148,841 results match your criteria Allergy Asthma & Clinical Immunology [Journal]


Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Immunology Section, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address:

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parint.2019.04.015DOI Listing

What did we learn from multiple omics studies in asthma?

Allergy 2019 Apr 20. Epub 2019 Apr 20.

Department of Respiratory Medicine, Amsterdam University Medical Centres, (AUMC), University of Amsterdam, Amsterdam, The Netherlands.

More than a decade has passed since the finalisation of the Human Genome Project. Omics technologies made a huge leap from trendy and very expensive to routinely executed and relatively cheap assays. Simultaneously, we understood that omics is not a panacea for every problem in the area of human health and personalized medicine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13833DOI Listing

Epitope mapping of antibodies induced with a conserved rhinovirus protein generating protective anti-rhinovirus immunity.

Vaccine 2019 Apr 16. Epub 2019 Apr 16.

Cellular and Molecular Immunology Research Centre, School of Human Sciences, London Metropolitan University, London, UK; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and chronic obstructive pulmonary disease (COPD) exacerbations. Currently there is no vaccine for RV which is largely due to the existence of ∼160 serotypes/strains. We demonstrated previously that immunising mice with highly conserved VP4 and VP2 regions of the RV polyprotein (RV-A16 VP0) generated cross-reactive immunity to RV in vivo. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0264410X193045
Publisher Site
http://dx.doi.org/10.1016/j.vaccine.2019.04.018DOI Listing
April 2019
1 Read

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 16. Epub 2019 Apr 16.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
2 Reads

B Cell Responses: Cell Interaction Dynamics and Decisions.

Cell 2019 Apr;177(3):524-540

Cardiovascular Research Institute, Department of Anatomy, and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

B cells and the antibodies they produce have a deeply penetrating influence on human physiology. Here, we review current understanding of how B cell responses are initiated; the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each path impacts antibody diversity, selectivity, and affinity. We discuss how basic research is informing efforts to generate vaccines that induce broadly neutralizing antibodies against viral pathogens, revealing the special features associated with allergen-reactive IgE responses and uncovering the antibody-independent mechanisms by which B cells contribute to health and disease. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674193027
Publisher Site
http://dx.doi.org/10.1016/j.cell.2019.03.016DOI Listing
April 2019
1 Read

Chronic cough and gastroesophageal reflux in children - CHEST Guideline and Expert Panel Report.

Chest 2019 Apr 16. Epub 2019 Apr 16.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA, USA.

Background: Whether gastroesophageal reflux (GER) or GER disease (GERD) causes chronic cough in children is controversial. Using the PICO format, we undertook 4 systematic reviews. For children with chronic cough (>4-weeks duration) and without underlying lung disease: (1) who do not have gastrointestinal GER symptoms, should empirical treatment for GERD be used? (2) with gastrointestinal GER symptoms, does treatment for GERD resolve the cough? (3) with or without gastrointestinal GER symptoms, what GER-based therapies should be used and for how long? (4) if GERD is suspected as the cause, what investigations and diagnostic criteria best determine GERD as the cause of the cough?

Methods: We used the CHEST Expert Cough Panel's protocol and American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00123692193083
Publisher Site
http://dx.doi.org/10.1016/j.chest.2019.03.035DOI Listing
April 2019
1 Read

Idiopathic anaphylaxis.

Clin Exp Allergy 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Immunology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Idiopathic anaphylaxis (IA) or spontaneous anaphylaxis is a diagnosis of exclusion when no cause can be identified. The exact incidence and prevalence of IA is not known. The clinical manifestations of IA are similar to other known causes of anaphylaxis. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13402
Publisher Site
http://dx.doi.org/10.1111/cea.13402DOI Listing
April 2019
1 Read

Predictors of reversible airway obstruction with omalizumab in severe asthma: a real-life study.

Ther Adv Respir Dis 2019 Jan-Dec;13:1753466619841274

Department of Medical Sciences, University of Turin, Corso Dogliotti 14 10126 Turin, Italy.

Background: Omalizumab may modulate airway remodeling in severe asthma. Using forced expiratory volume in 1 second (FEV) as a surrogate of airway remodeling, we aimed to investigate if an omalizumab add-on in severe allergic asthma may lead to a persistent reversal of airway obstruction and to evaluate the potential biomarkers of airway obstruction reversibility.

