486,186 results match your criteria Allergy and asthma proceedings : the official journal of regional and state allergy societies[Journal]


[From a trail to an official path: new recommendations for the treatment of mild asthma].

Authors:
Marek Lommatzsch

Dtsch Med Wochenschr 2020 Jun 3;145(11):767-771. Epub 2020 Jun 3.

Abteilung für Pneumologie/Interdisziplinäre Internistische Intensivstation, Medizinische Klinik I, Zentrum für Innere Medizin, Universitätsmedizin Rostock.

Accumulating evidence suggests that a symptom-driven therapy with fixed combinations of inhaled corticosteroids (ICS) and formoterol is safer and more feasible in patients with mild asthma than a treatment with short-acting beta-2-agonists (SABA) alone. Therefore, the new international GINA asthma guideline (2019) recommends, for the first time, as needed low dose ICS-formoterol as the preferred controller in treatment step 1. This radical paradigm shift will have a major impact on asthma care in the future. Read More

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http://dx.doi.org/10.1055/a-1003-7142DOI Listing

[Case report of contact allergy to filtering facepiece class 2 mask of a medical worker during Covid-19 pandemic].

Laryngorhinootologie 2020 Jun 3. Epub 2020 Jun 3.

Hals-Nasen-Ohrenklinik und Poliklinik, Universitätsmedizin Mainz.

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http://dx.doi.org/10.1055/a-1189-6301DOI Listing

Necroptosis inhibition prevents long-term cardiac damage during pneumococcal pneumonia and invasive disease.

J Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

Department of Microbiology, The University of Alabama at Birmingham, Birmingham, USA.

Background: Streptococcus pneumoniae (Spn) infection can result in bacteremia with devastating consequences including heart damage. Necroptosis is a pro-inflammatory form of cell death instigated by pore-forming toxins such as Spn pneumolysin. Necroptosis-inhibiting drugs may lessen organ damage during invasive pneumococcal disease (IPD). Read More

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http://dx.doi.org/10.1093/infdis/jiaa295DOI Listing

Phenotypic and Functional Analysis of T Follicular Cells in Common Variable Immunodeficiency.

Int Arch Allergy Immunol 2020 Jun 3:1-13. Epub 2020 Jun 3.

Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, Irvine, California, USA.

Introduction: One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study was to evaluate the role of circulating T follicular helper (cTFH) and circulating T follicular regulatory (cTFR) cells in the pathogenesis of CVID.

Methods: cTFH and cTFR cells from CVID patients and healthy subjects were phenotypically characterized by flow cytometry. Read More

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http://dx.doi.org/10.1159/000507995DOI Listing

Eating fish and fruits are associated with lower prevalence of allergic diseases.

Respir Med Res 2020 May 12;78:100761. Epub 2020 May 12.

Epicene Inserm Bordeaux, Laboratory - work health Environment, Institute of Public Health, Epidemiology and Development, University Bordeaux Segalen, 33076 Bordeaux, France. Electronic address:

Background: Allergic diseases are recognized as a burden on the public health. They stand as one of the most common chronic diseases, especially in developed countries. Therefore, the objective of this study is to evaluate the association between the development of atopic allergy and the presence of food allergy in children, and food consumption. Read More

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http://dx.doi.org/10.1016/j.resmer.2020.100761DOI Listing

Treating COVID-19 with colchicine in community healthcare setting.

Clin Immunol 2020 May 31:108490. Epub 2020 May 31.

Unit of General Medicine and Advanced Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.clim.2020.108490DOI Listing

Oral Anticoagulants and Antiplatelet Agents in Patients With Atrial Fibrillation and Concomitant Critical Limb Ischemia: A Nationwide Cohort Study.

Can J Cardiol 2020 Feb 19. Epub 2020 Feb 19.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Background: Evidence of clinical outcomes for oral anticoagulants and antiplatelet treatment (APT) in patients with atrial fibrillation (AF) and critical limb ischemia (CLI) is very limited.

Methods: In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, 1223 patients with AF and CLI taking direct-acting oral coagulants (DOACs), warfarin, or APT were identified from June 1, 2012, to December 31, 2017. We used propensity score stabilized weighting (PSSW) to balance covariates across study groups. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.02.071DOI Listing
February 2020

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Ann Am Thorac Soc 2020 Jun 3. Epub 2020 Jun 3.

Vanderbilt University Medical Center, 12328, Emergency Medicine, Nashville, Tennessee, United States.

