JBI Evid Synth 2021 May 28. Epub 2021 May 28.
School of Nursing, University of São Paulo (EEUSP), São Paulo, Brazil Clinics Hospital of Faculty of Medicine, University of São Paulo - HCFMUSP, São Paulo, Brazil The Brazilian Centre for Evidence-based Healthcare: A JBI Centre of Excellence, São Paulo, Brazil.
Objective: This review will aim to synthesize the best available evidence on the effectiveness of leukocyte reduction comparing post-storage and pre-storage filters regarding transfusion reactions, bacterial infection, length of stay, and mortality.
Introduction: Transfusion is a relevant therapy, but it is not risk-free. Leukocyte reduction can be performed either by apheresis or by pre- or post-storage filters in order to reduce the risk of transfusion reactions, transmission of some diseases, alloimmunization, and platelet refractoriness, in addition to the length of stay and the use of antibiotics. Read More