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    1929 results match your criteria Allergy and Asthma Proceedings[Journal]

    1 OF 39

    Recombinant human C1 esterase inhibitor for acute hereditary angioedema attacks with upper airway involvement.
    Allergy Asthma Proc 2017 Sep 13. Epub 2017 Sep 13.
    Background: Recombinant human C1 esterase inhibitor (rhC1-INH) is approved for treatment of hereditary angioedema (HAE)in adolescents and adults. HAE attacks that involve the upper airway can be life threatening, and data on the administration of rhC1-INH for these types of attacks are currently limited.

    Objective: To evaluate the efficacy and safety of rhC1-INH for treatment of acute HAE attacks with upper airway involvement. Read More

    Evaluation of beclomethasone dipropionate (80 and 160 micrograms/day) delivered via a breath-actuated inhaler for persistent asthma.
    • Authors:
    Allergy Asthma Proc 2017 Sep 8. Epub 2017 Sep 8.
    Background: Breath-actuated inhalers (BAI) may simplify the delivery of inhaled medications compared with other devices.

    Objective: To evaluate the efficacy and safety of beclomethasone dipropionate BAI versus matching placebo in adolescent and adult patients with persistent asthma.

    Methods: This phase III, 12-week, double-blind study enrolled patients with asthma aged greater than or equal to 12 years who were previously treated with a stable dose of inhaled corticosteroid or noncorticosteroid therapy. Read More

    Efficacy of recombinant human C1 esterase inhibitor for the treatment of severe hereditary angioedema attacks.
    Allergy Asthma Proc 2017 Sep 5. Epub 2017 Sep 5.
    Background: Severe attacks of hereditary angioedema (HAE) are debilitating and potentially life threatening, and can increase anxiety and the use of medical resources.

    Objective: This post hoc assessment evaluated recombinant human C1 esterase inhibitor (rhC1-INH) used to treat acute severe HAE attacks.

    Methods: In a double-blind, randomized-controlled trial (RCT), patients with an HAE attack (baseline visual analog scalescore of greater than or equal to 50 mm, with severe attacks defined as greater than or equal to 75 mm) were randomly assigned to receive rhC1-INH (50 IU/kg for patients who weighed <84 kg; 4200 IU for patients who weighed more than or equal to 84 kg) or placebo. Read More

    Health-related quality of life in relation to disease activity in adults with hereditary angioedema in Sweden.
    Allergy Asthma Proc 2017 Aug 30. Epub 2017 Aug 30.
    Background: Health-related quality of life (HR-QoL) is impaired in patients with hereditary angioedema (HAE) but has notyet been satisfactorily described.

    Objective: To study HR-QoL in patients with HAE by combining different HR-QoL instruments with disease activity assessment.

    Methods: All adults in the Swedish HAE registry were invited to take part in this questionnaire study, which used the generic HR-QoL instruments, EuroQol 5 Dimensions 5 Level (EQ-5D-5L) and the RAND Corporation Short Form 36 (RAND-36), the disease-specific Angioedema Quality of Life instrument (AE-QoL), the recently introduced Angioedema Activity Score (AAS) form, and questionnaires on sick leave and prophylactic medication. Read More

    Skin rash in a 2-week-old infant.
    Allergy Asthma Proc 2017 09;38(5):390-393
    We presented a case of a male infant with annular patchy rash on his torso since 2 weeks of age. This was initially diagnosed as tinea corporis but did not respond to oral antifungal treatment. Because of the appearance of the rash and a history of a certain disease in a maternal aunt, we suspected the most probable cause of the rash and the diagnosis was confirmed by laboratory testing. Read More

    The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study.
    Allergy Asthma Proc 2017 Sep;38(5):383-389
    Background: The relationship between autoimmune connective tissue disease (ACTD) and atopy is controversial.

    Objectives: To investigate the risks of ACTDs in patients with atopic triad diseases, including atopic dermatitis, allergic rhinitis, and asthma, by using a nationwide data base.

    Methods: A cohort of 155,311 patients newly diagnosed with atopic dermatitis, allergic rhinitis, or asthma in 2002-2011 was obtained from the Taiwan National Health Insurance Research Database. Read More

    Frequency of selective immediate responders to aminopenicillins and cephalosporins in Turkish children.
    Allergy Asthma Proc 2017 Sep;38(5):376-382
    Background: Beta-lactam antibiotics (BLA) are the most commonly prescribed antibiotics and are responsible for the majority of immediate hypersensitivity reactions to drugs in children. Cross-reactivity is important in hypersensitivity to BLAs because these drugs all share a common beta-lactam structure and some share similar side chains.

