463,579 results match your criteria Allergy and asthma proceedings : the official journal of regional and state allergy societies[Journal]


Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy.

J Pharm Biomed Anal 2019 Apr 9;172:1-8. Epub 2019 Apr 9.

Jack Jumper Allergy Program, Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania, 7001, Australia; School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia.

A major challenge in broader clinical application of Jack Jumper ant venom immunotherapy (JJA VIT) is the scarcity of ant venom which needs to be manually harvested from wild ants. Adjuvants are commonly used for antigen sparing in other vaccines, and thereby could potentially have major benefits to extend JJA supplies if they were to similarly enhance JJA VIT immunogenicity. The purpose of this study was to evaluate the physicochemical and microbiological stability and murine immunogenicity of low-dose JJA VIT formulated with a novel polysaccharide adjuvant referred to as delta inulin or Advax™. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.017DOI Listing

Impaired learning from punishment of errors in smokers: Differences in dorsolateral prefrontal cortex and sensorimotor cortex blood-oxygen-level dependent responses.

Neuroimage Clin 2019 Apr 8;23:101819. Epub 2019 Apr 8.

School of Psychological Sciences, University of Melbourne, 12th floor Redmond Barry Building, Parkville Campus, Melbourne, VIC 3010, Australia. Electronic address:

Cigarette smokers have shown hypersensitivity to reward and hyposensitivity to punishment, along with impairments in learning from errors. The underlying neural mechanism for this failure to adapt performance following an error, particularly when receiving negative feedback, are unclear. Smokers were hypothesized to have poorer error-learning following monetary punishment, associated with hypoactivation in the insula, dorsal anterior cingulate, and hippocampal cortical regions. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101819DOI Listing

Cost-effective care in eosinophilic esophagitis.

Authors:
Evan S Dellon

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.010DOI Listing

Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Pediatric Pneumology and Allergology unit, Necker-Enfants Malades Hospital, Paris, France; Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1016/j.anai.2019.04.011DOI Listing

Acute Care Beta-Lactam Allergy Pathways: Approaches and Outcomes.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.009DOI Listing

Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

Matrix metalloproteinase-12 produced by Ly6C macrophages prolongs the survival after myocardial infarction by preventing neutrophil influx.

J Mol Cell Cardiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Background: Various immune cells are involved in different phases of cardiac repair after myocardial infarction (MI). Especially, Ly6C M2-like macrophages (Ly6C macrophages) are vital for cardiac repair after MI. However, the molecular mechanisms how Ly6C macrophages promote wound healing after MI are still largely unknown. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.007DOI Listing

Prevalence and associated factors of skin cancer in aged nursing home residents: A multicenter prevalence study.

PLoS One 2019 22;14(4):e0215379. Epub 2019 Apr 22.

Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Germany.

Non-melanoma-skin cancer is an emerging clinical problem in the elderly, fair skinned population which predominantly affects patients aged older than 70 years. Its steady increase in incidence rates and morbidity is paralleled by related medical costs. Despite the fact that many elderly patients are in need of care and are living in nursing homes, specific data on the prevalence of skin cancer in home care and the institutional long-term care setting is currently lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215379PLOS

Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in psoriasis patients treated up to 5 years.

J Eur Acad Dermatol Venereol 2019 Apr 22. Epub 2019 Apr 22.

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Background: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A, a key cytokine involved in psoriasis (PsO) and psoriatic arthritis (PsA) development, and has shown rapid and long lasting efficacy and safety in the complete spectrum of psoriasis manifestations. Monoclonal antibody therapies may be associated with the production of treatment-emergent anti-drug antibodies (TE-ADA) that can affect drug pharmacokinetics, diminish clinical responses via inhibition of target binding, or cause hypersensitivity reactions. Secukinumab exhibited minimal immunogenicity up to 52 weeks in patients with moderate-to-severe plaque psoriasis, as evidenced by TE-ADA in <1% patients. Read More

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http://dx.doi.org/10.1111/jdv.15637DOI Listing

Epigenome Wide Association Studies in Asthma: A Systematic Review.

