156,319 results match your criteria Allergy Asthma & Immunology Research [Journal]


Long-Term, Open-Label Extension Study of the Efficacy and Safety of Epicutaneous Immunotherapy for Peanut Allergy in Children: PEOPLE 3-Year Results.

J Allergy Clin Immunol 2020 Jul 10. Epub 2020 Jul 10.

DBV Technologies, Montrouge, France; Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: We previously reported the safety and efficacy of epicutaneous immunotherapy (EPIT™) for peanut allergy (250 μg, daily epicutaneous peanut protein; DBV712 250μg) in a 12-month randomized controlled study (PEPITES) of peanut-allergic children aged 4-11 years.

Objective: To assess interim safety and efficacy of an additional 2 years of EPIT from the ongoing (5-year treatment) open-label extension PEOPLE study.

Methods: Subjects who completed PEPITES were offered enrollment in PEOPLE. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.028DOI Listing

Asthma prevalence in patients with SARS-CoV-2 infection detected by RT-PCR not requiring hospitalization.

Respir Med 2020 Jul 4;171:106084. Epub 2020 Jul 4.

Section of Microbiology, Hospital General Universitario de Elche, Alicante, Spain.

Introduction: The prevalence of asthma in patients hospitalized with SARS-CoV-2 has been studied and varies widely in the different series. However, the prevalence in SARS-infected patients not requiring hospitalization is not known. The objective of this study was to analyze the presence of asthma in a consecutive series of patients who tested positive in the RT-PCR assay for SARS-CoV-2 and did not require hospital admission. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.106084DOI Listing

Self-injectable epinephrine: doctors' attitude and patients' adherence in real-life.

Curr Opin Allergy Clin Immunol 2020 Jul 9. Epub 2020 Jul 9.

Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA.

Purpose Of Review: Epinephrine is the only life-saving treatment of anaphylaxis. Prescription and administration rates of self-injectable epinephrine are generally low. It is unclear whether this is because of availability, low prescription rates, fear of using epinephrine, or a combination of these issues. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000664DOI Listing

Economic considerations on the usage of biologics in the allergy clinic.

Allergy 2020 Jul 13. Epub 2020 Jul 13.

Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada.

The advent of biologic therapies has transformed care for severe atopic disorders but their high cost poses new challenges with regards to long-term sustainability and fair allocation of resources. This article covers the basic concepts of cost-utility analyses and reviews the available literature on cost-utility of biologic drugs in atopic disorders. When used within their limits as part of a multi-dimensional assessment, economic analyses can be extremely useful to guide decision-making and prioritization of care. Read More

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http://dx.doi.org/10.1111/all.14494DOI Listing

Pet-Keeping in Relation to Asthma, Rhinitis, and Eczema Symptoms Among Adolescents in Kuwait: A Cross-Sectional Study.

Front Pediatr 2020 23;8:331. Epub 2020 Jun 23.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Findings on the associations between household pet-keeping and allergic diseases, including asthma, rhinitis, and eczema, have been contradictory, with investigations reporting positive, negative, and null associations. This study sought to estimate the prevalence of pet-keeping among families in Kuwait and to assess the associations between pet-keeping and symptoms of allergic diseases among adolescents. Schoolchildren aged 11-14 years ( = 3,864) were enrolled in this cross-sectional study. Read More

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http://dx.doi.org/10.3389/fped.2020.00331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324793PMC

The Emerging Role of Eosinophils as Multifunctional Leukocytes in Health and Disease.

Immune Netw 2020 Jun 23;20(3):e24. Epub 2020 Jun 23.

Department of Microbiology, College of Medicine, Gachon University, Incheon 21999, Korea.

Eosinophils are terminally differentiated cytotoxic effector cells that have a role in parasitic infections and allergy by releasing their granule-derived cytotoxic proteins. However, an increasing number of recent observations indicate that eosinophils are not only associated with the pathogenesis of a wide range of diseases, but also contribute to the maintenance of homeostatic responses in previously underappreciated diverse tissues, such as the gastrointestinal (GI) tract and adipose tissue. In this review, we describe biological characteristics of eosinophils, as their developmental properties, permissive proliferation and survival, degranulation activity, and migration properties enable them to distribute to both homeostatic and inflamed tissues. Read More

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http://dx.doi.org/10.4110/in.2020.20.e24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327148PMC

Epidemiological aspects of allergic conjunctivitis.

