488,362 results match your criteria Allergy asthma and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology[Journal]


Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases.

Int Arch Allergy Immunol 2020 Jul 8:1-12. Epub 2020 Jul 8.

Department of Clinical Immunology and Allergy Sechenov, First Moscow State Medical University, Moscow, Russian Federation.

Background: Interrelation between thyrocytes and immunocytes has been established. However, the roles of mast cells and thyroid hormones in the triggering mechanism of thyroid autoimmune processes have been insufficiently investigated. This study evaluated the role of thyroid hormones and mast cells in the mechanisms of losing tolerance to thyroid autoantigens. Read More

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http://dx.doi.org/10.1159/000508937DOI Listing

Metabolic Modulation of Immunity: A New Concept in Cancer Immunotherapy.

Cell Rep 2020 Jul;32(1):107848

Experimental & Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg; Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, Odense University Hospital, University of Southern Denmark, Odense, Denmark; Immunology and Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Belvaux, Luxembourg. Electronic address:

Immunotherapy shifted the paradigm of cancer treatment. The clinical approval of immune checkpoint blockade and adoptive cell transfer led to considerable success in several tumor types. However, for a significant number of patients, these therapies have proven ineffective. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107848DOI Listing

Pulmonary Microvascular- Changes in Adult Survivors of Prematurity: Utility of DCE MRI.

Am J Respir Crit Care Med 2020 Jul 8. Epub 2020 Jul 8.

University of Wisconsin, Madison, Wisconsin, United States;

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http://dx.doi.org/10.1164/rccm.202002-0344LEDOI Listing

Trends in CD4 and viral load testing 2005 to 2018: multi-cohort study of people living with HIV in Southern Africa.

J Int AIDS Soc 2020 Jul;23(7):e25546

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Introduction: The World Health Organization (WHO) recommends a CD4 cell count before starting antiretroviral therapy (ART) to detect advanced HIV disease, and routine viral load (VL) testing following ART initiation to detect treatment failure. Donor support for CD4 testing has declined to prioritize access to VL monitoring. We examined trends in CD4 and VL testing among adults (≥15 years of age) starting ART in Southern Africa. Read More

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http://dx.doi.org/10.1002/jia2.25546DOI Listing

Delays in repeat HIV viral load testing for those with elevated viral loads: a national perspective from South Africa.

J Int AIDS Soc 2020 Jul;23(7):e25542

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Introduction: In South Africa, HIV patients with an elevated viral load (VL) should receive repeat VL testing after adherence counselling. We set out to use a national HIV Cohort to describe time to repeat viral load testing across South Africa and identify predictors of time to repeat testing.

Methods: We conducted a cohort study of prospectively collected laboratory data. Read More

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http://dx.doi.org/10.1002/jia2.25542DOI Listing

Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran.

J Paediatr Child Health 2020 Jul 8. Epub 2020 Jul 8.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/jpc.15048DOI Listing

House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

Clin Exp Allergy 2020 Jul 8. Epub 2020 Jul 8.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Background: House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross-sectional and limited to a single exposure measurement.

Objective: We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age. Read More

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http://dx.doi.org/10.1111/cea.13705DOI Listing

Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort.

Allergy 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics, University of Cincinnati College of Medicine, 3230 Eden Avenue, Cincinnati, Ohio, 45267, USA.

Background: Atopic dermatitis (AD) patients are often colonized with Staphylococcus aureus and staphylococcal biofilms have been reported on adult AD skin lesions. The commensal Staphylococcus epidermidis can antagonize S. aureus, although its role in AD is unclear. Read More

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http://dx.doi.org/10.1111/all.14489DOI Listing

An expanded cell wall damage signaling network is comprised of the transcription factors Rlm1 and Sko1 in Candida albicans.

PLoS Genet 2020 Jul 8;16(7):e1008908. Epub 2020 Jul 8.

Department of Sciences, John Jay College of the City University of New York, New York, New York, United States of America.

