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    1021 results match your criteria Allergology International[Journal]

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    ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan.

    Recent advances in understanding the roles of blood platelets in the pathogenesis of allergic inflammation and bronchial asthma.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. Electronic address:
    Platelets play an essential role in hemostasis to minimize blood loss due to traumatic injury. In addition, they contain various immune-associated molecules and contribute to immunological barrier formation at sites of vascular injury, thereby protecting against invading pathogens. Platelets are also crucially involved in development of allergic diseases, including bronchial asthma. Read More

    Increased ratio of pollock roe-specific IgE to salmon roe-specific IgE levels is associated with a positive reaction to cooked pollock roe oral food challenge.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan. Electronic address:
    Background: Anaphylaxis and immediate-type fish roe allergies have been reported worldwide, and, in Japan, fish roe is the sixth most common food allergen. No oral food challenges (OFCs) have used pollock roe (PR), which is reported to have high cross-reactivity with salmon roe (SR). Therefore, we administered an OFC using cooked PR to evaluate PR- and SR-specific immunoglobulin E (IgE) levels and allergic reactions in patients with PR sensitivity. Read More

    Recent advancement to prevent the development of allergy and allergic diseases and therapeutic strategy in the perspective of barrier dysfunction.
    Allergol Int 2018 Jan 7;67(1):24-31. Epub 2017 Dec 7.
    Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address:
    Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march. Read More

    Long-term safety of subcutaneous immunotherapy with TO-204 in Japanese patients with house dust mite-induced allergic rhinitis and allergic bronchial asthma: Multicenter, open label clinical trial.
    Allergol Int 2017 Dec 7. Epub 2017 Dec 7.
    Department of Clinical Development, Torii Pharmaceutical Co., Ltd., Tokyo, Japan.
    Background: To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial.

    Methods: Japanese patients aged 5-65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria. Read More

    Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects.
    Allergol Int 2017 Dec 6. Epub 2017 Dec 6.
    Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
    Background: Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. Read More

    Th1-related disease development during omalizumab treatment: Two cases with severe asthma.
    Allergol Int 2017 Nov 27. Epub 2017 Nov 27.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. Electronic address:

    Surfing as a risk factor for sensitization to poly(γ-glutamic acid) in fermented soybeans, natto, allergy.
    Allergol Int 2017 Nov 24. Epub 2017 Nov 24.
    Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.
    Background: Poly(γ-glutamic acid) (PGA) is an allergen in natto, fermented soybeans, which causes late-onset anaphylaxis. We hypothesized that jellyfish stings sensitize adults to PGA because a surfer had allergies to both natto and jellyfish, whose sting contains PGA. The aim of the study was to identify behavioral factors, such as marine sports, associated with PGA sensitization. Read More

    Barrier dysfunction in the skin allergy.
    Allergol Int 2018 Jan 16;67(1):3-11. Epub 2017 Nov 16.
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; PRESTO, Japan Science and Technology Agency, Saitama, Japan. Electronic address:
    The skin is continuously exposed to external pathogens, and its barrier function is critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one of the most predisposing factors for the development of skin allergic diseases such as atopic dermatitis. In this article, we summarize how the physical barrier of the skin is organized and review its link to the pathomechanism of skin allergic diseases. Read More

    Barrier dysfunction in the nasal allergy.
    Allergol Int 2018 Jan 14;67(1):18-23. Epub 2017 Nov 14.
    Department of Immunology, Hyogo College of Medicine, Hyogo, Japan; Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan. Electronic address:
    Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell-cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases. Read More

    Efficacy and safety of benralizumab in Japanese patients with severe, uncontrolled eosinophilic asthma.
    Allergol Int 2017 Nov 8. Epub 2017 Nov 8.
    AstraZeneca, Gaithersburg, MD, USA.
    Background: In the Phase III CALIMA trial, benralizumab significantly reduced asthma exacerbations, increased lung function, and alleviated symptoms for patients with severe, uncontrolled eosinophilic asthma. The aim of this subgroup analysis was to evaluate the efficacy and safety of benralizumab for Japanese patients in the CALIMA trial.

    Methods: CALIMA was a randomised, controlled trial of 1306 patients (aged 12-75 years; registered at ClinicalTrials. Read More

    Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus.
    Allergol Int 2017 Nov 6. Epub 2017 Nov 6.
    Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan. Electronic address:
    Background: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated. Read More

    Efficacy and safety of omalizumab for the treatment of refractory chronic spontaneous urticaria in Japanese patients: Subgroup analysis of the phase 3 POLARIS study.
    Allergol Int 2017 Nov 1. Epub 2017 Nov 1.
    Novartis Pharma AG, Basel, Switzerland. Electronic address:
    Background: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g. Read More

    Phenotype classification using the combination of lung sound analysis and fractional exhaled nitric oxide for evaluating asthma treatment.
    Allergol Int 2017 Oct 21. Epub 2017 Oct 21.
    San Remo Rehabilitation Hospital, Sasebo, Japan.
    Background: We report the utility of combining lung sound analysis and fractional exhaled nitric oxide (FeNO) for phenotype classification of airway inflammation in patients with bronchial asthma. We investigated the usefulness of the combination of the expiration-to-inspiration sound power ratio in the mid-frequency range (E/I MF) of 200-400 Hz and FeNO for comprehensively classifying disease type and evaluating asthma treatment.

