A PHP Error was encountered

Severity: Notice

Message: Undefined variable: arrPubMedArticleOutput

Filename: helpers/my_audit_helper.php

Line Number: 3660

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3660
Function: _error_handler

File: /var/www/html/application/controllers/Search.php
Line: 70
Function: pubMedSearch_Global

File: /var/www/html/index.php
Line: 320
Function: require_once

Allergology international : official jo... Publications | PubFacts

13,938 results match your criteria Allergology international : official journal of the Japanese Society of Allergology[Journal]


Staphylococcus aureus and Host Immunity in Recurrent Furunculosis.

Dermatology 2019 Apr 17:1-11. Epub 2019 Apr 17.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000499184DOI Listing

Diagnosis and treatment of IgE-mediated insulin hypersensitivity: two case reports.

J Dtsch Dermatol Ges 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Eberhard Karls University, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.13832DOI Listing
April 2019
1 Read

Normal and keloid fibroblasts are differentially influenced by IFN-γ and triamcinolone as well as by their combination.

Wound Repair Regen 2019 Apr 17. Epub 2019 Apr 17.

University Hospital Frankfurt Goethe University, Frankfurt/Main, Department of Dermatology, Venereology and Allergology, Germany.

Impaired wound healing as well as imbalanced cell proliferation and extracellular matrix synthesis and degeneration can cause aberrant scarring. The most severe impacts of such scarring on patients' lives are stigmatization and physical restriction. Although, a broad variety of combinatorial approaches with e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/wrr.12722DOI Listing

Recombinant Human C1 Esterase Inhibitor Treatment for Hereditary Angioedema Attacks in Children.

Pediatr Allergy Immunol 2019 Apr 16. Epub 2019 Apr 16.

Charité Universitätsmedizin Berlin, Berlin, Germany.

Background: Attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) usually begin during childhood or adolescence. However, limited data are available regarding indications and modalities of treatment of children. This study evaluated recombinant human C1-INH (rhC1-INH) for HAE attacks in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13065DOI Listing

NFκB- and MAP-Kinase Signaling Contribute to the Activation of Murine Myeloid Dendritic Cells by a Flagellin A:Allergen Fusion Protein.

Cells 2019 Apr 15;8(4). Epub 2019 Apr 15.

Paul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany.

Fusion proteins incorporating the TLR5-ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. We recently reported a flagellin:allergen fusion protein containing the TLR5-ligand flagellin A (FlaA) from and the major birch pollen allergen Bet v 1 (rFlaA:Betv1) to prevent allergic sensitization in an experimental mouse model. This study analyzes the signaling pathways contributing to rFlaA:Betv1-mediated pro- and anti-inflammatory cytokine secretion and cell metabolism in myeloid dendritic cells (mDCs) in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8040355DOI Listing

The SILVER Study. Efficacy Of Topical Nitric-Zinc Complex Solution In The Treatment Of Resistant Warts: A Post-Marketing Evaluation.

Dermatol Ther 2019 Apr 16:e12940. Epub 2019 Apr 16.

Department of Dermatology, Venereology and Allergology, Academic Teaching Department of Medical University Innsbruck, Central Hospital Bolzano/Bozen, Bolzano, Italy.

Background: The treatment of cutaneous viral warts caused by human papillomavirus (HPV) infection is often subject to local recurrence and a long clinical and treatment course. Our aim was to analyze real-life data on the treatment of difficult-to-treat warts from a multicenter post-marketing surveillance assessment on the efficacy, tolerability and safety of a commercially available nitric-zinc complex solution (NZCS).

Methods: Dermatologists from 14 Italian centers completed a questionnaire about their clinical experience on treatment of "difficult-to-treat" warts, which included plantar, periungual, anogenital wartsand warts on aesthetically sensitive areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12940DOI Listing

Anti-IL-10 antibody in systemic lupus erythematosus.

Open Access Rheumatol 2019 26;11:61-65. Epub 2019 Mar 26.

