203 results match your criteria Allergy Asthma And Clinical Immunology[Journal]


Food allergy severity prediction: quite a way to go yet?

Expert Rev Clin Immunol 2020 May 14. Epub 2020 May 14.

Department of Women and Children's Health (Paediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1770083DOI Listing

Epithelial-macrophage-dendritic cell interactions impact alarmins expression in asthma and COPD.

Clin Immunol 2020 Apr 14;215:108421. Epub 2020 Apr 14.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Poland.

In the respiratory system macrophages and dendritic cells collaborate as sentinels against foreign particulate antigens. The study used a triple-cell co-culture model, utilizing nasal epithelial cells, along with: monocyte derived macrophages (moMφs), and monocyte derived DCs (moDCs). Cell cultures from 15 controls, 14 asthma and 11 COPD patients were stimulated with IL-13 and poly I:C for 24 h. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2020.108421DOI Listing

Hypersensitivity and adverse reactions to biologics for asthma and allergic diseases.

Expert Rev Clin Immunol 2020 Mar 8;16(3):311-319. Epub 2020 Feb 8.

Allergy and Immunology Section, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

: The development of new biologic agents has provided definite therapeutic advances but, like with any new medications, safety remains a concern.: Using PubMed, we reviewed the literature on the adverse effects (AE) to five biologics approved for asthma and/or allergic diseases: one anti-IgE (omalizumab), three anti-IL5 (mepolizumab, reslizumab, benralizumab), and one anti-IL4 (dupilumab).: Biologic agents approved for asthma and allergic diseases are generally safe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1724089DOI Listing

Obstructive lung diseases and risk of rheumatoid arthritis.

Expert Rev Clin Immunol 2020 Jan 6;16(1):37-50. Epub 2020 Jan 6.

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA, USA.

: Smoking is an established risk factor for both lung diseases and rheumatoid arthritis (RA). Chronic mucosal airway inflammation may result in immune tolerance loss, neoantigen formation, and production of RA-related autoantibodies that increase the subsequent risk of RA. In this review, we aimed to summarize the current evidence supporting the role of obstructive lung diseases and subsequent risk of RA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2019.1698293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980732PMC
January 2020

Evaluation of the epidemiology of peanut allergy in the United Kingdom.

Expert Rev Clin Immunol 2019 12 27;15(12):1333-1339. Epub 2019 Nov 27.

Global Epidemiology, Pharmatelligence, Cardiff, UK.

: To describe the epidemiology of peanut allergy (PA) in the UK over the last three decades.: PA patients were identified from the Clinical Practice Research Datalink between 1987 and 2015. Incidence and prevalence of PA were compared between 2000 and 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1693264DOI Listing
December 2019

The pediatric asthma risk score (PARS): making the move to the most accurate pediatric asthma risk screening tool.

Expert Rev Clin Immunol 2019 11 24;15(11):1115-1118. Epub 2019 Oct 24.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1682552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837242PMC
November 2019

SQ house dust mite sublingual immunotherapy for the treatment of adults with house dust mite-induced allergic rhinitis.

Expert Rev Clin Immunol 2019 11 22;15(11):1127-1133. Epub 2019 Oct 22.

Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark.

: Allergic rhinitis (AR) is one of the most common chronic conditions affecting both children and adults. The house dust mites (HDM) account for a substantial part of the overall sources of allergens. In patients where allergen avoidance and symptom-relieving pharmacotherapy do not provide adequate disease control, specific allergen immunotherapy (AIT) is indicated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1676731DOI Listing
November 2019
2 Reads

What have recent advances in therapy taught us about severe asthma disease mechanisms?

Expert Rev Clin Immunol 2019 11 18;15(11):1145-1153. Epub 2019 Oct 18.

UMKC School of Medicine, KC, MO, USA.

