187 results match your criteria Allergy Asthma And Clinical Immunology[Journal]


Post-viral atopic airway disease: pathogenesis and potential avenues for intervention.

Expert Rev Clin Immunol 2018 Oct 27:1-10. Epub 2018 Oct 27.

a Division of Allergy and Immunology , Nationwide Children's Hospital - The Ohio State University College of Medicine , Columbus , OH , USA.

Introduction: In early childhood, wheezing due to lower respiratory tract illness is often associated with infection by commonly known respiratory viruses such as respiratory syncytial virus (RSV) and human rhinovirus (RV). How respiratory viral infections lead to wheeze and/or asthma is an area of active research. Areas covered: This review provides an updated summary of the published information on the development of post-viral induced atopy and asthma and the mechanisms involved. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1541737DOI Listing
October 2018
19 Reads

Chronic rhinosinusitis with nasal polyps: insights into mechanisms of disease from emerging biological therapies.

Expert Rev Clin Immunol 2018 Oct 27:1-13. Epub 2018 Oct 27.

a Rhinology Section, Specialist Allergy and Clinical Immunology , Royal National Throat Nose and Ear Hospital London and University College London Hospital NHS Foundation Trust, University College London , London , UK.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease of the upper airway, with long-term morbidity. With detailed mechanistic studies currently lacking, understanding of the immunopathogenesis is still limited. However, outcomes from CRSwNP clinical studies using biologics that block key mediators or cells may provide some insights into how immune signaling pathways potentially integrate and modulate each other and contribute to disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1541738DOI Listing
October 2018
18 Reads

Stress, mindfulness, and the allergic patient.

Expert Rev Clin Immunol 2018 12 20;14(12):1065-1079. Epub 2018 Oct 20.

b Department of Psychology , The University of Toledo , Toledo , OH , USA.

Introduction: The global incidence and prevalence of allergic diseases are increasing as is the intensity and duration of excessive psychological stress due to multiple factors associated with living in today's world such as personal, social and political unrest, increased fear and anxiety, and/or depression often leading to hopelessness. Both allergy and chronic psychological stress are characterized by immune imbalances that have similar characteristics. Thus, it is reasonable to posit that the two are interactive and stress may induce as well as complicate at least some allergic diseases. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
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http://dx.doi.org/10.1080/1744666X.2018.1536547DOI Listing
December 2018
10 Reads

Acid suppressant medications and the risk of allergic diseases.

Expert Rev Clin Immunol 2018 09 24;14(9):771-780. Epub 2018 Aug 24.

a Division of Rheumatology, Allergy and Immunology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.

Introduction: Acid suppressant medications (ASMs), such as proton pump inhibitors and histamine-2 receptor antagonists, are used often and throughout the lifespan. These medications have been linked to the development of a variety of allergic diseases. Areas covered: This review discusses prior studies investigating the association between acid ASM exposure and the development of allergic diseases. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1512405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332498PMC
September 2018
10 Reads
3.342 Impact Factor

Immunological mechanisms underlying chronic rhinosinusitis with nasal polyps.

Expert Rev Clin Immunol 2018 09 22;14(9):731-737. Epub 2018 Aug 22.

a Personalized Medicine , Asthma and Allergy - Humanitas Research Hospital , Milan , Italy.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and quality-of-life impacting disorder, with an underlying immunological mechanism similar to other conditions such as eosinophilic asthma or atopic eczema. Areas covered: This review article summarizes the most recent evidence on the main immunological mechanisms involved in the pathogenesis and the perpetuation of CRSwNP, with a particular focus on the key role of epithelium-derived inflammation as a consequence of the interaction with the airborne environment. Expert commentary: The increase in knowledge of the immunology of CRSwNP leads to the development of therapeutical strategies based upon the use of biologic agents that, according to a personalized and precision medicine approach, will provide each single patient with the most suitable immunological treatment. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1512407DOI Listing
September 2018
3 Reads

Biomarkers of immunotherapy response in patients with allergic rhinitis.

Expert Rev Clin Immunol 2018 08 31;14(8):657-663. Epub 2018 Jul 31.

b Pediatric Allergy , IRCCS Istituto Giannina Gaslini , Genoa , Italy.

