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    11896 results match your criteria Allergy[Journal]

    1 OF 238

    Higher mortality of adults with asthma: a 15 year follow-up of apopulation-based cohort.
    Allergy 2018 Feb 20. Epub 2018 Feb 20.
    Tampere University Hospital(Teiskontie 35), PO BOX 2000, 33521, Tampere, Finland.
    Background: Higher all-cause mortality in asthmatics has been shown previously. Polysensitization is associated with higher morbidity among asthmatic children, and allergic rhinitis and/or allergic conjunctivitis (AR/AC) is associated with higher morbidity in adult asthmatics. Little is known about the effect of AR/AC and other factors on mortality among adult asthmatics. Read More

    Angioedema in Chronic Spontaneous Urticaria Is Underdiagnosed and Has a Substantial Impact: Analyses From ASSURE-CSU.
    Allergy 2018 Feb 20. Epub 2018 Feb 20.
    Novartis Pharma AG, Basel, Switzerland.
    Background: ASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post-hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.

    Methods: This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Read More

    Arerugi 2018 ;67(1):67-71
    hermo Fisher Diagnostics.
    Background: Japanese cypress pollen is a major causative allergen of seasonal allergic rhinitis in Japan. Although ImmunoCAP-specific immunoglobulin E (IgE) reagent Japanese cypress pollen has been widely used as a diagnostic aid, its sensitivity requires enhancement. This study evaluated an improved version of this reagent. Read More

    Arerugi 2018 ;67(1):62-66
    Medical Center for Allergic and Immune Diseases, Yokohama City Minato Red Cross Hospital.
    A 47-year old man presented to our hospital with a 6-month history of malaise, cough and dyspnea on exertion. Laboratory testing revealed the severe hyponatremia. A chest X-ray showed bilateral diffuse micronodules. Read More

    Arerugi 2018 ;67(1):53-61
    National Hospital Organization Mie Hospital.
    Background: The use of asthma control guidelines and anti-inflammatory drugs have significantly decreased the number of severe asthma cases including death from asthma. However, there are few prospective cohort studies among pediatric asthma patients in Japan describing the course of asthma symptoms with the treatment taken into consideration.

    Method: We recruited a total of 851 children diagnosed with asthma through 90 hospitals and clinics in 2004 to 2006. Read More

    Arerugi 2018 ;67(1):46-52
    Department of Respiratory Medicine, Takatsuki Red Cross Hospital.
    Background: Cough is the most frequent presenting complaint in clinics, and is classified into the following three groups: acute, subacute and chronic. The major causes of acute cough are infectious diseases, however, few observations on acute cough have been reported.

    Methods: We retrospectively assessed the causes of acute cough among patients who had visited the respiratory clinic of our hospital because of acute cough from September 2014 to August 2015. Read More

    Arerugi 2018 ;67(1):37-45
    Department of Allergy Aichi Children's Health and Medical Center.
    Background: This study aimed to evaluate the clinical accuracy of specific IgE (sIgE) to Ara h 2 in the diagnosis of peanut allergy (PA). We also investigated the prevalence of complications with other nut allergies in PA patients.

    Methods: The Ara h 2-sIgE titer was examined in patients with positive results for sIgE to peanut from April 2014 to March 2015. Read More

    Association of stat6 gene variants with food allergy diagnosed by double-blind placebo-controlled food challenges.
    Allergy 2018 Feb 19. Epub 2018 Feb 19.
    University of Groningen, University Medical Center Groningen, Department of Paediatric Pulmonology and Paediatric Allergy, GRIAC Research Institute , Groningen,, the Netherlands.
    This study describes the role of two STAT6 gene variants in food allergy using data of patients and their parents who underwent double-blind placebo-controlled food challenges (DBPCFCs). After quality control, 369 trios were analyzed including 262 children (71.0%) with food allergy. Read More

