488,550 results match your criteria Allergy & Rhinology [Journal]


Interleukin 12-23 Deficiency in the Interferon Gamma Pathway in a 6-Month-Old Toddler Who has BCG Vaccine Complications.

Dermatol Ther 2020 Jul 11:e13999. Epub 2020 Jul 11.

Laboratory of Human Genetics of Infectious Diseases, Institut National De La Santé Et De La Recherche Médicale, Paris, France.

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http://dx.doi.org/10.1111/dth.13999DOI Listing

IL17RA variations showed no associations with post-bronchiolitis asthma or lung function.

Pediatr Int 2020 Jul 12. Epub 2020 Jul 12.

Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.

Background: Interleukin-17A (IL-17A) and IL-17F are involved with pathogenesis of asthma and allergy. Interleukin-17 receptor A (IL-17RA), encoded by the IL17RA gene, is a common receptor for IL-17A and IL-17F. The aim of the present study was to evaluate the association of IL17RA gene variations with asthma, allergy and lung function at school age in children prospectively followed-up after hospitalization for bronchiolitis in early infancy. Read More

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http://dx.doi.org/10.1111/ped.14387DOI Listing

LPAR2 receptor activation attenuates radiation-induced disruption of apical junctional complexes and mucosal barrier dysfunction in mouse colon.

FASEB J 2020 Jul 12. Epub 2020 Jul 12.

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on γ-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC cell monolayers in vitro and mice in vivo. Mice were subjected to either total body irradiation (TBI) or partial body irradiation (PBI-BM5). Read More

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http://dx.doi.org/10.1096/fj.202000544RDOI Listing

Positive patch testing with omeprazole in Stevens-Johnson syndrome: a case report.

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life threatening cutaneous reactions, caused by a delayed-type hypersensitivity reaction to medication1. Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide with a large proportion of non-evidence based applications2. A 69-year-old man, known with arterial hypertension and gout, was started on 64mg methylprednisolone for a chronic inflammatory demyelinating polyneuropathy. Read More

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http://dx.doi.org/10.1111/jdv.16814DOI Listing

Incorporating Patient and Caregiver Feedback into Lung Transplant Referral Guidelines for Individuals with Cystic Fibrosis - Preliminary Findings from a Novel Paradigm.

Clin Transplant 2020 Jul 12:e14038. Epub 2020 Jul 12.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

Background: Lung transplantation is a common therapeutic option for individuals with cystic fibrosis (CF) and advanced lung disease, yet many individuals with CF are not appropriately referred for evaluation. The present study sought to enhance CF transplant referral guidelines by integrating patient-centered input to identify possible psychosocial barriers contributing to suboptimal referral for appropriate CF transplant candidates.

Methods: As a component of developing the Cystic Fibrosis Foundation (CFF) Lung Transplant Referral Consensus Guidelines, we convened a focus group of lung transplant recipients with CF and two spouses of CF recipients. Read More

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http://dx.doi.org/10.1111/ctr.14038DOI Listing

Protocol to prevent contrast-induced nephropathy in parenteral challenge-tests for allergy evaluation of hypersensitivity reactions to iodinated contrast media.

Clin Exp Allergy 2020 Jul 11. Epub 2020 Jul 11.

Department of Allergy, Hospital Universitario de la Princesa, Instituto de Investigacion Sanitaria Princesa (IP), Madrid, Spain.

Acute renal damage is the most frequent toxic reaction induced by parenteral administration of iodinated contrast media (ICM), leading to a condition named contrast-induced nephropathy (CIN). This pathology was described by Bartels et al. in 1954 and, in most cases, it is transient and does not imply any relevant modifications of renal function. Read More

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http://dx.doi.org/10.1111/cea.13709DOI Listing

The neighbourhood natural environment is associated with asthma in children: a birth cohort study.

Allergy 2020 Jul 12. Epub 2020 Jul 12.

EPIUnit, Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.

