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Allergy 2019 Feb;74(2):418-419

Allergie-Centrum-Charite, Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Allergy 2019 Feb;74(2):209-212

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: Although pollen-related food allergy occurs in all European populations, Lipid Transfer Protein (LTP) allergy is considered to manifests mainly in Mediterranean countries. We aimed to characterise adults presenting with LTP allergy in a Northern European country.

Method: The clinical history and sensitisation patterns of subjects born and residing in the United Kingdom (UK), with a prior diagnosis of LTP allergy and sensitisation to the peach LTP allergen Pru p 3, were compared to UK subjects with pollen food syndrome (PFS). Read More

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Molecular Allergy Research Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.

Background: Commercial allergen extracts for allergy skin prick testing (SPT) are widely used for diagnosing fish allergy. However, there is currently no regulatory requirement for standardisation of protein and allergen content, potentially impacting the diagnostic reliability of SPTs. We therefore sought to analyse commercial fish extracts for the presence and concentration of fish proteins and in vitro IgE reactivity using serum from fish-allergic patients. Read More

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Sachs' Children's Hospital, Stockholm, Sweden.

Background: The presence of allergic sensitization has a major influence on the development and course of common childhood conditions such as asthma and rhinitis. The etiology of allergic sensitization is poorly understood and its underlying biological mechanisms are not well established. Several studies showed that DNA methylation (DNAm) at some CpGs is associated with allergic sensitization. Read More

Allergy 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology, Duke University School of Medicine, Durham, NC, 27710.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Germany.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Cardiorespiratory Research, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedical Sciences and Human Oncology Unit of Internal Medicine "G. Baccelli", University of Bari Medical School - Aldo Moro, Bari, Italy.

Allergy 2019 Feb 11. Epub 2019 Feb 11.

Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto Portugal & Centro Hospitalar São João, Porto, Portugal.

Background: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known. We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren. Read More

Allergy 2019 Feb 10. Epub 2019 Feb 10.

Department of Dermatology, Venereology, and Allergology, University Hospital Würzburg, Germany.

Allergy 2019 Feb 10. Epub 2019 Feb 10.

Department of Dermatology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain Universidad de Las Palmas de Gran Canaria, Spain.

Allergy 2019 Feb 9. Epub 2019 Feb 9.

Allergy Section. Internal Medicine Department.Hospital, Universitari Vall d'Hebron, Barcelona, Spain.

Allergy 2019 Feb 9. Epub 2019 Feb 9.

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Allergy 2019 Feb 9. Epub 2019 Feb 9.

Department of Pulmonary and Allergy, Dr. von Hauner Children's Hospital, LMU, Lindwurmstraße 4, 80337, Munich, Germany.

Background: Associations between childhood asthma phenotypes and genetic, immunological and environmental factors have been previously established. Yet, strategies to integrate high-dimensional risk factors from multiple distinct data sets, and thereby increase the statistical power of analyses, have been hampered by a preponderance of missing data and lack of methods to accommodate them.

Methods: We assembled questionnaire, diagnostic, genotype, microarray, RT-qPCR, flow cytometry and cytokine data (referred to as data modalities) to use as input factors for a classifier that could distinguish healthy children, mild-to-moderate allergic asthmatics and non-allergic asthmatics. Read More

Allergy 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria.

Allergy 2019 Jan;74(1):5-8

Allergy 2019 Jan 29. Epub 2019 Jan 29.

Allergy Centre, Tampere University Hospital, Tampere, Finland.

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Pharmacology& Experimental Therapeutics Unit, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel.

Background: Siglec-7 is an inhibitory receptor (IR) expressed on human blood eosinophils. Whereas activation of other IRs, including Siglec-8 and CD300a, has been shown to downregulate eosinophil function, little is known about the role of Siglec-7 on human eosinophils.

Objective: To examine Siglec-7 expression and function in eosinophils from normal (ND) and eosinophilic (EO) donors. Read More

Allergy 2019 Jan 28. Epub 2019 Jan 28.

Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia.

Background: Despite an increasing number of publications from individual countries and regions, there is still no systematic review of the global epidemiology of anaphylaxis in the general paediatric population.

Methods: We conducted a systematic review, using a protocol registered and published with the international prospective register of systematic reviews (PROSPERO). Results were reported following PRISMA guidelines. Read More

Allergy 2019 Jan 22. Epub 2019 Jan 22.

Airways Disease, National Heart & Lung Institute, Imperial College, London, UK.

Background: Eosinophils play an important role in the pathophysiology of asthma being implicated in airway epithelial damage and airway wall remodeling. We determined the genes associated with airway remodeling and eosinophilic inflammation in patients with asthma.

Methods: We analyzed the transcriptomic data from bronchial biopsies of 81 patients with moderate-to-severe asthma of the U-BIOPRED cohort. Read More

Allergy 2019 Jan 22. Epub 2019 Jan 22.

Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan.

Background: Eosinophils are multifunctional granulocytes capable of releasing various cytokines, chemokines, and lipid mediators. We previously reported dysregulated fatty acid metabolism in peripheral blood-derived eosinophils from patients with severe asthma. However, functional characteristics of eosinophils present in allergic inflammatory tissues remains largely uncharacterized. Read More

Allergy 2019 Jan 22. Epub 2019 Jan 22.

Allergy Unit, IBIMA-Hospital Regional Universitario de Málaga-ARADyAL, UMA, Málaga, Spain.

Background: The nasal allergen challenge (NAC) is a useful tool for the diagnosis of allergic rhinitis (AR) and local allergic rhinitis (LAR) and might serve to design and monitor allergen immunotherapy. Nevertheless, data about its safety and reproducibility are scarce.

Objective: To investigate the safety and reproducibility of NAC in pediatric and adult rhinitis patients with/without asthmatic symptoms, and in healthy controls. Read More

Allergy 2019 Jan 22. Epub 2019 Jan 22.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Faculty of Medicine, Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.

Allergy 2019 Jan 22. Epub 2019 Jan 22.

ARADyAL Network RD16/0006/0001, Carlos III Health Institute, Madrid, Spain.

Background: The role of arachidonic acid metabolites in NSAID-induced hypersensitivity has been studied in depth for NSAID-exacerbated respiratory disease (NERD) and NSAID-exacerbated cutaneous disease (NECD). However, no information is available for NSAID-induced urticarial/angioedema (NIUA), despite it being the most frequent clinical entity induced by NSAID hypersensitivity. We evaluated changes in leukotriene and prostaglandin metabolites for NIUA patients, using patients with NECD and single-NSAID-induced urticaria/angioedema or anaphylaxis (SNIUAA) for comparison. Read More

Allergy 2019 Jan 17. Epub 2019 Jan 17.

Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Allergy 2019 Jan 15. Epub 2019 Jan 15.

Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.

Adverse reactions to insects occur in both human and veterinary patients. Systematic comparison may lead to improved recommendations for prevention and treatment in all species. In this position paper, we summarize the current knowledge on insect allergy induced via stings, bites, inhalation or ingestion, and compare reactions in companion animals to those in people. Read More

Allergy 2019 Jan 15. Epub 2019 Jan 15.

Department of Otorhinolaryngology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

Background: The market of mobile health (mHealth) technology is rapidly evolving, making new mobile technologies potentially available for health care systems. Patient empowerment through self-monitoring of symptoms, shared decision making with the physician and easily accessible education are important features extending the reach of mHealth technology beyond traditional care.

Methods: Two digital distribution platforms (Apple App Store and Google Play Store) were searched for currently available mobile applications (apps) for patients with chronic respiratory diseases (CRDs). Read More

Allergy 2019 Jan 14. Epub 2019 Jan 14.

Allergy Unit, Presidio Columbus, Rome, Italy.

