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    1 OF 237

    Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.
    Allergy 2017 Nov 21. Epub 2017 Nov 21.
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
    IgE antibodies (Ab) specific to galactose-α-1,3-galactose (alpha-gal) are responsible for a delayed form of anaphylaxis that occurs 3 to 6 hours after red meat ingestion. In a unique prospective study of seventy participants referred with a diagnosis of idiopathic anaphylaxis (IA), six (9%) were found to have IgE to alpha-gal. Upon institution of a diet free of red meat, all patients had no further episodes of anaphylaxis. Read More

    RCAT reflects symptom control and quality of life in allergic rhinoconjunctivitis patients.
    Allergy 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, Cologne, Germany.
    Background: The Global Allergy and Asthma European Network (GA(2) LEN) Taskforce has requested more data on correlations between various Patient Reported Outcomes (PROs) in clinical trials on allergy. We compared three tools-the Rhinitis Control Assessment Test (RCAT), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Rhinitis Total Symptom Score (RTSS)-to determine whether the RCAT alone is a sufficient primary outcome parameter in clinical trials on allergic rhinoconjunctivitis.

    Methods: In two double-blind, placebo-controlled immunotherapy studies, 33 patients allergic to grass pollen and 94 to birch pollen completed two questionnaires (RCAT and RQLQ) and kept their own symptom diary from which the RTSS was calculated. Read More

    Blocking antibodies induced by allergen-specific immunotherapy ameliorate allergic airway disease in a human/mouse chimeric model.
    Allergy 2017 Nov 21. Epub 2017 Nov 21.
    Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
    Background: Allergen-specific immunotherapy (AIT) induces specific blocking antibodies (Ab) which are claimed to prevent IgE-mediated reactions to allergens. Additionally, AIT modulates cellular responses to allergens, e.g. Read More

    Maternal hypothyroidism in the perinatal period and childhood asthma in the offspring.
    Allergy 2017 Nov 21. Epub 2017 Nov 21.
    The National Center for Register-based Research, Aarhus University, Aarhus, Denmark.
    Background: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in the present study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. Read More


    Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls.
    Allergy 2017 Nov 20. Epub 2017 Nov 20.
    Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany.
    Background: Histamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine-rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls. Read More

    A randomized, double-blind, placebo-controlled, dose-finding trial with Lolium perenne peptide immunotherapy.
    Allergy 2017 Nov 18. Epub 2017 Nov 18.
    Immunomodulation and Tolerance Group, Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.
    Background: A novel subcutaneous allergen immunotherapy formulation (gpASIT+(™) ) containing Lolium perenne peptides (LPP) and having a short up-dosing phase has been developed to treat grass pollen-induced seasonal allergic rhinoconjunctivitis. We investigated peptide immunotherapy containing the hydrolysate from perennial ryegrass allergens for the optimum dose in terms of clinical efficacy, immunogenicity, and safety.

    Methods: This prospective, double-blind, placebo-controlled, phase IIb, parallel, four-arm, dose-finding study randomized 198 grass pollen-allergic adults to receive placebo or cumulative doses of 70, 170, or 370 μg LPP. Read More

    Rhinitis and its Impact on Quality of Life in Swimmers.
    Allergy 2017 Nov 18. Epub 2017 Nov 18.
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands.
    Introduction: Limited data suggest that swimmers might be affected by rhinitis significantly more often than the general population. This can have impact on quality of life but also on performance. The aim of the present study was to determine the prevalence and impact of QOL of rhinitis in swimming compared to non-swimming athletes and controls. Read More

    Poor agreement in questionnaire-based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity.
    Allergy 2017 Nov 18. Epub 2017 Nov 18.
    Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
    Background: The association between atopic dermatitis (AD) and cardio-metabolic risk factors is not yet established. Furthermore, no validated questionnaire-based method of identifying adults with AD is currently available.

