2,213 results match your criteria Allergy and asthma proceedings[Journal]


Add-on tiotropium versus step-up inhaled corticosteroid plus long-acting beta-2-agonist in real-world patients with asthma.

Allergy Asthma Proc 2020 May 15. Epub 2020 May 15.

Background: A step-up approach (increasing inhaled corticosteroid [ICS] dose and/or add-on treatment) is recommended for asthma that is uncontrolled despite ICS plus long-acting beta-2-agonist (LABA) combination treatment. Understanding the impact of different treatment options on health outcomes can help guide treatment decision-making.

Objective: To compare the effectiveness of add-on tiotropium 1. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200036DOI Listing

Deposition characteristics of a Novel Intranasal Formulation of Azelastine Hydrochloride plus Fluticasone Propionate in an anatomic model of the human nasal cavity.

Allergy Asthma Proc 2020 May 11. Epub 2020 May 11.

Background: Intranasal antihistamines and steroids should be delivered in a volume and with a technique that allow foroptimal drug retention within the entire nasal cavity, maximize local absorption by the nasal mucosa, and, subsequently,increase the potential for the most desirable local availability and therapeutic effect.

Objective: This in vitro evaluation simulated nasal medication deposition and evaluated the extent of runoff. MP-AzeFlu,a novel intranasal formulation of azelastine hydrochloride (AZE) plus fluticasone propionate (FP), was compared with sequentialsprays of available commercial products with the individual medication components. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200028DOI Listing

Validity, reliability, and interpretability of the Brazilian urticaria control test.

Allergy Asthma Proc 2020 May;41(3):e61-e66

Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho (HUCFF-UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.

The urticaria control test (UCT) is a patient-reported outcome measure designed to determine the current level of disease control in patients with chronic urticaria (CU). Recently, a Brazilian UCT was developed, but its validity and reliability are unknown. The clinimetric properties of the Brazilian UCT short form (UCTsh) and its long form (UCTlg) were determined in 130 patients with CU. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200003DOI Listing

Shrimp and cockroach co-sensitization in Southern China: Association with moth sensitization.

Allergy Asthma Proc 2020 May;41(3):e54-e60

Moth is a common allergen in southern China. Shrimp sensitization might be related to the moth allergen. This study investigated sensitization to moth allergen in patients in southern China sensitized to shrimp and explored the effect of moth sensitization on different allergic diseases. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200013DOI Listing

For the PatientWheezing in childhood and risk of asthma.

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Allergy Asthma Proc 2020 May;41(3):224

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http://dx.doi.org/10.2500/aap.2020.41.200021DOI Listing

A 27-year-old man with recurrent sinopulmonary and cutaneous infections.

Allergy Asthma Proc 2020 May;41(3):218-223

From the Department of Pulmonary and Critical Care, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

The increasing availability of genetic testing for modern immunologists in the evaluation of immune diseases could provide a definite diagnosis in elusive cases. A 27-year-old white male patient presented to the clinic with recurrent sinopulmonary and cutaneous infections since childhood. The patient's mother had seronegative polyarthritis, and one of two sisters of the patient had chronic sinopulmonary infections. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190026DOI Listing

Association between asthma symptom scores and perceived stress and trait anxiety in adolescents with asthma.

Allergy Asthma Proc 2020 May;41(3):210-217

Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan.

Emotional disorders, including depression and anxiety, are more prevalent in individuals with asthma than in the general population and are associated with poor asthma outcomes. Identification of patients with increased levels of stress and anxiety may be helpful when treating asthma and during asthma counseling. To further characterize the relationship between asthma symptoms and perceived stress and trait anxiety in an adolescent population. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200017DOI Listing

Recurrent wheezing, allergic rhinitis, and maternal asthma as predictors of asthma in children.

Allergy Asthma Proc 2020 May;41(3):204-209

Department of Pediatrics, Federal University of Bahia School of Medicine, Salvador, Brazil.