: Severe asthma still represents a worldwide challenge. The need for further treatment options has stimulated basic and pharmacological research to focus on the immune and inflammatory background of asthma. The new biologic drugs express the considerable advances in the field and besides providing a revolutionary treatment option for severe asthma, contribute themselves to better understand the pathophysiologic mechanisms they address, paving the way to new potential targets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1672536DOI Listing
November 2019
4 Reads

Allergen-induced asthma, chronic rhinosinusitis and transforming growth factor-β superfamily signaling: mechanisms and functional consequences.

Expert Rev Clin Immunol 2019 11 19;15(11):1155-1170. Epub 2019 Oct 19.

Department of Rhinology, Royal National ENT Hospital, University College London Hospitals NHS Foundation Trust, London, UK.

: Often co-associated, asthma and chronic rhinosinusitis (CRS) are complex heterogeneous disease syndromes. Severity in both is related to tissue inflammation and abnormal repair (termed remodeling). Understanding signaling factors that can modulate, integrate the activation, and regulation of such key processes together is increasingly important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2020.1672538DOI Listing
November 2019
1 Read

The spectrum of therapeutic activity of mepolizumab.

Expert Rev Clin Immunol 2019 09 29;15(9):959-967. Epub 2019 Aug 29.

Cardiac/Pulmonary Rehabilitation, ASST Pini/CTO , Milan , Italy.

: The basis of the development of the anti-interleukin-5 monoclonal antibody mepolizumab was the acknowledgment of the crucial importance of this cytokine in promoting eosinophils production, activation, and survival, which is associated with the eosinophilic asthma phenotype, as well as with other disorders characterized by high levels of eosinophils. : All the available literature on the outcomes treatment with mepolizumab in eosinophilic disorders are reviewed, including asthma, chronic rhinosinusitis, esophagitis, granulomatosis with polyangiitis, eosinophilic chronic obstructive pulmonary disease, hypereosinophilic syndrome, and allergic bronchopulmonary aspergillosis. : The efficacy of mepolizumab in eosinophilic asthma is clearly demonstrated by a number of controlled trials and by meta-analyses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2019.1656065DOI Listing
September 2019
6 Reads
3.342 Impact Factor

Real-life studies of biologics used in asthma patients: key differences and similarities to trials.

Expert Rev Clin Immunol 2019 09 12;15(9):951-958. Epub 2019 Aug 12.

Department of Biomedical Sciences, Humanitas University , Pieve Emanuele , Italy.

: The precision medicine approach that is now mandatory for severe asthma management includes the use of novel biologic agents blocking specific immunological mechanisms that are responsible for disease phenotypes and endotypes: monoclonal antibodies blocking IgE, IL-5 and IL-4/IL-13 immunological pathways are so far available. : Clinical trials involving a large number of patients proved their efficacy in reducing asthma exacerbations, improving lung function and quality of life, and reducing the need for systemic corticosteroid treatment. Since biologics have been available for routine use, a series of real-life experiences on severe asthmatics treated with them have been published: these studies confirmed the beneficial effects in a real-world setting (effectiveness) of these drugs and showed novel aspects that were not covered by clinical trials, such as their effect on particular subgroup of patients, unexpected adverse events, and potential novel indications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2019.1653758DOI Listing
September 2019

Serum leptin levels correlate negatively with the capacity of vitamin D to modulate the in vitro cytokines production by CD4 T cells in asthmatic patients.

Clin Immunol 2019 08 4;205:93-105. Epub 2019 Jun 4.

Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Brazil. Electronic address:

Both obesity and low vitamin D levels have been associated with allergic asthma (AA) severity. In the present study, severity of AA was associated with obesity but to the in vitro IgE production. In those patients, higher levels of IL-5, IL-6 and IL-17 were quantified in CD4 T-cell cultures as compared with patients with mild and moderate AA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.06.001DOI Listing
August 2019
10 Reads

Evaluation of the frequency of invariant natural killer T (iNKT) cells in nasal polyps.

Clin Immunol 2019 08 29;205:125-129. Epub 2019 May 29.