    Objective: The aim of this study was to evaluate the clinical characteristics of patients who are diagnosed with immediate-type BLA hypersensitivity and frequency of patients with side chain hypersensitivity, "selective responders. Read More

    Association of aeroallergen sensitization and atopic disease in the Sonoran Desert.
    Allergy Asthma Proc 2017 Sep;38(5):370-375
    Background: Numerous aeroallergens have been associated with the development of asthma, including Alternaria, house-dust mite, and pet dander. Tucson, Arizona, is located in the Sonoran Desert, which has the highest diversity of vegetation of any desert in the world. Given the unique pollen profile in this region, we sought to identify the most common aeroallergens associated with rhinitis and asthma diagnosis in the local adult population. Read More

    Pneumococcal 13-valent conjugate vaccine administration after inferior response to pneumococcal vaccine.
    Allergy Asthma Proc 2017 Sep;38(5):365-369
    Background: The pneumococcal vaccine, a nonconjugated vaccine, may be used to evaluate the integrity of the humoral immune system. Those patients with an inferior response to a nonconjugated vaccine may be vaccinated with a conjugated vaccine, which elicits both a B- and T-cell response.

    Objective: We evaluated the immunogenicity of a conjugated vaccine in patients with inferior responses to a nonconjugated vaccine. Read More

    Der p 1 and Der p 2 specific immunoglobulin E measurement for diagnosis of Dermatophagoides pteronyssinus allergy: A systematic review and meta-analysis.
    Allergy Asthma Proc 2017 Sep;38(5):333-342
    Background: A clinical history of allergic symptoms and a skin-prick test with house-dust mite crude extracts are standard diagnostic procedures for Dermatophagoides pteronyssinus allergy. Specific immunoglobulin E (IgE) responses to Der p 1 and Der p 2 allergens have been used for the diagnosis of D. pteronyssinus allergy; however, evaluation of the diagnostic performance of Der p 1 and Der p 2 specific IgE (sIgE) produced inconsistent findings. Read More

    Pre- and postoperative blood neutrophil-to-lymphocyte and eosinophil-to-lymphocyte ratios in patients with sinonasal polyps: A preliminary investigation.
    Allergy Asthma Proc 2017 Sep;38(5):64-69
    Background: Identifying specific endotypes within the broad picture of chronic rhinosinusitis with nasal polyps (CRSwNP), by using biomarkers for instance, remains a challenge. The prognostic role of the neutrophil-to-lymphocyte ratio (NLR) and the eosinophil-to-lymphocyte ratio (ELR) as potential markers of inflammation has already been discussed.

    Objective: The aim of the present study was to compare NLR and ELR before and after endoscopic sinus surgery (ESS) and nasal mometasone furoate for CRSwNP by stratifying patients by their clinical and histologic features. Read More

    Characteristics of drug-induced anaphylaxis in children and adolescents.
    Allergy Asthma Proc 2017 Sep;38(5):56-63
    Background: Although data on anaphylaxis in the general population exist for different allergens, there is still lack of detailed etiologic data on drug-induced anaphylaxis (DIA), particularly in children.

    Objective: To define the etiology of DIA, to determine the accuracy of drug-related anaphylaxis histories, along with the severity and culprit drug associations among individuals <18 years old.

    Methods: Patients with a history of drug hypersensitivity reaction (DHR) referred to our center between January 2012 and February 2016 were included. Read More

    Indicators of poorly controlled asthma and health-related quality of life among school-age children in the United States.
    Allergy Asthma Proc 2017 Aug 11. Epub 2017 Aug 11.
    Background: Poorly controlled asthma has far-reaching effects on school-age children and their parents, but little is knownabout the national impact on health-related quality of life (HRQoL).

    Objective: To examine HRQoL associated with asthma and indicators of poorly controlled asthma in the United States.

    Methods: This was a cross-sectional analysis of HRQoL among school-age children (age range, 6-17 years) with asthma in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). Read More

    Efficacy and safety of beclomethasone dipropionate breath-actuated or metered-dose inhaler in pediatric patients with asthma.
    Allergy Asthma Proc 2017 Sep 14;38(5):354-364. Epub 2017 Jul 14.
    Background: Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify the delivery of inhaled medication.

