532,263 results match your criteria Allergy Asthma & Immunology Research[Journal]

Resveratrol attenuates mast cell mediated allergic reactions: potential for use as a nutraceutical in allergic diseases?

Mol Nutr Food Res 2022 May 22:e2200170. Epub 2022 May 22.

Institute of Nutritional Medicine, University of Hohenheim, 70599, Stuttgart, Germany.

Allergic diseases are one of the most common health disorders affecting about 30% of the world population. Mast cells (MCs) are key effector cells of allergic reactions by releasing proinflammatory mediators including histamine, lipid mediators and cytokines/chemokines. Natural substances like secondary plant substances such as resveratrol (RESV), which can contribute to prevention and treatment of diseases, are becoming increasingly interesting for use as nutraceuticals. Read More

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Examining the impact of multilevel upper airway surgery on the obstructive sleep apnoea endotypes and their utility in predicting surgical outcomes.

Respirology 2022 May 21. Epub 2022 May 21.

Department of Physiology, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria.

Background And Objective: Upper airway surgery for obstructive sleep apnoea (OSA) is an alternative treatment for patients who are intolerant of continuous positive airway pressure (CPAP). However, upper airway surgery has variable treatment efficacy with no reliable predictors of response. While we now know that there are several endotypes contributing to OSA (i. Read More

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The new era of add-on asthma treatments: where do we stand?

Allergy Asthma Clin Immunol 2022 May 21;18(1):42. Epub 2022 May 21.

Division of Pulmonary, Critical Care, and Sleep Medicine, Yale Center for Asthma and Airway Disease, Yale University School of Medicine, New Haven, CT, USA.

Globally, a small proportion (5-12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative for Asthma (GINA) management committee recommends treating patients with asthma with inhaled corticosteroids plus long-acting β-agonists and, when needed, adding a long-acting muscarinic receptor antagonist or biologic agent. Read More

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P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.

Retrovirology 2022 May 21;19(1). Epub 2022 May 21.

Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada.

Background: P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P-selectin. Recently, PSGL-1 was identified as a novel HIV-1 host restriction factor, particularly when expressed at high levels in the HIV envelope. Importantly, while the potent antiviral activity of PSGL-1 has been clearly demonstrated in various complementary model systems, the breadth of PSGL-1 incorporation across genetically diverse viral isolates and clinical isolates has yet to be described. Read More

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Identification of excretory and secretory proteins from Haemonchus contortus inducing a Th9 immune response in goats.

Vet Res 2022 May 21;53(1):36. Epub 2022 May 21.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.

Th9 cells have been shown to play crucial roles in anti-parasite immunity, pathogenic microbe infection, and allergy. Previous studies have demonstrated that Haemonchus contortus excretory and secretory proteins (HcESPs) induce the proliferation of Th9 cells and alter the transcriptional level of IL-9 as well as its related pathways in the Th9 immune response after infection. However, the exact molecule(s) in HcESPs inducing the Th9 immune response is not yet known. Read More

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Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.

Nutr Metab (Lond) 2022 May 21;19(1):37. Epub 2022 May 21.

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Background: Adiposity and mitochondrial dysfunction are related factors contributing to metabolic disease development. This pilot study examined whether in vivo and ex vivo indices of mitochondrial metabolism were differentially associated with body composition in males and females.

Methods: Thirty-four participants including 19 females (mean 27 yr) and 15 males (mean 29 yr) had body composition assessed by dual energy x-ray absorptiometry and magnetic resonance (MR) imaging. Read More

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Complex and unexpected outcomes of antibiotic therapy against a polymicrobial infection.

ISME J 2022 May 21. Epub 2022 May 21.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA.

Antibiotics are our primary approach to treating complex infections, yet we have a poor understanding of how these drugs affect microbial communities. To better understand antimicrobial effects on host-associated microbial communities we treated cultured sputum microbiomes from people with cystic fibrosis (pwCF, n = 24) with 11 different antibiotics, supported by theoretical and mathematical modeling-based predictions in a mucus-plugged bronchiole microcosm. Treatment outcomes we identified in vitro that were predicted in silico were: 1) community death, 2) community resistance, 3) pathogen killing, and 4) fermenter killing. Read More

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Mode of Birth Is Not Associated With Food Allergy Risk in Infants.