Division of Gastroenterology, Endoscopy, and Hepatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Manchester Collaborative Centre for Inflammation Research, University of Manchester, UK. Electronic address:

Nasal polyps (NP) are associated with inflamed mucosa of unknown etiology. The role of T cells in nasal polyposis is unclear. Invariant natural killer T cells (iNKT) can promote Th2 responses and have been implicated in some types of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2019.05.013DOI Listing
August 2019
4 Reads
3.672 Impact Factor

iNKT cells and hematopoietic stem cell transplantation: Two-phase activation of iNKT cells may improve outcome.

Clin Immunol 2019 10 23;207:43-48. Epub 2019 May 23.

Division of Gastroenterology, Endoscopy, and Hepatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Manchester Collaborative Centre for Inflammation Research, University of Manchester, UK. Electronic address:

Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity. There are highly specific and safe synthetic ligands such as alpha-galactosylceramide (α-GalCer) and C20:2 which activate iNKT cells toward relatively Th1 and Th2 pathways, respectively. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15216616193007
Publisher Site
http://dx.doi.org/10.1016/j.clim.2019.05.011DOI Listing
October 2019
4 Reads
3.672 Impact Factor

Post-viral atopic airway disease: pathogenesis and potential avenues for intervention.

Expert Rev Clin Immunol 2019 01 3;15(1):49-58. Epub 2018 Nov 3.

a Division of Allergy and Immunology , Nationwide Children's Hospital - The Ohio State University College of Medicine , Columbus , OH , USA.

: In early childhood, wheezing due to lower respiratory tract illness is often associated with infection by commonly known respiratory viruses such as respiratory syncytial virus (RSV) and human rhinovirus (RV). How respiratory viral infections lead to wheeze and/or asthma is an area of active research. : This review provides an updated summary of the published information on the development of post-viral induced atopy and asthma and the mechanisms involved. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2019.1541737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486879PMC
January 2019
37 Reads

Chronic rhinosinusitis with nasal polyps: insights into mechanisms of disease from emerging biological therapies.

Expert Rev Clin Immunol 2019 01 5;15(1):59-71. Epub 2018 Nov 5.

a Rhinology Section, Specialist Allergy and Clinical Immunology , Royal National Throat Nose and Ear Hospital London and University College London Hospital NHS Foundation Trust, University College London , London , UK.

: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex disease of the upper airway, with long-term morbidity. With detailed mechanistic studies currently lacking, understanding of the immunopathogenesis is still limited. However, outcomes from CRSwNP clinical studies using biologics that block key mediators or cells may provide some insights into how immune signaling pathways potentially integrate and modulate each other and contribute to disease. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2019.1541738DOI Listing
January 2019
27 Reads

Stress, mindfulness, and the allergic patient.

Expert Rev Clin Immunol 2018 12 20;14(12):1065-1079. Epub 2018 Oct 20.

b Department of Psychology , The University of Toledo , Toledo , OH , USA.

Introduction: The global incidence and prevalence of allergic diseases are increasing as is the intensity and duration of excessive psychological stress due to multiple factors associated with living in today's world such as personal, social and political unrest, increased fear and anxiety, and/or depression often leading to hopelessness. Both allergy and chronic psychological stress are characterized by immune imbalances that have similar characteristics. Thus, it is reasonable to posit that the two are interactive and stress may induce as well as complicate at least some allergic diseases. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2018.1536547DOI Listing
December 2018
24 Reads

Adherence to medication in children and adolescents with asthma: methods for monitoring and intervention.

Expert Rev Clin Immunol 2018 12 15;14(12):1055-1063. Epub 2018 Oct 15.

b National Heart and Lung Institute , Imperial College , London , UK.

Introduction: Poor adherence in children with asthma is a major cause of asthma attacks and poor control, leads to large health-care costs, and has been identified as a factor in asthma deaths. However, it is difficult to detect and frequently overlooked leading to inappropriate escalation of asthma treatment. There is a need for cost effective ways to monitor adherence in order to intervene to change this modifiable behavior. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2018.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2018.1532290DOI Listing
December 2018
20 Reads

The association between early life antibiotic use and allergic disease in young children: recent insights and their implications.