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document provides the rationale and background for the trial and highlights key design features. We discuss five novel challenges to the design and conduct of a large, multi-center, randomized trial during a pandemic, including: 1) widespread, off-label use of the study drug before the availability of safety and efficacy data; 2) the need to adapt traditional procedures for documentation of informed consent during an infectious pandemic; 3) developing a flexible and robust Bayesian analysis incorporating significant uncertainty about the disease, outcomes, and treatment; 4) obtaining indistinguishable drug and placebo without delaying enrollment; and 5) rapidly obtaining administrative and regulatory approvals. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202005-478SDDOI Listing

Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.

Eur J Neurosci 2020 Jun 3. Epub 2020 Jun 3.

Department of Integrative Biology and Physiology, UCLA, Terasaki Life Science Building, 610 Charles E. Young Drive East, Los Angeles, CA, 90095-7239, USA.

Mice missing either Reelin or Disabled-1 (Dab1) exhibit dorsal horn neuronal positioning errors and display heat hypersensitivity and mechanical insensitivity. Reelin binds its receptors, Apolipoprotein E receptor 2 and Very-low-density lipoprotein receptor, leading to the recruitment and phosphorylation of Dab1 and activation of downstream pathways that regulate neuronal migration. Previously, we reported that 70% of Dab1 laminae I-II neurons co-expressed LIM homeobox transcription factor 1 beta (Lmx1b). Read More

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http://dx.doi.org/10.1111/ejn.14847DOI Listing

Efficacy and Safety of Abrocitinib in Patients With Moderate-to-Severe Atopic Dermatitis: A Randomized Clinical Trial.

JAMA Dermatol 2020 Jun 3. Epub 2020 Jun 3.

Pfizer Inc, Groton, Connecticut.

Importance: Abrocitinib, an oral, once-daily Janus kinase 1 selective inhibitor, was effective and well tolerated in a phase 3 monotherapy trial of patients with moderate-to-severe atopic dermatitis (AD).

Objective: To investigate the efficacy and safety of abrocitinib in adolescents and adults with moderate-to-severe AD in an identically designed trial.

Design, Setting, And Participants: This phase 3, double-blinded, placebo-controlled, parallel-group randomized clinical trial included patients 12 years or older with a clinical diagnosis of moderate-to-severe AD for at least 1 year and inadequate response to topical medications given for at least 4 weeks within 6 months. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.1406DOI Listing

COVID-19 mortality rates in the European Union, Switzerland, and the UK: effect of timeliness, lockdown rigidity, and population density.

Minerva Med 2020 Jun 2. Epub 2020 Jun 2.

Hospital Universitario de la Princesa, Madrid, Spain -

Background: To date the European experience with COVID-19 mortality has been different to the observed in China and Asia. We aimed to forecast mortality trends in the 27 countries of the European Union (EU), plus Switzerland and the United Kingdom (UK), where lockdown dates and confinement interventions have been heterogeneous, and to explore its determinants.

Methods: We have adapted our predictive model of COVID-19-related mortality, which rested on the observed mortality within the first weeks of the outbreak and the date of the respective lockdown in each country. Read More

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http://dx.doi.org/10.23736/S0026-4806.20.06702-6DOI Listing

Cut-off values to evaluate exercise-induced asthma in eucapnic voluntary hyperventilation test for children.

Clin Physiol Funct Imaging 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Backround And Aim: The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise-induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remains limited. Our aim was to investigate EVH testing feasibility among children, diagnostic testing cutoff values, and which factors affect testing outcomes.

Methods: We recruited 134 patients aged 10-16 years with a history of exercise-induced dyspnea and 100 healthy control children to undergo 6-minute EVH testing. Read More

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http://dx.doi.org/10.1111/cpf.12647DOI Listing

Negative oral provocation test with porcine pancreatic enzyme plus cofactors despite confirmed α-Gal syndrome.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Dermatology and Allergy Biederstein, School of Medicine, Technische Universität München, Germany.

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http://dx.doi.org/10.18176/jiaci.0513DOI Listing

Prenatal exposure to endocrine disrupting chemicals and asthma and allergic diseases.

Authors:
M Casas M Gascon

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

ISGlobal, Barcelona, Spain.