Methods: Data were collected before (T0) and after omalizumab add-on for 1 year (T1, 32 patients), 2 years (T2, 26 patients) and 4 years (T4, 13 patients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753466619841274DOI Listing

Bronchial Thermoplasty in Patients with Severe Uncontrolled Asthma: First Korean Cases.

J Korean Med Sci 2019 Apr 22;34(15):e120. Epub 2019 Apr 22.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Bronchial thermoplasty is a nonpharmacological treatment for severe asthma that delivers thermal energy to the bronchial walls and reduces hypertrophied smooth muscle mass. Previous studies have shown its efficacy and safety, resulting in approval from the Food and Drug Administration in 2010. In Korea, the first bronchial thermoplasty was carried out in 2014; 4 patients have undergone the procedure so far. Read More

View Article

Download full-text PDF

Source
https://jkms.org/DOIx.php?id=10.3346/jkms.2019.34.e120
Publisher Site
http://dx.doi.org/10.3346/jkms.2019.34.e120DOI Listing
April 2019
3 Reads

The Lowering of Bilirubin Levels in Full-Term Newborns by the Effect of Combined Massage Therapy and Phototherapy Practice.

Am J Perinatol 2019 Apr 18. Epub 2019 Apr 18.

Faculty of Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective:  Various therapeutic treatments have been prescribed for decreasing the bilirubin level. Massage therapy is one of the neonate treatments for jaundice. The aim of this study is to investigate the effects of combined massage therapy and phototherapy on neonatal jaundice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1685493DOI Listing
April 2019
1 Read

Multimorbidity in Asthma, Allergic Conditions and COPD Increase Disease Severity, Drug Use and Costs: The Finnish Pharmacy Survey.

Int Arch Allergy Immunol 2019 Apr 18:1-8. Epub 2019 Apr 18.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Background: Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known.

Objective: To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well as drug and healthcare costs.

Methods: Nationwide Allergy Barometer Survey was carried out in the Finnish pharmacies during 1 week in September 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498861DOI Listing
April 2019
1 Read

House Dust Mite-Induced Allergic Lung Inflammation Is Not Exacerbated in Sickle Cell Disease Mice.

Int Arch Allergy Immunol 2019 Apr 18:1-9. Epub 2019 Apr 18.

Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, USA,

Aim: Asthma appears to be a common comorbid condition in children with sickle cell disease (SCD), and such individuals may be at a higher risk for increased morbidity and mortality. However, several reports have indicated that asthma severity is not particularly high in those with SCD, and airway hyperreactivity and wheeze may be independently associated with SCD. In SCD mice, exacerbated allergic airway disease (AAD) has been observed in response to the model antigen ovalbumin (OVA). Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/499043
Publisher Site
http://dx.doi.org/10.1159/000499043DOI Listing
April 2019
2 Reads

IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
2 Reads

Does transbronchial lung cryobiopsy give useful information in asthmatic patients?

Multidiscip Respir Med 2019 8;14:12. Epub 2019 Apr 8.

Department of Thoracic Diseases, "GB. Morgagni" Hospital, Forlì, Italy.

Introduction: Lung biopsy in asthmatic patients is justified in case of atypical presentations of asthma, when other differential diagnoses, such as hypersensitivity pneumonitis or eosinophilic granulomatosis with polyangiitis, could be possible or for research purposes.

Aim: We aim to describe the utility and the safety of TBLC (transbronchial lung cryobiopsy) in asthmatic patients, providing data on the pathological changes occurring in the airways and in the lung parenchyma.

Methods: We reviewed asthmatic patients that underwent TBLC, that eventually had only a final diagnosis of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40248-019-0176-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452509PMC
April 2019
1 Read

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing
April 2019
1 Read

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
Publisher Site
http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
2 Reads
3.985 Impact Factor

IL-2 modulates Th2 cell responses to glucocorticosteroid: A cause of persistent type 2 inflammation?

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

Background: Glucocorticosteroids (GCs) are the main treatment for asthma as they reduce type 2 cytokine expression and induce apoptosis. Asthma severity is associated with type 2 inflammation, circulating Th2 cells and higher GC requirements.

