147,812 results match your criteria Allergy Asthma & Immunology Research [Journal]


Severe Eosinophilic Allergic Asthma Responsive to Mepolizumab After Failure of 2 Consecutive Biologics.

J Investig Allergol Clin Immunol 2019 Feb;29(1):79-81

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0340DOI Listing
February 2019

Wheat Anaphylaxis due to Skin Contact in an Exclusively Breastfed 2.5-Month-Old Infant.

J Investig Allergol Clin Immunol 2019 Feb;29(1):62-64

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.18176/jiaci.0332DOI Listing
February 2019

Factors Affecting the Food Allergy Profile of Children From Schools in Hortaleza District, Madrid, Spain.

J Investig Allergol Clin Immunol 2019 Feb;29(1):60-62

Unidad de Estadística, Secretaría Adjunta de Informática, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0330DOI Listing
February 2019

Dilemmas and New Paradigms in Asthma Management.

J Investig Allergol Clin Immunol 2019 Feb;29(1):15-23

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ) and CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

Asthma is one of the most common inflammatory diseases in the world. The main goal of treatment is to achieve optimal control. Although every patient is different, clinical practice guidelines can help physicians to manage the disease. Read More

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http://dx.doi.org/10.18176/jiaci.0345DOI Listing
February 2019

Mold Sensitization in Asthmatic and Non-asthmatic Subjects Diagnosed with Extract-Based Versus Component-Based Allergens.

Adv Exp Med Biol 2019 Feb 20. Epub 2019 Feb 20.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.

Asthmatic patients are suspected of having a higher risk of mold sensitization. Thus, precise diagnosis of fungal sensitization is important. Mold allergen extracts are difficult to standardize, but component-resolved allergy diagnosis may be an alternative to replace extract-based tests. Read More

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http://dx.doi.org/10.1007/5584_2019_342DOI Listing
February 2019

Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial.

Ann Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1620, New York, NY, 10029-6574, USA.

Inhaled mometasone was shown to improve pain scores and decrease soluble vascular cell adhesion molecule (sVCAM) concentration in a randomized controlled trial of nonasthmatic patients with sickle cell disease. We sought to explore potential changes in systemic inflammation as a mechanism underlying this effect. Serum samples from 41 trial participants (15 placebo- and 26 mometasone-treated) were analyzed using a 92 inflammatory marker panel at baseline and after 8 weeks of mometasone therapy. Read More

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http://dx.doi.org/10.1007/s00277-019-03635-9DOI Listing
February 2019

The effect of passive smoking on exhaled nitric oxide in asthmatic children.

Nitric Oxide 2019 Feb 16. Epub 2019 Feb 16.

Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Poland.

To date, some studies suggest that passive smoking (PS) may be an important determinant of FeNO levels in children but sill there is a need of investigations using objective methods of PS exposure. The aim of our study was to examine the effect of PS, measured by urine cotinine levels, on FeNO and lung function (FEV1) in allergic and non-allergic asthmatic children. METHODS: It was a prospective, non-interventional study. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.012DOI Listing
February 2019

Asthma with multiple allergic comorbidities is associated with complete response to omalizumab.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

AP-HP, Groupe hospitalier Trousseau, La Roche Guyon, Centre de l'Asthme et des Allergies, Paris, France.

Patients with severe asthma constitute a heterogeneous population, and different phenotypes have been identified both in adults and children. Severe asthma affects 4.5% of children with current asthma. Read More

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http://dx.doi.org/10.1111/cea.13373DOI Listing
February 2019

Clinical Efficacy, Safety and Tolerability of a New Subcutaneous Immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the Treatment of Patients With Primary Immunodeficiencies.

Front Immunol 2019 4;10:40. Epub 2019 Feb 4.

Department of Clinical Immunology and Allergology, St Anne's University Hospital in Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Subcutaneously administered immunoglobulin (SCIG) is increasingly used to treat patients with primary immunodeficiencies (PIDs). Octanorm (marketed as cutaquig® in USA and Canada) is a new 16.5% solution of human SCIG, manufactured by a process based on that of the intravenous preparation (IVIG) octagam®. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369354PMC
February 2019

Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity.

Adv Rheumatol 2019 Feb 18;59(1). Epub 2019 Feb 18.

