463,703 results match your criteria Allergy & Rhinology [Journal]


Inspiratory and Expiratory Flow Changes, Voice Symptoms and Laryngeal Findings during Histamine Challenge Tests.

Folia Phoniatr Logop 2019 Apr 24:1-7. Epub 2019 Apr 24.

Department of Otorhinolaryngology and Phoniatrics, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objective: The aim of this study was to analyse the associations between the spirometry parameter changes in relation to laryngeal finding changes and self-reported voice and throat symptom changes among patients undergoing a histamine challenge test.

Patients And Methods: Thirty adult patients with a chronic cough underwent a histamine challenge test. Videolaryngostroboscopy and voice and throat symptoms were assessed using a visual analogue scale immediately before and after the challenge test. Read More

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http://dx.doi.org/10.1159/000495783DOI Listing

Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study.

Int Arch Allergy Immunol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Augsburg, Germany,

Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet.

Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Read More

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https://www.karger.com/Article/FullText/499042
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http://dx.doi.org/10.1159/000499042DOI Listing
April 2019
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Minimally Invasive Trigeminal Ablation: Long Buccal Nerve.

J Oral Facial Pain Headache 2019 Apr 24. Epub 2019 Apr 24.

Aims: To describe a technique of minimally invasive trigeminal nerve ablation of the long buccal nerve that was performed at a tertiary care academic medical center.

Methods: This case describes a 44-year-old woman with refractory left long buccal nerve neuropathy following a dental procedure. After failing medical management, she was taken for nerve exploration, which revealed no nerve discontinuity or neuroma formation. Read More

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http://dx.doi.org/10.11607/ofph.2341DOI Listing

Food allergy knowledge, attitudes and their determinants among restaurant staff: A cross-sectional study.

PLoS One 2019 24;14(4):e0214625. Epub 2019 Apr 24.

Family Medicine and Primary Care, Lee Kong Chian School of Medicine, Mandalay, Nanyang Technological University Singapore, Singapore, Singapore.

Background: There is wide international variation regarding food allergy knowledge among restaurant staff. Further, attitudes towards food allergy remain under-researched. Insights into the independent determinants of knowledge and attitudes are limited due to lacking mutual statistical adjustment for determinants/confounders in the vast majority of prior studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214625PLOS

HIV infection is an independent risk factor for decreased 6-minute walk test distance.

PLoS One 2019 24;14(4):e0212975. Epub 2019 Apr 24.

Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

Background: Ambulatory function predicts morbidity and mortality and may be influenced by cardiopulmonary dysfunction. Persons living with HIV (PLWH) suffer from a high prevalence of cardiac and pulmonary comorbidities that may contribute to higher risk of ambulatory dysfunction as measured by 6-minute walk test distance (6-MWD). We investigated the effect of HIV on 6-MWD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212975PLOS
April 2019
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Sustained Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Severe Chronic Plaque Psoriasis from a Randomised, Double-Blind, Phase 3 Study.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Venerology and Allergy, Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Adalimumab (Humira , AbbVie Inc, USA) is EMA approved for children ages ≥4 years with severe plaque-psoriasis.

Objectives: Evaluate long-term efficacy and safety of adalimumab in children with severe plaque psoriasis.

Methods: Results are from the 52-week long-term extension (LTE) of the randomized, double-blind, double-dummy, phase-3 trial, in children with severe plaque psoriasis (results from prior periods are published). Read More

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http://dx.doi.org/10.1111/bjd.18029DOI Listing

Xeroderma Pigmentosum in South Africa: Evidence for a prevalent founder effect.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

National Reference Center for Rare Skin Disorders, CHU de Bordeaux, Bordeaux, France.

Xeroderma pigmentosum (XP) is a rare, autosomal, recessive disease caused by defective repair of UV-induced DNA lesions due to various genetic defects affecting genes involved in the nucleotide excision repair (NER) pathway. Seven complementation groups have been described and named XP-A to XP-G, (OMIM 278700, 610651, 278720, 278730, 278740, 278760, 278780) with an additional XP variant form due to a defect in translesion DNA synthesis (OMIM 278750). Clinical manifestations are caused by the cutaneous and mucosal hypersensitivity to UV exposure, which induces multiple precocious cancerous lesions and premature skin aging. Read More

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http://dx.doi.org/10.1111/bjd.18030DOI Listing

Nevirapine in HIV maintenance therapy - can "old drugs" survive in current HIV management?

