148,818 results match your criteria Allergy asthma & immunology research[Journal]


The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
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http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
1 Read

IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

Background: Glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine expression and induce apoptosis. Asthma severity is associated with type 2 inflammation, circulating Th2 cells and higher GC requirements.

Objective: The aim of this study was to assess whether ex vivo production of interleukin 2 (IL-2), a T-cell survival factor, associated with clinical features of asthma severity, the proportion of blood Th2 cells and Th2 cell responses to GC. Read More

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http://dx.doi.org/10.1002/iid3.249DOI Listing

MEDITERRANEAN DIET AND ASTHMA: TIME FOR CLINICAL TRIALS IN CHILDREN.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):207-208

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; IMIB Bio-health Research Institute; and ARADyAL allergy network, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.04.001DOI Listing

Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

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http://dx.doi.org/10.1111/all.13824DOI Listing

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
1 Read

Intranasal administration of (Cooke) Ryvarden (Tiger Milk mushroom) extract attenuates airway inflammation in murine model of allergic asthma.

Exp Ther Med 2019 May 20;17(5):3867-3876. Epub 2019 Mar 20.

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150 Malaysia.

Asthma is a chronic inflammatory disorder in the airways that involves the activation of cells and mediators. (Cooke) Ryvardan or Tiger Milk mushroom is a medicinal mushroom that is traditionally used to treat inflammatory diseases including asthma. In this study, the protective effects of intranasal administration of extract (LRE) in ovalbumin (OVA)-induced airway inflammation mouse model were investigated. Read More

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http://dx.doi.org/10.3892/etm.2019.7416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447947PMC

Omalizumab in patients with severe asthma and persistent sputum eosinophilia.

Allergy Asthma Clin Immunol 2019 3;15:21. Epub 2019 Apr 3.

1Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON Canada.

Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. Read More

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http://dx.doi.org/10.1186/s13223-019-0337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448265PMC

Implications of prostaglandin D2 and leukotrienes in exhaled breath condensates of asthma.

Ann Allergy Asthma Immunol 2019 Apr 12. Epub 2019 Apr 12.

Department of Respiratory Medicine, Saitama Medical University, Iruma-gun, Saitama 350-0495, Japan; Allergy Center, Saitama Medical University Hospital, Iruma-gun, Saitama 350-0495, Japan.

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http://dx.doi.org/10.1016/j.anai.2019.04.008DOI Listing

PTGDR expression is upregulated through retinoic acid receptors (RAR) mechanism in allergy.

PLoS One 2019 15;14(4):e0215086. Epub 2019 Apr 15.

Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain.

Functional studies suggest that promoter polymorphisms of the Prostaglandin D Receptor (PTGDR) gene can be involved in asthma. All-trans Retinoic acid (ATRA) has also been linked to allergic diseases. We have previously described the PTGDR promoter activation mediated by ATRA through response elements (RARE) at position -549T> C. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215086PLOS
April 2019
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Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Pediatr Allergy Immunol 2019 Apr 15. Epub 2019 Apr 15.

Telethon Kids Institute, University of Western Australia, WA, Australia.

Background: Antigen specific IgE binds the Fcε receptor I (FcεRI) expressed on several types of immune cells, including dendritic cells (DC). Activation of FcεRI on DCs in atopics has been shown to modulate immune responses that potentially contribute to asthma development. However, the extent to which DC subsets differ in FcεRI expression between atopic children with or without asthma is currently not clear. Read More

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http://dx.doi.org/10.1111/pai.13063DOI Listing

The Patient Needs in Asthma Treatment (NEAT) questionnaire: Further evidence on its psychometric properties.

Allergy 2019 Apr 15. Epub 2019 Apr 15.

Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Düsseldorf, Germany.

Background: Building on previous psychometric work, we sought to assess the Patient Needs in Asthma Treatment (NEAT) questionnaire's validity, responsiveness to change and the minimal important change (MIC) over a 3-year period (Study 1) and its reliability and the smallest detectable change (SDC) in a test-retest-study (Study 2) among patients self-reporting physician-diagnosed asthma.

Methods: In Study 1, a total of 207 patients completed a survey which included the NEAT, the Asthma Control Test (ACT), the Asthma Quality of Life Questionnaire-Sydney (AQLQ-S) and a question on treatment satisfaction in 2014 and 2017. In Study 2, a total of 78 patients completed NEAT twice on average four weeks apart in 2018. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13782
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http://dx.doi.org/10.1111/all.13782DOI Listing
April 2019
1 Read

Short-course administration of a traditional herbal mixture ameliorates asthma symptoms of the common cold in children.

