485,775 results match your criteria Allergy & rhinology Providence R.I.[Journal]


Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model.

J Antimicrob Chemother 2020 May 28. Epub 2020 May 28.

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo, Buffalo, NY, USA.

Background: MBL-producing strains of Enterobacteriaceae are a major public health concern. We sought to define optimal combination regimens of ceftazidime/avibactam with aztreonam in a hollow-fibre infection model (HFIM) of MBL-producing strains of Escherichia coli and Klebsiella pneumoniae.

Methods: E. Read More

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http://dx.doi.org/10.1093/jac/dkaa197DOI Listing

The Link between Asthma and Bronchiectasis: State of the Art.

Respiration 2020 May 28:1-14. Epub 2020 May 28.

Respiratory Medicine Unit, A.O.U. "Policlinico-Vittorio Emanuele," University of Catania, Catania, Italy.

The nonrecognition of asthma-associated comorbidities is often responsible for the therapeutic failure and the worsening of symptoms, and it is associated with frequent exacerbations, higher disease severity, and increased health costs. Bronchiectasis, one of the most frequent asthma-associated comorbidities, can increase airways inflammation and exacerbation rates and cause respiratory functional impairment. The aim of this article is to review the interactions between bronchiectasis and asthma, in order to better identify patients in the overlap between the 2 diseases and to select an "ad hoc" therapy. Read More

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http://dx.doi.org/10.1159/000507228DOI Listing

The pre-CT checklist: A simple tool to improve workflow and patient safety in an outpatient CT setting.

Clin Imaging 2020 May 18;66:101-105. Epub 2020 May 18.

Johns Hopkins Hospital Department of Radiology and Radiological Science, Baltimore, MD 21287, United States of America. Electronic address:

Purpose: We aim to share our experience with implementation of a simple checklist to improve workflow and safety in patients scheduled for outpatient CT.

Methods: After identification of several recurrent problems leading to study delays or cancellation, a pre-CT checklist to be used by designated CT technologist in advance of patients' scheduled appointment was designed with input from CT technologists, radiologists, schedulers and nurses.

Results: Implementation of the checklist led to further actions in 25. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.014DOI Listing

Homocysteine as a potential predictor of cardiovascular risk in patients with COVID-19.

Med Hypotheses 2020 May 21;143:109859. Epub 2020 May 21.

Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, Division of Clinical Pathology, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2020.109859DOI Listing

Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy.

Prog Neuropsychopharmacol Biol Psychiatry 2020 May 25:109975. Epub 2020 May 25.

Faculty of Pharmacy, Department of Pharmacology, University of Belgrade, Belgrade, Serbia.

Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatment of symptoms of neuropathy and concomitant depression. We examined the effects of vortioxetine, a novel antidepressant with unique mechanism of action, on pain hypersensitivity and depression-like behavior in oxaliplatin-induced neuropathy model in mice (OIPN). Read More

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http://dx.doi.org/10.1016/j.pnpbp.2020.109975DOI Listing

Abstracts of Presentations from the 2020 Trans-Agency Scientific Meeting on Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Ocular Chemical Toxicity, 25-26 February, Bethesda, Maryland.

Toxicol Lett 2020 May 25. Epub 2020 May 25.

Department of Defense, United States Army Medical Research Institute of Chemical Defense (USAMRICD), 2900 Ricketts Point Road, Aberdeen Proving Ground, Maryland, 21010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.toxlet.2020.05.026DOI Listing

Delivery of polysaccharides from Ophiopogon japonicus (OJPs) using OJPs/chitosan/whey protein co-assembled nanoparticles to treat defective intestinal epithelial tight junction barrier.

Int J Biol Macromol 2020 May 25. Epub 2020 May 25.

Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Department of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. Electronic address:

The polysaccharides from Ophiopogon japonicus (OJPs) were known to have protective effects against diabetes, and cardiovascular and chronic inflammatory diseases. However, OJPs were poorly absorbed after oral administration, resulting in limited efficacy because of the low bioavailability. In this study, OJPs extracted and fractionated from Ophiopogon japonicus were used to prepare OJPs/chitosan (CS)/whey protein (WP) co-assembled nanoparticles. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.151DOI Listing

COVID-19-associated hyperviscosity: a link between inflammation and thrombophilia?

Lancet 2020 May 25. Epub 2020 May 25.

Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA30322, USA.

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http://dx.doi.org/10.1016/S0140-6736(20)31209-5DOI Listing

Isavuconazole is as effective as and better tolerated than voriconazole for antifungal prophylaxis in lung transplant recipients.

Clin Infect Dis 2020 May 28. Epub 2020 May 28.

Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh.

Background: Invasive fungal infections (IFIs) are common following lung transplantation. Isavuconazole is unstudied as prophylaxis in organ transplant recipients. We compared effectiveness and tolerability of isavuconazole and voriconazole prophylaxis in lung transplant recipients. Read More

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http://dx.doi.org/10.1093/cid/ciaa652DOI Listing

The benefits of latex-free gloves in the operating room environment.

Br J Nurs 2020 May;29(10):570-576

Consultant Burns and Plastic Surgeon, University Hospitals Birmingham, NHS Foundation Trust.

Sterile protective gloves are used to reduce the risk of infection for patients and clinicians in all healthcare settings. This is particularly important in operating theatres, where surgical site infection is a common and serious complication for perioperative patients. These gloves have traditionally been made from natural rubber latex and dusted with cornstarch powder. Read More

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http://dx.doi.org/10.12968/bjon.2020.29.10.570DOI Listing

When doing the right thing is wrong: Drug efflux pumps in steroid-resistant nephrotic syndrome.

Int J Rheum Dis 2020 May;23(5):611-612

Section of Rheumatology, Allergy and Immunology, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/1756-185X.13818DOI Listing

Assessment of Maternal Glycemia and Newborn Size Among Pregnant Women Who Use Wood Stoves in Northern New England.

JAMA Netw Open 2020 May 1;3(5):e206046. Epub 2020 May 1.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1001/jamanetworkopen.2020.6046DOI Listing

RSV neutralizing antibodies at birth predict protection from RSV illness in infants in the first three months of life.

Clin Infect Dis 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, USA.

Background: Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first six months of life. Placentally-transferred antibodies can prevent severe RSV illness, and maternal immunization may reduce illness in young infants. Identifying protective antibody levels will facilitate the advancement of vaccine candidates and maternal immunization. Read More

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http://dx.doi.org/10.1093/cid/ciaa648DOI Listing

Comorbidity and early death in Danish stage I lung cancer patients - an individualised approach.

Acta Oncol 2020 May 28:1-8. Epub 2020 May 28.

Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

Comorbidity is an important prognostic marker and a treatment indicator for lung cancer patients. Register-based studies often describe the burden of comorbidity by the Charlson comorbidity index (CCI) based on hospital discharge data. We assessed the association between somatic and psychiatric comorbidity and death within one year in early lung cancer and, furthermore, the burden of comorbidity according to treatment type. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1764096DOI Listing

Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925978

SUNY Upstate Medical University, Syracuse, NY, USA.

Idiopathic acute eosinophilic pneumonia (AEP) is a very rare disease with fewer than 200 cases reported. It has been hypothesized to be a hypersensitivity reaction to an unidentified antigen. The clinical presentation typically involves fever, nonproductive cough, shortness of breath, and bibasilar inspiratory crackles within the first week of antigen exposure. Read More

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http://dx.doi.org/10.1177/2324709620925978DOI Listing

Functional Improvements of Speech, Feeding, and Sleep After Lingual Frenectomy Tongue-Tie Release: A Prospective Cohort Study.

Clin Pediatr (Phila) 2020 May 28:9922820928055. Epub 2020 May 28.

University of London, London, UK.

