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Allergy 2021 Jun 22. Epub 2021 Jun 22.

Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, and Allergy Unit, Clinic for Dermatology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.

Atopic dermatitis (AD) typically develops in infancy and affects up to 20% of children in high-income countries (1). Immediate (IgE-mediated) food allergy (FA) affects around 3% of children (2). Children with AD are at higher risk of immediate-type FA (3, 4). Read More

Allergy 2021 Jun 22. Epub 2021 Jun 22.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) has been associated with cutaneous findings, some being the result of drug hypersensitivity reactions such as maculopapular drug rashes (MDR). The aim of this study was to investigate whether COVID-19 is associated with the development of the MDR.

Methods: Blood and skin samples from COVID-19 patients (based on a positive nasopharyngeal PCR) suffering from MDR (COVID-MDR), healthy controls, non-COVID-19-related patients with drug rash with eosinophilia and systemic symptoms (DRESS), and MDR were analyzed. Read More

Allergy 2021 Jun 22. Epub 2021 Jun 22.

Department of Biomedicine, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.

Biologicals are crucial targeted therapeutic agents in oncological, immunological, and inflammatory diseases, and their use in clinical practice is broadening. In recent years, the spread of Personalized Precision Medicine has facilitated a proliferation of new treatment options, especially biologicals. Consequently, biologicals are now among the drugs that most frequently cause hypersensitivity reactions (HSRs). Read More

Allergy 2021 06 9;76(6):1813-1824. Epub 2021 Mar 9.

Dermatology Unit, Department of MedicalSpecialties, Arcispedale Santa Maria Nuova-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background: Few and small studies have described the management of immunomodulant/immunosuppressive therapies or phototherapy in atopic dermatitis (AD) patients during coronavirus disease 2019 (COVID-19) pandemic.

Methods: A national registry, named DA-COVID-19 and involving 35 Italian dermatology units, was established in order to evaluate the impact of COVID-19 pandemic on the management of adult AD patients treated with systemic immunomodulant/immunosuppressive medications or phototherapy. Demographic and clinical data were obtained at different timepoints by teledermatology during COVID-19 pandemic, when regular visits were not allowed due to sanitary restrictions. Read More

Allergy 2021 Jun 18. Epub 2021 Jun 18.

Department of Adult and Pediatric Dermatology, Bordeaux University Hospitals, France.

Arerugi 2021 ;70(4):327-334

Arerugi 2021 ;70(4):323-324

Arerugi 2021 ;70(4):321-322

Arerugi 2021 ;70(4):315-320

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

At the time of writing of this manuscript, four biologics were clinically available for treatment against severe asthma. The choice of four biologics has been taking into account of the results of several type 2 inflammationrelated biomarkers, and the comorbidities of asthma, such as eosinophilic chronic rhinosinusitis, allergic rhinitis, and atopic dermatitis.In this study, we have experienced a case of severe asthma complicated by eosinophilic chronic rhinosinusitis and eosinophilic otitis media, resulting in the use of four biologics, and we observed differential response of upper and lower airways. Read More

Arerugi 2021 ;70(4):310-314

Department of Pediatrics, Saitama Medical University Hospital.

A 12-year-old boy visited our hospital with complaints of chronic cough and dyspnea. Chest X-ray and CT revealed diffuse granular shadow in the bilateral lung fields and "Tree-in-bud appearance" in the peripheral airways, respectively. Sinusitis was present, and restrictive disorder was predominantly found in pulmonary function. Read More

Arerugi 2021 ;70(4):302-309

Respiratory Medicine, National Hospital Organization Nanao Hospital.

The case subject was a 19-year-old exchange student from Thailand who had undergone tuberculosis (TB) treatment twice. Upon observing a shadow in the right upper lung, the patient was referred for examination; however, acid-fast bacteria test results were negative. Furthermore, high levels of total IgE and anti-aspergillus IgE and IgG antibodies were found. Read More

Arerugi 2021 ;70(4):293-301

Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital.

Background: To clarify the status of admission to facilities for food allergy (FA) children.

Methods: Guardians of FA children who underwent oral food challenges at Sagamihara National Hospital from September to December 2018 were enrolled. We surveyed the experience of refusal to enter facilities, the reason for refusal and so on using a self-administered questionnaire. Read More

Arerugi 2021 ;70(4):289-292

Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development.

Arerugi 2021 ;70(4):282-288

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences.

Arerugi 2021 ;70(4):274-281

Clinical Reseach Center, Shonan-Kamakura General Hospital.

Arerugi 2021 ;70(4):271-273

Division of Respiratory Medicine, Third Department of Medicine, Teikyo University Chiba Medical Center.

Arerugi 2021 ;70(4):263-269

Department of Pediatrics, National Hospital Organization Nagoya Medical Center.

Arerugi 2021 ;70(4):255-262

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine.

Allergy 2021 Jun 15. Epub 2021 Jun 15.

Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Allergy 2021 Jun 15. Epub 2021 Jun 15.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.

Allergy 2021 Jun;76(6):1945

Allergy 2021 Jun;76(6):1946-1947

Department of Immunology, Mie University Graduate School of Medicine, Tsu, Japan.

Allergy 2021 06;76(6):1611-1616

Allergy 2021 06;76(6):1943-1944

Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.

Allergy 2021 06;76(6):1934-1937

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Allergy 2021 06;76(6):1938-1940

Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany.

Allergy 2021 06;76(6):1932-1933

Department of Internal Medicine and Allergology, University Medical Center Groningen, Groningen, The Netherlands.

Allergy 2021 06;76(6):1941-1942

Department of Allergology, Diakonessenhuis, Utrecht, The Netherlands.

Allergy 2021 Jun 4. Epub 2021 Jun 4.

Japan Anti-Tuberculosis Association Fukujuji Hospital, Tokyo, Japan.

Allergy 2021 Jun 4. Epub 2021 Jun 4.

Firestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, ON, Canada.