147,736 results match your criteria Allergy Asthma & Clinical Immunology [Journal]


TNF-TNFR2 Signaling Inhibits Th2 and Th17 Polarization and Alleviates Allergic Airway Inflammation.

Int Arch Allergy Immunol 2019 Feb 14:1-10. Epub 2019 Feb 14.

Department of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: TNF-TNFR2 signaling has been indicated to be involved in CD4+ T lymphocyte differentiation. However, its role in allergic airway inflammation is not well understood.

Objectives: The aim of this study was to investigate the role of TNF-TNFR2 signaling in allergic airway inflammation. Read More

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http://dx.doi.org/10.1159/000493583DOI Listing
February 2019

The role of early life food sensitization in adolescent lung function: Results from two birth cohort studies.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia;; Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:

Background: It is unclear whether early life food sensitization (as opposed to aeroallergen sensitization) is associated with subsequent poor lung function.

Objectives: We investigated the associations between food sensitization in the first two years of life and lung function at 12 to 18 years and whether these observed associations are mediated through aeroallergen sensitization or asthma.

Methods: We used data from a high-risk cohort (MACS) and a population-based (LISAplus) cohort. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.050DOI Listing
February 2019

Vitamin D status modifies the response to indoor particulate matter in obese urban children with asthma.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Department of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address:

Background: Indoor fine particulate air pollution (PM) is linked to asthma morbidity; however, whether vitamin D status influences individual susceptibility to airborne exposures is unclear.

Objective: We aimed to determine if vitamin D modifies effects of indoor PM upon asthma symptoms in urban children.

Methods: 120 children aged 5-12 years with physician-diagnosed asthma were evaluated at baseline and every 3 months for 9 months. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.051DOI Listing
February 2019

Broad Immunglobulin G Repertoire in Chronic Rhinosinusitis with Nasal Polyps regulates pro-inflammatory IgE responses.

J Allergy Clin Immunol 2019 Feb 11. Epub 2019 Feb 11.

Upper Airways Research Laboratory, Ghent University, Ghent, Belgium; Division of ENT Diseases, CLINTEC, Karolinska Institute, Stockholm, Sweden.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE-idiotypes. Whilst tissue IgE concentrations can be in the range of several thousand kU/L, the regulatory mechanisms by which IgE-mediated inflammation is controlled in the nasal polyps is not well understood.

Objective: We sought to determine whether locally induced IgG antibodies in the nasal polyps can inhibit IgE-mediated pro-allergic response. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.001DOI Listing
February 2019

DNA methylation and allergic sensitizations, a genome-scale longitudinal study during adolescence.

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Sachs' Children's Hospital, Stockholm, Sweden.

Background: The presence of allergic sensitization has a major influence on the development and course of common childhood conditions such as asthma and rhinitis. The etiology of allergic sensitization is poorly understood and its underlying biological mechanisms are not well established. Several studies showed that DNA methylation (DNAm) at some CpGs is associated with allergic sensitization. Read More

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http://dx.doi.org/10.1111/all.13746DOI Listing
February 2019

Type 3 ILCs in Lung Disease.

Front Immunol 2019 29;10:92. Epub 2019 Jan 29.

Africa Health Research Institute, Durban, South Africa.

The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361816PMC
January 2019

Epigenetic findings in periodontitis in UK twins: a cross-sectional study.

Clin Epigenetics 2019 Feb 13;11(1):27. Epub 2019 Feb 13.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.

Background: Genetic and environmental risk factors contribute to periodontal disease, but the underlying susceptibility pathways are not fully understood. Epigenetic mechanisms are malleable regulators of gene function that can change in response to genetic and environmental stimuli, thereby providing a potential mechanism for mediating risk effects in periodontitis. The aim of this study is to identify epigenetic changes across tissues that are associated with periodontal disease. Read More

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http://dx.doi.org/10.1186/s13148-019-0614-4DOI Listing
February 2019

Asthma and atopy prevalence are not reduced among former tuberculosis patients compared with controls in Lima, Peru.

BMC Pulm Med 2019 Feb 13;19(1):40. Epub 2019 Feb 13.