Recent studies suggest that speech, solid feeding, and sleep difficulties may be linked to restricted tongue function. Children with tongue restrictions and speech, feeding, and sleep issues underwent lingual frenectomies with a CO laser, paired with myofunctional exercises. Questionnaires were completed before, 1 week after, and 1 month following treatment. Read More

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http://dx.doi.org/10.1177/0009922820928055DOI Listing

Obesity is a Risk Factor for Exercise-Induced Bronchospasm in Asthmatic Adolescents.

Pediatr Pulmonol 2020 May 28. Epub 2020 May 28.

Health Sciences Post-graduation Program, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.

Introduction: Exercise-induced bronchospasm (EIB) is common in young asthmatics and obesity is becoming epidemic in this population. Both conditions can give rise or worsen respiratory symptoms upon exercise and may interfere with recreational and sports activities.

Objective: To investigate the association between obesity and the risk and severity of EIB in asthmatic children and adolescents. Read More

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http://dx.doi.org/10.1002/ppul.24875DOI Listing

Adding a second skin prick test reading and modifying the Cut-off for Beta-lactam-specific IgE enhances the sensitivity in the routine diagnostic work-up for immediate Beta-lactam-hypersensitivity.

Contact Dermatitis 2020 May 28. Epub 2020 May 28.

Allergy-clinic of the Department of Dermatology, University Hospital of Erlangen, Germany.

Background: Beta-lactam (BL)-antibiotics are the most frequent reason for drug-induced hypersensitivity reactions. Since they are more efficient, less toxic and less costly than other antibiotics, confirmation or exclusion of BL-allergy is worthwhile. However, allergy tests for drug-allergies are often false-negative. Read More

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http://dx.doi.org/10.1111/cod.13622DOI Listing

Comparison of Treatment Options for Refractory Opioid Use Disorder in the United States and Canada: a Narrative Review.

J Gen Intern Med 2020 May 27. Epub 2020 May 27.

Grayken Center for Addiction, Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Department of Medicine, Boston Medical Center, Boston, MA, USA.

Amidst the opioid overdose crisis, there are increased efforts to expand access to medications for opioid use disorder (MOUD). Hospitalization for the complications of substance use in the United States (US) provides an opportunity to initiate methadone, buprenorphine, and extended release naltrexone and link high-risk, not otherwise engaged, patients into outpatient care. However, treatment options for patients are quickly exhausted when these medications are not desired, tolerated, or beneficial. Read More

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http://dx.doi.org/10.1007/s11606-020-05920-0DOI Listing

Any unique image biomarkers associated with COVID-19?

Eur Radiol 2020 May 28. Epub 2020 May 28.

Department of Radiology, Xi'an Jiaotong University The First Affiliated Hospital, Xi'an, China.

Objective: To define the uniqueness of chest CT infiltrative features associated with COVID-19 image characteristics as potential diagnostic biomarkers.

Methods: We retrospectively collected chest CT exams including n = 498 on 151 unique patients RT-PCR positive for COVID-19 and n = 497 unique patients with community-acquired pneumonia (CAP). Both COVID-19 and CAP image sets were partitioned into three groups for training, validation, and testing respectively. Read More

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http://dx.doi.org/10.1007/s00330-020-06956-wDOI Listing

Clinical and radiological characteristics of e-cigarette or vaping product use associated lung injury.

Emerg Radiol 2020 May 28. Epub 2020 May 28.

Department of Pulmonology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Purpose: E-cigarette or vaping product use associated lung injury (EVALI) has received national attention as an epidemic resulting in cases of significant morbidity and mortality. We aim to present the clinical and imaging findings in adolescents with pulmonary symptoms from suspected EVALI.

Methods: Chest radiographs and CTs of adolescents (< 19 years) with acute pulmonary symptoms and history of vaping were reviewed by two radiologists in consensus. Read More

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http://dx.doi.org/10.1007/s10140-020-01796-zDOI Listing

Metformin use reduced the risk of stomach cancer in diabetic patients in Korea: an analysis of Korean NHIS-HEALS database.