Division of Rheumatology and Allergology, St. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan,

Purpose: IL-10 is a cytokine known to inhibit inflammatory cytokines. To determine its role in the pathogenesis of systemic lupus erythematosus (SLE), the presence of anti-IL-10 antibody is required to be examined. Although antibodies against cytokines are known to be present in SLE, no studies have determined the role of IL-10, particularly in Japanese patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OARRR.S191953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440452PMC

Modelling of Protein Kinase Signaling Pathways in Melanoma and Other Cancers.

Cancers (Basel) 2019 Apr 3;11(4). Epub 2019 Apr 3.

Laboratory of Systems Tumor Immunology, Department of Dermatology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Hartmannstr. 14, 91052 Erlangen, Germany.

Melanoma is a highly aggressive tumor with a strong dependence on intracellular signaling pathways. Almost half of all melanomas are driven by mutations in the v-Raf murine sarcoma viral oncogene homolog B () with V600E being the most prevalent mutation. Recently developed targeted treatment directed against mutant BRAF and downstream mitogen-activated protein kinase (MAPK) MAP2K1 (also termed MEK1) have improved overall survival of melanoma patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers11040465DOI Listing

Combined culture and metagenomic analyses reveal significant shifts in the composition of the cutaneous microbiome in psoriasis.

Br J Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The treatment of psoriasis has been revolutionised by the development of biologic therapies. However, the pathogenesis of psoriasis, in particular the role of the cutaneous microbiome, remains incompletely understood. Moreover, skin microbiome studies have heavily relied on 16S rRNA sequencing data in the absence of bacterial culture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.17989DOI Listing
April 2019
1 Read

The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro.

Evid Based Complement Alternat Med 2019 11;2019:6374940. Epub 2019 Mar 11.

Department of Urology, Goethe-University, Frankfurt am Main, Germany.

The natural compound curcumin exerts antitumor properties in vitro, but its clinical application is limited due to low bioavailability. Light exposure in skin and skin cancer cells has been shown to improve curcumin bioavailability; thus, the object of this investigation was to determine whether light exposure might also enhance curcumin efficacy in bladder cancer cell lines. RT112, UMUC3, and TCCSUP cells were preincubated with low curcumin concentrations (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/6374940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432698PMC

Targeting of Basophil and Mast Cell Pro-Allergic Reactivity Using Functionalised Gold Nanoparticles.

Front Pharmacol 2019 29;10:333. Epub 2019 Mar 29.

Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham Maritime, United Kingdom.

Calcineurin inhibitors potentially prevent pro-allergic mediator release from basophils and mast cells but are rarely used systemically due to ubiquitous expressions of target signaling proteins. However, specific targeting of allergic effector cells with these inhibitors could circumvent unwanted side effects. We recently demonstrated the biocompatibility of gold nanoparticles (AuNPs) as a platform for non-toxic delivery of signaling inhibitors due to unique physicochemical properties of these nanomaterials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449467PMC

IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

Clin Mol Allergy 2019 2;17. Epub 2019 Apr 2.

Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12948-019-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444864PMC

Assessment of Melanogenesis in a Pigmented Human Tissue-Cultured Skin Equivalent.

Indian J Dermatol 2019 Mar-Apr;64(2):85-89

Department of Dermatology, Venereology, and Allergology, Goethe University Hospital, Frankfurt/Main, Germany.

Background: Organotypic tissue-cultured skin equivalents are used for a broad range of applications either as possible substitute for animal tests or for transplantation in patient-centered care.

Aims: In this study, we implemented melanocytes in a tissue-cultured full-thickness skin equivalent, consisting of epidermis and dermis. The versatility of this skin-like model with respect to pigmentation and morphological criteria was tested. Read More

View Article

Download full-text PDF

Source
http://www.e-ijd.org/text.asp?2019/64/2/85/254158
Publisher Site
http://dx.doi.org/10.4103/ijd.IJD_410_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440179PMC
April 2019
5 Reads

Frequency of allergic sensitization to Can f 5 in North East Italy. An analysis of 1403 ISACs 112 (Component Resolved Diagnosis) collected retrospectively.