Avicenna J Phytomed 2019 Mar-Apr;9(2):126-133

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Asthma is an increasing chronic respiratory disease affecting over 300 million people worldwide. Several studies have shown that herbal remedies may improve asthma control and reduce asthma symptoms. In this study, the effects of short-course administration of an herbal mixture (ASMATUS) in asthmatic children during viral respiratory tract infection, were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448545PMC

IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

Clin Mol Allergy 2019 2;17. Epub 2019 Apr 2.

Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Read More

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http://dx.doi.org/10.1186/s12948-019-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444864PMC

Prenatal vitamin D levels and child wheeze and asthma.

J Matern Fetal Neonatal Med 2019 Apr 14:1-241. Epub 2019 Apr 14.

b Division of General Pediatrics , Department of Pediatrics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.

Background: Maternal vitamin D status during pregnancy may influence lung development and risk of childhood wheeze and asthma. We investigated the relationship between prenatal vitamin D and child asthma in a racially diverse cohort with a high burden of vitamin D insufficiency and child asthma.

Methods: We included mother-child dyads in the prenatal Conditions Affecting neurocognitive Development and Learning in Early Childhood (CANDLE) cohort (2006-2011, Shelby County, Tennessee). Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1607286DOI Listing
April 2019
4 Reads

Evaluating fluticasone furoate + vilanterol for the treatment of chronic obstructive pulmonary disease (COPD).

Expert Opin Pharmacother 2019 Apr 14:1-11. Epub 2019 Apr 14.

a Pulmonary, Critical Care, Allergy and Sleep Medicine , Medical University of South Carolina , Charleston , SC , USA.

Introduction: Inhaled corticosteroid/long-acting β-2 agonists (ICS/LABA) combination inhalers have been a lifeline for a generation of chronic obstructive pulmonary disease (COPD) and asthma patients. Fluticasone furoate and Vilanterol (FF/VI) as a once-daily ICS/LABA combination have an extensive clinical trial and real-world data to support its use in COPD patients. Areas covered: The authors provide pharmacological profiles of fluticasone furoate, vilanterol and the FF/VI fixed dose combination. Read More

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http://dx.doi.org/10.1080/14656566.2019.1603292DOI Listing
April 2019
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Favorable clinical efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma: a 48-week pilot study.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy and Respiratory Medicine, Sutoh Hospital, Annaka, Gunma, Japan.

Summary: Assessing efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma patients. This study was a 48-week prospective open-label analysis of mepolizumab in 11 asthmatics with chronic rhinosinusitis (CRS). It was administered every 4 weeks. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.94DOI Listing

Frequency of allergic sensitization to Can f 5 in North East Italy. An analysis of 1403 ISACs 112 (Component Resolved Diagnosis) collected retrospectively.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Postgraduate School of Respiratory Medicine. Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Summary: Recent studies have shown the increasing relevance of allergic sensitization to Can f 5, a prostatic kallicrein expressed in the prostate and detectable only in male dogs. The aim of the present study was to establish the frequency, level of sensitization and association with other dog allergens of Can f 5, as assessed by Component Resolved Diagnosis (CRD- ISAC 112, ThermoFisher Scientific, Uppsala, Sweden), in North East Italy. A total of 1403 CRD ISAC 112 were examined retrospectively. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.89DOI Listing

Chronicity of Mental Comorbidity in Children with New-onset Physical Illness.

Child Care Health Dev 2019 Apr 14. Epub 2019 Apr 14.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Background: Evidence suggests that physical and mental illness are strongly correlated in children. This study examined patterns of the chronicity of multimorbidity (co-occurring physical and mental illness); estimated homotypic continuity; and, modelled factors associated with chronicity in children newly diagnosed with a chronic physical illness.

Methods: Children aged 6-16 years diagnosed with one of asthma, diabetes, epilepsy, food allergy, or juvenile arthritis were recruited from two children's hospitals and followed for six months. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cch.12667
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http://dx.doi.org/10.1111/cch.12667DOI Listing
April 2019
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Contemporary analysis of otolaryngic allergy.