Gastric Cancer 2020 May 27. Epub 2020 May 27.

Department of Family Medicine, Chungbuk National University Hospital, 776 1-Soonwhan-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.

Background: Diabetes mellitus (DM) increases atherosclerotic cardiovascular complications and cancer risks. Stomach cancer is the most common cancer in Korea. Although the survival rate of stomach cancer has improved, the disease burden is still high. Read More

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http://dx.doi.org/10.1007/s10120-020-01085-1DOI Listing

Effect of Functional Endoscopic Sinus Surgery on Outcomes in Chronic Rhinosinusitis​.

Curr Allergy Asthma Rep 2020 May 27;20(7):27. Epub 2020 May 27.

Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK.

Purpose Of Review: Chronic rhinosinusitis (CRS) has a significant negative impact on quality of life (QoL). Surgical treatment of CRS is indicated when medical therapy fails to achieve adequate symptom control. This review summarizes the latest information on the outcomes after endoscopic sinus surgery (ESS) with relation to QoL, revision rates, olfaction, absenteeism, asthma control, use of systemic medications, quality of sleep and complications. Read More

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http://dx.doi.org/10.1007/s11882-020-00932-6DOI Listing

Self-healing juvenile cutaneous mucinosis, a sclerodermoid disorder simulating juvenile dermatomyositis: a case-based review.

Rheumatol Int 2020 Apr 22. Epub 2020 Apr 22.

Department of Pediatric Clinical Immunology and Rheumatology, Allergy Immunology Unit, Postgraduate Institute of Medical Education and Research, Advanced Pediatric Center, Chandigarh, 160012, India.

Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare childhood disease with characteristic cutaneous and rheumatic manifestations. Cutaneous manifestations include a combination of nodules affecting peri-articular (especially interphalangeal joints) and head and neck areas; and linearly arranged ivory white papules over an erythematous indurated skin. Despite a benign course, an abrupt onset of symptoms with extensive cutaneous involvement often leads to parental anxiety, overenthusiastic evaluation and sometimes aggressive treatment. Read More

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http://dx.doi.org/10.1007/s00296-020-04578-5DOI Listing

Chronic cough related to the upper airway cough syndrome: one entity but not always the same.

Eur Arch Otorhinolaryngol 2020 May 27. Epub 2020 May 27.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, Warsaw, Poland.

Purpose: Upper airway cough syndrome (UACS), described as chronic cough (CC) associated with allergic (AR), non-allergic rhinitis (NAR) or chronic rhinosinusitis (CRS), is one of the major causes of CC. We aimed to characterize a cohort of UACS patients with special attention to differences between patients with AR and NAR.

Methods: A prospective analysis of clinical data of patients, diagnosed with UACS between 2015 and 2018. Read More

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http://dx.doi.org/10.1007/s00405-020-06071-yDOI Listing

Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure.

Mol Ther Methods Clin Dev 2020 Jun 3;17:1048-1060. Epub 2020 May 3.

American Gene Technologies International, Rockville, MD, USA.

Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a cell and gene therapy to reconstitute HIV-specific CD4 T cells and prevent their destruction by HIV. Antigen-specific CD4 T cells will provide helper functions to support antiviral cytotoxic T lymphocyte (CTL) function and the production of virus-specific antibodies. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240062PMC

Colchicine's effects on metabolic and inflammatory molecules in adults with obesity and metabolic syndrome: results from a pilot randomized controlled trial.

Int J Obes (Lond) 2020 May 27. Epub 2020 May 27.

Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892-1103, USA.

Objective: Recent clinical trials have demonstrated that colchicine may have metabolic and cardiovascular and benefits in at-risk patients; however, the mechanisms through which colchicine may improve outcomes are still unclear. We sought to examine colchicine's effects on circulating inflammatory and metabolic molecules in adults with obesity and metabolic syndrome (MetS).

