456,499 results match your criteria Allergy & Rhinology [Journal]


CytoML for cross-platform cytometry data sharing.

Cytometry A 2018 Dec;93(12):1189-1196

Program in Biostatistics Bioinformatics and Epidemiology, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Western Australia.

CytoML is an R/Bioconductor package that enables cross-platform import, export, and sharing of gated cytometry data. It currently supports Cytobank, FlowJo, Diva, and R, allowing users to import gated cytometry data from commercial platforms into R. Once data are available in R, the data can be further manipulated. Read More

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December 2018

Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.

Pharmacol Rep 2018 Oct 6;71(1):139-148. Epub 2018 Oct 6.

Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland. Electronic address:

Background: The G protein-coupled receptor 35 (GPR35), is considered important for nociceptive transmission, as suggested by accumulating evidence. This receptor was discovered in 1998; however, a lack of pharmacological tools prevented a complete understanding of its function and how to exploit it therapeutically. We studied the influence of CXCL17, kynurenic acid and zaprinast on nociceptive transmission in naïve and neuropathic mice. Read More

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October 2018

Sex-Specific Association between Prenatal Life Stress Exposure and Infant Pro-Inflammatory Cytokine Levels during Acute Respiratory Infection.

Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, 37232-2650, USA.

Background: Prenatal life stress exposure is linked to dysregulated immune function and chronic inflammatory disease in offspring, but we know little about its effects on infant immune response during viral infection.

Method: To address this issue, we examined associations between prenatal life stress exposure and infant upper-airway inflammatory markers during acute respiratory infection (ARI) using data from a prospective, population-based birth-cohort study (N=180). Infant inflammation was measured as a continuous latent factor within a structural equation modeling framework using nasal wash concentrations of interleukin-1β, interleukin-6, and tumor necrosis factor-α. Read More

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December 2018

The role of the skin microbiome in atopic dermatitis.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, University of California, San Diego, CA,. Electronic address:

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December 2018
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The Asthma Controller Step-down Yardstick.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Kaiser Permanente Southern California Region, Department of Allergy and Research and Evaluation, San Diego and Pasadena, CA.

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December 2018

Development of a Health-Related Quality of Life (QoL) instrument for Patients with Hereditary Angioedema (HAE) living in the United States.

J Allergy Clin Immunol Pract 2018 Dec 11. Epub 2018 Dec 11.

Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA.

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December 2018

Vernal Keratoconjunctivitis.

Surv Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. The main pathogenic mechanism is IgE mediated; however, there may be non-IgE and certain non-specific hypersensitivity mechanisms. Read More

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December 2018

Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells.

Cell Microbiol 2018 Dec 14:e12992. Epub 2018 Dec 14.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Read More

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December 2018

[Observation on pollinosis with vegetable food allergy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1779-1783

Department of Allergy, Beijing Shijitan Hospital, Affiliated to Capital Medical University, Beijing, 100038, China.

To investigate the incidence of plant food allergy in patients with pollinosis and the effect of food allergens on the clinical symptoms of pollinosis patients. A total of 40 patients with pollinosis and food allergy attended to the allergy Department of Duolun People's Hospital of Inner Mongolia were accepted skin prick test of inhaled allergens while the rhino conjunctivitis quality of life questionnaire(RQLQ) were also completed. The patients were divided into A and B groups randomly. Read More

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December 2018
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[Gene expression profile analysis involved in pathogenesis of allergic rhinitis by using bioinformatics method as a novel way of drug screening].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1464-1468

Department of Otorhinolaryngology, Beijing Shijitan Hospital, Affiliated to Capital Medical University.

To analyze the dynamic changes of the clinical features of chronic rhinosinusitis in recent 10 years, so as to deeply understand the characteristics of chronic rhinosinusitis, and to provide new ideas for treatment of chronic rhinosinusitis. This retrospective study was performed in patients who were diagnosed as chronic rhinosinusitis and enrolled. General information, clinical examination and pathological results were all collected, then patients' age, gender, the incidence of asthma and allergic rhinitis, peripheral eosinophil percentage, olfactory dysfunction and pathological results were statistically analyzed. Read More

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October 2018

[Prevalence of allergy in children with acute rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1377-1382

Department of Otolaryngology, the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou, 325000, China.