Laryngoscope 2019 Apr 14. Epub 2019 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, UNC Neuroscience Hospital, Chapel Hill, North Carolina, U.S.A.

Objectives: Investigate the current trends in otolaryngic allergy (OA).

Study Design: Cross-sectional survey.

Methods: Survey of active AAOA membership. Read More

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http://dx.doi.org/10.1002/lary.28002DOI Listing

Benzo(a)pyrene Facilitates Dermatophagoides Group 1 (Der f 1)-Induced Epithelial Cytokine Release through Aryl Hydrocarbon Receptor in Asthma.

Allergy 2019 Apr 14. Epub 2019 Apr 14.

The Affiliated Luohu Hospital of Shenzhen University, Shenzhen, Luohu Hospital Group, Shenzhen, China.

Background: Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co-exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1-induced asthma and its underlying mechanisms. Read More

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http://dx.doi.org/10.1111/all.13784DOI Listing

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):772S-799S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

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http://dx.doi.org/10.1093/ajcn/nqy283DOI Listing
March 2019
6.770 Impact Factor

Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):890S-934S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: Nutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.

Objectives: The aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?

Methods: The literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. Read More

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http://dx.doi.org/10.1093/ajcn/nqy220DOI Listing
March 2019
2 Reads
6.770 Impact Factor

A case of Mycobacterium tuberculosis laboratory cross-contamination.

J Infect Chemother 2019 Apr 11. Epub 2019 Apr 11.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan; Department of Basic Mycobacteriology, Graduate School of Biomedical Science, Nagasaki University, Japan. Electronic address:

Setting: A laboratory cross-contamination event was suspected because Mycobacterium tuberculosis was unexpectedly detected at a high incidence in the cultures of several clinical specimens at the National Hospital Organization, Tokyo National Hospital, Japan.

Objective: To describe a case of Mycobacterium tuberculosis laboratory cross-contamination.

Design: We reviewed the medical records of 20 patients whose clinical specimens were suspected to have been contaminated by Mycobacterium tuberculosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1341321X193007
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http://dx.doi.org/10.1016/j.jiac.2019.03.012DOI Listing
April 2019
1 Read

DNA methylation and a biomarker panel to predict asthma development.

Authors:
Harald Renz

J Allergy Clin Immunol 2019 Apr 11. Epub 2019 Apr 11.

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL) Marburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.04.002DOI Listing

Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

J Affect Disord 2019 Apr 9;252:60-67. Epub 2019 Apr 9.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, 542 No.161, Yu-Pin Rd, Caotun Township, Nantou, Taiwan, R.O.C.. Electronic address:

Background: Studies have reported an association between allergy and panic disorder. However, few studies have explored the relationship between allergic rhinitis and panic disorder. Previous studies were limited by cross-sectional study designs, self-reported symptoms, absence of matched controls, and lack of consideration of the influence of steroid and comorbidities. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.037DOI Listing

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

Environ Int 2019 Apr 10;127:503-513. Epub 2019 Apr 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, USA.

Background: Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations.

Objectives: To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma.

Methods: We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. Read More

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http://dx.doi.org/10.1016/j.envint.2019.04.003DOI Listing

The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma.

Clin Exp Allergy 2019 Apr 12. Epub 2019 Apr 12.

Division of Asthma -Exacerbation& -Regulation, Priority Area Asthma & Allergy, Research Center Borstel- Leibniz Lung Center, Borstel, Germany.

Background: Originally, the neuropeptide α-melanocyte-stimulating hormone (α-MSH) has been described as a mediator of skin pigmentation. However, recent studies have shown that α-MSH is able to modulate inflammation in various tissues including the lung. So far, it is still not clear, whether α-MSH also plays a role in allergic bronchial asthma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13400
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http://dx.doi.org/10.1111/cea.13400DOI Listing
April 2019
5 Reads

Analysis of allergens in corn-dependent exercise-induced anaphylaxis.

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Fujita Health University General Allergy Center, Nagoya, Japan.

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http://dx.doi.org/10.1016/j.anai.2019.04.005DOI Listing
April 2019
1 Read

Peanut-Allergic Patient Experiences After Epicutaneous Immunotherapy: Peanut Consumption and Impact on QoL.

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.anai.2019.04.006DOI Listing

Allergy to Mus m 1: Allergy to Mus m 1: A review of structural, and immunological features.

