463,367 results match your criteria Allergy asthma and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology[Journal]


Patient Attitude towards Videodermatoscopy for the Detection of Skin Cancer: A Cross-Sectional Study.

Oncol Res Treat 2019 Apr 17:1-6. Epub 2019 Apr 17.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany,

Background: Videodermatoscopy (VD) is a useful device for supporting dermatologists in the distinction between benign and malignant lesions. However, only few patients have access to VD in daily practice.

Objectives: To investigate patient attitudes towards VD. Read More

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http://dx.doi.org/10.1159/000499630DOI Listing

Study on neuroendocrine-immune function of Phenylethanoid Glycosides of Desertliving Cistanche herb in perimenopausal rat model.

J Ethnopharmacol 2019 Apr 14:111884. Epub 2019 Apr 14.

Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou, 450008, China.

Ethnopharmacological Relevance: Desertliving Cistanche herb was first recorded in "Shen Nong'Herbal Classic" and listed as the top grade herbal medicine in it. Phenylethanoid glycosides are indicative components for identification and content determination of Desertliving Cistanche herb in Chinese pharmacopoeia, which is also one of the main active components. In this research, we explored the mechanism of phenylethanoid glycosides of Desertliving Cistanche herb to the perimenopausal model rats. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111884DOI Listing

Clinical, immunologic, and molecular spectrum of patients with LPS-responsive beige-like anchor protein (LRBA) deficiency: a systematic review.

J Allergy Clin Immunol Pract 2019 Apr 14. Epub 2019 Apr 14.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:

Background: LPS-responsive beige-like anchor protein (LRBA) deficiency is a primary immunodeficiency and immune dysregulation syndrome caused by biallelic mutations in the LRBA gene. These mutations usually abrogate the protein expression of LRBA, leading to a broad spectrum of clinical phenotypes including autoimmunity, chronic diarrhea, hypogammaglobulinemia and recurrent infections.

Objective: Our aim was to systematically collect all studies reporting on the clinical manifestations, molecular and laboratory findings, and management of patients with LRBA deficiency. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.011DOI Listing

Sensitization of Nociceptors and Dorsal Horn Neurons Contributes to Pain in Sickle Cell Disease.

Neurosci Lett 2019 Apr 14. Epub 2019 Apr 14.

Department of Diagnostic and Biological Sciences, University of Minnesota, School of Dentistry, Minneapolis, MN 55455, United States. Electronic address:

Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vaso-occlusion episodes caused by accumulation of sRBCs results in ischemia-reperfusion injury, reduced oxygen supply to organs, oxidative stress, organ damage and severe pain that often requires hospitalization and opioid treatment. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.013DOI Listing

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation.

Immunity 2019 Apr;50(4):871-891

Laboratory of Immunoregulation and Infection, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

Cytokines are among the most important effector and messenger molecules in the immune system. They profoundly participate in immune responses during infection and inflammation, protecting against or contributing to diseases such as allergy, autoimmunity, and cancer. Manipulating cytokine pathways, therefore, is one of the most effective strategies to treat various diseases. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.03.020DOI Listing

Role of IgE-VH in FcεRIα and superantigen binding in allergy and immunotherapy.

J Allergy Clin Immunol 2019 Apr 14. Epub 2019 Apr 14.

Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR), Singapore; p53 Laboratory, Agency for Science, Technology and Research (A*STAR), Singapore. Electronic address:

Background: VH family frameworks have been reported to affect antibody receptor and superantigen binding, however such effects in IgE remains largely unknown. Given that VH family biases have been previously reported in IgE of certain allergies, there is a need to investigate this phenomenon for biotechnological and therapeutic purposes.

Objective: We sought to investigate the effects of VH families on IgE interaction with FcεRIα, anti-IgE Omalizumab, antigen, and superantigen spA using the Pertuzumab and Trastuzumab IgE models. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.03.028DOI Listing

Plerixafor for the Treatment of WHIM Syndrome. Reply.