The University of Sydney, St. Vincent's Hospital Sydney, Heart Lung Clinic, Xavier Building. 390, Victoria Street, 2010, Australia.

Background: Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

Objective: To determine if people with confirmed tuberculosis were less likely to be atopic and less likely to have atopic disease including asthma compared to those with no previous tuberculosis.

Methods: Patients in Lima, Peru with a prior history of tuberculosis were identified from clinic records in this cohort study. Read More

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http://dx.doi.org/10.1186/s12890-019-0804-zDOI Listing
February 2019

Development of a gold nanoparticle-labeled sandwich format lateral flow immunoassay kit for the detection of tropical house dust mite Suidasia pontifica.

Protein Pept Lett 2019 Feb 12. Epub 2019 Feb 12.

The Graduate School, bCollege of Science, University of Santo Tomas, España Boulevard, Sampaloc 1015, Manila. Philippines.

The house dust mite Suidasia pontifica (Sp) is an important source of allergens in tropical regions that trigger IgE-mediated allergic reactions such as allergic asthma, atopic dermatitis and allergic rhinitis. Detection of Sp-specific proteins are important in the management and prevention of allergic diseases. The study aimed to provide a proof of concept for a gold nanoparticle-labeled sandwich format lateral flow immunoassay (LFIA) kit for the detection of Sp-specific proteins. Read More

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http://dx.doi.org/10.2174/0929866526666190212164751DOI Listing
February 2019

Patterns in Google Trends Terms Reporting Rhinitis and Ragweed Pollen Season in Ukraine.

Int Arch Allergy Immunol 2019 Feb 13:1-7. Epub 2019 Feb 13.

University Hospital, Montpellier, France.

Background: Google Trends (GT) may represent a new approach to assessing pollen allergy. However, the development of a pan-European sentinel network has raised a problem of translating terms in different languages. A precise definition of the pollen season onset is crucial for the confirmation of a pollen allergy diagnosis and personalized treatment. Read More

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http://dx.doi.org/10.1159/000495306DOI Listing
February 2019

Beneficial Effect of Early Intervention with Garenoxacin for Bacterial Infection-Induced Acute Exacerbation of Bronchial Asthma and Chronic Obstructive Pulmonary Disease.

Int Arch Allergy Immunol 2019 Feb 13:1-8. Epub 2019 Feb 13.

Division of Allergology and Respiratory Medicine, Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Chronic obstructive pulmonary disease (COPD) and asthma have similar clinical features and are both exacerbated by airway infection.

Objective: To determine whether garenoxacin mesylate hydrate (GRNX) added to the standard care for bacterial infection-induced acute exacerbation of asthma or COPD in adults has clinical benefits.

Method: This single-arm clinical trial was conducted from January 2015 to March 2016. Read More

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http://dx.doi.org/10.1159/000495761DOI Listing
February 2019

Regulation of Interaction between the Upper and Lower Airways in United Airway Disease.

Med Sci (Basel) 2019 Feb 11;7(2). Epub 2019 Feb 11.

Department of Otolaryngology, Head and Neck Surgery, Kansai Medical University, Hirakata, 573-1010, Japan.

The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation. The treatment of upper airway inflammation reduces asthma symptoms and decreases the dose of inhaled corticosteroids (ICS) necessary to treat asthma. Read More

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http://dx.doi.org/10.3390/medsci7020027DOI Listing
February 2019

Outcome measures to be considered on asthma in elderly.

Curr Opin Allergy Clin Immunol 2019 Feb 8. Epub 2019 Feb 8.

Regional Center of Allergy and Clinical Immunology, Universidad Autonoma de Nuevo León.

Purpose Of Review: Asthma is a chronic heterogeneous respiratory disease which is characterized by airflow limitation and variable respiratory symptoms. Asthma in patients more than 65 years of age has an important negative impact on quality of life. The pathophysiology and treatment of asthma in older patients are not as well identified as in younger groups of ages. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000525DOI Listing
February 2019

Investigating asthma, allergic disease, passive smoke exposure, and risk of rheumatoid.