Objective: The aim of this study was to assess whether ex vivo production of interleukin 2 (IL-2), a T-cell survival factor, associated with clinical features of asthma severity, the proportion of blood Th2 cells and Th2 cell responses to GC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/iid3.249DOI Listing
April 2019
1 Read

MEDITERRANEAN DIET AND ASTHMA: TIME FOR CLINICAL TRIALS IN CHILDREN.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):207-208

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; IMIB Bio-health Research Institute; and ARADyAL allergy network, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aller.2019.04.001DOI Listing
April 2019
1 Read

Direct assessment of skin epithelial barrier by electrical impedance spectroscopy.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.

Background: Many skin and mucosal inflammatory disorders, such as atopic dermatitis, have been associated with an impaired epithelial barrier function, which allows allergens, pollutants or microbes to enter the tissue and activate the immune response. The aim of this study was to establish a method to directly assess in vivo the epidermal barrier function by electrical impedance (EI) spectroscopy.

Methods: Mice epidermal barrier was damaged by epicutaneous application of proteases and cholera toxin and by tape stripping. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13824DOI Listing
April 2019
2 Reads

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

View Article

Download full-text PDF

Source
https://journals.squ.edu.om/index.php/squmj/article/view/299
Publisher Site
http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
2 Reads

Intranasal administration of (Cooke) Ryvarden (Tiger Milk mushroom) extract attenuates airway inflammation in murine model of allergic asthma.

Exp Ther Med 2019 May 20;17(5):3867-3876. Epub 2019 Mar 20.

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150 Malaysia.

Asthma is a chronic inflammatory disorder in the airways that involves the activation of cells and mediators. (Cooke) Ryvardan or Tiger Milk mushroom is a medicinal mushroom that is traditionally used to treat inflammatory diseases including asthma. In this study, the protective effects of intranasal administration of extract (LRE) in ovalbumin (OVA)-induced airway inflammation mouse model were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447947PMC

Omalizumab in patients with severe asthma and persistent sputum eosinophilia.

Allergy Asthma Clin Immunol 2019 3;15:21. Epub 2019 Apr 3.

1Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON Canada.

Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-019-0337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448265PMC
April 2019
2 Reads

Implications of prostaglandin D2 and leukotrienes in exhaled breath condensates of asthma.

Ann Allergy Asthma Immunol 2019 Apr 12. Epub 2019 Apr 12.

Department of Respiratory Medicine, Saitama Medical University, Iruma-gun, Saitama 350-0495, Japan; Allergy Center, Saitama Medical University Hospital, Iruma-gun, Saitama 350-0495, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.04.008DOI Listing

PTGDR expression is upregulated through retinoic acid receptors (RAR) mechanism in allergy.

PLoS One 2019 15;14(4):e0215086. Epub 2019 Apr 15.

Department of Biomedical and Diagnostic Sciences, University of Salamanca, Salamanca, Spain.

Functional studies suggest that promoter polymorphisms of the Prostaglandin D Receptor (PTGDR) gene can be involved in asthma. All-trans Retinoic acid (ATRA) has also been linked to allergic diseases. We have previously described the PTGDR promoter activation mediated by ATRA through response elements (RARE) at position -549T> C. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215086PLOS
April 2019
1 Read

Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school-aged children.

Pediatr Allergy Immunol 2019 Apr 15. Epub 2019 Apr 15.

Telethon Kids Institute, University of Western Australia, WA, Australia.

Background: Antigen specific IgE binds the Fcε receptor I (FcεRI) expressed on several types of immune cells, including dendritic cells (DC). Activation of FcεRI on DCs in atopics has been shown to modulate immune responses that potentially contribute to asthma development. However, the extent to which DC subsets differ in FcεRI expression between atopic children with or without asthma is currently not clear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13063DOI Listing

The Patient Needs in Asthma Treatment (NEAT) questionnaire: Further evidence on its psychometric properties.

Allergy 2019 Apr 15. Epub 2019 Apr 15.

Institute of Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Düsseldorf, Germany.

Background: Building on previous psychometric work, we sought to assess the Patient Needs in Asthma Treatment (NEAT) questionnaire's validity, responsiveness to change and the minimal important change (MIC) over a 3-year period (Study 1) and its reliability and the smallest detectable change (SDC) in a test-retest-study (Study 2) among patients self-reporting physician-diagnosed asthma.