To explore the prevalence of allergy in patients with acute rhinosinusitis (ARS) and evaluate the severity of symptoms in ARS children with or without allergy.Two hundred and seven children (4-12 years of age) with ARS and 85 children of control group were included in our research from June, 2016 to January, 2018. We use questionaire to collect the basic information of pediatric patients. Read More

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September 2018
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[The sensitization feature of artemisia allergy and the diagnosis value of skin prick test].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1860-1864

Department of Allergy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

The purpose of this study was to explore the sensitization feature of artemisia allergy and to assess the diagnostic value of skin prick test(SPT) compared with specific IgE(sIgE) test. One hundred and fifty-one patients with typical rhino-conjunctivitis symptoms during pollen season were enrolled and general information was recorded in this study. All subjects received SPT and sIgE test of artemisia allergen. Read More

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December 2018
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[Hypersensitivity to metal : myth or reality ?]

Rev Med Suisse 2018 Dec;14(631):2243-2247

Service d'orthopédie et traumatologie, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

So-called metal allergy is a new interesting subject in orthopedics. Two different ways of thinking prevail in the literature. In the German orthopaedic literature, the diagnosis of metal allergy is often described and considered a real pathology, while we can find a more skeptical approach to this entity in Anglo-Saxons literature. Read More

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December 2018

The Burden of Caring for a Child or Adolescent With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): An Observational Longitudinal Study.

J Clin Psychiatry 2018 Dec 11;80(1). Epub 2018 Dec 11.

Pediatric Divisions of Child & Adolescent Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA.

Objective: To describe the longitudinal association between disease severity, time established in clinical treatment, and caregiver burden in a community-based patient population diagnosed with pediatric acute-onset neuropsychiatric syndrome (PANS).

Methods: The study included an observational longitudinal cohort design, with Caregiver Burden Inventories (CBIs) collected between April 2013 and November 2016 at the Stanford PANS multidisciplinary clinic. Inclusion criteria for this study were as follows: pediatric patients meeting strict PANS/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) diagnostic criteria (n = 187), having a caregiver fill out at least 1 complete CBI during a disease flare (n = 114); and having family who lives locally (n = 97). Read More

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December 2018

Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis.

Pediatr Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medicine, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Introduction: Prevalence of fungi has been rising in the cystic fibrosis (CF) population. Scedosporium species (spp) is the second most common mold seen in the CF respiratory tract. However, the characteristics associated with Scedosporium isolation and its clinical implications are poorly understood. Read More

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December 2018

High prevalence of binge drinking among people living with HIV in four African countries.

J Int AIDS Soc 2018 Dec;21(12):e25202

Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, Sénégal.

Introduction: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa.

Methods: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in Côte d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Read More

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December 2018
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Early immune biomarkers and intermediate-term outcomes after heart transplant: Results of Clinical Trials in Organ Transplantation-18.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Cleveland Clinic Cleveland OH, USA.

Clinical Trials in Organ Transplantation-18 (CTOT-18) is a follow-up analysis of the 200-subject multicenter heart transplant CTOT-05 cohort. CTOT-18 aimed to identify clinical, epidemiological and biological markers associated with adverse clinical events past 1 year after transplant. We examined various candidate biomarkers including serum antibodies, angiogenic proteins, blood gene expression profiles and T-cell alloreactivity. Read More

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December 2018
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Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Gillberg Neuropsychiatry Centre (GNC), University of Gothenburg, Gothenburg, Sweden.

Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. Read More

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December 2018

Insights into the Pulmonary Vascular complications of heart failure with Preserved Ejection Fraction.

J Physiol 2018 Dec 13. Epub 2018 Dec 13.

Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence. While PH-HFpEF is defined by a high mean pulmonary artery pressure, high left ventricular end-diastolic pressure and a normal ejection fraction, some HFpEF patients develop PH in the presence of pulmonary vascular remodeling with a high transpulmonary pressure gradient or pulmonary vascular resistance. Aging, increased left atrial pressure and stiffness, mitral regurgitation, as well as features of metabolic syndrome, which include obesity, diabetes, and hypertension, are recognized as risk factors for PH-HFpEF. Read More

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December 2018

The effect of anti-IL-17 treatment on the reaction to a nickel patch test in patients with allergic contact dermatitis.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

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December 2018

Double-blinded randomized controlled trial to evaluate a multimedia surgical care tour in improving patient satisfaction and knowledge after functional endoscopic sinus surgery.

Int Forum Allergy Rhinol 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, Mount Sinai Medical Center, New York, NY.

