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    1009 results match your criteria Allergology International[Journal]

    1 OF 21

    Barrier dysfunction in the nasal allergy.
    Allergol Int 2017 Nov 14. Epub 2017 Nov 14.
    Department of Immunology, Hyogo College of Medicine, Hyogo, Japan; Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan. Electronic address:
    Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell-cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Read More

    Efficacy and safety of benralizumab in Japanese patients with severe, uncontrolled eosinophilic asthma.
    Allergol Int 2017 Nov 8. Epub 2017 Nov 8.
    AstraZeneca, Gaithersburg, MD, USA.
    Background: In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial.

    Methods: CALIMA was a randomised, controlled trial of 1306 patients (aged 12-75 years; registered at ClinicalTrials. Read More

    Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus.
    Allergol Int 2017 Nov 6. Epub 2017 Nov 6.
    Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan. Electronic address:
    Background: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. Read More

    Efficacy and safety of omalizumab for the treatment of refractory chronic spontaneous urticaria in Japanese patients: Subgroup analysis of the phase 3 POLARIS study.
    Allergol Int 2017 Nov 1. Epub 2017 Nov 1.
    Novartis Pharma AG, Basel, Switzerland. Electronic address:
    Background: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g. Read More

    Phenotype classification using the combination of lung sound analysis and fractional exhaled nitric oxide for evaluating asthma treatment.
    Allergol Int 2017 Oct 21. Epub 2017 Oct 21.
    San Remo Rehabilitation Hospital, Sasebo, Japan.
    Background: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment.

    Methods: A total of 233 patients with bronchial asthma were included. Read More

    Chronic spontaneous urticaria and the extrinsic coagulation system.
    Allergol Int 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:
    Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. Read More

    Therapeutic approaches of asthma and COPD overlap.
    Allergol Int 2017 Sep 28. Epub 2017 Sep 28.
    The First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. Electronic address:
    Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. Read More

    A case of clinically amyopathic dermatomyositis that developed during anti-TNF-α therapy for rheumatoid arthritis.
    Allergol Int 2017 Sep 27. Epub 2017 Sep 27.
    Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.

    Role of airway epithelial barrier dysfunction in pathogenesis of asthma.
    Allergol Int 2017 Sep 20. Epub 2017 Sep 20.
    Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Read More

    Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a murine food allergy model.
    Allergol Int 2017 Sep 18. Epub 2017 Sep 18.
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.

    Mast cells derived from human induced pluripotent stem cells are useful for allergen tests.
    Allergol Int 2017 Sep 14. Epub 2017 Sep 14.
    Department of Pediatric, National Hospital Organization Shinshu Ueda Medical Center, Nagano, Japan.
    Background: Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Read More

    Exposure amount and timing of solar irradiation during pregnancy and the risk of sensitization in children.
    Allergol Int 2017 Sep 4. Epub 2017 Sep 4.
    Department of Pediatrics, CHA University School of Medicine, Seongnam, South Korea. Electronic address:
    Background: Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. Read More

    Role of the microbiota in skin immunity and atopic dermatitis.
    Allergol Int 2017 Oct 4;66(4):539-544. Epub 2017 Sep 4.
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
    Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. Read More

    Hand eczema as a risk factor for food allergy among occupational kitchen workers.
    Allergol Int 2017 Sep 2. Epub 2017 Sep 2.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Background: An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. Read More

    Development of a questionnaire to evaluate asthma control in Japanese asthma patients.
    Allergol Int 2017 Aug 31. Epub 2017 Aug 31.
    NPO Sapporo Cough Asthma and Allergy Center, Sapporo, Japan.
    Background: The asthma control questionnaires used in Japan are Japanese translations of those developed outside Japan, and have some limitations; a questionnaire designed to optimally evaluate asthma control levels for Japanese may be necessary. The present study was conducted to validate the Japan Asthma Control Survey (JACS) questionnaire in Japanese asthma patients.

    Methods: A total of 226 adult patients with mild to severe persistent asthma were enrolled and responded to the JACS questionnaire, asthma control questionnaire (ACQ), and Mini asthma quality of life questionnaire (Mini AQLQ) at Weeks 0 and 4. Read More

    Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention.
    Allergol Int 2017 Oct 1;66(4):529-538. Epub 2017 Sep 1.
    inFLAME Global Network (Worldwide Universities Network), West New York, NJ, USA; Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Large-scale biodiversity loss and complex changes in social behaviors are altering human microbial ecology. This is increasingly implicated in the global rise in inflammatory diseases, most notably the "allergy epidemic" in very early life. Colonization of human ecological niches, particularly the gastrointestinal tract, is critical for normal local and systemic immune development and regulation. Read More

    Development of the gut microbiota in infancy and its impact on health in later life.
    Allergol Int 2017 Oct 18;66(4):515-522. Epub 2017 Aug 18.
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan. Electronic address:
    Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. Read More

    Surveillance of the use of adrenaline auto-injectors in Japanese children.
    Allergol Int 2017 Aug 4. Epub 2017 Aug 4.
    Anaphylaxis Working Group, The Japanese Society of Pediatric Allergy and Clinical Immunology, Tokyo, Japan; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Kanagawa, Japan.
    Background: The appropriate usage of an adrenaline auto-injector (AAI, Epipen(®)) is a key aspect of patient and social education in the management of anaphylaxis. However, although AAIs are being prescribed increasingly frequently, there are few reports on their actual use.