Swiss Med Wkly 2019 Apr 24;149:w20053. Epub 2019 Apr 24.

Cantonal Hospital St.Gallen, Department of Infectious Diseases and Hospital Epidemiology, St. Gallen, Switzerland / Children's Hospital of Eastern Switzerland, Department of Infectious Diseases and Hospital Epidemiology, St. Gallen, Switzerland.

Aims Of The Study: Nevirapine has an exceptional record for long-term tolerability with few side effects in human immunodeficiency virus (HIV) combined antiretroviral therapy (cART). Owing to relatively frequent hypersensitivity reactions (HSR) (15–25%) in the first 3 months after treatment initiation (especially in patients with a high CD4 count (>250/µl in women, >400/µl in men)), it is being used less and less. However, the rate of adverse events is lower when patients are already under suppressive cART. Read More

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http://dx.doi.org/10.4414/smw.2019.20053DOI Listing

enters a double membraned compartment following cell-cell transfer.

Elife 2019 Apr 24;8. Epub 2019 Apr 24.

School of Global Animal Health, Washington State University, Pullman, United States.

Previously, we found that phagocytic cells ingest bacteria directly from the cytosol of infected cells without killing the initially infected cell (Steele et al. 2016). Here, we explored the events immediately following bacterial transfer. Read More

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http://dx.doi.org/10.7554/eLife.45252DOI Listing

Post-reperfusion plasma endothelial activation markers are associated with acute kidney injury after lung transplantation.

Am J Transplant 2019 Apr 24. Epub 2019 Apr 24.

Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Acute kidney injury (AKI) is common after lung transplantation, but molecular markers remain poorly studied. The endothelial activation markers soluble thrombomodulin (sTM), protein C, and plasminogen activator inhibitor-1 (PAI-1) are implicated in kidney microcirculatory injury in animal models of AKI. We tested the association of 6-hour post-reperfusion plasma levels of these markers with post-transplant AKI severity in patients enrolled in the Lung Transplant Outcomes Group prospective cohort study at the University of Pennsylvania during two eras: 2004-06 (n=61) and 2013-15 (n=67). Read More

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http://dx.doi.org/10.1111/ajt.15402DOI Listing

Association Between Component-Resolved Diagnosis of House Dust Mite Allergy and Efficacy and Safety of Specific Immunotherapy.

J Investig Allergol Clin Immunol 2019 Apr;29(2):164-167

Servicio de Alergologia, Complejo Hospitalario de Navarra, Pamplona, Spain.

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http://dx.doi.org/10.18176/jiaci.0359DOI Listing

Basal Tryptase Levels Can Predict Clinical Severity in Hymenoptera Venom Anaphylaxis and Ischemic Cardiovascular Disorders.

J Investig Allergol Clin Immunol 2019 Apr;29(2):162-164

Department of Allergology and Immunology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.18176/jiaci.0363DOI Listing

Two Neonatal Cases of Food Protein-Induced Enterocolitis Syndrome With Pale Stool and Transient Biliary Dilatation.

J Investig Allergol Clin Immunol 2019 Apr;29(2):158-159

Department of Pediatrics, Saitama Medical Center Jichi Medical University, Saitama, Japan.

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http://dx.doi.org/10.18176/jiaci.0360DOI Listing

Actin as a Possible Cross-Reactive Allergen Between Fish and Poultry.

J Investig Allergol Clin Immunol 2019 Apr;29(2):152-154

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Alcalá de Henares, Spain.

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http://dx.doi.org/10.18176/jiaci.0357DOI Listing

Actin Allergen of Common Periwinkle Sea Snail (Littorina littorea).

J Investig Allergol Clin Immunol 2019 Apr;29(2):150-152

Department of Immunology, IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0356DOI Listing

Allergens Are Not Detected in the Bronchoalveolar Lavage Fluid of Patients Undergoing Fiberoptic Bronchoscopy.

J Investig Allergol Clin Immunol 2019 Apr;29(2):148-150

Neumology and Allergy Service, Hospital Clinic, Barcelona, Spain.