Immunol Lett 2019 Apr 9;209:1-3. Epub 2019 Apr 9.

Medical Research Group (GINUMED) Universitary Corporation Rafael Nuñez, Colombia.

The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478193005
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http://dx.doi.org/10.1016/j.imlet.2019.03.012DOI Listing
April 2019
2 Reads

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial.

Am J Respir Crit Care Med 2019 Apr 12. Epub 2019 Apr 12.

Brigham and Women's Hospital Department of Medicine, 370908, Division of Rheumatology, Immunology, and Allergy, Boston, Massachusetts, United States.

Rationale: Daily high-dose aspirin therapy benefits many patients with aspirin-exacerbated respiratory disease but provides no benefit for aspirin-tolerant asthmatics. Type 2 inflammation characterizes aspirin-exacerbated respiratory disease.

Objective: We sought to determine whether high-dose aspirin therapy changes biomarkers of type 2 inflammation in aspirin-exacerbated respiratory disease. Read More

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http://dx.doi.org/10.1164/rccm.201809-1755OCDOI Listing

Prevalence of food hypersensitivity in relation to IgE sensitisation to common food allergens among the general adult population in West Sweden.

Clin Transl Allergy 2019 1;9:22. Epub 2019 Apr 1.

2Department of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The prevalence of self-experienced adverse reactions to foods seems to have an increasing trend in both adults and children. However, it is unclear if the prevalence of food hypersensitivity in the Swedish adult population is still rising, what symptoms are caused by different foods and which are the most common foods to which adults are more frequently IgE-sensitised.

Methods: In a cross-sectional study based on questionnaire responses, interviews and clinical examinations as part of the West Sweden Asthma Study, 1042 subjects from the general population, 17-78 years of age, living in Västra Götaland, Sweden, were included. Read More

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https://ctajournal.biomedcentral.com/articles/10.1186/s13601
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http://dx.doi.org/10.1186/s13601-019-0261-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442429PMC
April 2019
2 Reads

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study.

Authors:
Ali H Ziyab

World Allergy Organ J 2019 30;12(4):100024. Epub 2019 Mar 30.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Background: Food allergy (FA) is a common public health problem that affects both children and adults. Empirical knowledge of the burden of FA in Kuwait is limited. This study sought to estimate the prevalence of FA among schoolchildren in Kuwait and assess associations between FA and the coexistence and severity of asthma, rhinitis, and eczema. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441753PMC
March 2019
1 Read

Variability in total serum IgE over 1 year in severe asthmatics.

Allergy Asthma Clin Immunol 2019 29;15:20. Epub 2019 Mar 29.

6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.

Background: Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgE) in asthmatics remains poorly documented.

Methods: In this prospective study, sIgE levels were measured over 1 year at 7 time points in 41 severe asthmatics treated with high-dose of inhaled corticosteroids and long-acting β agonists. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441212PMC
March 2019
1 Read

Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies.

Allergy Asthma Clin Immunol 2019 29;15:19. Epub 2019 Mar 29.

1Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Read More

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http://dx.doi.org/10.1186/s13223-019-0335-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441184PMC
March 2019
2 Reads

Translation and psychometric properties of the King's Sarcoidosis Questionnaire (KSQ) in German language.

Health Qual Life Outcomes 2019 Apr 11;17(1):62. Epub 2019 Apr 11.

Department of Pneumology, Faculty of Medicine, Medical Center- University of Freiburg, Freiburg, Germany.

Background: King's Sarcoidosis Questionnaire (KSQ) is a novel, validated, health-related quality of life questionnaire on sarcoidosis with 5 scales and 29 items. For future multinational observational and interventional studies on sarcoidosis, a validated German version of the KSQ is needed. The objective of our study is to translate the original KSQ and develop a German version possessing good psychometric properties and with as few modifications as possible. Read More

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http://dx.doi.org/10.1186/s12955-019-1131-zDOI Listing
April 2019
3 Reads

Changes in Emergency Department Concordance with Guidelines for the Management of Food-Induced Anaphylaxis: 1999-2001 versus 2013-2015.

J Allergy Clin Immunol Pract 2019 Apr 8. Epub 2019 Apr 8.

Massachusetts General Hospital, Boston, MA.

Background: Awareness about food allergy and food-induced anaphylaxis (FIA) has increased dramatically over the past decade. It remains unclear, however, whether concordance with guidelines for FIA management has improved over time.