    Objective: To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years with persistent asthma.

    Methods: In this double-blind, double-dummy, phase III study, 628 children with persistent asthma were randomly assigned (1:1:1:1:1) to twice-daily beclomethasone dipropionate (BAI 80 μg/day, BAI 160 μg/day, MDI 80 μg/day, or MDI 160 μg/day) or to placebo. Read More

    A 28-year-old woman with fever, rash, and pancytopenia.
    Allergy Asthma Proc 2017 Jul;38(4):322-327
    A 28-year-old Hispanic woman was admitted to the hospital with fever, sore throat, arthralgia, and a generalized rash of 2 weeks' duration. Her medical history was significant for various food and medication allergies. Multiple antibiotics were given for suspected infection, and she subsequently developed a new skin rash, acute liver injury, eosinophilia, and pancytopenia. Read More

    Pearls and pitfalls: Autoimmune lymphoproliferative syndrome and autoimmune lymphoproliferative syndrome-like disease.
    Allergy Asthma Proc 2017 Jul;38(4):317-321
    A case of autoimmune lymphoproliferative syndrome (ALPS) was presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Clinical pearls and pitfalls are emphasized for the use of the practicing allergist and the fellow in-training. The diagnosis of ALPS was guided by published criteria. Read More

    A 10-year experience of a novel and safe modified environmental rush immunotherapy protocol.
    Allergy Asthma Proc 2017 Jul;38(4):309-316
    Background: Allergen immunotherapy (AIT) is an effective treatment option for allergic rhinitis. Although conventional AIT takes 6 months to reach maintenance dosing, rush AIT accelerates the build-up period and reaches the maintenance dose months earlier. However, accelerated schedules of AIT carry an increased risk of systemic reactions (SR). Read More

    Association of maternal depression and allergic diseases in Korean children.
    Allergy Asthma Proc 2017 Jul;38(4):300-308
    Purpose: An association between childhood allergic disease and parental psychological disorders has been reported. However, little is known about the relationship between childhood allergic disease and maternal depression. This study was performed to determine if there is an association between childhood allergic disease and maternal depression. Read More

    Seasonal variation and monthly patterns of skin symptoms in Korean children with atopic eczema/dermatitis syndrome.
    Allergy Asthma Proc 2017 Jul;38(4):294-299
    Background: There have been controversies about the seasonality in aggravation of atopic eczema/dermatitis syndrome (AEDS) symptoms, although understanding the seasonal patterns of AEDS symptoms is an important step in preventing exacerbation through proactive management.

    Objective: The aim of this study was to evaluate whether there are seasonal variations or monthly patterns of symptoms in children with AEDS.

    Methods: A total of 590 children with AEDS (median age, 21 months) were enrolled and were followed up for at least 1 year between August 2012 and March 2015. Read More

    Prevalence and triggers of anaphylactic events in schools.
    Allergy Asthma Proc 2017 Jul;38(4):286-293
    Background: Prevention and management of anaphylaxis in schools is an area of active interest as allergy and asthma rates in children continue to increase. A greater understanding of the prevalence and characteristics of anaphylaxis can help guide preventive and management strategies both within and outside of the school setting, with the goal of reducing morbidity and mortality.

    Objective: This study was performed to elucidate the epidemiology of and management strategies for anaphylaxis in the school setting. Read More

    Asthma in older people hospitalized with influenza in Spain: A case-control study.
    Allergy Asthma Proc 2017 Jul;38(4):277-285
    Background: Influenza infection is an exacerbating factor for asthma, and its prevention is critical in older patients with asthma.

    Objective: This study investigated the association between asthma and influenza-related hospitalization, in Spain, of patients ages ≥ 65 years and their clinical evolution.

    Methods: A multicenter case-control study was carried out in 20 Spanish hospitals during the 2013-2014 and 2014-2015 influenza seasons. Read More

    Atopic dermatitis treatment: Current state of the art and emerging therapies.
    Allergy Asthma Proc 2017 Jul;38(4):243-249
    Background: Atopic dermatitis (AD) can be debilitating and often requires the use of combination topical and systemic therapy to achieve adequate disease control.

    Methods: A non-systematic review was performed of current state of the art and emerging therapies for AD.