Early prediction of asthma is crucial for asthma prevention. We estimated the odds ratio (OR) of recurrent wheezing during the first 3 years of life, atopic rhinitis, and maternal asthma for asthma in school-age children (ages ≥ 6 years). This case-control study was conducted in Salvador, Brazil. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200023DOI Listing

Effectiveness of ongoing face-to-face anti-tobacco intervention in children with asthma.

Allergy Asthma Proc 2020 May;41(3):198-203

Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland.

Interventions to help parents quit smoking may yield important benefits for children with asthma. Children's exposure to environmental tobacco smoke can be measured by reporting of an adult in the household and testing the child's biomarker, e.g. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200010DOI Listing

Electronic cigarettes: How confident and effective are allergists, pulmonologists, and primary care physicians in their practice behavior?

Allergy Asthma Proc 2020 May;41(3):192-197

There has been a striking increase in electronic cigarette (EC) use in the United States. The beliefs and practices toward ECs among physicians are unknown. The purpose of this study was to investigate EC practice patterns among allergists, pulmonologists, and primary care physicians. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200009DOI Listing

Serum immunoglobulin E reactivity to cross-reacting panallergen components in north-eastern Poland patients pollen sensitized.

Allergy Asthma Proc 2020 May;41(3):183-191

Department of Allergy and Immunology, George Washington University School of Medicine and Health Sciences, Washington, D.C.

The presence of immunoglobulin E (IgE), which cross-reacts with allergen components, such as profilins, polcalcins, and cross-reacting carbohydrate determinants (CCD), creates a problem when selecting patients for allergen immunotherapy by using conventional methods. The aim of this study was to evaluate the prevalence of sensitization to profilins, polcalcins, and CCDs in patients with seasonal pollen allergic rhinitis. The study was performed on a group of 112 patients with seasonal pollen allergic rhinitis, ages 14 to 55 years, with sensitization to at least one seasonal allergen (IgE > 0. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200002DOI Listing

Real-world cohort study of adult and pediatric patients treated for hereditary angioedema in the United States.

Allergy Asthma Proc 2020 May;41(3):172-182

Shire, a Takeda company, Division of Global Evidence and Outcomes, Lexington, Massachusetts.

There is limited real-world evidence on hereditary angioedema (HAE) patient characteristics and health-care resource utilization (HCRU); in addition, pediatric patients have been described in small cohorts. To describe patient characteristics, treatment patterns, and HCRU among adult and pediatric patients treated for HAE in a large U.S. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200011DOI Listing

Are primary care physicians following National Institute of Allergy and Infectious Disease guidelines for the prevention of peanut allergy? A survey-based study.

Allergy Asthma Proc 2020 May;41(3):167-171

Division of Allergy and Immunology, University of Michigan, Ann Arbor, Michigan, and.

The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. To assess the knowledge and practice of the NIAID guidelines among primary care physicians. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200019DOI Listing

Jellyfish anaphylaxis: A wide spectrum of sensitization routes.

Allergy Asthma Proc 2020 May;41(3):158-166

From the School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy, and the.

Recent studies demonstrated that, in the past few years, the number of jellyfish species is increasing worldwide; this increase can be explained by environmental and climatic reasons. Contacts with jellyfish can cause acute and chronic effects, including allergic reactions. Although anaphylaxis caused by jellyfish is a rare event, repetitive stings during bathing as well as marine sports and job activities represent important risk factors that can increase the probability of sensitization. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200014DOI Listing

Biologics for oral corticosteroid-dependent asthma.

Authors:
İnsu Yılmaz

Allergy Asthma Proc 2020 May;41(3):151-157

Oral corticosteroid (OCS) dependent asthma is one of the severe asthma phenotypes that requires personalized treatment. To review the role of biologic treatments in OCS-dependent asthma. A nonsystematic review was performed of emerging multiple novel biologics for potential treatment of OCS-dependent asthma. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200015DOI Listing

Real-world cohort study of adult and pediatric patients treated for hereditary angioedema in the United States.

