459,979 results match your criteria Allergy & Rhinology [Journal]


Chronic Rhinosinusitis: Does Allergy Play a Role?

Med Sci (Basel) 2019 Feb 18;7(2). Epub 2019 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, GA 30308, USA.

A few chronic rhinosinusitis (CRS) variants have demonstrated a strong association with environmental allergy, including allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD). However, the overall relationship between CRS and allergy remains poorly defined. The goal of this review is to evaluate the relationship between CRS and allergy with a focus on specific CRS variants. Read More

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http://dx.doi.org/10.3390/medsci7020030DOI Listing
February 2019

CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines.

Cells 2019 Feb 17;8(2). Epub 2019 Feb 17.

School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China.

N6-methyladenosine (m⁶A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m⁶A patterns across cell lines. Here we collected all available MeRIP-Seq and m⁶A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m⁶A peaks dependent on 23 human and eight mouse cell lines respectively. Read More

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http://www.mdpi.com/2073-4409/8/2/168
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http://dx.doi.org/10.3390/cells8020168DOI Listing
February 2019
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Ebola Virus Isolation Using Huh-7 Cells has Methodological Advantages and Similar Sensitivity to Isolation Using Other Cell Types and Suckling BALB/c Laboratory Mice.

Viruses 2019 Feb 16;11(2). Epub 2019 Feb 16.

Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 8200 Research Plaza, Frederick, MD 27102, USA.

Following the largest Ebola virus disease outbreak from 2013 to 2016, viral RNA has been detected in survivors from semen and breast milk long after disease recovery. However, as there have been few cases of sexual transmission, it is unclear whether every RNA positive fluid sample contains infectious virus. Virus isolation, typically using cell culture or animal models, can serve as a tool to determine the infectivity of patient samples. Read More

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http://dx.doi.org/10.3390/v11020161DOI Listing
February 2019

The effect of passive smoking on exhaled nitric oxide in asthmatic children.

Nitric Oxide 2019 Feb 16. Epub 2019 Feb 16.

Social Medicine Institute, Department of Social and Preventive Medicine, Medical University of Lodz, Poland.

To date, some studies suggest that passive smoking (PS) may be an important determinant of FeNO levels in children but sill there is a need of investigations using objective methods of PS exposure. The aim of our study was to examine the effect of PS, measured by urine cotinine levels, on FeNO and lung function (FEV1) in allergic and non-allergic asthmatic children. METHODS: It was a prospective, non-interventional study. Read More

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http://dx.doi.org/10.1016/j.niox.2019.01.012DOI Listing
February 2019

Angioedema following initiation of Glecaprevir/ Pibrentasvir while on Sitagliptin.

J Allergy Clin Immunol Pract 2019 Feb 16. Epub 2019 Feb 16.

Montefiore Medical Center, Bronx, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.02.008DOI Listing
February 2019

Safety of metformin in psoriasis patients with diabetes mellitus: a 17-year population-based real-world cohort study.

J Clin Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Context: The safety of metformin usage by diabetic psoriasis patients is unclear.

Objective: To investigate the real-world safety of metformin in psoriatic patients with type 2 diabetes mellitus (T2DM).

Design: We used the National Health Insurance Research Database to perform a cohort study. Read More

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http://dx.doi.org/10.1210/jc.2018-02526DOI Listing
February 2019

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

PLoS One 2019 19;14(2):e0210273. Epub 2019 Feb 19.

Division of Neurotoxicology, NCTR/U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America.

This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia. Whole blood messenger RNA (mRNA) and whole blood and serum microRNA (miRNA) transcripts were identified in adult male Sprague-Dawley rats after exposure to toxic AMPH under normothermic conditions, AMPH when it produces pronounced hyperthermia, or environmentally-induced hyperthermia (EIH). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210273PLOS
February 2019

The Cost-Effectiveness of Interventions to Increase Utilization of Prone Positioning for Severe Acute Respiratory Distress Syndrome.

Crit Care Med 2019 Mar;47(3):e198-e205

Palliative and Advanced Illness Research (PAIR) Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objectives: Despite strong evidence supporting proning in acute respiratory distress syndrome, few eligible patients receive it. This study determines the cost-effectiveness of interventions to increase utilization of proning for severe acute respiratory distress syndrome.