An accurate diagnosis of β-lactam (BL) allergy can reduce patient morbidity and mortality. Our aim was to investigate the availability of BL reagents, their use and test procedures in different parts of Europe, as well as any differences in the diagnostic workups for evaluating subjects with BL hypersensitivity. A survey was emailed to all members of the EAACI Drug Allergy Interest Group (DAIG) between February and April 2016, and the questionnaire was meant to study the management of suspected BL hypersensitivity. Read More

Allergy 2019 Jan 12. Epub 2019 Jan 12.

Allergy Vigilance Network®, Vandoeuvre les Nancy, France.

Allergy 2019 Jan 12. Epub 2019 Jan 12.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Allergy 2019 Jan 12. Epub 2019 Jan 12.

Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross-talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Read More

Allergy 2019 Jan 12. Epub 2019 Jan 12.

Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

Peanut is one of the most common food triggers of fatal anaphylaxis worldwide although peanut allergy affects only 1%-2% of the general population. Peanuts are the source of highly potent allergenic proteins. It is emerging that the allergenicity of certain proteins is linked to their biological function. Read More

Allergy 2019 Jan 11. Epub 2019 Jan 11.

Department of Chest Diseases, Division of Allergy and Immunology, Ankara University School of Medicine, Ankara, Turkey.

Allergy 2018 Dec 28. Epub 2018 Dec 28.

Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, the Netherlands.

Allergy 2018 Dec 28. Epub 2018 Dec 28.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Allergy 2018 Dec 28. Epub 2018 Dec 28.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Allergy 2018 Dec 28. Epub 2018 Dec 28.

Department of Medicine Hamilton, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton and McMaster University, ON, Canada.

Allergy 2018 Dec;73(12):2269-2270

Allergy 2018 Dec;73(12):2412

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Division of Immunology & Allergy, School of Medicine, Ankara University, Ankara, Turkey.

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany.

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Murdoch Childrens Research Institute, Parkville, VIC, Australia.

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Background: Histamine is an important immunomodulator influencing both the innate and adaptive immune system. Certain host cells express the histidine decarboxylase enzyme (HDC), which is responsible for catalysing the decarboxylation of histidine to histamine. We and others have shown that bacterial strains can also express HDC and secrete histamine; however, the influence of bacterial-derived histamine on the host immune responses distant to the gut is unclear. Read More

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Environmental Research Center, Duke Kunshan University, Kunshan, China.

Background: Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk factor for eczema, but the association is not clear.

Methods: We used the cross-sectional data from U. Read More

Allergy 2018 Dec 27. Epub 2018 Dec 27.

Department of Pulmonology and Addictology, Arnaud de Villeneuve Hospital, Montpellier University, Montpellier, and Sorbonne Universités, UPMC Paris 06, UMR-S 1136 INSERM, IPLESP, Equipe EPAR, 75013, Paris, France.

Background: Moderate-to-severe allergic rhinitis (AR) may increase the risk of developing or worsening asthma, whereas treatment of AR with subcutaneously or sublingual allergen immunotherapy (SLIT) may slow this progression.

Methods: In a retrospective real-world analysis, prescription fulfilment data were gathered from French retail pharmacies between March 1 , 2012, and December 31 , 2016. Using linear regression analyses, patients having received at least two prescriptions of grass pollen SLIT tablets over at least two successive years were compared with control patients having received symptomatic medications only. Read More

Allergy 2018 Dec 19. Epub 2018 Dec 19.

College of Pharmacy, Yeungnam University, Gyeongsan, Korea.

Background: Nuclear receptor subfamily 4 group A member 1 (NR4A1), an orphan nuclear receptor, has been implicated in several biological events such as metabolism, apoptosis, and inflammation. Recent studies indicate a potential role for NR4A1 in mast cells, yet its role in allergic responses remains largely unknown.

Objectives: The aim of this study was to clarify the role of NR4A1 in mast cell activation and anaphylaxis. Read More

Allergy 2018 Dec 18. Epub 2018 Dec 18.

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. Read More

Allergy 2018 Dec 17. Epub 2018 Dec 17.

Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.