J Allergy Clin Immunol Pract 2022 Apr 30. Epub 2022 Apr 30.

Population Health, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. Electronic address:

Background: The association between mode of delivery and the risk of food allergy remains unclear due to the absence of studies with both challenge-proven food allergy outcomes and detailed information on the type of caesarean delivery.

Objective: We assessed whether emergency or elective caesarean, or caesarean delivery in the presence or absence of labor initiation, is associated with the risk of food allergy.

Methods: The HealthNuts study recruited 5276 12-month-old infants who underwent skin prick testing and oral food challenge to ascertain food allergy status, and linked the child's study data to additional birth data from the Victorian Perinatal Data Collection. Read More

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The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study.

J Allergy Clin Immunol 2022 May 10. Epub 2022 May 10.

Murdoch Children's Research Institute, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.

Background: Prospectively collected data on the natural history of food allergy are lacking.

Objective: We examined the natural history of egg and peanut allergy in children from age 1 to 6 years and assessed whether a skin prick test (SPT) result or other clinical factors at diagnosis are associated with the persistence or resolution of food allergy in early childhood.

Methods: The HealthNuts cohort consists of 5276 children who were recruited at age 1 year and have been followed prospectively. Read More

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Incorporating tryptase genotyping into the workup and diagnosis of mast cell diseases and reactions.

J Allergy Clin Immunol Pract 2022 May 18. Epub 2022 May 18.

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

The measurement of mast cell tryptase levels in serum has found utility in the diagnosis and management of both clonal mast cell disorders and severe mast cell-dependent systemic reactions in the form of anaphylaxis. A more recent discovery is that a majority of individuals with elevated basal serum tryptase (BST) levels have increased germline TPSAB1 gene copy number encoding α-tryptase. This genetic trait is referred to as hereditary alpha-tryptasemia (HαT) and affects nearly 6% of the general population. Read More

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Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults.

J Allergy Clin Immunol 2022 May 18. Epub 2022 May 18.

University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Background: Asthma disproportionately affects African-American/Black (AA/B) and Hispanic/Latinx (H/L) patients and individuals with low socioeconomic status (SES), but the relationship between SES and asthma morbidity within these racial/ethnic groups is inadequately understood.

Objective: To determine the relationship between SES and asthma morbidity among AA/B and H/L adults with moderate-severe asthma using multi-domain SES frameworks and mediation analyses.

Methods: We analyzed enrollment data from the PREPARE randomized trial, evaluating inhaled corticosteroid supplementation to rescue therapy. Read More

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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism.

Dev Cell 2022 May 15. Epub 2022 May 15.

National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

The changes that drive differentiation facilitate the emergence of abnormal cells that need to be removed before they contribute to further development or the germline. Consequently, in mice in the lead-up to gastrulation, ∼35% of embryonic cells are eliminated. This elimination is caused by hypersensitivity to apoptosis, but how it is regulated is poorly understood. Read More

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Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue.

Clin Rev Allergy Immunol 2022 May 21. Epub 2022 May 21.

Rheumatology Clinic, Università Politecnica Delle Marche, Carlo Urbani" Hospital, Via Aldo Moro, 25, 60035, Jesi, Ancona, Italy.

Frailty is a new concept in rheumatology that can help identify people more likely to have less favorable outcomes. Sarcopenia and inflammaging can be regarded as the biological foundations of physical frailty. Frailty is becoming more widely accepted as an indicator of ageing and is linked to an increased risk of negative outcomes such as falls, injuries, and mortality. Read More

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[Assessment of the state of the small intestine microbiota in children on a long-term dairy-free diet].

Vopr Pitan 2022 14;91(2):15-20. Epub 2022 Mar 14.