Methods: In Study 1, a total of 207 patients completed a survey which included the NEAT, the Asthma Control Test (ACT), the Asthma Quality of Life Questionnaire-Sydney (AQLQ-S) and a question on treatment satisfaction in 2014 and 2017. In Study 2, a total of 78 patients completed NEAT twice on average four weeks apart in 2018. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13782
Publisher Site
http://dx.doi.org/10.1111/all.13782DOI Listing
April 2019
1 Read

Short-course administration of a traditional herbal mixture ameliorates asthma symptoms of the common cold in children.

Avicenna J Phytomed 2019 Mar-Apr;9(2):126-133

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Asthma is an increasing chronic respiratory disease affecting over 300 million people worldwide. Several studies have shown that herbal remedies may improve asthma control and reduce asthma symptoms. In this study, the effects of short-course administration of an herbal mixture (ASMATUS) in asthmatic children during viral respiratory tract infection, were evaluated. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448545PMC

IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

Clin Mol Allergy 2019 2;17. Epub 2019 Apr 2.

Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12948-019-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444864PMC
April 2019
1 Read

Prenatal vitamin D levels and child wheeze and asthma.

J Matern Fetal Neonatal Med 2019 Apr 14:1-241. Epub 2019 Apr 14.

b Division of General Pediatrics , Department of Pediatrics , Vanderbilt University Medical Center , Nashville , Tennessee , USA.

Background: Maternal vitamin D status during pregnancy may influence lung development and risk of childhood wheeze and asthma. We investigated the relationship between prenatal vitamin D and child asthma in a racially diverse cohort with a high burden of vitamin D insufficiency and child asthma.

Methods: We included mother-child dyads in the prenatal Conditions Affecting neurocognitive Development and Learning in Early Childhood (CANDLE) cohort (2006-2011, Shelby County, Tennessee). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
Publisher Site
http://dx.doi.org/10.1080/14767058.2019.1607286DOI Listing
April 2019
4 Reads

Evaluating fluticasone furoate + vilanterol for the treatment of chronic obstructive pulmonary disease (COPD).

Expert Opin Pharmacother 2019 Apr 14:1-11. Epub 2019 Apr 14.

a Pulmonary, Critical Care, Allergy and Sleep Medicine , Medical University of South Carolina , Charleston , SC , USA.

Introduction: Inhaled corticosteroid/long-acting β-2 agonists (ICS/LABA) combination inhalers have been a lifeline for a generation of chronic obstructive pulmonary disease (COPD) and asthma patients. Fluticasone furoate and Vilanterol (FF/VI) as a once-daily ICS/LABA combination have an extensive clinical trial and real-world data to support its use in COPD patients. Areas covered: The authors provide pharmacological profiles of fluticasone furoate, vilanterol and the FF/VI fixed dose combination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1603292DOI Listing
April 2019
2 Reads

Favorable clinical efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma: a 48-week pilot study.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Department of Allergy and Respiratory Medicine, Sutoh Hospital, Annaka, Gunma, Japan.

Summary: Assessing efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma patients. This study was a 48-week prospective open-label analysis of mepolizumab in 11 asthmatics with chronic rhinosinusitis (CRS). It was administered every 4 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23822/EurAnnACI.1764-1489.94DOI Listing

Frequency of allergic sensitization to Can f 5 in North East Italy. An analysis of 1403 ISACs 112 (Component Resolved Diagnosis) collected retrospectively.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Postgraduate School of Respiratory Medicine. Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Summary: Recent studies have shown the increasing relevance of allergic sensitization to Can f 5, a prostatic kallicrein expressed in the prostate and detectable only in male dogs. The aim of the present study was to establish the frequency, level of sensitization and association with other dog allergens of Can f 5, as assessed by Component Resolved Diagnosis (CRD- ISAC 112, ThermoFisher Scientific, Uppsala, Sweden), in North East Italy. A total of 1403 CRD ISAC 112 were examined retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23822/EurAnnACI.1764-1489.89DOI Listing
April 2019
1 Read

Chronicity of Mental Comorbidity in Children with New-onset Physical Illness.

Child Care Health Dev 2019 Apr 14. Epub 2019 Apr 14.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Background: Evidence suggests that physical and mental illness are strongly correlated in children. This study examined patterns of the chronicity of multimorbidity (co-occurring physical and mental illness); estimated homotypic continuity; and, modelled factors associated with chronicity in children newly diagnosed with a chronic physical illness.

