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    1061 results match your criteria Allergology International[Journal]

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    Quantification of the ω5- and γ-gliadin content in wheat flour and rat plasma with an enzyme-linked immunosorbent assay using antibodies specific to their IgE-binding epitopes.
    Allergol Int 2018 May 19. Epub 2018 May 19.
    Department of Pharmaceutical Services, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

    Characterization of human decidual mast cells and establishment of a culture system.
    Allergol Int 2018 May 18. Epub 2018 May 18.
    Allergy and Immunology Project Team, Nihon University School of Medicine, Tokyo, Japan; Center for Institutional Research and Medical Education, Nihon University School of Medicine, Tokyo, Japan. Electronic address:
    Background: Although rodent decidual mast cells (MCs) reportedly play an important role in implantation and placenta formation, the characterization of human decidual MCs has been not well clarified. The aims of this study were to investigate the distribution and characteristics of MCs in human decidua and to establish a culture system for decidua-derived MCs.

    Methods: Decidual tissues were obtained from patients who underwent a legal elective abortion (6th week to 9th week of pregnancy), and decidual MCs were enzymatically dispersed. Read More

    Concordance between Aspergillus-specific precipitating antibody and IgG in allergic bronchopulmonary aspergillosis.
    Allergol Int 2018 May 15. Epub 2018 May 15.
    Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.
    Background: Several serological tests for specific precipitin or IgG are available to demonstrate type III hypersensitivity reactions to Aspergillus species and are essential for infectious fungal disease diagnosis. These assays are also important for allergic bronchopulmonary aspergillosis (ABPA) diagnosis; however, their concordance in ABPA was not well studied.

    Methods: Fifty-two ABPA patients diagnosed based on ISHAM criteria were enrolled. Read More

    The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases.
    Allergol Int 2018 May 12. Epub 2018 May 12.
    ALK, Hørsholm, Denmark.
    Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. Read More

    Implication of fraction of exhaled nitric oxide and blood eosinophil count in severe asthma.
    Allergol Int 2018 May 10. Epub 2018 May 10.
    Department of Respiratory Medicine, Saitama Medical University, Saitama, Japan; Allergy Center, Saitama Medical University, Saitama, Japan.
    Background: Severe asthma is a complex disease with heterogeneous features and involves type 2 airway inflammation, including eosinophil accumulation. Surrogate biomarkers, fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (b-EOS), may predict eosinophilic airway inflammation. Here we investigated clinical characteristics of severe asthma phenotype using a combined analysis of FeNO and b-EOS. Read More

    Immune suppression of food allergy by maternal IgG in murine models.
    Allergol Int 2018 Apr 30. Epub 2018 Apr 30.
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan.
    Background: Most of the patients develop food allergy early in life. The factors related to parental immune condition might be one of the conceivable causes.

    Methods: We reported murine models of food allergy and oral OVA tolerance. Read More

    Cochineal dye-induced immediate allergy: Review of Japanese cases and proposed new diagnostic chart.
    Allergol Int 2018 Apr 25. Epub 2018 Apr 25.
    Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine, Toyoake, Japan.
    Background: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. Read More


    Severe asthma concomitant with allergic bronchopulmonary aspergillosis successfully treated with mepolizumab.
    Allergol Int 2018 Apr 14. Epub 2018 Apr 14.
    Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Allergy and Respiratory Medicine, Okayama Rosai Hospital, Okayama, Japan. Electronic address:

    Severity of eczema and mental health problems in Japanese schoolchildren: The ToMMo Child Health Study.
    Allergol Int 2018 Apr 13. Epub 2018 Apr 13.
    Department of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Molecular Epidemiology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
    Background: The association between eczema and mental health problems in schoolchildren has been underexplored. We aimed to investigate this association with the validated questionnaires.

    Methods: Of 46,648 invited children, we analyzed 9954 (21. Read More

    Possible involvement of acetylcholine-mediated inflammation in airway diseases.
    Allergol Int 2018 Mar 28. Epub 2018 Mar 28.
    Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address:
    Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs could also possess anti-inflammatory effects. Recent studies have revealed that acetylcholine (ACh) can be synthesized and released from both neuronal and non-neuronal cells, and the released ACh can potentiate airway inflammation and remodeling in airway diseases. Read More

    TARC expression in the circulation and cutaneous granulomas correlates with disease severity and indicates Th2-mediated progression in patients with sarcoidosis.
    Allergol Int 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology, Kansai Medical University, Osaka, Japan.
    Background: Sarcoidosis is a systemic disorder characterized by the accumulation of lymphocytes and monocyte/macrophage lineage cells that results in the formation of non-caseating granulomas. Thymus- and activation-regulated chemokine (TARC)/CCL17 is an important chemokine in the amplification of Th2 responses, which are achieved by recruiting CCR4-expressing CD4 T lymphocytes. TARC concentrations are known to increase in the serum of sarcoidosis patients; however, its role in the assessment of severity and prognosis of sarcoidosis remains unknown. Read More

    Association between impaired IL-10 production following exposure to Staphylococcus aureus enterotoxin B and disease severity in eosinophilic chronic rhinosinusitis.
    Allergol Int 2018 Mar 23. Epub 2018 Mar 23.
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan; Department of Otorhinolaryngology, International University of Health and Welfare Mita Hospital, Tokyo, Japan. Electronic address:
    Background: IL-10 is a major anti-inflammatory cytokine that prevents inflammation-mediated tissue damage. We characterized the production of IL-10 by sinonasal tissue cells following exposure to Staphylococcus aureus enterotoxin B (SEB), which elicits cellular responses and is associated with the pathogenesis of eosinophilic chronic rhinosinusitis (ECRS).