Background: A lower exposure to the natural environment has been hypothesized to adversely affect the human microbiome and its immunomodulatory capacity. However,the underlying effects of this hypothesis are stillnot understood. We aimed to evaluate the effect of early-life exposure to greenness and species richness on the development of allergic diseases and asthma in children. Read More

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http://dx.doi.org/10.1111/all.14493DOI Listing

Allergic contact dermatitis in podiatrists handling resin insoles: a report of two cases.

Contact Dermatitis 2020 Jul 12. Epub 2020 Jul 12.

Department of Allergology, Centre Erik Satie, Rouen University Hospital, Rouen, France.

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http://dx.doi.org/10.1111/cod.13655DOI Listing

Comprehensive flow cytometric reference intervals of leukocyte subsets from six study centers across Europe.

Clin Exp Immunol 2020 Jul 12. Epub 2020 Jul 12.

Institute of Immunology, Heidelberg University Hospital, German Center for Infection Research (DZIF), partner site Heidelberg, Heidelberg, Germany.

A group of European FOCIS Centers of Excellence adapted panels of the Human Immunophenotyping Consortium (HIPC) for whole blood analysis. Using 4 core panels (T/Treg/B/NK and myeloid cells) the main leukocyte populations were analyzed in a clinical-diagnostic setting in a harmonized way across different platforms. As a first step, the consortium presents here the absolute and relative frequencies of the leukocyte subpopulations in the peripheral blood of more than 300 healthy volunteers across 6 different European centers. Read More

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http://dx.doi.org/10.1111/cei.13491DOI Listing

Otitis Media and Inborn Errors of Immunity.

Curr Allergy Asthma Rep 2020 Jul 11;20(10):59. Epub 2020 Jul 11.

Clinical Immunology, Reference Center for Rare Diseases, Faculdade de Medicina, Centro Universitario Saude ABC, Avenida Lauro Gomes, 2000, Santo Andre, SP, 09060-870, Brazil.

Purpose Of Review: The aim of this review is as follows: (1) to present the role of otitis as a warning sign for inborn errors of immunity (IEI), (2) to establish which patients presenting otitis should be investigated for IEI, (3) to review data about main IEI associated with otitis-prone patients.

Recent Findings: Otitis media is a very common infection in general population. The concept of otitis-prone children established a certain frequency of the infections in order to look for conditions leading to them. Read More

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http://dx.doi.org/10.1007/s11882-020-00957-xDOI Listing

As soon as possible in IgE-cow's milk allergy immunotherapy.

Eur J Pediatr 2020 Jul 11. Epub 2020 Jul 11.

Pediatric Allergy Unit, Miguel Servet University Hospital, Paseo Isabel La Católica 1-3, 50009, Zaragoza, Spain.

Oral immunotherapy is a common treatment in cow's milk protein allergy. The Department of Pediatric Allergology at the Children's Hospital of Zaragoza performed a retrospective analysis of 335 infants under 1 year of age diagnosed with IgE-mediated cow's milk and early treated. Clinical evaluation, skin prick test, and serum-specific IgE level control were performed before starting and after finishing treatment. Read More

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http://dx.doi.org/10.1007/s00431-020-03731-3DOI Listing

Adolescents living with food allergies in select global cities: Does a WhatsApp-based mindful eating intervention promote wellbeing and enhance their self-concept?

Authors:
Samta P Pandya

J Pediatr Nurs 2020 Jul 9;55:83-94. Epub 2020 Jul 9.

Tata Institute of Social Sciences, Sion-Trombay Road, Deonar, Mumbai 400088, Maharashtra, India. Electronic address:

Purpose: Food allergy prevalence in children and adolescents is increasing globally. Dietary restrictions are linked to the identities of food-allergic adolescents, which influences their wellbeing and self-concept. Mindful eating (ME) has been widely used to treat eating disorders. Read More

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http://dx.doi.org/10.1016/j.pedn.2020.06.014DOI Listing

Compositional and immunogenic evaluation of fractionated wheat beers using mass spectrometry.