M. Gorky Donetsk National Medical University, 283003, Donetsk, Donetsk People's Republic.

An overview of recent outcomes of studies indicates an imbalance in the diet of children. Quantitative and qualitative malnutrition of children is the basis of a number of childhood diseases. of the research was to study the prevalence of small intestine bacterial overgrowth syndrome (SIBO) in children on a long-term dairy-free diet. Read More

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Histopathological characteristics are instrumental to distinguish monomorphic from polymorphic maculopapular cutaneous mastocytosis in children.

Clin Exp Dermatol 2022 May 20. Epub 2022 May 20.

Department of pathology, Erasmus University MC, Rotterdam, The Netherlands.

Background: Mastocytosis is characterized by the accumulation of mast cells (MC) in skin or other organs and can manifest at all ages. The majority of pediatric mastocytosis cases persist after puberty. In particular, monomorphic maculopapular cutaneous mastocytosis (mMPCM) is often persistent and associated with systemic mastocytosis. Read More

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Nasal Nitric Oxide May Not Differentiate Primary Ciliary Dyskinesia from Certain Primary Immunodeficiencies.

Pediatr Pulmonol 2022 May 20. Epub 2022 May 20.

Division of Pediatric Pulmonary, Allergy and Sleep Medicine. Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana.

The diagnosis of primary ciliary dyskinesia (PCD) is made through a combination of clinical features supported by a panel of diagnostic tests. Our cases highlight the similarities in the clinical presentation of patients with the specific immunodeficiency activated phosphatidylinositol 3-kinase delta syndrome 1 (APDS1 or PIK3CD-Related Disorder) and PCD. We highlight the importance of repeating nasal nitric oxide testing (nNO) when PCD has not been confirmed by genetic or ciliary electron micrograph (EM) analysis in the setting of an expanded suppurative lung disease differential that includes considerations for immunodeficiency as well as PCD. Read More

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Rituximab-induced serum sickness in a girl with nephrotic syndrome.

CEN Case Rep 2022 May 20. Epub 2022 May 20.

Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

Rituximab (RTX) has been used to treat B cell lineage lymphoma/leukemia or autoimmune or autoinflammatory disorders. RTX therapy has been extensively applied to cases of frequently relapsing nephrotic syndrome (FRNS) and steroid-dependent nephrotic syndrome. Rituximab-induced serum sickness (RISS) has been recognized as a rare severe type-3 hypersensitivity reaction in patients treated with RTX. Read More

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Alpha-1 Asthma Overlap Syndrome: a Clinical Overview.

Curr Allergy Asthma Rep 2022 May 20. Epub 2022 May 20.

Department of Internal Medicine, Section On Pulmonary, Critical Care, Immunologic, and Asthma Medicine, Wake Forest Baptist Hospital, 1 Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Purpose Of Review: Alpha-1 antitrypsin deficiency (AATD) is one of the most common genetic diseases that is associated with severe complications and yet remains underdiagnosed. The pulmonary symptoms of both AATD and asthma include cough, excessive sputum production, dyspnea, and wheezing. These symptoms overlap significantly leading to difficulty distinguishing between these two conditions and suspicion that there may be an overlap syndrome. Read More

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Improvements to Survey Design from Pilot Testing a Discrete-Choice Experiment of the Preferences of Persons Living with HIV for Long-Acting Antiretroviral Therapies.

Patient 2022 May 21. Epub 2022 May 21.

The Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, WA, USA.

Background And Objective: Development of clear and effective discrete-choice experiment surveys is an important step toward ensuring accurate and usable preference results. Pretest interviews and pilot testing are common in the development of discrete-choice experiments, and it is important for researchers to report details of survey changes resulting from patient feedback elicited in pilot work. This paper details pilot testing of an online discrete-choice experiment to elicit preferences for long-acting antiretroviral therapies among patients with HIV. Read More

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The Dynamic Role of Cardiac Macrophages in Aging and Disease.

Curr Cardiol Rep 2022 May 20. Epub 2022 May 20.

Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Washington University School of Medicine, 660 South Euclid Campus, Box 8086, St. Louis, MT, 63110, USA.

