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    11746 results match your criteria Allergy[Journal]

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    Neonatal BCG-vaccination and atopic dermatitis before 13 months of age. A randomised clinical trial.
    Allergy 2017 Sep 20. Epub 2017 Sep 20.
    Paediatric Department, Kolding Hospital.
    Studies have suggested that Bacillus Calmette-Guérin (BCG) vaccination may reduce the risk of allergic diseases, including atopic dermatitis. The Danish Calmette Study was conducted 2012-2015. Within 7 days of birth new-borns were randomised 1:1 to BCG or no BCG. Read More

    AllergoOncology: Opposite Outcomes of Immune Tolerance in Allergy and Cancer.
    Allergy 2017 Sep 16. Epub 2017 Sep 16.
    St. John's Institute of Dermatology; Division of Genetics & Molecular Medicine; Faculty of Life Sciences and Medicine; King's College London, Guy's Hospital, London, UK.
    While desired for the cure of allergy, regulatory immune cell subsets and non-classical Th2-biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours from immunological detection and clearance. A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune cells and mediators. Read More

    Mucocutaneous Inflammation in the Ikaros Family Zinc Finger 1 (IKZF1) - keratin 5 specifc transgenic mice.
    Allergy 2017 Sep 15. Epub 2017 Sep 15.
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. Read More

    The ARIA score of allergic rhinitis using mobile technology correlates with quality-of-life: The MASK study.
    Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Peercode DV, Gerdermalsen, The Netherlands.
    Mobile technology has been used to appraise allergic rhinitis control but more data are needed. In order to better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1,288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2). Read More

    Validation of patient-reported global severity of atopic dermatitis in adults.
    Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.
    Background: Atopic dermatitis (AD) is associated with a heterogeneous presentation and clinical course. There is a lack of simple and validated severity assessments that are feasible for clinical practice and epidemiological research.

    Objectives: We sought to validate patient-reported global AD severity in adults. Read More

    Mast cells and sphingosine-1-phosphate underlie prelesional remodeling in a mouse model of eczema.
    Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
    Atopic dermatitis (AD) is a chronic skin inflammation that affects children and adults worldwide, but its pathogenesis remains ill-understood. We show that a single application of OVA to mouse skin initiates remodeling and cellular infiltration of the hypodermis measured by a newly developed computer-aided method. Importantly, we demonstrate that skin mast cell (MC) activation and local sphingosine-1-phosphate (S1P) are significantly augmented after OVA treatment in mice. Read More

    Current practice of allergy diagnosis and the potential impact of regulation in Europe.
    Allergy 2017 Sep 14. Epub 2017 Sep 14.
    Department of Respiratory Diseases and Allergy, Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark.
    In the European Union (EU), the regulatory framework regarding diagnostic allergen extracts is currently in the process of being implemented at the national level. Due to these regulations, the initial and periodic renewal expenses for the registration of diagnostic allergen extracts may render extract production unprofitable. Consequently, many extracts may be at risk of removal from the market. Read More

    Arerugi 2017 ;66(8):1011-1015
    Department of Allergy, Kanagawa Children's Medical Center.
    A 12-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exercise after meals. Food-dependent exercise-induced anaphylaxis (FDEIAn) was suspected. However, sequential tests of typical foods, including egg, milk, soy, and wheat, in combination with exercise, were all negative. Read More

    Drug Repurposing to treat Asthma and Allergic Disorders: Progress and Prospects.
    Allergy 2017 Sep 7. Epub 2017 Sep 7.
    Division of Allergy & Immunology, Department of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322.
    Allergy and atopic asthma have continued to become more prevalent in modern society despite the advent of new treatments, representing a major global health problem. Common medications such as antihistamines and steroids may have undesirable long-term side effects and lack efficacy in some resistant patients. Biologic medications are increasingly given to treat resistant patients, but they can represent high costs, complex dosing and management, and are not widely available around the world. Read More

    Targeting histone-acetyltransferase Tip60 inhibits intestinal allergy.
    Allergy 2017 Sep 4. Epub 2017 Sep 4.
    The Affiliated, ENT Hospital and the Research Center of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518060, China.
    Background: The over production of IgE plays a critical role in the pathogenesis of allergy; the mechanism is unclear. Histone acetyltransferase (HAT) activities are required in gene transcription of a large number of molecules in the immune system of the body.