Molecular immunology research center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial arthritis. The genetic-environmental factors seem to be involved in the pathogenesis of the disease and the disease debilitates patients during the most productive stages of their lives. The aim of this study was to examine the relationships between two environmental factors, diet and air pollution with disease activity and functional impairment in AS. Read More

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http://dx.doi.org/10.1186/s42358-019-0051-2DOI Listing
February 2019
1 Read

AAAAI/ACAAI subcutaneous immunotherapy (SCIT) surveillance study (2013-2017): fatalities, infections, delayed reactions and use of epinephrine auto-injectors.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Immunology, Allergy, and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and Bernstein Clinical Research Center, Cincinnati, Ohio.

Background: SCIT is highly effective but safety risks exist.

Objective: The aims of this study were to: 1) identify clinical practices that could influence fatal and non-fatal systemic allergic reactions (SRs) to SCIT; and 2) identify SCIT-associated infections.

Methods: From 2008-2016, 27-51% of AAAAI/ACAAI members completed an annual survey of SCIT-related SRs of varying severity. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.058DOI Listing
February 2019

Do youth ask asthma providers the questions they want to ask?

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Cecil G. Sheps, Center for Health Services Research, University of North Carolina at Chapel Hill.

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193016
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http://dx.doi.org/10.1016/j.jaip.2019.02.005DOI Listing
February 2019
1 Read

Point of care ultrasonography in the allergy and immunology clinic.

Ann Allergy Asthma Immunol 2019 Feb 15. Epub 2019 Feb 15.

Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.02.010DOI Listing
February 2019

House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation.

Microb Pathog 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology, Immunology and Molecular Genetics, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. Electronic address:

Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.019DOI Listing
February 2019

Nasal IgE Production in Allergic Rhinitis: Impact of Rhinovirus Infection.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

Departments of Medicine, University of Virginia Health System, Charlottesville, VA, 22908.

Background: Rhinovirus (RV) infections exacerbate asthma in part by enhancing an allergic state and these exacerbations can be mitigated via administration of anti-IgE.

Objective: We investigated the presence of local IgE production in the nose of allergic and non-allergic subjects and assessed whether this was enhanced by RV.

Methods: Local production of specific IgE was determined by comparing ratios of specific to total IgE concentrations between nasal and serum samples. Read More

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http://dx.doi.org/10.1111/cea.13372DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Two vs four puffs of albuterol: does dose change bronchodilator response?

J Asthma Allergy 2019 31;12:59-65. Epub 2019 Jan 31.

Department of Pediatric Pulmonary Medicine, Connecticut Children's Medical Center, Hartford, CT, USA,

Background: Reversible obstruction on spirometry may be used to diagnose asthma. As per 2005 American Thoracic Society (ATS) guidelines, our pulmonary center began using 360 µg (four puffs) of albuterol rather than 180 µg (two puffs) to determine reversibility on spirometry starting in 2009.

Hypothesis: We hypothesized that fewer patients would respond to two puffs of albuterol than four puffs during spirometric testing. Read More

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http://dx.doi.org/10.2147/JAA.S151531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362946PMC
January 2019

Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

J Asthma Allergy 2019 25;12:43-58. Epub 2019 Jan 25.

Respiratory, US Medical Affairs, GSK, La Jolla, CA, USA.

Purpose: Patients with severe asthma are eligible for asthma-specific biologics as add-on therapies, such as mepolizumab and omalizumab, when optimized controller therapies are unable to control their symptoms. However, few real-world data are available to describe the characteristics and associated economic burden of patients considered to be candidates for mepolizumab or omalizumab therapy.

Methods: This retrospective cohort study investigated patients with asthma (≥12 years of age) identified at the time of first mepolizumab or omalizumab administration (index date) in the MarketScan Commercial Database. Read More

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https://www.dovepress.com/real-world-characteristics-and-dis
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http://dx.doi.org/10.2147/JAA.S189676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354698PMC
January 2019
3 Reads

Association of genetic variants with level of asthma control in the Arab population.

J Asthma Allergy 2019 23;12:35-42. Epub 2019 Jan 23.

Hematology Laboratory, Department of Medical Laboratory, King Abdullah University Hospital, Irbid, Jordan.

