1,149 results match your criteria Allergology International[Journal]


Eosinophilic gastrointestinal diseases - Pathogenesis, diagnosis, and treatment.

Allergol Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Steel Memorial Hirohata Hospital, Himeji, Japan.

Eosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In development of EoE, refluxed gastric acid may also have an important role. For diagnosis of EGIDs, the presence of symptoms possibly originating from the involved gastrointestinal tract and dense eosinophil infiltration are important factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930193003
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http://dx.doi.org/10.1016/j.alit.2019.03.003DOI Listing
April 2019
1 Read

Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.

Allergol Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

The aim of this review was to provide an updated overview of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). Several new insights have been made, particularly with regards to the diagnosis, pathogenesis and care of some important complications and sequelae. The indication of herpesvirus reactivations in diagnosis in the assessment of disease severity is now better specified. Read More

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http://dx.doi.org/10.1016/j.alit.2019.03.006DOI Listing

Dual sublingual immunotherapy with Japanese Cedar Pollen droplets and House Dust Mite tablets.

Allergol Int 2019 Apr 5. Epub 2019 Apr 5.

Department of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medicine, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.03.005DOI Listing

Potential risk factors of adverse reactions to nonionic contrast media in patients with underlying dermatological diseases: An 8-year retrospective survey.

Allergol Int 2019 Apr 3. Epub 2019 Apr 3.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.03.004DOI Listing

A case of anaphylactic reaction to chamomile tea in a patient with mugwort pollinosis.

Allergol Int 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, Iwate Medical University, School of Medicine, Morioka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.02.011DOI Listing

Four phenotypes of atopic dermatitis in Japanese children: A general population birth cohort study.

Allergol Int 2019 Mar 30. Epub 2019 Mar 30.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan; Medical Support Center for the Japan Environment and Children's Study, Research Institute, National Center for Child Health and Development, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.02.010DOI Listing
March 2019
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Long-term outcomes after sustained unresponsiveness in patients who underwent oral immunotherapy for egg, cow's milk, or wheat allergy.

Allergol Int 2019 Mar 29. Epub 2019 Mar 29.

Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.02.012DOI Listing
March 2019
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What we know, do not know, and should know about severe asthma.

Allergol Int 2019 Apr;68(2):133-134

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.03.002DOI Listing
April 2019
2 Reads

Food-dependent exercise-induced anaphylaxis due to pickled Japanese apricot.

Allergol Int 2019 Mar 28. Epub 2019 Mar 28.

Department of Food Science, Kyoto Women's University, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.02.009DOI Listing
March 2019
1 Read

A case of anaphylaxis due to alpha-mannosidase from Auricularia.

Allergol Int 2019 Mar 26. Epub 2019 Mar 26.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.02.008DOI Listing
March 2019
2 Reads

Eosinophilic fasciitis: From pathophysiology to treatment.

Authors:
Hironobu Ihn

Allergol Int 2019 Mar 22. Epub 2019 Mar 22.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:

Eosinophilic fasciitis is a disease originally proposed as "diffuse fasciitis with eosinophilia" by Shulman in 1974. The patients with this disease often have history of strenuous exercise or labor a few days to 1-2 weeks before the onset. The chief symptoms are symmetrical, full-circumference swelling and plate-like hardness of the distal limbs. Read More

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http://dx.doi.org/10.1016/j.alit.2019.03.001DOI Listing
March 2019
10 Reads

Severe asthma in Japan.

Authors:
Hiroyuki Nagase

Allergol Int 2019 Apr 13;68(2):167-171. Epub 2019 Mar 13.

Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. Electronic address:

The characteristic phenotype of severe asthma in Japan seems to be distilled into the following two features: low incidence of obesity and high prevalence of patients with type 2 inflammation. Only 5-7% of Japanese severe asthma patients had a body mass index (BMI) ≥30 kg/m, and more than 80% of patients with severe asthma exhibited type 2 inflammation. Although the relationship between obesity and non-type 2 inflammation is complex, the low incidence of obesity might explain the prevalence of type 2 inflammation. Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.004DOI Listing
April 2019
2 Reads

Staphylococcus aureus in atopic dermatitis: Strain-specific cell wall proteins and skin immunity.

