156,124 results match your criteria Allergy Asthma & Clinical Immunology [Journal]


From the Pages of Allergy Watch (Sept-20).

Ann Allergy Asthma Immunol 2020 Jun 29. Epub 2020 Jun 29.

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http://dx.doi.org/10.1016/j.anai.2020.06.040DOI Listing

Shared Decision-making in Allergic Rhinitis: An Approach to the Patient.

Authors:
Gary C Steven

Ann Allergy Asthma Immunol 2020 Jun 29. Epub 2020 Jun 29.

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http://dx.doi.org/10.1016/j.anai.2020.06.032DOI Listing

House dust microbiota in relation to adult asthma and atopy in a U.S. farming population.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS), Research Triangle Park (RTP), North Carolina (NC), USA. Electronic address:

Background: Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear.

Objective: To examine associations of house dust microbiota with adult asthma, atopy, and hay fever.

Methods: Vacuumed bedroom dust samples from the homes of 879 participants (average age 62) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.013DOI Listing

Genetic impact of CDHR3 on the adult onset of asthma and COPD.

Clin Exp Allergy 2020 Jul 2. Epub 2020 Jul 2.

Department of Pulmonary Medicine, University of Tsukuba, Tsukuba, Japan.

Background: Adult-onset asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases caused by complex gene-environment interactions. A functional single nucleotide polymorphism of cadherin-related family member 3 (CDHR3), known as a receptor of rhinovirus-C, is associated with childhood-onset asthma especially in atopic individuals.

Objective: Here, we identified risk factors for adult-onset asthma and COPD, focusing on the impact of the CDHR3 variant in atopic individuals. Read More

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http://dx.doi.org/10.1111/cea.13699DOI Listing

Molecular allergen sensitization of Aspergillus fumigatus between allergic bronchopulmonary aspergillosis and A fumigatus-sensitized asthma in Guangzhou, Southern China.

J Clin Lab Anal 2020 Jul 2:e23448. Epub 2020 Jul 2.

Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Few studies have assessed the sensitization of mycotic allergens and Aspergillus fumigatus molecular allergens. This study aimed to investigate the relationships of A fumigatus components and mycotic allergens in allergic bronchopulmonary aspergillosis (ABPA) patients and A fumigatus (Af)-sensitized asthma patients.

Methods: Serum sIgE levels of Penicillium chrysogenum, Cladosporium herbarum, Mucor racemosus, Candida albicans, Alternaria alternata, Helminthosporium halodes, and A fumigatus allergen components (Asp f 1, Asp f 2, Asp f 3, Asp f 4, and Asp f 6) were measured via the ImmunoCAP assay in 18 ABPA and 54 Af-sensitized asthma patients in Guangzhou city, China. Read More

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http://dx.doi.org/10.1002/jcla.23448DOI Listing

Differences in lung clearance index and functional residual capacity between two commercial multiple-breath nitrogen washout devices in healthy children and adults.

ERJ Open Res 2020 Apr 29;6(2). Epub 2020 Jun 29.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Dept of Paediatric Pulmonology and Paediatric Allergy, Groningen, The Netherlands.

Multiple-breath nitrogen washout (MBNW) and its clinical parameter lung clearance index (LCI) are gaining increasing attention for the assessment of small airway function. Measurement of LCI relies on accurate assessment of functional residual capacity (FRC). The EasyOne Pro LAB (ndd) and Exhalyzer D (EM) are two commercially available MBNW devices. Read More

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http://dx.doi.org/10.1183/23120541.00247-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322914PMC

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation - summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019.

Clin Transl Allergy 2020 29;10:28. Epub 2020 Jun 29.

Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany.

Concerning development of medicinal products, children belong to a so-called "special population" for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use sets up a system of requirements, rewards and incentives to ensure that medicinal products are researched, developed and authorized to meet the therapeutic needs of children. Allergen Immunotherapy (AIT) is believed to contain a strong potential for immunomodulatory effects inducing sustained clinical efficacy after cessation of treatment (disease modifying effect) and thereby may prevent the progression of the atopic march towards asthma manifestation. However, to this day only few data on long-term effects in general exist and even fewer in children. Read More

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http://dx.doi.org/10.1186/s13601-020-00327-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325268PMC

Skin prick reactivity among asthmatics in East Africa.