Methods: Blood samples were collected pre- and post-intervention during a double-blind randomized controlled trial in which 40 adults with obesity and MetS were randomized to colchicine 0. Read More

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http://dx.doi.org/10.1038/s41366-020-0598-3DOI Listing

The evaluation of the desensitization effect of a desensitizing agent and desensitizing toothpastes in vitro.

Dent Mater J 2020 May 27. Epub 2020 May 27.

Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology.

This study was evaluating how three desensitizing toothpastes used at home influence the effect associated with desensitizing agents after application in the clinic. Fifty dentine disks measure it permeability and 32 dentine disks with similar permeability levels were selected. Following Dental desensitizer treatment, dentine disks were randomly divided into three subgroups (n=10) that received applications of three toothpastes, respectively. Read More

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http://dx.doi.org/10.4012/dmj.2019-164DOI Listing

High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D.

Proc Natl Acad Sci U S A 2020 May 27. Epub 2020 May 27.

Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Rockville, MD 20852;

Complete cancer regression occurs in a subset of patients following adoptive T cell therapy (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success rate presents a great challenge to broader clinical application. To provide insight into TIL-based immunotherapy, we studied a successful case of ACT where regression was observed against tumors carrying the hotspot mutation G12D in the KRAS oncogene. Read More

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http://dx.doi.org/10.1073/pnas.1921964117DOI Listing

Transfer of monoclonal antibodies into breastmilk in neurologic and non-neurologic diseases.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 27;7(4). Epub 2020 May 27.

From the Department of Neurology (S.C.L., A.A., K.M.K., A.R., R.B.), School of Medicine, University of California San Francisco; Department of Neurology (S.C.L., A.A., K.M.K., A.R., R.B.), Weill Institute for Neurosciences, University of California San Francisco; Department of Pediatrics (M.J.D.), Division of Allergy, Immunology and Blood and Marrow Transplant, University of California San Francisco, CA; Department of Pediatrics (T.H.), Texas Tech University School of Medicine, Amarillo, TX; Department of Gastroenterology (U.M.), University of California San Francisco; Department of Pediatrics (E.E.R.), University of California San Francisco; and Department of Obstetrics (M.G.R.), Gynecology, and Reproductive Sciences, University of California San Francisco, CA.

Objective: To review currently available data on the transfer of monoclonal antibodies (mAbs) in the breastmilk of women receiving treatment for neurologic and non-neurologic diseases.

Methods: We systematically searched the medical literature for studies referring to 19 selected mAb therapies frequently used in neurologic conditions and "breastmilk," "breast milk," "breastfeeding," or "lactation." From an initial list of 288 unique references, 29 distinct full-text studies met the eligibility criteria. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000769DOI Listing

Minimising the environmental impact of inhaled therapies.

Eur Respir J 2020 May 27;55(5). Epub 2020 May 27.

Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1183/13993003.00721-2020DOI Listing

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.

Sci Transl Med 2020 May;12(545)

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3026, USA.

Eosinophilic esophagitis (EoE) is a chronic, food antigen-driven, inflammatory disease of the esophagus and is associated with impaired barrier function. Evidence is emerging that loss of esophageal expression of the serine peptidase inhibitor, kazal type 7 (SPINK7), is an upstream event in EoE pathogenesis. Here, we provide evidence that loss of mediates its pro-EoE effects via kallikrein 5 (KLK5) and its substrate, protease-activated receptor 2 (PAR2). Read More

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http://dx.doi.org/10.1126/scitranslmed.aaz7773DOI Listing

Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis.

Sci Transl Med 2020 May;12(545)

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

It is challenging to quickly diagnose slowly progressing diseases. To prioritize multiple related diagnoses, we developed G-PROB (Genetic Probability tool) to calculate the probability of different diseases for a patient using genetic risk scores. We tested G-PROB for inflammatory arthritis-causing diseases (rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathy, psoriatic arthritis, and gout). Read More

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http://dx.doi.org/10.1126/scitranslmed.aay1548DOI Listing

Evaluation of a Novel Semi-quantitative Cryptococcal Antigen Lateral Flow Assay in Patients with Advanced HIV Disease.