Allergol Int 2019 Mar 13. Epub 2019 Mar 13.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Atopic dermatitis (AD) is a common chronic skin disease. The presence of the bacterium Staphylococcus aureus (S. aureus) is frequently detected on skin affected with AD. Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.006DOI Listing

Periostin as a predictor of prognosis in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Mar 11. Epub 2019 Mar 11.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Periostin is an established biomarker of Th2 immune response and fibrogenesis. Recent research has indicated that periostin plays an important role in the pathogenesis of idiopathic interstitial pneumonias. To clarify the relationship between periostin and pathogenesis in chronic bird-related hypersensitivity pneumonitis (HP) and to reveal the usefulness of serum periostin levels in diagnosing and managing chronic bird-related HP. Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.007DOI Listing
March 2019
2 Reads

Low-dose l-isoproterenol versus salbutamol in hospitalized pediatric patients with severe acute exacerbation of asthma: A double-blind, randomized controlled trial.

Allergol Int 2019 Mar 5. Epub 2019 Mar 5.

Department of Development Strategy, Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan.

Background: Although the guidelines in most countries do not recommend continuous inhalation of l-isoproterenol to treat pediatric patients with acute severe exacerbation of asthma, lower dose of l-isoproterenol has been widely used in Japan. To determine whether the efficacy of low-dose l-isoproterenol was superior to that of salbutamol, we conducted a double-blind, randomized controlled trial.

Methods: Hospitalized patients aged 1-17 years were eligible if they had severe asthma exacerbation defined by the modified pulmonary index score (MPIS). Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.001DOI Listing
March 2019
1 Read

Sublingual administration of liposomes enclosing alpha-galactosylceramide as an effective adjuvant of allergen immunotherapy in a murine model of allergic rhinitis.

Allergol Int 2019 Feb 22. Epub 2019 Feb 22.

Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Background: Sublingual immunotherapy (SLIT) is an established efficacious approach for the treatment of allergic rhinitis (AR). However, SLIT requires a long administration period to establish stable and adequate responses. This study investigated the efficacy of the sublingual administration of an allergen with liposomes enclosing α-GalCer (α-GC-liposome) as a potential adjuvant in mice with AR. Read More

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http://dx.doi.org/10.1016/j.alit.2019.02.003DOI Listing
February 2019
1 Read

Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs.

Allergol Int 2019 Feb 22. Epub 2019 Feb 22.

Allergy and Immunology Research Project Team, Nihon University School of Medicine, Tokyo, Japan; Center for Institutional Research and Medical Education, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

Background: The reported prevalences of IgG autoantibodies (AAbs) to FcεRIα and IgE in sera from patients with chronic spontaneous urticaria (CSU) have varied, and these AAbs are also often observed in healthy control subjects. Regarding the histamine release activity of purified IgG from patients with CSU, the number of examined patients has been small. Thus, we sought to determine the prevalence and FcεRI crosslinking ability of these AAbs in a large number of patients with CSU and non-atopic control (NC) subjects. Read More

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http://dx.doi.org/10.1016/j.alit.2019.01.003DOI Listing
February 2019
1 Read

Basophil count is a sensitive marker for clinical progression in a chronic spontaneous urticaria patient treated with omalizumab.

Allergol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, Kansai Medical University, Hirakata, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.02.002DOI Listing
February 2019
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Biological treatments for severe asthma: A major advance in asthma care.

Authors:
William W Busse

Allergol Int 2019 Apr 18;68(2):158-166. Epub 2019 Feb 18.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

Asthma is a heterogeneous disease with considerable variability noted in disease severity, patterns of airway inflammation, and achievement of disease control on current medications. An absence of disease control is most frequently noted in patients with severe asthma, and is defined as a lack of control while on high dose inhaled corticosteroids (ICS) plus a second controller medication. In part, this lack of control may relate to a diminished effect of current guideline-directed care on the existing pattern of airway inflammation in severe asthma. Read More

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http://dx.doi.org/10.1016/j.alit.2019.01.004DOI Listing
April 2019
6 Reads

Forced oscillation technique may identify asthma-COPD overlap.

Allergol Int 2019 Feb 7. Epub 2019 Feb 7.

Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.01.002DOI Listing
February 2019
2 Reads

Association between chemical components of PM and children's primary care night-time visits due to asthma attacks: A case-crossover study.