    Clinical trials in allergen immunotherapy: current concepts and future needs.
    Allergy 2018 Feb 15. Epub 2018 Feb 15.
    Allergy and Asthma Center Westend, Berlin, Germany.
    Allergen immunotherapy (AIT) is a safe, effective treatment for allergic rhinoconjunctivitis and allergic asthma. However, AIT's clinical effect is still contested - primarily due to heterogeneity in clinical trial designs, study populations, therapeutic formulations and efficacy criteria. After discussing current concepts and unmet needs, an international panel of experts made several recommendations: (i) explore and validate definitions for [clinical] responders in AIT-trials; (ii) use of well-documented, standardized provocation tests prior to inclusion of subjects with relevant diseases in AIT trials; (iii) monitoring neo-sensitizations and occurrence of new allergy in extended AIT trials, and exclusion of polyallergic participants; (iv) validation of allergen exposure chambers with regard to natural exposure; (v) in studies of seasonal allergies, focus on peak exposure but also consider organising two parallel, geographically distinct but otherwise identical trials; (vi) discuss adaptive trial designs with the regulatory authorities; (vii) use e-health and m-health technologies to capture more information on individual exposure to allergens; (viii) initiate research on potential psychological, biochemical, immune, neural and even genomic markers of the placebo response; (ix) identify trial designs and primary endpoints that will give children with allergies easier, faster access to AIT formulations; and (x) promote and apply standardized methods for reporting systemic and local adverse events. Read More

    Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3Treg cells.
    Allergy 2018 Feb 8. Epub 2018 Feb 8.
    Molecular Microbiology and Immunology, Brown University, RI, USA.
    Background: Chitotriosidase (Chitnase 1, Chit1), a major true chitinase in humans, is induced in childhood asthma and has been implicated in the pathogenesis of a variety of inflammatory and tissue remodeling responses. We hypothesized that Chit1 plays a significant role in the pathogenesis of allergic asthma. To identify the role of Chit1, the mechanisms that underlie these contributions and the relevance of these murine findings to childhood asthma. Read More

    Role of IL-13Rα2 in modulating IL-13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa.
    Allergy 2018 Feb 6. Epub 2018 Feb 6.
    Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
    Background: The IL-13 receptor α2 (IL-13Rα2) is a receptor for IL-13 which has conflicting roles in mediating IL-13 responses in the lower airway; with little known about its impact on upper airway diseases. We sought to investigate the expression of IL-13 receptors, IL-13Rα1 and IL-13Rα2, in chronically inflamed nasal epithelium, and explore IL-13 induced signaling pathways in an in vitro model of human nasal epithelial cells (hNECs).

    Methods: The protein and mRNA expression levels of IL-13 and its receptors in nasal biopsies of patients with nasal polyps (NP) and healthy controls were evaluated. Read More

    Development and Validation of the Mastocytosis Activity Score: MAS.
    Allergy 2018 Feb 6. Epub 2018 Feb 6.
    Interdisciplinary Mastocytosis Center Charité, Department of Dermatology and Allergy Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Background: Mastocytosis is a heterogeneous disease characterized by a clonal expansion of mast cells in various organs. The vast majority of patients suffer from signs and symptoms caused by mediator release from mast cells. Although the disease burden is high, there is currently no specific and validated instrument to measure and monitor signs and symptoms in patients with mastocytosis. Read More

    IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis.
    Allergy 2018 Jan 30. Epub 2018 Jan 30.
    Department of Immunology, University Medical Center, Rotterdam, The Netherlands.
    Despite the critical role of soluble IgE in the pathology of IgE-mediated allergic disease, little is known about abnormalities in the memory B-cells and plasma cells that produce IgE in allergic patients. We here applied a flowcytometric approach to cross-sectionally study blood IgE+ memory B-cells and plasmablasts in 149 children with atopic dermatitis, food allergy and/or asthma, and correlated these to helper-T(h)2 cells and eosinophils. Children with allergic disease had increased numbers of IgE+CD27- and IgE+CD27+ memory B-cells and IgE+ plasmablasts, as well as increased numbers of eosinophils and Th2 cells. Read More

    Asthma and IgE associated polymorphisms affect expression of T17 genes.
    Allergy 2018 Jan 30. Epub 2018 Jan 30.
    Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
    T17 cells contribute to the pathogenesis of chronic inflammatory diseases such as asthma and T17 pathway tagging SNPs were associated with asthma and total serum IgE levels in childhood. In this study genotype-specific effects of these SNPs on the expression of T17 related molecules were analyzed in peripheral blood mononuclear cells (PBMCs) before and after allergen stimulation in 61 individuals. After correction for multiple testing, protein or mRNA expression levels of several molecules, including IL-17A, IL17-F, IL-23 and IL-23 receptor, were significantly correlated with asthma-associated SNPs (located in IL17F, IL22, IL23R and IL23A) and IgE-associated polymorphisms (located in IL17A and three SNPs in IL12B). Read More