Eur Ann Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Postgraduate School of Respiratory Medicine. Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.

Summary: Recent studies have shown the increasing relevance of allergic sensitization to Can f 5, a prostatic kallicrein expressed in the prostate and detectable only in male dogs. The aim of the present study was to establish the frequency, level of sensitization and association with other dog allergens of Can f 5, as assessed by Component Resolved Diagnosis (CRD- ISAC 112, ThermoFisher Scientific, Uppsala, Sweden), in North East Italy. A total of 1403 CRD ISAC 112 were examined retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23822/EurAnnACI.1764-1489.89DOI Listing

Migraine is not the most common comorbidity in hidradenitis suppurativa patients.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finland.

Migraine is the most common primary headache syndrome worldwide, affecting approximately 12% of the Caucasian population [1]. Migraine has been associated with various cardiovascular [2] and psychiatric co-morbidities [3], more recently inflammatory disorders such as psoriasis [4] and inflammatory bowel disease [5]. As hidradenitis suppurativa (HS) shares common comorbidity risks, we sought to investigate the possible link between migraine and HS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15625DOI Listing

Effective noninvasive body contouring by using a combination of cryolipolysis, injection lipolysis, and shock waves.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Weill Cornell Medical College, New York, New York.

Background: Cryolipolysis combined with shockwave therapy has been previously shown to have synergistic effects in body contouring results.

Objective: This open-label, prospective, multicenter, comparative study investigated the safety and efficacy of combined cryolipolysis, shockwave therapy with cryolipolysis, shockwave therapy, and injection polyenylphosphatidylcholine-based lipolysis.

Methods: Enrolled patients were treated in the abdominal or flank area with cryolipolysis, shockwave therapy and injection lipolysis (n = 10) or cryolipolysis and shockwave therapy (n = 4). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12953DOI Listing

Cystic fibrosis dyslipidaemia: A cross-sectional study.

J Cyst Fibros 2019 Apr 9. Epub 2019 Apr 9.

Poznan University of Medical Sciences, Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan, Poland. Electronic address:

Background: The interest in cystic fibrosis (CF) dyslipidaemia as a potential risk factor for cardiovascular disease is increasing with patients' survival. This study aimed to investigate CF dyslipidaemia, its clinical correlates and links to oxidized low-density lipoprotein (oxLDL), adiponectin, and apolipoprotein E (APOE).

Methods: This cross-sectional study assessed clinical characteristics of CF, as well as the serum lipid profile, oxLDL, adiponectin, and APOE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcf.2019.04.001DOI Listing

Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.

Acta Biochim Pol 2019 Apr 12. Epub 2019 Apr 12.

Department of Pulmonology and Allergology, Medical University of Lodz, Łódź, Poland.

Backgrounds: Deiodinase type 2 (DIO2) is a selenoenzyme involved in the synthesis of thyroid hormones. Chemerin is a newly investigated adipokine known also as novel chemokine. Both molecules have been recently expected and found to play an important role in inflammation and immunity. Read More

View Article

Download full-text PDF

Source
https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2761
Publisher Site
http://dx.doi.org/10.18388/abp.2018_2761DOI Listing
April 2019
2 Reads

Calculated arterial blood gas values from a venous sample and pulse oximetry: Clinical validation.

PLoS One 2019 12;14(4):e0215413. Epub 2019 Apr 12.

Department of Clinical Chemistry, Blekinge Hospital, Karlskrona, Sweden.

Background: Arterial blood gases (ABG) are essential for assessment of patients with severe illness, but sampling is difficult in some settings and more painful than for peripheral venous blood gas (VBG). Venous to Arterial Conversion (v-TAC; OBIMedical ApS, Denmark) is a method to calculate ABG values from a VBG and pulse oximetry (SpO2). The aim was to validate v-TAC against ABG for measuring pH, carbon dioxide (pCO2) and oxygenation (pO2). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215413PLOS

A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice.

