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Allergy Asthma Proc 2022 05;43(3):234-242

Division of Immunology and Allergic Diseases, Department of Chest Diseases, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Compared with advances in a drug hypersensitivity diagnosis and management, little is known about the mental health status of patients with drug hypersensitivity and the impact of this psychological distress on their quality of life (QoL). The objectives were to evaluate anxiety, depression, and QoL levels in patients with drug hypersensitivity, assess how some related factors may affect them, and determine the impact of disease on their QoL. A total of 203 patients with drug hypersensitivity and 80 healthy controls were evaluated with the Beck Anxiety (BAI) and the Depression Inventory (BDI), and the short version of the World Health Organization Quality of Life (WHOQOL-BREF) scale. Read More

Allergy Asthma Proc 2022 05;43(3):175-177

Allergy Asthma Proc 2022 05;43(3):243

Allergy Asthma Proc 2022 05;43(3):187-193

Department of Pediatrics, Georgetown University Medical Center, Washington D.C.

Long COVID (coronavirus disease 2019) syndrome includes a group of patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit lingering mild-to-moderate symptoms and develop medical complications that can have lasting health problems. In this report, we propose a model for the pathophysiology of the long COVID presentation based on increased proinflammatory cytokine production that results from the persistence of the SARS-CoV-2 virus or one of its molecular components. Associated with this hyperproduction of inflammatory cytokines is a heightened activity of nuclear factor κ B (NF-κB) and p38 mitogen-activated protein kinase signaling pathways that regulate cytokine production. Read More

Allergy Asthma Proc 2022 05;43(3):202-208

Global Clinical Scientist Lead, Clinical Research TA Immunology, CSL Behring, King of Prussia, Pennsylvania.

Hereditary angioedema (HAE) due to C1-inhibitor (C1-INH) deficiency is a rare genetic disorder characterized by disabling episodes of edema that commonly affect the skin as well as the gastrointestinal tract and upper airway. Prophylactic therapy can decrease the severity and number of attacks. Long-term symptom control and rescue medication use were evaluated in patients with HAE who received subcutaneous (SC) C1-INH enrolled in an open-label extension (OLE) of the phase III COMPACT (Clinical Studies for Optimal Management of Preventing Angioedema with Low-Volume Subcutaneous C1-Inhibitor Replacement Therapy) trial, including a subgroup analysis of patients treated for ≥12 months. Read More

Allergy Asthma Proc 2022 05;43(3):178-186

Department of Medicine, Monmouth Medical Center, Rutgers Robert Wood Johnson Medical Center, Long Branch, New Jersey.

Eosinophilic esophagitis (EoE) is a Type-2 chronic inflammatory food antigen-driven disease of the esophagus, characterized by eosinophilic predominant inflammation and a constellation of symptoms. The incidence and prevalence of EoE has increased over the past 2 decades. There is an unmet need for approved less burdensome treatment options. Read More

Allergy Asthma Proc 2022 05;43(3):226-233

From the Division of Allergy and Immunology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Peanut component tests (PCT) have become important in the evaluation of peanut allergy. There remains a paucity of research across the United States in investigating the utility of PCT in clinical practice in conjunction with current standards of care. The primary aims were to evaluate the performance and sensitization patterns of PCT in clinical practice when first available at our institution. Read More

Allergy Asthma Proc 2022 05;43(3):194-201

Allergy and Asthma Network, Vienna, Virginia.

Telehealth use increased during the coronavirus disease 2019 (COVID-19) pandemic to provide patient care while deferring to social distancing recommendations. Health-care provider and patient surveys were conducted to assess the impact of COVID-19 on the use and perception of telehealth visits for atopic and respiratory diseases. Health-care provider (N = 200) and patient (N = 200) surveys were conducted in the United States between September and October, 2020, and January, 2021. Read More

Allergy Asthma Proc 2022 05;43(3):220-225

From the Division of Allergy and Immunology, Department of Chest Diseases, Hacettepe University School of Medicine, Ankara, Turkey.