Background: Rates of asthma in Jordan have been doubled in the past decade, but this increased prevalence was not met with improved asthma control protocols. The aim of the present study was to assess whether there was any significant association between the level of asthma control and certain single-nucleotide polymorphisms (SNPs) in five genes: (; rs1042713 and rs1042714), (; rs1876828, rs242939, and rs242941), (; rs2236647), (, rs1154400), and (; rs2781659). These SNPs were selected based on their involvement in enzymes and receptors that are related to asthma pathways and subsequent response to medication and based on a high degree of linkage disequilibrium. Read More

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http://dx.doi.org/10.2147/JAA.S186252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350652PMC
January 2019

Daily patient-reported health status assessment improvements with benralizumab for patients with severe, uncontrolled eosinophilic asthma.

J Asthma Allergy 2019 23;12:21-33. Epub 2019 Jan 23.

AstraZeneca, Gaithersburg, MD, USA,

Background: Patients with severe, uncontrolled asthma experience debilitating symptoms that result in meaningful reductions to health-related quality of life. Benralizumab is an interleukin-5 receptor alpha-directed cytolytic monoclonal antibody that reduces exacerbations and improves asthma symptoms for patients with severe, uncontrolled eosinophilic asthma.

Objective: The objective of this study was to evaluate improvements in daily asthma-related health status outcomes following treatment with benralizumab. Read More

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http://dx.doi.org/10.2147/JAA.S190221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350639PMC
January 2019

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

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http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

Trends in Asthma Control, Treatment, Healthcare Utilization and Expenditures among Children in the United States by Place of Residence: 2003-2014.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

Novartis Pharmaceuticals Corporation, East Hanover, NJ.

Background: Examining national trends in asthma treatment and control is essential to inform treatment and public health initiatives.

Objective: Explore national trends in asthma control and treatment over time among children and those residing in poor-urban areas.

Methods: This was an analysis of trends from 2003-2014 among children (aged 1-17) in the Medical Expenditure Panel Survey (MEPS). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.055DOI Listing
February 2019
1 Read

Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention of hereditary angioedema attacks.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

CSL Behring LLC, King of Prussia, PA, USA.

Background: For the prevention of attacks of hereditary angioedema (HAE), the efficacy and safety of subcutaneous human C1-esterase inhibitor (C1-INH[SC]; HAEGARDA, CSL Behring) was established in the 16-week COMPACT trial.

Objective: To assess the long-term safety, occurrence of angioedema attacks, and use of rescue medication with C1-INH(SC).

Methods: Open-label, randomised, parallel-arm extension of COMPACT across 11 countries. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.054DOI Listing
February 2019
1 Read

Drug Hypersensitivity Reactions in the Americas: Similarities and Differences.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Tan Tock Seng Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.anai.2019.02.007DOI Listing
February 2019
1 Read

African American Ancestry Contribution to Asthma and Atopic Dermatitis.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

University of Colorado Denver, Aurora CO. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10811206193010
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http://dx.doi.org/10.1016/j.anai.2019.02.009DOI Listing
February 2019
2 Reads

Pro-Con Debate: Component resolved diagnostic testing is not useful for making food allergy diagnoses.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Associate Professor of Pediatrics; Director, Food Challenge and Research Unit, Children's Hospital of Colorado, Section of Allergy and Immunology, University of Colorado School of Medicine. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.02.005DOI Listing
February 2019
1 Read

Con: OIT is safe/better than food avoidance.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Pediatric Allergy Unit, University Hospitals of Geneva and University of Geneva, Rue Willy Donzé 6, 1205 Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.02.006DOI Listing
February 2019
1 Read

Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Erasmus MC University Medical Center, Department of Pediatrics, division of Respiratory Medicine and Allergology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.anai.2019.02.004DOI Listing
February 2019
1 Read

From the pages of AllergyWatch May 2019.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Department: Medicine - Med/Pulmonary and Critical Care Medicine, Allergy and Immunology3, 00 Pasteur Dr Rm S087, Stanford, CA.

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http://dx.doi.org/10.1016/j.anai.2019.02.008DOI Listing
February 2019
1 Read

Academic achievement of adolescents with asthma or atopic disease.

Clin Exp Allergy 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Over a fifth of children and adolescents suffer with asthma or atopic disease. It is unclear whether asthma impacts academic performance in children and adolescents, and little is known about the association of eczema, food allergy or hay fever and academic performance.

Objective: To examine whether asthma, eczema, food allergy or hay fever impacts on adolescent academic performance and to assess the role of unmeasured confounding. Read More

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http://dx.doi.org/10.1111/cea.13371DOI Listing
February 2019
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Microarray Immunodiagnostics for Aeroallergens.