Design: We created decision trees to model severe acute respiratory distress syndrome from ICU admission through death (societal perspective) and hospital discharge (hospital perspective). Read More

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http://dx.doi.org/10.1097/CCM.0000000000003617DOI Listing

Adoption of a Closed-Loop Communication Tool to Establish and Execute a Collaborative Follow-Up Plan for Incidental Pulmonary Nodules.

AJR Am J Roentgenol 2019 Feb 19:1-5. Epub 2019 Feb 19.

1 Department of Radiology, Center for Evidence-Based Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.

Objective: The purpose of this study is to assess radiologists' adoption of a closed-loop communication and tracking system, Result Alert and Development of Automated Resolution (RADAR), for incidental pulmonary nodules and to measure its effect on the completeness of radiologists' follow-up recommendations.

Materials And Methods: This retrospective study was performed at a tertiary academic center that performs more than 600,000 radiology examinations annually. Before RADAR, the institution's standard of care was for radiologists to generate alerts for newly discovered incidental pulmonary nodules using a previously described PACS-embedded software tool. Read More

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http://dx.doi.org/10.2214/AJR.18.20692DOI Listing
February 2019

The Special Pathogens Research Network: Enabling Research Readiness.

Health Secur 2019 Jan/Feb;17(1):35-45

Christopher J. Kratochvil, MD, is Associate Vice Chancellor for Clinical Research, the University of Nebraska Medical Center, Omaha, NE.

The 2013-2016 epidemic of Ebola virus disease (EVD) that originated in West Africa underscored many of the challenges to conducting clinical research during an ongoing infectious disease epidemic, both in the most affected countries of Guinea, Liberia, and Sierra Leone, as well as in the United States and Europe, where a total of 27 patients with EVD received care in biocontainment units. The Special Pathogens Research Network (SPRN) was established in the United States in November 2016 to provide an organizational structure to leverage the expertise of the 10 Regional Ebola and Other Special Pathogen Treatment Centers (RESPTCs); it was intended to develop and support infrastructure to improve readiness to conduct clinical research in the United States. The network enables the rapid activation and coordination of clinical research in the event of an epidemic and facilitates opportunities for multicenter research when the RESPTCs are actively caring for patients requiring a biocontainment unit. Read More

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http://dx.doi.org/10.1089/hs.2018.0106DOI Listing
February 2019

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults.

N Engl J Med 2019 02 18. Epub 2019 Feb 18.

From the Division of Allergy, Pulmonary, and Critical Care Medicine (J.D.C., R.M.B., B.E.H., M.G.L., A.H.T., T.W.R., M.W.S.), and the Department of Emergency Medicine (W.H.S.), Vanderbilt University Medical Center, Nashville; the Section of Pulmonary, Critical Care, and Allergy and Immunology (D.R.J.), and the Section of Emergency Medicine (D.J.V.), Louisiana State University School of Medicine-New Orleans, and the Department of Pulmonary and Critical Care Medicine, Ochsner Health System (D.J.V., K.M.D.) - both in New Orleans; the Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham (D.W.R., A.N.Z., S.G.); and the Department of Anesthesiology and Pain Medicine (A.M.J.) and the Division of Pulmonary and Critical Care (I.B.), University of Washington School of Medicine, Seattle.

Background: Hypoxemia is the most common complication during tracheal intubation of critically ill adults and may increase the risk of cardiac arrest and death. Whether positive-pressure ventilation with a bag-mask device (bag-mask ventilation) during tracheal intubation of critically ill adults prevents hypoxemia without increasing the risk of aspiration remains controversial.

Methods: In a multicenter, randomized trial conducted in seven intensive care units in the United States, we randomly assigned adults undergoing tracheal intubation to receive either ventilation with a bag-mask device or no ventilation between induction and laryngoscopy. Read More

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http://dx.doi.org/10.1056/NEJMoa1812405DOI Listing
February 2019

Haemophagocytic lymphohistiocytosis secondary to presumed congenital tuberculosis in a neonate.

J Paediatr Child Health 2019 Feb 18. Epub 2019 Feb 18.

Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/jpc.14393DOI Listing
February 2019

Asthma with multiple allergic comorbidities is associated with complete response to omalizumab.

Clin Exp Allergy 2019 Feb 18. Epub 2019 Feb 18.

