16,285 results match your criteria Allergology international: official journal of the Japanese Society of Allergology[Journal]


Tachykinin Antagonists Reverse Ischemia/Reperfusion Gastrointestinal Motility Impairment in Rats.

J Surg Res 2020 Jul 3;255:510-516. Epub 2020 Jul 3.

Department of Pharmacology, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Background: Supraceliac aortic clamping and unclamping produces ischemia-reperfusion (I/R) injury of the splanchnic organs. The protective effects of tachykinin receptor antagonists, SR140333 (NK receptor), SR48968 (NK receptor), and SB222200 (NK receptor), against I/R-induced inhibition of intestinal motility were tested in rats.

Material And Methods: The intestinal transit of Evans blue was measured in untreated rats and animals subjected to skin incision, I/R (1 h superior mesenteric artery occlusion followed by 24 h reperfusion) or sham operation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2020.05.092DOI Listing

Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on PCR and serology testing.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Dermatology Department, University Hospital Bordeaux, Bordeaux, France.

Introduction: Acral lesions, mainly chilblains, are the most frequently reported cutaneous lesions associated with COVID-19. In more than 80% of tested patients, nasopharyngeal swabs were negative on RT-PCR for SARS-CoV-2 when performed, and serology was generally not performed.

Materials And Methods: A national survey was launched on March 30, 2020 by the French society of dermatology asking physicians to report cases of skin manifestations in patients with suspected or confirmed COVID-19 by using a standardized questionnaire. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.19377DOI Listing

RNA-seq based profiling of extracellular vesicles in plasma reveals a potential role of miR-122-5p in asthma.

Allergy 2020 Jul 5. Epub 2020 Jul 5.

Research Center Borstel, Leibniz Lung Center, Member of the German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.

Asthma is a heterogeneous disease encompassing several distinct sub-phenotypes with different aetiologies and treatment responses, but we are lacking markers to differentiate patient subgroups. MicroRNAs (miRNA) can regulate gene expression post-transcriptionally. Due to their high stability in body fluids, their easy detection, and their functional relevance in asthma, we and others have proposed extracellular miRNAs in non-invasive clinical samples as biomarkers for asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14486DOI Listing

Neurological manifestation of immune system dysregulation resulting from CTLA-4 receptor mutation: a case report.

Mult Scler Relat Disord 2020 Jun 21;45:102313. Epub 2020 Jun 21.

Faculty of Medicine, Masaryk University Brno, Czech Republic; Department of Neurology, University Hospital Brno, Czech Republic. Electronic address:

This contribution reports the case of a young female patient with a cytotoxic T-lymphocyte antigen 4 (CTLA-4) heterozygous missense mutation giving rise to a broad range of autoimmune diseases, including central nervous system inflammation presenting as disseminated intramedullary and infiltrating brain lesions on MRI. Multiple sclerosis was one of the diagnoses considered. CTLA-4 is a negative immune regulator essential for the function of regulatory T-cells, themselves responsible for maintaining self-tolerance and immune homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2020.102313DOI Listing

FeNO Response to Oral Corticosteroids in Children with Mild to Moderate Asthma: Influence of Race.

Ann Allergy Asthma Immunol 2020 Jul 1. Epub 2020 Jul 1.

Allergy and Immunology Department, Children's Hospital Colorado, Aurora, Colorado; National Jewish Health, Denver, Colorado.

Background: Fraction exhaled nitric oxide (FeNO) is a non-invasive biomarker of type-2 asthma that can predict response to inhaled corticosteroid(ICS) therapy. Little is known regarding the magnitude of FeNO reduction following an oral corticosteroid(OCS) course and less is known whether there are differential responses based on race in children with mild-to-moderate asthma.

Objective: To assess the effect of a short course of OCS on FeNO in asthmatic children and to determine if the effect is influenced by race. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2020.06.036DOI Listing

Nivolumab - associated pemphigoid - like blistering dermatosis after sun exposure.

Dermatol Ther 2020 Jul 4:e13970. Epub 2020 Jul 4.

Department of Dermatology, Allergology and Venereology, Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13970DOI Listing

A Clinical Case of Weak A Antigen on the Erythrocytes in a Person with Coexistent Anti-A Antibodies.