Food Chem 2020 Jul 5;333:127379. Epub 2020 Jul 5.

Food Allergy Research and Resource Program, Department of Food Science and Technology, Food Innovation Center, 1901 North 21st Street, University of Nebraska-Lincoln, Lincoln, NE 68588, United States. Electronic address:

The safety and regulatory status of fermented products derived from gluten-containing grains for patients with celiac disease remains controversial. Bottom-up mass spectrometry (MS) has complemented immunoassays for the compositional and immunogenic analyses of wheat beers. However, uncharacterized proteolysis during brewing followed by the secondary digestion for MS has made the analysis and data interpretation complicated. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127379DOI Listing

Telehealth: the future is now in allergy practice.

J Allergy Clin Immunol Pract 2020 Jul 9. Epub 2020 Jul 9.

Allergy Centre, CUF Descobertas Hospital, Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.jaip.2020.06.044DOI Listing

OCCUPATIONAL RHINITIS.

J Allergy Clin Immunol Pract 2020 Jul 9. Epub 2020 Jul 9.

Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

There is convincing evidence that tight relationships between the upper and lower airways also apply to the workplace context. The majority of patients with occupational asthma (OA) also suffer from ocupational rhinitis (OR), although OR is 2 to 3 times more common than occupational asthma (OA). OR most often precedes the development of OA, especially when high-molecular-weight protein agents are involved, and longitudinal cohort studies have confirmed that OR is associated with an increased risk for the development of OA. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.06.047DOI Listing

Busulfan Pharmacokinetics in ADA SCID Gene Therapy.

Biol Blood Marrow Transplant 2020 Jul 9. Epub 2020 Jul 9.

Department of Pediatric Hematology-Oncology, University of California, Los Angeles (UCLA); Department of Microbiology, Immunology and Molecular Genetics, UCLA; Department of Molecular & Medical Pharmacology, UCLA; The Eli & Edythe Broad Stem Cell Research Center, UCLA. Electronic address:

The pharmacokinetics of low dose busulfan (BU) were investigated as a non-myeloablative conditioning regimen for autologous gene therapy (GT) in pediatric subjects with adenosine deaminase-deficient severe combined immunodeficiency (ADA SCID). In three successive clinical trials, which included either γ-retroviral (γ-RV) or lentiviral (LV) vectors, subjects were conditioned with BU using different dosing nomograms; the first cohort received BU doses based on body surface area (BSA), the second based on actual body weight (ABW), and the third utilized therapeutic drug monitoring (TDM) to target a specific area under the concentration-time curve (AUC). Neither BSA nor ABW-based dosing achieved consistent cumulative BU AUC; in contrast, use of TDM-based dosing led to more consistent AUC. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.07.004DOI Listing

The Relationship between Diabetes Mellitus and COVID-19 Prognosis: A Retrospective Cohort Study in Wuhan, China.

Am J Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. of China; The Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan 430071, P.R. of China. Electronic address:

Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease, first appeared in Wuhan, China, and quickly spread throughout the world. We aimed to understand the relationship between diabetes mellitus and the prognosis of COVID-19.

Methods: Demographic, clinical, laboratory, radiologic, treatments, complications, and clinical outcomes data were extracted from electronic medical records and compared between diabetes (n=84) and non-diabetes (n=500) groups. Read More

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http://dx.doi.org/10.1016/j.amjmed.2020.05.033DOI Listing

Chronic stress and asthma in adolescents.

Ann Allergy Asthma Immunol 2020 Jul 9. Epub 2020 Jul 9.

Division of Pulmonary Medicine, Department of Pediatrics, UPMC Children's Hospital. Electronic address:

Objective: To first review and critically discuss published evidence on psychosocial stressors, stress, and asthma in adolescents, and then discuss potential future directions in this field.

