463,631 results match your criteria Allergy & rhinology Providence R.I.[Journal]


[MASK (Mobile Airways Sentinel Network). ARIA's comprehensive solution for mobile app for the multimorbidity of allergic rhinitis and asthma].

Rev Alerg Mex 2019 Jan-Mar;66(1):140-146

Médica Sur, Centro de Excelencia en Asma y alergia, Ciudad de México, México.

The vast majority of patients with allergic rhinitis (AR) do not receive the proper management which is recommended by the guidelines, but they frequently self-medicate. MASK (Mobile Airways Sentinel Network) is an integral part of a project that is supported by the European Union against chronic diseases and focused on active and healthy aging. MASK represents the third phase of ARIA (Allergic Rhinitis and its Impact on Asthma), in which, by using a mobile application in a smart device, the objective is to guide the patient in the control of his/her multi-morbidity, AR and/or allergic conjunctivitis (AC) and/or asthma. Read More

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http://dx.doi.org/10.29262/ram.v66i1.578DOI Listing

[Anaphylaxis in a lactating infant who is allergic to cow's milk protein].

Rev Alerg Mex 2019 Jan-Mar;66(1):123-127

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Antioquia, Colombia.

Background: Allergy to cow's milk protein is a common problem in children. The clinical manifestations of the reactions that are mediated by IgE are varied and the anaphylactic reactions can be life-threatening.

Clinical Case: A girl at an age of four months and a half that, five minutes after consuming cereal with cow's milk, had rashes in the perioral area and extensive pruritic micropapular lesions associated with vomit and inspiratory stridor. Read More

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http://dx.doi.org/10.29262/ram.v66i1.350DOI Listing

Adverse immune reactions and non-immune medications for perioperative use.

Rev Alerg Mex 2019 Jan-Mar;66(1):99-114

Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México.

Reactions to medications can occur through a mechanism mediated by immunoglobulin or otherwise, not both. Drug allergy is a type of adverse reaction to the drug and comprises a range of hypersensitivity reactions mediated by different immunological mechanisms with diverse clinical manifestations. A rate of 3. Read More

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http://dx.doi.org/10.29262/ram.v66i1.541DOI Listing

[Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus].

Rev Alerg Mex 2019 Jan-Mar;66(1):38-43

Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.

Background: The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Objective: To determine the sensitivity and specificity of the epicutaneous patch test that has been modified for the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

Methods: An observational, interpretative, prolective, and transversal study. Read More

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http://dx.doi.org/10.29262/ram.v66i1.533DOI Listing

[Evaluation of diagnostic and management concepts of anaphylaxis in non-allergist physicians in Colombia].

Rev Alerg Mex 2019 Jan-Mar;66(1):18-26

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Background: Several reports show deficiencies in the knowledge of physicians about the diagnostic criteria and the treatment of anaphylaxis, a condition that can have fatal consequences.

Objective: To evaluate the knowledge of physicians in Colombia on the fundamental aspects of anaphylaxis in diagnosis and treatment.

Methods: Analytical cross-sectional study, carried out through a survey of 11 questions that evaluate clinical aspects of anaphylaxis, addressed to general practitioners and specialists in different health areas resident in Colombia. Read More

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http://dx.doi.org/10.29262/ram.v66i1.524DOI Listing

[Results and limitations of epidemiological studies on food allergy. Focus on tropical countries].

Rev Alerg Mex 2019 Jan-Mar;66(1):9-17

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Allergy and food atopy are a consequence of immune responses unadapted to antigens mediated by common and otherwise harmless foods. Food allergy (AF) occurs frequently in children under three years of 3 to 15%, as well as in people over 6 to 8%. AF may be mediated by immunoglobulin E or cellular mechanisms and may present with a wide variety of symptoms in the skin, respiratory and gastrointestinal tracts. Read More

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http://dx.doi.org/10.29262/ram.v66i1.340DOI Listing

[Allergy to food in adults with allergic respiratory diseases: prevalence and clinical manifestations].

Rev Alerg Mex 2019 Jan-Mar;66(1):1-8

Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, México.

Background: Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.

Objective: To determine the prevalence of food allergy in patients with allergic rhinitis and asthma; as well as the foods and symptoms most related to said problem.