    Prediction of the severity of allergic reactions to foods.
    Allergy 2018 Jan 30. Epub 2018 Jan 30.
    University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergy, Groningen, The Netherlands.
    Background: There is currently considerable uncertainty regarding what the predictors of the severity of diagnostic or accidental food allergic reactions are, and to what extent the severity of such reactions can be predicted.

    Objective: To identify predictors for the severity of diagnostic and accidental food allergic reactions and to quantify their impact.

    Methods: The study population consisted of children with a double-blind, placebo-controlled food challenge (DBPCFC) confirmed food allergy to milk, egg, peanut, cashew nut and/or hazelnut. Read More

    EAACI Guidelines on Allergen Immunotherapy: Executive Statement.
    Allergy 2018 Jan 30. Epub 2018 Jan 30.
    Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.
    The allergist's community has recently celebrated 100 year of Allergen Immunotherapy (AIT). Unfortunately the implemention of this treatment is still impaired by some challenges. With the diversity of definitions, methodology and different allergen products used, research studies have produced conflicting outcomes. Read More

    Position Paper on the Standardization of Nasal Allergen Challenges.
    Allergy 2018 Jan 27. Epub 2018 Jan 27.
    Department for Medical Statistics Informatics and Epidemiology, IMSIE Medical Faculty of the University of Cologne, Lindenburger Allee 42, 50931, Köln Cologne, Germany.
    Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. Read More

    A novel glycocluster molecule prevents timothy-induced allergic airway inflammation in mice.
    Allergy 2018 Jan 26. Epub 2018 Jan 26.
    Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku University Hospital, Turku, Finland.
    Background: Allergen-specific immunotherapy (SIT) effectively alleviates type I allergic diseases characterized by T helper (Th)2-type immunity. Our recent studies have shown that a synthetic trivalent glycocluster, triacedimannose (TADM), suppresses the Th2-type allergic inflammation. The aim of this study was to compare TADM with two well-known adjuvants, unmethylated cytosine-phosphate-guanine oligodeoxynucleotide (CpG) and monophosphoryl lipid A (MPLA) in a grass allergen-induced chronic allergic inflammation model in mice. Read More

    Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy.
    Allergy 2018 Jan 22. Epub 2018 Jan 22.
    Inflammation, Chimiokines et Immunopathologie, INSERM, Univ.Paris-Sud, Université Paris-Saclay, 92290, Châtenay-Malabry, France.
    Background: There is in vitro evidence that T-cells from allergic patients react to benzylpenicillin-human serum albumin (BP-HSA) bioconjugates. Our group has recently shown the existence of naïve CD4T lymphocytes recognizing BP-HSA in healthy donors. However, BP-haptenated peptides from HSA participating in the immunization of allergic patients have never been identified. Read More

    Molecular allergen profiling in horses by microarray reveals Fag e 2 from buckwheat as a frequent sensitizer.
    Allergy 2018 Jan 19. Epub 2018 Jan 19.
    The interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.
    Background: Companion animals are also affected by IgE-mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles.

    Methods: Custom-designed allergen microarray was produced on the basis of the IimmunoCAP ISAC technology containing 131 allergens. Read More

    Sputum cytology during late-phase responses to inhalation challenge with different allergens.
    Allergy 2018 Jan 16. Epub 2018 Jan 16.
    QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
    Background: In mouse models of allergic asthma, exposure to different allergens can trigger distinct inflammatory subtypes in the airways. We investigated whether this observation extends to humans.