Clin Exp Allergy 2019 Apr 22. Epub 2019 Apr 22.

Department of Bioanalysis, Faculty of pharmaceutical sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent.

Objective: Asthma is a common, chronic respiratory airway disease influenced by environmental factors and possibly their interaction with the human genome causing epigenetic changes. Epigenome wide association studies (EWAS) have mainly investigated DNA methylation and its association with disease or traits, exposure factors or gene expression. This systematic review aimed to identify all EWAS assessing differentially methylated sites associated with asthma in humans. Read More

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http://dx.doi.org/10.1111/cea.13403DOI Listing

Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: A retrospective study.

Medicine (Baltimore) 2019 Apr;98(16):e15275

Department of Emergency Medicine, Beijing Chao-yang Hospital.

Severity stratification and prognostic prediction at early stage is crucial for reducing the rates of mortality of patients with acute pancreatitis (AP). We aim to investigate the predicting performance of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red-cell distribution width (RDW) combined with severity scores (sequential organ failure assessment [SOFA], bed-side index for severity of AP [BISAP], Ranson criteria, and acute physiology and chronic health evaluation II [APACHE II]) for severe AP (SAP) and mortality.A total of 406 patients diagnosed with AP admitted in a tertiary teaching hospital were enrolled. Read More

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http://dx.doi.org/10.1097/MD.0000000000015275DOI Listing

Burnout: Going beyond mindfulness to NP-led interprofessional teams.

Nurse Pract 2019 May;44(5):10-12

Susan J. Corbridge is an associate dean of practice and partnerships, College of Nursing, and clinical associate professor, College of Nursing and Department of Medicine, Division of Pulmonary, Critical Care, Sleep & Allergy at the University of Illinois at Chicago, Chicago, Ill. Sheila Melander is an associate dean of MSN and DNP faculty and practice affairs at the University of Kentucky College of Nursing, Lexington, KY.

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http://dx.doi.org/10.1097/01.NPR.0000554681.87353.2dDOI Listing
May 2019
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Increasing Rates of Diagnosis, Substantial Co-Occurrence, and Variable Treatment Patterns of Eosinophilic Gastritis, Gastroenteritis, and Colitis Based on 10-Year Data Across a Multicenter Consortium.

Am J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objectives: The literature related to eosinophilic gastritis (EG), gastroenteritis (EGE), and colitis (EC) is limited. We aimed to characterize rates of diagnosis, clinical features, and initial treatments for patients with EG, EGE, and EC.

Methods: In this retrospective study, data were collected from 6 centers in the Consortium of Eosinophilic Gastrointestinal Researchers from 2005 to 2016. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000228DOI Listing

Resolution of cutaneous sarcoidosis after Janus kinase inhibitor therapy for concomitant polycythemia vera.

JAAD Case Rep 2019 Apr 5;5(4):360-361. Epub 2019 Apr 5.

University of Pennsylvania Perelman School of Medicine, Department of Dermatology, Philadelphia, Pennsylvania.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126193005
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http://dx.doi.org/10.1016/j.jdcr.2019.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453827PMC
April 2019
1 Read

Report of a rare case of severe allergic reaction due to nasal myiasis and a brief review of the literature in Turkey.

SAGE Open Med Case Rep 2019 10;7:2050313X19843390. Epub 2019 Apr 10.

Department of Clinical Microbiology, School of Medicine, Hitit University, Çorum, Turkey.

Myiasis is defined as infestation of a mammal by fly larvae. It may occur on either living tissues (primary myiasis) or dead tissues (secondary myiasis). In this report, we present a patient with myiasis with an extremely rare clinical manifestation and severe allergic reaction, and we review the literature in order to reveal the current status. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X19843390
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http://dx.doi.org/10.1177/2050313X19843390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458663PMC
April 2019
1 Read

Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.