    Results: There are a number of topical agents approved by the U. Read More


    Fluticasone propionate and fluticasone propionate/salmeterol multidose dry powder inhalers compared with placebo for persistent asthma.
    Allergy Asthma Proc 2017 Sep 21;38(5):343-353. Epub 2017 Jun 21.
    Background: A novel, inhalation-driven, multidose dry powder inhaler (MDPI) has been developed, which allows for lower doses of fluticasone propionate (Fp) and Fp/salmeterol (FS) for the treatment of patients with asthma.

    Objective: This phase III, multicenter, double-blind, parallel-group study (NCT02141854) evaluated the efficacy and safety of Fp MDPI and FS MDPI versus placebo MDPI.

    Methods: Patients aged ≥12 years with persistent asthma who previously took an inhaled corticosteroid with or without a long-acting beta-agonist entered a 14- to 21-day run-in period, during which they received single-blind, low-dose Fp MDPI 50 μg (1 inhalation twice daily [b. Read More

    Efficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: A systematic literature review.
    Allergy Asthma Proc 2017 Jul 19;38(4):250-263. Epub 2017 Jun 19.
    Background: There are limited pediatric data about the use of omalizumab, especially the effectiveness and safety of omalizumab in the real-world management of allergic asthma.

    Objective: The objective of this study was to summarize the safety and efficacy of omalizumab in both randomized clinical trials (RCT) used for U.S. Read More

    A 6-month safety and efficacy study of fluticasone propionate and fluticasone propionate/salmeterol multidose dry powder inhalers in persistent asthma.
    Allergy Asthma Proc 2017 Jul 24;38(4):264-276. Epub 2017 May 24.
    Background: A novel multidose dry powder inhaler (MDPI) that is breath actuated, easy, and intuitive to use has been developed for administering fluticasone propionate (Fp) and Fp/salmeterol (FS).

    Objective: To assess the safety and efficacy of Fp MDPI versus Fp hydrofluoroalkane (HFA) and FS MDPI versus FS dry-powder inhaler (DPI).

    Methods: This phase III, 26-week, open-label, active drug-controlled study enrolled subjects ≥12 years old with persistent asthma. Read More

    A 30-year-old woman with chronic hives, intermittent fevers, and joint pain.
    Allergy Asthma Proc 2017 May;38(3):231-235
    Chronic urticaria with concomitant systemic symptoms may be seen in several rheumatologic and autoinflammatory conditions. Although most of these conditions tend to improve with corticosteroids, symptoms often recur with dose tapering. The appearance of the rash in addition to the symptom pattern and laboratory data must be considered to differentiate potential causes. Read More

    Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis.
    Allergy Asthma Proc 2017 May;38(3):222-230
    Background: Pharmacologic treatment is a mainstay of allergy therapy and many caregivers use over-the-counter antihistamines for the treatment of seasonal allergic rhinitis (SAR) symptoms in children.

    Objective: To assess the efficacy and safety of cetirizine 10 mg syrup versus loratadine 10 mg syrup versus placebo syrup in a randomized double-blind study of children, ages 6-11 years, with SAR.

    Methods: This randomized, double-blind, parallel-group, placebo-controlled study was conducted at 71 U. Read More

    Safety of a C1-inhibitor concentrate in pregnant women with hereditary angioedema.
    Allergy Asthma Proc 2017 May;38(3):216-221
    Background: Increased estrogen levels during pregnancy can exacerbate hereditary angioedema (HAE), yet disease and treatment ramifications remain poorly studied in pregnant women.

    Objective: Data from the international Berinert Patient Registry were used to evaluate outcomes of pregnancies exposed to plasma-derived, pasteurized, nanofiltered C1-inhibitor concentrate (pnfC1-INH) during routine HAE management.

    Methods: This observational registry, conducted between 2010 and 2014 at 30 U. Read More

    In vitro impact of anti-immunoglobulin E monoclonal antibodies, including omalizumab on whole blood basophil histamine release: Assessment of direct induction of basophil histamine release and evaluation of modulation of allergen-induced basophil histamine release.
    Allergy Asthma Proc 2017 May;38(3):204-215
    Aim: The aim of this study was to evaluate the potential of anti-immunoglobulin E (IgE) and/or anti-IgE-IgE immune complexes to release histamine from peripheral blood basophils. In addition, a potential modulating effect of anti-IgE-IgE complexes on allergen-induced peripheral blood basophil histamine release was evaluated.