Methods: Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. Read More

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http://dx.doi.org/10.29262/ram.v66i1.400DOI Listing

Parent and child perception of quality of life in a randomized controlled peanut oral immunotherapy trial.

Pediatr Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.

Background: Improved quality of life (QoL) after oral immunotherapy (OIT) in peanut allergic children is often reported by their parents, while the child's perspective is less clear.

Objective: We aimed to explore if two years of OIT improved QoL in children with peanut allergy and to identify factors influencing change in QoL.

Methods: In the open labelled TAKE-AWAY peanut OIT trial including children with anaphylaxis to peanuts, 57 were randomized to OIT and 20 to observation. Read More

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http://dx.doi.org/10.1111/pai.13066DOI Listing

Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Asthma and allergic rhinitis (AR) are chronic inflammatory diseases of airway and affect the disease severity each other.

Objective: We performed this study to examine whether nasal saline irrigation (NSI) improves bronchial hyperresponsiveness and clinical parameters in children with asthma and allergic rhinitis (AR).

Methods: We enrolled 20 children with AR and asthma aged between 6-18 years. Read More

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http://dx.doi.org/10.12932/AP-070918-0403DOI Listing

Natural resolution of non-anaphylactic shrimp allergy in patients diagnosed 10 years earlier by oral food challenge.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Shrimp allergy is considered a lifelong condition. The natural resolution of shrimp allergy is not well studied.

Objective: To investigate the natural resolution of shrimp allergy among a cohort of patients diagnosed with shrimp allergy 10 years earlier by oral shrimp challenge. Read More

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http://dx.doi.org/10.12932/AP-080119-0470DOI Listing

Elevated levels of periostin and TGF-β1 in the bronchoalveolar lavage fluid of patients with idiopathic eosinophilic pneumonia.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory Medicine, Kawasaki Medical School, Okayama.

Background: Periostin is induced in bronchial epithelial cells and fibroblasts by various stimuli including interleukin (IL)13 and transforming growth factor (TGF)-β1, and is involved in allergic diseases such as asthma and atopic dermatitis, playing an important role in tissue remodeling and fibrosis. The role of periostin in the pathogenesis of eosinophilic lung diseases, however, is unclear.

Objective: To examine the contribution of periostin to eosinophilic inflammation of the lung in humans, we evaluated periostin, IL-13, and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). Read More

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http://dx.doi.org/10.12932/AP-111018-0414DOI Listing

Food allergy in nursery children of Kawasaki city, Japan.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

The Health Administration Committee of Nursery in Kawasaki city.

Background: Food allergies are often life threatening. In order to establish appropriate food allergy measures in nursery children, it is important to analyze local epidemiological data on the food allergy prevalence in nursery children. However, no such data are currently available for the city of Kawasaki, Japan. Read More

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http://dx.doi.org/10.12932/AP-151118-0439DOI Listing

The clinical significance of antinuclear antibodies and specific autoantibodies in juvenile and adult systemic lupus erythematosus patients.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Center of Excellence in Immunology and Immune-mediated Diseases, Department of Microbiology.

Background: Juvenile systemic lupus erythematosus (JSLE) and adult SLE (ASLE) patients present with different clinical manifestations, but it is unknown if there are differences in their antinuclear autoantibody (ANA) profiles or if staining patterns are associated with specific autoantibodies and clinical manifestations.

Objective: To determine whether distinct types and numbers of ANA-staining patterns are associated with specific autoantibodies and clinical manifestations in JSLE and ASLE patients.

Methods: A retrospective study was performed in Thai children (n = 146) and adults (n = 180) diagnosed with SLE using the Systemic Lupus International Collaborating Clinics classification criteria. Read More

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http://dx.doi.org/10.12932/AP-211218-0465DOI Listing

A study on the effect of nutrient intake on the body mass index of mothers of children with food allergies.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Osaka Prefecture Medical Center for Respiratory and Allergic Diseases, 3-7-1, Habikino, Habikino, Osaka Prefecture, 583-8588, Japan.

Background: No previous studies have reported the effect of the presence of children with food allergies (FAs) on the diet and body mass index (BMI) of mothers. Therefore, we conducted a dietary survey and considered nutrients that influenced BMI of mothers.