Curr Allergy Asthma Rep 2019 Feb 15;19(1):10. Epub 2019 Feb 15.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.

Purpose Of Review: The impact of new technologies, especially multiplexed molecular allergy diagnostics based on allergen arrays, on the management of complex patients with respiratory allergies has been important.

Recent Findings: Currently, the detailed characteristics of the IgE profile of the patient, such as sensitization to genuine or cross-reacting components or the sensitization to potentially harmful allergens, allow an allergist to tailor treatment in the context of precision medicine rules. A number of relevant articles have been published in recent years on this topic, and, in this review, the new added values of allergen array-based diagnostics are reported. Read More

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http://dx.doi.org/10.1007/s11882-019-0832-zDOI Listing
February 2019
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Allergen Immunotherapy for IgE-Mediated Food Allergy: there is a measure in everything to a proper proportion of therapy.

Pediatr Allergy Immunol 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Allergology Unit, Department of Pediatric Medicine, Bambino Gesù Children's research Hospital (IRCCS), Rome, Holy See, Italy.

IgE-mediated food allergy (FA) is a potentially life-threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (e. Read More

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http://doi.wiley.com/10.1111/pai.13042
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http://dx.doi.org/10.1111/pai.13042DOI Listing
February 2019
4 Reads

SO, AT WHAT AGE CAN ASTHMA BE DIAGNOSED?

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):105-106

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; and IMIB Bio-health Research Institute, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.01.001DOI Listing
January 2019
1 Read

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review.

Medicina (Kaunas) 2019 Feb 14;55(2). Epub 2019 Feb 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. Read More

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http://dx.doi.org/10.3390/medicina55020050DOI Listing
February 2019
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Does angioedema influence the quality of life in chronic spontaneous urticaria patients?

Ann Allergy Asthma Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland; Department of Internal Diseases and Allergology, Institute of Medicine, University of Opole, Opole, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.01.023DOI Listing
February 2019

Trends in hospitalizations related to anaphylaxis, angioedema and urticaria in the United States.

Ann Allergy Asthma Immunol 2019 Feb 12. Epub 2019 Feb 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Penn State College of Medicine, Hershey, PA.

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http://dx.doi.org/10.1016/j.anai.2019.02.003DOI Listing
February 2019
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Aleurites moluccanus and its main active constituent, the flavonoid 2″-O-rhamnosylswertisin, in experimental model of rheumatoid arthritis.

J Ethnopharmacol 2019 Feb 12;235:248-254. Epub 2019 Feb 12.

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil; Pharmacy Course, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Santa Catarina, Brazil.

Ethnopharmmacological Relevance: Aleurites moluccana is used in folk medicine to treat pain, fever, asthma, hepatitis, gastric ulcer and inflammatory process in general, and the nut oil had been topically applied to treat arthritis and other joint pain, however the seeds are classified as toxic for oral use.

Aim: Faced with the need for new alternative to treat the symptoms and modify rheumatoid arthritis (RA) the aim of this work was to evaluate the effects of A. moluccanus' leaves dried extract in rats and mice submitted to complete Freund adjuvant (CFA)-induced RA. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.014DOI Listing
February 2019
1 Read

Interleukin-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation.

J Allergy Clin Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Immunology, University Hospital Zurich, Gloriastrasse 23, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Ramistrasse 71, 8006 Zurich, Switzerland. Electronic address:

Background: Type 2 immunity serves to resist parasitic helminths, venoms and toxins, but the role and regulation of neutrophils during type 2 immune responses is controversial. Helminth models suggested a contribution of neutrophils to type 2 immunity, whereas neutrophils are associated with increased disease severity during type 2 inflammatory disorders such as asthma.

Objective: To evaluate the impact of the prototypic type 2 cytokines interleukin-4 (IL-4) and IL-13 on human neutrophils. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.042DOI Listing
February 2019
1 Read

Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey.

Am J Infect Control 2019 Feb 11. Epub 2019 Feb 11.