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http://dx.doi.org/10.18176/jiaci.0353DOI Listing

Isotretinoin in Severe Peanut- and Soy-Allergic Patients: Is it Safe or Not?

J Investig Allergol Clin Immunol 2019 Apr;29(2):146-148

KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium.

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http://dx.doi.org/10.18176/jiaci.0352DOI Listing

Salmon Roe as an Emerging Allergen in Western Countries.

J Investig Allergol Clin Immunol 2019 Apr;29(2):139-141

Serviço de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

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http://dx.doi.org/10.18176/jiaci.0347DOI Listing

Clinical Patterns of Heparin Allergy: Cross-reactivity Between Low-Molecular-Weight Heparins and Unfractionated Heparins.

J Investig Allergol Clin Immunol 2019 Apr;29(2):132-134

Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

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http://dx.doi.org/10.18176/jiaci.0342DOI Listing

Is Quantitative sIgE Serology Suitable for Distinguishing Between Silent Sensitization and Allergic Rhinitis to Dermatophagoides pteronyssinus?

J Investig Allergol Clin Immunol 2019 Apr;29(2):124-131

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Hospital, Munich, Germany.

Background And Objective: An increasing number of studies have recently discussed whether provocation tests might be replaced by specific IgE serology in patients sensitized to airborne allergens. Objective: Our study aimed to analyze the concordance between a nasal provocation test with Dermatophagoides pteronyssinus and specific IgE measurements based on real-life data.

Methods: We retrospectively analyzed concordance between the result of the provocation test and the IgE titer for house dust mite components and extracts in 223 patients with proven sensitization to D pteronyssinus. Read More

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http://dx.doi.org/10.18176/jiaci.0299DOI Listing

Favorable Prognosis of Wheat Allergy in Adults.

J Investig Allergol Clin Immunol 2019 Apr;29(2):118-123

Unit of Allergology and Immunology, Dipartimento Medico Polispecialistico, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.

Background And Objective: Wheat ingestion can lead to disorders such as IgE-mediated food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA), both of which are associated with impaired quality of life and significant morbidity. Allergy to wheat is relatively benign in children, although its natural history in adults is still unknown. Objective: We used placebo-controlled challenge to evaluate the natural history of wheat hypersensitivity in atopic patients with adultonset wheat allergy. Read More

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http://dx.doi.org/10.18176/jiaci.0296DOI Listing

Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma.

J Investig Allergol Clin Immunol 2019 Apr;29(2):84-93

Department of Allergy, Hospital Universitario La Paz Institute for Health Research (IdiPAZ) and CIBER of Respiratory Diseases (CIBERES), Madrid, Spain.

Eosinophilic asthma is the most common phenotype of severe asthma. It is characterized by abnormal production and release of type 2 cytokines from T helper type 2 (TH2) lymphocytes and type 2 innate lymphoid cells, such as IL-5. This leads to a persistent increase and activation of eosinophils in blood and the airways despite treatment with high-dose inhaled corticosteroids. Read More

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http://dx.doi.org/10.18176/jiaci.0385DOI Listing

Loquat (Eriobotrya japonica) allergy, including anaphylaxis, is induced by a Bet v1 homolog.

J Investig Allergol Clin Immunol 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Education, Shitennoji University, Habikino, Japan.

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http://dx.doi.org/10.18176/jiaci.0406DOI Listing

Usefulness of basophil activation test in the diagnosis of amiodarone hypersensitivity.

J Investig Allergol Clin Immunol 2019 Apr 24. Epub 2019 Apr 24.

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid. Spain.

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http://dx.doi.org/10.18176/jiaci.0404DOI Listing

Beyond Blood Smears-Qualification of the 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

Am J Trop Med Hyg 2019 Apr 22. Epub 2019 Apr 22.

Department of Microbiology, University of Washington, Seattle, Washington.

18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic sites that used blood smears and 18S rRNA/rDNA biomarker nucleic acid tests (NATs) for time to positivity. We validated a multiplex quantitative reverse transcription-PCR (qRT-PCR) for 18S rRNA, prospectively compared blood smears and qRT-PCR for three trials, and modeled treatment effects at different biomarker-defined parasite densities to assess the impact on infection detection, symptom reduction, and measured intervention efficacy. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0094DOI Listing

Usability of mepolizumab single-use prefilled syringe for patient self-administration.