    Methods: We compared the frequency of sputum inflammatory subtypes between mild allergic asthma subjects (n = 129) exposed to different allergens in inhalation challenge tests. Read More

    Executive summary: Methods and evidence report for the evidence - and consensus- based (S3) Guideline for the definition, classification, diagnosis, and management of urticaria - revision and update 2017.
    Allergy 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health.
    For the revision and update of the EAACI/GA²LEN/EDF/WAO guideline on urticaria we defined and followed a structured process as recommended by national and international guideline development manuals (1) and took the Appraisal of Guidelines Research and Evaluation (AGREE II) Instrument (2) into account. The full methods report can be found in the online appendix [please add link]. This article is protected by copyright. Read More

    Treatment of allergic rhinitis using mobile technology with real world data: The MASK observational pilot study.
    Allergy 2018 Jan 15. Epub 2018 Jan 15.
    Celal Bayar University Department of Pulmonology, Manisa, Turkey and GARD Executive Committee.
    Background: Large observational implementation studies are needed to triangulate the findings from randomized control trials (RCTs) as they reflect "real world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real life treatment of allergic rhinitis using mobile technology.

    Methods: A mobile phone app (Allergy Diary, freely available Google Play and Apple App stores) collects the data of daily visual analogue scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries. Read More

    The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. The 2017 Revision and Update.
    Allergy 2018 Jan 15. Epub 2018 Jan 15.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charité.
    This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. Read More

    Outdoor pollen is a trigger of child and adolescent asthma ED presentations: a systematic review and meta-analysis.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    Background: In the context of increased asthma exacerbations associated with climatic changes such as thunderstorm asthma, interest in establishing the link between pollen exposure and asthma hospital admissions has intensified. Here, we systematically reviewed and performed a meta-analysis of studies on pollen and ED attendance.

    Methods: A search for studies with appropriate search strategy in Medline, Embase, Web of Science and CINAHL was conducted. Read More

    How does dose impact on the severity of food-induced allergic reactions, and can this improve risk assessment for allergenic foods?: Report from an ILSI Europe Food Allergy Task Force Expert Group and Workshop.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Unilever, Bedford, UK.
    Quantitative risk assessment (QRA) for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depends on multiple factors, related to the allergen, the host and any treatments, which might be administered. Some of these factors are plausibly still unknown. Read More

    Prevalence, severity, and risk factors for acute exacerbations of nasal and sinus symptoms by chronic rhinosinusitis status.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Department of Environmental Health and Engineering, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MA, USA.
    Background: Nasal and sinus symptoms (NSS) are common to many health conditions, including chronic rhinosinusitis (CRS). Few studies have investigated the occurrence and severity of, and risk factors for, acute exacerbations of NSS (AENSS) by CRS status (current, past, or never met European Position Paper on Rhinosinusitis [EPOS] criteria for CRS).

    Methods: Four seasonal questionnaires were mailed to a stratified random sample of Geisinger primary care patients. Read More

    The urgent need for a harmonized severity scoring system for acute allergic reactions.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
    The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. Read More

    Characterization of CD34hematopoietic cells in systemic mastocytosis: Potential role in disease dissemination.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Cancer Research Centre (IBMCC USAL-CSIC), Cytometry Service (NUCLEUS) and Department of Medicine, University of Salamanca, Salamanca, Spain.
    Background: Recent studies show that most systemic mastocytosis (SM) patients, including indolent SM (ISM) with (ISMs+) and without skin lesions (ISMs-), carry the KIT D816V mutation in PB leukocytes. We investigated the potential association between the degree of involvement of BM hematopoiesis by the KIT D816V mutation and the distribution of different maturation-associated compartments of bone marrow (BM) and peripheral blood (PB) CD34hematopoietic precursors (HPC) in ISM and identified the specific PB cell compartments that carry this mutation.

    Methods: The distribution of different maturation-associated subsets of BM and PB CD34HPC from 64 newly diagnosed (KIT-mutated) ISM patients and 14 healthy controls was analyzed by flow cytometry. Read More

    The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Inserm, U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, Villejuif, France.
    Background: Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity. Read More

    Multidimensional endotypes of chronic rhinosinusitis and their association with treatment outcomes.
    Allergy 2018 Jan 13. Epub 2018 Jan 13.
    Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Background: The expression of chronic rhinosinusitis (CRS) is multidimensional. Disease heterogeneity in patients with CRS remains poorly understood. This study aimed to identify endotypes of CRS using cluster analysis by integrating multidimensional characteristics and to explore their association with treatment outcomes. Read More

    Prevalence of pollen-induced allergic rhinitis with high pollen exposure in grasslands of northern China.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore.
    Background: The aim of this study was to investigate the prevalence of epidemiologic and physician-diagnosed pollen-induced AR (PiAR) in the grasslands of northern China, and to study the impact of the intensity and time of pollen exposure on PiAR prevalence.