Expert Rev Clin Immunol 2018 10 29;14(10):841-855. Epub 2018 Sep 29.

a School of Public Health , University of Alberta , Edmonton , Canada.

Introduction: Greater prescribing of antibiotics to infants has coincided with an epidemic of allergic disease. Through meta-analytic synthesis, accumulating evidence from prospective or database cohorts suggests a link between infant antibiotic treatment and the development of atopy. Stronger associations seen with multiple course and broad-spectrum antibiotic treatment add to biological plausibility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1521271DOI Listing
October 2018
4 Reads

Acid suppressant medications and the risk of allergic diseases.

Expert Rev Clin Immunol 2018 09 24;14(9):771-780. Epub 2018 Aug 24.

a Division of Rheumatology, Allergy and Immunology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA.

Introduction: Acid suppressant medications (ASMs), such as proton pump inhibitors and histamine-2 receptor antagonists, are used often and throughout the lifespan. These medications have been linked to the development of a variety of allergic diseases. Areas covered: This review discusses prior studies investigating the association between acid ASM exposure and the development of allergic diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1512405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332498PMC
September 2018
53 Reads
3.342 Impact Factor

Immunological mechanisms underlying chronic rhinosinusitis with nasal polyps.

Expert Rev Clin Immunol 2018 09 22;14(9):731-737. Epub 2018 Aug 22.

a Personalized Medicine , Asthma and Allergy - Humanitas Research Hospital , Milan , Italy.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common and quality-of-life impacting disorder, with an underlying immunological mechanism similar to other conditions such as eosinophilic asthma or atopic eczema. Areas covered: This review article summarizes the most recent evidence on the main immunological mechanisms involved in the pathogenesis and the perpetuation of CRSwNP, with a particular focus on the key role of epithelium-derived inflammation as a consequence of the interaction with the airborne environment. Expert commentary: The increase in knowledge of the immunology of CRSwNP leads to the development of therapeutical strategies based upon the use of biologic agents that, according to a personalized and precision medicine approach, will provide each single patient with the most suitable immunological treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1512407DOI Listing
September 2018
6 Reads

Biomarkers of immunotherapy response in patients with allergic rhinitis.

Expert Rev Clin Immunol 2018 08 31;14(8):657-663. Epub 2018 Jul 31.

b Pediatric Allergy , IRCCS Istituto Giannina Gaslini , Genoa , Italy.

Introduction: Allergen immunotherapy represents the only disease-modifying therapy available for immunoglobulin E-mediated diseases such as allergic rhinitis and asthma. Allergen immunotherapy induces allergen tolerance by interfering with the immune-pathogenic mechanisms of the allergic response and is potentially able to provide long-term relief of symptoms of allergic rhinitis and asthma and alter the natural course of allergic diseases. Areas covered: Since allergen immunotherapy (AIT) is actually considered an individualized treatment on patient's clinical and immunological profile, the identification of specific biomarkers, which may guide diagnosis, management, and predict response to AIT treatment in allergic rhinitis (AR) patients, is essential and is currently an active field of research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1504679DOI Listing
August 2018
7 Reads

The nasal microbiome: opening new clinical research avenues for allergic disease.

Expert Rev Clin Immunol 2018 08 25;14(8):645-647. Epub 2018 Jul 25.

a Allergy and Immunology Division, Department of Internal Medicine , Rush University Medical Center , Chicago , IL , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1500177DOI Listing
August 2018
9 Reads

New biologics for allergic diseases.

Expert Rev Clin Immunol 2018 04 10;14(4):285-296. Epub 2018 Apr 10.

b The Cohen Family Asthma Institute, Division of Pulmonary, Critical Care, and Sleep Medicine , National Jewish Health , Denver , CO , USA.

Introduction: Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1459188DOI Listing
April 2018
13 Reads

Targeting the exposome: does correcting vitamin D deficiency have potential to treat and prevent asthma?