Introduction: Allergen immunotherapy represents the only disease-modifying therapy available for immunoglobulin E-mediated diseases such as allergic rhinitis and asthma. Allergen immunotherapy induces allergen tolerance by interfering with the immune-pathogenic mechanisms of the allergic response and is potentially able to provide long-term relief of symptoms of allergic rhinitis and asthma and alter the natural course of allergic diseases. Areas covered: Since allergen immunotherapy (AIT) is actually considered an individualized treatment on patient's clinical and immunological profile, the identification of specific biomarkers, which may guide diagnosis, management, and predict response to AIT treatment in allergic rhinitis (AR) patients, is essential and is currently an active field of research. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1504679DOI Listing
August 2018
5 Reads

The nasal microbiome: opening new clinical research avenues for allergic disease.

Expert Rev Clin Immunol 2018 08 25;14(8):645-647. Epub 2018 Jul 25.

a Allergy and Immunology Division, Department of Internal Medicine , Rush University Medical Center , Chicago , IL , USA.

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http://dx.doi.org/10.1080/1744666X.2018.1500177DOI Listing
August 2018
1 Read

New biologics for allergic diseases.

Expert Rev Clin Immunol 2018 04 10;14(4):285-296. Epub 2018 Apr 10.

b The Cohen Family Asthma Institute, Division of Pulmonary, Critical Care, and Sleep Medicine , National Jewish Health , Denver , CO , USA.

Introduction: Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation. Read More

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http://dx.doi.org/10.1080/1744666X.2018.1459188DOI Listing
April 2018
10 Reads

Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma?

Authors:
Paul E Pfeffer

Expert Rev Clin Immunol 2018 04 20;14(4):241-243. Epub 2018 Feb 20.

a William Harvey Research Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London , UK.

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http://dx.doi.org/10.1080/1744666X.2018.1440207DOI Listing
April 2018
2 Reads

Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma.

Clin Immunol 2018 03 28;188:7-11. Epub 2017 Nov 28.

Université Paris Descartes, Paris, France; Laboratory of Immunoregulation and Immunopathology, INEM (Institut Necker-Enfants Malades), CNRS UMR8253, and INSERM UMR1151, Paris, France. Electronic address:

IL-17 and mucosal-associated invariant T (MAIT) cells have been involved in asthma pathogenesis. However, IL-17-producing MAIT cells (MAIT-17) were not evidenced. We aimed to determine whether circulating MAIT-17 were detectable in children with asthma, and whether they correlated with asthma symptoms or lung function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616173043
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http://dx.doi.org/10.1016/j.clim.2017.11.009DOI Listing
March 2018
24 Reads

Grass pollen sublingual immunotherapy tablets provide long-term relief of grass pollen-associated allergic rhinitis and reduce the risk of asthma: findings from a retrospective, real-world database subanalysis.

Expert Rev Clin Immunol 2017 12 6;13(12):1199-1206. Epub 2017 Nov 6.

d Institute of Epidemiology , Helmholtz Zentrum Munich, German Research Centre for Environmental Health GmbH , Neuherberg , Germany.

Background: We assessed real-world, long-term effectiveness of two marketed sublingual immunotherapy (SLIT) tablets for allergic rhinitis (AR), and their impact on allergic asthma (AA) onset/progression.

Methods: Retrospective, longitudinal German prescription database subanalysis of AR patients receiving 5- or 1-grass pollen SLIT tablets (n = 1,466/1,385), versus patients not using allergy immunotherapy (AIT) (n = 71,275). Primary endpoint: change over time in AR symptomatic medication prescriptions after treatment cessation; secondary endpoints: new asthma onset, and change over time in asthma medication prescriptions during treatment/follow-up periods. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1398082DOI Listing
December 2017
14 Reads

Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice.

Clin Immunol 2018 02 14;187:58-67. Epub 2017 Oct 14.

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Dendritic cells (DCs) are professional antigen-presenting cells, and Notch ligand Delta-like-1 (DLL1) on DCs was implicated in type 1T helper (Th1) differentiation. In this study, we produced genetically engineered bone marrow-derived DCs that expressed DLL1 (DLL1-DCs) by adenoviral transduction. DLL1-DCs exerted a fully mature phenotype, and had positive effects on expression levels of interleukin (IL)-12 and costimulatory molecules. Read More

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http://dx.doi.org/10.1016/j.clim.2017.10.005DOI Listing
February 2018
2 Reads

Practical approach to the treatment of NSAID hypersensitivity.