Allergol Int 2019 Feb 7. Epub 2019 Feb 7.

Himeji Medical Association, Himeji, Japan.

Background: Few papers have examined the association between the chemical components of PM and health effects. The existence of an association is now under discussion.

Methods: This case-crossover study aimed to examine the association between the chemical components of PM and night-time primary care visits (PCVs) due to asthma attacks. Read More

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http://dx.doi.org/10.1016/j.alit.2019.01.001DOI Listing
February 2019
7 Reads

Urban/rural residence effect on emergency department visits arising from food-induced anaphylaxis.

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Pediatrics and Adolescent Medicine, Juntendo University, School of Medicine, Tokyo, Japan.

Background: Anaphylaxis is a severe and potentially fatal allergic response. Early-life exposure to rural environments may help protect against allergic reaction. This study assesses urban/rural differences by age and race/ethnicity in emergency department (ED) pediatric visit rates for food-induced anaphylaxis. Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.007DOI Listing
February 2019
14 Reads

Acute inflammatory and immunologic responses against antigen in chronic bird-related hypersensitivity pneumonitis.

Allergol Int 2019 Feb 5. Epub 2019 Feb 5.

Department of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

Background: Hypersensitivity pneumonitis (HP) is an immune-mediated lung disease induced by the inhalation of a wide variety of antigens and a persistent antigen exposure induces inevitably pulmonary fibrosis in chronic HP. Although neutrophils, Th1 and Th17 cells contribute to lung inflammation in acute phase of HP, there is no clear explanation as to how the immunological reaction occurs just after the inhalation of causative antigens in the chronic phase of HP.

Methods: We examined the inflammatory and immunologic profiles before and after the inhalation provocation test (IPT) in serum and bronchoalveolar lavage fluid (BALF) from patients with chronic bird-related HP (BRHP) and other interstitial lung diseases (ILDs). Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.010DOI Listing
February 2019
2 Reads

Development of conjunctivitis with a conjunctival proliferative lesion in a patient treated with dupilumab for atopic dermatitis.

Allergol Int 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kochi, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.12.012DOI Listing
February 2019

A very rare case of allergy to beluga caviar.

Allergol Int 2019 Jan 30. Epub 2019 Jan 30.

St Anthony's Hospital, North Cheam, Surrey, UK. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2018.12.009DOI Listing
January 2019

Development of a liquid chromatography-tandem mass spectrometry method for quantification of the egg allergen ovalbumin in rat plasma.

Allergol Int 2019 Jan 30. Epub 2019 Jan 30.

Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2018.12.005DOI Listing
January 2019

Age-related changes in serum periostin level in allergic and non-allergic children.

Allergol Int 2019 Apr 31;68(2):285-286. Epub 2019 Jan 31.

Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.12.006DOI Listing
April 2019
3 Reads

Case series of allergic bronchopulmonary aspergillosis treated successfully and safely with long-term mepolizumab.

Allergol Int 2019 Jan 28. Epub 2019 Jan 28.

Department of Allergy and Respiratory Medicine, The Fraternity Memorial Hospital, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2018.12.008DOI Listing
January 2019
3 Reads

Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia.

Allergol Int 2019 Jan 19. Epub 2019 Jan 19.

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.12.004DOI Listing
January 2019
2 Reads

Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency.

Allergol Int 2019 Apr 19;68(2):172-177. Epub 2019 Jan 19.

Department of Allergy, Aichi Children's Health and Medical Center, Aichi, Japan.

The season of birth and ultraviolet B exposure have been related to the occurrence of food allergy. The levels of vitamin D produced from skin by ultraviolet B exposure might reflect this relationship. Vitamin D is known to induce antimicrobial peptides, protect intestinal flora, enhance the gut epithelial barrier, suppress mast cell activation and IgE synthesis from B cells, and increase the number of tolerogenic dendritic cells and IL-10-producing regulatory T cells. Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.003DOI Listing
April 2019
1 Read

Severe asthma in children: Evaluation and management.

Allergol Int 2019 Apr 14;68(2):150-157. Epub 2019 Jan 14.

