely enter into catagen, thus shortening active hair growth substantially. After having previously modelled the dynamics of immune system components critically involved in the disease development (Dobreva et al. Read More

    Screening Guidelines for Thyroid Function in Children With Alopecia Areata.
    JAMA Dermatol 2017 Sep 27. Epub 2017 Sep 27.
    Section of Pediatric Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Importance: The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied with no consensus on whether a true association with AA exists. In addition, screening practices for thyroid dysfunction in children with AA vary widely among clinicians.

    Objective: To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to to characterize thyroid function in children with AA to establish guidelines for screening. Read More

    Coexistence of eruptive syringoma and bilateral nipple vitiligo: Could there be a common immunopathogenesis?
    North Clin Istanb 2017 26;4(2):195-198. Epub 2017 Aug 26.
    Department of Pathology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
    The rarely seen eruptive syringoma (ES) is characterized by small, skin-colored, papules. Lesions are benign; however, treatment is often unsuccessful. Recent studies have a suggested role of the autoimmune response, rather than reactive proliferation of acrosyringium in the pathogenesis of ES. Read More

    Nail Involvement in Alopecia Areata: A Questionnaire-Based Survey of Impact on Quality of Life and Review of the Literature.
    Acta Derm Venereol 2017 Oct 2. Epub 2017 Oct 2.
    Department of Dermatology, Radboud University Nijmegen Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.
    Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes in patients with AA. Read More

    Factors Associated with Severity of Alopecia Areata.
    Ann Dermatol 2017 Oct 25;29(5):565-570. Epub 2017 Aug 25.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Background: Alopecia areata is the most common cause of localized, nonscarring alopecia. Unfortunately, there are few data regarding clinical features and epidemiology of alopecia areata in Korean patients, and its clinical course and treatment response rates are unpredictable.

    Objective: This study strived to investigate the differences in clinical profiles according to disease severity and to determine risk factors for severe alopecia areata. Read More

    Home-based contact immunotherapy with diphenylcyclopropenone for alopecia areata is as effective and safe as clinic-based treatment in patients with stable disease: A retrospective study of 40 patients.
    J Am Acad Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Electronic address:

    Hair Growth in Two Alopecia Patients after Fecal Microbiota Transplant.
    ACG Case Rep J 2017 13;4:e107. Epub 2017 Sep 13.
    Alpert Medical School, Brown University, Providence, RI.
    Clostridium difficile infections can be life-threatening but are increasingly being treated successfully with fecal microbiota transplantation (FMT). We report two patients with alopecia universalis who developed subsequent hair regrowth after FMT for treatment of recurrent C. difficile infections. Read More

    Hair Loss: Common Causes and Treatment.
    Am Fam Physician 2017 Sep;96(6):371-378
    Washington Health Systems Family Medicine Residency, Washington, PA, USA.
    Hair loss is often distressing and can have a significant effect on the patient's quality of life. Patients may present to their family physician first with diffuse or patchy hair loss. Scarring alopecia is best evaluated by a dermatologist. Read More

    Autoimmune diseases involving skin and intestinal mucosa are more frequent in adolescents and young adults suffering from atopic dermatitis.
    J Dermatol 2017 Sep 19. Epub 2017 Sep 19.
    Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
    Evidence has emerged about the relationship between atopic dermatitis (AD) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co-occurrence of AD and autoimmune diseases. Read More

    Distinct Patterns and Aetiology of Chromonychia.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 61469, Korea.
    Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20. Read More

    Shedding Light on Alopecia Areata in Pediatrics: A Retrospective Analysis of Comorbidities in Children in the National Alopecia Areata Registry.
    Pediatr Dermatol 2017 Sep;34(5):e271-e272
    Department of Dermatology, Columbia University, New York, New York.
    Alopecia areata (AA) is a common autoimmune disease and it is challenging to predict which patients will have severe disease. The purpose of this retrospective study was to identify comorbidities in children enrolled in the National Alopecia Areata Registry. Atopic dermatitis was more common in patients with severe AA than in those with mild disease. Read More

    Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients.
    Skin Appendage Disord 2017 Aug 22;3(3):156-160. Epub 2017 Apr 22.
    Center for Dermatology and Hair Diseases Professor Trüeb, Wallisellen, Switzerland.
    Background/aims: Alopecia areata is a common immune-mediated hair condition with limited treatment options and success rates. There is evidence that statins, which are used for reducing atherogenesis and cardiovascular disease, have immunomodulatory activities and therefore may also be used for treatment of selected dermatologic conditions, including alopecia areata. Among treatments evaluated for alopecia areata, oral simvastatin/ezetimibe therapy is currently under the scrutiny of expert opinion. Read More

    Bullying and Quality of Life in Pediatric Alopecia Areata.
    Skin Appendage Disord 2017 Aug 24;3(3):115-118. Epub 2017 Mar 24.
    Section of Pediatric Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
    Alopecia areata (AA) is a clinically heterogeneous disease that is characterized by nonscarring hair loss, nail changes, and increased risk of other autoimmune disease. During clinical visits, children with AA often report bullying. We report survey results that highlight the prevalence of bullying and surrounding emotional impact of AA in pediatric patients. Read More

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