Methods: Children aged 6-16 years diagnosed with one of asthma, diabetes, epilepsy, food allergy, or juvenile arthritis were recruited from two children's hospitals and followed for six months. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cch.12667
Publisher Site
http://dx.doi.org/10.1111/cch.12667DOI Listing
April 2019
2 Reads

Contemporary analysis of otolaryngic allergy.

Laryngoscope 2019 Apr 14. Epub 2019 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, UNC Neuroscience Hospital, Chapel Hill, North Carolina, U.S.A.

Objectives: Investigate the current trends in otolaryngic allergy (OA).

Study Design: Cross-sectional survey.

Methods: Survey of active AAOA membership. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.28002DOI Listing
April 2019
1 Read

Benzo(a)pyrene Facilitates Dermatophagoides Group 1 (Der f 1)-Induced Epithelial Cytokine Release through Aryl Hydrocarbon Receptor in Asthma.

Allergy 2019 Apr 14. Epub 2019 Apr 14.

The Affiliated Luohu Hospital of Shenzhen University, Shenzhen, Luohu Hospital Group, Shenzhen, China.

Background: Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co-exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1-induced asthma and its underlying mechanisms. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13784
Publisher Site
http://dx.doi.org/10.1111/all.13784DOI Listing
April 2019
8 Reads

Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):772S-799S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations.

Objectives: The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma.

Methods: The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcn/nqy283DOI Listing
March 2019
1 Read
6.770 Impact Factor

Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review.

Am J Clin Nutr 2019 Mar;109(Supplement_7):890S-934S

USDA, Food and Nutrition Service, Alexandria, VA.

Background: Nutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.

Objectives: The aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?

Methods: The literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcn/nqy220DOI Listing
March 2019
3 Reads
6.770 Impact Factor

A case of Mycobacterium tuberculosis laboratory cross-contamination.

J Infect Chemother 2019 Apr 11. Epub 2019 Apr 11.

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan; Department of Basic Mycobacteriology, Graduate School of Biomedical Science, Nagasaki University, Japan. Electronic address:

Setting: A laboratory cross-contamination event was suspected because Mycobacterium tuberculosis was unexpectedly detected at a high incidence in the cultures of several clinical specimens at the National Hospital Organization, Tokyo National Hospital, Japan.

Objective: To describe a case of Mycobacterium tuberculosis laboratory cross-contamination.

Design: We reviewed the medical records of 20 patients whose clinical specimens were suspected to have been contaminated by Mycobacterium tuberculosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1341321X193007
Publisher Site
http://dx.doi.org/10.1016/j.jiac.2019.03.012DOI Listing
April 2019
1 Read

DNA methylation and a biomarker panel to predict asthma development.

Authors:
Harald Renz

J Allergy Clin Immunol 2019 Apr 11. Epub 2019 Apr 11.

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps Universität Marburg, German Center for Lung Research (DZL) Marburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.04.002DOI Listing

Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

J Affect Disord 2019 Apr 9;252:60-67. Epub 2019 Apr 9.

Tsaotun Psychiatric Center, Ministry of Health and Welfare, 542 No.161, Yu-Pin Rd, Caotun Township, Nantou, Taiwan, R.O.C.. Electronic address:

Background: Studies have reported an association between allergy and panic disorder. However, few studies have explored the relationship between allergic rhinitis and panic disorder. Previous studies were limited by cross-sectional study designs, self-reported symptoms, absence of matched controls, and lack of consideration of the influence of steroid and comorbidities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.04.037DOI Listing
April 2019
1 Read

Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma.

Environ Int 2019 Apr 10;127:503-513. Epub 2019 Apr 10.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, USA.

Background: Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations.

Objectives: To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma.

Methods: We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2019.04.003DOI Listing
April 2019
1 Read

The alpha-melanocyte-stimulating hormone acts as a local immune homeostasis factor in experimental allergic asthma.

Clin Exp Allergy 2019 Apr 12. Epub 2019 Apr 12.

Division of Asthma -Exacerbation& -Regulation, Priority Area Asthma & Allergy, Research Center Borstel- Leibniz Lung Center, Borstel, Germany.