Harvard Medical School, Boston, MA, USA; Division of Allergy and Immunology, Boston Children's Hospital, Boston, MA, USA. Electronic address:

Severe asthma in children is associated with significant morbidity. Children with severe asthma are at increased risk for adverse outcomes including medication-related side effects, life-threatening exacerbations, and impaired quality of life. It is important to differentiate between severe therapy resistant asthma and difficult-to-treat asthma due to comorbidities. Read More

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http://dx.doi.org/10.1016/j.alit.2018.11.007DOI Listing
April 2019
3 Reads

Thermography: High sensitivity and specificity diagnosing contact dermatitis in patch testing.

Allergol Int 2019 Apr 29;68(2):254-258. Epub 2018 Dec 29.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland; Competence Center Personalized Medicine, University of Zurich and ETH Zurich, Zurich, Switzerland. Electronic address:

Background: Patch testing of contact allergens to diagnose allergic contact dermatitis (ACD) is a traditional, useful tool. The most important decision is the distinction between allergic and irritant reactions, as this has direct implications on diagnosis and management. Our objective was to evaluate a new method of non-contact infrared reading of patch tests. Read More

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http://dx.doi.org/10.1016/j.alit.2018.12.001DOI Listing
April 2019
5 Reads

New trends in mucosal immunology and allergy.

Allergol Int 2019 Jan;68(1):1-3

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183016
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http://dx.doi.org/10.1016/j.alit.2018.12.002DOI Listing
January 2019
11 Reads

Non-type 2 inflammation in severe asthma is propelled by neutrophil cytoplasts and maintained by defective resolution.

Allergol Int 2019 Apr 17;68(2):143-149. Epub 2018 Dec 17.

Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Asthma is a highly prevalent heterogeneous inflammatory disorder of the airways. Not all patients respond to anti-inflammatory treatment with corticosteroids, leading to significant morbidity in severe asthma. Much attention has been paid to defining the cellular and molecular mechanisms of type 2 inflammation that are operative in asthma. Read More

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http://dx.doi.org/10.1016/j.alit.2018.11.006DOI Listing
April 2019
1 Read

Intestinal absorption of the wheat allergen gliadin in rats.

Allergol Int 2019 Apr 15;68(2):247-253. Epub 2018 Dec 15.

Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: Aspirin enhances food allergy symptoms by increasing absorption of ingested allergens. The objective of this study is to elucidate the role of aspirin in facilitating intestinal absorption of the wheat allergen, gliadin, in rats.

Methods: Plasma concentrations of gliadin were determined after oral administration by gavage or administration into a closed intestinal loop in rats. Read More

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http://dx.doi.org/10.1016/j.alit.2018.11.005DOI Listing
April 2019
2 Reads

The Urticaria Control Test and Urticaria Activity Score correlate with quality of life in adult Japanese patients with chronic spontaneous urticaria.

Allergol Int 2019 Apr 4;68(2):279-281. Epub 2018 Dec 4.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183015
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http://dx.doi.org/10.1016/j.alit.2018.11.003DOI Listing
April 2019
8 Reads

Bird-egg syndrome induced by α-livetin sensitization in a budgerigar keeper: Successful induction of tolerance by avoiding exposure to avians.

Allergol Int 2019 Apr 4;68(2):282-284. Epub 2018 Dec 4.

Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.11.004DOI Listing
April 2019
1 Read

Obesity and severe asthma.

Allergol Int 2019 Apr 1;68(2):135-142. Epub 2018 Dec 1.

Department of Environmental Health, Harvard University T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Obesity is an important global health issue for both children and adults. Obesity increases the prevalence and incidence of asthma and also increases the risk for severe asthma. Here we describe the features of severe asthma phenotypes for which obesity is a defining characteristic, including steroid resistance, airway inflammation, and co-morbidities. Read More

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http://dx.doi.org/10.1016/j.alit.2018.10.004DOI Listing
April 2019
6 Reads

Airway innate lymphoid cells in the induction and regulation of allergy.

Allergol Int 2019 Jan 23;68(1):9-16. Epub 2018 Nov 23.

Department of Medicine, University of California, San Diego, CA, USA. Electronic address:

The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). ILCs are divided into group 1 (ILC1s), group 2 (ILC2s), or group 3 (ILC3s). Read More

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http://dx.doi.org/10.1016/j.alit.2018.11.001DOI Listing
January 2019
7 Reads

Obesity, but not metabolic syndrome, as a risk factor for late-onset asthma in Japanese women.