Data Sources: National Library of Medicine (Pubmed).

Study Selections: A literature search was conducted for human studies on stressors or stress and asthma between 2000 and 2020. Read More

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http://dx.doi.org/10.1016/j.anai.2020.07.001DOI Listing

Intravenous Cetirizine Versus Intravenous Diphenhydramine for the Treatment of Acute Urticaria: A Phase III Randomized Controlled Noninferiority Trial.

Ann Emerg Med 2020 Jul 8. Epub 2020 Jul 8.

TerSera Therapeutics, Deerfield, IL.

Study Objective: Acute urticaria is a frequent presentation in emergency departments (EDs), urgent care centers, and other clinical arenas. Treatment options are limited if diphenhydramine is the only intravenous antihistamine offered because of its short duration of action and well-known adverse effects. We evaluate cetirizine injection, the first second-generation injectable antihistamine, for acute urticaria in this multicenter, randomized, noninferiority, phase 3 clinical trial. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2020.05.025DOI Listing

Hymenoptera venom allergy among children in Italy: time for pediatricians to take action.

Allergol Immunopathol (Madr) 2020 Jul 8. Epub 2020 Jul 8.

Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

Hymenoptera venom allergy (HVA) is one of the most frequent causes of anaphylaxis following a bee, vespid or ant sting. Real-life data regarding the management of HVA in children are lacking. To address this unmet need, we carried out a survey defining the current management of HVA in children among pediatric allergists in Italy. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.003DOI Listing

Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.

Allergol Immunopathol (Madr) 2020 Jul 8. Epub 2020 Jul 8.

Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Objectives: Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children's Medical Center.

Patients: The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2019.07.012DOI Listing

Studies on relationships between air pollutants and allergenicity of Humulus Scandens pollen collected from different areas of Shanghai.

J Environ Sci (China) 2020 Sep 30;95:43-48. Epub 2020 Apr 30.

School of Science and Engineering, Saitama University, Saitama 338-8570, Japan.

Pollen pollution and allergy are becoming prominent issues in China. However, few studies on pollinosis have been reported. As an allergen in the atmosphere, allergenic Humulus scandens pollen was collected from four districts of Shanghai, including Wusong (WS), Jiading (JD), Xujiahui (XJH) and Songjiang (SJ). Read More

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http://dx.doi.org/10.1016/j.jes.2020.03.037DOI Listing
September 2020

Nedaplatin use in patients with hypersensitivity reaction episodes to carboplatin.

Taiwan J Obstet Gynecol 2020 Jul;59(4):546-550

Department of Obstetrics and Gynecology, Jichi Medical University, Saitama Medical Center, Japan.

Objective: To evaluate the benefits of nedaplatin treatment in patients with a history of hypersensitivity reactions to carboplatin.

Materials And Methods: We retrospectively reviewed the medical records of patients with ovarian, fallopian, and peritoneal cancers and with a history of hypersensitivity to carboplatin between January 2010 and December 2016 at the Department of Gynecology in the Saitama Medical Center associated with Jichi Medical University. We studied the response rate to treatment with a nedaplatin-based regimen compared to that of a carboplatin regimen. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.05.013DOI Listing

Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.

Lancet Respir Med 2020 Jul 9. Epub 2020 Jul 9.

Novartis Pharmaceuticals, East Hanover, NJ, USA.

Background: Patients with asthma who are inadequately controlled on inhaled corticosteroid-long-acting β-adrenoceptor agonist (ICS-LABA) combinations might benefit from the addition of a long-acting muscarinic receptor antagonist. The aim of the IRIDIUM study was to assess the efficacy and safety of a once-daily, single-inhaler combination of mometasone furoate, indacaterol acetate, and glycopyrronium bromide (MF-IND-GLY) versus ICS-LABA in patients with inadequately controlled asthma.