Expert Rev Clin Immunol 2017 11 19;13(11):1017-1027. Epub 2017 Sep 19.

a Allergy Service , Hospital Infanta Leonor , Madrid , Spain.

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently involved in drug hypersensitivity reactions (DHR). NSAIDs are prescribed for different processes and some NSAIDs can be obtained over the counter. Areas covered: We analyse the practical approaches for managing and treating NSAID-DHR considering the five major groups of entities recognised, divided into two categories: those responding to strong COX-1 inhibitors and possibly weak COX-1 or selective COX-2 inhibitors named cross-intolerant (CI), and those induced by a single drug or drug group with good tolerance to strong COX-1 inhibitors, known as allergic reactions (SR). Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2017.1
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http://dx.doi.org/10.1080/1744666X.2017.1377072DOI Listing
November 2017
13 Reads

Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model.

Clin Immunol 2017 10 25;183:158-166. Epub 2017 Aug 25.

Division of Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital, 1174 Jung-dong, Bucheon, Gyeonggi-do 420-767, Republic of Korea. Electronic address:

S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. To investigate the role of S100A9 in neutrophilic asthma, S100A9 levels were measured in sputum from 101 steroid-naïve asthmatics using an ELISA kit and the levels were significantly correlated with percentages of neutrophils in sputum. Intranasal administration of recombinant S100A9 markedly increased neutrophil numbers at 8h and 24h later with concomitant elevation of IL-1β, IL-17, and IFN-γ levels. Read More

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http://dx.doi.org/10.1016/j.clim.2017.08.013DOI Listing
October 2017
27 Reads

Idiopathic T cell lymphopenia identified in New York State Newborn Screening.

Clin Immunol 2017 10 8;183:36-40. Epub 2017 Jul 8.

Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Quantification of T-cell receptor excision circles (TRECs) for newborn screening for SCID has advanced the diagnosis of severe combined immune deficiency (SCID). However, it has led to the identification of infants with T cell lymphopenia without known cause. The clinical characteristics, appropriate laboratory monitoring, and outcomes of patients remain unclear. Read More

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http://dx.doi.org/10.1016/j.clim.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736366PMC
October 2017
15 Reads

Anaphylaxis: epidemiology, aetiology and relevance for the clinic.

Expert Rev Clin Immunol 2017 09 7;13(9):889-895. Epub 2017 Jun 7.

b Primary Care Research & Development, Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics , The University of Edinburgh , Edinburgh , UK.

Introduction: Anaphylaxis is responsible for considerable morbidity and may in some cases prove fatal. Areas covered: This review summarises the findings from recent studies on the epidemiology and aetiology of anaphylaxis and draws on the insights from this work and recent international guidelines to consider the implications for clinical care. Acute management of anaphylaxis is centred on early recognition, treatment with adrenaline (epinephrine) and other essential life-support measures. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1334552DOI Listing
September 2017
18 Reads

Semaphorin 3A: Is a key player in the pathogenesis of asthma.

Clin Immunol 2017 11 11;184:70-72. Epub 2017 May 11.

Division of Allergy and Clinical immunology, Bnai-Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Immune semaphorins are key players in regulating immune mediated inflammation. Semaphorin3A (sema3A) a secreted and membrane bound member of this family, is well reported for its properties in maintaining self-tolerance. Semaphorin3A was recognized to be a marker for T-regulatory cells (Tregs), and as such is a useful tool for assessing the status of these cells in preventing immune mediated diseases. Read More

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http://dx.doi.org/10.1016/j.clim.2017.05.011DOI Listing
November 2017
6 Reads

Mold allergy: is it real and what do we do about it?

Expert Rev Clin Immunol 2017 08 17;13(8):823-835. Epub 2017 May 17.

a Division of Allergy, Asthma & Immunology , Children's Mercy Hospitals & Clinics , Kansas City , MO , USA.