Endocrine-disrupting chemicals (EDCs), chemicals that can interfere with endogenous hormones and that are present in many consumer products, can affect the development and functions of the immune system. The prenatal period is critical because exposure to EDCs can induce irreversible changes in the immune system and increase the susceptibility of asthma and allergies later in life. Non-persistent EDCs are of most concern due to their high annual production and potential toxicity. Read More

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http://dx.doi.org/10.18176/jiaci.0580DOI Listing

Rectal Drug formulations´ induced anaphylaxis.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Allergy. Complejo Hospitalario de Navarra.

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http://dx.doi.org/10.18176/jiaci.0584DOI Listing

Anaphylaxis Due to Senna (Cassia Angustifolia).

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Allergy Service, Hospital Universitario Cruces, 48903 Baracaldo, Bilbao, Spain.

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http://dx.doi.org/10.18176/jiaci.0608DOI Listing

IgE hypersensitivity mediated to lysine clonixinate.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Allergy Department, University Hospital Puerta de Hierro, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0613DOI Listing

Approach to occupational contact dermatitis in an industrialized region of Spain.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Department of Allergy and Clinical Immunology, Clínica Universidad de Navarra. Pamplona. Spain.

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http://dx.doi.org/10.18176/jiaci.0576DOI Listing

Quail´s egg anaphylaxis with tolerance to hen´s egg: a work-related case.

J Investig Allergol Clin Immunol 2020 Jun 3. Epub 2020 Jun 3.

Allergy and Clinical Immunology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal.

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http://dx.doi.org/10.18176/jiaci.0507DOI Listing

The influence of weather conditions on osteoarthritis and joint pain after prosthetic surgery.

Acta Orthop Belg 2020 Mar;86(1):1-9

The purpose of this narrative review was to highlight the research on the influence of weather conditions on patients with osteoarthritis, the pathophysiological mechanisms and the therapeutic consequences. A search was conducted using the Pubmed, Medline and Web of Science databases. Barometric pressure, temperature and humidity are the weather conditions that are found to be correlated most to the worsening of pain complaints. Read More

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Role of recombinant Aspergillus fumigatus antigens in diagnosing Aspergillus sensitization among asthmatics.

Mycoses 2020 Jun 3. Epub 2020 Jun 3.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: The diagnosis of Aspergillus-sensitized asthma (ASA) and allergic bronchopulmonary aspergillosis (ABPA) is made using IgE against crude antigens of A.fumigatus (cAsp). However, the IgE against cAsp has limitations due to cross-reactivity with other fungi. Read More

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http://dx.doi.org/10.1111/myc.13124DOI Listing

Possible Anti-inflammatory Effects of Mesenchymal Stem Cells Transplantation via Changes in CXCL8 Levels in Patients with Refractory Rheumatoid Arthritis.

Int J Mol Cell Med 2019 ;8(3):191-199

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The synovial- lining cells have been involved with rheumatoid arthritis (RA) through the secretion of various cytokines and chemokines. Increased levels of these cytokines and chemokines are seen first in the synovial and subsequently in the bloodstream of RA patients. The synovial and circulating levels of CXCL8, CXCL12, and CXCL13 are higher in the RA patients than in the healthy subjects, causing migration of immune cells to the joints, which is associated with increased joint destruction. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.3.191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241844PMC
January 2019

Something to Sweat About: Two Cases of Dupilumab-Induced Hyperhidrosis and Bromhidrosis.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720927703. Epub 2020 May 20.

Department of Pulmonary & Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Introduction: Atopic dermatitis (AD, eczema) is familial chronic inflammatory skin disease of complex etiology and increasing prevalence. Dupilumab is an IL-4 receptor subunit alpha (IL-4Rα) antagonist that is the first Food and Drug Administration-approved biological therapy for moderate-to-severe adult AD inadequately controlled with topical therapies. Adverse effects reported in the literature include injection site reactions, conjunctivitis, headache, and nasopharyngitis. Read More

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http://dx.doi.org/10.1177/2152656720927703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241203PMC

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort.

Clin Transl Allergy 2020 25;10:15. Epub 2020 May 25.

Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, 11883 Stockholm, Sweden.

Background: Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited.

Objective: To explore IgE-sensitization to common foods and airborne allergens in relation to sex over time in a population-based cohort followed up to young adulthood. Read More

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http://dx.doi.org/10.1186/s13601-020-00319-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247167PMC

Induction of humoral immune responses and inhibition of metastasis in mice by a VEGF peptide-based vaccine.

Iran J Basic Med Sci 2020 Apr;23(4):507-514

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis was determined.