Objective: Subjects included 554 mothers-305 mothers of children with FAs (FA mothers; aged 38. Read More

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http://dx.doi.org/10.12932/AP-260718-0377DOI Listing

Association of HLA genotypes with Beta-lactam antibiotic hypersensitivity in children.

Asian Pac J Allergy Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 10400.

Background: Beta-lactam (BL) antibiotics hypersensitivity is common in children. Clinical manifestation of BL hypersensitivity varies from mild to severe cutaneous adverse drug reactions (SCARs).

Objective: To determine the association of HLA genotype and BL hypersensitivity and the prevalence of true drug allergy in patients with history of BL hypersensitivity. Read More

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http://dx.doi.org/10.12932/AP-271118-0449DOI Listing

Validation of a rhinologic virtual surgical simulator for performing a Draf 3 endoscopic frontal sinusotomy.

Int Forum Allergy Rhinol 2019 Apr 23. Epub 2019 Apr 23.

Department of Otolaryngology-Head & Neck Surgery, Stanford University, Stanford, CA.

Background: We recently introduced a patient-specific rhinologic virtual surgical environment (VSE) that has shown potential for surgical rehearsal of various skull base lesions. Our aim in this study was to validate the usefulness of the rhinology VSE in performing the Draf 3 procedure.

Methods: An outside-in Draf 3 procedure was performed on 4 cadaver heads. Read More

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http://dx.doi.org/10.1002/alr.22333DOI Listing

A longitudinal analysis of urologic chronic pelvic pain syndrome flares in the mapp research network.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Objective: To describe the frequency, intensity, and duration of urologic chronic pelvic pain syndrome symptom exacerbations ("flares"), as well as risk factors for these features, in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Epidemiology and Phenotyping longitudinal study.

Participants And Methods: Current flare status ("urologic or pelvic pain symptoms that are much worse than usual") was ascertained at each bi-weekly assessment. Flare characteristics, including start date, and current intensity of pelvic pain, urgency, and frequency (scales of 0-10), were assessed for participants' first three flares and at three randomly selected times when they did not report a flare. Read More

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http://dx.doi.org/10.1111/bju.14783DOI Listing

Contact allergy to metals and "multiple chemical sensitivity".

Contact Dermatitis 2019 Apr 23. Epub 2019 Apr 23.

Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's Hospital, London, UK.

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http://dx.doi.org/10.1111/cod.13280DOI Listing

[EXPRESS] Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.

Mol Pain 2019 Apr 23:1744806919845750. Epub 2019 Apr 23.

Wake Forest Baptist Medical Center.

Since the failure of specific substance P antagonists to induce analgesia, the role of tachykinins in the development of neuropathic pain states has been discounted. This conclusion was reached without studies on the role of tachykinins in normal patterns of primary afferents response and sensitization or the consequences of their absence on the modulation of primary mechano-nociceptive afferents after injury. Nociceptive afferents from animals lacking tachykinins (Tac1 knockout: KO) showed a disrupted pattern of activation to tonic suprathreshold mechanical stimulation. Read More

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http://dx.doi.org/10.1177/1744806919845750DOI Listing

Cost implications of adverse drug event-related emergency department visits - a multi-center study in South Korea.

Expert Rev Pharmacoecon Outcomes Res 2019 Apr 23. Epub 2019 Apr 23.

a School of Pharmacy , Sungkyunkwan University , Suwon , Korea.

Objectives: Adverse drug reactions (ADRs) increase healthcare resource utilization, including that for emergency department (ED) visits. However, cost analyses of ADRs resulting in ED visits are scarce. Therefore, we aimed to estimate the direct medical costs before and after ADR occurrence and analyzed the cost-driving factors. Read More

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http://dx.doi.org/10.1080/14737167.2019.1608825DOI Listing

Focusing on quality of life in chronic rhinosinusitis patients.

Authors:
Justin H Turner

Int Forum Allergy Rhinol 2019 Apr 23. Epub 2019 Apr 23.

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http://dx.doi.org/10.1002/alr.22346DOI Listing

Postoperative epistaxis and sphenoid sinus ostial stenosis after posterior septal branch injury during sphenoidotomy.

Int Forum Allergy Rhinol 2019 Apr 23. Epub 2019 Apr 23.