AP-HP, Groupe hospitalier Trousseau, La Roche Guyon, Centre de l'Asthme et des Allergies, Paris, France.

Patients with severe asthma constitute a heterogeneous population, and different phenotypes have been identified both in adults and children. Severe asthma affects 4.5% of children with current asthma. Read More

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http://dx.doi.org/10.1111/cea.13373DOI Listing
February 2019

Association between parental autoimmune disease and atopic dermatitis in their offspring: a matched case-control study.

J Eur Acad Dermatol Venereol 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Background: Atopic dermatitis (AD) is associated with many autoimmune diseases, in part due to overlapping genetic risk loci. While parental atopic disease is an important risk for AD in the offspring, little is known on the putative associations between parental autoimmune disease and AD in their children.

Materials And Methods: All children born between 1996 and 2011 who received a diagnosis of AD in the hospital system before their fifth birthday were matched 1 : 10 with children from the general population. Read More

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http://dx.doi.org/10.1111/jdv.15413DOI Listing
February 2019

Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study.

Transfusion 2019 Feb 18. Epub 2019 Feb 18.

Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Blood donation results in a loss of iron stores, which is particularly concerning for young female blood donors. This study examines the association of blood donation and iron deficiency among adolescent and adult females in the United States.

Study Design And Methods: A cross-sectional analysis was performed using data from the 1999-2010 National Health and Nutrition Examination Survey (NHANES). Read More

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http://dx.doi.org/10.1111/trf.15179DOI Listing
February 2019

A new source for isothiazolinone contact allergy in traditional, non-digital photography.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, University of Montpellier, France.

A 61-year-old patient was referred for a one-year history of relapsing itchy erythematous and vesicular lesions on the dorsa of the hands progressively extending to the neck, the neckline and the face (fig 1). Read More

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http://dx.doi.org/10.1111/cod.13245DOI Listing
February 2019

Contact Allergy and Allergic Contact Dermatitis to Lavender: A Retrospective Study from an Australian Clinic.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Skin and Cancer Foundation Inc, Occupational Dermatology Research and Education Centre, Carlton, Victoria, Australia.

Background: Lavender is commonly used in aromatherapy and in a broad range of personal and household products. It has been identified as a contact sensitizer and has been reported to cause allergic contact dermatitis (ACD).

Objectives: To report our experience with contact allergy and ACD to lavender and to raise awareness of lavender as a potential contact allergen. Read More

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http://dx.doi.org/10.1111/cod.13247DOI Listing
February 2019

T lymphocyte phenotype of contact allergic patients: experience with nickel and p-phenylenediamine.

Contact Dermatitis 2019 Feb 18. Epub 2019 Feb 18.

Faculty of Biology, Medicine and Health, University of Manchester.

Background: There is considerable interest in understanding the immunological variables that have the greatest influence on the effectiveness of sensitization by contact allergens, particularly in the context of developing new paradigms for risk assessment of novel compounds OBJECTIVES: To examine the relationship between patch test score for 3 different contact allergens and the characteristics of T-cell responses.

Patients/materials/methods: A total of 192 patients with confirmed nickel, p-phenylenediamine (PPD) or methylisothiazolinone allergy were recruited from the Contact Dermatitis Investigation Unit at Salford Royal Hospital. Severity of allergy was scored by patch testing and peripheral blood lymphocytes characterized for T cell phenotype by flow cytometry and proliferative activity by radiolabelled thymidine incorporation. Read More

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http://dx.doi.org/10.1111/cod.13246DOI Listing
February 2019

Joint reconstruction and classification of tumor cells and cell interactions in melanoma tissue sections with synthesized training data.

Int J Comput Assist Radiol Surg 2019 Feb 16. Epub 2019 Feb 16.

Institute for Numerical Simulation, University of Bonn, Bonn, Germany.

Purpose: Cancers are almost always diagnosed by morphologic features in tissue sections. In this context, machine learning tools provide new opportunities to describe tumor immune cell interactions within the tumor microenvironment and thus provide phenotypic information that might be predictive for the response to immunotherapy.

Methods: We develop a machine learning approach using variational networks for joint image denoising and classification of tissue sections for melanoma, which is an established model tumor for immuno-oncology research. Read More

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http://dx.doi.org/10.1007/s11548-019-01919-zDOI Listing
February 2019

Targeting Immune Checkpoints in Lung Cancer: Current Landscape and Future Prospects.