N Engl J Med 2019 Apr;380(16)

National Institute of Allergy and Infectious Diseases, Bethesda, MD

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http://dx.doi.org/10.1056/NEJMc1901646DOI Listing

Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

N Engl J Med 2019 Apr;380(16):1535-1545

From United Biomedical, Hauppauge, NY (C.-Y.W., B.-S.K., C.L.F., F.W.-S.); United Biomedical Asia (C.-Y.W., S.L.) and United BioPharma (C.-Y.W., B.-S.K., H.-W.S., C.-Y.L., F.-C.T., A.L., F.-H.Y., C.-H.L., W.T., M.-J.L.), Hsinchu, Taipei Veterans General Hospital, Taipei (W.-W.W., H.-Y.L.), and Kaohsiung Veterans General Hospital (H.-C.T.) and Kaohsiung Medical University Hospital (Y.-H.C.), Kaohsiung - all in Taiwan; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (J.B., K.E.C., T.-W.C.); and the California Department of Public Health, Richmond (C.V.H.).

Background: Administration of a single broadly neutralizing human immunodeficiency virus (HIV)-specific antibody to HIV-infected persons leads to the development of antibody-resistant virus in the absence of antiretroviral therapy (ART). It is possible that monotherapy with UB-421, an antibody that blocks the virus-binding site on human CD4+ T cells, could induce sustained virologic suppression without induction of resistance in HIV-infected persons after analytic treatment interruption.

Methods: We conducted a nonrandomized, open-label, phase 2 clinical study evaluating the safety, pharmacokinetics, and antiviral activity of UB-421 monotherapy in HIV-infected persons undergoing analytic treatment interruption. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1802264
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http://dx.doi.org/10.1056/NEJMoa1802264DOI Listing
April 2019
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Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.

N Engl J Med 2019 Apr;380(16):1525-1534

From the Departments of Bone Marrow Transplantation and Cellular Therapy (E.M., B.T., W.J., S.G.), Hematology (S.Z., Z.M., J.C., J.D., X.T., B.Y.R., M.J.W., B.P.S.), Therapeutics Production and Quality (T.L., M.M.M.), Immunology (H.A., B.Y.), Pharmaceutical Sciences (S.J.C.), Biostatistics (G.K., C.L.), and Infectious Diseases (G.M.), St. Jude Children's Research Hospital, Memphis, TN; the Allergy and Clinical Immunology Division, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru (J.C.A.B.); the Department of Pediatrics, Allergy-Immunology Division, Children's Hospital Los Angeles, Los Angeles (J.A.C.), and the Department of Pediatrics, Division of Pediatric Allergy-Immunology-Bone Marrow Transplantation, University of California, San Francisco (UCSF) Benioff Children's Hospital, San Francisco (J.R.L.-B., J.M.P., M.J.C.) - both in California; the Department of Pediatrics, Pediatric Allergy and Immunology, University of New Mexico, Albuquerque (E.D.); University of Oklahoma Health Sciences Center, Tulsa (J.T.L.); Departamento de Pediatria da Universidade de Taubaté, Conselho Nacional de Medicina, São Paulo (A.C.M.A.); Copperfield Childcare, Claremont, South Africa (H.W.); and the Genetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (S.S.D.R., H.L.M.).

Background: Allogeneic hematopoietic stem-cell transplantation for X-linked severe combined immunodeficiency (SCID-X1) often fails to reconstitute immunity associated with T cells, B cells, and natural killer (NK) cells when matched sibling donors are unavailable unless high-dose chemotherapy is given. In previous studies, autologous gene therapy with γ-retroviral vectors failed to reconstitute B-cell and NK-cell immunity and was complicated by vector-related leukemia.

Methods: We performed a dual-center, phase 1-2 safety and efficacy study of a lentiviral vector to transfer complementary DNA to bone marrow stem cells after low-exposure, targeted busulfan conditioning in eight infants with newly diagnosed SCID-X1. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1815408
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http://dx.doi.org/10.1056/NEJMoa1815408DOI Listing
April 2019
4 Reads

Measles in 2019 - Going Backward.

N Engl J Med 2019 Apr 17. Epub 2019 Apr 17.

From the Department of Infectious Diseases, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA (C.I.P.); and the Office of the Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (H.D.M., A.S.F.).

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http://www.nejm.org/doi/10.1056/NEJMp1905099
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http://dx.doi.org/10.1056/NEJMp1905099DOI Listing
April 2019
6 Reads

Combined Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation to Model Inflammatory Lung Disease in Rheumatoid Arthritis.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

Veterans Affairs Nebraska-Western Iowa Health Care System, Research Service, Omaha, NE.