    Methods: Dispersed nasal polyp (NP) cells and uncinate tissue (UT) cells were prepared from patients with CRS with and without NP, respectively. Read More

    Nationwide questionnaire-based survey of oral immunotherapy in Japan.
    Allergol Int 2018 Mar 20. Epub 2018 Mar 20.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan; Study Group on the "Establishment of New Management Method of Food Allergy in Children" in the Practical Research Project for Allergic Disease and Immunology of Japan Agency for Medical Research and Development, AMED, Tokyo, Japan. Electronic address:
    Background: Clinical trials on oral immunotherapy (OIT) have been increasing for nearly a decade; however, several national guidelines do not recommend OIT as a standardized procedure. The aim of this study was to obtain insights into the current use and practice of OIT in Japan.

    Methods: A first questionnaire was mailed to 524 training and teaching facilities of the Japan Pediatric Society. Read More

    Epidemiology of asthma-chronic obstructive pulmonary disease overlap (ACO).
    Allergol Int 2018 Apr 15;67(2):165-171. Epub 2018 Mar 15.
    Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. Electronic address:
    The term "asthma-COPD overlap" (ACO) has been applied to the condition in which a person has persistent airflow limitation with clinical features of both asthma and COPD. The certain definition and diagnostic criteria for ACO have not yet been established, and ACO prevalence has varied widely in studies: from 0.9% to 11. Read More

    The efficacy of sublingual immunotherapy for allergic diseases in Asia.
    Allergol Int 2018 Mar 15. Epub 2018 Mar 15.
    Department of Otolaryngology, Yong loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore. Electronic address:
    Sublingual immunotherapy (SLIT) has been proven to be safe and effective from an abundance of Western literature, but data from Asia is less complete. This review aims to examine the basic science, safety and efficacy of SLIT in Asian patients, and to determine future research needs in Asia. We performed a literature search on PUBMED, Scopus, and Cochrane Library database for articles on SLIT originating from Asian countries through Nov 2017. Read More

    Asthma and COPD overlap pathophysiology of ACO.
    Allergol Int 2018 Apr 15;67(2):179-186. Epub 2018 Mar 15.
    Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
    Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. Read More

    Identification of Cha o 3 homolog Cry j 4 from Cryptomeria japonica (Japanese cedar) pollen: Limitation of the present Japanese cedar-specific ASIT.
    Allergol Int 2018 Mar 7. Epub 2018 Mar 7.
    Discovery and Preclinical Research Division, Taiho Pharmaceutical Co., Ltd., Ibaraki, Japan.
    Background: About one-third of the Japanese population suffers from Japanese cedar pollinosis, which is frequently accompanied by Japanese cypress pollinosis. Recently, a novel major Japanese cypress pollen allergen, Cha o 3, was discovered. However, whether a Cha o 3 homolog is present in Japanese cedar pollen remains to be determined. Read More

    Identifying the factors and root causes associated with the unintentional usage of an adrenaline auto-injector in Japanese children and their caregivers.
    Allergol Int 2018 Mar 5. Epub 2018 Mar 5.
    Department of Allergy, Aichi Children's Health and Medical Center, Aichi, Japan; Anaphylaxis Working Group, The Japanese Society of Pediatric Allergy and Clinical Immunology, Tokyo, Japan. Electronic address:
    Background: The unintentional usage of adrenaline auto-injectors may cause injury to caregivers or patients. To prevent such incidents, we assessed the causative factors of these incidents.

    Methods: The Anaphylaxis Working Group of the Japanese Society of Pediatric Allergy and Clinical Immunology requested that society members register cases in which adrenaline auto-injectors were unintentionally used. Read More

    Influence of topical steroids on intraocular pressure in patients with atopic dermatitis.
    Allergol Int 2018 Feb 15. Epub 2018 Feb 15.
    Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
    Background: Topical corticosteroids (TCS) can induce adverse effects, such as skin atrophy. Although TCS can cause increases in intraocular pressure (IOP), the effects of daily TCS use on IOP have not been fully elucidated. We evaluated the clinical doses of TCS and the change in the IOP during the daily treatment of atopic dermatitis (AD). Read More

    The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice.
    Allergol Int 2018 Feb 10. Epub 2018 Feb 10.
    Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. Electronic address:
    Background: Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sensitization is needed. However, a fundamental problem in that regard is that the optimal age for epicutaneous sensitization of mice is unknown. Read More