Introduction: fungi produce substances that contain pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) which bind to pattern recognition receptors, stimulating innate immune responses in humans. they also produce allergens that induce production of specific ige. Areas covered: In this review we cover both innate and adaptive immune responses to fungi. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1324298DOI Listing
August 2017
3 Reads

Immunotherapy coming of age: notable advances during the first hundred years.

Authors:
Harold S Nelson

Expert Rev Clin Immunol 2017 05 15;13(5):389-392. Epub 2017 Feb 15.

a Department of Medicine, Division of Allergy/Immunology , National Jewish Health , Denver , CO , USA.

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http://dx.doi.org/10.1080/1744666X.2017.1292136DOI Listing
May 2017
5 Reads

Benralizumab for the treatment of asthma.

Expert Rev Clin Immunol 2017 05 19;13(5):405-413. Epub 2017 Apr 19.

a Division of Allergy and Immunology, Department of Internal Medicine , University of South Florida Morsani College of Medicine and James A. Haley Veterans Affairs Medical Center , Tampa , FL , USA.

Introduction: The classification of asthma into phenotypes and endotoypes allows for the use of targeted therapies, including three biologics which target interleukin 5 (IL-5) signaling in eosinophilic asthma. Areas covered: As of December 2016, two monoclonal antibodies, mepolizumab and reslizumab, are approved by U.S. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1316194DOI Listing
May 2017
3 Reads

Inflammatory biomarkers for asthma endotyping and consequent personalized therapy.

Expert Rev Clin Immunol 2017 07 11;13(7):715-721. Epub 2017 Apr 11.

c Department of Clinical and Biological Sciences , University of Torino , Turin , Italy.

Introduction: We argue that asthma be considered a syndrome caused by multiple inflammatory pathogenic processes. Bronchial hyperresponsiveness, reversible airflow limitation, and chronic airway inflammation characterize asthma pathophysiology. Personalized Medicine, i. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2017.1
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http://dx.doi.org/10.1080/1744666X.2017.1313117DOI Listing
July 2017
14 Reads

Commonality of the IL-4/IL-13 pathway in atopic diseases.

Expert Rev Clin Immunol 2017 05 15;13(5):425-437. Epub 2017 Mar 15.

c Project Direction , Regeneron Pharmaceuticals, Inc. , Tarrytown , New York , USA.

Introduction: Allergy results from an aberrant Type 2 inflammatory response, triggered by a wide range of environmental antigens (allergens) that lead to various immune responses, culminating in the production of immunoglobulin E (IgE). Two key cytokines, interleukin (IL)-4 and IL-13, are critical to the induction and perpetuation of the Type 2 response, and have been implicated in multiple atopic diseases. Area covered: This review summarizes recent milestone developments that have elucidated components of the pathogenesis of atopic diseases such as atopic dermatitis (AD), asthma, and chronic sinusitis with nasal polyposis (CSwNP). Read More

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http://dx.doi.org/10.1080/1744666X.2017.1298443DOI Listing
May 2017
10 Reads

Mite allergens.

Authors:
Luis Caraballo

Expert Rev Clin Immunol 2017 04 13;13(4):297-299. Epub 2017 Feb 13.

a Institute for Immunological Research , University of Cartagena , Cartagena , Colombia.

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http://dx.doi.org/10.1080/1744666X.2017.1292132DOI Listing
April 2017
5 Reads

Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma.

Clin Immunol 2017 03 14;176:94-99. Epub 2017 Jan 14.

Pulmonary & Critical Care Section, Department of Veterans Affairs San Diego Healthcare System (VASDHS), La Jolla, CA, United States; Division of Pulmonary & Critical Care Medicine, University of California at San Diego, La Jolla, CA, United States. Electronic address:

Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammation and is upregulated in alveolar macrophages and lung parenchyma in asthma. HIF-1α regulates select pathways in allergic inflammation, and thus may drive particular asthma phenotypes. This work examines the role of pharmacologic HIF-1α inhibition in allergic inflammatory airway disease (AIAD) pathogenesis in BALB/c mice, which develop an airway hyperresponsiveness (AHR) asthma phenotype. Read More

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http://dx.doi.org/10.1016/j.clim.2017.01.002DOI Listing
March 2017
22 Reads

Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap.