The human fungal pathogen Candida albicans is constantly exposed to environmental challenges impacting the cell wall. Signaling pathways coordinate stress adaptation and are essential for commensalism and virulence. The transcription factors Sko1, Cas5, and Rlm1 control the response to cell wall stress caused by the antifungal drug caspofungin. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008908DOI Listing

Transcriptomic Modifications in Developmental Cardiopulmonary Adaptations to Chronic Hypoxia Using a Murine Model of Simulated High Altitude Exposure.

Am J Physiol Lung Cell Mol Physiol 2020 Jul 8. Epub 2020 Jul 8.

Indiana University Bloomington, United States.

Mechanisms driving adaptive developmental responses to chronic high altitude (HA) exposure are incompletely known. We developed a novel rat model mimicking the human condition of cardiopulmonary adaptation to HA starting at conception and spanning the in utero and post-natal timeframe. We assessed lung growth and cardiopulmonary structure and function, and performed transcriptome analyses to identify mechanisms facilitating developmental adaptations to chronic hypoxia. Read More

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http://dx.doi.org/10.1152/ajplung.00487.2019DOI Listing

Propensity score analysis of overall survival between first- and second-generation EGFR-TKIs using the Real-World Data.

Cancer Sci 2020 Jul 8. Epub 2020 Jul 8.

Department of Thoracic Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku Nagoya, Nagoya, Aichi, 464-8681, Japan.

We constructed a data set of EGFR-mutant NSCLC patients, and compared the overall survival of first-generation (1G), and second-generation (2G) EGFR-TKIs in clinical practice using propensity score. We reviewed the clinical data of consecutive EGFR-mutated NSCLC patients who received EGFR-TKI therapy between Jan 2008 and Aug 2017 at 11 institutions in Japan. The primary endpoint was OS. Read More

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http://dx.doi.org/10.1111/cas.14560DOI Listing

Tape-strips from early-onset pediatric atopic dermatitis highlight disease abnormalities in non-lesional skin.

Allergy 2020 Jul 8. Epub 2020 Jul 8.

Department of Dermatology and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Background: Skin biopsies promote our understanding of atopic dermatitis/AD pathomechanisms in infants/toddlers with early-onset AD, but are not feasible in pediatric populations. Tape-strips are an emerging, minimally-invasive alternative, but global transcriptomic profiling in early pediatric AD is lacking. We aimed to provide global lesional and non-lesional skin profiles of infants/toddlers with recent-onset, moderate-to-severe AD using tape-strips. Read More

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http://dx.doi.org/10.1111/all.14490DOI Listing

Update on asthma prevalence in severe COVID-19 patients.

Allergy 2020 Jul 8. Epub 2020 Jul 8.

Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany.

We carefully read the recently published research letter "Is asthma protective of COVID-19?" by Carli et al. with great interest. Important topics for asthma patients during the coronavirus disease 2019 (COVID-19) pandemic were discussed, including that until recently there was limited evidence that patients with chronic respiratory disorders are at lower risk of being infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or becoming severely ill. Read More

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http://dx.doi.org/10.1111/all.14482DOI Listing

Recent advances in diagnosis and management of irritable bowel syndrome.

Curr Opin Psychiatry 2020 Jul 6. Epub 2020 Jul 6.

Translational Research Centre for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.

Purpose Of Review: This review summarizes recent progress in the diagnosis and management of irritable bowel syndrome, with a focus on dietary and microbiota aspects.

Recent Findings: From a pathophysiological point of view, IBS is a multifactorial condition with both peripheral (transit) as central (visceral hypersensitivity, anxiety, depression) contribution in a cumulative fashion to the symptom pattern and severity. More recently, the focus has shifted to diet and microbiota. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000628DOI Listing

Adiponectin Levels Linked to Subclinical Myocardial Fibrosis in HIV.

J Acquir Immune Defic Syndr 2020 Jul 6. Epub 2020 Jul 6.