Department of Otolaryngology-Head and Neck Surgery, Henry Ford Hospital, Detroit, MI.

Background: Postoperative arterial epistaxis and sphenoid sinus stenosis after sphenoidotomies for endoscopic sinus surgery (ESS) and transsphenoidal approaches (TSAs) are uncommon. One potential source of epistaxis after sphenoidotomy is the sphenopalatine artery's posterior septal branch (PSB). PSB injury, in addition to other factors, could increase the risk of sphenoid stenosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22345
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http://dx.doi.org/10.1002/alr.22345DOI Listing
April 2019
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Visceral sensitivity remains stable over time in patients with irritable bowel syndrome, but with individual fluctuations.

Neurogastroenterol Motil 2019 Apr 22:e13603. Epub 2019 Apr 22.

Department of Internal Medicine & Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

Background: Visceral hypersensitivity in irritable bowel syndrome (IBS), measured with rectal balloon distensions, using a barostat, has been suggested to be a phenomenon that is reduced due to habituation at repeated investigations. We investigated the stability of rectal sensitivity in patients with IBS who had undergone a previous rectal barostat study and assessed variations in symptom pattern and severity in relation to rectal sensory function.

Method: Irritable bowel syndrome patients, who had previously been undergone a rectal barostat study, were included. Read More

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http://dx.doi.org/10.1111/nmo.13603DOI Listing

Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience.

World J Pediatr 2019 Apr 22. Epub 2019 Apr 22.

Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital, Minatojima-Minamimachi 1-6-7, Chuo-ku, Kobe, 650-0047, Japan.

Background: There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in children. The aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care hospital.

Methods: Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12519-019-00259-xDOI Listing

Recorded Penicillin Allergy and Risk of Mortality: a Population-Based Matched Cohort Study.

J Gen Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11606-019-04991-yDOI Listing

Retreatment with carboplatin and paclitaxel for recurrent endometrial cancer: A retrospective study of the Memorial Sloan Kettering Cancer Center experience.

Gynecol Oncol Rep 2019 May 5;28:120-123. Epub 2019 Apr 5.

Memorial Sloan Kettering Cancer Center, Department of Medicine, Gynecologic Medical Oncology Service, 300 East 66 St, New York, NY 10065, USA.

Women with endometrial cancer (EC) frequently receive adjuvant paclitaxel and carboplatin (PC) chemotherapy. There is no standard first line chemotherapy at disease recurrence. Data extrapolated from ovarian cancer has suggested that patients with recurrent EC may benefit from further platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1016/j.gore.2019.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461565PMC

Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept.

Aging Dis 2019 Apr 1;10(2):367-382. Epub 2019 Apr 1.

8Department of Physiology, The University of Texas Health Science Center at San Antonio, TX 78229, USA.

Age-associated chronic inflammation is characterized by unresolved and uncontrolled inflammation with multivariable low-grade, chronic and systemic responses that exacerbate the aging process and age-related chronic diseases. Currently, there are two major hypotheses related to the involvement of chronic inflammation in the aging process: molecular inflammation of aging and inflammaging. However, neither of these hypotheses satisfactorily addresses age-related chronic inflammation, considering the recent advances that have been made in inflammation research. Read More

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http://www.aginganddisease.org/EN/10.14336/AD.2018.0324
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http://dx.doi.org/10.14336/AD.2018.0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457053PMC
April 2019
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Retinal alterations in a pre-clinical model of an autism spectrum disorder.

Mol Autism 2019 15;10:19. Epub 2019 Apr 15.

3Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP 05508-000 Brazil.

Background: Autism spectrum disorders (ASD) affect around 1.5% of people worldwide. Symptoms start around age 2, when children fail to maintain eye contact and to develop speech and other forms of communication. Read More

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http://dx.doi.org/10.1186/s13229-019-0270-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466731PMC

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.

Nat Cell Biol 2019 Apr 22. Epub 2019 Apr 22.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been identified. Here a global analysis of exon usage in AML samples revealed distinct molecular subsets containing alternative spliced isoforms of inflammatory and immune genes. Interleukin-1 receptor-associated kinase 4 (IRAK4) was the dominant alternatively spliced isoform in MDS and AML and is characterized by a longer isoform that retains exon 4, which encodes IRAK4-long (IRAK4-L), a protein that assembles with the myddosome, results in maximal activation of nuclear factor kappa-light-chain-enhancer of B cells (NF-κB) and is essential for leukaemic cell function. Read More

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http://dx.doi.org/10.1038/s41556-019-0314-5DOI Listing

Jasmonate-mediated wound signalling promotes plant regeneration.