Clin Transl Allergy 2019 10;9:24. Epub 2019 Apr 10.

3Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Read More

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http://dx.doi.org/10.1186/s13601-019-0262-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456961PMC

Study of Nickel Levels in Patients with Atrial Septal Defect Undergoing Amplatzer Device Closure.

Heart Views 2018 Jul-Sep;19(3):85-87

Department of Cardiology, Grant Medical College, Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.

Transcatheter closure of atrial septal defects (ASDs) using nickel titanium Naval Ordnance Laboratory (Nitinol)-containing devices (Amplatzer, AGA Medical, Golden Valley, Minnetosa) is being widely practiced. Controversies still exist regarding the release of nickel from these devices and the allergy and other ill effects of nickel and also the duration of antiplatelet therapy to aid endothelization of the device.

Objective: To study the nickel levels in patients who underwent ASD closure with platinum-coated Nitinol-containing Amplatzer septal occluder. Read More

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http://dx.doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_76_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448472PMC

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

The Role of Relaxin-2 in Tissue Remodeling of Chronic Rhinosinusitis With Nasal Polyps.

Am J Rhinol Allergy 2019 Apr 22:1945892419843828. Epub 2019 Apr 22.

1 Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Relaxin is a small peptide hormone that regulates extracellular matrix remodeling and reduces fibrosis in a number of organs. Little is known about its impact on chronic rhinosinusitis with nasal polyps (CRSwNP); thus, we aimed to determine the expression of human H2 relaxin (relaxin-2) and its role in tissue remodeling in CRSwNP.

Methods: Patients were enrolled and divided into the following groups: CRS with NP (CRSwNP; n = 20), CRS without NP (CRSsNP; n = 20), and controls (n = 15). Read More

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http://dx.doi.org/10.1177/1945892419843828DOI Listing

Leukotriene Receptor Antagonist Addition to H1-Antihistamine Is Effective for Treating Allergic Rhinitis: A Systematic Review and Meta-analysis.

Am J Rhinol Allergy 2019 Apr 22:1945892419844459. Epub 2019 Apr 22.

1 Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Histamine and leukotriene are released after being triggered by allergen exposure. The combination of leukotriene receptor antagonist (LTRA) and H1-antihistamine (AH) is utilized to control the allergic rhinitis (AR) symptoms after the failure of either AH or LTRA.

Objective: This study aimed to investigate the effects of the combination of H1-antihistamine and leukotriene receptor antagonist (AH-LTRA) in patients with AR. Read More

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http://dx.doi.org/10.1177/1945892419844459DOI Listing

[Allergen-derived peptide: A promising approach in asthma].

Rev Mal Respir 2019 Apr 18. Epub 2019 Apr 18.

Inra, UR 1268 BIA, 44316 Nantes, France. Electronic address:

Severe asthma required high dose of corticosteroids combined with biotherapies to control more or less asthma symptoms and lead to the decrease of patients' quality of life on long term. Recent studies show that hypoallergenic peptides derived from allergen can prevent airway hyperresponsiveness, decrease Th2 response and also allergen-specific IgE in mouse models of allergic asthma. Even if some peptides mechanisms remain unknown, their fast efficacy with low doses of allergens make peptide immunotherapy a new promising approach in allergic asthma. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.03.005DOI Listing

Serum galectin-1, galectin-3 and galectin-9 are bystander molecules for chronic spontaneous urticaria.

Allergy 2019 Apr 21. Epub 2019 Apr 21.

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China, 510120.

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http://dx.doi.org/10.1111/all.13835DOI Listing

Oral allergen immunotherapy by targeting Peyer's patches.

Allergy 2019 Apr 21. Epub 2019 Apr 21.

Comparative Medicine, The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Veterinärplatz 1, A-1210, Vienna, Austria.