    Methods: A multistage, clustered and proportionately stratified random sampling with a field-interviewer administrated survey study was performed together with skin prick tests (SPT) and measurements of the daily pollen count.

    Results: A total of 6043 subjects completed the study; with a proportion of 32. Read More

    Lolium perenne peptide immunotherapy is well tolerated and elicits a protective B-cell response in seasonal allergic rhinitis patients.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, Respiratory Science Division, National Heart and Lung Institute, Imperial College, London, UK.
    Background: Systemic allergic reactions are a risk for allergen immunotherapy that utilizes intact allergen preparations. We evaluated the safety, efficacy and immune mechanisms of short-course treatment with adjuvant-free Lolium perenne peptides (LPP) following a 6-week dose-escalation protocol.

    Methods: In a prospective, dose-escalation study, 61 grass pollen-allergic patients received 2 subcutaneous injections of LPP once weekly for 6 weeks. Read More

    Usefulness of asthma predictive index in ascertaining asthma status of children using medical records: An explorative study.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Asthma Epidemiology Research Unit, Mayo Clinic, Rochester, MN, USA.
    Background: Frequent wheezing in original asthma predictive index (API) was defined by parental report of recurrent wheezing within 1 year during the first 3 years of life. The nature of frequent wheezing in children, particularly aged over 3 years, has not been studied. We aimed to assess the frequency and interval of wheezing to define frequent wheezing in ascertaining asthma for children using medical records. Read More

    Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
    Background: Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, thereby causing IgE-mediated food allergies.

    Objective: We examined whether skin barrier impairment following epicutaneous sensitization exacerbates food allergies.

    Methods: BALB/c mice were epicutaneously sensitized by repeated application of ovalbumin (OVA) to MC903-pretreated ear skin for 48 hours weekly and then intragastrically challenged with OVA. Read More

    Depressed mood is associated with loss of productivity in allergic rhinitis.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.
    Allergic rhinitis (AR) is associated with significant decreases in quality of life and productivity losses. We hypothesized that symptoms of AR may differentially associate with lost productivity due to AR. We performed a cross-sectional cohort study of 105 prospectively recruited patients with persistent AR. Read More

    EAACI Guidelines on Allergen Immunotherapy - Out With the Old and In With the New.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Allergy and Clinical Immunology, Transylvania University of Brasov, 500112, Brasov, Romania.
    Occurring in both developed and developing countries and across all ethnic groups and ages allergic diseases represent a global health problem. During the last few decades, there has been an increase in the prevalence of allergic diseases and it has been predicted that by 2025 half of the entire EU population will be affected [1]. The three major management strategies are avoidance, symptom control by pharmacotherapy and allergen immunotherapy (AIT). Read More

    Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE cross-reactivity.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
    Background: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterize the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity.

    Methods: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients' IgE reactivity. Read More

    Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Inmunotek, Alcalá de Henares, Spain.
    Background: Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison with native allergens. Read More

    Systemic IL-2/anti-IL-2Ab complex combined with sublingual immunotherapy suppresses experimental food allergy in mice through induction of mucosal regulatory T cells.
    Allergy 2018 Jan 10. Epub 2018 Jan 10.
    Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET y Universidad Nacional de La Plata, La Plata.
    Therapeutic tolerance restoration has been proven to modify food allergy in patients and animal models and although sublingual immunotherapy (SLIT) has showed promise, combined therapy may be necessary to achieve a strong and long-term tolerance. In this work, we combined SLIT with systemic administration of IL-2 associated with an anti-IL-2 monoclonal antibody (IL-2/anti-IL-2Ab complex or IL-2C) to reverse the IgE-mediated experimental allergy. Balb/c mice were sensitized with cholera toxin and milk proteins and orally challenged with allergen to elicit hypersensitivity reactions. Read More

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