Background: Current delivery of patient education is done during the clinic visit, where physicians or clinic staff have limited time for each patient. One potential solution is to provide a multimedia surgical care tour delivered to patients throughout the perioperative period. The purpose of the study is to evaluate the effectiveness of this surgical care tour in enhancing patient knowledge and satisfaction after functional endoscopic sinus surgery (FESS). Read More

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December 2018

Mortality and losses to follow-up among adolescents living with HIV in the IeDEA global cohort collaboration.

J Int AIDS Soc 2018 Dec;21(12):e25215

TREAT Asia/amfAR, The Foundation for AIDS Research, Bangkok, Thailand.

Introduction: We assessed mortality and losses to follow-up (LTFU) during adolescence in routine care settings in the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium.

Methods: Cohorts in the Asia-Pacific, the Caribbean, Central, and South America, and sub-Saharan Africa (Central, East, Southern, West) contributed data, and included adolescents living with HIV (ALHIV) enrolled from January 2003 and aged 10 to 19 years (period of adolescence) while under care up to database closure (June 2016). Follow-up started at age 10 years or the first clinic visit, whichever was later. Read More

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December 2018

Editorial comments on this issue of the Journal.

Pediatr Allergy Immunol 2018 Dec;29(8):787-788

Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.

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December 2018

Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later.

Allergy 2018 Dec 13. Epub 2018 Dec 13.

Inserm, Univ. Grenoble Alpes, CNRS, IAB, Team of environmental epidemiology applied to reproduction and respiratory health, 38000, Grenoble, France.

Background: Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long-term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20 years earlier. Read More

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December 2018

Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV.

Methods: Embase, PubMed, and Web of Science were searched for relevant studies. Read More

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December 2018

Factors associated with red blood cell, platelet, and plasma transfusions among inpatient hospitalizations: a nationally representative study in the United States.

Transfusion 2018 Dec 12. Epub 2018 Dec 12.

Department of Pathology, Johns Hopkins University, Baltimore, MD, United States.

Background: Demographic and hospital-level factors associated with red blood cell (RBC), plasma, and platelet transfusions in hospitalized patients across the U.S. are not well characterized. Read More

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December 2018

Draf IIB with superior septectomy: finding the "middle ground".

Int Forum Allergy Rhinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS.

Background: Previous studies have demonstrated a high failure rate of endoscopic sinus surgery (ESS) with Draf IIa in patients with diffuse polyposis, asthma, and aspirin-exacerbated respiratory disease. A high percentage of these patients progress to endoscopic modified Lothrop procedure (EMLP). We describe a modification of the Draf IIb with a superior septectomy (IIb+SS), which may provide similar therapeutic benefit as demonstrated by the distribution of sinus irrigations in the sinus cavity with ESS with IIb+SS vs ESS with EMLP IIb+SS vs ESS with EMLP. Read More

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December 2018

African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children.

Pediatr Pulmonol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil.

Background: Genetic variants underlying African ancestry have been suggested be implicated in the ethnic-racial inequalities reported for asthma and allergies.

Objectives: To investigate the association between individual African ancestry and asthma symptoms, atopic and non-atopic asthma, and atopy in children.

Methods: A cross-sectional study encompassing 1190 individuals was conducted. Read More

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December 2018
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Alternaria-induced barrier dysfunction of nasal epithelial cells: role of serine protease and reactive oxygen species.

Int Forum Allergy Rhinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu, South Korea.

Background: Upper airway barrier dysfunction has been associated with chronic rhinosinusitis and allergic rhinitis. Alternaria is commonly found in nasal secretion and plays a role in the pathogenesis of airway diseases. The aim of this study was to investigate the effects of Alternaria on the junctional complex of nasal epithelial cells. Read More

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December 2018

Gastroesophageal reflux disease increases the risk of chronic rhinosinusitis: a nested case-control study using a national sample cohort.

Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.

Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, Korea.

Background: The purpose of this study was to evaluate the relations between gastroesophageal reflux disease (GERD) and chronic rhinosinusitus (CRS) in a Korean population.

Methods: Subjects from the Korean National Health Insurance Service-National Sample Cohort, all ≥20 years old, were assessed from 2002 to 2013. In total, 23,489 CRS participants were matched with 93,956 controls at a ratio of 1:4 with respect to age, group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. Read More

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December 2018

Socioeconomic factors impact quality of life outcomes and olfactory measures in chronic rhinosinusitis.