    Objectives: To assess the cardio-metabolic risk in adults with a history of AD by using three different questionnaire-based diagnostic criteria. Read More

    Allergen manufacturing and quality aspects for allergen immunotherapy in Europe and the United States: An analysis from the EAACI AIT Guidelines Project.
    Allergy 2017 Nov 17. Epub 2017 Nov 17.
    Paul-Ehrlich-Institut, Langen, Germany.
    Adequate quality is essential for any medicinal product to be eligible for marketing. Quality includes verification of the identity, content and purity of a medicinal product in combination with a specified production process and its control. Allergen products derived from natural sources require particular considerations to ensure adequate quality. Read More

    Quality of life is significantly impaired in non-allergic rhinitis patients.
    Allergy 2017 Nov 13. Epub 2017 Nov 13.
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands.
    Background: In contrast to the well-known significant impairment of quality of life (QoL) in allergic rhinitis (AR), the degree of impairment in QoL in non-allergic rhinitis (NAR) remained unknown for a long time, due to a lack of a validated questionnaire to assess QoL in the NAR patient group. In this study a validation for the mini-RQLQ questionnaire in NAR patients was performed, followed by an assessment of QoL in NAR patients compared to AR and healthy controls. Secondly, use of medication and treatment satisfaction in AR and NAR was assessed. Read More

    Gluten sensitivities and the allergist: Threshing the grain from the husks.
    Allergy 2017 Nov 13. Epub 2017 Nov 13.
    Allergy& Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
    "Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0. Read More

    CRP is linked to disease activity, impact and response to treatment in patients with chronic spontaneous urticaria.
    Allergy 2017 Nov 12. Epub 2017 Nov 12.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Berlin, Germany.
    Background: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria. Here, we retrospectively analyzed data from 1,253 CSU patients from two centers to answer the following questions: 1) What is the prevalence of elevated levels of CRP in CSU? 2) Why do CSU patients show elevated levels of CRP? 3) Are elevated CRP levels relevant?

    Methods: Serum levels of CRP were measured by the nephelometric method. We collected information regarding various laboratory tests including ESR, CBC with differential, D-dimer, fibrinogen, C3, C4, IL-6 etc. Read More

    [AN ADULT CASE OF EGG ALLERGY TREATED WITH RUSH ORAL IMMUNOTHERAPY].
    Arerugi 2017 ;66(9):1181-1184
    Department of Allergy, Kanagawa Children's Medical Center.
    A 26-year-old female patient exhibited symptoms associated with egg allergy, which had been present since early childhood. The patient requested the treatment of egg allergy and was admitted to our hospital for rush oral immunotherapy. The threshold was determined by an oral food challenge test, after positive results on a double-blind food challenge test. Read More

    [CLINICAL EFFICACY OF SUBLINGUAL IMMUNOTHERAPY IN THE THIRD TREATED YEAR WITH JAPANESE CEDAR POLLINOSIS IN 2017].
    Arerugi 2017 ;66(9):1172-1180
    Department of Otorhinolaryngology, Shiga Medical University.
    It past 3 years in 2017 after the first purchase of the drug for sublingual immunotherapy (SLIT) for Japanese Cedar pollinosis (JCP). We reported the clinical efficacy of SLIT in the first and the second treated year.

    Purpose: The purpose of this study is to clear the clinical efficacy of SLIT in the third treated year by comparing with other therapies, such as subcutaneous immunotherapy (SCIT), or other pharmacotherapy. Read More

    [ANALYSIS OF BACKGROUNDS AND LEVEL OF UNDERSTANDING OF TREATMENT OF POOR ADHERENCE AND DROPOUT CASES ON SUBLINGUAL IMMUNOTHERAPY FOR JAPANESE CEDAR POLLINOSIS IN THE FIRST FOLLOW-UP YEAR].
    Arerugi 2017 ;66(9):1165-1171
    Department of Otorhinolaryngology, Saitama Medical University.
    Background: We considered the factors of poor adherence to and dropout from sublingual immunotherapy (SLIT) by verifying patient backgrounds 1 year after start of treatment.

    Methods: We recruited 38 patients who began SLIT between November 2014 and September 2015. We analyzed their attributes and level of understanding of the treatment, and conducted a self-reported survey on factors behind dropout cases and poor adherence cases. Read More

    NUT Co Reactivity - Acquiring Knowledge for Elimination Recommendations (NUT CRACKER) Study.
    Allergy 2017 Nov 11. Epub 2017 Nov 11.
    Institute of Allergy, Immunology and Pediatric Pulmonology, Assaf-Harofeh Medical Center, Israel.
    Background: Ambiguities exist regarding the diagnosis of tree-nut allergy, necessitating either elimination or performance of oral food challenges (OFC).

    Objective: To examine the co-incidences of allergies among tree-nuts and improve diagnostic testing to minimize the need for OFC.