J Asthma 2019 Apr 24:1-10. Epub 2019 Apr 24.

g Respiratory Therapeutic Area, GSK , Research Triangle Park , NC , USA.

Objective: A liquid mepolizumab formulation in a single-use prefilled syringe (PFS) is under development. We evaluated the usability of mepolizumab self-injected via PFS by patients with severe eosinophilic asthma (SEA), or their caregivers, in clinic and at home.

Methods: This open-label, single-arm, Phase IIIa study included patients with SEA, aged ≥12 years, and receiving mepolizumab (100 mg subcutaneously) every 4 weeks for ≥12 weeks prior to screening. Read More

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https://www.tandfonline.com/doi/full/10.1080/02770903.2019.1
Publisher Site
http://dx.doi.org/10.1080/02770903.2019.1604745DOI Listing
April 2019
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Clinical Efficacy of Allergen-Specific Immunotherapy from Patient and Physician Perspectives.

Yonsei Med J 2019 May;60(5):446-453

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Purpose: Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, but a few allergic patients receive AIT. In this multicenter cross-sectional study, we aimed to explore patient and physician perspectives on AIT through a questionnaire survey.

Materials And Methods: Allergic patients who received subcutaneous immunotherapy for at least 1 year were asked to answer a questionnaire developed by an expert panel of allergen and immunotherapy workgroup in Korea. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.5.446DOI Listing

Proteomics in Primary Biliary Cholangitis.

Methods Mol Biol 2019 ;1981:163-173

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Primary biliary cholangitis is a chronic cholestatic liver disease characterized by the presence of serum antimitochondrial antibodies and immune-mediated destruction of the small and medium-sized intrahepatic bile ducts. However, the pathophysiology of primary biliary cholangitis has not yet been completely elucidated. In recent years, proteomics has been comprehensively applied in many research fields, including the pathogenesis, prognosis, and diagnosis of disease. Read More

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http://dx.doi.org/10.1007/978-1-4939-9420-5_11DOI Listing
January 2019

Successful Lung Transplantation in a Patient with Chronic Granulomatous Disease.

J Clin Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/s10875-019-00623-6DOI Listing

Growth Trajectories of Peer Norms, Self-efficacy and Condom Use Behavior Among Sexually Active Chinese Men Who Have Sex with Men: Latent Class Analysis and Growth Mixture Modeling.

AIDS Behav 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, School of Public Health, Shandong University, 44 West Wenhua Road, Jinan, 250012, Shandong, China.

Data from a randomized controlled trial in 2015 were used to estimate the growth trajectories of peer norms, self-efficacy, and condom use behavior, and to identify associated sociodemographic and behavioral factors among a sample of 804 Chinese men who have sex with men (MSM). Latent class analysis and growth mixture modeling were conducted using Mplus. Two growth trajectories were estimated for each outcome variable with good model fit. Read More

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http://dx.doi.org/10.1007/s10461-019-02515-7DOI Listing

[Perspectives for nationwide pollen monitoring in Germany].

Authors:

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr 23. Epub 2019 Apr 23.

Allergenic pollen are natural, biological airborne particles and the main cause of allergic respiratory diseases. The measurement of allergenic pollen is a required measure in preventive healthcare and indicates changes in the pollen spectrum as to be expected in the context of climate change.The only nationwide pollen measuring network in Germany is operated by the Foundation German Pollen Information Service, however, its continuity and further development (a hybrid system with manual and automated pollen traps) are not financially guaranteed. Read More

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http://dx.doi.org/10.1007/s00103-019-02940-yDOI Listing

Rabies-based vaccine induces potent immune responses against Nipah virus.

NPJ Vaccines 2019 15;4:15. Epub 2019 Apr 15.

1Department of Microbiology and Immunology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107 USA.

Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus of the family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (human case fatality rate = 74.5%). Read More

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http://www.nature.com/articles/s41541-019-0109-5
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http://dx.doi.org/10.1038/s41541-019-0109-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465360PMC
April 2019
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The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option.