Arthritis Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Mayo Clinic, Rheumatology, Mayo Building, 15-73E, 200 1st St SW, Rochester, Minnesota, United States.

Objective: Rheumatoid Arthritis (RA) is postulated to originate at mucosal surfaces, particularly the airway mucosa. To investigate this hypothesis, we determined the association between RA and asthma, passive smoke exposure, and age of starting smoking.

Methods: This case-control study identified 1,023 cases of RA (175 incident) within a single-center biobank population using a rules-based algorithm that combined self-report with two diagnosis codes. Read More

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http://dx.doi.org/10.1002/art.40858DOI Listing
February 2019

Sampling Devices for Indoor Allergen Exposure: Pros and Cons.

Curr Allergy Asthma Rep 2019 Feb 12;19(1). Epub 2019 Feb 12.

Departments of Population Health and Pediatrics, Dell Medical School, The University of Texas at Austin, 1701 Trinity St., Stop Z0500, Austin, TX, 78712, USA.

Purpose Of Review: To review current indoor allergen sampling devices, including devices to measure allergen in reservoir and airborne dust, and personal sampling devices, with attention to sampling rationale and major indoor allergen size and characteristics.

Recent Findings: While reservoir dust vacuuming samples and airborne dust volumetric air sampling remain popular techniques, recent literature describes sampling using furnace filters and ion-charging devices, both which help to eliminate the need for trained staff; however, variable correlation with reservoir dust and volumetric air sampling has been described. Personal sampling devices include intra-nasal samples and personal volumetric air samples. Read More

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http://dx.doi.org/10.1007/s11882-019-0833-yDOI Listing
February 2019

The role of patient-reported outcomes in the management of chronic spontaneous urticaria.

Authors:
Kate Hopkinson

Br J Nurs 2019 Feb;28(3):144-150

Allergy Nurse Specialist, Department of Clinical Immunology and Allergy, Nottingham University Hospitals NHS Trust.

Chronic spontaneous urticaria (CSU) is a debilitating condition that can substantially affect patients' quality of life (QoL), mental health and ability to perform daily tasks. International guidelines on the management of CSU, jointly developed by the European Academy of Allergy and Clinical Immunology (EAACI), Global Allergy and Asthma European Network (GALEN), European Dermatology Forum (EDF) and World Allergy Organization (WAO), recommend a treat-to-target strategy until symptom control or remission is achieved. This may mean stepping up or down in the treatment algorithm according to the course of CSU and re-evaluating the need for continued/alternative drug treatment. Read More

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http://www.magonlinelibrary.com/doi/10.12968/bjon.2019.28.3.
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http://dx.doi.org/10.12968/bjon.2019.28.3.144DOI Listing
February 2019
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Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough.

J Thorac Dis 2018 Dec;10(12):6616-6623

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100000, China.

Background: Chronic cough is a common symptom in children. We wished to explore the value of fractional exhaled nitric oxide (FeNO) for cough-variant asthma (CVA) in children with chronic cough.

Methods: This prospective cohort study was conducted in the Children's Hospital of Soochow University from January 2012 to December 2014. Read More

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http://dx.doi.org/10.21037/jtd.2018.11.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344719PMC
December 2018

Evaluation of Peripheral Blood Eosinophilia in Adolescent and Adult Patients Suffering from Atopic Dermatitis and the Relation to the Occurrence of Allergy to Aeroallergens.

Indian J Dermatol 2019 Jan-Feb;64(1):34-40

Department of Clinical Immunology and Allergy, Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic.

Background: Eosinophils play an important pathogenic role in atopic dermatitis (AD), but its exact function remains to be determined.

Aims And Objectives: The aim of this study was to correlate the eosinophil count with the manifestations such as asthma bronchiale, rhinitis, level of total IgE, sensitization to mites, animal dander, bird feather, dust, mixture of grass, mixture of trees, mixture of fungi, duration of lesions (persistent or occasional during last year), family history about atopy, and onset of AD (under or above 5 year of age).