Allergol Int 2020 Jul 9. Epub 2020 Jul 9.

Division of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, Tottori, Japan.

The prevalence of ocular allergies has been increasing worldwide for the past several decades. The geographical distribution and hot spots of rhinoconjunctivitis have been documented in a global survey by the International Study of Asthma and Allergies in Childhood (ISAAC). ISAAC indicated that Africa, Latin America, and Japan were notable for their high prevalence of rhinoconjunctivitis. Read More

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http://dx.doi.org/10.1016/j.alit.2020.06.004DOI Listing

Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management.

Authors:
Paul J Maglione

Immunol Allergy Clin North Am 2020 Aug 9;40(3):437-459. Epub 2020 Jun 9.

Pulmonary Center, Boston University School of Medicine, 72 East Concord Street, R304, Boston, MA 02118, USA. Electronic address:

Chronic lung disease is a complication of primary antibody deficiency (PAD) associated with significant morbidity and mortality. Manifestations of lung disease in PAD are numerous. Thoughtful application of diagnostic approaches is imperative to accurately identify the form of disease. Read More

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http://dx.doi.org/10.1016/j.iac.2020.03.003DOI Listing

Vaccines in Patients with Primary Immune Deficiency.

Immunol Allergy Clin North Am 2020 Aug;40(3):421-435

Northeast Allergy, Asthma & Immunology, 79 Erdman Way, Suite 101, Leominster, MA 01453, USA. Electronic address:

Evaluation of antibodies produced after immunization is central to immune deficiency diagnosis. This includes assessment of responses to routine immunizations as well as to vaccines administered specifically for diagnosis. Here, we present the basic concepts of the humoral immune response and their relevance for vaccine composition and diagnosis of immune deficiency. Read More

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http://dx.doi.org/10.1016/j.iac.2020.03.004DOI Listing

IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.

Pediatr Int 2020 Jul 12. Epub 2020 Jul 12.

Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Background: Interleukin-17A (IL-17A) and IL-17F are involved with pathogenesis of asthma and allergy. Interleukin-17 receptor A (IL-17RA), encoded by the IL17RA gene, is a common receptor for IL-17A and IL-17F. The aim of the present study was to evaluate the association of IL17RA gene variations with asthma, allergy and lung function at school age in children prospectively followed-up after hospitalization for bronchiolitis in early infancy. Read More

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http://dx.doi.org/10.1111/ped.14387DOI Listing

The neighbourhood natural environment is associated with asthma in children: a birth cohort study.

Allergy 2020 Jul 12. Epub 2020 Jul 12.

EPIUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Background: A lower exposure to the natural environment has been hypothesized to adversely affect the human microbiome and its immunomodulatory capacity. However,the underlying effects of this hypothesis are stillnot understood. We aimed to evaluate the effect of early-life exposure to greenness and species richness on the development of allergic diseases and asthma in children. Read More

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http://dx.doi.org/10.1111/all.14493DOI Listing

Otitis Media and Inborn Errors of Immunity.

Curr Allergy Asthma Rep 2020 Jul 11;20(10):59. Epub 2020 Jul 11.

Clinical Immunology, Reference Center for Rare Diseases, Faculdade de Medicina, Centro Universitario Saude ABC, Avenida Lauro Gomes, 2000, Santo Andre, SP, 09060-870, Brazil.

Purpose Of Review: The aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.

Recent Findings: Otitis media is a very common infection in general population. The concept of otitis-prone children established a certain frequency of the infections in order to look for conditions leading to them. Read More

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http://dx.doi.org/10.1007/s11882-020-00957-xDOI Listing

OCCUPATIONAL RHINITIS.

J Allergy Clin Immunol Pract 2020 Jul 9. Epub 2020 Jul 9.

Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

There is convincing evidence that tight relationships between the upper and lower airways also apply to the workplace context. The majority of patients with occupational asthma (OA) also suffer from ocupational rhinitis (OR), although OR is 2 to 3 times more common than occupational asthma (OA). OR most often precedes the development of OA, especially when high-molecular-weight protein agents are involved, and longitudinal cohort studies have confirmed that OR is associated with an increased risk for the development of OA. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.047DOI Listing

Chronic stress and asthma in adolescents.

Ann Allergy Asthma Immunol 2020 Jul 9. Epub 2020 Jul 9.

Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital. Electronic address:

Objective: To first review and critically discuss published evidence on psychosocial stressors, stress, and asthma in adolescents, and then discuss potential future directions in this field.