Materials And Methods: With online bioinformatics tools, a fragment of the VEGF-A was selected for a peptide-based vaccine. Read More

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http://dx.doi.org/10.22038/ijbms.2020.38508.9141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239427PMC

High proviral load of human T cell lymphotropic virus type-1 facilitates coronary artery diseases.

Iran J Basic Med Sci 2020 Apr;23(4):500-506

Department of Cardiology, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Objectives: Coronary artery disease (CAD) is known as a life threatening disease, worldwide. In this study the role of HTLV-1 infection was evaluated on cardiac involvement in an endemic region of northeastern Iran.

Materials And Methods: Serologic and molecular tests for HTLV-1 infection were carried out in subjects who had coronary angiography. Read More

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http://dx.doi.org/10.22038/ijbms.2020.36317.8649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239420PMC

Dog keeping at home before and during pregnancy decreased the risk of food allergy in 1-year-old children.

Postepy Dermatol Alergol 2020 Apr 6;37(2):255-261. Epub 2020 May 6.

Department of Paediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland.

Introduction: The relationship between allergen exposure to animals in pregnancy and the development of allergic symptoms is not clear.

Aim: To evaluate the association between prenatal and postnatal exposure to pet ownership and development of atopic dermatitis, food allergy and wheezing in children at the age of 1 and 2.

Material And Methods: The mother-child pairs included in this study were part of the Polish Mother and Child Cohort. Read More

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http://dx.doi.org/10.5114/ada.2018.80584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262798PMC

Serum periostin levels in asthma patients in relation to omalizumab therapy and presence of chronic rhinosinusitis with nasal polyps.

Postepy Dermatol Alergol 2020 Apr 6;37(2):240-249. Epub 2020 May 6.

Institute of Clinical Immunology and Allergy, University Hospital in Hradec Králové, Faculty of Medicine, Charles University in Prague, Czech Republic.

Introduction: The serum periostin level is a promising biomarker of type 2- high inflammation pattern of bronchial asthma. It has been proven that serum periostin levels decrease in response to systemic and inhaled corticosteroid (ICS) therapy. However, we have only limited knowledge about changes in serum periostin levels reflecting omalizumab (OMA) treatment and other variables, such as chronic rhinosinusitis with nasal polyps (CRSwNP). Read More

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http://dx.doi.org/10.5114/ada.2020.94842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262810PMC

Effect of latanoprost on intraocular pressure, visual acuity and C-reactive protein.

Saudi J Biol Sci 2020 Jun 16;27(6):1569-1572. Epub 2020 Mar 16.

Department of Glaucoma, Jinhua Eye Hospital, Jinhua 231000, Zhejiang, China.

Objective: To investigate the effect of latanoprost on intraocular pressure (IOP), visual acuity and C-reactive protein (CRP) in patients with primary open-angle glaucoma (POAG).

Methods: A total of 163 POAG patients (266 eyes) admitted to our hospital from February 2015 to July 2017 were selected and divided into observation group (81 cases, 132 eyes, latanoprost eye drops) and control group (82 cases, 134 eyes, timolol maleate eye drops) according to different treatment plans. The clinical efficacy of the two groups after treatment was evaluated. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254158PMC

Asthma immunotherapy and treatment approaches with mesenchymal stem cells.

Immunotherapy 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatric Health & Diseases, Faculty of Health Sciences, Muğla Sıtkı Koçman University, Muğla, Turkey.

Asthma is a chronic inflammatory disease of the airways where exaggerated T helper 2 immune responses and inflammatory mediators play a role. Current asthma treatment options can effectively suppress symptoms and control the inflammatory process; however, cannot modulate the dysregulated immune response. Allergen-specific immunotherapy is one of the effective treatments capable of disease modification. Read More

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http://dx.doi.org/10.2217/imt-2019-0194DOI Listing

Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders.

Am J Addict 2020 Jun 2. Epub 2020 Jun 2.

Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.

Background And Objectives: In this secondary analysis of a pilot clinical trial with individuals with alcohol and nicotine use disorders, we investigate the relationship between serum concentrations of oxytocin, β-endorphin, melatonin, α-melanocyte-stimulating hormone, substance P, and orexin, with objective biomarkers (salivary cotinine and serum γ-glutamyl transferase [GGT]) as well as with self-reported smoking and alcohol drinking.