Arch Razi Inst 2020 Jun 1;75(2):257-265. Epub 2020 Jun 1.

Kharkiv National Medical University, Department of Internal Medicine № 2, Clinical Immunology and Allergology Named after Academician L.T. Malaya.

This study investigated a person with an AB0 discrepancy. Her blood group initially typed at the birth as AB Rh+ (positive); however, it was B Rh+ (positive) or Rh- (negative) when she was in her teens. At room temperature, her erythrocytes were agglutinated by anti-B, and the agglutination was significantly weaker at 37 ºC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22092/ari.2020.341761.1439DOI Listing

Reply to "Does sugammadex have multiple mechanisms for causing anaphylaxis?"

J Allergy Clin Immunol Pract 2020 Jul - Aug;8(7):2458-2459

Faculty of Medicine and Health Science, Department of Immunology - Allergology - Rheumatology and the Infla-Med Consortium of Excellence, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium; Department of Immunology - Allergology, AZ Jan Palfijn Gent, Ghent, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2020.04.050DOI Listing

Asthmatic patients in COVID-19 outbreak: Few cases despite many cases.

J Allergy Clin Immunol 2020 Jun 22. Epub 2020 Jun 22.

Department of Medicine, Section of Internal Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy; Department of Medicine, Respiratory Medicine Unit, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2020.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306702PMC

Application of specific-to-total IgE ratio does not benefit diagnostic performance of serologic testing for rocuronium allergy.

Br J Anaesth 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and Infla-Med Centre of Excellence, Antwerp, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.032DOI Listing

Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca mobilization and cytotoxicity in human NK cells.

J Leukoc Biol 2020 Jul 3. Epub 2020 Jul 3.

Division of Immunology and Allergology, Department of Medicine, University Hospitals and Medical Faculty, Geneva, Switzerland.

NK cell-mediated Ab-dependent cellular cytotoxicity (ADCC) is increasingly recognized to play an important role in cancer immunotherapy, transplant rejection, and autoimmunity. However, several aspects of the molecular interactions of IgG subclasses with the Fc-gamma receptor IIIA (FcγRIIIA)/CD16a expressed on NK cells remain unknown. The aim of the current study was to further analyze the role of IgG subclasses and FCGR3A V158F single nucleotide polymorphism (SNP) on Ca signaling and NK cell-mediated ADCC against Daudi target cells in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.5MA0620-039RDOI Listing

Atypical Fibroxanthoma - An Analysis of 105 Tumors.

Dermatol Ther 2020 Jul 3:e13962. Epub 2020 Jul 3.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Atypical fibroxanthoma (AFX) is a rare, low-grade dermal sarcoma.

Patients And Methods: We analyzed our files from January 2001 to January 2020 for AFX. Clinical parameters, histopathology, treatment and outcome have been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13962DOI Listing

Validity of EQ-5D-5L, Skindex-16, DLQI and DLQI-R in patients with hidradenitis suppurativa.

J Eur Acad Dermatol Venereol 2020 Jul 2. Epub 2020 Jul 2.

Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary.

Background: Numerous generic, skin- and disease-specific health-related quality of life (HRQoL) measures are available for patients with hidradenitis suppurativa (HS). Yet, robust psychometric evidence is lacking in many aspects of these outcome measures.

Objectives: We sought to determine convergent and known-groups validity of multiple generic and skin-specific HRQoL measures and to identify predictors of impaired HRQoL in patients with HS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16642DOI Listing

Cryobiopsy in the diagnosis of bronchiolitis: a retrospective analysis of twenty-three consecutive patients.

Sci Rep 2020 Jul 2;10(1):10906. Epub 2020 Jul 2.

Department of Diseases of the Thorax, G.B. Morgagni Hospital, Forlì, Italy.

Bronchiolitis manifests as a variety of histological features that explain the complex clinical profiles and imaging aspects. In the period between January 2011 and June 2015, patients with a cryobiopsy diagnosis of bronchiolitis were retrospectively retrieved from the database of our institution. Clinical profiles, imaging features and histologic diagnoses were analysed to identify the role of cryobiopsy in the diagnostic process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67938-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331727PMC

High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice.

Respir Res 2020 Jul 2;21(1):168. Epub 2020 Jul 2.

Department of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.