World Allergy Organ J 2020 Jun 23;13(6):100130. Epub 2020 Jun 23.

Makerere University Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: The burden of asthma in Africa is high, and yet the disease is not universally prioritised. Data on allergic asthma and its impact on asthma morbidity are limited in Africa. Our aim was to describe the distribution of skin prick positivity among asthmatics in Eastern Africa. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322185PMC

Nasal IgE in subjects with allergic and non-allergic rhinitis.

World Allergy Organ J 2020 Jun 23;13(6):100129. Epub 2020 Jun 23.

Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.

Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.

Methods: 131 students (age 25. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322186PMC

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study.

World Allergy Organ J 2020 Jun 23;13(6):100127. Epub 2020 Jun 23.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Some studies have shown associations of maternal age at delivery with asthma and food allergy in offspring. However, the relationship between maternal age at delivery and allergic rhinitis is largely unclear. This study aimed to investigate the association between maternal age at delivery and allergic rhinitis in a population sample of Asian children, and to explore potential effect modifiers. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322179PMC

The Effect of Aerosolized Chlorpheniramine Maleate on Exercise Induced Bronchospasm and Gas Exchange in Asthmatics.

J Assoc Physicians India 2020 Apr;68(4):21-25

Sr. Professor, Department of Medicine, J.L.N. Medical College, Ajmer, Rajasthan.

Introduction: Exercise induced asthma (EIB) is an acute, reversible, usually selflimiting airways obstruction which sets in after exercise in patients with asthma. One popular mechanism of EIA is the increase in histamine and its metabolites in circulation after exercise, which leads to bronchoconstriction via histamine receptors in bronchi. Chlorpheniramine Maleate is potent, less sedative antihistaminic drug, which acts by inhibiting histamine release from mast cells. Read More

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Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Elsa Nervo, Società Chimica Italiana, 00198 Rome, Italy.

Inflammatory allergic and nonallergic respiratory disorders are spreading worldwide and often coexist. The root cause is not clear. This review demonstrates that, from a biochemical point of view, it is ascribable to protons (H) released into cells by exogenous and endogenous acids. Read More

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http://dx.doi.org/10.3390/ijerph17134688DOI Listing

Prevalence of Asthma and Asthma-like Symptoms: a Study in Five Provinces of Iran.

Tanaffos 2019 Apr;18(4):321-328

Chronic Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Asthma is a complex chronic inflammatory airway disease affecting millions of people worldwide. The prevalence of asthma attacks in most regions of the world, including the developing countries, increases due to urbanization, industrialization, and lifestyle.

Materials And Methods: The present study aimed at investigating the prevalence of asthma and asthma symptoms in five provinces of Iran using the stratified cluster sampling method and the European Community Respiratory Health Survey (ECRHS) questionnaire. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309887PMC

Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment.

Int Arch Allergy Immunol 2020 Jul 1;181(8):594-605. Epub 2020 Jul 1.

Department of Hematology and Oncology, and Institute of Pediatrics, Shenzhen Children's Hospital, Shenzhen, China.

MicroRNA (miRNA) mimics or antagomirs hold great promise for asthma treatment compared with glucocorticoids as mainstay therapy for asthma. But the role of miRNA in regulating asthmatic inflammation is largely unclear. We previously reported that miR-3162-3p in the peripheral blood of children with asthma was obviously upregulated compared to that in healthy children. Read More

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http://dx.doi.org/10.1159/000507250DOI Listing

Maternal microbiome regulation prevents early allergic airway diseases in mouse offspring.

Pediatr Allergy Immunol 2020 Jul 1. Epub 2020 Jul 1.

Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin, 130041, People's Republic of China.

Background: Asthma is a serious global health problem, severely affecting the lives of sufferers and their families. An exceptionally hygienic home and reduced microbial exposure can aggravate the incidence of childhood asthma.

Methods: Specific-pathogen-free BALB/c mice were pretreated with bacterial lysate (BL; 1 mg/kg) as a high microbial load maternal mice model, then the offspring mice were established as an allergic airway disease (AAD) model. Read More

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http://dx.doi.org/10.1111/pai.13315DOI Listing

Potential role of diacylglycerol kinases in immune-mediated diseases.

Clin Sci (Lond) 2020 Jul;134(13):1637-1658

Department of Translational Medicine, University of Eastern Piedmont, via Solaroli 17, 28100 Novara, Italy.