Allergy Asthma Clin Immunol 2019 16;15:24. Epub 2019 Apr 16.

5Department of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes. Read More

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http://dx.doi.org/10.1186/s13223-018-0314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469109PMC

Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea.

Allergy Asthma Clin Immunol 2019 16;15:23. Epub 2019 Apr 16.

2Department of Anesthesia, McGill University Health Center, 1001 Decarie Boulevard, Montreal, QC H4A 3J1 Canada.

Background: Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and systemic inflammation. However, the sequence of events leading to the morbidities associated with OSA is poorly understood in children. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0338-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469051PMC
April 2019
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Summary of the NACI Update on Herpes Zoster Vaccines.

Can Commun Dis Rep 2018 Sep 6;44(9):220-225. Epub 2018 Sep 6.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Steep increases in herpes zoster (HZ) incidence, hospitalization due to HZ and the risk of post-herpetic neuralgia as a complication of HZ occur in people over 50 years of age. Two HZ vaccines are currently authorized for use in those 50 years of age and older in Canada: a live attenuated zoster vaccine (LZV) authorized in 2008; and a recombinant subunit vaccine (RZV) authorized in October 2017.

Objectives: To review current evidence and develop guidance on whether the previously authorized LZV (Zostavax) and/or the recently authorized RZV (Shingrix) vaccine should be offered to Canadians 50 years of age and older: 1) at a population-level, in publicly funded immunization programs; and 2) at an individual-level, to individuals wishing to prevent HZ, or by clinicians wishing to advise individual patients about preventing HZ. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449089PMC
September 2018

Association of Genetic Variants of , , and with Ankylosing Spondylitis Clinical Features in Taiwanese.

Mediators Inflamm 2019 20;2019:8029863. Epub 2019 Mar 20.

Attending Physician, Department of Medicine, Division of Allergy, Immunology and Rheumatology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taiwan.

Ankylosing spondylitis (AS) is a chronic inflammatory disease that leads to spinal ankylosis. The receptor activator of the nuclear factor-kappa (RANK), RANK ligand, and osteoprotegerin (OPG) (RANK/RANKL/OPG) pathway plays critical roles in bone metabolism and the immune system. The current study was aimed at investigating whether six single-nucleotide polymorphisms (SNPs) within the , , and genes essential for bone homeostasis are associated with AS. Read More

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http://dx.doi.org/10.1155/2019/8029863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446096PMC

A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry.

Sci Rep 2019 Apr 23;9(1):6467. Epub 2019 Apr 23.

Myles H. Thaler Center for HIV and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia, USA.

The ability to overcome cellular restrictions that exist for the export and translation of mRNAs with retained introns is a requirement for the replication of retroviruses and also for the expression of many mRNA isoforms transcribed from cellular genes. In some cases, RNA structures have been identified in the mRNA that directly interact with cellular factors to promote the export and expression of isoforms with retained introns. In other cases, a viral protein is also required to act as an adapter. Read More

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http://dx.doi.org/10.1038/s41598-019-42914-3DOI Listing

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 Apr 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). Read More

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing

Transcriptional regulation of voltage-gated sodium channels contributes to GM-CSF induced pain.

J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

Department of Pharmacology, Hebei Medical University; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Hebei Province; Shijiazhuang, China.

Granulocyte-macrophage colony stimulating factor (GM-CSF) induces production of granulocyte and macrophage populations from the hematopoietic progenitor cells; it is one of the most common growth factors in the blood. GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. However, the precise mechanism for GM-CSF-dependent pain is unclear. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2204-18.2019DOI Listing

Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus.

MBio 2019 Apr 23;10(2). Epub 2019 Apr 23.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA

Tick-borne encephalitis virus (TBEV), a member of the genus , is one of the most medically important tick-borne pathogens of the Old World. Despite decades of active research, attempts to develop of a live attenuated virus (LAV) vaccine against TBEV with acceptable safety and immunogenicity characteristics have not been successful. To overcome this impasse, we generated a chimeric TBEV that was highly immunogenic in nonhuman primates (NHPs). Read More

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http://dx.doi.org/10.1128/mBio.02904-18DOI Listing

Chlamydia trachomatis Lipopolysaccharide Evades the Canonical and Noncanonical Inflammatory Pathways To Subvert Innate Immunity.