Nat Plants 2019 Apr 22. Epub 2019 Apr 22.

National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.

Wounding is the first event triggering regeneration. However, the molecular basis of wound signalling pathways in plant regeneration is largely unclear. We previously established a method to study de novo root regeneration (DNRR) in Arabidopsis thaliana, which provides a platform for analysing wounding. Read More

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http://dx.doi.org/10.1038/s41477-019-0408-xDOI Listing

Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases.

J Immunol 2019 May;202(9):2519-2526

Department of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110;

Inducible bronchus-associated lymphoid tissue (iBALT) is a tertiary lymphoid structure that resembles secondary lymphoid organs. iBALT is induced in the lung in response to Ag exposure. In some cases, such as infection with , the formation of iBALT structure is indicative of an effective protective immune response. Read More

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http://dx.doi.org/10.4049/jimmunol.1801135DOI Listing

[Hypersensitivity pneumonitis in children].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Service de pneumologie, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France; UMR CNRS 6249, Chrono-environnement, université de Franche-Comté, 25000 Besançon, France. Electronic address:

Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.06.010DOI Listing

Clinical Management of Cutaneous Adverse Events in Patients on Chemotherapy: A National Consensus Statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology.

Actas Dermosifiliogr 2019 Apr 19. Epub 2019 Apr 19.

Servicio de Oncología Médica, Hospital Universitario Doce de Octubre, Madrid, España.

Although the arrival of new chemotherapy drugs and combinations has brought progress in terms of cancer patient survival, they entail many adverse effects that can compromise treatment, and hence prognosis, of the disease. Cytostatic agents can cause dermatological toxicity, among other side effects. The most familiar adverse effect of chemotherapy is alopecia. Read More

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http://dx.doi.org/10.1016/j.ad.2019.01.011DOI Listing

Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.

J Invest Dermatol 2019 May 19;139(5):995-996. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Munich, Germany. Electronic address:

Psoriasis is a T helper type 17-mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.026DOI Listing

The Aging Lung and Idiopathic Pulmonary Fibrosis.

Am J Med Sci 2019 May 12;357(5):384-389. Epub 2019 Feb 12.

Division of Pulmonary, Allergy, and Critical Care Medicine and; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Idiopathic pulmonary fibrosis (IPF) is one of many clinical syndromes that are associated with aging, and is increasing in both incidence and prevalence with the rapid rise in aging populations world-wide. There is accumulating data on how the biology of aging may influence the susceptibility to lung fibrosis in the elderly. In this review, we explore some of the known "hallmarks of aging," including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, cellular senescence and mitochondrial dysfunction in the pathobiology of IPF. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.02.008DOI Listing

Epithelial Injury and Dysfunction in the Pathogenesis of Idiopathic PulmonaryFibrosis.

Am J Med Sci 2019 May 22;357(5):374-378. Epub 2019 Jan 22.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicineand; Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee; Department of Veterans Affairs Medical Center, Nashville, Tennessee. Electronic address:

Idiopathic pulmonary fibrosis is a disease of older adults leading to progressive dyspnea and reduced exercise capacity, typically resulting in death within 3-5years of diagnosis. Underlying genetic susceptibility combined with environmental insults is proposed to trigger a chronic wound repair response, leading to activation of the fibrotic cascade. Perturbations in several molecular pathways mediate vulnerability of the alveolar epithelium to injurious agents, including the unfolded protein response, autophagy, mitophagy, and cellular senescence. Read More

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http://dx.doi.org/10.1016/j.amjms.2019.01.010DOI Listing

Humoral Response to the HIV-1 Envelope V2 Region in a Thai Early Acute Infection Cohort.