The mechanism promoting exacerbated immune responses in allergy and autoimmunity as well as those blunting the immune control of cancer cells are of primary interest in medicine. Diacylglycerol kinases (DGKs) are key modulators of signal transduction, which blunt diacylglycerol (DAG) signals and produce phosphatidic acid (PA). By modulating lipid second messengers, DGK modulate the activity of downstream signaling proteins, vesicle trafficking and membrane shape. Read More

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http://dx.doi.org/10.1042/CS20200389DOI Listing

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis.

Clin Transl Allergy 2020 26;10:25. Epub 2020 Jun 26.

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Via Alessandro Manzoni 56, 20089 Rozzano, MI Italy.

Background: A significant proportion of patients with severe asthma may also suffer from nasal polyposis, which is commonly defined as chronic rhinosinusitis with nasal polyps (CRSwNP), the presence of which may adversely affect asthma treatment outcomes. The biologic agent omalizumab is effective as add-on therapy in patients with severe allergic asthma. The aim of this post hoc analysis of the PROXIMA study was to compare the efficacy of omalizumab between patients with severe allergic asthma, with and without comorbid CRSwNP. Read More

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http://dx.doi.org/10.1186/s13601-020-00330-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318524PMC

Type I allergic reaction to rituximab upon first lifetime exposure: a case report.

Allergy Asthma Clin Immunol 2020 26;16:56. Epub 2020 Jun 26.

Division of Allergy and Clinical Immunology, Department of Medicine, McGill University Health Centre, McGill University, Montreal, QC Canada.

Background: While drug reactions to rituximab have been commonly reported in the literature, a type I allergic reaction to rituximab after first lifetime exposure has never been reported.

Case Presentation: We describe a case of a 58-year-old female patient who received rituximab for the first time for treatment of rheumatoid arthritis. She developed symptoms immediately after infusion, however presented 11 days after drug exposure with cyclical anaphylaxis-like reaction requiring multiple doses of epinephrine. Read More

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http://dx.doi.org/10.1186/s13223-020-00448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318363PMC

Day and Night Control of COPD and Role of Pharmacotherapy: A Review.

Int J Chron Obstruct Pulmon Dis 2020 4;15:1269-1285. Epub 2020 Jun 4.

Department of Biomedicine and Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy.

The topic of 24-hour management of COPD is related to day-to-night symptoms management, specific follow-up and patients' adherence to therapy. COPD symptoms strongly vary during day and night, being worse in the night and early morning. This variability is not always adequately considered in the trials. Read More

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http://dx.doi.org/10.2147/COPD.S240033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283230PMC

Comparison of exacerbation phenotypes among patients with severe asthma.

Allergy Asthma Proc 2020 Jul;41(4):e67-e79

From the Duke NUS Medical School, Singapore.

Exacerbation phenotypes among patients with severe asthma have been largely characterized during stable periods. Little is known about severe asthma patients during exacerbation periods. To compare persistently frequent exacerbators (PFE), non-persistently frequent exacerbators (NPFE), and infrequent exacerbators (IFE) among patients with severe asthma during stable and exacerbation periods. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200029DOI Listing

For the Patient.

Authors:

Allergy Asthma Proc 2020 Jul;41(4):309

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http://dx.doi.org/10.2500/aap.2020.41.200049DOI Listing

POPS case: A 30-year-old Filipino woman with fevers, lymphadenopathy, painful scalp lesions, and a neck mass.

Allergy Asthma Proc 2020 Jul;41(4):305-308

Division of Hospital Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

We described a case of a 30-year-old Filipino woman who presented with fevers, night sweats, left hip pain, painful scalp lesions, and a neck mass. Symptoms began 6 months earlier, with nasal drainage, fever, cough, and occasional hemoptysis, which did not resolve with outpatient antibiotics. A further workup revealed lymphadenopathy and several lytic bone lesions. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200012DOI Listing

Pearls and pitfalls: Cold-induced urticaria.

Allergy Asthma Proc 2020 Jul;41(4):301-304

Division of Allergy and Immunology, Naval Medical Center Portsmouth, Portsmouth, Virginia.