    Objectives: This study tests a hypothesis that HAT Tat-interactive protein 60 (Tip60) plays an important role in the initiation of IgE-mediated allergy. Read More

    Association of Breast Milk Fatty Acids and Allergic Disease Outcomes - a Systematic Review.
    Allergy 2017 Sep 4. Epub 2017 Sep 4.
    Allergy and Lung Health Unit Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne, Melbourne, Australia.
    Introduction: Dietary poly unsaturated fatty acids (PUFA) have immune regulatory properties. Breast milk is rich in PUFA, and it has been hypothesised that these PUFAs may be important in the aetiology of allergic diseases. Despite a growing body of evidence, the associations between breast milk PUFA and allergic disease have not previously been systematically reviewed. Read More

    Hen's egg allergen in house and bed dust is significantly increased after hen's egg consumption - a pilot study.
    Allergy 2017 Sep 2. Epub 2017 Sep 2.
    Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin, Berlin, Germany.
    Environmental exposure to food allergens may be a risk factor for cutaneous sensitization. Previous studies could detect peanut allergen in house dust. In this pilot study, we wanted to investigate whether hen's egg allergen is detectable in house dust collected from different household areas and whether levels are increased after intentional hen's egg consumption. Read More

    Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma.
    Allergy 2017 Aug 31. Epub 2017 Aug 31.
    Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center, Baylor College of Medicine, Houston, Texas.
    Background: Recent efficacy studies of asthma biologics have included highly enriched patient populations. Using a similar approach, we examined factors that predict response to omalizumab to facilitate selection of patients most likely to derive the greatest clinical benefit from therapy.

    Methods: Data from two phase III clinical trials of omalizumab in patients with allergic asthma were examined. Read More

    Allergic FcεRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF.
    Allergy 2017 Aug 31. Epub 2017 Aug 31.
    Department of Dermatology and Allergy, Allergy Center Charité, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    While allergic mast cell (MC) degranulation occurs by FcεRI aggregation and varies in strength among subjects, the analogous pseudo-allergic route was recently uncovered to proceed via MRGPRX2. Here, we examine interindividual variability in skin MC responses to FcεRI triggering vs those evoked by MRGPRX2. While population-based variability is comparable between the routes, FcεRI- and MRGPRX2-stimulated pathways are completely independent from each other, and responsiveness to one has therefore no predictive value for the other. Read More

    5-/12-Lipoxygenase-linked cascade contributes to the IL-33-induced synthesis of IL-13 in mast cells, thus promoting asthma development.
    Allergy 2017 Aug 30. Epub 2017 Aug 30.
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea.
    Background: As asthma progresses, the levels of IL-33 in serum are markedly increased and contribute to asthmatic development and exacerbation. Mast cells, one of the principal effector cells in the pathogenesis of asthma, express high levels of the IL-33 receptor ST2 and have been shown to be activated by IL-33. Thus, IL-33 stimulates mast cells to produce Th2-type cytokines such as IL-13, thus contributing to asthmatic development. Read More

    Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis.
    Allergy 2017 Aug 30. Epub 2017 Aug 30.
    Department of Immunology, Chiba University Graduate School of Medicine, Chiba, Japan.
    Background: Allergic rhinitis (AR) consists of three developmental stages that are based on the presence/absence of antigen-specific IgE and symptoms. The pathogenic Th2 (Tpath2) cells constitute a population of Th2 cells with additional potentially pathogenic characteristics. We examined the relationship between Tpath2 cells and the stages of allergic rhinitis by focusing on ST2, which is an IL-33 receptor. Read More

    Altered miR-193a-5p expression in children with cow's milk allergy.
    Allergy 2017 Aug 30. Epub 2017 Aug 30.
    CEINGE-Biotecnologie Avanzate Naples, Italy.
    Background: Cow's milk allergy (CMA) is one of the most common food allergies in children. Epigenetic mechanisms have been suggested to play a role in CMA pathogenesis. We shown that DNA methylation of Th1/Th2 cytokine genes and FoxP3 affects CMA disease course. Read More

    Simultaneous induction of HSP70 expression, and degranulation, in IgE/Ag-stimulated or extracellular HSP70-stimulated mast cells (129/200).
    Allergy 2017 Aug 30. Epub 2017 Aug 30.
    YU-ECI Research Center for Medical Science, Yeungnam University, 280 Daehak-ro, Gyeongsan, Gyeongbuk, 712-749, Republic of Korea.
    Background: In mast cells, induction of HSP70 expression during antigen stimulation has not been reported.

    Methods: Mouse bone marrow derived mast cells (BMMC) were stimulated with IgE/Ag or HSP70. Induction of HSP70 expression, and signaling protein phosphorylation, were evaluated by immunoblotting. Read More

    12-OH-17,18-epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs.
    Allergy 2017 Aug 30. Epub 2017 Aug 30.
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
    Background: Asthma is characterized by airway inflammation and obstruction with eosinophil infiltration into the airway. Arachidonic acid, an omega-6 fatty acid, is metabolized into cysteinyl leukotriene with pro-inflammatory properties for allergic inflammation, whereas the omega-3 fatty acid eicosapentaenoic acid (EPA) and its downstream metabolites are known to have anti-inflammatory effects. In this study, we investigated the mechanism underlying the counter-regulatory roles of EPA in inflamed lungs. Read More

    Challenges in the implementation of the EAACI AIT guidelines: A situational analysis of current provision of allergen immunotherapy.
    Allergy 2017 Aug 29. Epub 2017 Aug 29.
    The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health - University of Padua, Padua, Italy.
    Purpose: The European Academy of Allergy and Clinical Immunology (EAACI) has produced Guidelines on Allergen Immunotherapy (AIT). We sought to gauge the preparedness of primary care to participate in the delivery of AIT in Europe.