Allergy Asthma Proc 2020 Mar 18. Epub 2020 Mar 18.

Background: There is limited real-world evidence on hereditary angioedema (HAE) patient characteristics and health-careresource utilization (HCRU); in addition, pediatric patients have been described in small cohorts.

Objective: To describe patient characteristics, treatment patterns, and HCRU among adult and pediatric patients treatedfor HAE in a large U.S. Read More

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http://dx.doi.org/10.2500/aap.2020.41.2000011DOI Listing

Incidence of depression and its influencing factors in 387 patients with asthma from Xinjiang, China.

Allergy Asthma Proc 2020 03;41(2):e45-e53

From the Traditional Uyghur Medicine Institute, Xinjiang Medical University, Urumqi City, Xinjiang, China, and.

Our study aimed to investigate the incidence of depression in 387 patients with asthma. The Zung self-rating depression scale and the Hamilton depression scale were used to evaluate the depression status in patients with asthma. Results of logistic regression analysis indicated that, severity of asthma symptoms, taking medicine, frequency of asthma onset, and lack of education were the major risk factors for depression in patients with asthma. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190034DOI Listing

Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management.

Allergy Asthma Proc 2020 03;41(2):e37-e44

Division of Allergy and Immunology, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.

Proton-pump inhibitors (PPI) are one of the most commonly prescribed drugs, and they are generally well tolerated. However, several immediate and delayed hypersensitivity reactions due to PPIs have been reported. To review the clinical characteristics and management of immune-mediated immediate and delayed hypersensitivity reactions to PPIs. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190033DOI Listing

For the Patient.

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Allergy Asthma Proc 2020 03;41(2):144

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http://dx.doi.org/10.2500/aap.2020.41.200008DOI Listing

A late preterm infant with lymphopenia.

Allergy Asthma Proc 2020 03;41(2):141-143

The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from stress, and thymectomy during cardiac surgery, is also detected. We present a newborn girl with T-cell lymphopenia of unknown etiology detected abnormal newborn screen. Read More

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http://dx.doi.org/10.2500/aap.2019.40.190015DOI Listing

Association of serum 25-OH vitamin D₃ with serum IgE and the Pediatric Asthma Severity Score in patients with pediatric asthma.

Allergy Asthma Proc 2020 03;41(2):126-133

Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran, and.

Pediatric asthma is a prevalent disease and has a significant immunologic and inflammatory nature. In recent years, the role of vitamin D₃ in immunologic processes has been studied, and many aspects of this role have been clarified in some human diseases. The aim of this study was to evaluate the relationship among the vitamin D₃ status, Pediatric Asthma Severity Score (PASS), and inflammatory indicators of pediatric asthma. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190025DOI Listing
March 2020
3.353 Impact Factor

Prevalence and management of aspirin hypersensitivity in a cardiology practice.

Allergy Asthma Proc 2020 03;41(2):120-125

From the Medstar Union Memorial Hospital, Baltimore, Maryland, and.

Data are lacking with concern to the prevalence and management of aspirin (ASA) hypersensitivity. To study the prevalence, different types of reactions, and implications for clinical management of ASA hypersensitivity in a cardiology practice. We conducted an electronic medical record review of 11,375 individuals, 5052 (44%) in the ambulatory setting, and 6323 (56%) admitted for percutaneous coronary intervention (PCI), from January 2012 to December 2013. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190032DOI Listing

Association of asthma with osteopenia, osteoporosis, osteomalacia, and fractures.

Allergy Asthma Proc 2020 03;41(2):112-119

Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC.

Previous studies that examined the relationship between asthma, osteoporosis, and pathologic fractures found conflicting results. To determine whether asthma is associated with osteopenia, osteoporosis, osteomalacia, and fractures in U.S. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190035DOI Listing

Safety of allergen immunotherapy in North America from 2008-2017: Lessons learned from the ACAAI/AAAAI National Surveillance Study of adverse reactions to allergen immunotherapy.