The present patent relates to the use of bioadhesive, biodegradable poly-lacto-glycolic (PLGA) microparticles for allergen immunotherapy. Surface modification of allergen-loaded microspheres with Aleuria aurantia lectin causes selective enrichment, prolongation of the dwell time and uptake via mucosal M cells overlying the lymph nodes e.g. Read More

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http://dx.doi.org/10.1111/all.13828DOI Listing

Increased expression of IL-24 in chronic spontaneous urticaria.

Allergy 2019 Apr 21. Epub 2019 Apr 21.

de Duve Institute, Université catholique de Louvain, Brussels, Belgium.

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http://dx.doi.org/10.1111/all.13832DOI Listing

Novel clinical scores for occupational asthma due to exposure to high-molecular-weight agents.

Occup Environ Med 2019 Apr 20. Epub 2019 Apr 20.

Centre de Recherche, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

Objective: Specific inhalation challenge (SIC) as the reference diagnostic test for occupational asthma (OA) is not widely available worldwide. We aimed to develop non-SIC-based models for OA.

Methods: Of 427 workers who were exposed to high-molecular-weight agents and referred to OA clinic at Montréal Sacré-Cœur Hospital between 1983 and 2016, we analysed 160 workers who completed non-specific bronchial hyper-responsiveness (NSBHR) tests and still worked 1 month before SIC. Read More

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http://dx.doi.org/10.1136/oemed-2018-105593DOI Listing

Ofatumumab is safe and effective as front-line treatment in older patients with chronic lymphocytic leukemia and severe co-morbidities, including other malignancies.

J Geriatr Oncol 2019 Apr 17. Epub 2019 Apr 17.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: The majority of patients with chronic lymphocytic leukemia (CLL) are older and have multiple comorbidities, including other cancer diagnoses. These patients are routinely excluded from participation in clinical trials.

Objective: In this phase II study, we determined the activity and toxicity of ofatumumab, a fully human anti-CD20 monoclonal antibody, in older patients with CLL, poor performance status and comorbidities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18794068193003
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http://dx.doi.org/10.1016/j.jgo.2019.04.002DOI Listing
April 2019
1 Read

Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins.

Trends Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Current international guidelines for the risk assessment of biotechnology-derived foods date back to 2003. We present new strategies and directions for assessing immune adverse reactions to novel food proteins. Understanding genetic factors involved in food allergy and the role of the gastrointestinal tract will streamline risk assessment strategies. Read More

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http://dx.doi.org/10.1016/j.tibtech.2019.03.010DOI Listing

Imiquimod enhances DNFB mediated contact hypersensitivity in mice.

Int Immunopharmacol 2019 Apr 17;72:284-291. Epub 2019 Apr 17.

Department of Immunology, Basic Medical College of Qingdao University, Qingdao 266071, China.

Imiquimod (Imiq) is a synthetic imizoquinoline compound which can act on Toll-like receptor (TLR)7 and transduce signals involved in cell activation. We investigated the role of Imiq on contact hypersensitivity (CHS) and explored the potential mechanisms of mast cells involved in the process. Topical application of Imiq cream augmented DNFB mediated CHS in C57BL/6 mice. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.025DOI Listing
April 2019
1 Read

Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Immunology Section, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address:

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. Read More

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http://dx.doi.org/10.1016/j.parint.2019.04.015DOI Listing

Assessing laryngeal function and hypersensitivity.

Pulm Pharmacol Ther 2019 Apr 17. Epub 2019 Apr 17.