Pollen hypersensitivity might be a determining factor for other nonseasonal allergens because it may indicate deviation of the immune system toward T-helper type 2 activity and immunoglobulin E sensitivity. To investigate whether timothy grass pollen allergy may be a predictive factor for cat sensitization and whether there is an association between sensitivity to both allergens. A retrospective review was made of patients with symptoms of rhinitis. Read More

Allergy Asthma Proc 2022 05;43(3):209-219

From the Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, China.

Cough is often the most prominent and intractable symptom reported by patients with asthma, but few studies have explored the characteristics of patients with asthma and with chronic cough (CC) in a real-world setting. In a prospective cohort study, patients ages ≥ 18 years with stable asthma were consecutively recruited at the West China Hospital, Sichuan University. The patients were classified as having asthma with CC (the CC group) or asthma with non-CC (the non-CC group) after 3 months of optimized asthma therapy according to standard guidelines. Read More

Allergy Asthma Proc 2022 Mar;43(2):174

Allergy Asthma Proc 2022 03;43(2):173

Allergy Asthma Proc 2022 03;43(2):168-172

Department of Medicine (Division of Allergy/Immunology), Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania; and.

Oral challenges and desensitizations are regularly performed by allergy/immunology physicians. However, there is limited research that has evaluated their cost-effectiveness and overall health-care-related value. The objective was to analyze the costs of oral challenges and desensitizations by clinician type (including allergy/immunology physicians, other physicians, and certified registered nurse practitioners [CRNP] and physician assistants [PA]), and by geographic distribution in the United States. Read More

Allergy Asthma Proc 2022 03;43(2):163-167

Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota.

Penicillin is the most common reported drug allergy. Previous literature suggests that there is increased prevalence of penicillin drug allergy in female patients in the outpatient setting. However, this is poorly described in the inpatient setting. Read More

Allergy Asthma Proc 2022 03;43(2):155-162

From the Univ. Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France.

A differential diagnosis between angiotensin-converting enzyme inhibitor (ACEi) angioedema (AE) and histaminergic AE (hAE) might be challenging. Follow-up data may help discriminate these conditions but are scarcely reported. To report on the follow-up of patients with suspected ACEi-AE and to describe the baseline characteristics of AE attacks in patients with a diagnosis of ACEi-AE after follow-up. Read More

Allergy Asthma Proc 2022 03;43(2):148-154

Patients' satisfaction is important for the success of the management of chronic diseases. Our aim was to evaluate the satisfaction level of the patients with hereditary angioedema (HAE) for icatibant treatment. Patients with HAE C1 esterase inhibitor (C1-INH) were evaluated by using a questionnaire that included details of their icatibant-treated attacks. Read More

Allergy Asthma Proc 2022 03;43(2):140-147

Division of Allergy and Clinical Immunology, Department of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey; and.

It is known that socioeconomic factors affect various chronic diseases and also might affect asthma control. Exposure to housecleaning products has been shown to impact both the onset and control of asthma. This study aimed to determine the effect of socioeconomic factors and house cleaning on asthma control of women with asthma. Read More

Allergy Asthma Proc 2022 03;43(2):133-139

From the Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Asthma is a heterogeneous disease, characterized by chronic airway inflammation. Asthma exacerbations (AE) are episodes characterized by a progressive increase in symptoms of shortness of breath, cough, wheezing, or chest tightness with a decrease in lung function. There have been previous studies that examined the role of eosinophil-derived neurotoxin (EDN) in asthma, but there have been no studies of the role of EDN in children experiencing AE. Read More

Allergy Asthma Proc 2022 03;43(2):124-132

From the National Respiratory Medical Center, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; and.