Methods: In this 52-week, double-blind, double-dummy, parallel-group, active-controlled phase 3 study, patients were recruited from 415 sites across 41 countries. Read More

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http://dx.doi.org/10.1016/S2213-2600(20)30190-9DOI Listing

Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study.

Environ Health Prev Med 2020 Jul 11;25(1):28. Epub 2020 Jul 11.

Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan.

Background: Sick building syndrome (SBS) refers to the combination of symptoms experienced by occupants of specific building characteristics. This study investigated the associations of children's lifestyle behaviors, allergies, home, and school environment with SBS symptoms.

Methods: A total of 4408 elementary school children living in Sapporo City, Japan participated in this study. Read More

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http://dx.doi.org/10.1186/s12199-020-00869-2DOI Listing

Review of Indoor Aerosol Generation, Transport and Control in the Context of COVID-19.

Int Forum Allergy Rhinol 2020 Jul 11. Epub 2020 Jul 11.

Department of Civil, Architectural, and Environmental Engineering, College of Engineering, Drexel University, Philadelphia, PA, USA.

The coronavirus disease 2019 (COVID-19) pandemic has heightened awareness of aerosol generation by human expiratory events and their potential role in viral respiratory disease transmission. Concerns over high Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral burden of mucosal surfaces has raised questions about the aerosol generating potential and dangers of many otorhinolaryngologic procedures. However, the risks of aerosol generation and associated viral transmission by droplet or airborne routes for many otorhinolaryngology procedures are largely unknown. Read More

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http://dx.doi.org/10.1002/alr.22661DOI Listing

Hypertension burden and challenges across the hypertension treatment cascade among adults enrolled in HIV care in northern Tanzania.

J Clin Hypertens (Greenwich) 2020 Jul 11. Epub 2020 Jul 11.

Duke Global Health Institute, Duke University, Durham, NC, USA.

Failure to address hypertension among people living with HIV (PLWH) may undermine the significant progress made toward reducing mortality among this high-risk population in sub-Saharan Africa (SSA). Here, the authors report hypertension prevalence, diagnosis, and treatment among patients enrolled in HIV care in Tanzania. Patients attending an HIV clinic were consecutively screened for hypertension. Read More

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http://dx.doi.org/10.1111/jch.13929DOI Listing

The impact of antibiotic allergy testing in transplant patients.

Transpl Infect Dis 2020 Jul 11:e13411. Epub 2020 Jul 11.

Department of Infectious Diseases and Centre for Antibiotic Allergy and Research, Austin Health,, VIC, Australia.

Patient reported antibiotic allergies, so-called antibiotic allergy labels (AAL) are highly prevalent amongst hospitalized patients globally . The highest prevalence of AALs has been found to be in immunocompromised patients, in particular transplant patients, with a large U.S. Read More

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http://dx.doi.org/10.1111/tid.13411DOI Listing

Delayed type III hypersensitivity reaction with acute kidney injury in two dogs following administration of concentrated human albumin during treatment for hypoalbuminemia secondary to septic peritonitis.

J Vet Emerg Crit Care (San Antonio) 2020 Jul 11. Epub 2020 Jul 11.

International Veterinary Renal Pathology Service, Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.

Objective: To describe 2 dogs with acute kidney injury secondary to type III hypersensitivity reaction to 25% human serum albumin (HSA).

Case Series Summary: Two dogs were presented with evidence of septic peritonitis. The dogs were hospitalized following definitive surgical correction of a jejunal laceration following routine ovariohysterectomy, and removal of a jejunal foreign body. Read More

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http://dx.doi.org/10.1111/vec.12976DOI Listing

High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease.

Mov Disord 2020 Jul 11. Epub 2020 Jul 11.

Institute of Clinical Pharmacology, Goethe-University, Medical Faculty, Frankfurt, Germany.