    Methods: We undertook a mixed-methods, situational analysis. Read More

    Local allergic rhinitis is an independent rhinitis phenotype: The results of a 10-year follow-up study.
    Allergy 2017 Aug 22. Epub 2017 Aug 22.
    Allergy Unit, IBIMA-Regional University Hospital of Málaga, UMA, Malaga, Spain.
    Background: The knowledge about the natural history of local allergic rhinitis (LAR) is limited. One unmet question is to demonstrate whether LAR should be considered the first step in the development of allergic rhinitis (AR) or an independent phenotype. The aim of this study was to prospectively evaluate the natural history of a population with LAR, the potential conversion to AR with systemic atopy and the development of asthma during 10 years. Read More

    Arerugi 2017 ;66(7):945-952
    Department of Allergy, Tokyo Metropolitan Children's Medical Center.
    Background: Inhaled anticholinergics such as ipratropium bromide (IB), when administered with β2-agonists, are effective in reducing hospital admissions of children presenting to the emergency department with moderate to severe asthma. However, treatment of acute asthma with IB is still uncommon in Japan. The aim of this study was to investigate the effectiveness and safety of IB for the treatment of pediatric acute asthma. Read More

    Comparison and interpretability of the available urticaria activity scores.
    Allergy 2017 Aug 16. Epub 2017 Aug 16.
    Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD , are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. Read More

    Hereditary angioedema with a mutation in the plasminogen gene.
    Allergy 2017 Aug 10. Epub 2017 Aug 10.
    Department of Medical Psychology and Medical Sociology, Johannes Gutenberg University, Mainz, Germany.
    Background: Hereditary angioedema (HAE) with normal C1-INH (HAEnCI) may be linked to specific mutations in the coagulation factor 12 (FXII) gene (HAE-FXII) or functional mutations in other genes that are still unknown. We sought to identify and characterize a hitherto unknown type of HAE with normal C1-INH and without mutation in the F12 gene.

    Methods: The study comprised analysis of whole-exome sequencing, Sanger sequencing, and clinical data of patients. Read More

    Evolution of the IgE and IgG repertoire to a comprehensive array of allergen molecules in the first decade of life.
    Allergy 2017 Aug 8. Epub 2017 Aug 8.
    Department of Pediatrics, Pneumology& Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: In early childhood, the allergen-specific IgG repertoire is mainly directed to animal and vegetable food molecules and infrequently to airborne molecules. It is unknown whether this early pattern is maintained throughout childhood.

    Objective: To investigate the evolution of IgG and IgE responses to a broad panel of allergenic molecules from birth to age 10yrs. Read More

    Allergens displayed on virus-like particles are highly immunogenic but fail to activate human mast cells.
    Allergy 2017 Aug 8. Epub 2017 Aug 8.
    Department of Rheumatology, Immunology and Allergology, University Hospital, University of Bern, Bern, Switzerland.
    Background: The goal of allergen-specific immunotherapy is the induction of protective immune responses in the absence of anaphylactic reactions. We have previously shown that Fel d 1, the major cat allergen, displayed in a repetitive fashion on virus-like particles (VLPs) may fulfill these criteria. Specifically, Fel d 1 on VLPs induced strongly increased protective IgG responses compared to free allergen in mice while anaphylactic reactions were essentially abolished. Read More

    Assessment of eosinophilic airway inflammation as a contribution to the diagnosis of occupational asthma.
    Allergy 2017 Aug 3. Epub 2017 Aug 3.
    Department of Chest Medicine, Centre Hospitalier Universitaire UCL Namur, Université catholique de Louvain, Yvoir, Belgium.
    Background: Ascertaining the presence of asthma through the assessment of nonspecific bronchial hyperresponsiveness (NSBH) is a key step in the diagnosis of occupational asthma (OA). We aimed at investigating whether indices of airway inflammation including fractional exhaled nitric oxide (FeNO) and sputum eosinophils would be useful adjuncts to the measurement of NSBH in diagnosing OA defined as a positive specific inhalation challenge (SIC).

    Methods: The study included 240 consecutive subjects with a suspicion of OA who completed a SIC, of whom 133 showed a positive response. Read More

    Challenges in the implementation of EAACI guidelines on allergen immunotherapy: A global perspective on the regulation of allergen products.
    Allergy 2017 Aug 3. Epub 2017 Aug 3.
    Paul-Ehrlich-Institut, Langen, Germany.
    Regulatory approaches for allergen immunotherapy (AIT) products and the availability of high-quality AIT products are inherently linked to each other. While allergen products are available in many countries across the globe, their regulation is very heterogeneous. First, we describe the regulatory systems applicable for AIT products in the European Union (EU) and in the United States (US). Read More

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