Int Forum Allergy Rhinol 2018 Dec 10. Epub 2018 Dec 10.

Division of Rhinology and Sinus/Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, OR.

Background: Healthcare disparities related to socioeconomic factors may adversely impact disease states and treatment outcomes. Among patients with chronic rhinosinusitis (CRS), the impact of socioeconomic factors on outcomes following endoscopic sinus surgery (ESS) remains uncertain.

Methods: Adult patients with refractory CRS were prospectively enrolled into an observational, multi-institutional cohort study between March 2011 and June 2015. Read More

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December 2018

Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study.

Environ Health 2018 Dec 14;17(1):89. Epub 2018 Dec 14.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa, 252-0392, Japan.

Introduction: Multiple chemical sensitivity (MCS) is characterized by recurrent nonspecific symptoms that are attributed to exposure to trace levels of environmental agents. Although the clinical symptoms of MCS have been described in several studies, the risk factors for this condition remain unclear. Our aim was to clarify the risk factors for MCS and the association between MCS and birth by caesarean section. Read More

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December 2018

Dramatic response to low-dose rivaroxaban in an Asian patient with deep vein thrombosis and pulmonary embolism.

J Cardiol Cases 2013 Aug 7;8(2):e77-e80. Epub 2013 Jun 7.

Division of Cardiovascular Medicine, Toshiba General Hospital, Tokyo, Japan.

We report a case of deep venous thrombosis and pulmonary embolism treated with rivaroxaban due to warfarin allergy. The patient responded well to a low dose of 15 mg/day. There has been a report about treating patients with atrial fibrillation using a low dose of rivaroxaban in Japan, but no previous reports about deep vein thrombosis/pulmonary embolism. Read More

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Kounis syndrome triggered by diclofenac sodium injection which leads to myocardial infarction and cardiac arrest.

J Cardiol Cases 2013 Jul 6;8(1):e17-e19. Epub 2013 Apr 6.

Department of Cardiology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Allergic reactions due to drugs may lead to different clinical conditions. Acute coronary syndromes triggered by Type 1 hypersensitivity reactions due to drug intake are known as "Kounis syndrome." Vasospasm occurring in normal coronary arteries (Type 1) and plaque rupture (Type 2) are two variants of this syndrome; both caused by vasoactive and inflammatory mediators due to hypersensitivity reaction. Read More

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Eosinophilia associated with dobutamine allergy causes eosinophilic endomyocarditis confirmed by serial endomyocardial biopsies.

J Cardiol Cases 2012 Dec 19;6(6):e179-e182. Epub 2012 Sep 19.

Department of Cardiovascular Medicine, Heart Failure Division, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita 565-8565, Japan.

We report a case of eosinophilic endomyocarditis caused by eosinophilia due to dobutamine allergy and successfully treated by a short-term and medium-dose steroid administration. Serial endomyocardial biopsies were useful for early diagnosis and evaluation of the effect of the treatment. Eosinophilic endomyocarditis due to dobutamine allergy is a rare entity; however, because of the high utilization rate of dobutamine in patients with low output heart failure, it is important to recognize that additional deterioration of cardiac function caused by eosinophilic endomyocarditis makes prognosis poor and early intervention is necessary. Read More

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December 2012

Pathological analysis of a case with peri-stent contrast staining after BMS implantation.

J Cardiol Cases 2016 Dec 9;14(6):161-163. Epub 2016 Sep 9.

Department of Laboratory Medicine, Kokura Memorial Hospital, Kokura, Japan.

A 68-year-old female underwent bare-metal stent (BMS) implantation in the right coronary artery (RCA) for ST-segment elevation myocardial infarction. Recurrent refractory restenosis with peri-stent contrast staining (PSS) formation was observed in the stented lesion at follow-up angiography at 7, 11, and 14 months after the index stent implantation. After 2 repeated interventions, this patient was referred to coronary artery bypass grafting due to occlusion of RCA and progression of proximal left anterior descending coronary artery lesion at 15 months after stent implantation. Read More

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December 2016

Kounis syndrome and hypersensitivity myocarditis - One and the same? Insights from cardiac magnetic resonance imaging.

J Cardiol Cases 2015 Oct 17;12(4):119-122. Epub 2015 Jul 17.

Royal Adelaide Hospital, Adelaide, Australia.