Authors:
Paul E Pfeffer

Expert Rev Clin Immunol 2018 04 20;14(4):241-243. Epub 2018 Feb 20.

a William Harvey Research Institute, Barts and The London School of Medicine and Dentistry , Queen Mary University of London , London , UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2018.1440207DOI Listing
April 2018
4 Reads

Circulating IL-17-producing mucosal-associated invariant T cells (MAIT) are associated with symptoms in children with asthma.

Clin Immunol 2018 03 28;188:7-11. Epub 2017 Nov 28.

Université Paris Descartes, Paris, France; Laboratory of Immunoregulation and Immunopathology, INEM (Institut Necker-Enfants Malades), CNRS UMR8253, and INSERM UMR1151, Paris, France. Electronic address:

IL-17 and mucosal-associated invariant T (MAIT) cells have been involved in asthma pathogenesis. However, IL-17-producing MAIT cells (MAIT-17) were not evidenced. We aimed to determine whether circulating MAIT-17 were detectable in children with asthma, and whether they correlated with asthma symptoms or lung function. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15216616173043
Publisher Site
http://dx.doi.org/10.1016/j.clim.2017.11.009DOI Listing
March 2018
29 Reads

Grass pollen sublingual immunotherapy tablets provide long-term relief of grass pollen-associated allergic rhinitis and reduce the risk of asthma: findings from a retrospective, real-world database subanalysis.

Expert Rev Clin Immunol 2017 12 6;13(12):1199-1206. Epub 2017 Nov 6.

d Institute of Epidemiology , Helmholtz Zentrum Munich, German Research Centre for Environmental Health GmbH , Neuherberg , Germany.

Background: We assessed real-world, long-term effectiveness of two marketed sublingual immunotherapy (SLIT) tablets for allergic rhinitis (AR), and their impact on allergic asthma (AA) onset/progression.

Methods: Retrospective, longitudinal German prescription database subanalysis of AR patients receiving 5- or 1-grass pollen SLIT tablets (n = 1,466/1,385), versus patients not using allergy immunotherapy (AIT) (n = 71,275). Primary endpoint: change over time in AR symptomatic medication prescriptions after treatment cessation; secondary endpoints: new asthma onset, and change over time in asthma medication prescriptions during treatment/follow-up periods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1398082DOI Listing
December 2017
20 Reads

Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice.

Clin Immunol 2018 02 14;187:58-67. Epub 2017 Oct 14.

Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Dendritic cells (DCs) are professional antigen-presenting cells, and Notch ligand Delta-like-1 (DLL1) on DCs was implicated in type 1T helper (Th1) differentiation. In this study, we produced genetically engineered bone marrow-derived DCs that expressed DLL1 (DLL1-DCs) by adenoviral transduction. DLL1-DCs exerted a fully mature phenotype, and had positive effects on expression levels of interleukin (IL)-12 and costimulatory molecules. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.10.005DOI Listing
February 2018
5 Reads

Practical approach to the treatment of NSAID hypersensitivity.

Expert Rev Clin Immunol 2017 11 19;13(11):1017-1027. Epub 2017 Sep 19.

a Allergy Service , Hospital Infanta Leonor , Madrid , Spain.

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently involved in drug hypersensitivity reactions (DHR). NSAIDs are prescribed for different processes and some NSAIDs can be obtained over the counter. Areas covered: We analyse the practical approaches for managing and treating NSAID-DHR considering the five major groups of entities recognised, divided into two categories: those responding to strong COX-1 inhibitors and possibly weak COX-1 or selective COX-2 inhibitors named cross-intolerant (CI), and those induced by a single drug or drug group with good tolerance to strong COX-1 inhibitors, known as allergic reactions (SR). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2017.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2017.1377072DOI Listing
November 2017
22 Reads

Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model.

Clin Immunol 2017 10 25;183:158-166. Epub 2017 Aug 25.