Background: Titanium dioxide nanoparticles (TiO NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO powder are more susceptible to the risks of developing respiratory diseases. Accordingly, this issue has increasingly attracted the researchers' interest in understanding the consequences of TiO NPs exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-020-01386-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331175PMC

The risk of fracture and prevalence of osteoporosis is elevated in patients with idiopathic inflammatory myopathies: cross-sectional study from a single Hungarian center.

BMC Musculoskelet Disord 2020 Jul 2;21(1):426. Epub 2020 Jul 2.

Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Móricz Zsigmond út 22, Debrecen, H-4032, Hungary.

Background: The prevalence of osteoporosis and risk of fractures is elevated in rheumatoid arthritis (RA), but we have limited information about the bone mineral density (BMD) and fracture risk in patients with inflammatory myopathies. We intended to ascertain and compare fracture risk, bone mineral density and the prevalence of vertebral fractures in patients with inflammatory myositis and rheumatoid arthritis and to assess the effect of prevalent fractures on the quality of life and functional capacity.

Methods: Fifty-two patients with myositis and 43 patients with rheumatoid arthritis were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12891-020-03448-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333418PMC

Atopic dermatitis displays stable and dynamic skin transcriptome signatures.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Venereology, and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: Skin transcriptome studies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under therapy. These observations were mainly made in trials and based on microarray data.

Objectives: To explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2020.06.012DOI Listing

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.

Mol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University Salzburg, Salzburg, Austria.

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1878-0261.12758DOI Listing

Nasal IgE in subjects with allergic and non-allergic rhinitis.

World Allergy Organ J 2020 Jun 23;13(6):100129. Epub 2020 Jun 23.

Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt, Germany.

Purpose: The prevalence of "ocal allergic rhinitis" within individuals suffering from perennial rhinitis remains uncertain, and patients usually are diagnosed with non-allergic rhinitis. The aim of this study was to evaluate the prevalence of a potential "local allergic rhinitis" in subjects suffering from non-allergic rhinitis in a non-selected group of young students.

Methods: 131 students (age 25. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.waojou.2020.100129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322186PMC

Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing).

Pharmaceuticals (Basel) 2020 Jun 29;13(7). Epub 2020 Jun 29.

Bayer Consumer Care AG, Peter Merian-Strasse 84, CH-4002 Basel, Switzerland.

With the availability of new technologies, the number of subjects undergoing medical and cosmetic interventions is increasing. Many procedures (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ph13070138DOI Listing

CPAnet Registry-An International Chronic Pulmonary Aspergillosis Registry.

J Fungi (Basel) 2020 Jun 29;6(3). Epub 2020 Jun 29.

Department of Respiratory Medicine, Ghent University Hospital, B-9000 Ghent, Belgium.

Chronic pulmonary aspergillosis (CPA) is a chronic fungal infection of the lung associated with high morbidity and mortality. The CPA Research network (CPAnet) registry established in 2018 is an international multicenter collaboration aiming to improve CPA knowledge and patient care. This study's aim was to describe the data collection process and content of CPAnet registry with preliminary clinical data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jof6030096DOI Listing

Emerging Therapeutic Options for Chronic Pruritus.

Am J Clin Dermatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 1 Chalubinskiego Street, 50-368, Wrocław, Poland.

Chronic pruritus, defined as an unpleasant sensation resulting in a need to scratch that lasts more than 6 weeks, is a prevalent and bothersome symptom associated with both cutaneous and systemic conditions. Due to complex pathogenesis and profuse contributing factors, chronic pruritus therapy remains challenging. Regardless of the well-established antipruritic properties of classic pharmacotherapy (topical therapy, phototherapy and systemic therapy), these methods often provide insufficient relief for affected individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40257-020-00534-yDOI Listing

Pneumocystis Jirovecii Pneumonia and SARS-CoV-2 Co-Infection in newly diagnosed HIV-1 infection.

Clin Infect Dis 2020 Jul 1. Epub 2020 Jul 1.

Department of Pneumology, Allergology and Critical Care Medicine, Saarland University, Homburg/Saar, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciaa906DOI Listing

Demyelinating polyneuropathy and lymphoplasmacytic lymphoma coexisting in 36-year-old man: A case report.