Methods: Biomarkers for a total of N = 19 participants were analyzed using multiplexed, competitive format immune-assay (peptides) and enzyme competitive immunoassay (saliva). A regression analysis using Pearson's correlation coefficient was utilized to determine correlations. Read More

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http://dx.doi.org/10.1111/ajad.13064DOI Listing

Cardiac magnetic resonance in cocaine-induced myocardial damage: cocaine, heart, and magnetic resonance.

Heart Fail Rev 2020 Jun 2. Epub 2020 Jun 2.

Fondazione Toscana Gabriele Monasterio, Via Giuseppe Moruzzi, 156124, Pisa, Italy.

The use of cocaine constitutes a major health problem. Cocaine use is associated with acute and chronic complications that might involve any system, the most common being the cardiovascular system. The precise incidence of cocaine-induced cardiomyopathy remains mysterious and probably underreported. Read More

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http://dx.doi.org/10.1007/s10741-020-09983-3DOI Listing

Occupational Skin Cancer in a Crematory Operator.

Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte Hospitalsvej 15, DK-2900 Hellerup, Denmark.

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http://dx.doi.org/10.2340/00015555-3533DOI Listing

Preliminary ICF core set for patients with myalgic encephalomyelitis/chronic fatigue syndrome in rehabilitation medicine.

J Rehabil Med 2020 May 28. Epub 2020 May 28.

Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Building 39, 3rd Floor, SE-182 88 Stockholm, Sweden. E-mail:

Objective: To create and evaluate a preliminary ICF Core Set for myalgic encephalomyelitis/chronic fatigue syndrome using a team-based approach.

Design: Observational study.

Subjects/patients: A total of 100 consecutive patients (mean age 45 years, standard deviation (SD) 9 years) were assessed by a rehabilitation team and included in the study. Read More

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http://dx.doi.org/10.2340/16501977-2697DOI Listing

Motor axonopathies in a mouse model of Duchenne muscular dystrophy.

Sci Rep 2020 Jun 2;10(1):8967. Epub 2020 Jun 2.

Division of Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center Box 2644, Durham, North Carolina, 27710, USA.

Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by deleterious mutations in the DMD gene which encodes the dystrophin protein. Skeletal muscle weakness and eventual muscle degradation due to loss of dystrophin are well-documented pathological hallmarks of DMD. In contrast, the neuropathology of this disease remains understudied despite the emerging evidence of neurological abnormalities induced by dystrophin loss. Read More

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http://dx.doi.org/10.1038/s41598-020-65824-1DOI Listing

Human norovirus targets enteroendocrine epithelial cells in the small intestine.

Nat Commun 2020 Jun 2;11(1):2759. Epub 2020 Jun 2.

Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Human noroviruses are a major cause of diarrheal illness, but pathogenesis is poorly understood. Here, we investigate the cellular tropism of norovirus in specimens from four immunocompromised patients. Abundant norovirus antigen and RNA are detected throughout the small intestinal tract in jejunal and ileal tissue from one pediatric intestinal transplant recipient with severe gastroenteritis. Read More

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http://dx.doi.org/10.1038/s41467-020-16491-3DOI Listing

1,25(OH)VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model.

Sci Rep 2020 Jun 2;10(1):8960. Epub 2020 Jun 2.

University of Groningen, University Medical Center Groningen, Department of Pathology & Medical Biology, Experimental Pulmonary and Inflammatory Research (EXPIRE), Groningen, The Netherlands.

Allergen specific immunotherapy (AIT) can provide long-term alleviation of symptoms for allergic disease but is hampered by suboptimal efficiency. We and others have previously shown that 1,25(OH)2-VitaminD3 (VitD3) can improve therapeutic efficacy of AIT. However, it is unknown whether VitD3 supplementation has similar effects in sublingual and subcutaneous immunotherapy. Read More

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http://dx.doi.org/10.1038/s41598-020-65946-6DOI Listing

Improving Allergy Documentation: A Retrospective Electronic Health Record System-Wide Patient Safety Initiative.

J Patient Saf 2020 Jun 1. Epub 2020 Jun 1.

From the Division of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital.

Objectives: Documentation of allergies in a coded, non-free-text format in the electronic health record (EHR) triggers clinical decision support to prevent adverse events. Health system-wide patient safety initiatives to improve EHR allergy documentation by specifically decreasing free-text allergy entries have not been reported. The goal of this initiative was to systematically reduce free-text allergen entries in the EHR allergy module. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000711DOI Listing

Environmental estrogen exposure disrupts sensory processing and nociceptive plasticity in the cephalopod, .

J Exp Biol 2020 Jun 2. Epub 2020 Jun 2.

