PubFacts Top Author
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12,004 results match your criteria Allergy[Journal]
Allergy 2018 Jun 14. Epub 2018 Jun 14.
Department of Pathology, University of Pittsburgh, School of Medicine, University of Pittsburgh Medical Center.
Background: The receptor for advanced glycation endproducts (RAGE) has been implicated as a critical molecule in the pathogenesis of experimental asthma/allergic airway inflammation (AAI). It has been previously shown that RAGE acts both upstream of interleukin-33 (IL-33) release and downstream of IL-33 release via RAGE-dependent IL-33 induced accumulation of type 2 innate lymphoid cells (ILC2s) in the lungs, which perpetuate type 2 inflammation and mucus metaplasia. However, the mechanism by which RAGE mediates downstream IL-33 induced type 2 inflammatory responses is unknown. Read More
Allergy 2018 Jun 13. Epub 2018 Jun 13.
Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Allergy 2018 Jun 10. Epub 2018 Jun 10.
Centre of Microbial and Plant Genetics, Department of Microbial and Molecular Systems (M²S), KU, Leuven, Belgium.
Background: There is an increasing interest in targeted application of probiotic bacteria for prevention and treatment of airway diseases, including allergies. Here, we investigated the beneficial effects of preventive intranasal treatment with probiotics Lactobacillus rhamnosus GG and L. rhamnosus GR-1 in a mouse model of allergic asthma. Read More
Allergy 2018 Jun 9. Epub 2018 Jun 9.
Division of Pharmacoepidemiology and Clinical Pharmacology, Faculty of Science, Utrecht University, Utrecht, Netherlands.
Allergy 2018 Jun 9. Epub 2018 Jun 9.
Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases. National Institutes of Health, 4 Memorial Drive, Building 4, Room 138, Bethesda, MD, 20892, U.S.A.
Allergy 2018 Jun 9. Epub 2018 Jun 9.
Department of Dermatology/Allergology, University Medical Center Utrecht, The Netherlands.
Allergy 2018 Jun 9. Epub 2018 Jun 9.
Ambulatorio di Allergologia, Clinica San Carlo, Milan, Italy.
Allergy 2018 Jun 5. Epub 2018 Jun 5.
Department of Otolaryngology, National University of Singapore, Singapore.
United airways disease (UAD) is the concept that the upper and lower airways, which are anatomically and immunologically related, form a single organ. According to this concept, upper and lower airway diseases are frequently comorbid because they reflect manifestations of a single underlying disease at different sites of the respiratory tract. Allergic asthma-allergic rhinitis is the archetypal UAD, but emerging data indicate that UAD is a heterogeneous condition and consists of multiple phenotypes (observable clinical characteristics) and endotypes (pathobiologic mechanisms). Read More
Allergy 2018 Jun 5. Epub 2018 Jun 5.
Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany.
Allergy 2018 Jun 5. Epub 2018 Jun 5.
Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
Probiotics are live microorganisms that confer a health benefit on the host when applied in adequate amounts. The therapeutic effects of probiotics have been mostly studied in the gastrointestinal tract, but recent evidence points towards the potential of these bacteria to prevent and/or treat chronic airway diseases. In this review, possible mechanisms of action of probiotics in the airways are described, with a particular focus on their capacity to modulate the epithelial barrier function and their mode of interaction with the immune system. Read More
Allergy 2018 Jun 4. Epub 2018 Jun 4.
Department of Chronic Disease Epidemiology, Yale University School of Public Health, New Haven, USA.
Allergy 2018 May 30. Epub 2018 May 30.
Allergy and Lung Health Unit, School of Population and Global health, University of Melbourne, Melbourne, VIC, Australia.
Allergy 2018 May 30. Epub 2018 May 30.
Immunology-Allergology-Rheumatology, University of Antwerp - University Hospital of Antwerp, Antwerp, Belgium.
Allergy 2018 May 26. Epub 2018 May 26.
Medical Support Center for the Japan Environment and Children's Study, National Center for Child Health and Development, Tokyo, Japan.
Allergy 2018 May 26. Epub 2018 May 26.
Upper Airways Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University Hospital, Ghent, Belgium.
Background: Mucin over-secretion is a significant characteristic of chronic rhinosinusitis with nasal polyps (CRSwNP). The present study aimed to investigate the relationship between Th2 cytokines and MUC5AC or MUC5B, and the mechanism of mucin over-secretion in the type-2 inflammatory endotype of CRSwNP.
Methods: Main Th-cell cytokines, associated mediators and mucins were determined in the homogenates of nasal polyp samples from 21 CRSwNP patients and inferior turbinate samples from 8 controls, by ELISA or UniCAP system. Read More
Allergy 2018 May 23. Epub 2018 May 23.
German Pollen Information Service Foundation, Berlin, Germany.
Background: The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergen exposure time periods. We evaluate pollen data from Germany to examine the new definitions on pollen season and peak pollen period start and end as proposed by the European Academy of Allergy and Clinical Immunology (EAACI) in a recently published Position Paper. The aim was to demonstrate the ability of these definitions to mirror symptom loads for grass and birch pollen-induced allergic rhinitis based on real-life data. Read More
Allergy 2018 May 23. Epub 2018 May 23.