Objectives: Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including lung disease, yet the mechanisms linking the two conditions are poorly understood. The collagen-induced arthritis (CIA) model was combined with the organic dust extract (ODE) airway inflammatory model to assess bone/joint-lung inflammatory outcomes.

Methods: DBA/1J mice were intranasally treated with saline or ODE daily for 5 weeks. Read More

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http://dx.doi.org/10.1002/jbmr.3745DOI Listing

Detection of serum and salivary IgE and IgG1 immunoglobulins specific for diagnosis of food allergy.

PLoS One 2019 17;14(4):e0214745. Epub 2019 Apr 17.

Laboratory of Biotechnology and Molecular Biology, State University of Ceará, Fortaleza, Ceará, Brazil.

Given the growing incidence and prevalence of life-threatening food allergies, health concerns have raised new perspectives for in vivo and in vitro diagnostic methodologies, pointing to saliva as a promising material, already used to diagnose other pathologies. Based on the above considerations, this study aimed to verify the possible use of saliva for the detection of IgE and IgG1 in the diagnosis of food allergy. This was a randomized, cross-sectional clinical study with a quantitative approach, developed at a hospital referral center in allergy in the state of Ceará, from January to July 2015. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214745PLOS

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.

PLoS One 2019 17;14(4):e0215163. Epub 2019 Apr 17.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

The vaccine elicitation of broadly neutralizing responses is a central goal of HIV research. Recently, we elicited cross-clade neutralizing responses against the N terminus of the fusion peptide (FP), a critical component of the HIV-entry machinery. While the consistency of the elicited cross-clade neutralizing responses was good in mice, it was poor in guinea pigs: after seven immunizations comprising either envelope (Env) trimer or FP coupled to a carrier, serum from only one of five animals could neutralize a majority of a cross-clade panel of 19 wild-type strains. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215163PLOS

Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.

J Drug Target 2019 Apr 17:1-25. Epub 2019 Apr 17.

b Medical Physics & Biomedical Engineering, University College London , Gower, Street , London , UK.

Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1608552DOI Listing

Transcriptomic responses to Ivacaftor and prediction of Ivacaftor clinical responsiveness.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Pittsburgh, Medicine, Pittsburgh, Pennsylvania, United States ;

Ivacaftor is a recently FDA-approved drug for the treatment of cystic fibrosis (CF) patients with at least one copy of the G511D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The transcriptomic effect of Ivacaftor in CF patients remains unclear. We aim to examine if and how the transcriptome of patients is influenced by Ivacaftor treatment and to determine if these data allow prediction of Ivacaftor responsiveness. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2019-0032OC
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http://dx.doi.org/10.1165/rcmb.2019-0032OCDOI Listing
April 2019
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The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
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http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
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Unusual vaginal bleeding due to a leech bite in a girl from a tropical area: A case report.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180425. Epub 2019 Apr 11.

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

This study describes the isolation of a leech following the presentation of unusual vaginal bleeding. Vaginal bleeding in children due to a leech bite is very rare. This is the first report of severe bleeding in a virgin 14-year-old girl from Mashhad, Iran due to the presence of a leech in the vagina. Read More

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http://dx.doi.org/10.1590/0037-8682-0425-2018DOI Listing

β-Lactam Allergy in the Operating Theater: Reply.

Anesthesiology 2019 May;130(5):855-856

Academic Medical Center, AMC Amsterdam, Amsterdam, The Netherlands (J.H.).

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http://dx.doi.org/10.1097/ALN.0000000000002690DOI Listing

β-Lactam Allergy in the Operating Theater: Comment.

Anesthesiology 2019 May;130(5):854-855

University of Toronto, Toronto, Ontario, Canada (L.V.).

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http://dx.doi.org/10.1097/ALN.0000000000002689DOI Listing

β-Lactam Allergy in the Operating Theater: Comment.

Anesthesiology 2019 May;130(5):853-854

University of British Columbia, Vancouver, British Columbia, Canada (A.T.M.).

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http://dx.doi.org/10.1097/ALN.0000000000002688DOI Listing

Coevolution of HIV-1 and broadly neutralizing antibodies.

Curr Opin HIV AIDS 2019 Apr 15. Epub 2019 Apr 15.