Background: Originally, the neuropeptide α-melanocyte-stimulating hormone (α-MSH) has been described as a mediator of skin pigmentation. However, recent studies have shown that α-MSH is able to modulate inflammation in various tissues including the lung. So far, it is still not clear, whether α-MSH also plays a role in allergic bronchial asthma. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/cea.13400
Publisher Site
http://dx.doi.org/10.1111/cea.13400DOI Listing
April 2019
5 Reads

Analysis of allergens in corn-dependent exercise-induced anaphylaxis.

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Fujita Health University General Allergy Center, Nagoya, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.04.005DOI Listing
April 2019
1 Read

Peanut-Allergic Patient Experiences After Epicutaneous Immunotherapy: Peanut Consumption and Impact on QoL.

Ann Allergy Asthma Immunol 2019 Apr 9. Epub 2019 Apr 9.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.04.006DOI Listing

Allergy to Mus m 1: Allergy to Mus m 1: A review of structural, and immunological features.

Immunol Lett 2019 Apr 9;209:1-3. Epub 2019 Apr 9.

Medical Research Group (GINUMED) Universitary Corporation Rafael Nuñez, Colombia.

The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478193005
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2019.03.012DOI Listing
April 2019
2 Reads

Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-Exacerbated Respiratory Disease: A Prospective Trial.

Am J Respir Crit Care Med 2019 Apr 12. Epub 2019 Apr 12.

Brigham and Women's Hospital Department of Medicine, 370908, Division of Rheumatology, Immunology, and Allergy, Boston, Massachusetts, United States.

Rationale: Daily high-dose aspirin therapy benefits many patients with aspirin-exacerbated respiratory disease but provides no benefit for aspirin-tolerant asthmatics. Type 2 inflammation characterizes aspirin-exacerbated respiratory disease.

Objective: We sought to determine whether high-dose aspirin therapy changes biomarkers of type 2 inflammation in aspirin-exacerbated respiratory disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201809-1755OCDOI Listing

Prevalence of food hypersensitivity in relation to IgE sensitisation to common food allergens among the general adult population in West Sweden.

Clin Transl Allergy 2019 1;9:22. Epub 2019 Apr 1.

2Department of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: The prevalence of self-experienced adverse reactions to foods seems to have an increasing trend in both adults and children. However, it is unclear if the prevalence of food hypersensitivity in the Swedish adult population is still rising, what symptoms are caused by different foods and which are the most common foods to which adults are more frequently IgE-sensitised.

Methods: In a cross-sectional study based on questionnaire responses, interviews and clinical examinations as part of the West Sweden Asthma Study, 1042 subjects from the general population, 17-78 years of age, living in Västra Götaland, Sweden, were included. Read More

View Article

Download full-text PDF

Source
https://ctajournal.biomedcentral.com/articles/10.1186/s13601
Publisher Site
http://dx.doi.org/10.1186/s13601-019-0261-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442429PMC
April 2019
2 Reads

Prevalence of food allergy among schoolchildren in Kuwait and its association with the coexistence and severity of asthma, rhinitis, and eczema: A cross-sectional study.

Authors:
Ali H Ziyab

World Allergy Organ J 2019 30;12(4):100024. Epub 2019 Mar 30.

Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Background: Food allergy (FA) is a common public health problem that affects both children and adults. Empirical knowledge of the burden of FA in Kuwait is limited. This study sought to estimate the prevalence of FA among schoolchildren in Kuwait and assess associations between FA and the coexistence and severity of asthma, rhinitis, and eczema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.waojou.2019.100024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441753PMC
March 2019
1 Read

Variability in total serum IgE over 1 year in severe asthmatics.

Allergy Asthma Clin Immunol 2019 29;15:20. Epub 2019 Mar 29.

6Novartis Pharma, Medialaan 40, 1800 Vilvoorde, Belgium.

Background: Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgE) in asthmatics remains poorly documented.

Methods: In this prospective study, sIgE levels were measured over 1 year at 7 time points in 41 severe asthmatics treated with high-dose of inhaled corticosteroids and long-acting β agonists. Read More

View Article

Download full-text PDF

Source
https://aacijournal.biomedcentral.com/articles/10.1186/s1322
Publisher Site
http://dx.doi.org/10.1186/s13223-019-0331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441212PMC
March 2019
2 Reads