Division of Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital, 1174 Jung-dong, Bucheon, Gyeonggi-do 420-767, Republic of Korea. Electronic address:

S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. To investigate the role of S100A9 in neutrophilic asthma, S100A9 levels were measured in sputum from 101 steroid-naïve asthmatics using an ELISA kit and the levels were significantly correlated with percentages of neutrophils in sputum. Intranasal administration of recombinant S100A9 markedly increased neutrophil numbers at 8h and 24h later with concomitant elevation of IL-1β, IL-17, and IFN-γ levels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.08.013DOI Listing
October 2017
40 Reads

Idiopathic T cell lymphopenia identified in New York State Newborn Screening.

Clin Immunol 2017 10 8;183:36-40. Epub 2017 Jul 8.

Division of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Quantification of T-cell receptor excision circles (TRECs) for newborn screening for SCID has advanced the diagnosis of severe combined immune deficiency (SCID). However, it has led to the identification of infants with T cell lymphopenia without known cause. The clinical characteristics, appropriate laboratory monitoring, and outcomes of patients remain unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736366PMC
October 2017
40 Reads

Anaphylaxis: epidemiology, aetiology and relevance for the clinic.

Expert Rev Clin Immunol 2017 09 7;13(9):889-895. Epub 2017 Jun 7.

b Primary Care Research & Development, Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics , The University of Edinburgh , Edinburgh , UK.

Introduction: Anaphylaxis is responsible for considerable morbidity and may in some cases prove fatal. Areas covered: This review summarises the findings from recent studies on the epidemiology and aetiology of anaphylaxis and draws on the insights from this work and recent international guidelines to consider the implications for clinical care. Acute management of anaphylaxis is centred on early recognition, treatment with adrenaline (epinephrine) and other essential life-support measures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1334552DOI Listing
September 2017
22 Reads

Semaphorin 3A: Is a key player in the pathogenesis of asthma.

Clin Immunol 2017 11 11;184:70-72. Epub 2017 May 11.

Division of Allergy and Clinical immunology, Bnai-Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Immune semaphorins are key players in regulating immune mediated inflammation. Semaphorin3A (sema3A) a secreted and membrane bound member of this family, is well reported for its properties in maintaining self-tolerance. Semaphorin3A was recognized to be a marker for T-regulatory cells (Tregs), and as such is a useful tool for assessing the status of these cells in preventing immune mediated diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.05.011DOI Listing
November 2017
12 Reads

Mold allergy: is it real and what do we do about it?

Expert Rev Clin Immunol 2017 08 17;13(8):823-835. Epub 2017 May 17.

a Division of Allergy, Asthma & Immunology , Children's Mercy Hospitals & Clinics , Kansas City , MO , USA.

Introduction: fungi produce substances that contain pathogen-associated molecular patterns (pamps) and damage-associated molecular patterns (damps) which bind to pattern recognition receptors, stimulating innate immune responses in humans. they also produce allergens that induce production of specific ige. Areas covered: In this review we cover both innate and adaptive immune responses to fungi. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1324298DOI Listing
August 2017
5 Reads

Immunotherapy coming of age: notable advances during the first hundred years.

Authors:
Harold S Nelson

Expert Rev Clin Immunol 2017 05 15;13(5):389-392. Epub 2017 Feb 15.

a Department of Medicine, Division of Allergy/Immunology , National Jewish Health , Denver , CO , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1292136DOI Listing
May 2017
6 Reads

Benralizumab for the treatment of asthma.

Expert Rev Clin Immunol 2017 05 19;13(5):405-413. Epub 2017 Apr 19.

a Division of Allergy and Immunology, Department of Internal Medicine , University of South Florida Morsani College of Medicine and James A. Haley Veterans Affairs Medical Center , Tampa , FL , USA.

Introduction: The classification of asthma into phenotypes and endotoypes allows for the use of targeted therapies, including three biologics which target interleukin 5 (IL-5) signaling in eosinophilic asthma. Areas covered: As of December 2016, two monoclonal antibodies, mepolizumab and reslizumab, are approved by U.S. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1316194DOI Listing
May 2017
5 Reads

Inflammatory biomarkers for asthma endotyping and consequent personalized therapy.