National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20814, USA.

Background: Persons living with HIV (PLWH) are at increased risk of myocardial dysfunction and metabolic disturbances represent one of several potential contributing factors. Adiponectin is an adipokine that enhances insulin sensitivity with potential cardioprotective effects. We therefore investigated the relationship between myocardial fibrosis, adiponectin and related metabolic parameters to better understand the pathophysiologic mechanisms of myocardial injury in PLWH. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002440DOI Listing

Training Chaplains to Provide Communication-Board-Guided Spiritual Care for Intensive Care Unit Patients.

J Palliat Med 2020 Jul 7. Epub 2020 Jul 7.

Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Chaplain-led communication-board-guided spiritual care may reduce anxiety and stress during an intensive care unit (ICU) admission for nonvocal mechanically ventilated patients, but clinical pastoral education does not teach the assistive communication skills needed to provide communication-board-guided spiritual care. To evaluate a four-hour chaplain-led seminar to educate chaplains about ICU patients' psychoemotional distress, and train them in assistive communication skills for providing chaplain-led communication-board-guided spiritual care. A survey immediately before and after the seminar, and one-year follow-up about use of communication-board-guided spiritual care. Read More

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http://dx.doi.org/10.1089/jpm.2020.0041DOI Listing

A clozapine-induced hypersensitivity reaction.

Ir J Psychol Med 2020 Jun 17;37(2):122-125. Epub 2017 Oct 17.

Department of Psychiatry, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland.

A 57-year-old female patient with a diagnosis of schizo-affective disorder since 1986 was commenced on clozapine due to persistent positive and negative psychotic symptoms in September 2014. After commencement of clozapine she was delusion free and demonstrated an improvement in negative symptoms. Three months after commencement of clozapine she developed a hypersensitivity reaction. Read More

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http://dx.doi.org/10.1017/ipm.2017.45DOI Listing

Management of Severe Asthma During the COVID-19 Pandemic in Korea.

Allergy Asthma Immunol Res 2020 Sep;12(5):897-901

Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Medical School, Jeonju, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.897DOI Listing
September 2020

Omalizumab Treatment in Patients With Cholinergic Urticaria: A Real-World Retrospective Study in Korea.

Allergy Asthma Immunol Res 2020 Sep;12(5):894-896

Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.894DOI Listing
September 2020

Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis.

Allergy Asthma Immunol Res 2020 Sep;12(5):885-893

Immunoallergology Unit, Careggi University Hospital, Florence, Italy.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.885DOI Listing
September 2020

Mitochondrial and Nuclear Mitochondrial Variants in Allergic Diseases.

Allergy Asthma Immunol Res 2020 Sep;12(5):877-884

Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

The mitochondrial genome encodes core catalytic peptides that affect major metabolic processes within a cell. Here, we investigated the association between mitochondrial DNA (mtDNA) variants and allergic diseases, including atopic dermatitis (AD) and asthma, alongside heteroplasmy within the mtDNA in subjects with allergic sensitization. We collected genotype data from 973 subjects with allergic sensitization, consisting of 632 children with AD, 498 children with asthma, and 481 healthy controls by extracting DNA from their blood samples. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.877DOI Listing
September 2020

MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.

Allergy Asthma Immunol Res 2020 Sep;12(5):859-876

NHC Key Laboratory of Antibody Technique, Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: CD4⁺T cells are essential in the pathogenesis of allergic asthma. We have previously demonstrated that microRNA-1165-3p (miR-1165-3p) was significantly reduced in T-helper type (Th) 2 cells and that miR-1165-3p was a surrogate marker for atopic asthma. Little is known about the mechanisms of miR-1165-3p in the regulation of Th2-dominated allergic inflammation. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.859DOI Listing
September 2020

Effect of Immunotherapy on Upper and Lower Airway Eosinophilic Inflammatory Response to Nasal Allergen Challenge.