Cells 2019 Apr 19;8(4). Epub 2019 Apr 19.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Reduced risk of HIV-1 infection correlated with antibody responses to the envelope variable 1 and 2 regions in the RV144 vaccine trial. To understand the relationship between antibody responses, V2 sequence, and structure, plasma samples (n = 16) from an early acute HIV-1 infection cohort from Thailand infected with CRF01_AE strain were analyzed for binding to V2 peptides by surface plasmon resonance. Five participants with a range of V2 binding responses at week 24 post-infection were further analyzed against a set of four overlapping V2 peptides that were designed based on envelope single-genome amplification. Read More

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http://dx.doi.org/10.3390/cells8040365DOI Listing

Immunophenotype of T Cells Expressing Programmed Death-1 and Cytotoxic T Cell Antigen-4 in Early Lung Cancer: Local vs. Systemic Immune Response.

Cancers (Basel) 2019 Apr 21;11(4). Epub 2019 Apr 21.

Department of Internal Medicine, Pulmonary Diseases and Allergy, Medical University of Warsaw, ul. Banacha 1a, 02-097 Warsaw, Poland.

The overexpression of programmed death-1 (PD-1) and cytotoxic T cell antigen 4 (CTLA-4) receptors on T cells are among the major mechanisms of tumor immunoevasion. However, the expression pattern of these receptors on T cell subpopulations of a different activation status and at different sites is poorly characterized. Thus, we analyzed the expression of PD-1 and CTLA-4 on the naïve, activated, memory, and activated memory T cells. Read More

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http://dx.doi.org/10.3390/cancers11040567DOI Listing

Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among and .

Viruses 2019 Apr 20;11(4). Epub 2019 Apr 20.

Disease Intervention and Prevention, Texas Biomedical Research Institute, 8715 W. Military Dr., San Antonio, TX 78227-5302, USA.

We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the periplasm. Periplasmic expression preserves authentic antibody N-termini, intra-domain disulphide bond(s), and capitalizes on efficient haem loading through the porous outer membrane. Using monomeric and dimeric anti-nucleoprotein (NP) sdAb cross-reactive within the genus and cross-reactive within the genus, we show that periplasmic sdAb-APEX2 fusion proteins are easily purified at multi-mg amounts. Read More

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http://dx.doi.org/10.3390/v11040364DOI Listing

A Multicomponent Intervention to Improve Pneumococcal Vaccination Knowledge Among Internal Medicine Residents.

MedEdPORTAL 2016 Jun 10;12:10414. Epub 2016 Jun 10.

Assistant Professor of Pulmonary, Critical Care, Allergy and Immunologic Disease, Wake Forest School of Medicine.

Introduction: The Advisory Committee on Immunization Practices updated its pneumococcal vaccination guidelines in September 2014 and provided an additional recommendation in February 2016. We perceived a knowledge gap related to these guidelines among residents who serve as primary care physicians during postgraduate training. Our research team confirmed the presence of this knowledge gap and designed a curriculum focused on the current guidelines for pneumococcal vaccination. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464476PMC

Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient.

Matters (Zur) 2018 23;2018. Epub 2018 May 23.

Systems and Cell Biology of Neurodegeneration, University of Zurich, James Martin Stem Cell Facility, University of Oxford, Division of Immunology, University Children's Hospital Zurich, Div. of Immunology, University Children's Hospital Zurich, Children's Research Center, Associated Group Institute for Regenerative Medicine, Department of Psychiatry, Sir William Dunn School of Pathology, University of Oxford, Icahn School of Medicine at Mount Sinai, HIV-Specific Immunity Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA, James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, Professor emeritus University Children's Hospital Zürich, Division of Immunology, Professor emeritus Children's Research Center, Div. of Immunology, University Children's Hospital Zurich, Children's Research Center, Associated Group Institute for Regenerative Medicine, University of Zürich, Center for Applied Biotechnology and Molecular Medicine, University of Zürich, Div. of Immunology, University Children's Hospital Zürich, Children's Research Center, Associated Group Institute for Regenerative Medicine, University of Zürich.

A recent gamma-retroviral clinical Chronic Granulomatous Disease (CGD) gene therapy (GT) trial achieved proof-of-concept but was accompanied by activation of oncogenes and transgene silencing. The (UCOE) comprises the sequences of two divergently oriented house-keeping gene promoters and is known to have anti-silencing properties. In a screen we identified two novel UCOE constructs that prevent adjacent promoter methylation in P cells. Read More

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http://dx.doi.org/10.19185/matters.201805000005DOI Listing

Statistical Methods for Standard Membrane-Feeding Assays to Measure Transmission Blocking or Reducing Activity in Malaria.