Allergy Asthma Proc 2020 03;41(2):108-111

In 2004, it was estimated that one fatal anaphylactic reaction (FR) occurred in every 2.4 million subcutaneous immunotherapy (SCIT) injection visits. Uncontrolled asthma was the most commonly cited factor that contributed to FRs. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200001DOI Listing

Mast cell disorders and idiopathic anaphylaxis: Evaluation and management.

Allergy Asthma Proc 2020 03;41(2):90-98

Department of Internal Medicine, Division of Allergy and Immunology, University of Tennessee Health Sciences Center, Memphis, Tennessee.

Our understanding of mast cell activation disorders continues to grow, and our management of these syndromes is improving with this increase in knowledge. Despite these advances, there remain some areas of confusion. In this article, we discussed these areas and offered thoughts about establishing the diagnosis and management. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190023DOI Listing

Proactive management of penicillin and other antibiotic allergies.

Authors:
David A Khan

Allergy Asthma Proc 2020 03;41(2):82-89

Antibiotic allergies, especially penicillin, are the most frequent drug allergy listed in the medical record. Proactive evaluations of antibiotic allergies, particularly penicillin allergies, have been recommended by various specialty societies. To review the history of the discovery of penicillin, implications of the penicillin allergy label, various delabeling strategies as well as a brief overview of the approach to cephalosporin, fluoroquinolone, and macrolide allergy. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190024DOI Listing

Benefits and risks of incorporating virtual visits into an allergy/immunology practice.

Allergy Asthma Proc 2020 03;41(2):76-81

Telemedicine (TM) involves the use of technology to overcome the patient care barriers of distance and time. Asynchronous TM can be used to monitor patients remotely and for providers and patients to communicate with each other without needing to be online at the same time. Synchronous TM can include direct-to-consumer visits in which patients use their own equipment to communicate with a provider or facilitated visits in which a patient travels to a clinic to use the clinic's equipment with a facilitator. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190022DOI Listing

A 72-year-old woman with periorbital swelling.

Allergy Asthma Proc 2020 01;41(1):e33-e36

As allergists, we are frequently consulted to evaluate patients with swelling presumed to be angioedema. Patients with presumed angioedema can have multiple possible underlying triggers. We present the case of a hospitalized 72-year-old woman with a history of hypertension and metastatic chordoma who developed marked periorbital swelling that precluded eye opening 2 days after a neurosurgical operation (chordoma resection and T10-11 hardware repair). Read More

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http://dx.doi.org/10.2500/aap.2020.41.190004DOI Listing
January 2020

sensitization in bronchial asthma: A separate phenotype.

Allergy Asthma Proc 2020 01;41(1):e26-e32

Bronchial asthma is one of the common chronic respiratory illnesses worldwide, with a global disease burden that affects approximately 300 million individuals. It affects 5-10% of the population in developed countries. India constitutes approximately one-tenth of the global disease burden, where an estimated 7 million children are affected by this illness. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190008DOI Listing
January 2020

The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study.

Allergy Asthma Proc 2020 01;41(1):e19-e25

From the Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland.

Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess the associations among cord blood concentrations of zinc (Zn); copper (Cu); selenium (Se); β-carotene; and vitamin A, E, and D, and the occurrence of atopic dermatitis, food allergy, allergic rhinitis, and asthma in early school-age children. We evaluated 211 children, 7-9 years old, from the Polish Mother and Child Cohort Study. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190020DOI Listing
January 2020

Predictors for late tolerance development in food protein-induced allergic proctocolitis.

Allergy Asthma Proc 2020 01;41(1):e11-e18

Food protein-induced allergic proctocolitis (FPIAP) is a non-immunoglobulin E (IgE) mediated food allergy that typically presents with blood-mixed mucoid stool. To identify the predictors that affect the tolerance development in infants with FPAIP and laboratory as well as clinical differences between patients with early and with late tolerance. A total of 185 infants with FPIAP were included. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190017DOI Listing
January 2020

Efficacy of Chinese Children's Asthma Action Plan in the management of children with asthma.