IAVI Neutralizing Antibody Center, Immunology and Microbiology Department, The Scripps Research Institute, La Jolla, California, USA.

Purpose Of Review: Exploring the molecular details of the coevolution of HIV-1 Envelope with broadly neutralizing antibodies (bNAbs) in infected individuals over time provides insights for vaccine design. Since mid-2017, the number of individuals described in such publications has nearly tripled. New publications have extended such studies to new epitopes on Env and provided more detail on previously known sites. Read More

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http://dx.doi.org/10.1097/COH.0000000000000550DOI Listing
April 2019
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Anaphylaxis after wheat ingestion in a patient with coeliac disease: two kinds of reactions and the same culprit food.

Eur J Gastroenterol Hepatol 2019 Apr 15. Epub 2019 Apr 15.

Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.

In recent years, the role of atopic dermatitis epidermal skin barrier defects in inducing a transcutaneous allergic sensitization is highly debated, possibly explaining why some children with eczema are sensitized to foods they have never eaten. In our specific situation, the association between coeliac disease and wheat allergy might be particularly harmful owing to unavoidable strict food avoidance. We describe the case of a young boy affected by coeliac disease who, after an occasional unexpected ingestion of gluten, experienced a complete anaphylactic reaction characterized by urticarial, labial angioedema, wheezing, and hypotension. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001421DOI Listing
April 2019
1 Read

IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

Background: Glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine expression and induce apoptosis. Asthma severity is associated with type 2 inflammation, circulating Th2 cells and higher GC requirements.

Objective: The aim of this study was to assess whether ex vivo production of interleukin 2 (IL-2), a T-cell survival factor, associated with clinical features of asthma severity, the proportion of blood Th2 cells and Th2 cell responses to GC. Read More

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http://dx.doi.org/10.1002/iid3.249DOI Listing

Drug survival and reasons for drug discontinuation in palmoplantar pustulosis: a retrospective multicenter study.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Georg-August-University Göttingen, Göttingen, Germany.

Background: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease-related to psoriasis. Its treatment is challenging, and little is known about the sustainability of different medications. The aim of this study was to analyze drug survival rates and drug discontinuation in the treatment of PPP under real-world conditions. Read More

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http://dx.doi.org/10.1111/ddg.13834DOI Listing

Diagnosis and treatment of IgE-mediated insulin hypersensitivity: two case reports.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Eberhard Karls University, Tübingen, Germany.

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http://dx.doi.org/10.1111/ddg.13832DOI Listing
April 2019
1 Read

Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Lymph node tuberculosis (LNTB) is characterized by the enhanced baseline and antigen-specific production of type 1/17 cytokines and reduced baseline and antigen-specific production of interleukin (IL)-1β and IL-18 at the site of infection when compared with peripheral blood. However, the cytokine profile in the lymph nodes (LNs) of culture-positive LNTB (LNTB+) and negative LNTB (LNTB-) has not been examined. To address this, we have examined the baseline and mycobacterial antigen-stimulated cytokine levels of type 1 (interferon gamma [IFNγ], tumor necrosis factor alpha [TNFα], IL-2), type 2 (IL-4, IL-5, and IL-13), type 17 (IL-17A, IL-17F, and IL-22), pro-inflammatory (IL-1α, IL-1β, IL-18, and GM-CSF), and regulatory cytokines (IL-10, TGFβ) in the LN culture supernatants of LNTB+ and LNTB- individuals. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0834DOI Listing

Safety and Differential Antibody and T-Cell Responses to Sporozoite Vaccine by Age in Tanzanian Adults, Adolescents, Children, and Infants.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Sanaria, Inc., Rockville, Maryland.

In 2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria PfSPZ Vaccine, composed of radiation-attenuated, aseptic, purified, cryopreserved (Pf) sporozoites (SPZ) has been well tolerated and safe in malaria-naïve and experienced adults in the United States and Mali and protective against controlled human malaria infection with Pf in the United States and field transmission of Pf in Mali, but had not been assessed in younger age groups. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0835DOI Listing

Early outcomes after implementation of treat all in Rwanda: an interrupted time series study.

J Int AIDS Soc 2019 Apr;22(4):e25279

Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA.