Cold-induced urticaria can take place either due to direct cold exposure, cryoglobulinemia, or genetic component (such as cryopyrin-associated periodic syndrome), which leads to the rapid onset of urticaria and/or angioedema. It is more common in younger patients and more likely to affect females compared with males. To increase awareness of such systemic reactions of anaphylaxis and provide a focused review of the differential diagnosis, underlying mechanisms, broad workup, and management of this disease process for allergy/immunology fellows, residents, general physicians, and general practitioners. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200033DOI Listing

Successful treatment of coronavirus disease 2019 in a patient with asthma.

Allergy Asthma Proc 2020 Jul;41(4):296-300

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases the risk for severe COVID-19 infection. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200044DOI Listing

What is in your pantry? Entomologic anaphylaxis.

Allergy Asthma Proc 2020 Jul;41(4):290-295

From the Department of Internal Medicine, Division of Rheumatology, Allergy & Immunology, University of California San Diego, San Diego, CA.

The booklouse, Liposcelis bostrychophila, is a potent environmental allergen clinically associated with rhinoconjunctivitis and asthma. Despite its known infestation of grain products, anaphylaxis from ingestion of this organism has, to our knowledge, not been previously reported. We present the case of a 44-year-old woman who developed anaphylaxis to ingested oats and rice shown to be contaminated with L. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200030DOI Listing

Negative predictive value of provocation tests for nonsteroidal anti-inflammatory drugs in children.

Allergy Asthma Proc 2020 Jul;41(4):285-289

From the Division of Pediatric Allergy and Immunology, Ankara City Hospital, Ankara, Turkey.

After antibiotics, nonsteroidal anti-inflammatory drugs (NSAID) are one of the leading drug classes responsible for hypersensitivity reactions in children. The drug provocation test (DPT) is the criterion standard for diagnosis. The aim of the present study was to determine the negative predictive values (NPV) of DPTs with NSAIDs in pediatric patients and to evaluate their attitudes toward NSAID use after a negative DPT result. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200032DOI Listing

Long-term efficacy of injected allergen immunotherapy for treatment of grass pollen allergy in elderly patients with allergic rhinitis.

Allergy Asthma Proc 2020 Jul;41(4):271-277

Humanitas Research Hospital, Milano, Italy.

The effect of prolonged allergen immunotherapy is still insufficiently known, especially in elderly patients. The effect after a 3-year course of injected allergen-specific immunotherapy (AIT) for grass pollen allergy in elderly patients with allergic rhinitis was observed. Thirty-eight elderly patients (mean ± standard deviation, 66. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200035DOI Listing

Adherence and usage patterns of inhaled corticosteroids-long-acting beta-agonists by using inhaler-monitoring technology.

Allergy Asthma Proc 2020 Jul;41(4):256-264

Optum, Eden Prairie, Minnesota.

Results of previous research indicate that adherence to prescribed inhaled corticosteroid-long-acting beta2-agonist (ICS-LABA) asthma controller medications is suboptimal, yet actual daily-use patterns are unclear and may be influenced by regimen complexity or dosing frequency. To investigate real-world use of asthma medications by using inhaler sensors for the ICS-LABA controllers: twice-daily fluticasone propionate (FP) plus salmeterol (SAL) and once-daily fluticasone furoate (FF) plus vilanterol (VI); and albuterol rescue medication. This longitudinal, two-phase, observational study included adults with asthma-prescribed FP-SAL (phase I) or FF-VI (phase II), and albuterol metered-dose inhalers. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200037DOI Listing

The role of serum periostin in the diagnosis of asthma: A meta-analysis.

Allergy Asthma Proc 2020 Jul;41(4):240-247

From the Department of Pediatrics, Bethune International Peace Hospital of Chinese PLA, Shijiazhuang 050082, Hebei, People's Republic of China; and.

Serum periostin has been proposed as a noninvasive biomarker for asthma diagnosis and management. However, its accuracy for the diagnosis of asthma in different populations is not completely clear. This meta-analysis aimed to evaluate the diagnostic accuracy of periostin level in the clinical determination of asthma. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200038DOI Listing

Treatment with azelastine hydrochloride and fluticasone propionate in a single delivery device of young children and adolescents with allergic rhinitis.

Allergy Asthma Proc 2020 Jul;41(4):232-239

Clinic of Occupational Diseases, University Hospital Sv. Ivan Rilski, Sofia, Bulgaria.