World J Clin Cases 2020 Jun;8(12):2566-2573

Department of Internal Medicine, Autoimmune and Metabolic Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice 40-752, Poland.

Background: Lymphoplasmacytic lymphoma is a rare non-Hodgkin's lymphoma, occurring mostly in the elderly. It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow, lymph nodes and spleen. It may also affect nerve roots and meninges; some patients develop sensorimotor polyneuropathy which may precede general symptoms of lymphoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v8.i12.2566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322434PMC

Decreased Risk of Ischemic Heart Disease in Individuals with Severe Alpha 1-Antitrypsin Deficiency (PiZZ) in Comparison with the General Population.

Int J Chron Obstruct Pulmon Dis 2020 4;15:1245-1252. Epub 2020 Jun 4.

Departments of Respiratory Medicine, Skåne University Hospital, Lund University, Lund, Sweden.

Background: Severe alpha-1-antitrypsin deficiency (AATD) is an established risk factor for chronic obstructive pulmonary disease (COPD) and liver disease, but the effect on the incidence of ischemic heart disease (IHD) is not well known. The aim was to evaluate the risk of incident IHD in patients with severe AATD compared with a random sample of the general population, with known smoking habits.

Methods: AAT-deficient individuals, phenotype PiZZ (n=1545), were included in the Swedish National AATD Register. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/COPD.S247377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282800PMC

Long-term efficacy of injected allergen immunotherapy for treatment of grass pollen allergy in elderly patients with allergic rhinitis.

Allergy Asthma Proc 2020 Jul;41(4):271-277

Humanitas Research Hospital, Milano, Italy.

The effect of prolonged allergen immunotherapy is still insufficiently known, especially in elderly patients. The effect after a 3-year course of injected allergen-specific immunotherapy (AIT) for grass pollen allergy in elderly patients with allergic rhinitis was observed. Thirty-eight elderly patients (mean ± standard deviation, 66. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2500/aap.2020.41.200035DOI Listing

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Nutrients 2020 06 26;12(6). Epub 2020 Jun 26.

School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, UK.

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu12061901DOI Listing

Binding of CML-Modified as Well as Heat-Glycated β-lactoglobulin to Receptors for AGEs Is Determined by Charge and Hydrophobicity.

Int J Mol Sci 2020 Jun 26;21(12). Epub 2020 Jun 26.

Food Quality & Design Group, Wageningen University & Research Centre, 6708 WG Wageningen, The Netherlands.

Intake of dietary advanced glycation end products (AGEs) is associated with inflammation-related health problems. Nε-carboxymethyl lysine (CML) is one of the best characterised AGEs in processed food. AGEs have been described as ligands for receptors present on antigen presenting cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21124567DOI Listing

Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results.

J Clin Med 2020 Jun 26;9(6). Epub 2020 Jun 26.

University Children's Hospital, Ruhr University, 44791 Bochum, Germany.

Cystic fibrosis (CF; OMIM 219700) is a rare genetic disorder caused by a chloride channel defect, resulting in lung disease, pancreas insufficiency and liver impairment. Altered L-arginine (Arg)/nitric oxide (NO) metabolism has been observed in CF patients' lungs and in connection with malnutrition. The aim of the present study was to investigate markers of the Arg/NO pathway in the plasma and urine of CF patients and to identify possible risk factors, especially associated with malnutrition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9062012DOI Listing

SARS-CoV-2 pneumonia in hospitalized asthmatic patients did not induce severe exacerbation.

J Allergy Clin Immunol Pract 2020 Jun 27. Epub 2020 Jun 27.

Chest diseases department, Strasbourg University Hospital, France; Public Health Department, Strasbourg University Hospital, France; EA 3070 Federation of Translational Medicine, FHU Homicare, University of Strasbourg, France. Electronic address:

Background: Viral infections are known to exacerbate asthma in adults. Previous studies have found few asthmatics among SARS-CoV-2 pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2020.06.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320869PMC

Age-of-onset information helps identify 76 genetic variants associated with allergic disease.

PLoS Genet 2020 Jun 30;16(6):e1008725. Epub 2020 Jun 30.

University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Pediatric Pulmonology and Pediatric Allergology, and University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.

Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1008725DOI Listing

The use of face masks during the COVID-19 pandemic in Poland: a survey study of 2315 young adults.