    Methods: Whole blood basophil histamine release (WBB-HR) tests done by using glass-fiber-based microtiter plates were performed in 62 patients with allergic rhinitis and/or asthma sensitized to perennial allergens. Read More

    High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.
    Allergy Asthma Proc 2017 May;38(3):197-203
    Background: High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma.

    Objective: The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma.

    Methods: Thirty children with asthma and 44 healthy children were enrolled. Read More

    Asthma pathogenesis, diagnosis, and management in the elderly.
    Allergy Asthma Proc 2017 May;38(3):184-191
    Background: Due to the aging population, there is an increase in the number of elderly patients with asthma. Although signs and symptoms are similar to those in younger patients, diagnosis can be challenging due to presence of coexisting conditions in this population.

    Objectives: The purpose of this review was to highlight the challenges with regards to diagnosis, management, the high rates of medical costs and mortality in elderly asthmatics. Read More

    Hypersensitivity to biomedical implants: Prevention and diagnosis.
    Allergy Asthma Proc 2017 May;38(3):177-183
    Background: There has been growing interest in the potential for adverse immunologic reactions to metals in biomedical devices and increasing referrals for the evaluation and management of metal hypersensitivity reactions reported in orthopedic, cardiac, gynecologic, and dental implant devices. However, there are few studies that give evidence-based recommendations on how to evaluate this issue in our practices.

    Methods: We reviewed reasonable evidence and expert opinion on biomedical device hypersensitivity and published guidelines on pre- and postimplantation evaluation of delayed hypersensitivity reactions in patients suspected of possible metal hypersensitivity to biomedical devices. Read More

    Asthma control in Saudi Arabia: Gender implications.
    Allergy Asthma Proc 2017 May;38(3):47-53
    Background: Gender-related factors in asthma control should be considered in clinical consultations to substantially improve asthma control in women. Meanwhile, a limited number of studies have been reported on gender differences in factors related to asthma control, especially in Saudi Arabia.

    Objective: To study the potential gender differences in factors associated with asthma control among adult patients with physician-diagnosed asthma. Read More

    Association between depression and asthma in Korean adults.
    Allergy Asthma Proc 2017 May;38(3):37-46
    Purpose: Asthma is a one of the most common allergic diseases, and depression is an important comorbidity with asthma. However, little is known about the prevalence of depression in Korean adults with asthma. This study was performed to find the association between asthma and depression in Korean adults and to investigate the demographic and socioeconomic characteristics in Korean adults with asthma and with depression. Read More

    25-Hydroxyvitamin D, biomarkers of eosinophilic inflammation, and airway remodeling in children with newly diagnosed untreated asthma.
    Allergy Asthma Proc 2017 May;38(3):29-36
    Background: Low 25-hydroxyvitamin D (25[OH]D) and asthma development may be related to airway remodeling and eosinophilia. Periostin is proposed as a key molecule that links remodeling and eosinophilic inflammation.

    Objective: We evaluated the association of 25(OH)D concentration with periostin, peripheral blood eosinophil counts, and immunoglobulin E (IgE) in children with newly diagnosed asthma. Read More

    Vitamin D and food allergies in children: A systematic review and meta-analysis.
    Allergy Asthma Proc 2017 May;38(3):21-28
    Background: Vitamin D insufficiency has been associated with immune dysfunction and linked to the epidemic of atopic diseases in the Western hemisphere, yet there are studies with conflicting results, and the risk has not been quantified uniformly across studies.

    Objective: To perform a systematic review and meta-analysis to evaluate and quantify if vitamin D deficiency is associated with the presence and persistence of food allergy.

    Methods: A systematic review was undertaken to assess for the association between food allergy and vitamin D status in children. Read More

    A randomized study of BI 671800, a CRTH2 antagonist, as add-on therapy in poorly controlled asthma.
    Allergy Asthma Proc 2017 Mar;38(2):157-164
    Background: Asthma is characterized by a complex interaction of inflammatory mediators. The prostaglandin D2 receptor, chemoattractant receptor-homologous molecule on Th2 cells (CRTH2), plays a pivotal role in the pathogenesis of allergic airway inflammation.

    Objective: To ealuate the efficacy, safety, and pharmacokinetics of BI 671800, a CRTH2 antagonist, when added to inhaled corticosteroid therapy in adult patients with symptomatic asthma. Read More

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