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Background: Recent data associate eosinophilic esophagitis (EoE) with IgG4 rather than IgE, but its significance and function have not been determined. Our aims were to measure esophageal IgG4 levels and to determine functional correlations as assessed by histologic and transcriptome analyses.
Methods: This case-control study included pediatric subjects with EoE (≥15 eosinophils/HPF) and non-EoE controls. Read More
Allergy 2018 May 22. Epub 2018 May 22.
McMaster Immunology Research Centre (MIRC), Dept. of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
Background: The generation of IgE-mediated food allergy in humans is silent, and only diagnosed upon manifestation of clinical symptoms. While experimental models have been used to investigate some mechanisms of allergic sensitization, the generation of humoral immunity and memory remain to be elucidated. Here, we defined the evolution of allergen-specific B cell responses during epicutaneous sensitization to foods. Read More
Allergy 2018 05 22. Epub 2018 May 22.
Pediatric Intensive Care Unit, CHU Lille, Lille, France.
Allergy 2018 May 22. Epub 2018 May 22.
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Chronic viral infections including those by hepatitis B (CHB) virus and hepatitis C (CHC) virus have been reported to be comorbidities of chronic spontaneous urticaria (CSU). Here, we performed the first comprehensive review of the peer-reviewed literature (PubMed, Web of Science and Google Scholar) on the prevalence of CHB and CHC in patients with CSU and vice versa. The prevalence of CHB and CHC in CSU does not appear to be increased. Read More
Allergy 2018 May 22. Epub 2018 May 22.
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.
Background: Compositional changes of the early life gut microbiota have been implicated in IgE-associated allergic disease but there is lack of longitudinal studies. We examined gut microbiota development from infancy to school age in relation to onset of IgE-associated allergic diseases. At 8 years of age, we also examined the relationship between gut microbiota and T-cell regulation, estimated as responses to polyclonal T-cell activation. Read More
Allergy 2018 May 22. Epub 2018 May 22.
Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
Allergy 2018 May 19. Epub 2018 May 19.
Clinic for Child and Adolescent Medicine, Allergology, Pneumonology and Cystic Fibrosis, Goethe University Frankfurt am Main, Frankfurt, Germany.
Background: The Birch Allergoid, Tyrosine Adsorbate, Monophosphoryl Lipid A (POLLINEX Quattro Plus 1.0 ml Birch 100%) is an effective, well-tolerated short course subcutaneous immunotherapy. We performed 2 phase II studies to determine its optimal cumulative dose. Read More
Allergy 2018 May 19. Epub 2018 May 19.
Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA - Institut de Biologie François Jacob, 2 rue Gaston Cremieux, Evry, France.
Background: Epicutaneous immunotherapy (EPIT) is a promising method for treating food allergies. In animal models, EPIT induces sustained unresponsiveness and prevents further sensitization mediated by Tregs. Here, we elucidate the mechanisms underlying the therapeutic effect of EPIT, by characterizing the kinetics of DNA methylation changes in sorted cells from spleen and blood and by evaluating its persistence and bystander effect compared to oral immunotherapy (OIT). Read More
Allergy 2018 May 19. Epub 2018 May 19.
Laboratory of Immunoregulation and Immunopathology, Institut Necker-Enfants Malades, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8253, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR 1151 and Université Paris Descartes Sorbonne Paris Cité, 75015, Paris, France.
Background: Basophils are commonly associated with allergic responses because of their ability to produce large amounts of pro-Th2 cytokines and histamine. However, the mechanisms through which bone marrow-resident basophils (BMRB) become fully competent cytokine and histamine producers in response to IgE crosslinking are poorly understood. Here, we sought to determine the role of IL-3 in promoting pro-Th2 basophils. Read More
Allergy 2018 May 18. Epub 2018 May 18.
Manitoba Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Children's Hospital Research Institute of Manitoba, Canada.
Allergies originate early in life and food sensitization is often the first manifestation of allergic disease (1). Breastfeeding has been inconsistently associated with allergic conditions (2). These inconsistencies could reflect differences in human milk composition, which varies across different settings and populations. Read More
Arerugi 2018 ;67(3):219-223
Oita Children's Hospital.
We treated a 13-year-old girl who developed dyspnea after ingestion of okonomiyaki, a Japanese savory pancake prepared from takoyaki flour mix that was opened several months ago and had been stored at ambient temperature. She was found to be sensitized to mite antigen, and microscopic examination of the flour specimen revealed contamination with mites. Therefore, she was diagnosed with oral mite anaphylaxis (OMA). Read More
Arerugi 2018 ;67(3):211-218
Department of Allergy, Kanagawa Children's Medical Center.
Backgrounds: Recently, patients with oral allergy syndrome (OAS) to fruits or vegetables caused by pollenfood allergy syndrome (PFAS) have increased nationwide. We examined effectiveness of SCIT using birch pollen extract for PFAS.
Methods: A total of 19 patients (9 male and 10 female) underwent SCIT with birch pollen extract from August 2011 to August 2016. Read More
Arerugi 2018 ;67(3):202-210
Department of Pediatric Surgery, Tokyo Jikei University School of Medicine Hospital.
Background: There are no reports on the prevalence and social acceptance of food allergies (FAs) and FAinduced symptoms in nursery schools in Japan.
Purpose: The purpose of this study is to clarify the current status of FA among children in nurseries.
Methods: Investigations were conducted in childcare facilities nationwide through survey request forms found on the Web page or sent via post. Read More