Expert Rev Clin Immunol 2017 05 26;13(5):449-455. Epub 2016 Dec 26.

a Department of Respiratory and Sleep Medicine , Royal Prince Alfred Hospital , Sydney , Australia.

Introduction: Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) ('asthma-COPD overlap') experience greater symptom burden and higher risk of adverse health outcomes than those with asthma or COPD alone. However, virtually no pharmacotherapy studies have been performed in this overlap population, leading to confusion amongst clinicians regarding therapeutic approaches. Areas covered: A pragmatic approach is suggested to identify patients with typical asthma, typical COPD, and those with overlap features. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1273109DOI Listing
May 2017
10 Reads

Allergies - A T cells perspective in the era beyond the T1/T2 paradigm.

Clin Immunol 2017 01 12;174:73-83. Epub 2016 Nov 12.

German Academic Scholarship Foundation - Studienstiftung des deutschen Volkes, Bonn, Germany.

Allergic diseases have emerged as a major health care burden, especially in the western hemisphere. They are defined by overshooting reactions of an aberrant immune system to harmless exogenous stimuli. The T1/T2 paradigm assumes that a dominance of T2 cell activation and an inadequate T1 cell response are responsible for the development of allergies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616163011
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http://dx.doi.org/10.1016/j.clim.2016.11.001DOI Listing
January 2017
7 Reads

Asthma phenotypes in childhood.

Expert Rev Clin Immunol 2017 07 18;13(7):705-713. Epub 2016 Nov 18.

b Department of Paediatrics , Imperial College of Science, Technology & Medicine , London , UK.

Introduction: Asthma is no longer thought of as a single disease, but rather a collection of varying symptoms expressing different disease patterns. One of the ongoing challenges is understanding the underlying pathophysiological mechanisms that may be responsible for the varying responses to treatment. Areas Covered: This review provides an overview of our current understanding of the asthma phenotype concept in childhood and describes key findings from both conventional and data-driven methods. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1257940DOI Listing
July 2017
6 Reads

A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model.

Clin Immunol 2016 Dec 24;173:10-18. Epub 2016 Oct 24.

Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and anaphylaxis development. We repeatedly observed non-responder animals protected from food allergy. Here, we aimed to analyse reasons for this protection. Read More

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http://dx.doi.org/10.1016/j.clim.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464391PMC
December 2016
30 Reads

300 IR HDM tablet: a sublingual immunotherapy tablet for the treatment of house dust mite-associated allergic rhinitis.

Expert Rev Clin Immunol 2016 Nov 29;12(11):1141-1151. Epub 2016 Sep 29.

e Allergy-Centre Charité , Charité-Universitätsmedizin Berlin , Berlin , Germany.

Introduction: The once-daily 300 index of reactivity (IR) house dust mite (HDM) tablet (Actair®; Stallergenes Greer, Antony, France/Shionogi & Co. Ltd., Osaka, Japan) is the first sublingual immunotherapy (SLIT) tablet to be approved for the treatment of HDM-induced allergic rhinitis. Read More

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http://dx.doi.org/10.1080/1744666X.2016.1237288DOI Listing
November 2016
7 Reads

New developments in work-related asthma.

Expert Rev Clin Immunol 2017 Mar 30;13(3):271-281. Epub 2016 Sep 30.

g Unidad de Gestión Clínica Alergología , Hospital Virgen Macarena , Sevilla , Spain.

Introduction: Work-related asthma includes two subtypes: occupational asthma or asthma caused by specific agents (sensitizers or irritants) in the workplace, and work-exacerbated asthma or pre-existing asthma worsened by workplace exposures. Areas covered: This review provides an update on the definitions and the clinical features of the different work-related asthma subtypes as well as new insights into their etiology and the pathophysiological mechanisms involved. The diagnosis of work-related asthma should be made on objective basis using a constellation of clinical, physiologic and allergologic tests. Read More

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http://dx.doi.org/10.1080/1744666X.2017.1239529DOI Listing
March 2017
19 Reads

Allergic bronchopulmonary aspergillosis in asthma.

Authors:
Alan P Knutsen

Expert Rev Clin Immunol 2017 01 22;13(1):11-14. Epub 2016 Sep 22.

a Division of Allergy & Immunology, Department of Pediatrics , Saint Louis University , St. Louis , MO , USA.