    Definition and diagnosis of asthma-COPD overlap (ACO).
    Allergol Int 2018 Apr 9;67(2):172-178. Epub 2018 Feb 9.
    Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
    It is now widely recognized that asthma and COPD can coexist as asthma-COPD overlap (ACO), but the preliminary attempts at providing universal guidelines for the diagnosis of ACO still need to be improved. We believe that a case can be made for devising guidelines for the diagnosis of this increasingly common disease that are specific to Japan. In this paper, we present our consensus-based description of ACO which we believe is realistic for use in our country. Read More

    Long-term management and persistent impairment of pulmonary function in chronic eosinophilic pneumonia: A review of the previous literature.
    Allergol Int 2018 Jan 23. Epub 2018 Jan 23.
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Chronic eosinophilic pneumonia (CEP) is an inflammatory disease characterized by accumulations of eosinophils in the lung with unknown etiology. Although corticosteroid treatment dramatically resolves these inflammations, relapse is common during the course of the disease. Approximately 50% of patients with CEP experience relapse. Read More

    Efficacy and safety of emedastine patch, a novel transdermal drug delivery system for allergic rhinitis: Phase III, multicenter, randomized, double-blinded, placebo-controlled, parallel-group comparative study in patients with seasonal allergic rhinitis.
    Allergol Int 2018 Jan 29. Epub 2018 Jan 29.
    Hisamitsu Pharmaceutical Co., Inc., Tokyo, Japan.
    Background: Emedastine patch was developed in Japan as the first transdermal drug delivery system of emedastine difumarate for allergic rhinitis.

    Methods: A multicenter, randomized, double-blind, placebo-controlled, parallel-group comparison was conducted in patients with seasonal allergic rhinitis. Patients were administered emedastine patches (4 or 8 mg), placebo, or levocetirizine hydrochloride (5 mg tablet) once daily for 2 weeks (double-dummy technique). Read More

    ETosis-derived DNA trap production in middle ear effusion is a common feature of eosinophilic otitis media.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan.

    Recent advances in understanding the roles of blood platelets in the pathogenesis of allergic inflammation and bronchial asthma.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, Tokyo, Japan. Electronic address:
    Platelets play an essential role in hemostasis to minimize blood loss due to traumatic injury. In addition, they contain various immune-associated molecules and contribute to immunological barrier formation at sites of vascular injury, thereby protecting against invading pathogens. Platelets are also crucially involved in development of allergic diseases, including bronchial asthma. Read More

    Increased ratio of pollock roe-specific IgE to salmon roe-specific IgE levels is associated with a positive reaction to cooked pollock roe oral food challenge.
    Allergol Int 2017 Dec 11. Epub 2017 Dec 11.
    Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan. Electronic address:
    Background: Anaphylaxis and immediate-type fish roe allergies have been reported worldwide, and, in Japan, fish roe is the sixth most common food allergen. No oral food challenges (OFCs) have used pollock roe (PR), which is reported to have high cross-reactivity with salmon roe (SR). Therefore, we administered an OFC using cooked PR to evaluate PR- and SR-specific immunoglobulin E (IgE) levels and allergic reactions in patients with PR sensitivity. Read More

    Recent advancement to prevent the development of allergy and allergic diseases and therapeutic strategy in the perspective of barrier dysfunction.
    Allergol Int 2018 Jan 7;67(1):24-31. Epub 2017 Dec 7.
    Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address:
    Therapeutic strategy in late 20th century to prevent allergic diseases was derived from a conceptual framework of allergens elimination which was as same as that of coping with them after their onset. Manifold trials were implemented; however, most of them failed to verify the effectiveness of their preventive measures. Recent advancement of epidemiological studies and cutaneous biology revealed epidermal barrier dysfunction plays a major role of allergen sensitization and development of atopic dermatitis which ignites the inception of allergy march. Read More

    Long-term safety of subcutaneous immunotherapy with TO-204 in Japanese patients with house dust mite-induced allergic rhinitis and allergic bronchial asthma: Multicenter, open label clinical trial.
    Allergol Int 2017 Dec 7. Epub 2017 Dec 7.
    Department of Clinical Development, Torii Pharmaceutical Co., Ltd., Tokyo, Japan.
    Background: To evaluate the long-term safety of subcutaneous immunotherapy with TO-204, a standardized house dust mite (HDM) allergen extracts, we conducted a multicenter, open label clinical trial.

    Methods: Japanese patients aged 5-65 years were eligible for the study, if they had HDM-induced allergic rhinitis (AR), allergic bronchial asthma (BA), or both. TO-204 was administered in a dose titration scheme, and the maintenance dose was determined according to the predefined criteria. Read More

    Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects.
    Allergol Int 2017 Dec 6. Epub 2017 Dec 6.
    Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
    Background: Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. Read More

    Th1-related disease development during omalizumab treatment: Two cases with severe asthma.
    Allergol Int 2017 Nov 27. Epub 2017 Nov 27.
    Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan. Electronic address:

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