Clin Drug Investig 2019 Feb 16. Epub 2019 Feb 16.

Department of Pathology, School of Basic Medical Science, Wuhan University, 185 Donghu Road, Medical Building 8, 10th Floor, Wuchang District, Wuhan, 430071, Hubei, People's Republic of China.

Lung cancer is the most prevalent and deadly cancer worldwide. Immune checkpoint therapy, which targets regulatory pathways in T cells to boost anti-tumor immune response, has revolutionized lung cancer treatment paradigms. Inhibitors of the most established immune checkpoints such as programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) have been approved by the US Food and Drug Administration in the management of lung cancer. Read More

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http://dx.doi.org/10.1007/s40261-018-00746-5DOI Listing
February 2019

Desensitization of two young patients with infantile-onset Pompe disease and severe reactions to alglucosidase alfa.

Neurol Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Via S. Pansini 5, Naples, Italy.

Pompe disease is a metabolic myopathy, due to deficiency of alpha glucosidase, with a wide clinical spectrum. Enzyme replacement therapy is the only available treatment to improve morbidity and mortality, especially in infantile-onset form. However, some patients experience infusion-associated reactions, which may restrict their access to this treatment. Read More

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http://dx.doi.org/10.1007/s10072-019-03744-3DOI Listing
February 2019

Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV.

AIDS Behav 2019 Feb 18. Epub 2019 Feb 18.

Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Cannabis use is prevalent among HIV-positive persons, but evidence regarding the impact of cannabis in HIV-positive persons is limited. We conducted a retrospective cohort study of HIV-positive adults initiating their first antiretroviral therapy (ART) regimen. A dedicated intake form assessed self-reported cannabis use in the preceding 7 days at each visit. Read More

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http://dx.doi.org/10.1007/s10461-019-02430-xDOI Listing
February 2019

The effect of increased body mass index values on surgical outcomes after radical resection for low rectal cancer.

Surg Today 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Guo Xue Xiang No. 37, Chengdu, 610041, China.

Purposes: This study aimed to explore the effect of increased body mass index (BMI) values (overweight: BMI ≥ 25-30 kg/m; obese: BMI ≥ 30 kg/m) on surgical outcomes after radical resection for low rectal cancer (LRC).

Methods: Patients with LRC who underwent radical surgery from January 2009 to December 2013 were included. The patients were divided into three groups according to their BMI values (control group: BMI < 25 kg/m; overweight group: BMI 25 to < 30 kg/m; obese group: BMI ≥ 30 kg/m). Read More

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http://dx.doi.org/10.1007/s00595-019-01778-wDOI Listing
February 2019

Comparison of Er,Cr:YSGG and diode laser effects on dentin hypersensitivity: a split-mouth randomized clinical trial.

Clin Oral Investig 2019 Feb 18. Epub 2019 Feb 18.

Tehran University of Medical Sciences Research Center, Tehran, Iran.

Objectives: The aim of the present study was to compare the clinical efficacy of diode laser and Er,Cr:YSGG lasers in the treatment of dentin hypersensitivity.

Materials And Methods: Thirty-four teeth from 17 patients with dentin hypersensitivity were divided into two groups. In group D, the teeth were irradiated with diode laser beams with a wavelength of 940 nm for 1 min, and in group E, the teeth were irradiated with Er,Cr:YSGG laser beams with a wavelength of 2780 nm and a pulse width of 140-200 μs. Read More

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http://dx.doi.org/10.1007/s00784-019-02841-zDOI Listing
February 2019

Clinical Efficacy, Safety and Tolerability of a New Subcutaneous Immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the Treatment of Patients With Primary Immunodeficiencies.

Front Immunol 2019 4;10:40. Epub 2019 Feb 4.

Department of Clinical Immunology and Allergology, St Anne's University Hospital in Brno, Faculty of Medicine, Masaryk University, Brno, Czechia.

Subcutaneously administered immunoglobulin (SCIG) is increasingly used to treat patients with primary immunodeficiencies (PIDs). Octanorm (marketed as cutaquig® in USA and Canada) is a new 16.5% solution of human SCIG, manufactured by a process based on that of the intravenous preparation (IVIG) octagam®. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369354PMC
February 2019

Subsets of exhausted CD8 T cells differentially mediate tumor control and respond to checkpoint blockade.