Data Sources: National Library of Medicine (Pubmed).

Study Selections: A literature search was conducted for human studies on stressors or stress and asthma between 2000 and 2020. Read More

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http://dx.doi.org/10.1016/j.anai.2020.07.001DOI Listing

Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.

Ann Emerg Med 2020 Jul 8. Epub 2020 Jul 8.

TerSera Therapeutics, Deerfield, IL.

Study Objective: Acute urticaria is a frequent presentation in emergency departments (EDs), urgent care centers, and other clinical arenas. Treatment options are limited if diphenhydramine is the only intravenous antihistamine offered because of its short duration of action and well-known adverse effects. We evaluate cetirizine injection, the first second-generation injectable antihistamine, for acute urticaria in this multicenter, randomized, noninferiority, phase 3 clinical trial. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2020.05.025DOI Listing

Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.

Lancet Respir Med 2020 Jul 9. Epub 2020 Jul 9.

Novartis Pharmaceuticals, East Hanover, NJ, USA.

Background: Patients with asthma who are inadequately controlled on inhaled corticosteroid-long-acting β-adrenoceptor agonist (ICS-LABA) combinations might benefit from the addition of a long-acting muscarinic receptor antagonist. The aim of the IRIDIUM study was to assess the efficacy and safety of a once-daily, single-inhaler combination of mometasone furoate, indacaterol acetate, and glycopyrronium bromide (MF-IND-GLY) versus ICS-LABA in patients with inadequately controlled asthma.

Methods: In this 52-week, double-blind, double-dummy, parallel-group, active-controlled phase 3 study, patients were recruited from 415 sites across 41 countries. Read More

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http://dx.doi.org/10.1016/S2213-2600(20)30190-9DOI Listing

Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study.

Environ Health Prev Med 2020 Jul 11;25(1):28. Epub 2020 Jul 11.

Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.

Background: Sick building syndrome (SBS) refers to the combination of symptoms experienced by occupants of specific building characteristics. This study investigated the associations of children's lifestyle behaviors, allergies, home, and school environment with SBS symptoms.

Methods: A total of 4408 elementary school children living in Sapporo City, Japan participated in this study. Read More

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http://dx.doi.org/10.1186/s12199-020-00869-2DOI Listing

Oscillometry for Acute Asthma in the Pediatric Emergency Department: A Feasibility Study.

Ann Allergy Asthma Immunol 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Pulmonary and Sleep Medicine, Children's Hospital Colorado, University of Colorado School of Medicine.

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http://dx.doi.org/10.1016/j.anai.2020.07.002DOI Listing

Veganism and paediatric food allergy: two increasingly prevalent dietary issues that are challenging when co-occurring.

BMC Pediatr 2020 Jul 10;20(1):341. Epub 2020 Jul 10.

Paediatric Primary Health Care Clinics of Västra Götaland, Västra Götaland, Sweden.

Vegan diets - defined as the exclusion of all foods of animal origin from the diet- are becoming popular. In recent years, the prevalence of food allergy has also increased, and disproportionately affects children. When vegan diets and food allergy co-occur, this combination can be challenging and pose risks of nutritional deficiencies, particularly during childhood. Read More

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http://dx.doi.org/10.1186/s12887-020-02236-0DOI Listing

Allergic Anaphylactic Risk in Farming Activities: A Systematic Review.

Int J Environ Res Public Health 2020 Jul 8;17(14). Epub 2020 Jul 8.

Department of Experimental and Clinical Medicine, University of Florence, 50139 Florence, Italy.

Allergic disorders in the agriculture sector are very common among farm workers, causing many injuries and occupational diseases every year. Agricultural employees are exposed to multiple conditions and various allergenic substances, which could be related to onset of anaphylactic reactions. This systematic review highlights the main clinical manifestation, the allergens that are mostly involved and the main activities that are usually involved. Read More

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http://dx.doi.org/10.3390/ijerph17144921DOI Listing

A counseling video with pre- and post- testing and checklist for oral immunotherapy consent improves participant knowledge.

Ann Allergy Asthma Immunol 2020 Jul 7. Epub 2020 Jul 7.

McMaster University, Hamilton, Ontario.

Background: The use of Oral immunotherapy (OIT) for food has expanding in North America. Families are interested in this therapeutic approach however misconceptions are common and education of these families is essential prior to obtaining informed consent.