J Clin Microbiol 2020 May 27. Epub 2020 May 27.

Botswana National Health Laboratory, Gaborone, Botswana.

Higher cryptococcal antigen (CrAg) titers are strongly associated with mortality risk in individuals with HIV-associated cryptococcal disease. Rapid tests to quantify CrAg level may provide important prognostic information and enable treatment stratification. We performed a laboratory-based validation of the semi-quantitative IMMY CrAgSQ assay against the current gold-standard CrAg tests. Read More

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http://dx.doi.org/10.1128/JCM.00441-20DOI Listing

Covid-19 related hospital admissions in the United States: needs and outcomes.

BMJ 2020 May 27;369:m2082. Epub 2020 May 27.

Center for Emergency Care Policy and Research, Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

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http://dx.doi.org/10.1136/bmj.m2082DOI Listing

Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors.

Behav Brain Res 2020 May 24:112714. Epub 2020 May 24.

Department of Pharmacology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan. Electronic address:

Previous studies have demonstrated that continuous substance P (SP) infusion into the rat striatum attenuated hind paw formalin-induced nociceptive behaviors and mechanical hypersensitivity via a neurokinin-1 (NK1) receptor dependent mechanism. However, whether there is a role of striatal infusion of SP on chronic, neuropathic pain has yet to be demonstrated. The present study investigated the effect of continuous SP infusion into the rat striatum using a reverse microdialysis method is antinociceptive in a rat model of chronic, mononeuropathic pain. Read More

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http://dx.doi.org/10.1016/j.bbr.2020.112714DOI Listing

Poor asthma control remains a risk factor for severe anaphylaxis.

J Pediatr 2020 May 24. Epub 2020 May 24.

University of Trieste, Department of Pediatrics, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1016/j.jpeds.2020.05.045DOI Listing

Allergy to beta-lactam antibiotics in children: Risk factors for a positive diagnostic work-up.

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Allergy and Clinical Immunology Department, Centro Hospitalar Universitário de S. João, Porto, Portugal.

Background: Allergy to beta-lactam (βL) antibiotics is highly reported in children, but rarely confirmed. Risk factors for a positive diagnostic work-up are scarce. The primary aim was to characterize the cases of children with confirmed βL allergy, investigating potential risk factors. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.005DOI Listing

Contact haptens in emollients marketed in two European countries (Poland and Spain).

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Department of Pediatric Respiratory Diseases and Allergy, The Medical University of Warsaw, Żwirki i Wigury 63A, PL-02-091 Warsaw, Poland. Electronic address:

Introduction And Objectives: Atopic dermatitis (AD) is the most common skin disease among pediatric patients, which affects up to 20% of children worldwide. Characterized by pruritus and eczema, it is also associated with improper skin barrier function and allergen sensitization. Here, we aimed to assess the presence of haptens in emollients marketed in two European countries: in Poland and Spain, as, firstly, these products are considered to be AD's basic therapy, and, secondly, frequent application of potent sensitizers on atopic skin may result in contact dermatitis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.002DOI Listing

Venom allergy and knowledge about anaphylaxis among beekeepers and their families.

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul, Turkey.

Background: Beekeepers and their families are at an increased risk of life-threatening anaphylaxis due to recurrent bee-sting exposures.

Objective: The aim of this study is to evaluate the demographic features, previous history of anaphylaxis among beekeepers and their family members, and their knowledge about the symptoms and management of anaphylaxis.

Methods: A standardized questionnaire was administered to beekeepers during the 6th International Beekeeping and Pine Honey Congress held in 2018, in Mugla, Turkey. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.008DOI Listing

Views among Malawian women about joining HIV prevention clinical trials when pregnant.

AIDS Res Ther 2020 May 27;17(1):27. Epub 2020 May 27.

Center for Bioethics and Department of Social Medicine, University of North Carolina at Chapel Hill, 333 S. Columbia Street, Campus Box 7240, Chapel Hill, NC, 27599, USA.