    Methods: Eighty three patients prospectively evaluated for walnut, pecan, cashew, pistachio, hazelnut and almond allergy. Read More

    Strong and frequent T-cell responses to the minor allergen Phl p 12 in Spanish patients IgE-sensitized to Profilins.
    Allergy 2017 Nov 9. Epub 2017 Nov 9.
    Global Research, ALK-Abelló, 2970, Hørsholm, Denmark.
    Background: Profilins are dominant pan-allergens known to cause cross-sensitization, leading to clinical symptoms such as the pollen food syndrome. This study aims to determine the T-cell response to Phl p 12 in profilin-sensitized patients, by measuring the prevalence, strength and cross-reactivity to clinically relevant profilins.

    Methods: The release of Phl p allergens from pollen was determined by mass spectrometry and immunochemistry. Read More

    MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite allergic rhinitis.
    Allergy 2017 Nov 9. Epub 2017 Nov 9.
    Laboratory of Clinical Immunology, Dpt. Microbiology & Immunology, KU Leuven, Leuven, Belgium.
    Background: Nasal hyperreactivity (NHR) is an important clinical feature of allergic rhinitis (AR). The efficacy of MP29-02 (azelastine hydrochloride (AZE) and fluticasone propionate (FP)) nasal spray on local inflammatory mediators and NHR in AR is unknown. We tested if MP29-02 decreases inflammatory mediators and NHR in AR and if this effect is due to restoration of nasal epithelial barrier function. Read More

    The Utility Of Monitoring Trimellitic Anhydride (TMA)-Specific IgG To Predict IgE-mediated Sensitization in An Immunosurveillance Program.
    Allergy 2017 Nov 8. Epub 2017 Nov 8.
    University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Immunology/Allergy Section.
    Background: Workplace exposure to Trimellitic Anhydride (TMA) can elicit TMA-specific IgE (sIgE), which may lead to occupational asthma (OA). An occupational immunosurveillance program (OISP) has been implemented to monitor TMA exposure and immunologic outcomes. The purpose of this study was to determine whether TMA-specific IgG (sIgG) responses can discriminate between TMA-exposed workers with and without sIgE responses. Read More

    What can we learn in drug allergy management from World Health Organization's international classifications?
    Allergy 2017 Nov 6. Epub 2017 Nov 6.
    University Hospital of Montpellier, Montpellier, France.
    Drug hypersensitivity reactions (DHRs) represent growing health problem worldwide, affecting more than 7% of the general population, and represent an important public health problem. However, knowledge in DHRs morbidity and mortality epidemiological data is still not optimal and international comparable standards remain poorly accessed. Institutional databases worldwide increasingly use the WHO International Classification of Diseases (ICD) system to classify diagnoses, health services utilization, and death data. Read More

    Economic evidence for nonpharmacological asthma management interventions: A systematic review.
    Allergy 2017 Nov 6. Epub 2017 Nov 6.
    Norwich Medical School, University of East Anglia, Norwich, UK.
    Asthma management, education and environmental interventions have been reported as cost-effective in a previous review (Pharm Pract (Granada), 2014;12:493), but methods used to estimate costs and outcomes were not discussed in detail. This review updates the previous review by providing economic evidence on the cost-effectiveness of studies identified after 2012, and a detailed assessment of the methods used in all identified studies. Twelve databases were searched from 1990 to January 2016, and studies included economic evaluations, asthma subjects and nonpharmacological interventions written in English. Read More

    Influenza burden, prevention and treatment in asthma - a scoping review by the EAACI Influenza in Asthma Task Force.
    Allergy 2017 Nov 6. Epub 2017 Nov 6.
    Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg University Hospital Giessen, Marburg, Marburg, Germany.
    To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Read More

    Early life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis.
    Allergy 2017 Nov 6. Epub 2017 Nov 6.
    Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands.
    This study systematically reviewed and quantified the relationship between exposure to antibiotics during the first 2 years of life and the risk of allergies/atopies including hay fever, eczema, food allergy, positive skin prick testing (SPT) or elevated allergen-specific serum/plasma immunoglobulin (Ig) E levels later in life. PubMed and Web of Science databases were searched for observational studies published from January 1966 through November 11, 2015. Overall pooled estimates of the odds ratios (ORs) were obtained using fixed or random-effects models. Read More

    Clinical implications of mast cell involvement in allergic conjunctivitis.
    Allergy 2017 Nov 6. Epub 2017 Nov 6.
    Rutgers University Center for Environmental Prediction, New Brunswick, NJ, USA.
    The conjunctiva is a common site for the allergic inflammatory response due to it being highly vascularized, having constant exposure to environmental pollutants and allergenic pollens and having a unique conjunctival associated lymphoid tissue. The primary morbidity of anterior surface conjunctival disorders that include allergic conjunctivitis and tear film disorders is associated with its high frequency of involvement rather than its severity, although the more chronic forms can involve the cornea and lead to sight-threatening conditions. Ocular allergy is associated with IgE-mediated mast cell activation in conjunctival tissue leading to the release of preformed mediators including histamine and proteases and subsequent de novo formation of lipid-derived mediators and cytokines that trigger a cascade of cellular and molecular events leading to extensive migration and infiltration of inflammatory cells to the ocular surface. Read More