Dermatol Ther 2020 Jun 29:e13909. Epub 2020 Jun 29.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

Face masks wearing during the COVID-19 pandemic became ubiquitous. The aim of our study was to assess the use of face masks among young adults during the current viral pandemic. The survey was based on specially created Google Forms and posted on numerous Facebook groups for young people in Poland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.13909DOI Listing

Tinea manuum caused by Trichophyton erinacei.

J Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology and Allergology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.15477DOI Listing

Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET.

Sci Rep 2020 Jun 29;10(1):10544. Epub 2020 Jun 29.

Department of Internal Medicine V - Pulmonology, Allergology, Critical Care Care Medicine, Saarland University Hospital, Homburg, Germany.

We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off ≤2) and all-cause mortality over 3 years of follow-up were determined by logistic and Cox regression analyses, with sex, age, BMI and pack years as covariates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67197-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324620PMC

Cytological-energy analysis of pleural effusions with predominance of neutrophils.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620935772

Faculty of Medicine and University Hospital in Hradec Kralove, Department of Clinical Immunology and Allergology, Charles University in Prague, Hradec Kralove, Czech Republic.

Background: The predominance of neutrophils in pleural effusions of patients with different serious impairments of the pleural cavity organs is often found. The aim of this study was to identify the type of injury using the cytological-energy analysis of pleural effusions.

Methods: We analysed 635 samples of pleural effusions with predominance of neutrophils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753466620935772DOI Listing

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives.

J Vis Exp 2020 Jun 15(160). Epub 2020 Jun 15.

Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS); Department of Pharmacy, Saarland University;

fDrug research for the treatment of lung infections is progressing towards predictive in vitro models of high complexity. The multifaceted presence of bacteria in lung models can re-adapt epithelial arrangement, while immune cells coordinate an inflammatory response against the bacteria in the microenvironment. While in vivo models have been the choice for testing new anti-infectives in the context of cystic fibrosis, they still do not accurately mimic the in vivo conditions of such diseases in humans and the treatment outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/61069DOI Listing

Postoperative complications in dermatological patients undergoing microscopically controlled surgery in inpatient setting (next-day surgery): A single-center epidemiological study.

J Dtsch Dermatol Ges 2020 Jun 28. Epub 2020 Jun 28.

Department of Dermatology and Allergology, University Hospital of RWTH Aachen, Aachen, Germany.

Background: Surgical site infections (SSI), bleeding, and necrosis are possible complications of dermatological surgery, and their rates are well described for Mohs surgery (same-day surgery). However, there are only limited data on their occurrence in microscopically controlled surgery of the form in which it is practiced in German hospitals (next-day surgery).

Materials And Methods: We performed a retrospective analysis of patient records of patients hospitalized for microscopically controlled surgery during the year 2017 (12 months) in the Department of Dermatology and Allergology at the University Hospital of the RWTH Aachen (Aachen, Germany). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.14148DOI Listing

Isolated linear psoriasis: case report on an eight-year-old child.

J Dtsch Dermatol Ges 2020 Jun 28. Epub 2020 Jun 28.

Department of Dermatology, Phlebology and Allergology, Bad Cannstatt Hospital, Stuttgart Hospital, Stuttgart, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.14146DOI Listing

Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma.

Biomed Res Int 2020 10;2020:7196981. Epub 2020 Jun 10.

Animal Physiology, Biochemistry and Biostructure, Poznań University of Life Sciences, Poznań, Poland.

Methods: In the study, we included 86 children diagnosed with atopic asthma ( = 25), allergic rhinitis ( = 20), and atopic dermatitis ( = 20) and healthy control subjects ( = 21) of Caucasian origin from the Polish population. The blood leukocyte expression of 31 genes involved in neuroinflammatory response (neurotrophins, their receptors, neuropeptides, and histamine signaling pathway) was analysed using TaqMan low-density arrays. The relative expression of selected proteins from plasma was done using TaqMan Protein Assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/7196981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305544PMC

Different Development Forms of Local Allergic Rhinitis towards Birch.

Biomed Res Int 2020 4;2020:3408561. Epub 2020 Jun 4.

Clinical Department of Internal Medicine, Dermatology and Allergology, Medical University of Silesia, Katowice, Poland.