Nat Immunol 2019 Mar 18;20(3):326-336. Epub 2019 Feb 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) reinvigorates T cells are not fully understood. Here we show that such therapy acts on a specific subpopulation of exhausted CD8 tumor-infiltrating lymphocytes (TILs). Dysfunctional CD8 TILs possess canonical epigenetic and transcriptional features of exhaustion that mirror those seen in chronic viral infection. Read More

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http://dx.doi.org/10.1038/s41590-019-0312-6DOI Listing

Alarming eosinophils to combat tumors.

Nat Immunol 2019 Mar;20(3):250-252

Mary H Weiser Food Allergy Center, Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41590-019-0318-0DOI Listing

Human CD8 T cell cross-reactivity across influenza A, B and C viruses.

Nat Immunol 2019 Feb 18. Epub 2019 Feb 18.

Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.

Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect humans, with IAV and IBV causing the most severe disease. CD8 T cells confer cross-protection against IAV strains, however the responses of CD8 T cells to IBV and ICV are understudied. We investigated the breadth of CD8 T cell cross-recognition and provide evidence of CD8 T cell cross-reactivity across IAV, IBV and ICV. Read More

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http://www.nature.com/articles/s41590-019-0320-6
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http://dx.doi.org/10.1038/s41590-019-0320-6DOI Listing
February 2019
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Quantifying in situ adaptive immune cell cognate interactions in humans.

Nat Immunol 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, USA.

Two-photon excitation microscopy (TPEM) has revolutionized the understanding of adaptive immunity. However, TPEM usually requires animal models and is not amenable to the study of human disease. The recognition of antigen by T cells requires cell contact and is associated with changes in T cell shape. Read More

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http://dx.doi.org/10.1038/s41590-019-0315-3DOI Listing
February 2019

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development.

Nat Struct Mol Biol 2019 Feb 18. Epub 2019 Feb 18.

Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Germ cells manifest a unique gene expression program and regain totipotency in the zygote. Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells during spermatogenesis. We show that the highly compartmentalized 3D chromatin organization characteristic of interphase nuclei is attenuated in meiotic prophase. Read More

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http://dx.doi.org/10.1038/s41594-019-0189-yDOI Listing
February 2019

Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis.

Nat Genet 2019 Feb 18. Epub 2019 Feb 18.

Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX, USA.

Streptococcus pyogenes causes 700 million human infections annually worldwide, yet, despite a century of intensive effort, there is no licensed vaccine against this bacterium. Although a number of large-scale genomic studies of bacterial pathogens have been published, the relationships among the genome, transcriptome, and virulence in large bacterial populations remain poorly understood. We sequenced the genomes of 2,101 emm28 S. Read More

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http://dx.doi.org/10.1038/s41588-018-0343-1DOI Listing
February 2019

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4 T cells from ART-suppressed individuals.

Nat Commun 2019 Feb 18;10(1):814. Epub 2019 Feb 18.

Centre de Recherche du CHUM, Montréal, H2X0A9, QC, Canada.

HIV persists in latently infected CD4 T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Read More

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http://dx.doi.org/10.1038/s41467-019-08798-7DOI Listing
February 2019

Adenosine deaminase-1 delineates human follicular helper T cell function and is altered with HIV.

Nat Commun 2019 Feb 18;10(1):823. Epub 2019 Feb 18.

Department of Medicine, Division of Infectious Diseases and HIV Medicine, Drexel University, Philadelphia, 19102, PA, USA.

Follicular helper T cells (Tfh) play critical roles instructing, and initiating T-cell dependent antibody responses. The underlying mechanisms that enhance their function is therefore critical for vaccine development. Here we apply gene array analysis identifying adenosine deaminase (ADA) as a key molecule that delineates a human Tfh helper program in proliferating circulating Tfh (cTfh) cells and Germinal Centers Tfh (GC-Tfh). Read More

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http://dx.doi.org/10.1038/s41467-019-08801-1DOI Listing
February 2019

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.

Nat Commun 2019 Feb 18;10(1):798. Epub 2019 Feb 18.

Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.