Allergic rhinitis (AR) is the most common chronic noncommunicable disease worldwide that affects any age during the human life span but raises particular concerns among the parents and caregivers of the children who are affected. H-receptor antagonists and corticosteroids provide the most effective way of bringing the condition under control. Intranasal application of these medications has the advantage of a faster onset of action and avoids systemic unwanted adverse effects. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200034DOI Listing

A case of Asthma with Behcet's disease: successful treatment with Omalizumab and its effects on recurrent aphthous lesions.

Immunopharmacol Immunotoxicol 2020 Jul 1:1-12. Epub 2020 Jul 1.

Department of Infectious Diseases and Clinical Microbiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Monoclonal antibody therapies have revolutionized the treatment of autoinflammatory-immune/genetic disease including spondylarthritis, asthma and rheumatoid arthritis. Behcet's disease (BD) is a multi-systemic vasculitis, which is generally recurrent aphthous lesions (RAL) as well as ocular and skin lesions. Today, the immunohistopathogenesis of BD is mostly unknown. Read More

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http://dx.doi.org/10.1080/08923973.2020.1789656DOI Listing

Recurrence of eosinophilic inflammation and worsening asthma symptoms between doses of benralizumab.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Centre de recherche de l'Hôpital du Sacré-Cœur de Montréal, Université de Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.06.037DOI Listing

SARS-CoV-2 pneumonia in hospitalized asthmatic patients did not induce severe exacerbation.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Chest diseases department, Strasbourg University Hospital, France; Public Health Department, Strasbourg University Hospital, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, France. Electronic address:

Background: Viral infections are known to exacerbate asthma in adults. Previous studies have found few asthmatics among SARS-CoV-2 pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320869PMC

COVID-19: Unmasking Telemedicine.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Division of Pulmonary, Allergy and Critical Care, Department of Medicine, NorthShore University HealthSystem, Evanston, IL. Electronic address:

Telemedicine adoption has rapidly accelerated since the onset of the COVID-19 pandemic. Telemedicine provides increased access to medical care and helps to mitigate risk by conserving personal protective equipment and providing for social/physical distancing in order to continue to treat patients with a variety of allergic and immunologic conditions. During this time, many allergy and immunology clinicians have needed to adopt telemedicine expeditiously in their practices while studying the complex and variable issues surrounding its regulation and reimbursement. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320693PMC

A Review of Shared Decision-Making: A Call to Arms for healthcare professionals.

Ann Allergy Asthma Immunol 2020 Jun 27. Epub 2020 Jun 27.

Professor of Clinical Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1016/j.anai.2020.06.030DOI Listing

The latest on the role of LAMAs in asthma.

J Allergy Clin Immunol 2020 Jun 27. Epub 2020 Jun 27.

Unit of Pharmacology, Dept. Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

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http://dx.doi.org/10.1016/j.jaci.2020.06.014DOI Listing

Circulating IL-4, IFNγ and IL-17 conventional and Innate-like T cell producers in adult asthma.

Allergy 2020 Jun 30. Epub 2020 Jun 30.

Inserm UMR1152, Physiopathologie et Epidémiologie des Maladies Respiratoires, Paris, France.

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http://dx.doi.org/10.1111/all.14474DOI Listing

Age-of-onset information helps identify 76 genetic variants associated with allergic disease.

PLoS Genet 2020 Jun 30;16(6):e1008725. Epub 2020 Jun 30.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008725DOI Listing

Assessment of Poor Inhaler Technique in Older Patients with Asthma or COPD: A Predictive Tool for Clinical Risk and Inhaler Performance.

Drugs Aging 2020 Jun 30. Epub 2020 Jun 30.

CICS-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.

Background/objectives: Older patients with asthma or chronic obstructive pulmonary disease (COPD) are particularly susceptible to inhaler technique errors and poor clinical outcomes. Several factors may influence their risk, but most studies are inconsistent and contradictory. We developed a tool for the major predictors of individual risk in these patients. Read More

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http://dx.doi.org/10.1007/s40266-020-00779-6DOI Listing

Eicosanoids seasonally impact pulmonary function in asthmatic patients with Japanese cedar pollinosis.

Allergol Int 2020 Jun 26. Epub 2020 Jun 26.

Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.

Background: Condition of asthma in patients with asthma and concomitant seasonal allergic rhinitis (SAR) deteriorates during the Japanese cedar pollen (JCP) season. However, the underlying mechanisms remain unclear.