    Methods: The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which AAIs were used. Read More

    Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study.
    Allergol Int 2017 Aug 1. Epub 2017 Aug 1.
    Allergy Center, Mie National Hospital, Mie, Japan; Department of Education for Childcare, Faculty of Child Studies, Tokyo Kasei University, Saitama, Japan.
    Background: Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL).

    Methods: We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. Read More

    An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis.
    Allergol Int 2017 Jul 28. Epub 2017 Jul 28.
    Allergy and Head and Neck Tumor Center, Southern Tohoku General Hospital, Fukushima, Japan.
    Background: Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN(®)).

    Methods: The study included 482 patients who had previously completed a phase 3 trial during two seasons. Read More

    Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice.
    Allergol Int 2017 Sep 26;66S:S35-S40. Epub 2017 Jul 26.
    Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
    Background: Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate antigen-induced airway eosinophilia and bronchial hyperresponsiveness (BHR), the sensitivity of Th9 cell-mediated responses to steroid therapy remains unknown. In this study, we investigated the effect of dexamethasone (Dex) on antigen-induced airway inflammation in Th9 cell-transferred mice. Read More

    Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate.
    Allergol Int 2017 Jul 25. Epub 2017 Jul 25.
    Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil. Electronic address:
    Background: Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams.

    Methods: It was performed a retrospective analysis of laboratory, histopathology and direct immunofluorescence data of 93 patients with chronic urticaria. Read More

    Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients.
    Allergol Int 2017 Jul 19. Epub 2017 Jul 19.
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Background: Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients. Read More


    Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia.
    Allergol Int 2017 Sep 10;66S:S27-S34. Epub 2017 Jul 10.
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.
    Background: Recent evidence has suggested that the innate immune response may play a role in the development of eosinophilic airway inflammation. We previously reported that uric acid (UA) and adenosine triphosphate (ATP), two important damage-associated molecular pattern molecules (DAMPs), activate eosinophil functions, suggesting that these molecules may be involved in the development of eosinophilic airway inflammation. The objective of this study was to measure the concentrations of DAMPs including UA and ATP in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). Read More

    Gut microbiome, metabolome, and allergic diseases.
    Allergol Int 2017 Oct 8;66(4):523-528. Epub 2017 Jul 8.
    Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Hyogo, Japan; Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Osaka, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:
    The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both useful and harmful metabolites from dietary materials. Read More


    Flow cytometry-based diagnosis of primary immunodeficiency diseases.
    Allergol Int 2017 Jul 3. Epub 2017 Jul 3.
    Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
    Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Read More

    Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice.
    Allergol Int 2017 Jul 1. Epub 2017 Jul 1.
    Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi, Japan.
    Background: We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.

    Methods: BALB/c mice were sensitized with two intraperitoneal injections of Japanese cedar pollen in alum, challenged with pollen in eyedrops, and then fed for 16 days with transgenic rice seeds expressing modified Japanese cedar pollen allergens Cry j 1 and Cry j 2 or with nontransgenic rice seeds as a control. Read More

    Neuropsychiatry phenotype in asthma: Psychological stress-induced alterations of the neuroendocrine-immune system in allergic airway inflammation.
    Allergol Int 2017 Sep 29;66S:S2-S8. Epub 2017 Jun 29.
    Center for Medical Education, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. Electronic address:
    Since the recognition of asthma as a syndrome with complex pathophysiological signs and symptoms, recent research has sought to classify asthma phenotypes based on its clinical and molecular pathological features. Psychological stress was first recognized as a potential immune system modulator of asthma at the end of the 19th century. The activation of the central nervous system (CNS) upon exposure to psychological stress is integral for the initiation of signal transduction processes. Read More

    Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis.
    Allergol Int 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, Integrated Health Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:
    Background: Atopic dermatitis (AD) is exacerbated by sweating, and the skin of most patients with AD are resided by Malassezia (M.) fungi. Recently, MGL_1304 produced by Malasseziaglobosa was identified as the major histamine releasing antigen in human sweat. Read More

    The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation.
    Allergol Int 2017 Jun 22. Epub 2017 Jun 22.
    Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan. Electronic address:
    Background: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. Read More

    IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy.
    Allergol Int 2017 Jun 21. Epub 2017 Jun 21.
    Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland. Electronic address:
    Background: Interleukin-17 (IL-17A) is a mainly pro-inflammatory cytokine, and IL-17 signaling implicates in the development of allergic asthma. The polymorphism rs2275913 in the promoter region of the IL-17A gene has in previous studies been associated with asthma susceptibility. The objective was to evaluate the association between IL-17A rs2275913 (-197G>A) polymorphism and post-bronchiolitis asthma and/or allergic rhinitis in a prospective 11-13 years post-bronchiolitis follow-up. Read More

    Leukotriene receptor antagonist attenuated airway inflammation and hyperresponsiveness in a double-stranded RNA-induced asthma exacerbation model.
    Allergol Int 2017 Sep 21;66S:S21-S26. Epub 2017 Jun 21.
    Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. Electronic address:
    Background: Viral infections are the most common triggers of asthma exacerbation, but the key molecules involved in this process have not been fully identified. Although cysteinyl leukotrienes (cysLTs) have been postulated as the key mediators, their precise roles remain largely unclear. To investigate the roles of cysLTs in virus-induced asthma exacerbation, we developed a murine model using a viral double-stranded RNA analog, polyinosinic-polycytidylic acid (poly I:C), and analyzed the effect of leukotriene receptor antagonist (LTRA) administration. Read More

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