Introduction: Nearly all countries in sub-Saharan Africa have adopted policies to provide antiretroviral therapy (ART) to all persons living with HIV (Treat All), though HIV care outcomes of these programmes are not well-described. We estimated changes in ART initiation and retention in care following Treat All implementation in Rwanda in July 2016.

Methods: We conducted an interrupted time series analysis of adults enrolling in HIV care at ten Rwandan health centres from July 2014 to September 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jia2.25279
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http://dx.doi.org/10.1002/jia2.25279DOI Listing
April 2019
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Recombinant Human C1 Esterase Inhibitor Treatment for Hereditary Angioedema Attacks in Children.

Pediatr Allergy Immunol 2019 Apr 16. Epub 2019 Apr 16.

Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1-INH (rhC1-INH) for HAE attacks in children. Read More

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http://dx.doi.org/10.1111/pai.13065DOI Listing

Bacterial l-asparaginases for cancer therapy: Current knowledge and future perspectives.

J Cell Physiol 2019 Apr 16. Epub 2019 Apr 16.

Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

l-Asparaginases hydrolyzing plasma l-asparagine and l-glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies. Cancer cells reduce the expression of l-asparaginase leading to their elimination. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28563
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http://dx.doi.org/10.1002/jcp.28563DOI Listing
April 2019
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Medical Algorithm: Diagnosis and Treatment of Chronic Rhinosinusitis.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Upper Airway Research Laboratory, Ghent University Hospital, Dep. of Otorhinolaryngology, Ghent, Belgium.

Chronic rhinosinusitis (CRS) is a disease affecting more than 10% of the European population, causing symptoms and impacting quality of life. CRS is classically differentiated into disease without and with nasal polyps (CRSsNP, CRSwNP) based on clinical signs, specifically using nasal endoscopy for diagnosis (1). However, the differentiation into phenotypes allows to conclude on dominant remodelling patterns (fibrosis in CRSsNP or oedema and polyp formation in CRSwNP), but does only partly predict the natural course of disease; phenotypes do not adequately appreciate the current discussion about different surgical approaches or innovative biologics. Read More

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http://dx.doi.org/10.1111/all.13823DOI Listing

Critical functions of the polyamine putrescine for proliferation and viability of Leishmania donovani parasites.

Amino Acids 2019 Apr 16. Epub 2019 Apr 16.

Pacific University School of Pharmacy, Hillsboro, OR, 97123, USA.

Polyamines are metabolites that play important roles in rapidly proliferating cells, and recent studies have highlighted their critical nature in Leishmania parasites. However, little is known about the function of polyamines in parasites. To address this question, we assessed the effect of polyamine depletion in Leishmania donovani mutants lacking ornithine decarboxylase (Δodc) or spermidine synthase (Δspdsyn). Read More

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http://dx.doi.org/10.1007/s00726-019-02736-zDOI Listing

Susceptibility to SIV Infection After Adenoviral Vaccination in a Low Dose Rhesus Macaque Challenge Model.

Pathog Immun 2019 29;4(1):1-20. Epub 2019 Jan 29.

Department of Microbiology; Perelman School of Medicine, University of Pennsylvania; Philadelphia, Pennsylvania.

Background: Vaccination with the Merck human adenovirus serotype-5 (HAdV-5) vectored HIV-1 subtype B gag/pol/nef vaccine was unexpectedly associated with enhanced susceptibility to HIV-1 infection in uncircumcised HAdV-5 seropositive men. It has been hypothesized that vaccination may have resulted in activated CD4+ T lymphocytes trafficking to mucosal sites thereby increasing targets for HIV infection. We have previously shown that AdV-vector vacci-nation in rhesus macaques resulted in an increase in the frequency of activated mucosal CD4+ T cells. Read More

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http://dx.doi.org/10.20411/pai.v4i1.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457171PMC
January 2019

Early and Pre-Clinical Detection of Prion Seeding Activity in Cerebrospinal Fluid of Goats using Real-Time Quaking-Induced Conversion Assay.

Sci Rep 2019 Apr 16;9(1):6173. Epub 2019 Apr 16.

National Reference Laboratory of TSEs (CEA), Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, Turin, Italy.