Methods: We analyzed seasonal variations in eicosanoid levels in the airways of patients with asthma and concomitant SAR sensitized to JCP (N = 29, BA-SAR-JCP group) and those not sensitized (N = 13, BA-AR-non-JCP group) during the JCP season. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.014DOI Listing

Progress in Occupational Asthma.

Int J Environ Res Public Health 2020 Jun 24;17(12). Epub 2020 Jun 24.

Medical University Sofia, 1000 Sofia, Bulgaria.

Occupational asthma (OA) represents one of the major public health problems due to its high prevalence, important social and economic burden. The aim of this review is to summarize current data about clinical phenotypes, biomarkers, diagnosis and management of OA, a subtype of work-related asthma. Most studies have identified two phenotypes of OA. Read More

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http://dx.doi.org/10.3390/ijerph17124553DOI Listing

The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma.

Int Arch Allergy Immunol 2020 Jun 29:1-10. Epub 2020 Jun 29.

Division of Haematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Introduction: Obesity-associated asthma is characterized by type 2-low airway inflammation. We previously showed that EM900, which is a 12-membered nonantibiotic macrolide, suppressed airway inflammation in a mouse model of asthma exacerbation. The aim of this study was to clarify the effects of EM900 in obesity-associated asthma. Read More

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http://dx.doi.org/10.1159/000508709DOI Listing

Drug Associated Inducible Laryngeal Obstruction Complicating Penicillin Allergy Testing.

Ann Allergy Asthma Immunol 2020 Jun 26. Epub 2020 Jun 26.

Department of Internal Medicine Division of Allergy & Immunology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX, 75390-8859. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.06.031DOI Listing

The first case of tegoprazan-induced urticaria.

J Clin Pharm Ther 2020 Jun 29. Epub 2020 Jun 29.

Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

What Is Known And Objective: Tegoprazan induces adverse drug reactions during clinical trials; however, tegoprazan-induced urticaria has not been reported. Here, we describe the first case of this.

Case Description: A 55-year-old woman presented with acute urticaria with pruritus after taking the gastro-oesophageal reflux disease medication, tegoprazan. Read More

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http://dx.doi.org/10.1111/jcpt.13150DOI Listing

A new approach to categorization of radiologic inflammation in chronic rhinosinusitis.

PLoS One 2020 29;15(6):e0235432. Epub 2020 Jun 29.

Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Chronic rhinosinusitis (CRS) is a prevalent condition. Clinical diagnosis requires subjective evidence (i.e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235432PLOS

Real-life data.

Authors:
Graham Roberts

Clin Exp Allergy 2020 Jul;50(7):764-765

Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/cea.13684DOI Listing

Outdoor air pollutants exposure associated with pulmonary function and exhaled breath condensate pH value in atopic asthmatic and non-asthmatic children.

J Asthma 2020 Jun 27:1-11. Epub 2020 Jun 27.

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan, Taiwan;

Air pollution is associated with the prevalence of respiratory diseases. This study aimed to evaluate the impacts of outdoor air pollutants and indoor 1 ( 1) exposure on levels of fractional exhaled nitric oxide (FeNO), exhaled breath condensate (EBC) pH, and pulmonary function in atopic children. This study recruited 59 atopic mild-to-moderate asthmatic children and 23 atopic non-asthmatic children. Read More

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http://dx.doi.org/10.1080/02770903.2020.1788075DOI Listing

Aspirin-exacerbated respiratory disease: A review.

Laryngoscope Investig Otolaryngol 2020 Jun 1;5(3):360-367. Epub 2020 May 1.

Division of Otolaryngology-Head and Neck Surgery Brigham and Women's Hospital Boston Massachusetts USA.

Objectives: Aspirin-exacerbated respiratory disease (AERD) is a chronic respiratory condition characterized by a triad of symptoms: asthma, chronic rhinosinusitis with nasal polyposis, and a respiratory reaction to aspirin and other cyclooxygenase-1 inhibitors, also known as nonsteroidal anti-inflammatory drugs. The objective of this review is to provide otolaryngologists with an overview of the pathophysiology, diagnosis, and treatment of this under-recognized condition.

Data Sources And Methods: Foundational papers on AERD were reviewed, focusing on the clinical otolaryngology and allergy/immunology literature and other high impact journals or trials. Read More

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http://dx.doi.org/10.1002/lio2.387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314471PMC