Background: Efficacy of allergen immunotherapy (AIT) in local allergic rhinitis (LAR) is a new subject of research. The presence of asthmatic symptoms in patients with LAR in the context of AIT is unexplored.

Objective: The efficacy and safety of AIT in patients with LAR towards birch pollen were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3408561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293726PMC

The risk of osteoporosis in patients with asthma.

Eur Clin Respir J 2020 19;7(1):1763612. Epub 2020 May 19.

Department of Medicine, Vejle Hospital, Vejle, Denmark.

It is well-known that use of continuous systemic corticosteroids (SG) affects bone metabolism, bone mineral density (BMD), and ultimately increases the risk of osteoporosis. In patients with asthma, on the other hand, the effects of long-term high-dose inhaled corticosteroids (ICS) on BMD and risk of osteoporotic fractures is controversial. The reasons for this inconsistency could be explained by the fact that only few long-term studies investigating the effect of ICS in patients with asthma exist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20018525.2020.1763612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301699PMC

Dupilumab-induced Serum Sickness Like Reaction: An Unusual Adverse Effect in a patient with atopic eczema.

J Eur Acad Dermatol Venereol 2020 Jun 27. Epub 2020 Jun 27.

Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

Dupilumab is a fully humanized Immunoglobulin-(Ig)-G4 antibody against the interleukin (IL)-4α subunit of the IL-4- and the IL-13-receptor. In patients with atopic eczema (AE), most frequent adverse reactions include injection site reactions and conjunctivitis/blepharitis. Recently, a case with suspicion of an IgE-mediated hypersensitivity was reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.16782DOI Listing

Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO).

Allergy 2020 Jun 27. Epub 2020 Jun 27.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Therapeutic advances using targeted biologicals and small molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and autoimmune diseases are successfully targeted, and current treatment options, besides allergen immunotherapy for selected allergic diseases, fail to change the disease course. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.14478DOI Listing

Technical validity and usability of a novel smartphone connected spirometry device for pediatric patients with asthma and cystic fibrosis.

Pediatr Pulmonol 2020 Jun 27. Epub 2020 Jun 27.

Juliana Children's Hospital, HAGA teaching Hospital, the Hague, the Netherlands.

Background: Diagnosis and follow-up of respiratory diseases traditionally rely on pulmonary function tests (PFT), which are currently performed in hospitals and require trained personnel. Smartphone connected spirometers, like the Air Next spirometer, have been developed to aid in the home-monitoring of patients with pulmonary disease. The aim of this study was to investigate the technical validity and usability of the Air Next spirometer in pediatric patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ppul.24932DOI Listing

Biological agents for severe asthma: the evolution of the at-home self-injection approach.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):421-427

Department of Internal Medicine, Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.

Purpose Of Review: New biological agents, in addition to the well-established omalizumab, have been nowadays introduced into clinical practice for severe asthma. This suggested the possibility of an at-home self-administration, as currently happening for other biological agents for immune-mediated diseases.

Recent Findings: In the very recent years, there were structured clinical trials investigating the self at home administrations of biologicals for severe asthma, showing with different principles, a possible advantage and convenience for the patient, and a socioeconomic saving. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000656DOI Listing

The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):367-373

Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose Of Review: Allergic skin diseases such as urticaria, atopic dermatitis and allergic contact dermatitis are among the most common skin diseases with severe socioeconomic consequences. The pathogenesis of allergic skin diseases is complex. This review provides an overview of cytocines IL-17, IL-23, IL-31 and IL-33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000658DOI Listing

Investigation of perioperative hypersensitivity reactions: an update.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):338-345

Department of Dermatology and Allergy, Danish Anaesthesia Allergy Centre, Allergy Clinic, Copenhagen University Hospital, Gentofte.

Purpose Of Review: The purpose of this review is to provide an update on how best to manage the investigation of suspected perioperative hypersensitivity reactions based on recent literature and key publications.

Recent Findings: In the past two years, several very important initiatives have been taken in the field of perioperative hypersensitivity. The 6th national audit project in the United Kingdom has provided new knowledge through a series of studies, including a nationwide prospective study, and the European Academy of Allergy and Clinical Immunology has commissioned a position paper with updated recommendations for investigations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000654DOI Listing