Department of Respiratory Medicine, Royal Brompton Hospital, London, SW3 6HP, UK. Electronic address:

The larynx is one of the most highly innervated organs in humans, adapted to simultaneously deliver several key respiratory functions including airway protection, swallowing and phonation. In some individuals the larynx can adopt a state that could be considered 'dysfunctional' or maladaptive; resulting in or contributing to a range of clinical disorders such as chronic refractory cough, inducible laryngeal obstruction (previously termed paradoxical vocal fold movement or vocal cord dysfunction), muscle tension dysphonia and globus pharyngeus. These disorders appear to display significant overlap in clinical symptomology and in many cases have features of concomitant or allied sensory dysfunction; often described as laryngeal hypersensitivity. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.04.003DOI Listing

Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells.

Immunol Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Medicine, Aarhus University, Denmark. Electronic address:

IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releasability of basophils. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.04.003DOI Listing

Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing
April 2019
2 Reads

Maternal Triacylglycerol Signature and Offspring Risk of Food Allergy.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Background: The prevalence of IgE-mediated food allergy (FA) is rising worldwide but the underlying mechanisms are poorly understood.

Objective: To examine the role of maternal lipidomic profiles in offspring risk of FA development; and to investigate the potential modification effects by timing of first solid food introduction.

Methods: This report included 1,068 mother-child dyads from the Boston Birth Cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.03.033DOI Listing
April 2019
1 Read

Repressive role of stabilized HIF1α expression on TGFβ-induced extracellular matrix production in lung cancer cells.

Cancer Sci 2019 Apr 20. Epub 2019 Apr 20.

Department of Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Activation of transforming growth factor β (TGFβ) combined with persistent hypoxia are often affecting the tumor microenvironment. Disruption of cadherin/catenin complexes induced by these stimulations yields aberrant extracellular matrix (ECM) production, characteristics of an epithelial-mesenchymal transition (EMT). Hypoxia-inducible factors (HIFs), the hallmark of the response to hypoxia, play differential roles during development of diseases. Read More

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http://dx.doi.org/10.1111/cas.14027DOI Listing

What did we learn from multiple omics studies in asthma?

Allergy 2019 Apr 20. Epub 2019 Apr 20.

Department of Respiratory Medicine, Amsterdam University Medical Centres, (AUMC), University of Amsterdam, Amsterdam, The Netherlands.

More than a decade has passed since the finalisation of the Human Genome Project. Omics technologies made a huge leap from trendy and very expensive to routinely executed and relatively cheap assays. Simultaneously, we understood that omics is not a panacea for every problem in the area of human health and personalized medicine. Read More

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http://dx.doi.org/10.1111/all.13833DOI Listing

Endothelial B2-receptor overexpression as an alternative animal model for hereditary angioedema.

Allergy 2019 Apr 20. Epub 2019 Apr 20.

Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125, Berlin, Germany.

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http://dx.doi.org/10.1111/all.13836DOI Listing

The allergen-specificity of allergen immunotherapy - doubt no more.

Authors:
Stephen R Durham

Allergy 2019 Apr 20. Epub 2019 Apr 20.

National Heart and Lung Institute, Imperial College London, Dovehouse Street, London.

The ARIA-GA2LEN collaboration published a guide for the design and evaluation of randomised controlled trials of allergen immunotherapy for allergic rhinitis. Several problems in were identified. For example, the severity/persistence of seasonal symptoms in subjects during allergen immunotherapy was noted to be much lower than in trials of pharmacotherapy. Read More

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http://dx.doi.org/10.1111/all.13826DOI Listing

A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder.

J Autism Dev Disord 2019 Apr 19. Epub 2019 Apr 19.

Massachusetts General Hospital, Boston, MA, USA.

Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to sensory stimuli make participating in neuroimaging studies challenging for individuals with ASD. In this commentary, we describe the existent training protocols for preparing individuals with ASD for PET/MRI scans and our own experience developing a training protocol to facilitate the inclusion of low-functioning adults with ASD in PET-MRI studies. Read More

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http://link.springer.com/10.1007/s10803-019-04010-3
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http://dx.doi.org/10.1007/s10803-019-04010-3DOI Listing
April 2019
1 Read

Pro- and anti-inflammatory eicosanoids in psoriatic arthritis.