Since 2005, two cases of natural bovine spongiform encephalopathies (BSE) have been reported in goats. Furthermore, experimental transmissions of classical (C-BSE) and atypical (L-BSE) forms of BSE in goats were also reported. To minimize further spreading of prion diseases in small ruminants the development of a highly sensitive and specific test for ante-mortem detection of infected animals would be of great value. Read More

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http://dx.doi.org/10.1038/s41598-019-42449-7DOI Listing

Structure-based Design of JOC-x, a Conjugatable Tumor Tight Junction Opener to Enhance Cancer Therapy.

Sci Rep 2019 Apr 16;9(1):6169. Epub 2019 Apr 16.

PAI Life Sciences, Inc., Seattle, WA, USA.

Disorganized intercellular junctions are critical for maintaining the integrity of solid epithelial tumors and prevent the infiltration of oncological therapies into the bulk of the malignancy. We have developed small, recombinant proteins which bind a critical junction protein, desmoglein 2, triggering the transient and specific opening of tumor tight junctions allowing for infiltration of the tumor with immune cells, oncolytic viruses, drugs, and other therapeutics. Our new molecule, JOC-x, is a promising candidate for a new class of tumor-targeting agents that accumulate both around and within tumors and remodel the tumor microenvironment. Read More

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http://www.nature.com/articles/s41598-019-42229-3
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http://dx.doi.org/10.1038/s41598-019-42229-3DOI Listing
April 2019
1 Read

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).

Clin Exp Otorhinolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.

Methods: Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. Read More

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http://dx.doi.org/10.21053/ceo.2018.01781DOI Listing
April 2019
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Selective fibrinogen cleavage by diverse proteinases initiates innate allergic and antifungal immunity through CD11b.

J Biol Chem 2019 Apr 16. Epub 2019 Apr 16.

Pathology & Immunology, Baylor College of Medicine, United States.

Proteinases are essential drivers of allergic airway disease and innate antifungal immunity in part through their ability cleave the clotting factor fibrinogen (FBG) into fibrinogen cleavage products (FCPs) that signal through Toll like receptor 4 (TLR4).  However, the mechanism by which FCPs engage TLR4 remains unknown.  Here we show that the proteinases from Aspergillus melleus (PAM) and other allergenic organisms rapidly hydrolyze FBG to yield relatively few FCPs that drive distinct antifungal mechanisms through TLR4. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006724DOI Listing

Subpollens delivery of Platanus acerifolia pollen allergen Pla a3 and nucleic acid into lungs and cells.

Biochem Biophys Res Commun 2019 Apr 13. Epub 2019 Apr 13.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. Electronic address:

Pollen allergy is a very serious seasonal respiratory disease. However, there has been a lack of understanding how pollen allergens enter the body and act on cells. This study focused on the release, transport and characteristic of Pla a3 allergen of the Platanus acerifolia pollen. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.210DOI Listing

MEDITERRANEAN DIET AND ASTHMA: TIME FOR CLINICAL TRIALS IN CHILDREN.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):207-208

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; IMIB Bio-health Research Institute; and ARADyAL allergy network, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.04.001DOI Listing

Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat.

Epigenetics Chromatin 2019 Apr 16;12(1):23. Epub 2019 Apr 16.

Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.

Background: Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV-1 promoter. The HIV-1 Tat protein regulates the passage from viral latency to active transcription by binding to the viral mRNA hairpin (TAR) and recruiting transcriptional factors to promote transcriptional elongation. The Tat inhibitor didehydro-Cortistatin A (dCA) inhibits transcription and overtime, the lack of low-grade transcriptional events, triggers epigenetic changes at the latent loci that "lock" HIV transcription in a latent state. Read More

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http://dx.doi.org/10.1186/s13072-019-0267-8DOI Listing

eNetXplorer: an R package for the quantitative exploration of elastic net families for generalized linear models.

BMC Bioinformatics 2019 Apr 16;20(1):189. Epub 2019 Apr 16.

Trans-NIH Center for Human Immunology (CHI), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Background: Regularized generalized linear models (GLMs) are popular regression methods in bioinformatics, particularly useful in scenarios with fewer observations than parameters/features or when many of the features are correlated. In both ridge and lasso regularization, feature shrinkage is controlled by a penalty parameter λ. The elastic net introduces a mixing parameter α to tune the shrinkage continuously from ridge to lasso. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2778-5DOI Listing
April 2019
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Impact of Reported β-Lactam Allergy on Management of Methicillin-Sensitive Staphylococcus aureus Bloodstream Infections.