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http://dx.doi.org/10.1080/1744666X.2017.1232620DOI Listing
January 2017

Biologics targeting IL-5, IL-4 or IL-13 for the treatment of asthma - an update.

Authors:
Garry M Walsh

Expert Rev Clin Immunol 2017 Feb 2;13(2):143-149. Epub 2016 Aug 2.

a School of Medicine and Dentistry , University of Aberdeen , Scotland , UK.

Introduction: The development of monoclonal antibody-based biologics targeted at inhibition of the Th2 cytokines IL-4, IL-5 and IL-13 represent potentially effective treatments for patients with the glucocorticoid refractory eosinophilic asthma phenotype. Areas covered: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease. It is becoming apparent that significant clinical effects with anti-cytokine-based biologic therapies are more likely in carefully selected patient populations that take asthma phenotypes into account. Read More

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http://dx.doi.org/10.1080/1744666X.2016.1216316DOI Listing
February 2017
3 Reads

The role of interleukin 5 in asthma.

Expert Rev Clin Immunol 2016 09 25;12(9):903-5. Epub 2016 Jul 25.

b Allergy & Respiratory Diseases, DIMI Dept of Internal Medicine , University of Genoa, IRCCS AOU San Martino-IST , Genoa , Italy.

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http://dx.doi.org/10.1080/1744666X.2016.1208564DOI Listing
September 2016
8 Reads

Efficacy and safety of SQ house dust mite (HDM) SLIT-tablet treatment of HDM allergic asthma.

Expert Rev Clin Immunol 2016 Aug 1;12(8):805-15. Epub 2016 Jul 1.

e Allergy Clinic , Copenhagen University Hospital Gentofte , Hellerup , Denmark.

Introduction: In the treatment of house dust mite (HDM) respiratory allergic disease, allergy immunotherapy constitutes an add-on treatment option targeting the underlying immunological mechanisms of allergic disease. However, for the treatment of HDM allergic asthma, the use of subcutaneous allergy immunotherapy (SCIT) has been limited by the risk of systemic adverse events. Thus, sublingually administered allergy immunotherapy (SLIT) has been investigated as a treatment option with an improved tolerability profile that allows for safer treatment of patients with HDM allergic asthma. Read More

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http://dx.doi.org/10.1080/1744666X.2016.1200467DOI Listing
August 2016
2 Reads

Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forward.

Expert Rev Clin Immunol 2016 Jun 4;12(6):625-39. Epub 2016 Mar 4.

a International Inflammation (in-FLAME) network of the World Universities Network.

Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Read More

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2016.11
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http://dx.doi.org/10.1586/1744666X.2016.1147955DOI Listing
June 2016
19 Reads

Clinical presentation, allergens, and management of wheat allergy.

Expert Rev Clin Immunol 2016 11;12(5):563-72. Epub 2016 Feb 11.

c Centro de Biotecnología y Genómica de Plantas (UPM-INIA) , Pozuelo de Alarcón , Madrid , Spain.

IgE-mediated allergy to wheat proteins can be caused by exposure through ingestion, inhalation, or skin/mucosal contact, and can affect various populations and age groups. Respiratory allergy to wheat proteins is commonly observed in adult patients occupationally exposed to flour, whereas wheat food allergy is more common in children. Wheat allergy is of growing importance for patients with recurrent anaphylaxis, especially when exercise related. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1145548DOI Listing
January 2017
7 Reads

The spectrum of allergic fungal diseases of the upper and lower airways.

Expert Rev Clin Immunol 2016 19;12(5):531-50. Epub 2016 Feb 19.

a Allergy & Immunology , Saint Louis University , St. Louis , MO , USA.

Fungi cause a wide spectrum of fungal diseases of the upper and lower airways. There are three main phyla involved in allergic fungal disease: (1) Ascomycota (2) Basidiomycota (3) Zygomycota. Allergic fungal rhinosinusitis (AFRS) causes chronic rhinosinusitis symptoms and is caused predominantly by Aspergillus fumigatus in India and Bipolaris in the United States. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1142874DOI Listing
January 2017
9 Reads

Allergies and Asthma: Do Atopic Disorders Result from Inadequate Immune Homeostasis arising from Infant Gut Dysbiosis?