    Methods: A total of 233 patients with bronchial asthma were included. Read More

    Chronic spontaneous urticaria and the extrinsic coagulation system.
    Allergol Int 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:
    Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. Read More

    Therapeutic approaches of asthma and COPD overlap.
    Allergol Int 2017 Sep 28. Epub 2017 Sep 28.
    The First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. Electronic address:
    Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and high economic burden. However, no large-scaled therapeutic trials of ACO have been conducted. At present, ACO is treated according to asthma/COPD guidelines. Read More

    A case of clinically amyopathic dermatomyositis that developed during anti-TNF-α therapy for rheumatoid arthritis.
    Allergol Int 2017 Sep 27. Epub 2017 Sep 27.
    Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan.

    Role of airway epithelial barrier dysfunction in pathogenesis of asthma.
    Allergol Int 2018 Jan 21;67(1):12-17. Epub 2017 Sep 21.
    Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Read More

    Vitamin D deficiency exacerbates sensitization and allergic diarrhea in a murine food allergy model.
    Allergol Int 2017 Sep 18. Epub 2017 Sep 18.
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.

    Mast cells derived from human induced pluripotent stem cells are useful for allergen tests.
    Allergol Int 2017 Sep 14. Epub 2017 Sep 14.
    Department of Pediatric, National Hospital Organization Shinshu Ueda Medical Center, Nagano, Japan.
    Background: Several methods have been developed to detect allergen-specific IgE in sera. The passive IgE sensitization assay using human IgE receptor-expressing rat cell line RBL-2H3 is a powerful tool to detect biologically active allergen-specific IgE in serum samples. However, one disadvantage is that RBL-2H3 cells are vulnerable to high concentrations of human sera. Read More

    Exposure amount and timing of solar irradiation during pregnancy and the risk of sensitization in children.
    Allergol Int 2017 Sep 4. Epub 2017 Sep 4.
    Department of Pediatrics, CHA University School of Medicine, Seongnam, South Korea. Electronic address:
    Background: Solar irradiation affects sensitization to aeroallergens and the prevalence of allergic diseases. Little is known, however, about how the time and amount of solar irradiation during pregnancy affects such risks in children. We aimed to find out how solar irradiation during pregnancy affects sensitization to aero-allergens and the prevalence of allergic diseases in children. Read More

    Role of the microbiota in skin immunity and atopic dermatitis.
    Allergol Int 2017 Oct 4;66(4):539-544. Epub 2017 Sep 4.
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
    Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. Read More

    Hand eczema as a risk factor for food allergy among occupational kitchen workers.
    Allergol Int 2017 Sep 2. Epub 2017 Sep 2.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan; Course of Allergy and Clinical Immunology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Background: An increasing number of studies in children is highlighting the importance of transdermal routes of exposure to food allergens through damaged skin in the pathogenesis of food allergies. However, data on this in adults are limited. A few case-series studies has documented development of food allergy among kitchen workers with hand eczema after direct contact exposure to foods. Read More

    Development of a questionnaire to evaluate asthma control in Japanese asthma patients.
    Allergol Int 2018 Jan 1;67(1):131-137. Epub 2017 Sep 1.
    NPO Sapporo Cough Asthma and Allergy Center, Sapporo, Japan.
    Background: The asthma control questionnaires used in Japan are Japanese translations of those developed outside Japan, and have some limitations; a questionnaire designed to optimally evaluate asthma control levels for Japanese may be necessary. The present study was conducted to validate the Japan Asthma Control Survey (JACS) questionnaire in Japanese asthma patients.