Materials And Methods: Two hundred and seventy-two patients suffering from AD at the age of 14 year or older were examined - 100 men and 172 women with the average age of 26. Read More

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http://dx.doi.org/10.4103/ijd.IJD_509_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340239PMC
February 2019

α-Galactosylceramide treatment before allergen sensitization promotes iNKT cell-mediated induction of Treg cells, preventing Th2 cell responses in murine asthma.

J Biol Chem 2019 Feb 11. Epub 2019 Feb 11.

Renmin Hospital of Wuhan University, China.

Asthma is a common inflammatory pulmonary disorder involving a diverse array of immune cells such as proinflammatory T helper 2 (Th2) cells. We recently reported that intraperitoneal injection of α-galactosylceramide (α-GalCer) can stimulate lung invariant natural killer T (iNKT) cells and does not lead to airway inflammation in WT mice. Other studies indicate that iNKT cells play an important role in inducing regulatory T cells (Treg cells) and peripheral tolerance. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005418DOI Listing
February 2019

Prevalence of asthma, allergic rhinitis and eczema in 6-7-year-old schoolchildren from Luanda, Angola.

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Department of Allergy & Clinical Immunology, Cova da Beira University Hospital, Quinta do Alvito, 6200-251 Covilhã, Portugal; CICS - Health Sciences Research Centre, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal. Electronic address:

Background: Epidemiological data have shown that the prevalence of asthma, rhinoconjunctivitis and eczema in children is still increasing, namely in Africa. However, there are no epidemiological studies on asthma or allergic diseases in Angolan children.

Objective: To study the prevalence of asthma and other allergic diseases in Angolan children. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.002DOI Listing
February 2019

What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study.

Respir Res 2019 Feb 11;20(1):29. Epub 2019 Feb 11.

School of Engineering, University of Warwick, Coventry, UK.

Background: Recent analyses of patient data in acute respiratory distress syndrome (ARDS) showed that a lower ventilator driving pressure was associated with reduced relative risk of mortality. These findings await full validation in prospective clinical trials.

Methods: To investigate the association between driving pressures and ventilator induced lung injury (VILI), we calibrated a high fidelity computational simulator of cardiopulmonary pathophysiology against a clinical dataset, capturing the responses to changes in mechanical ventilation of 25 adult ARDS patients. Read More

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http://dx.doi.org/10.1186/s12931-019-0990-5DOI Listing
February 2019

Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells.

Environ Int 2019 Feb 7;125:350-364. Epub 2019 Feb 7.

Department of Immunology, Medical University of Bialystok, Poland.

Endocrine disrupting chemicals (EDCs) are added to food, cosmetics, plastic packages, and children's toys and have thus become an integral part of the human environment. In the last decade, there has been increasing interest in the effect of EDCs on human health, including their impact on the immune system. So far, researchers have proved that EDCs (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183196
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http://dx.doi.org/10.1016/j.envint.2019.01.078DOI Listing
February 2019
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Eliminating health disparities in asthma: are we at the end of the beginning?

Ann Allergy Asthma Immunol 2019 Feb 8. Epub 2019 Feb 8.

Division of Pediatric Pulmonary Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.02.001DOI Listing
February 2019

Emerging Triggers of FPIES: Lessons from a Pediatric Cohort of 74 Children in the US.

Ann Allergy Asthma Immunol 2019 Feb 8. Epub 2019 Feb 8.

Baylor College of Medicine, Section of Pediatric Immunology, Allergy and Rheumatology Houston, TX; Texas Children's Hospital, Department of Pediatrics, Section of Immunology, Allergy and Rheumatology, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.01.022DOI Listing
February 2019

Characteristics of Inner City Children with Life-Threatening Asthma.

Ann Allergy Asthma Immunol 2019 Feb 8. Epub 2019 Feb 8.

Morphew Consulting, LLC, Bothell, WA.

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http://dx.doi.org/10.1016/j.anai.2019.02.002DOI Listing
February 2019

Innate Lymphoid Cells of the Lung.