The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver immunizations to the sublingual and buccal (SL/B) tissue of rhesus macaques. Needle-free SL/B vaccination with modified vaccinia Ankara (MVA) and a recombinant trimeric gp120 protein generates strong vaccine-specific IgG responses in serum as well as vaginal, rectal and salivary secretions. Read More

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http://dx.doi.org/10.1038/s41467-019-08739-4DOI Listing
February 2019

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response.

Nat Commun 2019 Feb 18;10(1):821. Epub 2019 Feb 18.

Department of Medicine, Division of Hematology/Oncology, Weill Cornell Medicine, New York, NY, 10021, USA.

lncRNAs make up a majority of the human transcriptome and have key regulatory functions. Here we perform unbiased de novo annotation of transcripts expressed during the human humoral immune response to find 30% of the human genome transcribed during this process, yet 58% of these transcripts manifest striking differential expression, indicating an lncRNA phylogenetic relationship among cell types that is more robust than that of coding genes. We provide an atlas of lncRNAs in naive and GC B-cells that indicates their partition into ten functionally categories based on chromatin features, DNase hypersensitivity and transcription factor localization, defining lncRNAs classes such as enhancer-RNAs (eRNA), bivalent-lncRNAs, and CTCF-associated, among others. Read More

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http://dx.doi.org/10.1038/s41467-019-08679-zDOI Listing
February 2019

Comb sign in a patient with ankylosing spondylitis.

Indian J Med Res 2018 Dec;148(6):761-762

Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.

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http://dx.doi.org/10.4103/ijmr.IJMR_1256_17DOI Listing
December 2018

Bullous Fixed Drug Eruption Caused by Etoricoxib Confirmed by Patch Testing.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Serviço de Imunoalergologia, Centro Hospitalar Universitário São João, Porto, Portugal.

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http://dx.doi.org/10.1016/j.jaip.2019.01.032DOI Listing
February 2019

Severe Necrotic Reaction to 23-Valent Polysaccharide Pneumococcal Vaccine in a Patient With STAT3 Deficiency.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatric Infectious Diseases and Immunology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2019.01.033DOI Listing
February 2019

Integral Hematologic Indices in the Evaluation of the Immunologic Reactivity of the Organism in a Patient With Complication of Type 1 Diabetes Mellitus: A Case of Diabetic Retinopathy After Autologous Mesenchymal Stem Cell Transplant.

Exp Clin Transplant 2019 Jan;17(Suppl 1):234-235

From the Department of Ophthalmology, the National Scientific Medical Research Center, Astana, Kazakhstan.

The search continues for pathogenetically effective measures in autoimmune processes for a number of complications of type 1 diabetes mellitus, in particular, diabetic retinopathy. However, there are few studies of the prognostic and therapeutic values of the systemic autoimmune response in this pathology after transplant of autologous mesenchymal stem cells. Here, we present a 40-year-old patient with complications of type 1 diabetes mellitus (diabetic retinopathy) after mesenchymal stem cell transplant. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P99DOI Listing
January 2019

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019

Counter-regulation of regulatory T cells by autoreactive CD8 T cells in rheumatoid arthritis.

J Autoimmun 2019 Feb 16. Epub 2019 Feb 16.

Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, 00161, Rome, Italy; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, 00161, Rome, Italy; Istituto Pasteur - Fondazione Cenci Bolognetti, 00185, Rome, Italy. Electronic address:

The mechanisms whereby autoreactive T cells escape peripheral tolerance establishing thus autoimmune diseases in humans remain an unresolved question. Here, we demonstrate that autoreactive polyfunctional CD8 T cells recognizing self-antigens (i.e. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.02.001DOI Listing
February 2019

Methods for collection, handling, and analysis of sea urchin coelomocytes.

Methods Cell Biol 2019 9;150:357-389. Epub 2019 Jan 9.

Stem Cell Institute, School of Medicine, and the Hopkins Marine Station, Stanford University, Stanford, CA, United States.