    Methods: A total of 226 adult patients with mild to severe persistent asthma were enrolled and responded to the JACS questionnaire, asthma control questionnaire (ACQ), and Mini asthma quality of life questionnaire (Mini AQLQ) at Weeks 0 and 4. Read More

    Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention.
    Allergol Int 2017 Oct 1;66(4):529-538. Epub 2017 Sep 1.
    inFLAME Global Network (Worldwide Universities Network), West New York, NJ, USA; Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Large-scale biodiversity loss and complex changes in social behaviors are altering human microbial ecology. This is increasingly implicated in the global rise in inflammatory diseases, most notably the "allergy epidemic" in very early life. Colonization of human ecological niches, particularly the gastrointestinal tract, is critical for normal local and systemic immune development and regulation. Read More

    Development of the gut microbiota in infancy and its impact on health in later life.
    Allergol Int 2017 Oct 18;66(4):515-522. Epub 2017 Aug 18.
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan. Electronic address:
    Gut microbial ecology and function are dynamic in infancy, but are stabilized in childhood. The 'new friends' have a great impact on the development of the digestive tract and host immune system. In the first year of life, especially, the gut microbiota dramatically changes through interactions with the developing immune system in the gut. Read More

    Surveillance of the use of adrenaline auto-injectors in Japanese children.
    Allergol Int 2017 Aug 4. Epub 2017 Aug 4.
    Anaphylaxis Working Group, The Japanese Society of Pediatric Allergy and Clinical Immunology, Tokyo, Japan; Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Kanagawa, Japan.
    Background: The appropriate usage of an adrenaline auto-injector (AAI, Epipen®) is a key aspect of patient and social education in the management of anaphylaxis. However, although AAIs are being prescribed increasingly frequently, there are few reports on their actual use.

    Methods: The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which AAIs were used. Read More

    Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study.
    Allergol Int 2017 Aug 1. Epub 2017 Aug 1.
    Allergy Center, Mie National Hospital, Mie, Japan; Department of Education for Childcare, Faculty of Child Studies, Tokyo Kasei University, Saitama, Japan.
    Background: Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL).

    Methods: We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. Read More

    An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis.
    Allergol Int 2017 Jul 28. Epub 2017 Jul 28.
    Allergy and Head and Neck Tumor Center, Southern Tohoku General Hospital, Fukushima, Japan.
    Background: Sublingual immunotherapy (SLIT) can improve the symptoms of allergic rhinitis and modify its natural history; however, its efficacy varies among patients. This study aimed to determine which factors modify the effect of SLIT through post hoc analysis of a previous phase 3 trial of standardized Japanese cedar (JC) pollen extract (CEDARTOLEN®).

    Methods: The study included 482 patients who had previously completed a phase 3 trial during two seasons. Read More

    Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice.
    Allergol Int 2017 Sep 26;66S:S35-S40. Epub 2017 Jul 26.
    Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
    Background: Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate antigen-induced airway eosinophilia and bronchial hyperresponsiveness (BHR), the sensitivity of Th9 cell-mediated responses to steroid therapy remains unknown. In this study, we investigated the effect of dexamethasone (Dex) on antigen-induced airway inflammation in Th9 cell-transferred mice. Read More

    Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate.
    Allergol Int 2018 Jan 25;67(1):114-118. Epub 2017 Jul 25.
    Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil. Electronic address:
    Background: Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams.

    Methods: It was performed a retrospective analysis of laboratory, histopathology and direct immunofluorescence data of 93 patients with chronic urticaria. Read More

    Serum levels of squamous cell carcinoma antigens 1 and 2 reflect disease severity and clinical type of atopic dermatitis in adult patients.
    Allergol Int 2018 Jan 19;67(1):124-130. Epub 2017 Jul 19.
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
    Background: Recent studies have indicated that serum levels of squamous cell carcinoma antigen (SCCA) 1 and 2 induced by type 2 cytokines such as IL-4 and IL-13, are increased in patients with atopic dermatitis (AD). However, no clinical studies have analyzed serum levels of SCCA2 in larger series of AD patients or their association with various clinical characteristics. This study was performed to clarify whether serum levels of SCCA2 are associated with disease severity and clinical phenotypes of adult AD patients. Read More


    Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia.
    Allergol Int 2017 Sep 10;66S:S27-S34. Epub 2017 Jul 10.
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.
    Background: Recent evidence has suggested that the innate immune response may play a role in the development of eosinophilic airway inflammation. We previously reported that uric acid (UA) and adenosine triphosphate (ATP), two important damage-associated molecular pattern molecules (DAMPs), activate eosinophil functions, suggesting that these molecules may be involved in the development of eosinophilic airway inflammation. The objective of this study was to measure the concentrations of DAMPs including UA and ATP in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP). Read More

    Gut microbiome, metabolome, and allergic diseases.
    Allergol Int 2017 Oct 8;66(4):523-528. Epub 2017 Jul 8.
    Laboratory of Vaccine Materials and Laboratory of Gut Environmental System, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Hyogo, Japan; Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Osaka, Japan; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:
    The number of patients with allergic and inflammatory disorders has been increasing during the past several decades. Accumulating evidence has refined our understanding of the relationship between allergic diseases and the gut microbiome. In addition, the gut microbiome is now known to produce both useful and harmful metabolites from dietary materials. Read More

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