Background: The pressing need to expand the biomedical HIV prevention evidence base during pregnancy is now increasingly recognized. Women's views regarding participation in such trials and initiating PrEP while pregnant are critical to inform evolving policy and best practices aimed at responsibly expanding evidence-based access for this population.

Methods: We conducted 35 semi-structured interviews with reproductive-aged women in Malawi in the local language, Chichewa. Read More

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http://dx.doi.org/10.1186/s12981-020-00271-6DOI Listing

Readability of Printed Online Education Materials on Pituitary Tumors: Untangling a Web of Complexity.

Am J Rhinol Allergy 2020 May 27:1945892420927288. Epub 2020 May 27.

Indiana University School of Medicine, Indianapolis, Indiana.

Background: Patients are increasingly turning to the internet for health education. Due to the complex pathophysiology, clinic-diagnostic profile, and management spectrum of pituitary tumors, an evaluation of the readability of printed online education materials (POEMs) regarding this entity is warranted.

Objective: (1) To apply established readability assessment tools to internet search results on the topic of pituitary tumors. Read More

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http://dx.doi.org/10.1177/1945892420927288DOI Listing

Staphylococcus aureus, antibiotic resistance, and the interaction with human neutrophils.

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

National Institute of Allergy and Infectious Diseases Division of Intramural Research, 469049, Laboratory of Bacteriology, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana, United States, 59840;

Significance: Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The high burden of S. aureus among human and animal hosts, which includes asymptomatic carriage and infection, is coupled with a notorious ability of the microbe to become resistant to antibiotics. Read More

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http://dx.doi.org/10.1089/ars.2020.8127DOI Listing

Distinct functions of eosinophils in severe asthma with type 2 phenotype: clinical implications.

Korean J Intern Med 2020 May 29. Epub 2020 May 29.

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Asthma is commonly recognized as a heterogeneous condition with a complex pathophysiology. With advances in the development of multiple medications for patients with asthma, most asthma symptoms are well managed. Nevertheless, 5% to 10% of adult asthmatic patients (called severe asthma) are in uncontrolled or partially controlled status despite intensive treatment. Read More

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http://dx.doi.org/10.3904/kjim.2020.022DOI Listing

Natural History and Predictors of recovery in Children with Chronic Spontaneous Urticaria.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Limited data are available about the natural history of chronic spontaneous urticaria in children (CSU), and management guidelines are mostly extrapolated from evidence in adults.

Methods: The objective of this study was toevaluate the natural history of CSU in children and to identify predictors for remission. We performed an observational study, including patients aged 0 to 18 years with CSU diagnosed from January 2006 to July 2016. Read More

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http://dx.doi.org/10.1111/pai.13299DOI Listing

Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Bronchiolitis is the leading cause of infant hospitalizations in the U.S. Growing evidence supports the heterogeneity of bronchiolitis. Read More

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http://dx.doi.org/10.1111/pai.13296DOI Listing

Epithelial cell dysfunction, a major driver of asthma development.

Allergy 2020 May 27. Epub 2020 May 27.

University of Groningen, University Medical Center Groningen, Department of Pathology&Medical Biology GRIAC research Institute, Groningen, The Netherlands.

Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitization to allergens and pathogenesis of asthma. Read More

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http://dx.doi.org/10.1111/all.14421DOI Listing

Bioinformatics Analysis and Identification of Underlying Biomarkers Potentially Linking Allergic Rhinitis and Asthma.

Med Sci Monit 2020 May 27;26:e924934. Epub 2020 May 27.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND Rhinitis is the most common clinical manifestation of allergy, affecting more than 400 million people around the world. Rhinitis increases the risk of developing bronchial hyper-responsiveness and asthma. Previous studies have shown that rhinitis is closely related with the physiology, pathology, and pathogenesis of asthma. Read More

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http://dx.doi.org/10.12659/MSM.924934DOI Listing