Myocarditis and acute coronary syndrome are both described in the setting of concurrent hypersensitivity reactions to a variety of allergenic triggers (hypersensitivity myocarditis and Kounis syndrome respectively). Mast cell degranulation is thought to be pivotal in the pathogenesis of both clinical entities. Cardiac magnetic resonance imaging (CMR) has assumed a key role in the assessment of chest pain syndromes, providing a useful non-invasive tool to aid clinical decision-making. Read More

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October 2015

Editorial: Kounis syndrome (allergic angina and allergic myocardial infarction) for cardiologists.

J Cardiol Cases 2015 Oct 14;12(4):110-112. Epub 2015 Aug 14.

Department of Cardiology, Ehime Prefectural Niihama Hospital, Ehime, Japan.

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October 2015

Coping with Asthma in Racially and Ethnically Diverse Urban Children: The Role of Emotional Problems in Disease Control.

Child Health Care 2017 16;46(2):151-169. Epub 2016 May 16.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.

This study examined cross-sectional associations among coping, mental health, and asthma outcomes in racially/ethnically diverse urban children. Children (N=42; 65% female) ages 9 to 17 (M=11.9) years old and their parents reported on the child's coping, emotional and conduct problems, asthma control, and school missed due to asthma. Read More

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A novel, accelerated method of desensitization in a patient with a documented hypersensitivity reaction to clopidogrel.

J Cardiol Cases 2010 Jun 27;1(3):e158-e160. Epub 2010 Jan 27.

Rush University Medical Center, Chicago, IL, USA.

Current standard of care following a percutaneous coronary intervention with stent placement necessitates the use of dual anti-platelet therapy with aspirin and commonly clopidogrel. There is a subset of patients who have a significant clopidogrel allergy and life-threatening hypersensitivity reactions. Desensitization is the process of inducing tolerance to a sensitizing agent via repeated exposure to the agent. Read More

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Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
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The bacteriology in adult patients with pneumonia and parapneumonic effusions: increased yield with DNA sequencing method.

Eur J Clin Microbiol Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, Solna, Infectious Diseases Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

The aim of this study was to use a 16S rDNA sequencing method in combination with conventional culture in patients with parapneumonic effusions (PPE) to evaluate the methods, study the microbiological spectrum, and examine the presence of bacteria within the different stages of PPE. Adults with community-acquired pneumonia (CAP) and PPE (n = 197) admitted to the Departments of Infectious Diseases at four hospitals in Stockholm County during 2011-2014 were prospectively studied. All patients underwent thoracentesis. Read More

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December 2018

The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study.

Open Forum Infect Dis 2018 Dec 17;5(12):ofy306. Epub 2018 Nov 17.

The National Centre for Infections in Cancer, Department of Infectious Diseases, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Antibiotic allergies are reported by up to 1 in 4 cancer patients, almost 50% of which are considered low risk and precede the cancer diagnosis. We demonstrate the successful and safe implementation of a pilot oral penicillin challenge program for cancer patients with low-risk penicillin allergies, increasing the use of penicillin and narrow-spectrum beta-lactams post-testing. Read More

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December 2018

Novel vaccines targeting dendritic cells by coupling allergoids to mannan.

Allergo J Int 2018 18;27(8):256-262. Epub 2018 May 18.

1Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain.

Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems related to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoallergenic molecules. Read More

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Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.

Allergo J Int 2018 9;27(8):245-255. Epub 2018 Jul 9.

9Jenner Institute, University of Oxford, Oxford, UK.

Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Read More

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Not All Rashes Are Allergic: Keratoderma Blennorrhagicum-Like Rash Masquerading as Contact Dermatitis.

Allergy Rhinol (Providence) 2018 Jan-Dec;9:2152656718811566. Epub 2018 Dec 4.

Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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December 2018

Transarterial chemoembolization in a patient with severe reactions to iodinated contrast: Successful treatment using gadolinium contrast with C-arm computed tomography.

Radiol Case Rep 2019 Mar 4;14(3):299-303. Epub 2018 Dec 4.

University of Louisville, Department of Radiology, Louisville, KY 40202, USA.

Severe reactions to modern iodinated contrasts are uncommon. Breakthrough reactions in the setting of pretreatment with corticosteroids are even rarer. Patients with a history of these refractory reactions can create challenging situations in the diagnostic and therapeutic process. Read More

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Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Exp Ther Med 2018 Dec 19;16(6):4445-4456. Epub 2018 Sep 19.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. Read More

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December 2018