Background: Parkinson's disease (PD) causes chronic pain in two-thirds of patients, in part originating from sensory neuropathies. The aim of the present study was to describe the phenotype of PD-associated sensory neuropathy and to evaluate its associations with lipid allostasis, the latter motivated by recent genetic studies associating mutations of glucocerebrosidase with PD onset and severity. Glucocerebrosidase catalyzes the metabolism of glucosylceramides. Read More

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http://dx.doi.org/10.1002/mds.28186DOI Listing

Corrigendum.

Authors:

Allergy 2020 Jul;75(7):1837

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http://dx.doi.org/10.1111/all.14230DOI Listing

Detection of peanut allergens in serum: circumventing the inhibitory effect of immunoglobulins.

Allergy 2020 Jul;75(7):1835-1836

Nutritional Biology, Department of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.

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http://dx.doi.org/10.1111/all.14330DOI Listing

In This Issue: Graphical Abstracts.

Authors:

Allergy 2020 Jul;75(7):1537-1542

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http://dx.doi.org/10.1111/all.13900DOI Listing

Bcl-3 inhibits lupus-like phenotypes in BL6/lpr mice.

Eur J Immunol 2020 Jul 11. Epub 2020 Jul 11.

Laboratory of Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Bcl-3 is an atypical member of the IκB family that modulates NF-κB activity in nuclei. lpr mice carry the lpr mutation in Fas, resulting in functional loss of this death receptor; they serve as models for lupus erythematosus and ALPS. To explore the biologic roles of Bcl-3 in this disease model we generated BL6/lpr mice lacking Bcl-3. Read More

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http://dx.doi.org/10.1002/eji.202048584DOI Listing

Childhood allergy is preceded by an absence of gut lactobacilli species and higher levels of atopy-related plasma chemokines.

Clin Exp Immunol 2020 Jul 11. Epub 2020 Jul 11.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

Alterations in the composition and reduced diversity of the infant microbiome are associated with allergic disease in children. Further, an altered microbiota is linked to immune dysregulation, including skewing of different T-helper (Th)-subsets, which is also seen in atopic individuals. The aim of this study was therefore to investigate the associations between gut lactobacilli and Th-related plasma factors in allergy-development during childhood. Read More

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http://dx.doi.org/10.1111/cei.13494DOI Listing

Right ventricular stroke distance predicts death and clinical deterioration in patients with pulmonary embolism.

Thromb Res 2020 Jul 3;195:29-34. Epub 2020 Jul 3.

Division of Cardiology, Department of Medicine, New York University School of Medicine, 530 First Ave. Skirball 9R, New York, NY 10016, United States of America.

Purpose: The right ventricular outflow tract (RVOT) velocity time integral (VTI), an echocardiographic measure of stroke distance, correlates with cardiac index. We sought to determine the prognostic significance of low RVOT VTI on clinical outcomes among patients with acute pulmonary embolism (PE).

Materials And Methods: We conducted a retrospective review of echocardiograms on Pulmonary Embolism Response Team (PERT) activations at our institution. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.06.049DOI Listing

Rapid recovery of a SARS-CoV-2 infected X-linked agammaglobulinemia patient after infusion of COVID-19 convalescent plasma.

J Allergy Clin Immunol Pract 2020 Jul 8. Epub 2020 Jul 8.

Inmunología y Alergología, Hospital Universitario Reina Sofía, Avda Menéndez Pidal S/N. 14004 Córdoba, Spain; Unidad de Inmunología Facultad de Medicina. Universidad de Córdoba. Avda Menéndez Pidal S/N. 14004 Córdoba, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.06.046DOI Listing

Oscillometry for Acute Asthma in the Pediatric Emergency Department: A Feasibility Study.

Ann Allergy Asthma Immunol 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Pulmonary and Sleep Medicine, Children's Hospital Colorado, University of Colorado School of Medicine.

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http://dx.doi.org/10.1016/j.anai.2020.07.002DOI Listing

Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts.

Cell Host Microbe 2020 Jul 3. Epub 2020 Jul 3.