Objective: We investigated the use of a counselling video and checklist to improve parent and patient knowledge about OIT. Read More

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http://dx.doi.org/10.1016/j.anai.2020.06.044DOI Listing

Intranasal antihistamine is superior to oral H1-antihistamine as an add-on therapy to intranasal corticosteroid for treating allergic rhinitis.

Ann Allergy Asthma Immunol 2020 Jul 7. Epub 2020 Jul 7.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing 100005, China; Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China; Beijing Key Laboratory of Nasal diseases, Beijing Institute of Otolaryngology, Beijing 100005, China. Electronic address:

Background: Currently a combination of intranasal corticosteroid (INCS) plus oral H1antihistamines (OAH) or intranasal H1-antihistamines (INAH) therapy is frequently used in the treatment of allergic rhinitis (AR). The superiority of the two combined treatments needs to be further examined.

Objective: To identify the better of the two therapeutic strategies. Read More

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http://dx.doi.org/10.1016/j.anai.2020.06.038DOI Listing

Unsupervised Modeling and Genome-Wide Association Identify Novel Features of Allergic March Trajectories.

J Allergy Clin Immunol 2020 Jul 7. Epub 2020 Jul 7.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Background: The allergic march refers to the natural history of allergic conditions during infancy and childhood. However, population-level disease incidence patterns do not necessarily reflect the development of allergic disease in individuals. A better understanding of the factors that predispose to different allergic trajectories is needed. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.026DOI Listing

Human Milk Oligosaccharide profiles and allergic disease up to 18 years.

J Allergy Clin Immunol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence, University of California San Diego, La Jolla, US.

Background: Human Milk Oligosaccharides (HMO) are a diverse range of sugars secreted in breast milk that have direct and indirect effects on immunity. The profiles of HMOs produced differ between mothers.

Objective: To determine the relationship between maternal HMO profiles and offspring allergic diseases up to 18 years METHODS: Colostrum and early lactation milk samples were collected from 285 mothers enrolled in a high allergy risk birth cohort, the Melbourne Atopy Cohort Study. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.027DOI Listing

A demonstration project of Global Alliance against Chronic Respiratory Diseases: Prediction of interactions between air pollution and allergen exposure-the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach.

Chin Med J (Engl) 2020 Jul;133(13):1561-1567

University Hospital Montpellier, Montpellier 34000, France.

This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers. For decades, information available for the patients and allergologists consisted of pollen counts, which are vital but insufficient. New technology paves the way to substantial increase in amount and diversity of the data. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000916DOI Listing

Olfactory Dysfunction in Traumatic Brain Injury: the Role of Neurogenesis.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):55. Epub 2020 Jul 9.

INGENIO, IRCE, Department 2B, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036, Barcelona, Catalonia, Spain.

Purpose Of Review: Olfactory functioning disturbances are common following traumatic brain injury (TBI) having a significant impact on quality of life. A spontaneous recovery of the olfactory function over time may occur in TBI patients. Although there is no standard treatment for patients with posttraumatic olfactory loss, olfactory training (OT) has shown some promise beneficial effects. Read More

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http://dx.doi.org/10.1007/s11882-020-00949-xDOI Listing

Role of Allergy in Eustachian Tube Dysfunction.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):54. Epub 2020 Jul 9.

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, USA.

Purpose Of Review: Eustachian tube dysfunction (ETD) presents with symptoms of aural fullness and pressure, muffled hearing, tinnitus, and otalgia. When severe, it can lead to many common ear disorders such as otitis media with effusion, tympanic membrane retraction/perforation, and cholesteatoma. These diseases are prevalent in both the pediatric and adult population and significantly impact quality of life. Read More

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http://dx.doi.org/10.1007/s11882-020-00951-3DOI Listing

Localized Granulomatous with Polyangiitis (GPA): Varied Clinical Presentations and Update on Treatment.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):56. Epub 2020 Jul 9.

Division of Rheumatology, Department of Medicine, Weill Cornell Medicine, Scleroderma, Vasculitis and Myositis Center, Hospital for Special Surgery, 525 East 71st Street, 7th Floor, New York, NY, 10021, USA.