Sci Rep 2019 Apr 11;9(1):5919. Epub 2019 Apr 11.

Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625, Hannover, Germany.

Neonatal animal models are increasingly employed in order to unravel age-specific disease mechanisms. Appropriate tools objectifying the clinical condition of murine neonates are lacking. In this study, we tested a scoring system specifically designed for newborn mice that relies on clinical observation and examination. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-42414-4
Publisher Site
http://dx.doi.org/10.1038/s41598-019-42414-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459866PMC
April 2019
2 Reads

Re-evaluation of polihexanide use in wound antisepsis in order to clarify ambiguities of two animal studies.

J Wound Care 2019 Apr;28(4):246-255

Consultant Clinical Microbiology and Infection Control, Consultant Infectious Diseases and Tropical Medicine, Department for Hospital Epidemiology and Infection Control, Medical University of Vienna, Austria.

Objective: Due to classification of the agent polihexanide (PHMB) in category 2 'may cause cancer' by the Committee for Risk Assessment of the European Chemicals Agency in 2011, the users of wound antiseptics may be highly confused. In 2017, this statement was updated, defining PHMB up to 0.1% as a preservative safe in all cosmetic products. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/jowc.2019.28.4.246DOI Listing
April 2019
5 Reads

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus.

J Invest Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2019.02.035DOI Listing
April 2019
1 Read

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15615DOI Listing
April 2019
2 Reads

Lung Eosinophils - a Novel 'Virus Sink' that is Defective in Asthma?

Allergy 2019 Apr 10. Epub 2019 Apr 10.

Child Life and Health and Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Eosinophils represent one of the most studied cells in the development and pathophysiology of various immune mediated disorders and conditions. Moreover, they serve as important biomarkers (diagnostic, therapy-driving, prognostic) in daily allergy praxis and can be affected by several therapeutic interventions. Eosinophils differentiate from a pluripotent progenitor under the influence of several cytokines and growth factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13811DOI Listing
April 2019
5 Reads

Oncolytic virotherapy enhances the efficacy of a cancer vaccine by modulating the tumor microenvironment.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Division of Virology, Medical University of Innsbruck, Austria.

The efficacy of cancer vaccines has been limited by the immunosuppressive tumor microenvironment, which can be alleviated by immune checkpoint inhibitor (ICI) therapy. Here, we tested if oncolytic viruses, similar to ICI, can also synergize with cancer vaccines by modulating the tumor microenvironment. VSV-GP, a chimeric vesicular stomatitis virus (VSV) pseudotyped with the glycoprotein of the lymphocytic choriomeningitis virus, is a promising new oncolytic virus candidate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32325DOI Listing
April 2019
1 Read

Clinical response of psoriasis to subcutaneous methotrexate correlates with inhibition of cutaneous Th1- and Th17-inflammatory pathways.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Dermatological Sciences, University of Manchester, Manchester, UK.

Methotrexate (MTX) is one of the most frequently used conventional systemic therapies for the treatment of moderate to severe plaque-type psoriasis. Although it has been available since the 1950s (1), its exact mechanism of action in the treatment of chronic inflammatory skin conditions remains to be fully determined. Clinical studies indicate good clinical responses (Psoriasis Area and Severity Index, PASI 75) in approximately 40% of patients with psoriasis and clinical effects peak after approximately 16 weeks of therapy (2, 3, 4). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.18001DOI Listing
April 2019
1 Read

Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma.

Virchows Arch 2019 Apr 10. Epub 2019 Apr 10.

Department of Urology and Paediatric Urology, Saarland University, Kirrberger Straße 100, 66424, Homburg, Germany.

The evidence concerning prognostic parameters for clinical decision-making in penile cancer is either weak or missing. We therefore analysed the prognostic value of the revised TNM and WHO classification systems on relapse and survival with special emphasis on HPV status. We collected clinical data and tissue samples of 121 patients from centres in Germany and Russia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-019-02566-0DOI Listing

Interrater and intrarater agreement and reliability in clinical staging of hidradenitis suppurativa/acne inversa.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

European Hidradenitis Suppurativa Foundation e.V, Dessau, Germany.