Annu Rev Physiol 2019 Feb;81:429-452

Medical Research Council, Laboratory of Molecular Biology, Cambridge University, Cambridgeshire CB2 0QH, United Kingdom; email:

Although, as the major organ of gas exchange, the lung is considered a nonlymphoid organ, an interconnected network of lung-resident innate cells, including epithelial cells, dendritic cells, macrophages, and natural killer cells is crucial for its protection. These cells provide defense against a daily assault by airborne bacteria, viruses, and fungi, as well as prevent the development of cancer, allergy, and the outgrowth of commensals. Our understanding of this innate immune environment has recently changed with the discovery of a family of innate lymphoid cells (ILCs): ILC1s, ILC2s, and ILC3s. Read More

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http://dx.doi.org/10.1146/annurev-physiol-020518-114630DOI Listing
February 2019

Parental asthma and risk of autism spectrum disorder in offspring: a population and family based case-control study.

Clin Exp Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Associations between parental asthma and prenatal exposure to asthma medications with offspring autism spectrum disorder (ASD) have been reported. However, the associations might be confounded by unmeasured (genetic and shared environmental) familial factors.

Objective: We investigated the association between (a) maternal/paternal asthma and offspring ASD, and (b) prenatal exposures to β2-agonists, other asthma medications and offspring ASD using cases and controls selected from the population as well as biological relatives with different degrees of relatedness. Read More

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http://doi.wiley.com/10.1111/cea.13353
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http://dx.doi.org/10.1111/cea.13353DOI Listing
February 2019
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Effect of the Fexofenadine on the expression of HRH-1 and HRH-4 receptor in Peripheral Blood Mononuclear Cell isolated from children with diagnosed allergy - in vitro study Short communication.

J Pharm Pharm Sci 2019 ;22(1):93-97

Department of Biology and Biotechnology, University of Warmia and Mazury, Oczapowskiego 1A Street, 10-719 Olsztyn, Poland.

Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic diseases such as allergic rhinitis, asthma and dermatitis. The pleiotropic effects of histamine are mediated by four types of receptors that belong to the G-protein-coupled receptor family: histamine H1 receptor (HRH-1), histamine H2 receptor, histamine H3 receptor, and histamine H4 receptor. Read More

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http://dx.doi.org/10.18433/jpps29971DOI Listing
January 2019
1 Read

Environmental exposures and mechanisms in allergy and asthma development.

J Clin Invest 2019 Feb 11. Epub 2019 Feb 11.

Division of Asthma Research, Cincinnati Children's Medical Center, Cincinnati, Ohio, USA.

Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Research shows an association between the rise of allergic diseases and increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, and antibiotic usage. Read More

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https://www.jci.org/articles/view/124612
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http://dx.doi.org/10.1172/JCI124612DOI Listing
February 2019
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Clinical factors associated with the overuse of asthma rescue medication.

J Investig Allergol Clin Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d´Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain.

Background And Objective: Our aim was to evaluate the relationship between asthma clinical factors and use of relief medication.

Methods: This was an observational cross-sectional study conducted in Spain. The study recruited patients ≥ 12 years of age diagnosed with persistent asthma according to the GINA criteria and receiving maintenance treatment for at least 12 months. Read More

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http://dx.doi.org/10.18176/jiaci.0387DOI Listing
February 2019

Obesity Trends among Asthma Patients in the United States: A Population-based Study.

Ann Glob Health 2019 Jan 22;85(1). Epub 2019 Jan 22.

Division of General Internal Mediine, Icahn School of Medicine at Mount Sinai, NY.

Background: Obesity is strongly associated with worse asthma control and poorer quality of life. The current obesity epidemic has reached historically high levels, with an estimated prevalence rate of 37% in the general United States (US) population. However, less is known about trends in the prevalence of obesity among individuals with asthma or which sociodemographic groups are at higher risk for increased weight. Read More

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http://dx.doi.org/10.5334/aogh.2420DOI Listing
January 2019

Effect of Sex on Group 2 Innate Lymphoid Cells in the Airways of Mild and Severe Asthmatics.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Cardiorespiratory Research, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1111/all.13742DOI Listing
February 2019

Exposure to indoor endocrine disrupting chemicals and childhood asthma and obesity.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto Portugal & Centro Hospitalar São João, Porto, Portugal.