Department of Immunology and Genomics, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan; Division of Metagenome Medicine, Human Genome Center, the Institute of Medical Sciences, the University of Tokyo, Tokyo 108-8639, Japan; Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, the Institute of Medical Sciences, the University of Tokyo, Tokyo 108-8639, Japan; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo 113-8657, Japan. Electronic address:

The application of bacteriophages (phages) is proposed as a highly specific therapy for intestinal pathobiont elimination. However, the infectious associations between phages and bacteria in the human intestine, which is essential information for the development of phage therapies, have yet to be fully elucidated. Here, we report the intestinal viral microbiomes (viromes), together with bacterial microbiomes (bacteriomes), in 101 healthy Japanese individuals. Read More

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http://dx.doi.org/10.1016/j.chom.2020.06.005DOI Listing

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-Induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies.

Curr Drug Metab 2020 Jul 11. Epub 2020 Jul 11.

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow. Poland.

Background: Painful peripheral neuropathy is a dose-limiting adverse effect of the antitumor drug oxaliplatin. The main symptoms of neuropathy: tactile allodynia and cold hyperalgesia, appear in more than 80% of patients on oxaliplatin therapy and are due to the overexpression of neuronal sodium channels (Navs) and neuroinflammation.

Objective: This study assessed antiallodynic and antihyperalgesic properties of two repurposed drugs with antiinflammatory and Nav-blocking properties (bromhexine and its pharmacologically active metabolite - ambroxol) in a mouse model of neuropathic pain induced by oxaliplatin. Read More

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http://dx.doi.org/10.2174/1389200221666200711155632DOI Listing

The precious fluorine on the ring: fluorine NMR for biological systems.

J Biomol NMR 2020 Jul 10. Epub 2020 Jul 10.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA.

The fluorine-19 nucleus was recognized early to harbor exceptional properties for NMR spectroscopy. With 100% natural abundance, a high gyromagnetic ratio (83% sensitivity compared to H), a chemical shift that is extremely sensitive to its surroundings and near total absence in biological systems, it was destined to become a favored NMR probe, decorating small and large molecules. However, after early excitement, where uptake of fluorinated aromatic amino acids was explored in a series of animal studies, F-NMR lost popularity, especially in large molecular weight systems, due to chemical shift anisotropy (CSA) induced line broadening at high magnetic fields. Read More

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http://dx.doi.org/10.1007/s10858-020-00331-zDOI Listing

Non-acid Reflux: When It Matters and Approach to Management.

Curr Gastroenterol Rep 2020 Jul 10;22(9):43. Epub 2020 Jul 10.

Stanford Multidimensional Program for Innovation and Research in the Esophagus (S-MPIRE), Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway Street, Pavilion C, 3rd Floor, GI suite, Redwood City, CA, 94063, USA.

Purpose Of Review: This narrative review focuses on the presentation, contributing factors, diagnosis, and treatment of non-acid reflux. We also propose algorithms for diagnosis and treatment.

Recent Findings: There is a paucity of recent data regarding non-acid reflux. Read More

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http://dx.doi.org/10.1007/s11894-020-00780-4DOI Listing

Reflux Hypersensitivity: How to Approach Diagnosis and Management.

Curr Gastroenterol Rep 2020 Jul 10;22(9):42. Epub 2020 Jul 10.

Division of Gastroenterology, Stanford University, 420 Broadway Street, Pavilion D, Redwood City, CA, 94063, USA.

Purpose Of Review: This paper aims to review the definition and diagnostic criteria for reflux hypersensitivity and comment on the present and future management of this condition.

Recent Findings: In 2016, the Rome IV criteria redefined reflux hypersensitivity as characterized by typical reflux symptoms, absence of endoscopic mucosal disease, absence of pathologic gastroesophageal reflux, and positive symptom correlation between reflux and heartburn episodes. Though uncertain, TPRV1 receptors have been implicated in the pathophysiology of reflux hypersensitivity. Read More

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http://dx.doi.org/10.1007/s11894-020-00779-xDOI Listing

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.