Immunoglobulin E (IgE) plays an important role in asthma, but a few patients exhibit extremely high levels of serum total IgE. This study aimed to investigate the profiles of comorbidity and/or complications, severity, and sensitizations in patients with asthma and with a total IgE level > 1000 kU/L. We retrospectively analyzed 170 patients with asthma and with total IgE levels of >1000 kU/L from the inpatient data base. Read More

Allergy Asthma Proc 2022 03;43(2):116-123

Oak and birch pollens are strongly cross-reactive. It is unknown how robust this cross-reactivity is in patients without natural exposure to pollen of both trees. We assessed the symptom response to birch pollen in subjects with skin-prick test (SPT) results positive to oak and birch but only naturally exposed to oak by using an allergen challenge chamber. Read More

Allergy Asthma Proc 2022 03;43(2):106-115

From the Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

The clinical effects of intranasal corticosteroids (INC) on nasal symptoms and the clinical course of coronavirus disease 2019 (COVID-19) in subjects with chronic rhinitis (CR) seem unclear. To evaluate the clinical effects of INCs on nasal symptoms in subjects with CR and with COVID-19. In subjects with CR and diagnosed with COVID-19 at four tertiary centers, quality of life and nasal symptoms were assessed by using the 22-item Sino-Nasal Outcome Test (SNOT-22) and the visual analog scale (VAS), respectively. Read More

Allergy Asthma Proc 2022 03;43(2):96-105

Department of Otolaryngology - Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia.

The coronavirus disease 2019 (COVID-19) pandemic has been associated with a dramatic increase in postviral olfactory dysfunction (PVOD) among patients who are infected. A contemporary evidence-based review of current treatment options for PVOD is both timely and relevant to improve patient care. This review seeks to impact patient care by qualitatively reviewing available evidence in support of medical and procedural treatment options for PVOD. Read More

Allergy Asthma Proc 2022 03;43(2):93-95

Allergy Asthma Proc 2022 01;43(1):e17-e24

From the Pediatric Respiratory Unit, University Hospital of Patras, University of Patras Medical School, Rion, Patras, Greece; and.

The prevalence of childhood asthma, rhinoconjunctivitis, and eczema in the city of Patras, Greece, has been followed in four consecutive surveys since 1991. After a continuous rise in the prevalence of all three of these disorders, a plateau was reached for asthma between 2003 and 2008, whereas the prevalence of rhinoconjunctivitis and eczema continued to increase. To investigate these trends in the same population into the following decade. Read More

Allergy Asthma Proc 2022 01;43(1):e11-e16

From the Department of Internal Medicine, Medstar Union Memorial Hospital, Baltimore, Maryland.

The Asthma Control Test (ACT) is a commonly used scoring system for evaluation of asthma control in the pediatric and adult populations. Asthma control has been deemed poor in those economically disadvantaged. To study whether the ACT is affected by socioeconomic status (SES) as evaluated by the percentage of the federal poverty level and the education level. Read More

Allergy Asthma Proc 2022 Jan;43(1):e1-e10

School of Economic, Political, and Policy Sciences, the University of Texas at Dallas, Richardson, Texas.

The coronavirus disease 2019 (COVID-19) pandemic has greatly affected health-care provision across the globe. Management of chronic ailments has become challenging because of the strained health-care resources and social distancing measures that prevent on-site clinical visits and treatments. Hereditary angioedema (HAE) is a debilitating, chronic disease characterized by unpredictable swelling attacks in various parts of the body. Read More

Allergy Asthma Proc 2022 Jan;43(1):86-90

Allergy Asthma Proc 2022 01;43(1):85

Allergy Asthma Proc 2022 01;43(1):78-84

Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.

Eosinophilic esophagitis is a complex disease with an increasing prevalence. Multidisciplinary teams are often needed to manage this difficult-to-treat condition. To observe the clinical and histologic outcomes of patients with eosinophilic esophagitis after management in a multidisciplinary clinic. Read More

Allergy Asthma Proc 2022 01;43(1):64-69

From the Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; and.

Most patients who report penicillin allergy are found to tolerate penicillin later in life. Few studies have examined patients' understanding and beliefs about penicillin allergy and testing. Evaluating patients' perspectives may help identify ways to improve patient education and increase testing to de-label those who can tolerate penicillin. Read More