Purpose Of Review: The cardiac immune landscape dynamically changes in response to aging, hemodynamic stress, and myocardial injury. Here, we highlight key cardiac immune cell types, their role in reshaping the cellular landscape and promoting tissue remodeling following cardiac insults, and how understanding of these processes uncovers novel disease mechanisms that contribute to cardiac pathology.

Recent Findings: Distinct subsets of cardiac macrophages reside within the heart and exhibit divergent functions in response to myocardial injury. Read More

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Anaphylactic reaction to carboplatin diagnosed by skin testing-a reliable tool in platinum-based immediate-type hypersensitivity reactions.

Wien Med Wochenschr 2022 May 20. Epub 2022 May 20.

Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Immediate-type hypersensitivity reactions (IHRs) to carboplatin (CA) are most commonly reported in ovarian cancer patients. A 54-year-old woman with stage IV melanoma suffering from metastasis in the entire right lower extremity was presented to our allergy outpatient clinic for diagnostic work-up due to an anaphylactic reaction with palmoplantar erythema, conjunctivitis along with facial erythema, and an incipient decrease in blood pressure during a chemotherapy regimen with dacarbazine and carboplatin upon re-administration. A subsequently carried out allergological work-up with skin testing (ST) revealed CA to be the culprit drug, whereas cisplatin (CI) was confirmed to be a safe alternative for the patient for following treatments. Read More

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Building digital twins of the human immune system: toward a roadmap.

NPJ Digit Med 2022 May 20;5(1):64. Epub 2022 May 20.

Biocomplexity Institute and Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.

Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control. Personalized computational models are also assisting in applications ranging from drug development to treatment optimization. More advanced medical digital twins will be essential to making precision medicine a reality. Read More

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Immune globulin therapy and kidney disease: Overview and screening, monitoring, and management recommendations.

Am J Health Syst Pharm 2022 May 20. Epub 2022 May 20.

KabaFusion, Cerritos, CA, USA.

Disclaimer: In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Read More

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The Science of Context: Transforming Serious Illness Care Though In Situ Observation.

J Pain Symptom Manage 2022 Jun;63(6):e651-e653

Department of Surgery (M.L.S), Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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Surrogates of Patients With Severe Acute Brain Injury Experience Persistent Anxiety and Depression Over the 6 Months After ICU Admission.

J Pain Symptom Manage 2022 Jun;63(6):e633-e639

Division of Pulmonary Diseases and Critical Care Medicine (B.W., A.C., S.S.C.), University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Context: Severe Acute Brain Injury (SABI) is neurologically devastating, and surrogates for these patients may struggle with particularly complex decisions due to substantial prognostic uncertainty.

Objectives: To compare anxiety and depression symptoms over time between SABI surrogates and non-SABI surrogates for patients requiring prolonged mechanical ventilation (PMV).

Methods: We conducted a secondary analysis of the data from a multicenter randomized trial of a decision aid intervention for surrogates of adults experiencing PMV. Read More

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ProPACC: Protocol for a Trial of Integrated Specialty Palliative Care for Critically Ill Older Adults.

J Pain Symptom Manage 2022 Jun;63(6):e601-e610

Program on Ethics and Decision Making, The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine (S.K.A., G.V., R.A.B., E.H.P.B., D.M., S.K., R.O., J.S., D.B.W.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Palliative Research Center (PaRC) (R.A.B., J.R., K.B.B., A.T., L.A.K., J.S., R.A., Y.S., D.B.W.), University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

Background: Each year, approximately one million older adults die in American intensive care units (ICUs) or survive with significant functional impairment. Inadequate symptom management, surrogates' psychological distress and inappropriate healthcare use are major concerns. Pioneering work by Dr. Read More

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To J.R.C. with L.O.V.E.

J Pain Symptom Manage 2022 Jun;63(6):e577-e578

Palliative and Advanced Illness Research (PAIR) Center, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Department of Medical Ethics and Health Policy (S.D.H.),University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA.

Immunohorizons 2022 May 20;6(5):299-306. Epub 2022 May 20.

Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA;

RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid-sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Read More

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