Allergy Asthma Immunol Res 2020 Sep;12(5):844-858

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Purpose: It remains unknown whether allergen-specific immunotherapy (AIT) could attenuate airway inflammatory response triggered by allergen exposure.

Methods: We performed () nasal provocation tests (NPTs) in allergic rhinitis (AR) and/or asthma patients without AIT (non-AIT), or at 16, 52, 104, or 156 weeks after AIT. Rhinitis and asthma visual analog scale (VAS; VAS of nasal symptoms [VAS-NS], VAS of asthma symptoms), the rhinoconjunctivitis quality of life questionnaire (RQLQ), nasal lavage, sputum induction, fractional exhaled nitric oxide (FeNO), nasal airway resistance, pulmonary function, and airway hyperresponsiveness were performed before and after NPT. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.844DOI Listing
September 2020

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.

Allergy Asthma Immunol Res 2020 Sep;12(5):832-843

Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

Purpose: It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.832DOI Listing
September 2020

Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.

Allergy Asthma Immunol Res 2020 Sep;12(5):821-831

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Purpose: Chronic corticosteroid (CS) use is a risk factor for long-term mortality in asthmatic patients, and the presence of coexisting chronic obstructive pulmonary disease (COPD) is associated with a severe presentation and poor prognosis. However, the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma has not been well elucidated. This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.821DOI Listing
September 2020

Phenotypic and Molecular Characterization of Risk Loci Associated With Asthma and Lung Function.

Allergy Asthma Immunol Res 2020 Sep;12(5):806-820

Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, CT, United States.

Purpose: Respiratory diseases have a highly multifactorial etiology where different mechanisms contribute to the individual's susceptibility. We conducted a deep characterization of loci associated with asthma and lung function by previous genome-wide association studies (GWAS).

Methods: Sixteen variants were selected from previous GWAS of childhood/adult asthma and pulmonary function tests. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.806DOI Listing
September 2020

Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study.

Allergy Asthma Immunol Res 2020 Sep;12(5):792-805

Institute of MD Healthcare Inc., Seoul, Korea.

Purpose: Associations between a wide variety of diseases and the microbiome have been extensively verified. Recently, there has been a rising interest in the role the microbiome plays in atopic dermatitis (AD). Furthermore, metagenomic analysis of microbe-derived extracellular vesicles (EVs) has revealed the importance and relevance of microbial EVs in human health. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.792DOI Listing
September 2020

Management of Allergic Patients During the COVID-19 Pandemic in Asia.

Allergy Asthma Immunol Res 2020 Sep;12(5):783-791

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Although a viral infection is a major triggering factor of asthma and allergic diseases, asthma is suggested to be not a predisposing condition for coronavirus disease 2019 (COVID-19) infection. However, patients with severe asthma/allergic disease requiring systemic corticosteroids or immunosuppressive agents may be at higher risk of more severe clinical course of this infectious disease. For allergic patients who have been followed up at an allergy clinic in our region, it is recommended that they (patients with asthma, rhinitis, atopic dermatitis or chronic urticaria) continue to receive maintenance therapy and be in a well-controlled status. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.783DOI Listing
September 2020

An Overview of Rising CO₂ and Climatic Change on Aeroallergens and Allergic Diseases.

Authors:
Lewis H Ziska

Allergy Asthma Immunol Res 2020 Sep;12(5):771-782

Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

There are a number of implications of climate change in regard to human health. Among these, the role of rising carbon dioxide (CO₂) and temperature in aeroallergen exposure and associated changes in the start, duration and intensity of the pollen season, and associated consequences in aeroallergens and allergic disease are a primary concern. This review is intended to provide a synopsis of CO₂ and climate factors associated with likely changes in aeroallergen biology (indoor and outdoor), including changes in the demography of flowering plants, pollen seasonality, aeroallergen production, and potential biotic and abiotic interactions. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.771DOI Listing
September 2020

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria.