Expert Rev Clin Immunol 2016 7;12(4):379-88. Epub 2016 Feb 7.

b Department of Pediatrics , Georgia Regents University , Augusta , GA , USA.

Our global hypothesis is that atopic conditions and asthma develop because an individual's immune system is not able to appropriately resolve inflammation resulting from allergen exposures. We propose that the failure to appropriately down-regulate inflammation and produce a toleragenic state results primarily from less robust immune homeostatic processes rather than from a tendency to over-respond to allergenic stimuli. An individual with lower immune homeostatic capacity is unable to rapidly and completely terminate, on average over time, immune responses to innocuous allergens, increasing risk of allergic disease. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1139452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829075PMC
December 2016
16 Reads

An Overview of Fractional Exhaled Nitric Oxide and Children with Asthma.

Expert Rev Clin Immunol 2016 19;12(5):521-30. Epub 2016 Feb 19.

b The Channing Division of Network Medicine , Brigham and Women's Hospital , Boston , MA , USA.

Asthma is the most common pediatric chronic disease and is characterized by lung inflammation. Fractional exhaled nitric oxide (FeNO) is thought to reflect the presence of eosinophilic airway inflammation, and is an easy, non-invasive test that has held promise in providing additional objective data. However, not all studies have shown a clinical benefit in the use of FeNO to guide management of asthma in children. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1141049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837084PMC
January 2017
2 Reads

Intermittent steroid inhalation for the treatment of childhood asthma.

Expert Rev Clin Immunol 2016 11;12(2):183-94. Epub 2015 Nov 11.

a Section of Pediatric Pulmonology , University of Colorado School of Medicine , Aurora , CO , USA.

Inhaled corticosteroids have long been considered a mainstay of therapy for asthma in children. However, concerns over long-term side effects of chronic steroid administration have led providers to turn to intermittent dosing of these medications in an attempt to treat exacerbations while limiting total corticosteroid received. The data have been somewhat mixed in this area, likely at least partially due to the difficulty providers have in classifying asthma phenotypes in young children. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1105741DOI Listing
November 2016
11 Reads

Beclomethasone dipropionate hydrofluoroalkane for the treatment of allergic rhinitis.

Expert Rev Clin Immunol 2016 11;12(3):279-88. Epub 2015 Dec 11.

b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.

Allergic rhinitis (AR) is a common respiratory disease, and its prevalence is increasing all over the world, both in adults and in children. Patients experience symptoms that may negatively impact on physical, social and psychological well-being. Hence, if left untreated, allergic rhinitis may significantly affect quality of life. Read More

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http://dx.doi.org/10.1586/1744666X.2016.1118347DOI Listing
December 2016
3 Reads

Efficacy and safety of sublingual immunotherapy in children.

Expert Rev Clin Immunol 2016 23;12(1):49-56. Epub 2015 Oct 23.

a Department of Pediatrics- Allergy Unit , University of Messina , Messina , Italy.

Allergen immunotherapy (AIT) is currently the only available disease-modifying and aetiological treatment of IgE-mediated diseases. Sublingual allergen immunotherapy (SLIT) constitutes the preferred route of administration of AIT for respiratory allergies in Europe. Recently it has also been approved in the US. Read More

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2016.11
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http://dx.doi.org/10.1586/1744666X.2016.1102058DOI Listing
August 2016
12 Reads

Management of allergic disease in the elderly: key considerations, recommendations and emerging therapies.

Expert Rev Clin Immunol 2015 7;11(11):1219-28. Epub 2015 Sep 7.

e 5 Department of Clinical and Experimental Medicine, University of Parma , via Gramsci 14, 43120 Parma, Italy.

The number of people over 65 is increasing around the world. At present, between 5 and 10% of allergic diseases affect the elderly. In particular, rhinitis is increasing worldwide; the presence of high comorbidity makes the therapy of asthma even more complicated. Read More

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2015.10
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http://dx.doi.org/10.1586/1744666X.2015.1081564DOI Listing
August 2016
2 Reads

Asthma in the older adult: presentation, considerations and clinical management.

Expert Rev Clin Immunol 2015 10;11(12):1297-308. Epub 2015 Sep 10.

a Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.MIS), University of Palermo Palermo, Italy.