Expert Rev Clin Immunol 2017 07 11;13(7):715-721. Epub 2017 Apr 11.

c Department of Clinical and Biological Sciences , University of Torino , Turin , Italy.

Introduction: We argue that asthma be considered a syndrome caused by multiple inflammatory pathogenic processes. Bronchial hyperresponsiveness, reversible airflow limitation, and chronic airway inflammation characterize asthma pathophysiology. Personalized Medicine, i. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/1744666X.2017.1
Publisher Site
http://dx.doi.org/10.1080/1744666X.2017.1313117DOI Listing
July 2017
17 Reads

Commonality of the IL-4/IL-13 pathway in atopic diseases.

Expert Rev Clin Immunol 2017 05 15;13(5):425-437. Epub 2017 Mar 15.

c Project Direction , Regeneron Pharmaceuticals, Inc. , Tarrytown , New York , USA.

Introduction: Allergy results from an aberrant Type 2 inflammatory response, triggered by a wide range of environmental antigens (allergens) that lead to various immune responses, culminating in the production of immunoglobulin E (IgE). Two key cytokines, interleukin (IL)-4 and IL-13, are critical to the induction and perpetuation of the Type 2 response, and have been implicated in multiple atopic diseases. Area covered: This review summarizes recent milestone developments that have elucidated components of the pathogenesis of atopic diseases such as atopic dermatitis (AD), asthma, and chronic sinusitis with nasal polyposis (CSwNP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1298443DOI Listing
May 2017
25 Reads

Mite allergens.

Authors:
Luis Caraballo

Expert Rev Clin Immunol 2017 04 13;13(4):297-299. Epub 2017 Feb 13.

a Institute for Immunological Research , University of Cartagena , Cartagena , Colombia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1292132DOI Listing
April 2017
8 Reads

Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma.

Clin Immunol 2017 03 14;176:94-99. Epub 2017 Jan 14.

Pulmonary & Critical Care Section, Department of Veterans Affairs San Diego Healthcare System (VASDHS), La Jolla, CA, United States; Division of Pulmonary & Critical Care Medicine, University of California at San Diego, La Jolla, CA, United States. Electronic address:

Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammation and is upregulated in alveolar macrophages and lung parenchyma in asthma. HIF-1α regulates select pathways in allergic inflammation, and thus may drive particular asthma phenotypes. This work examines the role of pharmacologic HIF-1α inhibition in allergic inflammatory airway disease (AIAD) pathogenesis in BALB/c mice, which develop an airway hyperresponsiveness (AHR) asthma phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.01.002DOI Listing
March 2017
25 Reads

Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap.

Expert Rev Clin Immunol 2017 05 26;13(5):449-455. Epub 2016 Dec 26.

a Department of Respiratory and Sleep Medicine , Royal Prince Alfred Hospital , Sydney , Australia.

Introduction: Patients with features of both asthma and chronic obstructive pulmonary disease (COPD) ('asthma-COPD overlap') experience greater symptom burden and higher risk of adverse health outcomes than those with asthma or COPD alone. However, virtually no pharmacotherapy studies have been performed in this overlap population, leading to confusion amongst clinicians regarding therapeutic approaches. Areas covered: A pragmatic approach is suggested to identify patients with typical asthma, typical COPD, and those with overlap features. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1273109DOI Listing
May 2017
15 Reads

Allergies - A T cells perspective in the era beyond the T1/T2 paradigm.

Clin Immunol 2017 01 12;174:73-83. Epub 2016 Nov 12.

German Academic Scholarship Foundation - Studienstiftung des deutschen Volkes, Bonn, Germany.

Allergic diseases have emerged as a major health care burden, especially in the western hemisphere. They are defined by overshooting reactions of an aberrant immune system to harmless exogenous stimuli. The T1/T2 paradigm assumes that a dominance of T2 cell activation and an inadequate T1 cell response are responsible for the development of allergies. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15216616163011
Publisher Site
http://dx.doi.org/10.1016/j.clim.2016.11.001DOI Listing
January 2017
66 Reads

Asthma phenotypes in childhood.