J Pharm Pract 2019 Apr 16:897190019841737. Epub 2019 Apr 16.

1 Henry Ford Hospital, Detroit, MI, USA.

Background: Antistaphylococcal β-lactams antibiotics are the preferred treatment for methicillin-sensitive Staphylococcus aureus (MSSA) infections. Patient-reported β-lactam allergies may complicate antibiotic decision-making and delay optimal therapy, with potential implications on patient outcomes.

Objective: To determine the impact of reported β-lactam allergies on the receipt of optimal therapy and outcomes for MSSA bloodstream infections (BSI). Read More

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http://dx.doi.org/10.1177/0897190019841737DOI Listing

Estimation of the Allergenic Potential of Urban Trees and Urban Parks: Towards the Healthy Design of Urban Green Spaces of the Future.

Int J Environ Res Public Health 2019 Apr 15;16(8). Epub 2019 Apr 15.

Slovenian Forestry Institute, 1000 Ljubljana, Slovenia.

The impact of allergens emitted by urban green spaces on health is one of the main disservices of ecosystems. The objective of this work is to establish the potential allergenic value of some tree species in urban environments, so that the allergenicity of green spaces can be estimated through application of the Index of Urban Green Zones Allergenicity (I). Multiple types of green spaces in Mediterranean cities were selected for the estimation of I. Read More

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http://dx.doi.org/10.3390/ijerph16081357DOI Listing

NFκB- and MAP-Kinase Signaling Contribute to the Activation of Murine Myeloid Dendritic Cells by a Flagellin A:Allergen Fusion Protein.

Cells 2019 Apr 15;8(4). Epub 2019 Apr 15.

Paul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany.

Fusion proteins incorporating the TLR5-ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. We recently reported a flagellin:allergen fusion protein containing the TLR5-ligand flagellin A (FlaA) from and the major birch pollen allergen Bet v 1 (rFlaA:Betv1) to prevent allergic sensitization in an experimental mouse model. This study analyzes the signaling pathways contributing to rFlaA:Betv1-mediated pro- and anti-inflammatory cytokine secretion and cell metabolism in myeloid dendritic cells (mDCs) in vitro. Read More

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http://dx.doi.org/10.3390/cells8040355DOI Listing

Platelets are important for the development of immune tolerance: possible involvement of TGF-β in the mechanism.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Platelets have diverse roles in immune processes in addition to their key functions in hemostasis and thrombosis. Some studies imply that platelets may be possibly related to the immune tolerance induction. However, the role of platelets in the development of immune tolerance is not fully understood. Read More

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http://dx.doi.org/10.1111/exd.13940DOI Listing
April 2019
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Sugammadex-induced anaphylaxis involving sudden onset of severe abdominal pain.

J Clin Anesth 2019 Apr 13;57:119-120. Epub 2019 Apr 13.

Anesthesiology and Clinical Physiology, Tokyo Medical and Dental University, Japan.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.012DOI Listing

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.

Neuropharmacology 2019 Apr 13. Epub 2019 Apr 13.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Centro de Inovação e Ensaios Pre-Clínicos - CIEnP, Florianópolis, SC, Brazil. Electronic address:

Painful peripheral neuropathy is the most dose-limiting side effect of paclitaxel (PTX), a widely used anti-cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to the development of new therapeutic approaches. CXCL1 chemokine and its receptor CXCR2 have been pointed as promising targets to treat chronic pain. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.04.014DOI Listing

Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia.

Exp Eye Res 2019 Apr 13. Epub 2019 Apr 13.

Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D-85764, Neuherberg, Germany. Electronic address:

During an ENU (N-ethyl-N-nitrosourea) mutagenesis screen, we observed a dominant small-eye mutant mouse with viable homozygotes. A corresponding mutant line was established and referred to as Aey69 (abnormality of the eye #69). Comprehensive phenotyping of the homozygous Aey69 mutants in the German Mouse Clinic revealed only a subset of statistically significant alterations between wild types and homozygous mutants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183070
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http://dx.doi.org/10.1016/j.exer.2019.03.024DOI Listing
April 2019
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