Objective: Our objective was to describe changes in emergency department (ED) concordance with guidelines for FIA management. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.004DOI Listing
April 2019
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Epithelium-derived Cystatin-SN enhances eosinophil activation and infiltration via interleukin-5 in chronic rhinosinusitis with nasal polyps.

J Allergy Clin Immunol 2019 Apr 8. Epub 2019 Apr 8.

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China; Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China. Electronic address:

Background: The interaction between epithelial cells and immune cells plays an important role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP); however, the mechanism/s underlying TH-biased inflammation in this process is/are largely unknown. Profiling protein expression in CRSwNP by shotgun proteomics suggested that Cystatin SN (CST1), a type 2 cysteine protease inhibitor, may play a role, as this was expressed with greatest difference in eosinophilic (E)CRSwNP and nonECRSwNP patients.

Objectives: To investigate the expression and role of CST1 in modulating eosinophilic inflammation in CRSwNP. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.03.026DOI Listing
April 2019
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Lung Eosinophils - a Novel 'Virus Sink' that is Defective in Asthma?

Allergy 2019 Apr 10. Epub 2019 Apr 10.

Child Life and Health and Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Eosinophils represent one of the most studied cells in the development and pathophysiology of various immune mediated disorders and conditions. Moreover, they serve as important biomarkers (diagnostic, therapy-driving, prognostic) in daily allergy praxis and can be affected by several therapeutic interventions. Eosinophils differentiate from a pluripotent progenitor under the influence of several cytokines and growth factors. Read More

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http://dx.doi.org/10.1111/all.13811DOI Listing
April 2019
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Commentary: Treating Pediatric Asthma According Guidelines.

Front Pediatr 2019 27;7:109. Epub 2019 Mar 27.

Klinik für Kinder- und Jugendmedizin, Evangelisches Klinikum Bethel, Bielefeld, Germany.

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http://dx.doi.org/10.3389/fped.2019.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446829PMC

Selection of biologics in severe asthma: a multifaceted algorithm.

J Investig Allergol Clin Immunol 2019 Apr 10. Epub 2019 Apr 10.

Department of Allergy, Hospital La Paz Institute for Health Research (IdIPAZ), Madrid (Spain), and CIBER of Respiratory Diseases (CIBERES).

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http://dx.doi.org/10.18176/jiaci.0398DOI Listing

Asthma control test reflects not only lung function but also airway inflammation in children with stable asthma.

J Asthma 2019 Apr 10:1-6. Epub 2019 Apr 10.

a Department of Pediatrics, School of Medicine , The Catholic University of Korea , Bucheon St. Mary's Hospital , Bucheon , Korea.

Objective: Various numerical asthma control tools have been developed to distinguish different levels of symptom control. We aimed to examine whether the asthma control test (ACT) is reflective of objective findings such as lung function, fractional exhaled nitric oxide (FeNO) and laboratory data in patients with stable asthma.

Methods: We included patients who were enrolled in the Korean Childhood Asthma Study. Read More

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http://dx.doi.org/10.1080/02770903.2019.1599386DOI Listing
April 2019
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Linking COPD epidemiology with pediatric asthma care; implications for the patient and the physician.

Pediatr Allergy Immunol 2019 Apr 10. Epub 2019 Apr 10.

Translational Medicine, Hospital for Sick Children, Toronto, Canada.

A 10-year-old patient with asthma, diagnosed in early childhood, with a pre-bronchodilator forced expiratory volume in 1 second (FEV1) of 75% of predicted attends a routine follow-up visit. The patient and family perceive his asthma as 'well controlled', but should his physician be concerned about his reduced lung function? What are the implications of a lower than expected FEV1 in childhood on the respiratory health of this patient in adulthood? Lung function is known to track with age, and there is a high likelihood that this patient will enter adulthood with a sub-optimal lung function. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/pai.13054DOI Listing

A Randomized Trial of human C1 inhibitor prophylaxis in children with hereditary angioedema.

Pediatr Allergy Immunol 2019 Apr 9. Epub 2019 Apr 9.

HRZM Hemophilie Center Rhein Main, Mörfelden-Walldorf, Germany.

Background: Patients with hereditary angioedema with C1 inhibitor deficiency or dysfunction have burdensome recurrent angioedema attacks. The safety, efficacy, and health-related quality of life (HRQoL) outcomes of C1 inhibitor (C1-INH) prophylaxis (intravenously administered) in patients aged 6-11 years were investigated.