Metabolomics 2019 Apr 19;15(4):65. Epub 2019 Apr 19.

Department of Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, San Diego, CA, 92093, USA.

Introduction: Eicosanoids are biological lipids that serve as both activators and suppressors of inflammation. Eicosanoid pathways are implicated in synovitis and joint destruction in inflammatory arthritis, yet they might also have a protective function, underscoring the need for a comprehensive understanding of how eicosanoid pathways might be imbalanced. Until recently, sensitive and scalable methods for detecting and quantifying a high number of eicosanoids have not been available. Read More

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http://dx.doi.org/10.1007/s11306-019-1527-0DOI Listing

Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago.

Lung 2019 Apr 19. Epub 2019 Apr 19.

Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, Department of Medicine (M/C 719), University of Illinois at Chicago, 840 South Wood Street, Chicago, IL, 60612, USA.

A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that were mixed with Spice/K2 products procured and then inhaled by the victims. We report on 3 poisoned patients who reside in underserved, socioeconomically disadvantaged neighborhoods of Chicago that were admitted and treated successfully at two inner-city, tertiary care hospitals in Chicago. Read More

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http://dx.doi.org/10.1007/s00408-019-00227-2DOI Listing

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine.

Sci Immunol 2019 Apr;4(34)

HIV-Specific Immunity Section of the Laboratory of Immunoregulation, National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and influenza. Here, we report the dynamics of B cell expansion and evolution at the single-cell level after vaccination with a replication-competent adenovirus type 4 recombinant virus expressing influenza H5 hemagglutinin. Fluorescent H1 or H5 probes were used to quantitate and isolate peripheral blood B cells and their antigen receptors. Read More

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http://dx.doi.org/10.1126/sciimmunol.aau2710DOI Listing

Epitope mapping of antibodies induced with a conserved rhinovirus protein generating protective anti-rhinovirus immunity.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, London, UK; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and chronic obstructive pulmonary disease (COPD) exacerbations. Currently there is no vaccine for RV which is largely due to the existence of ∼160 serotypes/strains. We demonstrated previously that immunising mice with highly conserved VP4 and VP2 regions of the RV polyprotein (RV-A16 VP0) generated cross-reactive immunity to RV in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193045
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http://dx.doi.org/10.1016/j.vaccine.2019.04.018DOI Listing
April 2019
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Process of immunogenic cell death caused by disulfiram as the anti-colorectal cancer candidate.

Biochem Biophys Res Commun 2019 Apr 16. Epub 2019 Apr 16.

Department of Immunology, School of Life Sciences and Biopharmaceuticals Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Guangdong Engineering & Technology Research Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Digital Quality Evaluation of Chinese Medical of State Administration of TCM, Guangzhou, 510006, PR China. Electronic address:

Background: Disulfiram (DSF), a drug widely used to control alcoholism, which has anticancer activity by inducing apoptosis in a copper (Cu)-dependent manner. Numerous evidences from mouse experiments indicated that some anti-cancer agents of chemotherapeutic drugs favor the induction of immunogenic cancer cell death (ICD) leading to tumor-specific immune responses. However, whether DSF could induce the colorectal tumor cells death and the mechanism involved in ICD regulatory remains elusive. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.192DOI Listing
April 2019
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Pain Relieving Effect of-NSAIDs-CAIs Hybrid Molecules: Systemic and Intra-Articular Treatments against Rheumatoid Arthritis.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Gaetano Pieraccini 6, 50139 Florence, Italy.

To study new target-oriented molecules that are active against rheumatoid arthritis-dependent pain, new dual inhibitors incorporating both a carbonic anhydrase (CA)-binding moiety and a cyclooxygenase inhibitor (NSAID) were tested in a rat model of rheumatoid arthritis induced by CFA intra-articular (i.a.) injection. Read More

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http://dx.doi.org/10.3390/ijms20081923DOI Listing