Allergy Asthma Immunol Res 2020 Sep;12(5):750-770

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H₁-antihistamines, even though the dose of H₁-antihistamines is increased up to 4-fold. CSU that is not controlled with H₁-antihistamines results in increased disease burden. Several immunomodulators have been used to manage these patients. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.750DOI Listing
September 2020

Joy of Ping-Pong: Genome-Wide and Phenome-Wide Association Studies.

Authors:
Heung Woo Park

Allergy Asthma Immunol Res 2020 Sep;12(5):748-749

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.748DOI Listing
September 2020

Does the Serum Tell Us Something About the Host-Microbial Relations in Allergic Diseases?

Authors:
You Sook Cho

Allergy Asthma Immunol Res 2020 Sep;12(5):745-747

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.745DOI Listing
September 2020

Parent-specific effects on risk of developing allergic sensitization and asthma in childhood.

Clin Exp Allergy 2020 Jul 7. Epub 2020 Jul 7.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Parent's history of atopic traits increases the risk of the same traits in their children, but mother's history may confer an increased risk compared to father's history.

Objective: To investigate parent-specific effects on risk of developing allergic sensitization and asthma in childhood.

Methods: We included 685 parent-child trios from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort. Read More

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http://dx.doi.org/10.1111/cea.13670DOI Listing

Patch testing with purified and oxidized citronellol.

Contact Dermatitis 2020 Jul 8. Epub 2020 Jul 8.

Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, Gothenburg, Sweden.

Background: Citronellol is a commonly used fragrance terpene included in fragrance mix II. As many other fragrance terpenes, citronellol is susceptible to autoxidation. Citronellol hydroperoxides are formed in large amounts and are the only oxidation products identified as sensitizers in oxidized citronellol. Read More

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http://dx.doi.org/10.1111/cod.13654DOI Listing

Single-cell RNA analysis: guiding the treatment of DiHS/DRESS.

Allergy 2020 Jul 7. Epub 2020 Jul 7.

Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain.

Drug-induced hypersensitivity syndrome (DiHS) ─also termed as drug reaction with eosinophilia and systemic symptoms (DRESS)─ is a potentially lethal inflammatory disease associated with human herpesvirus (HHV) reactivation. DiHS/DRESS is classified within a group of syndromes named severe cutaneous adverse reactions (SCARs), including acute generalized exanthematous pustulosis and Stevens-Johnson syndrome/toxic epidermal necrolysis. SCARs are delayed type IV hypersensitivity reactions mainly characterized by T-cell activation. Read More

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http://dx.doi.org/10.1111/all.14487DOI Listing

The Arabic Urticaria Activity Score and Chronic Urticaria Quality of Life Questionnaire: validation and correlations.

Int J Dermatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Dermatology, Henri-Mondor University Hospital, Creteil, France.

Background: The international guideline for urticaria recommends the use of the Urticaria Activity Score 7 (UAS7) and the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) to assess patients with chronic spontaneous urticaria (CSU) for their disease activity and impact on quality of life, respectively. Over the last decade, both tools have been validated in many different languages but not in Arabic.

Objective: To validate the Arabic UAS7 and CU-Q2oL in patients with CSU in Lebanon. Read More

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http://dx.doi.org/10.1111/ijd.15006DOI Listing

Pulmonary Aspergillosis: An Evolving Challenge for Diagnosis and Treatment.

Infect Dis Ther 2020 Jul 7. Epub 2020 Jul 7.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Aspergillus is a mold that may lead to different clinical pictures, from allergic to invasive disease, depending on the patient's immune status and structural lung diseases. Chronic pulmonary aspergillosis is an infection with a locally invasive presentation, reported especially in patients with chronic pulmonary disease, while aspergilloma is typically found in patients with previously formed cavities in the lungs. Allergic bronchopulmonary aspergillosis is due to a hypersensitivity reaction to Aspergillus antigens and is more frequently described in patients with moderate-severe asthma or cystic fibrosis. Read More

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http://dx.doi.org/10.1007/s40121-020-00315-4DOI Listing

Starting or Switching to an Integrase Inhibitor-Based Regimen Affects PTSD Symptoms in Women with HIV.