Allergol Int 2019 Apr 23;68(2):240-246. Epub 2018 Nov 23.

Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan.

Background: Several cross-sectional studies have suggested an association between obesity and asthma. However, few studies have investigated this relationship longitudinally, especially in middle-aged subjects. Although metabolic syndrome is a well-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183015
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http://dx.doi.org/10.1016/j.alit.2018.10.003DOI Listing
April 2019
16 Reads

Critical role of platelets in the production of thymus and activation-regulated chemokine in children: A case series study.

Allergol Int 2019 Apr 22;68(2):277-278. Epub 2018 Nov 22.

Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.11.002DOI Listing
April 2019
1 Read

Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation.

Allergol Int 2019 Jan 10;68(1):4-8. Epub 2018 Nov 10.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Asthma is the most prevalent allergic disease of the airway, which is characterized by eosinophilic inflammation, mucus hyperproduction, and airway hyper-responsiveness. Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. IL-22, one of the cytokines produced by Th17 cells and type 3 ILCs, has distinct functional properties, as IL-22 exclusively acts on non-hematopoietic cells including epithelial cells of mucosal surface and exhibits a broad range of action in regeneration and host protection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
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http://dx.doi.org/10.1016/j.alit.2018.10.002DOI Listing
January 2019
15 Reads

Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis.

Allergol Int 2019 Apr 9;68(2):233-239. Epub 2018 Nov 9.

Laboratory of Ocular Atopic Diseases, Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:

Background: To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis.

Methods: The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue. Read More

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http://dx.doi.org/10.1016/j.alit.2018.09.007DOI Listing
April 2019
3 Reads

Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: A double-blind, randomized, multicenter, placebo-controlled clinical trial.

Allergol Int 2019 Apr 31;68(2):207-215. Epub 2018 Oct 31.

Teikoku Seiyaku Co., Ltd., Kagawa, Japan.

Background: Rupatadine is a novel non-sedating second-generation H-antihistamine with antiplatelet-activating factor activity, first marketed in Spain in 2003. It is used for treating allergic rhinitis in more than 80 countries. This study investigated its efficacy and safety in Japanese patients with seasonal allergic rhinitis (SAR). Read More

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http://dx.doi.org/10.1016/j.alit.2018.08.011DOI Listing
April 2019
6 Reads

A comprehensive understanding of the gut mucosal immune system in allergic inflammation.

Allergol Int 2019 Jan 23;68(1):17-25. Epub 2018 Oct 23.

Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA. Electronic address:

Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from the invasion of infectious pathogens and eliminates harmful non-self antigens, but it allows the cohabitation of commensal bacteria in the gut and the entry of dietary non-self antigens into the body via the mucosal surface. These physiological and immunological activities are regulated by the ingenious gut mucosal immune network, comprising such features as gut-associated lymphoid tissue, mucosal immune cells, cytokines, chemokines, antimicrobial peptides, secretory IgA, and commensal bacteria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
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http://dx.doi.org/10.1016/j.alit.2018.09.004DOI Listing
January 2019
23 Reads

Identification of biomarkers for predicting the response to cyclosporine A therapy in patients with chronic spontaneous urticaria.

Allergol Int 2019 Apr 22;68(2):270-273. Epub 2018 Oct 22.

Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan; Center for Institutional Research and Medical Education, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2018.09.006DOI Listing
April 2019
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Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis.

Allergol Int 2019 Apr 19;68(2):225-232. Epub 2018 Oct 19.

Division of Otorhinolaryngology Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, Japan.

Background: In Eosinophilic chronic rhinosinusitis (ECRS), it is difficult to estimate the refractoriness and recurrence risk for each patient. Fraction of exhaled nitric oxide (FeNO) is known as a biomarker of eosinophilic inflammation in lower airway. It has been reported that nasal NO has some crucial functions in the upper and lower airways. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
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http://dx.doi.org/10.1016/j.alit.2018.09.005DOI Listing
April 2019
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SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases.

Allergol Int 2019 Apr 19;68(2):274-276. Epub 2018 Oct 19.

Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2018.10.001DOI Listing
April 2019
4 Reads