Purpose Of Review: Granulomatosis with polyangiitis is a primary systemic vasculitis commonly described with the typical triad of upper airway, lung, and kidney involvement. Upper and lower airway involvement is characteristic in patients with granulomatosis with polyangiitis and can sometimes represent the initial or in some instances the sole manifestation. The objective of this review is to summarize the various clinical manifestations of localized disease in GPA and their treatment. Read More

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http://dx.doi.org/10.1007/s11882-020-00953-1DOI Listing

Update on DNA-Double Strand Break Repair Defects in Combined Primary Immunodeficiency.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):57. Epub 2020 Jul 9.

Paediatric Immunology and Haematopoietic Stem Cell Transplantation, Great North Children's Hospital, Clinical Resource Building, Floor 4, Block 2, Newcastle upon Tyne, UK.

Purpose Of Review: The most serious DNA damage, DNA double strand breaks (DNA-dsb), leads to mutagenesis, carcinogenesis or apoptosis if left unrepaired. Non-homologous end joining (NHEJ) is the principle repair pathway employed by mammalian cells to repair DNA-dsb. Several proteins are involved in this pathway, defects in which can lead to human disease. Read More

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http://dx.doi.org/10.1007/s11882-020-00955-zDOI Listing

Scribes, EHRs, and Workflow Efficiencies in Allergy Practices.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):53. Epub 2020 Jul 9.

Department of Pediatrics, Division of Pulmonary, Sleep, Allergy and Immunology, University of Tennessee Health Science Center, Memphis, TN, USA.

Purpose Of Review: In the ever-changing healthcare system, along with new advancements in the field of allergy, the workflow for the allergist continues to evolve requiring more time spent doing non-clinical duties such as documentation and reviewing reimbursement challenges in the midst of busy clinics. The use of electronic medical records and medical scribes has emerged as tactics to aid the clinic's workflow and efficiency in the modern allergy and immunology clinic.

Recent Findings: The practicing allergist can implement various additional strategies in their office workflow to maximize and synthesize good medicine and good business. Read More

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http://dx.doi.org/10.1007/s11882-020-00950-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344040PMC

Antigen 5 Allergens of Hymenoptera Venoms and Their Role in Diagnosis and Therapy of Venom Allergy.

Curr Allergy Asthma Rep 2020 Jul 9;20(10):58. Epub 2020 Jul 9.

Experimental Dermatology and Allergy Research Group, Department of Dermatology and Allergology, Justus-Liebig-University Gießen, Giessen, Germany.

Purpose Of Review: Stings of Hymenoptera of the superfamily Vespoidea such as yellow jackets, paper wasps or stinging ants are common triggers for severe and even fatal allergic reactions. Antigen 5 allergens are potent allergens in the majority of these venoms with major importance for diagnosis and therapy. Reviewed here are the characteristics of antigen 5 allergens, their role in component-resolved diagnostics as well as current limitations of the available diagnostics for proper therapeutic decisions. Read More

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http://dx.doi.org/10.1007/s11882-020-00954-0DOI Listing

Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome.

Cells 2020 Jul 7;9(7). Epub 2020 Jul 7.

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.

Basophils are involved in manifestations of hypersensitivity, however, the current understanding of their propensity for activation and their prognostic value in cancer patients remains unclear. As in healthy and atopic individuals, basophil populations were identified in blood from ovarian cancer patients ( = 53) with diverse tumor histologies and treatment histories. Ex vivo basophil activation was measured by CD63 expression using the basophil activation test (BAT). Read More

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http://dx.doi.org/10.3390/cells9071631DOI Listing

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation.

Allergy 2020 Jul 9. Epub 2020 Jul 9.

Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Dublin, Ireland.

Background: Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79 mice harbor mutations in the gene encoding Transmembrane Protein 79 (or Mattrin), which have previously been associated with AD. As a result of the Tmem79 gene mutation, these mice have a defective skin barrier and develop spontaneous skin inflammation. Read More

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http://dx.doi.org/10.1111/all.14488DOI Listing

Management of interstitial lung diseases: A consensus statement of the Indian Chest Society (ICS) and National College of Chest Physicians (NCCP).

Lung India 2020 Jul-Aug;37(4):359-378

Department of Medicine, University of Washington, Seattle, USA.

Background: Interstitial lung disease (ILD) is a complex and heterogeneous group of acute and chronic lung diseases of several known and unknown causes. While clinical practice guidelines (CPG) for idiopathic pulmonary fibrosis (IPF) have been recently updated, CPG for ILD other than IPF are needed.