J Am Stat Assoc 2018 12;113(522):534-545. Epub 2018 Jun 12.

National Institute of Allergy and Infectious Diseases, Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, MD.

Transmission blocking vaccines for malaria are not designed to directly protect vaccinated people from malaria disease, but to reduce the probability of infecting other people by interfering with the growth of the malaria parasite in mosquitoes. Standard membrane-feeding assays compare the growth of parasites in mosquitoes from a test sample (using antibodies from a vaccinated person) compared to a control sample. There is debate about whether to estimate the transmission reducing activity (TRA) which compares the mean number of parasites between test and control samples, or transmission blocking activity (TBA) which compares the proportion of infected mosquitoes. Read More

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http://dx.doi.org/10.1080/01621459.2017.1356313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469714PMC

Pharmaceutical and preclinical evaluation of Advax adjuvant as a dose-sparing strategy for ant venom immunotherapy.

J Pharm Biomed Anal 2019 Apr 9;172:1-8. Epub 2019 Apr 9.

Jack Jumper Allergy Program, Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania, 7001, Australia; School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide, South Australia, 5001, Australia.

A major challenge in broader clinical application of Jack Jumper ant venom immunotherapy (JJA VIT) is the scarcity of ant venom which needs to be manually harvested from wild ants. Adjuvants are commonly used for antigen sparing in other vaccines, and thereby could potentially have major benefits to extend JJA supplies if they were to similarly enhance JJA VIT immunogenicity. The purpose of this study was to evaluate the physicochemical and microbiological stability and murine immunogenicity of low-dose JJA VIT formulated with a novel polysaccharide adjuvant referred to as delta inulin or Advax™. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.017DOI Listing

Impaired learning from punishment of errors in smokers: Differences in dorsolateral prefrontal cortex and sensorimotor cortex blood-oxygen-level dependent responses.

Neuroimage Clin 2019 Apr 8;23:101819. Epub 2019 Apr 8.

School of Psychological Sciences, University of Melbourne, 12th floor Redmond Barry Building, Parkville Campus, Melbourne, VIC 3010, Australia. Electronic address:

Cigarette smokers have shown hypersensitivity to reward and hyposensitivity to punishment, along with impairments in learning from errors. The underlying neural mechanism for this failure to adapt performance following an error, particularly when receiving negative feedback, are unclear. Smokers were hypothesized to have poorer error-learning following monetary punishment, associated with hypoactivation in the insula, dorsal anterior cingulate, and hippocampal cortical regions. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101819DOI Listing

Cost-effective care in eosinophilic esophagitis.

Authors:
Evan S Dellon

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.010DOI Listing

Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Pediatric Pneumology and Allergology unit, Necker-Enfants Malades Hospital, Paris, France; Université Paris Descartes, Paris, France.

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http://dx.doi.org/10.1016/j.anai.2019.04.011DOI Listing

Acute Care Beta-Lactam Allergy Pathways: Approaches and Outcomes.

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Medical Practice Evaluation Center, Mongan Institute, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.009DOI Listing

Chronological order of appearance of immune mediated inflammatory diseases relative to diagnosis of psoriasis.

J Am Acad Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark. Electronic address:

Background: Psoriasis is a common inflammatory skin disease which is associated with several immune-mediated inflammatory diseases (IMIDs), however little is known of the chronology of the disease development.

Objective: To investigate the chronology of IMIDs relative to psoriasis.

Methods: We utilized routinely collected data from Danish nationwide administrative registries to examine the occurrence of IMIDs in patients with psoriasis (n=10,923) and general population controls (n=109,230). Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.033DOI Listing

Matrix metalloproteinase-12 produced by Ly6C macrophages prolongs the survival after myocardial infarction by preventing neutrophil influx.

J Mol Cell Cardiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Background: Various immune cells are involved in different phases of cardiac repair after myocardial infarction (MI). Especially, Ly6C M2-like macrophages (Ly6C macrophages) are vital for cardiac repair after MI. However, the molecular mechanisms how Ly6C macrophages promote wound healing after MI are still largely unknown. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.007DOI Listing