    Risk factors for asthma after infant bronchiolitis.
    Allergy 2017 Nov 4. Epub 2017 Nov 4.
    Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.
    Background: Five studies carried out after bronchiolitis at less than 24 months of age, with a follow up of more than 10 years, reported that atopic dermatitis, family asthma, early-life exposure to tobacco smoke and rhinovirus aetiology were early-life risk factors for later asthma. This study evaluated the long-term outcome at 11-13 years of age of children who were hospitalised for bronchiolitis in early infancy.

    Methods: We previously prospectively followed 166 children hospitalised for bronchiolitis at less than six months of age until 5-7 years of age. Read More

    The clinical response to omalizumab in CSU patients is linked to and predicted by IgE levels and their change.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Dermatology and Allergy Dermatological Allergology, Charité - Universitätsmedizin Berlin, Germany.
    Background: Omalizumab is an effective and well-tolerated treatment for chronic spontaneous urticaria (CSU). Markers and predictors of response are largely unknown, but needed to optimize omalizumab treatment. Omalizumab targets IgE, and IgE levels may be linked to the effects of treatment. Read More

    Intranasal administration of allergen increases specific IgE whereas intranasal Omalizumab does not increase serum IgE levels - a pilot study.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Otorhinolaryngology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
    Background: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases of IgE antibody levels.

    Objective: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab or placebo on the levels of total and allergen-specific IgE in patients with birch pollen allergy.

    Methods: Based on the fact that intranasal allergen application induces rises of systemic allergen-specific IgE we performed a double-blind placebo-controlled pilot trial in which birch pollen allergic subjects were challenged intranasally with omalizumab, placebo or birch pollen allergen Bet v 1. Read More

    Pigeon tick bite: A neglected cause of idiopathic nocturnal anaphylaxis.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
    Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas reflexus from several European countries. Read More

    Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin-homing and systemic T-cell populations.
    Allergy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Dermatology and the Laboratory for Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Background: Characterizing blood profile of alopecia areata (AA) is not only important for treatment advancements, but also for possibly identifying peripheral biomarkers that will eliminate the need for scalp biopsies. We aimed to compare frequencies of skin homing (CLA(+) ) vs. systemic (CLA(-) ) "polar" CD4(+) and CD8(+) and activated T-cell subsets in AA vs. Read More

    RItA: The Italian severe/uncontrolled asthma registry.
    Allergy 2017 Oct 26. Epub 2017 Oct 26.
    Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy.
    Background: The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, and inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care.

    Methods: Four hundred and ninety three adult patients from 27 Italian centers (recruited in 2011-2014) were analyzed.

    Results: Mean age was 53. Read More

    Cockroach is a major cross-reactive allergen source in shrimp-sensitized rural children in southern China.
    Allergy 2017 Oct 26. Epub 2017 Oct 26.
    Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    Background: Little is known about the prevalence of food allergy (FA) in China.

    Objective: To investigate the prevalence of FA and its disparity between urban and rural areas in southern China.

    Methods: Europrevall questionnaire responses were obtained from 5,542 school-age-children in urban Guangzhou and 5,319 in rural Shaoguan. Read More

    Emerging roles of innate lymphoid cells in inflammatory diseases: Clinical implications.
    Allergy 2017 Oct 25. Epub 2017 Oct 25.
    Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands.
    Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and nonallergic inflammatory diseases due to their location at barrier surfaces within the airways, gut, and skin, and they respond to cytokines produced by activated cells in their local environment. Innate lymphoid cells contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. Read More

    Omalizumab Rapidly Improves Angioedema-Related Quality of Life in Adult Patients with Chronic Spontaneous Urticaria: X-ACT Study Data.
    Allergy 2017 Oct 23. Epub 2017 Oct 23.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.
    Background: The X-ACT study aims to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1 -antihistamines.