Core outcome domains represent a major need in hidradenitis suppurativa/acne inversa (HS) as reliable disease classification systems and treatment outcome parameters. Thorlacius et al. reported recently that none of the HS classifications systems could be recommended when used with HS experts as raters without a preceding bedside training session. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17982
Publisher Site
http://dx.doi.org/10.1111/bjd.17982DOI Listing
April 2019
2 Reads

Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843381

1 Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic.

Common variable immunodeficiency disorders (CVIDs) represent a group of primary immunodeficiency diseases characterized by hypogammaglobulinemia and dysfunctional immune response to invading pathogens. Previous studies have indicated that CVID is associated with microbial translocation and systemic myeloid cell activation. The goal of this study was to determine whether patients with CVID display elevated systemic levels of markers of granulocyte activation and whether the levels are further influenced by intravenous immunoglobulin (IVIg) infusions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2058738419843381DOI Listing
April 2019
1 Read

Successful treatment of psoriatic crumbly nails with ustekinumab.

Dermatol Ther 2019 Apr 9:e12914. Epub 2019 Apr 9.

Dermatology Unit, University of Rome "Tor Vergata", Rome, Italy.

Nail involvement can place a significant burden on patients as a result of functional damage and psychosocial problems, leading to major repercussions on the quality of life. There is strong evidence that nail psoriasis can often be difficult to treat. We report a a 69 year-old-man with severe onychodystrophy, onycholysis, and pain in the hands; he had been previously treated with topical and systemic traditional therapies without satisfactory response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12914DOI Listing

Tolerability and Efficacy of a Medical Device Repairing Emollient Cream in Children and Adults with Mild to Moderate Atopic Dermatitis.

Dermatol Ther (Heidelb) 2019 Apr 9. Epub 2019 Apr 9.

Clinical Skin Research and Development Center, Hôtel Dieu, Pierre Fabre Dermo-Cosmétique, Toulouse, France.

Introduction: Regular emollient application is recommended for managing atopic dermatitis (AD). Although many emollients are available, only AD-tested medical device repairing emollient creams (MDRECs) can be recommended for treating and preventing AD skin lesions. Here, we evaluated the tolerability and benefit of a new MDREC in an open-label study in infants, young children, and adults with mild to moderate AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13555-019-0295-0DOI Listing

Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics.

Sci Rep 2019 Apr 9;9(1):5823. Epub 2019 Apr 9.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Brown and beige adipocytes are enriched in mitochondria with uncoupling protein-1 (UCP1) to generate heat instead of ATP contributing to healthy energy balance. There are few human cellular models to reveal regulatory networks in adipocyte browning and key targets for enhancing thermogenesis in obesity. The Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte line has been a useful tool to study human adipocyte biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42256-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456729PMC
April 2019
1 Read

Treatment of recalcitrant squamous carcinoma in situ of penis with tapering imiquimod 5%-3,75% cream.

Dermatol Ther 2019 Apr 9:e12904. Epub 2019 Apr 9.

Dermatology Department, Department of Systems Medicine, University of Rome Tor Vergata, Viale Oxford, Rome, Italy.

Background: The efficacy of imiquimod as treatment of genital squamous carcinoma (SCC) is known and described in literature.

Objective: Evaluate the efficacy of tapering doses of imiquimod 5%-3,75% cream in the treatment of recalcitrant penis SCC in situ.

Methods: A patient with a SCC in situ received three cycles of therapy with imiquimod cream. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12904DOI Listing

An EAACI position paper on the investigation of perioperative immediate hypersensitivity reactions.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Allergy Unit, Department of Dermatology, University Hospital, University of Basel, Basel, Switzerland.