Allergy Asthma Proc 2020 01;41(1):e3-e10

Abundant evidence has proven the effectiveness of following an asthma action plan for children. China released its first children's asthma action plan in 2017 to improve asthma control. To assess the effectiveness of the Chinese Children's Asthma Action Plan (CCAAP) in the management of children with asthma. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190010DOI Listing
January 2020

Role of translational controlled tumor protein in omalizumab resistance.

Authors:
Sujoy Khan

Allergy Asthma Proc 2020 01;41(1):e1-e2

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http://dx.doi.org/10.2500/aap.2019.190009DOI Listing
January 2020
3.353 Impact Factor

For the Patient.

Authors:

Allergy Asthma Proc 2020 01;41(1):70

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http://dx.doi.org/10.2500/aap.2020.41.190027DOI Listing
January 2020

A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia.

Allergy Asthma Proc 2020 01;41(1):66-69

From the Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.

Mycobacterium avium complex (MAC) infections, generally viewed as opportunistic infections, often trigger an evaluation for an underlying immunodeficiency disorder. However, MAC infections can occur in patients who presumably are immunocompetent, particularly in those with an underlying structural lung disease. T-cell immunity plays a critical role in controlling MAC infection. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190003DOI Listing
January 2020

Correlation of serum interleukin-31 with pruritus and blood eosinophil markers in children with atopic dermatitis.

Allergy Asthma Proc 2020 01;41(1):59-65

From the Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.

Atopic dermatitis (AD) is chronic pruritic inflammatory skin disease in children. Interleukin (IL) 31 is a recently discovered cytokine associated with chronic skin inflammation and pruritus. The aims of this study were to determine whether serum IL-31 levels are increased in children with AD and to examine the relationship between IL-31 and other clinical biomarkers in AD. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190016DOI Listing
January 2020

Efficacy of epinephrine and diphenhydramine rinses in decreasing local reactions to subcutaneous aeroallergen immunotherapy.

Allergy Asthma Proc 2020 01;41(1):52-58

From the Rochester Regional Health, Rochester, New York.

Although local reactions (LR) to subcutaneous immunotherapy (SCIT) occur in 26-86% of patients, there are no well-studied strategies to manage LRs. To complete a prospective, randomized, single-blind, controlled trial that compared pre-rinsing SCIT syringes with diphenhydramine, epinephrine, or placebo in patients who were receiving aeroallergen SCIT and experiencing LRs despite pretreatment with an antihistamine. Patients ages ≥5 years who were receiving aeroallergen SCIT per a conventional dosing schedule and who were experiencing LRs despite premedicating with an oral antihistamine were randomized to diphenhydramine, epinephrine, or placebo rinse, and were followed up for three subsequent visits. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190018DOI Listing
January 2020

Outdated allergens are similar to unexpired extracts for the detection of allergen sensitization.

Allergy Asthma Proc 2020 01;41(1):45-51

From the Allergy and Clinical Immunology Unit, E. Wolfson Medical Center, Holon, Israel, and.

Allergen extracts have relatively short shelf lives, which limits their use and increase financial loss and waste on unused extracts. It is thus important to determine if efficacy persists beyond the expiration date. To determine the efficacy and bioavailability of outdated allergen extracts for diagnosis of allergic sensitizations. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190019DOI Listing
January 2020

Allergy immunotherapy for inhalant allergens: Strategies to minimize adverse reactions.

Authors:
Harold S Nelson

Allergy Asthma Proc 2020 01;41(1):38-44

Allergy immunotherapy (AIT), both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), is an effective and safe treatment for allergic rhinitis and allergic asthma due to inhalant allergens. However, there are many variables in how it is administered. To review the evidence that suggests the optimal practice(s) to minimize adverse reactions to AIT. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190014DOI Listing
January 2020

Allergy immunotherapy for inhalant allergens: Strategies to improve efficacy.