Nat Med 2020 Jul 10. Epub 2020 Jul 10.

Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Antibodies are a principal determinant of immunity for most RNA viruses and have promise to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 has caused a global pandemic with millions of infections and hundreds of thousands of deaths to date. In response, we used a rapid antibody discovery platform to isolate hundreds of human monoclonal antibodies (mAbs) against the SARS-CoV-2 spike (S) protein. Read More

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http://dx.doi.org/10.1038/s41591-020-0998-xDOI Listing

Spiropiperidyl rifabutins: expanded in vitro testing against ESKAPE pathogens and select bacterial biofilms.

J Antibiot (Tokyo) 2020 Jul 10. Epub 2020 Jul 10.

Center for Drug Discovery and Innovation, University of South Florida, Tampa, FL, USA.

The expanded microbiological evaluation of a series of rifastures, novel spiropiperidyl rifamycin derivatives, against clinically relevant ESKAPE bacteria has identified several analogs with promising in vitro bioactivities against antibiotic-resistant strains of Enterococcus faecium and Staphylococcus aureus. Thirteen of the rifastures displayed minimum inhibitory concentrations (MICs) below 1 µg/ml against the methicillin- and vancomycin-resistant forms of S. aureus and E. Read More

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http://dx.doi.org/10.1038/s41429-020-0346-xDOI Listing

A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing.

Nat Commun 2020 Jul 10;11(1):3461. Epub 2020 Jul 10.

Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993, USA.

Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa transmitted by infected sand flies. Vaccination through leishmanization with live Leishmania major has been used successfully but is no longer practiced because it resulted in occasional skin lesions. A second generation leishmanization is described here using a CRISPR genome edited L. Read More

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http://dx.doi.org/10.1038/s41467-020-17154-zDOI Listing

Human inborn errors of immunity: An expanding universe.

Sci Immunol 2020 Jul;5(49)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Molecular, cellular, and clinical studies of human inborn errors of immunity have revolutionized our understanding of their pathogenesis, considerably broadened their spectrum of immunological and clinical phenotypes, and enabled successful targeted therapeutic interventions. These studies have also been of great scientific merit, challenging a number of immunological notions initially established in inbred mice while revealing previously unrecognized mechanisms of host defense by leukocytes and other cells and of both innate and adaptive tolerance to self. Read More

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http://dx.doi.org/10.1126/sciimmunol.abb1662DOI Listing

Oncoplastic Repair in Breast Conservation: Comprehensive Evaluation of Techniques and Oncologic Outcomes of 937 Patients.

Clin Breast Cancer 2020 Jun 7. Epub 2020 Jun 7.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

Background: Breast-conserving surgery, especially with oncoplastic breast surgery (OBS), is becoming the standard of care in the surgical management of breast cancer. We investigated the applied technique of OBS and oncologic outcomes in a large series of patients.

Patients And Methods: This study was conducted between January 2008 and June 2018 in two centers in Iran. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.05.016DOI Listing

Effect of Transcatheter Aortic Valve Implantation on the Immune Response Associated With Surgical Aortic Valve Replacement.

Am J Cardiol 2020 Aug 14;128:35-44. Epub 2020 May 14.

Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

The immune response after transcatheter aortic valve implantation (TAVI) in comparison to that after surgical aortic valve replacement (SAVR) remains to be fully elucidated. In a 2-part study, we assessed laboratory data obtained before, immediately after, and 24 and 48 hours after SAVR (128 patients; age ≥80 [mean 82] years) or transfemoral TAVI (102 patients; age ≥80 [mean 86] years) performed for aortic stenosis. In-hospital mortalities were similar (3% vs 0%), but leukocyte counts and aspartate aminotransferase and creatine kinas concentrations were decreased immediately and 24 hours after surgery (all, p <0. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.037DOI Listing