Department of Biology, San Francisco State University, 1600 Holloway Avenue, San Francisco CA 94132, USA

Endogenous estrogens affect multiple sensory systems, including those involved in processing noxious and painful stimuli. Extensive evidence demonstrates that estrogenic environmental pollutants have profound, negative effects on growth and reproductive physiology, but there is limited information about how estrogenic pollutants might affect sensory systems known to be modulated by endogenous estrogens. Here, we show that ethinyl estradiol, the most common artificial estrogen found in coastal marine environments, disrupts normal behavioral and neural responses to tissue injury in the sepiolid, (Hawaiian bobtail squid), which inhabits shallow tropical waters close to dense human habitation. Read More

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http://dx.doi.org/10.1242/jeb.218008DOI Listing

Sex-Based Differences in Interstitial Lung Disease.

Am J Med Sci 2020 Apr 25. Epub 2020 Apr 25.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Sidney Kimmel College of Medicine; Jane & Leonard Korman Respiratory Institute, Jefferson Health, Thomas Jefferson University, 834 Walnut St, Philadelphia, PA 19107 USA. Electronic address:

Interstitial lung diseases comprise a family of progressive pulmonary disorders that are often idiopathic or associated with various systemic diseases and that is characterized by bilateral lung involvement with inflammation and tissue remodeling or fibrosis. The impact of sex, including the anatomic and physiologic traits that one is born with, on the development and progression of interstitial lung diseases is not entirely clear. Variances between men and women are driven by differences in male and female biology and sex hormones, among other differences, but their role remains uncertain. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.04.023DOI Listing

The gut microbiome's role in the development, maintenance, and outcomes of sepsis.

Crit Care 2020 Jun 1;24(1):278. Epub 2020 Jun 1.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

The gut microbiome regulates a number of homeostatic mechanisms in the healthy host including immune function and gut barrier protection. Loss of normal gut microbial structure and function has been associated with diseases as diverse as Clostridioides difficile infection, asthma, and epilepsy. Recent evidence has also demonstrated a link between the gut microbiome and sepsis. Read More

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http://dx.doi.org/10.1186/s13054-020-02989-1DOI Listing

The value of post-operative antibiotic therapy after laparoscopic appendectomy for complicated acute appendicitis: a prospective, randomized, double-blinded, placebo-controlled phase III study (ABAP study).

Trials 2020 Jun 1;21(1):451. Epub 2020 Jun 1.

Department of Digestive Surgery, Amiens University Hospital, Amiens University Medical Center, Avenue Laennec, F-80054, Amiens cedex 01, France.

Background: Approximately 30% of appendectomies are for complicated acute appendicitis (CAA). With laparoscopy, the main post-operative complication is deep abscesses (12% of cases of CAA, versus 4% for open surgery). A recent cohort study compared short and long courses of postoperative antibiotic therapy in patients with CAA. Read More

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http://dx.doi.org/10.1186/s13063-020-04411-1DOI Listing

Measuring disease activity in COPD: is clinically important deterioration the answer?

Respir Res 2020 Jun 2;21(1):134. Epub 2020 Jun 2.

Division of Pulmonary and Critical Care, University of Michigan Health System, Ann Arbor, MI, USA.

Given the heterogeneity of chronic obstructive pulmonary disease (COPD), personalized clinical management is key to optimizing patient outcomes. Important treatment goals include minimizing disease activity and preventing disease progression; however, quantification of these components remains a challenge. Growing evidence suggests that decline over time in forced expiratory volume in 1 s (FEV), traditionally the key marker of disease progression, may not be sufficient to fully determine deterioration across COPD populations. Read More

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http://dx.doi.org/10.1186/s12931-020-01387-zDOI Listing

Clinical characteristics and organ system involvement in sarcoidosis: comparison of the University of Minnesota Cohort with other cohorts.

BMC Pulm Med 2020 Jun 1;20(1):155. Epub 2020 Jun 1.

Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Univesity of Minnesota Medical School, Minneapolis, USA.

Background: Sarcoidosis is a systemic granulomatous disease of unknown etiology. Clinical cohort studies of different populations are important to understand the high variability in clinical presentation and disease course of sarcoidosis. The aim of the study is to evaluate clinical characteristics, including organ involvement, pulmonary function tests, and laboratory parameters, in a sarcoidosis cohort at the University of Minnesota. Read More

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http://dx.doi.org/10.1186/s12890-020-01191-xDOI Listing