Authors:
Harold S Nelson

Allergy Asthma Proc 2020 01;41(1):26-37

Allergy immunotherapy (AIT), both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), is an effective and safe treatment for allergic rhinitis and allergic asthma due to inhalant allergens. However, there are many variables in how it is administered. To review the evidence that suggests the optimum practices to enhance the efficacy of AIT. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190013DOI Listing
January 2020

Personalized therapy for common variable immunodeficiency.

Allergy Asthma Proc 2020 01;41(1):19-25

Common variable immunodeficiency (CVID) represents a clinical descriptive diagnosis that was defined in the 1970s. Despite the vast increase in knowledge with regard to immune function and genetics, the pathophysiology of this disorder remains poorly understood in the majority of patients (75%); however, recent advances have led to a much clearer understanding of this heterogeneous group of disorders in the remaining 25%. These advances, along with developments in immune modulatory and reconstitution therapies, now permit sophisticated and specific targeting of therapies for individual patients. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190012DOI Listing
January 2020

Long-term safety outcomes of prekallikrein (Fletcher factor) deficiency: A systematic literature review of case reports.

Allergy Asthma Proc 2020 01;41(1):10-18

Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio.

Hereditary prekallikrein (Fletcher factor) deficiency is a rare condition characterized by a prolonged activated partial thromboplastin time. Inhibitors of plasma kallikrein have recently been approved for prophylaxis of hereditary angioedema and are under investigation for use in other indications. We attempted to conservatively assess the impact of long-term inhibition of this pathway by reviewing reported comorbidities in patients with hereditary prekallikrein deficiency. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190005DOI Listing
January 2020

Advances in the management of peanut allergy (oral immunotherapy and epicutaneous immunotherapy).

Authors:
Julie Wang

Allergy Asthma Proc 2020 01;41(1):5-9

Peanut allergy affects up to 2% of the general population and carries not only the risk of potentially life-threatening allergic reactions but also negatively impacts day to day life for patients and their families. Advances in knowledge in immunotherapy is providing families with options for proactive treatment. To examine the available data for oral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) for peanut allergy. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190011DOI Listing
January 2020

Manufacturing of plasma-derived C1-inhibitor concentrate for treatment of patients with hereditary angioedema.

Allergy Asthma Proc 2020 03 3;41(2):99-107. Epub 2019 Dec 3.

CSL Behring, Bern, Switzerland.

Replacement therapy with plasma-derived C1-inhibitor (C1-INH) has been used for decades to treat patients with hereditary angioedema (HAE) with C1-INH deficiency. This article reviewed the rationale for using C1-INH replacement therapy in patients with HAE and the process of manufacturing plasma-derived C1-INH. The manufacture of C1-INH is an involved and carefully monitored process that includes screening and selection of prospective donors, the collection of source plasma, and purification with dedicated pathogen reduction steps. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190021DOI Listing
March 2020
5 Reads
3.353 Impact Factor

Unproved and controversial methods and theories in allergy/immunology.

Allergy Asthma Proc 2019 11;40(6):490-493

Unproved methods and controversial theories in the diagnosis and management of allergy/immunology are those that lack scientific credibility. Some definitions are provided for perspective, as in chronic medical conditions, frequently nonscientifically based treatments are developed that can have a profound psychological effect on the patients in the absence of objective physical benefit. Standard practice uses methods of diagnosis and treatment used by reputable physicians in a particular subspecialty or primary care practice, with the understanding that diagnosis and treatment options are consistent with established mechanisms of conditions or diseases. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4278DOI Listing
November 2019
4 Reads

Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

Allergy Asthma Proc 2019 11;40(6):485-489

Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (dupilumab) treatments for these allergic diseases. In addition, we discussed emerging immunobiologic therapies, such as tezepelumab. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4277DOI Listing
November 2019
1 Read