MBio 2019 Apr 23;10(2). Epub 2019 Apr 23.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

is the most common bacterial cause of sexually transmitted infections. sexually transmitted infections are commonly asymptomatic, implying a pathogenic strategy for the evasion of innate inflammatory immune responses, a paradox as the outer membrane contains lipopolysaccharide (LPS), a known potent agonist of inflammatory innate immunity. Here, we studied the ability of chlamydial LPS to activate the proinflammatory canonical and noncanonical inflammasome pathways in mouse bone marrow-derived macrophages (BMDM). Read More

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http://dx.doi.org/10.1128/mBio.00595-19DOI Listing

The Impact of Anthelmintic Treatment on Human Gut Microbiota Based on Cross-Sectional and Pre- and Postdeworming Comparisons in Western Kenya.

MBio 2019 Apr 23;10(2). Epub 2019 Apr 23.

Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Murine studies suggest that the presence of some species of intestinal helminths is associated with changes in host microbiota composition and diversity. However, studies in humans have produced varied conclusions, and the impact appears to vary widely depending on the helminth species present. To demonstrate how molecular approaches to the human gut microbiome can provide insights into the complex interplay among disparate organisms, DNA was extracted from cryopreserved stools collected from residents of 5 rural Kenyan villages prior to and 3 weeks and 3 months following albendazole (ALB) therapy. Read More

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http://dx.doi.org/10.1128/mBio.00519-19DOI Listing
April 2019
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Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single centre.

Blood 2019 Apr 23. Epub 2019 Apr 23.

Great Ormond Street Hospital, Greece.

DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity and allergy. The aim of this study was to assess the impact of different factors in the development of infections, autoimmunity and/or allergy in patients with pDGS. Read More

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http://dx.doi.org/10.1182/blood.2018885244DOI Listing

The many abilities of omalizumab and the unbeaten path.

J Allergy Clin Immunol 2019 Apr 20. Epub 2019 Apr 20.

Allergy and Clinical Immunology, Medicine and Surgery Department, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1016/j.jaci.2019.02.035DOI Listing

Reply.

J Allergy Clin Immunol 2019 Apr 20. Epub 2019 Apr 20.

Department of Internal Medicine, Division of Allergy and Immunology, Morsani College of Medicine of the University of South Florida, Tampa, Fla. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.03.014DOI Listing

Particle toxicology and health - where are we?

Part Fibre Toxicol 2019 Apr 23;16(1):19. Epub 2019 Apr 23.

National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Background: Particles and fibres affect human health as a function of their properties such as chemical composition, size and shape but also depending on complex interactions in an organism that occur at various levels between particle uptake and target organ responses. While particulate pollution is one of the leading contributors to the global burden of disease, particles are also increasingly used for medical purposes. Over the past decades we have gained considerable experience in how particle properties and particle-bio interactions are linked to human health. Read More

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http://dx.doi.org/10.1186/s12989-019-0302-8DOI Listing

A network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy.

BMC Bioinformatics 2019 Apr 23;20(1):206. Epub 2019 Apr 23.

TNO, PO Box 360, 3700, AJ, Zeist, The Netherlands.

Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, concerns with regards to safety and long-term efficacy of OIT remain. There is a need to identify biomarkers that predict, monitor and/or evaluate the effects of OIT. Read More

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http://dx.doi.org/10.1186/s12859-019-2802-9DOI Listing

Asthma prevalence among women aged 18 to 44 in the United States: National health and nutrition examination survey 2001-2016.

J Asthma 2019 Apr 24:1-10. Epub 2019 Apr 24.

d HealthPartners Institute , Minneapolis , MN , USA.

Objective: To provide updated prevalence estimates of asthma and asthma medication use for women of childbearing age in the United States.

Methods: Using data from 11,383 women aged 18-44, including a subset of 1,245 pregnant women, enrolled in the National Health and Nutrition Examination Survey (2001-2016), we assessed the age-adjusted prevalence of self-reported diagnosed asthma. For women aged 18-44, we stratified by year, demographics, and other characteristics. Read More

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http://dx.doi.org/10.1080/02770903.2019.1602874DOI Listing