School of Nursing and Midwifery, Deakin University, Geelong, Victoria, Australia; Centre for Quality and Patient Safety Research-Monash Health Partnership, School of Nursing and Midwifery, Deakin University, Burwood, Victoria, Australia. Electronic address:

Background: Health service hand hygiene programs have seen widespread use of chlorhexidine solutions. Reports of both immediate and delayed hypersensitivity to chlorhexidine are increasing among health care workers. This study examined the prevalence of self-reported symptoms of sensitivity to chlorhexidine solutions among health care workers. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.01.006DOI Listing
February 2019
1 Read

Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma.

Allergol Immunopathol (Madr) 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Microbiology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34320, Turkey. Electronic address:

Introduction And Objectives: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.009DOI Listing
February 2019
1 Read

Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.

Respir Res 2019 Feb 14;20(1):33. Epub 2019 Feb 14.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
Publisher Site
http://dx.doi.org/10.1186/s12931-019-0996-zDOI Listing
February 2019
3 Reads

The Role of Probiotics in Preventing Allergic Disease.

Children (Basel) 2019 Feb 5;6(2). Epub 2019 Feb 5.

Department of Pediatrics, Section of Immunology, Allergy, Rheumatology, and Retrovirology, Texas Children's Hospital, Houston, TX 77030, USA.

The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. Read More

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http://dx.doi.org/10.3390/children6020024DOI Listing
February 2019
1 Read

Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions.

Med Sci (Basel) 2019 Feb 5;7(2). Epub 2019 Feb 5.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata 573-1010, Japan.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infiltration of eosinophils into the inflamed site, the paranasal sinus. Although eosinophils are known to contribute to the development of hyposmia and CRSwNP pathology, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.3390/medsci7020022DOI Listing
February 2019
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TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation.

Int Arch Allergy Immunol 2019 Feb 14:1-10. Epub 2019 Feb 14.

Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood.

Objectives: The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation. Read More

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http://dx.doi.org/10.1159/000493583DOI Listing
February 2019

The role of early life food sensitization in adolescent lung function: Results from two birth cohort studies.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia;; Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Background: It is unclear whether early life food sensitization (as opposed to aeroallergen sensitization) is associated with subsequent poor lung function.

Objectives: We investigated the associations between food sensitization in the first two years of life and lung function at 12 to 18 years and whether these observed associations are mediated through aeroallergen sensitization or asthma.

Methods: We used data from a high-risk cohort (MACS) and a population-based (LISAplus) cohort. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.050DOI Listing
February 2019

Vitamin D status modifies the response to indoor particulate matter in obese urban children with asthma.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Department of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Background: Indoor fine particulate air pollution (PM) is linked to asthma morbidity; however, whether vitamin D status influences individual susceptibility to airborne exposures is unclear.

Objective: We aimed to determine if vitamin D modifies effects of indoor PM upon asthma symptoms in urban children.

Methods: 120 children aged 5-12 years with physician-diagnosed asthma were evaluated at baseline and every 3 months for 9 months. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.051DOI Listing
February 2019

Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses.

J Allergy Clin Immunol 2019 Feb 11. Epub 2019 Feb 11.

Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE-idiotypes. Whilst tissue IgE concentrations can be in the range of several thousand kU/L, the regulatory mechanisms by which IgE-mediated inflammation is controlled in the nasal polyps is not well understood.

Objective: We sought to determine whether locally induced IgG antibodies in the nasal polyps can inhibit IgE-mediated pro-allergic response. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.001DOI Listing
February 2019
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DNA methylation and allergic sensitizations, a genome-scale longitudinal study during adolescence.

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Sachs' Children's Hospital, Stockholm, Sweden.

Background: The presence of allergic sensitization has a major influence on the development and course of common childhood conditions such as asthma and rhinitis. The etiology of allergic sensitization is poorly understood and its underlying biological mechanisms are not well established. Several studies showed that DNA methylation (DNAm) at some CpGs is associated with allergic sensitization. Read More

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http://dx.doi.org/10.1111/all.13746DOI Listing
February 2019
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Type 3 ILCs in Lung Disease.

Front Immunol 2019 29;10:92. Epub 2019 Jan 29.

Africa Health Research Institute, Durban, South Africa.

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361816PMC
January 2019

Epigenetic findings in periodontitis in UK twins: a cross-sectional study.

Clin Epigenetics 2019 Feb 13;11(1):27. Epub 2019 Feb 13.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Background: Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism for mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease. Read More

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http://dx.doi.org/10.1186/s13148-019-0614-4DOI Listing
February 2019
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