Methods: Eligible patients were enrolled in a randomized, single-blind, crossover phase 3 trial. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pai.13060
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http://dx.doi.org/10.1111/pai.13060DOI Listing
April 2019
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Semaphorin 3A Is Effective in Reducing Both Inflammation and Angiogenesis in a Mouse Model of Bronchial Asthma.

Front Immunol 2019 22;10:550. Epub 2019 Mar 22.

Proteomic Unit, The Division of Clinical Immunology and Allergy, Bnai-Zion Medical Center, Haifa, Israel.

Semaphorin 3A (sema3A) belongs to the sub-family of the immune semaphorins that function as regulators of immune-mediated inflammation. Sema3A is a membrane associated molecule on T regulatory cells and on B regulatory cells. Being transiently ligated to the cell surface of these cells it is suggested to be a useful marker for evaluating their functional status. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439418PMC

Understanding Platelets in Infectious and Allergic Lung Diseases.

Int J Mol Sci 2019 Apr 8;20(7). Epub 2019 Apr 8.

Institute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of Medicine, San Pablo CEU University, 28668 Madrid, Spain.

Emerging evidence suggests that platelets, cytoplasmic fragments derived from megakaryocytes, can no longer be considered just as mediators in hemostasis and coagulation processes, but as key modulators of immunity. Platelets have received increasing attention as the emergence of new methodologies has allowed the characterization of their components and functions in the immune continuum. Platelet activation in infectious and allergic lung diseases has been well documented and associated with bacterial infections reproduced in several animal models of pulmonary bacterial infections. Read More

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https://www.mdpi.com/1422-0067/20/7/1730
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http://dx.doi.org/10.3390/ijms20071730DOI Listing
April 2019
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Clinical Insights About Topical Treatment of Mild-to-Moderate Pediatric and Adult Atopic Dermatitis.

J Cutan Med Surg 2019 Apr 9:1203475419843108. Epub 2019 Apr 9.

9 Division of Dermatology, BC Children's Hospital; University of British Columbia, Vancouver, Canada.

Atopic dermatitis (AD) is a chronic inflammatory skin condition, also referred to as atopic eczema, that is identified by itching and recurrent eczematous lesions. It often starts in infancy where it affects up to 20% of children but is also highly prevalent in adults. AD inflicts a significant psychosocial burden on patients and their families and increases the risk of other immune-mediated inflammatory conditions, such as asthma and allergic rhinitis, food allergy, and mental health disorders. Read More

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http://dx.doi.org/10.1177/1203475419843108DOI Listing
April 2019
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Thinking bigger: How early life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, British Columbia Children's Hospital, The University of British Columbia, Vancouver, BC, Canada.

Imbalance, or dysbiosis, of the gut microbiome of infants has been linked to an increased risk of asthma and allergic diseases. Most studies to date have provided a wealth of data showing correlations between early-life risk factors for disease and changes in the structure of the gut microbiome that disrupt normal immunoregulation. These studies have typically focused on one specific risk factor, such as mode of delivery or early-life antibiotic use. Read More

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http://dx.doi.org/10.1111/all.13812DOI Listing
April 2019
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Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.

J Leukoc Biol 2019 Apr 9. Epub 2019 Apr 9.

Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.

Myeloid C-type lectin receptors (CLRs), which consist of an extracellular carbohydrate recognition domain and intracellular signal transducing motif such as the immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor tyrosine-based inhibitory motif (ITIM), are innate immune receptors primarily expressed on myeloid lineage cells such as dendritic cells (DCs) and Mϕs. CLRs play important roles in host defense against infection by fungi and bacteria by recognizing specific carbohydrate components of these pathogens. However, these immune receptors also make important contributions to immune homeostasis of mucosa and skin in mammals by recognizing components of microbiota, as well as by recognizing self-components such as alarmins from dead cells and noncanonical non-carbohydrate ligands. Read More

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http://dx.doi.org/10.1002/JLB.2RI0119-031RDOI Listing

Legends of Allergy: Stephen J. Galli.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA.

Professor Stephen J. Galli's rigorous and innovative research in the field of allergy and immunology has truly made him a legend in the field. His accomplishments are many as are the awards and recognitions he has received. Read More

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http://dx.doi.org/10.1111/all.13815DOI Listing