AIDS Behav 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street/ Meyer 6-113, Baltimore, MD, 21287-7613, USA.

As the use of Integrase inhibitor (INSTI)-class antiretroviral medications becomes more common to maintain long-term viral suppression, early reports suggest the potential for CNS side-effects when starting or switching to an INSTI-based regimen. In a population already at higher risk for developing mood and anxiety disorders, these drugs may have significant effects on PTSD scale symptom scores, particularly in women with HIV (WWH). A total of 551 participants were included after completing ≥ 1 WIHS study visits before and after starting/switching to an INSTI-based ART regimen. Read More

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http://dx.doi.org/10.1007/s10461-020-02967-2DOI Listing

Deficiency of Adenosine Deaminase 2 (DADA2): Hidden Variants, Reduced Penetrance, and Unusual Inheritance.

J Clin Immunol 2020 Jul 8. Epub 2020 Jul 8.

Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute (NHGRI), Bethesda, MD, USA.

Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disorder that manifests with fever, early-onset vasculitis, strokes, and hematologic dysfunction. This study aimed to identify disease-causing variants by conventional Sanger and whole exome sequencing in two families suspected to have DADA2 and non-confirmatory genotypes. ADA2 enzymatic assay confirmed the clinical diagnosis of DADA2. Read More

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http://dx.doi.org/10.1007/s10875-020-00817-3DOI Listing

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.

J Clin Immunol 2020 Jul 7. Epub 2020 Jul 7.

CHU Sainte-Justine, Department of Pediatrics, Department of Microbiology, Infectious Diseases and Immunology, University of Montreal, Montreal, QC, H3T 1C5, Canada.

Isolated neuroinflammatory disease has been described in case reports of familial hemophagocytic lymphohistiocytosis (FHL), but the clinical spectrum of disease manifestations, response to therapy and prognosis remain poorly defined. We combined an international survey with a literature search to identify FHL patients with (i) initial presentation with isolated neurological symptoms; (ii) absence of cytopenia and splenomegaly at presentation; and (iii) systemic HLH features no earlier than 3 months after neurological presentation. Thirty-eight (20 unreported) patients were identified with initial diagnoses including acute demyelinating encephalopathy, leukoencephalopathy, CNS vasculitis, multiple sclerosis, and encephalitis. Read More

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http://dx.doi.org/10.1007/s10875-020-00814-6DOI Listing

Ocular Manifestations of Chronic Granulomatous Disease: First Report of Coats' Disease and Literature Review.

J Clin Immunol 2020 Jul 7. Epub 2020 Jul 7.

Research Center for Immunodeficiencies, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1007/s10875-020-00810-wDOI Listing

A viral infection explanation for Kawasaki disease in general and for COVID-19 virus-related Kawasaki disease symptoms.

Authors:
Kevin Roe

Inflammopharmacology 2020 Jul 7. Epub 2020 Jul 7.

, 4975 Moorpark Ave, San Jose, CA, USA.

SARS-CoV-2, a new virus that appeared in Wuhan, China, in 2019 has approximately an 80% genomic match to the Severe Acute Respiratory Symptom (SARS) virus, which is known to come from a bat virus. Symptoms of Kawasaki disease in general and incomplete Kawasaki disease have been seen in a subset of pediatric patients having a current or previous infection of SARS-CoV-2. A viral infection, such as a SARS-CoV-2 virus infection, could result in extensive antigen-antibody immune complexes that cannot be quickly cleared in a subset of patients and thus create a type III hypersensitivity immune reaction and cause Kawasaki disease or Kawasaki disease symptoms (also known as multisystem inflammatory syndrome) in a subset of patients. Read More

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http://dx.doi.org/10.1007/s10787-020-00739-xDOI Listing

Cohort Profile Update: The Isle of Wight Whole Population Birth Cohort (IOWBC).