Perioperative immediate hypersensitivity reactions are rare. Subsequent allergy investigation is complicated by multiple simultaneous drug exposures, the use of drugs with potent effects and the many differential diagnoses to hypersensitivity in the perioperative setting. The approach to the investigation of these complex reactions is not standardized and it is becoming increasingly apparent that collaboration between experts in the field of allergy/immunology/dermatology and anaesthesiology is needed to provide the best possible care for these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13820DOI Listing
April 2019
1 Read

Legends of allergology: Dietrich Kraft.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.

The term allergy was coined in 1906 by the Austrian scientist and paediatrician Clemens Freiherr von Pirquet, head of the Department of Paediatrics in Vienna from 1912 to 1929. His successor, Franz Hamburger, obliterated all references to Pirquet, especially the term allergy, creating a large gap in allergy research until the 1960s. The University of Vienna Dermatology and ENT departments performed skin prick tests and hyposensitizations well into the late 1970s, but no basic scientific research was done. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13816
Publisher Site
http://dx.doi.org/10.1111/all.13816DOI Listing
April 2019
5 Reads

Legends of Allergy: Stephen J. Galli.

Allergy 2019 Apr 9. Epub 2019 Apr 9.

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA.

Professor Stephen J. Galli's rigorous and innovative research in the field of allergy and immunology has truly made him a legend in the field. His accomplishments are many as are the awards and recognitions he has received. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13815DOI Listing

Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis.

Int J Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.

Background: Changing the resources of vitamin D and antioxidant nutrients may affect the course of allergic diseases. The aim of the study was to investigate the association between CoQ10, vitamin D, retinol, and α-tocopherol serum levels and severity of atopic dermatitis (AD) in children.

Methods: Twenty-nine children with AD aged from 1 to 15 years were enrolled into the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14438DOI Listing

Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer.

J Eur Acad Dermatol Venereol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information about the impact of SC on QoL. Generic, dermatology-specific, cancer-specific, SC-specific, facial SC-specific, NMSC-specific, basal cell carcinoma-specific and melanoma-specific QoL questionnaires have been used to assess HRQoL in SC patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.15487DOI Listing
April 2019
1 Read

Correction to: The Burden of Sarcoidosis Symptoms from a Patient Perspective.

Lung 2019 Apr 8. Epub 2019 Apr 8.

ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, PO Box 2400, 3430 VB, Nieuwegein, The Netherlands.

The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name "M.D. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00408-019-00221-8
Publisher Site
http://dx.doi.org/10.1007/s00408-019-00221-8DOI Listing
April 2019
5 Reads

The REal Life EVidence AssessmeNt Tool (RELEVANT): development of a novel quality assurance asset to rate observational comparative effectiveness research studies.

Clin Transl Allergy 2019 27;9:21. Epub 2019 Mar 27.

16Hôpital Cochin (APHP), University Paris Descartes (EA2511), Paris, France.

Background: Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies represent an important complementary evidence source answering different research questions and are particularly valuable in guiding clinical decision making in real-life patient and practice settings. Tools are required to assist in quality appraisal of observational CER to enable identification of and confidence in high-quality CER evidence to inform guideline development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13601-019-0256-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436213PMC
March 2019
3 Reads

Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group-European Academy of Allergy and Clinical Immunology Task Force.

Clin Transl Allergy 2019 27;9:20. Epub 2019 Mar 27.

13Observational and Pragmatic Research Institute, 60 Paya Lebar Road, Paya Lebar Square, #05-33/34, Singapore, 409051 Singapore.

Introduction: A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observational research to identify high-quality real-life asthma studies that could be considered within future guideline development.

Methods: The resulting REal Life EVidence AssessmeNt Tool (RELEVANT) was achieved through an extensive analysis of existing initiatives in this area. The first version was piloted among 9 raters across 6 articles; the revised, interim, version underwent extensive testing by 22 reviewers from the EAACI membership and REG collaborator group, leading to further revisions and tool finalisation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13601-019-0255-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436229PMC

Advanced Ulcerated Squamous Cell Carcinoma of the Hand with Locoregional Axillary Lymph Node Metastasis - Case Report and Literature Review.

Open Access Maced J Med Sci 2019 Mar 14;7(5):791-793. Epub 2019 Mar 14.