Sea urchin coelomocytes can be collected in large numbers from adult sea urchins of the species, Strongylocentrotus purpuratus, which typically has 12-40mL of coelomic fluid. Coelomocytes are used for analysis of immune reactions and immune gene expression in addition to basic functions of cells, in particular for understanding structure and modifications of the cytoskeleton in phagocytes. The methods described here include coelomocyte isolation, blocking the clotting reaction, establishing and maintaining primary cultures, separation of different types of coelomocytes into fractions, processing live coelomocytes for light microscopy, fixation and staining for light and electron microscopy, analysis of coelomocyte populations by flow cytometry, and sorting single cells for more detailed follow-up analyses including transcriptomics or genomic characteristics. Read More

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http://dx.doi.org/10.1016/bs.mcb.2018.11.009DOI Listing
January 2019

Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity.

Adv Rheumatol 2019 Feb 18;59(1). Epub 2019 Feb 18.

Molecular immunology research center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial arthritis. The genetic-environmental factors seem to be involved in the pathogenesis of the disease and the disease debilitates patients during the most productive stages of their lives. The aim of this study was to examine the relationships between two environmental factors, diet and air pollution with disease activity and functional impairment in AS. Read More

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http://dx.doi.org/10.1186/s42358-019-0051-2DOI Listing
February 2019

Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar.

Parasit Vectors 2019 Feb 18;12(1):83. Epub 2019 Feb 18.

Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, 110122, Liaoning, China.

Background: The malaria burden of Myanmar still remains high within the Greater Mekong Subregion of Southeast Asia. An important indicator of progress towards malaria elimination is the prevalence of parasite infections in endemic populations. Information about malaria epidemiology is mostly derived from reports of confirmed acute malaria cases through passive case detection, whereas the prevalence of baseline subclinical malaria infections is much less known. Read More

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http://dx.doi.org/10.1186/s13071-019-3330-1DOI Listing
February 2019

What Affects Postoperative Sinusitis and Implant Failure after Dental Implant: A Meta-analysis.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819829747. Epub 2019 Feb 19.

1 Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Chonbuk National University, Jeonju, Republic of Korea.

Objective: The dental implant is an innovative instrument that enables the edentulous patient to chew. Many factors have a bearing on the success of dental implantation. There are also many complications after dental implantation. Read More

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http://dx.doi.org/10.1177/0194599819829747DOI Listing
February 2019

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program.

Cancer Res Treat 2019 Feb 19. Epub 2019 Feb 19.

National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement national cancer screening program in Korea.

Methods: Multidisciplinary expert committee was comprised to develop a standardized protocol forKorean Lung Cancer Screening Project (K-LUCAS). Read More

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http://dx.doi.org/10.4143/crt.2018.464DOI Listing
February 2019

Phytochemical profile of Syzygium formosum (Wall.) Masam leaves using HPLC-PDA-MS/MS and a simple HPLC-ELSD method for quality control.

J Pharm Biomed Anal 2019 Feb 11;168:1-12. Epub 2019 Feb 11.

College of Pharmacy, Chungnam National University, Daejeon 3414, South Korea. Electronic address:

Syzygium formosum (SF) leaves have been used for thousands of years in traditional Vietnamese medicine for the treatment of allergy or skin rash. However, the role of the phytochemical profile of SF leaves on their activities is poorly understood. Additionally, there is currently no quality control method for this herbal material, which is required by the pharmaceutical industry. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.014DOI Listing
February 2019

The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Patient registries are instrumental for clinical research in rare diseases. They help to achieve a sufficient sample size for epidemiological and clinical research and to assess the feasibility of clinical trials. The European Society for Immunodeficiencies (ESID) registry currently comprises information on >25,000 patients with inborn errors of immunity (IEI). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.004DOI Listing
February 2019

AAAAI/ACAAI subcutaneous immunotherapy (SCIT) surveillance study (2013-2017): fatalities, infections, delayed reactions and use of epinephrine auto-injectors.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Immunology, Allergy, and Rheumatology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; and Bernstein Clinical Research Center, Cincinnati, Ohio.

Background: SCIT is highly effective but safety risks exist.

Objective: The aims of this study were to: 1) identify clinical practices that could influence fatal and non-fatal systemic allergic reactions (SRs) to SCIT; and 2) identify SCIT-associated infections.

Methods: From 2008-2016, 27-51% of AAAAI/ACAAI members completed an annual survey of SCIT-related SRs of varying severity. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.058DOI Listing
February 2019

Do youth ask asthma providers the questions they want to ask?

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Cecil G. Sheps, Center for Health Services Research, University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1016/j.jaip.2019.02.005DOI Listing
February 2019