Background: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren. Read More

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http://dx.doi.org/10.1111/all.13740DOI Listing
February 2019

School-aged asthma children with high fractional exhaled nitric oxide levels and lung dysfunction are at high risk of prolonged lung dysfunction.

Asia Pac Allergy 2019 Jan 24;9(1):e8. Epub 2019 Jan 24.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Background: Long-term management of bronchial asthma based on the fractional exhaled nitric oxide (FeNO) value alone is not conclusive yet. Therefore, we combined FeNO testing and spirometry, a commonly used test in routine practice, to evaluate acute exacerbation and respiratory function in children with bronchial asthma.

Objective: We combined FeNO testing and spirometry, commonly used in routine practice, to evaluate acute exacerbations and respiratory function in children with bronchial asthma. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365655PMC
January 2019

Omalizumab and unmet needs in severe asthma and allergic comorbidities in Japanese children.

Asia Pac Allergy 2019 Jan 22;9(1):e7. Epub 2019 Jan 22.

University of Manchester, Manchester, UK.

Childhood asthma is one condition within a family of allergic diseases, which includes allergic rhinitis, atopic dermatitis, and food allergy, among others. Omalizumab is an anti-IgE antibody therapy that was approved in Japan for children with asthma and added to the Japanese pediatric asthma guidelines in 2017. This review highlights the Japanese clinical perspectives in pediatric allergic asthma, and consideration for allergic comorbidities, and reflects on omalizumab clinical trials in progress to present comprehensive future opportunities. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365659PMC
January 2019
1 Read

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study.

Asia Pac Allergy 2019 Jan 21;9(1):e5. Epub 2019 Jan 21.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Background: Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.

Objectives: The present study was aimed to examine such exposure among Japanese individuals with allergic diseases. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5415/apallergy.2
Publisher Site
http://dx.doi.org/10.5415/apallergy.2019.9.e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365653PMC
January 2019
1 Read

A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy.

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

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http://dx.doi.org/10.5415/apallergy.2019.9.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365661PMC
January 2019
1 Read

Physiotherapy improves symptoms of exercise-induced laryngeal obstruction in young elite athletes: a case series.

BMJ Open Sport Exerc Med 2019 23;5(1):e000487. Epub 2019 Jan 23.

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.

Objective: A constricted, upper chest breathing pattern and postural dealignments habitually accompany exercise-induced laryngeal obstruction (EILO), but there are few effective treatments for athletes presenting with EILO. This case series was conducted to examine whether physiotherapy based on principles from the Norwegian psychomotor physiotherapy (NPMP) combined with elements of cognitive behavioural therapy can reduce laryngeal distress in athletes with EILO.

Methods: Respiratory distress in four subjects was examined by interview prior to a physiotherapeutic body examination. Read More

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http://dx.doi.org/10.1136/bmjsem-2018-000487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347884PMC
January 2019
1 Read

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement.

Clin Transl Allergy 2019 4;9. Epub 2019 Feb 4.

1ENT Clinical Department, University Hospital Leuven, Kapucijnenvoer 33, 3000 Louvain, Belgium.

Allergic rhinitis (AR) affects 23-30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Read More

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http://dx.doi.org/10.1186/s13601-019-0243-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360767PMC
February 2019
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Nitration of Wheat Amylase Trypsin Inhibitors Increases Their Innate and Adaptive Immunostimulatory Potential .

Front Immunol 2018 21;9:3174. Epub 2019 Jan 21.

Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany.

Amylase trypsin inhibitors (ATI) can be found in all gluten containing cereals and are, therefore, ingredient of basic foods like bread or pasta. In the gut ATI can mediate innate immunity via activation of the Toll-like receptor 4 (TLR4) on immune cells residing in the lamina propria, promoting intestinal, as well as extra-intestinal, inflammation. Inflammatory conditions can induce formation of peroxynitrite (ONOO) and, thereby, endogenous protein nitration in the body. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357940PMC
January 2019
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The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood.

Expert Opin Drug Saf 2019 Feb 11. Epub 2019 Feb 11.

c Division of Surgery , University College London, Northwick Park Institute of Medical Research Campus , London , UK .