Methods: A working group of multidisciplinary clinicians familiar with clinical management of ILD (pulmonologists, radiologist, pathologist, and rheumatologist) and three epidemiologists selected by the leaderships of Indian Chest Society and National College of Chest Physicians, India, posed questions to address the clinically relevant situation. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_275_20DOI Listing

Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper.

Clin Transl Allergy 2020 6;10:29. Epub 2020 Jul 6.

Formerly Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respiratory effects such as work-related asthma and rhinitis. Read More

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http://dx.doi.org/10.1186/s13601-020-00334-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336421PMC

Prevalence and triggers of self-reported nasal hyperreactivity in adults with asthma.

World Allergy Organ J 2020 Jun 1;13(6):100132. Epub 2020 Jul 1.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Belgium.

Background: Nasal hyperreactivity (NHR) is a common feature of various rhinitis subtypes and represents a novel phenotype of rhinitis. It is being reported in two-thirds of adult rhinitis patients irrespective of the atopic status. Data on the prevalence of NHR in patients with asthma are lacking, as well as the nature of evoking triggers. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334478PMC

Comparison of individual-level and population-level risk factors for rhinoconjunctivitis, asthma, and eczema in the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three.

World Allergy Organ J 2020 Jun 2;13(6):100123. Epub 2020 Jul 2.

Population Health Research Institute, St George's University of London, London, United Kingdom.

Background: Symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema in children cluster at both the individual and population levels.

Objectives: To assess individual-level and school-level risk factors for symptoms of rhinoconjunctivitis and compare them to corresponding associations with symptoms of asthma and eczema in Phase Three of the International Study of Asthma and Allergies in Childhood.

Methods: We studied 116,863 children aged 6-7 years from 2163 schools in 59 centres and 22 countries and 224,436 adolescents aged 13-14 years from 2037 schools in 97 centres in 41 countries. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334817PMC

The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma.

Respir Res 2020 Jul 8;21(1):176. Epub 2020 Jul 8.

Department of Internal Medicine V - Pulmonology, Allergology and Critical Care Medicine, Saarland University, D-66421, Homburg, Germany.

Background: The interleukin 17 receptor E (IL-17RE) is specific for the epithelial cytokine interleukin-17C (IL-17C). Asthma exacerbations are frequently caused by viral infections. Polyinosinic:polycytidylic acid (pIC) mimics viral infections through binding to pattern recognition receptors (e. Read More

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http://dx.doi.org/10.1186/s12931-020-01434-9DOI Listing

Titanium Dioxide Nanoparticles Exaggerate Respiratory Syncytial Virus-Induced Airway Epithelial Barrier Dysfunction.

Am J Physiol Lung Cell Mol Physiol 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Pulmonology, Cleveland Clinic Children's; Cleveland Clinic Foundation, United States.

RSV is the leading cause of lower respiratory tract infections in children worldwide. While most develop a mild, self-limiting illness, some develop severe acute lower respiratory infection and persistent airway disease. Exposure to ambient particulate matter has been linked to asthma, bronchitis, and viral infection in multiple epidemiologic studies. Read More

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http://dx.doi.org/10.1152/ajplung.00104.2020DOI Listing

House dust endotoxin, asthma and allergic sensitization through childhood into adolescence.

Clin Exp Allergy 2020 Jul 8. Epub 2020 Jul 8.

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Background: House dust endotoxin may have beneficial effects on allergic sensitization and asthma in children. Evidence is scarce for adolescents and most studies so far have been cross-sectional and limited to a single exposure measurement.

Objective: We assessed associations of house dust endotoxin with asthma and allergic sensitization from birth to age 17 years longitudinally taking into account exposure early in life and at primary school age. Read More

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http://dx.doi.org/10.1111/cea.13705DOI Listing

Biofilm propensity of Staphylococcus aureus skin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort.

Allergy 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics, University of Cincinnati College of Medicine, 3230 Eden Avenue, Cincinnati, Ohio, 45267, USA.

Background: Atopic dermatitis (AD) patients are often colonized with Staphylococcus aureus and staphylococcal biofilms have been reported on adult AD skin lesions. The commensal Staphylococcus epidermidis can antagonize S. aureus, although its role in AD is unclear. Read More

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http://dx.doi.org/10.1111/all.14489DOI Listing

Update on asthma prevalence in severe COVID-19 patients.

Allergy 2020 Jul 8. Epub 2020 Jul 8.

Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany.