    Methods: In X-ACT, a phase III, double-blind, placebo-controlled study, CSU patients (18-75 years) with ≥4 angioedema episodes during the 6 months before inclusion were randomized (1:1) to receive omalizumab 300 mg or placebo every 4 weeks for 28 weeks. Angioedema-related QoL, skin-related QoL impairment, and psychological well-being were assessed. Read More

    Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules.
    Allergy 2017 Oct 20. Epub 2017 Oct 20.
    Dept. of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany.
    Background: Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed at analyzing the characteristics of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of such molecules in childhood. Read More

    Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet.
    Allergy 2017 Oct 20. Epub 2017 Oct 20.
    Paediatric Allergy Unit, Hospital Infantil Universitario Gregorio Marañón, Madrid, Spain.
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity usually due to cow's milk or soy. Recent researches show that fish is 1 of the most important triggers of FPIES in the Mediterranean countries. Due to the risk of multiple-food FPIES, avoiding foods in the same category or that often occur together may be reasonable. Read More

    The longitudinal impact of probiotic and peanut oral immunotherapy on health-related quality of life.
    Allergy 2017 Oct 20. Epub 2017 Oct 20.
    Murdoch Children's Research Institute, Melbourne, Vic., Australia.
    Background: We previously reported that probiotic and peanut oral immunotherapy (PPOIT) was effective at inducing sustained unresponsiveness compared with placebo in a double-blind, placebo-controlled randomized trial. This study evaluated the impact of PPOIT on health-related quality of life (HRQL).

    Method: Fifty-one participants (PPOIT 24; placebo 27) from the PPOIT trial completed Food Allergy Quality of Life Questionnaire (FAQLQ-PF) and Food Allergy Independent Measure (FAIM) at pre-treatment, end-of-treatment and 3 months after end-of-treatment. Read More

    Different functional genes of upper airway microbiome associated with natural course of childhood asthma.
    Allergy 2017 Oct 20. Epub 2017 Oct 20.
    Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background: Microbial colonization of the airway plays a role in the pathogenesis of asthma; however, the effect of the upper airway microbiome on childhood asthma is not fully understood. We analyzed the metagenome of airway microbiome to understand the associated role of upper airway microbiome with the natural course of childhood asthma.

    Methods: Nasopharyngeal swabs were collected from children with asthma, those in asthma remission, and control groups. Read More

    Quantitative analysis of multiple elements in healthy and remodeled epithelium from human upper airway mucosa using nuclear microscopy.
    Allergy 2017 Oct 11. Epub 2017 Oct 11.
    Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Elements are vital in airway mucosal physiology and pathology, but their distribution and levels in the mucosa remain unclear. This study uses the state-of-the-art nuclear microscopy facility to map and quantify multiple elements in the histology sections of nasal mucosa from patients with nasal polyps or inverted papilloma. Our results demonstrate that P and Ca are the most abundant elements in mucosa and their distinct difference between epithelial and subepithelial regions; more importantly, our results reveal decreased amounts of Cu and Zn in the remodeled epithelium as compared to the normal epithelium. Read More

    CRD and beyond: multivariable regression models to predict severity of hazelnut allergy.
    Allergy 2017 Oct 7. Epub 2017 Oct 7.
    Allergy Unit, Department of Dermatology, University Hospital Zürich, Switzerland.
    Background: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity.

    Aim: To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to improve predictive accuracy. Read More

    Complete kinetic follow-up of symptoms and complement parameters during a hereditary angioedema attack.
    Allergy 2017 Oct 7. Epub 2017 Oct 7.
    Research Laboratory, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
    We studied the kinetics of C1-inhibitor (C1-INH) and other complement parameters in a self-limited edematous attack (EA) in a patient with hereditary angioedema due to C1-INH deficiency to better understand the pathomechanism of the evolution, course, and complete resolution of EAs. C1-INH concentration and functional activity (C1-INHc+f ), C1(q,r,s), C3, C4, C3a, C4a, C5a, and SC5b-9 levels were measured in blood samples obtained during the 96-hour observation period. The highest C1-INHc+f , C4, and C1(q,r,s) levels were measured at baseline, and their continuous decrease was observed during the entire observation period. Read More

    Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use.
    Allergy 2017 Oct 4. Epub 2017 Oct 4.
    Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
    Background: Epidemiologic evidence indicates a relevant association between atopic dermatitis (AD) and attention-deficit/hyperactivity disorder (ADHD). Underlying mechanisms and ways to best identify subgroups of AD patients at risk for ADHD are poorly understood.

    Aims Of The Study: To compare sociodemographic, clinical and psychosocial characteristics of children with AD, ADHD, comorbid AD/ADHD and age-matched healthy controls and to investigate aspects of AD related to ADHD symptoms. Read More

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