Int J Epidemiol 2020 Jul 8. Epub 2020 Jul 8.

Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.

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http://dx.doi.org/10.1093/ije/dyaa068DOI Listing

Risk of irritable bowel syndrome in patients who underwent appendectomy: A nationwide population-based cohort study.

EClinicalMedicine 2020 Jun 20;23:100383. Epub 2020 Jun 20.

Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China.

Background: Appendectomy is one of the most common surgical procedures; however, the possible long-term consequences have not been fully explored. The appendix has been associated with microflora of the gut and immune functions. However, literature examining the relationship between prior appendectomy and the risk of irritable bowel syndrome (IBS) is lacking. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329725PMC

Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Sci Adv 2020 Jun 26;6(26):eaba4353. Epub 2020 Jun 26.

Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, La Jolla, CA 92093, USA.

Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA) pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through systemic immunosuppression. FLS-targeted approaches could potentially be combined with DMARDs to improve control of RA without increasing immunosuppression. Read More

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http://dx.doi.org/10.1126/sciadv.aba4353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319753PMC

The fetal/placental weight ratio is associated with the incidence of atopic dermatitis in female infants during the first 14 months: The Hamamatsu Birth Cohort for Mothers and Children (HBC Study).

Int J Womens Dermatol 2020 Jun 5;6(3):176-181. Epub 2020 Mar 5.

Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Background: Among atopic diseases, atopic dermatitis is the most common allergic disease in children and influences both infantile and parental quality of life.

Objective: The present study investigated the sex-specific relationship between the fetal/placental weight ratio and The incidence of atopic dermatitis in infants during the first 14 months of life.

Methods: Study participants were 922 infants (462 female and 460 male) from singleton pregnancies enrolled in the Hamamatsu Birth Cohort for Mothers and Children (HBC Study) after the exclusion of 298 with missing data on atopic dermatitis. Read More

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http://dx.doi.org/10.1016/j.ijwd.2020.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330435PMC

Respiratory polygraphy data of children investigated for sleep-disordered breathing with different congenital or respiratory diseases.

Data Brief 2020 Aug 15;31:105859. Epub 2020 Jun 15.

Pediatric Pulmonology Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.

This short report describes respiratory indices of polygraphies (PG) performed to investigate several sleep-related disorders of breathing in children. It refers to the work of Michelet et al., Successful home respiratory polygraphy to investigate sleep-disordered breathing in children, Sleep Medicine [1]. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327810PMC

Diagnosis of a Lymphoenteric Fistula by Single-Photon Emission Computed Tomography/Computed Tomography Lymphoscintigraphy.

ACG Case Rep J 2020 Jun 11;7(6):e00388. Epub 2020 Jun 11.

Department of Allergy and Clinical Immunology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.

Protein losing enteropathy can present as an immunodeficiency. This report describes a rare cause of protein losing enteropathy due to a lymphoenteric fistula and how a novel use of a pre-existing combined imaging technique of single-photon emission computed tomography/computed tomography lymphoscintigraphy helped in making the diagnosis. Read More

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http://dx.doi.org/10.14309/crj.0000000000000388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304535PMC

Evaluation of the Anti-Tumor Activity of the Humanized Monoclonal Antibody NEO-201 in Preclinical Models of Ovarian Cancer.

Front Oncol 2020 19;10:805. Epub 2020 Jun 19.

Women's Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Despite high initial response rates with cytoreductive surgery, conventional chemotherapy and the incorporation of biologic agents, ovarian cancer patients often relapse and die from their disease. New approaches are needed to improve patient outcomes. This study was designed to evaluate the antitumor activity of NEO-201 monoclonal antibody (mAb) in preclinical models of ovarian cancer where the NEO-201 target is highly expressed. Read More

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http://dx.doi.org/10.3389/fonc.2020.00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318110PMC