We carefully read the recently published research letter "Is asthma protective of COVID-19?" by Carli et al. with great interest. Important topics for asthma patients during the coronavirus disease 2019 (COVID-19) pandemic were discussed, including that until recently there was limited evidence that patients with chronic respiratory disorders are at lower risk of being infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or becoming severely ill. Read More

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http://dx.doi.org/10.1111/all.14482DOI Listing

Management of Severe Asthma During the COVID-19 Pandemic in Korea.

Allergy Asthma Immunol Res 2020 Sep;12(5):897-901

Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Research Center for Pulmonary Disorders, Jeonbuk National University Medical School, Jeonju, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.897DOI Listing
September 2020

Omalizumab Treatment in Patients With Cholinergic Urticaria: A Real-World Retrospective Study in Korea.

Allergy Asthma Immunol Res 2020 Sep;12(5):894-896

Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.

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http://dx.doi.org/10.4168/aair.2020.12.5.894DOI Listing
September 2020
3.084 Impact Factor

Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis.

Allergy Asthma Immunol Res 2020 Sep;12(5):885-893

Immunoallergology Unit, Careggi University Hospital, Florence, Italy.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by multisystemic manifestations including asthma. Mepolizumab (300 mg/4 weeks) has recently been approved for EGPA. However, real-life data are scarce and report experiences with high doses of mepolizumab intravenously administered (750 mg/4 weeks). Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.885DOI Listing
September 2020

Mitochondrial and Nuclear Mitochondrial Variants in Allergic Diseases.

Allergy Asthma Immunol Res 2020 Sep;12(5):877-884

Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

The mitochondrial genome encodes core catalytic peptides that affect major metabolic processes within a cell. Here, we investigated the association between mitochondrial DNA (mtDNA) variants and allergic diseases, including atopic dermatitis (AD) and asthma, alongside heteroplasmy within the mtDNA in subjects with allergic sensitization. We collected genotype data from 973 subjects with allergic sensitization, consisting of 632 children with AD, 498 children with asthma, and 481 healthy controls by extracting DNA from their blood samples. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.877DOI Listing
September 2020

MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.

Allergy Asthma Immunol Res 2020 Sep;12(5):859-876

NHC Key Laboratory of Antibody Technique, Nanjing Medical University, Nanjing, Jiangsu, China.

Purpose: CD4⁺T cells are essential in the pathogenesis of allergic asthma. We have previously demonstrated that microRNA-1165-3p (miR-1165-3p) was significantly reduced in T-helper type (Th) 2 cells and that miR-1165-3p was a surrogate marker for atopic asthma. Little is known about the mechanisms of miR-1165-3p in the regulation of Th2-dominated allergic inflammation. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.859DOI Listing
September 2020

Effect of Immunotherapy on Upper and Lower Airway Eosinophilic Inflammatory Response to Nasal Allergen Challenge.

Allergy Asthma Immunol Res 2020 Sep;12(5):844-858

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Purpose: It remains unknown whether allergen-specific immunotherapy (AIT) could attenuate airway inflammatory response triggered by allergen exposure.

Methods: We performed () nasal provocation tests (NPTs) in allergic rhinitis (AR) and/or asthma patients without AIT (non-AIT), or at 16, 52, 104, or 156 weeks after AIT. Rhinitis and asthma visual analog scale (VAS; VAS of nasal symptoms [VAS-NS], VAS of asthma symptoms), the rhinoconjunctivitis quality of life questionnaire (RQLQ), nasal lavage, sputum induction, fractional exhaled nitric oxide (FeNO), nasal airway resistance, pulmonary function, and airway hyperresponsiveness were performed before and after NPT. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.844DOI Listing
September 2020

Application of Impulse Oscillometry in Adult Asthmatic Patients With Preserved Lung Function.

Allergy Asthma Immunol Res 2020 Sep;12(5):832-843

Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

Purpose: It is difficult to assess airway obstruction using spirometry in adult asthmatic patients with preserved lung function. Impulse oscillometry (IOS) can detect not only airway resistance but also reactance. Therefore, IOS may be useful in assessing pulmonary function in such patients. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.832DOI Listing
September 2020

Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.

Allergy Asthma Immunol Res 2020 Sep;12(5):821-831

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Purpose: Chronic corticosteroid (CS) use is a risk factor for long-term mortality in asthmatic patients, and the presence of coexisting chronic obstructive pulmonary disease (COPD) is associated with a severe presentation and poor prognosis. However, the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma has not been well elucidated. This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.821DOI Listing
September 2020