Expert Rev Clin Immunol 2017 07 18;13(7):705-713. Epub 2016 Nov 18.

b Department of Paediatrics , Imperial College of Science, Technology & Medicine , London , UK.

Introduction: Asthma is no longer thought of as a single disease, but rather a collection of varying symptoms expressing different disease patterns. One of the ongoing challenges is understanding the underlying pathophysiological mechanisms that may be responsible for the varying responses to treatment. Areas Covered: This review provides an overview of our current understanding of the asthma phenotype concept in childhood and describes key findings from both conventional and data-driven methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1257940DOI Listing
July 2017
9 Reads

A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model.

Clin Immunol 2016 Dec 24;173:10-18. Epub 2016 Oct 24.

Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and anaphylaxis development. We repeatedly observed non-responder animals protected from food allergy. Here, we aimed to analyse reasons for this protection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2016.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464391PMC
December 2016
46 Reads

300 IR HDM tablet: a sublingual immunotherapy tablet for the treatment of house dust mite-associated allergic rhinitis.

Expert Rev Clin Immunol 2016 Nov 29;12(11):1141-1151. Epub 2016 Sep 29.

e Allergy-Centre Charité , Charité-Universitätsmedizin Berlin , Berlin , Germany.

Introduction: The once-daily 300 index of reactivity (IR) house dust mite (HDM) tablet (Actair®; Stallergenes Greer, Antony, France/Shionogi & Co. Ltd., Osaka, Japan) is the first sublingual immunotherapy (SLIT) tablet to be approved for the treatment of HDM-induced allergic rhinitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2016.1237288DOI Listing
November 2016
9 Reads

New developments in work-related asthma.

Expert Rev Clin Immunol 2017 Mar 30;13(3):271-281. Epub 2016 Sep 30.

g Unidad de Gestión Clínica Alergología , Hospital Virgen Macarena , Sevilla , Spain.

Introduction: Work-related asthma includes two subtypes: occupational asthma or asthma caused by specific agents (sensitizers or irritants) in the workplace, and work-exacerbated asthma or pre-existing asthma worsened by workplace exposures. Areas covered: This review provides an update on the definitions and the clinical features of the different work-related asthma subtypes as well as new insights into their etiology and the pathophysiological mechanisms involved. The diagnosis of work-related asthma should be made on objective basis using a constellation of clinical, physiologic and allergologic tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1239529DOI Listing
March 2017
27 Reads

Allergic bronchopulmonary aspergillosis in asthma.

Authors:
Alan P Knutsen

Expert Rev Clin Immunol 2017 01 22;13(1):11-14. Epub 2016 Sep 22.

a Division of Allergy & Immunology, Department of Pediatrics , Saint Louis University , St. Louis , MO , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2017.1232620DOI Listing
January 2017
1 Read

Biologics targeting IL-5, IL-4 or IL-13 for the treatment of asthma - an update.

Authors:
Garry M Walsh

Expert Rev Clin Immunol 2017 Feb 2;13(2):143-149. Epub 2016 Aug 2.

a School of Medicine and Dentistry , University of Aberdeen , Scotland , UK.

Introduction: The development of monoclonal antibody-based biologics targeted at inhibition of the Th2 cytokines IL-4, IL-5 and IL-13 represent potentially effective treatments for patients with the glucocorticoid refractory eosinophilic asthma phenotype. Areas covered: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease. It is becoming apparent that significant clinical effects with anti-cytokine-based biologic therapies are more likely in carefully selected patient populations that take asthma phenotypes into account. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2016.1216316DOI Listing
February 2017
6 Reads

The role of interleukin 5 in asthma.

Expert Rev Clin Immunol 2016 09 25;12(9):903-5. Epub 2016 Jul 25.

b Allergy & Respiratory Diseases, DIMI Dept of Internal Medicine , University of Genoa, IRCCS AOU San Martino-IST , Genoa , Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/1744666X.2016.1208564DOI Listing
September 2016
10 Reads