Asthma affects older adults to the same extent as children and adolescents. However, one is led to imagine that asthma prevalence decreases with aging and becomes a rare entity in the elderly. From a clinical perspective, this misconception has nontrivial consequences in that the recognition of the disease is delayed and the treatment postponed. Read More

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http://dx.doi.org/10.1586/1744666X.2015.1087850DOI Listing
August 2016
4 Reads

From IgE to clinical trials of allergic rhinitis.

Expert Rev Clin Immunol 2015 10;11(12):1321-33. Epub 2015 Sep 10.

b 2 Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

The current scientific research is continuously aiming at identifying new therapeutic targets with the purpose of modifying the immune response to allergens. The evolution in immunological methods has led to the identification of immunoglobulin E (IgE) as both a diagnostic biomarker and potential therapeutic target in allergic diseases, such as allergic rhinitis. Allergen immunotherapy has been used for more than 100 years to treat allergic diseases and it is today considered the only disease-modifying treatment capable of inducing a long-lasting immunological and clinical tolerance toward the causal allergen. Read More

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http://dx.doi.org/10.1586/1744666X.2015.1086645DOI Listing
August 2016
6 Reads

Omalizumab therapy for children and adolescents with severe allergic asthma.

Authors:
Ciro Romano

Expert Rev Clin Immunol 2015 27;11(12):1309-19. Epub 2015 Aug 27.

a Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medical and Surgical Sciences, Second University of Naples School of Medicine, Piazza Miraglia 3, 80138 Naples, Italy.

Omalizumab, a therapeutic humanized monoclonal antibody specific for human IgE, was introduced in clinical practice more than a decade ago as an add-on therapy for moderate-to-severe allergic asthma in patients aged ≥12 years. Omalizumab has been demonstrated to be effective in adults with uncontrolled persistent asthma, with an excellent safety profile. In simple terms, omalizumab works by inhibiting the allergic cascade, that is, by neutralization of the circulating free IgE. Read More

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http://dx.doi.org/10.1586/1744666X.2015.1083860DOI Listing

Novel imaging approaches in adult asthma and their clinical potential.

Expert Rev Clin Immunol 2015 7;11(10):1147-62. Epub 2015 Aug 7.

a 1 Department of Infection, Inflammation and Immunity, Institute for Lung Health, University of Leicester, Leicester, LE3 9QP, UK.

Currently, imaging in asthma is confined to chest radiography and CT. The emergence of new imaging techniques and tremendous improvement of existing imaging methods, primarily due to technological advancement, has completely changed its research and clinical prospects. In research, imaging in asthma is now being employed to provide quantitative assessment of morphology, function and pathogenic processes at the molecular level. Read More

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http://dx.doi.org/10.1586/1744666X.2015.1072049DOI Listing
June 2016
1 Read
2 Citations
3.340 Impact Factor

Mold elicits atopic dermatitis by reactive oxygen species: Epidemiology and mechanism studies.

Clin Immunol 2015 Dec 21;161(2):384-90. Epub 2015 Jul 21.

Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Research Center for Standardization of Allergic Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Mold has been implicated in the development of atopic dermatitis (AD); however, the underlying mechanisms remain unknown. The aim of the study was to investigate the effects of mold exposure in early life through epidemiologic and mechanistic studies in vivo and in vitro. Exposure to visible mold inside the home during the first year of life was associated with an increased risk for current AD by two population-based cross-sectional human studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616153001
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http://dx.doi.org/10.1016/j.clim.2015.07.007DOI Listing
December 2015
5 Reads

Utilizing social networks, blogging and YouTube in allergy and immunology practices.

Expert Rev Clin Immunol 2015 10;11(10):1065-8. Epub 2015 Jul 10.

b 2 Cleveland Clinic Florida - Department of Allergy and Immunology 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA.

Online social networks are used to connect with friends and family members, and increasingly, to stay up-to-date with the latest news and developments in allergy and immunology. As communication is a central part of healthcare delivery, the utilization of such networking channels in allergy and immunology will continue to grow. There are inherent risks to online social networks related to breaches of patient confidentiality, professionalism and privacy. Read More

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2015.10
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http://dx.doi.org/10.1586/1744666X.2015.1065731DOI Listing
June 2016
6 Reads