Center for Physical and Rehabilitative Medicine, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Cutaneous squamous cell carcinoma (SCC) of the hand is the most common soft-tissue malignancy in this particular region. A literature survey suggested a higher rate of metastases in advanced SCC of the hand compared to head-and-neck cutaneous SCC.

Case Report: An 84-year-old man presented with an ulcerated firm tumour on the dorsum of his right hand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2019.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447345PMC
March 2019
1 Read

Amplifying the concept of psoriatic arthritis: The role of autoimmunity in systemic psoriatic disease.

Autoimmun Rev 2019 Apr 5. Epub 2019 Apr 5.

Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that may be present in near 30% of patients affected by psoriasis (PsO), clinically characterized by inflammation of periarticular (e.g., enthesis) and articular structures. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15689972193008
Publisher Site
http://dx.doi.org/10.1016/j.autrev.2018.11.007DOI Listing
April 2019
3 Reads

Pathophysiology of atopic dermatitis.

J Dtsch Dermatol Ges 2019 Apr;17(4):433-440

Department of Dermatology and Allergology, Christine Kühne Center for Allergy Research and Education, Universität of Bonn, Bonn, Germany.

Only few diseases have been studied as extensively and on as many different levels in recent years as atopic dermatitis (AD). One of the reasons why AD is the focus of interest is that it is one of the most common chronic inflammatory skin diseases, affecting up to 30 % of children and 1-10 % of adults. Numerous complex alterations both on the genetic level as well as on the level of innate and adaptive immunity have been identified and form the basis for the characterization of different patient groups and the development of novel diagnostic and therapeutic approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.13819DOI Listing
April 2019
1 Read

Impact of maternal education on the outcome of newborns requiring surgery for congenital malformations.

PLoS One 2019 8;14(4):e0214967. Epub 2019 Apr 8.

Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.

Objective: Numerous studies established a link between socioeconomic status (SES) and several dimensions of general health. This study examines the association between maternal education as a widely used indicator of SES and outcome in newborns requiring surgical correction of congenital anomalies.

Methods: Ambispective data analysis of newborns with esophageal atresia (EA), intestinal atresia (IA), congenital diaphragmatic hernia (CDH), omphalocele (OC), gastroschisis (GS) undergoing surgery between 01/2008-11/2017 accessing the clinical databases Neodat and Viewpoint. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214967PLOS

A reoccurring drug induced liver injury (DILI) with cetirizine and amoxicillin-clavulanate potassium.

J Investig Allergol Clin Immunol 2019 Apr 8. Epub 2019 Apr 8.

Allergology-Internal Medicine, Hospital Universitari Bellvitge - IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18176/jiaci.0397DOI Listing

Relating Experienced To Recalled breathlessness Observational (RETRO) study: a prospective study using a mobile phone application.

BMJ Open Respir Res 2019 12;6(1):e000370. Epub 2019 Feb 12.

Department of Clinical Sciences, Division of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.

Background: Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjresp-2018-000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424247PMC
February 2019

2019 ARIA Care pathways for allergen immunotherapy.

Allergy 2019 Apr 7. Epub 2019 Apr 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Uniersität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy-Centre, Department of Dermatology and Allergy, member of GA2LEN, Berlin, Germany.

Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides simple recommendations that can be used by all stakeholders including health professionals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.13805DOI Listing
April 2019
4 Reads

Regulation of sirtuin expression in autoimmune neuroinflammation: Induction of SIRT1 in oligodendrocyte progenitor cells.

Neurosci Lett 2019 Apr 4;704:116-125. Epub 2019 Apr 4.

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany. Electronic address:

In multiple sclerosis (MS) regeneration of oligodendrocytes following inflammatory demyelination is limited by the compromised ability of progenitors to repopulate lesioned areas and transition to functionally competent oligodendrocytes. Regarding underlying mechanisms, the involvement of epigenetic processes has been suggested, e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2019.04.007DOI Listing
April 2019
1 Read