Introduction: The use of antibiotics prenatally, during pregnancy, or neonatally may have adverse effects on the neonatal gut microbiome, and adversely affect the development of the infant immune system, leading to the development of childhood atopy, asthma, allergy and obesity. Areas covered: We reviewed new evidence about vaginal eubiosis and dysbiosis from molecular-based, cultivation-independent techniques, and how this affects the neonatal gut microbiome and early development of the immune system in infants. We have considered the association between maternal use of antibiotics and the potentially beneficial role of vitamin D in the development of atopy, asthma, allergy and obesity. Read More

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http://dx.doi.org/10.1080/14740338.2019.1579795DOI Listing
February 2019

Eosinophil Peroxidase, GATA3 and T-bet as Tissue Biomarkers in Chronic Rhinosinusitis.

J Allergy Clin Immunol 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Mayo Clinic, Phoenix, AZ; Division of Allergy, Asthma, and Clinical Immunology, Mayo Clinic, Scottsdale, AZ; Division of Pulmonology, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Eosinophil peroxidase is a potential biomarker for eosinophilic chronic rhinosinusitis. Th2/Th1 polarization, as measured by GATA3 and T-bet, was not associated with eosinophilia or any clinical or histopathologic feature of chronic rhinosinusitis. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.038DOI Listing
February 2019
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Epigenetic age acceleration is associated with allergy and asthma in children in Project Viva.

J Allergy Clin Immunol 2019 Feb 6. Epub 2019 Feb 6.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: Epigenetic clocks have been suggested to capture one feature of the complexity between aging and the epigenome. However, little is known about the epigenetic clock in childhood allergy and asthma.

Objective: To examine associations of DNA methylation age (DNAmAge) and epigenetic age acceleration with childhood allergy and asthma. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.01.034DOI Listing
February 2019
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The nasal and skin microbiome are associated with disease severity in pediatric atopic dermatitis.

Br J Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Alterations of the skin microbiome have been associated with atopic dermatitis (AD) and its severity. The nasal microbiome in relation to AD severity is less well studied.

Objective: We aimed to characterize the nasal and skin microbiome in children with AD in relation to disease severity. Read More

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http://dx.doi.org/10.1111/bjd.17755DOI Listing
February 2019

Follow-up, 18 months off HDM immunotherapy, of a randomized controlled study on the primary prevention of atopy.

Allergy 2019 Feb 9. Epub 2019 Feb 9.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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http://dx.doi.org/10.1111/all.13744DOI Listing
February 2019
6.028 Impact Factor

A strategy for high-dimensional multivariable analysis classifies childhood asthma phenotypes from genetic, immunological and environmental factors.

Allergy 2019 Feb 9. Epub 2019 Feb 9.

Department of Pulmonary and Allergy, Dr. von Hauner Children's Hospital, LMU, Lindwurmstraße 4, 80337, Munich, Germany.

Background: Associations between childhood asthma phenotypes and genetic, immunological and environmental factors have been previously established. Yet, strategies to integrate high-dimensional risk factors from multiple distinct data sets, and thereby increase the statistical power of analyses, have been hampered by a preponderance of missing data and lack of methods to accommodate them.

Methods: We assembled questionnaire, diagnostic, genotype, microarray, RT-qPCR, flow cytometry and cytokine data (referred to as data modalities) to use as input factors for a classifier that could distinguish healthy children, mild-to-moderate allergic asthmatics and non-allergic asthmatics. Read More

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http://dx.doi.org/10.1111/all.13745DOI Listing
February 2019
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Endothelin-1 mediates Aspergillus fumigatus induced airway inflammation and remodelling.

Clin Exp Allergy 2019 Feb 8. Epub 2019 Feb 8.

Division of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, UK.

Background: Asthma is a chronic inflammatory condition of the airways and patients sensitised to airborne fungi such as Aspergillus fumigatus have more severe asthma. Thickening of the bronchial subepithelial layer is a contributing factor to asthma severity for which no current treatment exists. Airway epithelium acts as an initial defence barrier to inhaled spores, orchestrating an inflammatory response and contributing to subepithelial fibrosis. Read More

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http://dx.doi.org/10.1111/cea.13367DOI Listing
February 2019