1,112 results match your criteria Allergology International[Journal]


The Urticaria Control Test and Urticaria Activity Score correlate with quality of life in adult Japanese patients with chronic spontaneous urticaria.

Allergol Int 2018 Dec 4. Epub 2018 Dec 4.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183015
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.11.003DOI Listing
December 2018
4 Reads

Bird-egg syndrome induced by α-livetin sensitization in a budgerigar keeper: Successful induction of tolerance by avoiding exposure to avians.

Allergol Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.11.004DOI Listing
December 2018

Obesity and severe asthma.

Allergol Int 2018 Nov 30. Epub 2018 Nov 30.

Department of Environmental Health, Harvard University T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

Obesity is an important global health issue for both children and adults. Obesity increases the prevalence and incidence of asthma and also increases the risk for severe asthma. Here we describe the features of severe asthma phenotypes for which obesity is a defining characteristic, including steroid resistance, airway inflammation, and co-morbidities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.10.004DOI Listing
November 2018

Airway innate lymphoid cells in the induction and regulation of allergy.

Allergol Int 2018 Nov 22. Epub 2018 Nov 22.

Department of Medicine, University of California, San Diego, CA, USA. Electronic address:

The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). ILCs are divided into group 1 (ILC1s), group 2 (ILC2s), or group 3 (ILC3s). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.11.001DOI Listing
November 2018
1 Read

Obesity, but not metabolic syndrome, as a risk factor for late-onset asthma in Japanese women.

Allergol Int 2018 Nov 22. Epub 2018 Nov 22.

Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan.

Background: Several cross-sectional studies have suggested an association between obesity and asthma. However, few studies have investigated this relationship longitudinally, especially in middle-aged subjects. Although metabolic syndrome is a well-known risk factor for many non-communicable diseases, its contribution to asthma remains controversial. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183015
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.10.003DOI Listing
November 2018
4 Reads

Critical role of platelets in the production of thymus and activation-regulated chemokine in children: A case series study.

Allergol Int 2018 Nov 20. Epub 2018 Nov 20.

Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.11.002DOI Listing
November 2018

Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation.

Allergol Int 2018 Nov 10. Epub 2018 Nov 10.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

Asthma is the most prevalent allergic disease of the airway, which is characterized by eosinophilic inflammation, mucus hyperproduction, and airway hyper-responsiveness. Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. IL-22, one of the cytokines produced by Th17 cells and type 3 ILCs, has distinct functional properties, as IL-22 exclusively acts on non-hematopoietic cells including epithelial cells of mucosal surface and exhibits a broad range of action in regeneration and host protection. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.10.002DOI Listing
November 2018
5 Reads

Periostin deletion suppresses late-phase response in mouse experimental allergic conjunctivitis.

Allergol Int 2018 Nov 9. Epub 2018 Nov 9.

Laboratory of Ocular Atopic Diseases, Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address:

Background: To investigate the potential roles of periostin (POSTN), an extracellular matrix preferentially expressed in Th2-skewed conditions in the pathophysiology of allergic conjunctivitis.

Methods: The roles of POSTN in ragweed-induced experimental allergic conjunctivitis (RW-EAC) were evaluated using both POSTN-knockout (KO) and congenic BALB/c wild-type mice. Histological analysis was carried out to enumerate eosinophils/basophils in the conjunctival tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.09.007DOI Listing
November 2018
1 Read

Efficacy and safety of rupatadine in Japanese patients with seasonal allergic rhinitis: A double-blind, randomized, multicenter, placebo-controlled clinical trial.

Allergol Int 2018 Oct 31. Epub 2018 Oct 31.

Teikoku Seiyaku Co., Ltd., Kagawa, Japan.

Background: Rupatadine is a novel non-sedating second-generation H-antihistamine with antiplatelet-activating factor activity, first marketed in Spain in 2003. It is used for treating allergic rhinitis in more than 80 countries. This study investigated its efficacy and safety in Japanese patients with seasonal allergic rhinitis (SAR). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.011DOI Listing
October 2018
1 Read

A comprehensive understanding of the gut mucosal immune system in allergic inflammation.

Allergol Int 2018 Oct 23. Epub 2018 Oct 23.

Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California San Diego, San Diego, CA, USA; Division of Comparative Pathology and Medicine, Department of Pathology, University of California San Diego, San Diego, CA, USA. Electronic address:

Despite its direct exposure to huge amounts of microorganisms and foreign and dietary antigens, the gut mucosa maintains intestinal homeostasis by utilizing the mucosal immune system. The gut mucosal immune system protects the host from the invasion of infectious pathogens and eliminates harmful non-self antigens, but it allows the cohabitation of commensal bacteria in the gut and the entry of dietary non-self antigens into the body via the mucosal surface. These physiological and immunological activities are regulated by the ingenious gut mucosal immune network, comprising such features as gut-associated lymphoid tissue, mucosal immune cells, cytokines, chemokines, antimicrobial peptides, secretory IgA, and commensal bacteria. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.09.004DOI Listing
October 2018
10 Reads

Identification of biomarkers for predicting the response to cyclosporine A therapy in patients with chronic spontaneous urticaria.

Allergol Int 2018 Oct 22. Epub 2018 Oct 22.

Allergy and Immunology Research Project Team, Research Institute of Medical Science, Nihon University School of Medicine, Tokyo, Japan; Center for Institutional Research and Medical Education, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.09.006DOI Listing
October 2018
1 Read

Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis.

Allergol Int 2018 Oct 19. Epub 2018 Oct 19.

Division of Otorhinolaryngology Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, Japan.

Background: In Eosinophilic chronic rhinosinusitis (ECRS), it is difficult to estimate the refractoriness and recurrence risk for each patient. Fraction of exhaled nitric oxide (FeNO) is known as a biomarker of eosinophilic inflammation in lower airway. It has been reported that nasal NO has some crucial functions in the upper and lower airways. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183014
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.09.005DOI Listing
October 2018
2 Reads

SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases.

Allergol Int 2018 Oct 17. Epub 2018 Oct 17.

Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka, Japan; Integrated Frontier Research for Medical Science Division, The Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.10.001DOI Listing
October 2018
1 Read

Efficacy of a short pretreatment with omalizumab in children with anaphylaxis to hymenoptera venom immunotherapy: A report of three cases.

Allergol Int 2018 Oct 17. Epub 2018 Oct 17.

AP-HP, Hôpital Necker-Enfants Malades, Service de Pneumologie et d'Allergologie Pédiatriques, Paris, France; Université Paris Descartes, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.09.003DOI Listing
October 2018
1 Read

Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis.

Allergol Int 2018 Oct 10. Epub 2018 Oct 10.

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan. Electronic address:

Background: IgG4 production is regulated by type 2 (IL-4 and IL-13) and regulatory (IL-10) cytokines involved in the pathophysiology of chronic rhinosinusitis (CRS). We sought to determine the pathophysiological characteristics of IgG4-positive cells in sinonasal tissues in CRS, especially eosinophilic CRS (ECRS).

Methods: IgG4-positive cells in uncinate tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183013
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.09.002DOI Listing
October 2018
6 Reads

Accuracy of objective tests for diagnosing adult asthma in symptomatic patients: A systematic literature review and hierarchical Bayesian latent-class meta-analysis.

Allergol Int 2018 Oct 8. Epub 2018 Oct 8.

Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, Osaka, Japan.

Background: We obtain summary estimates of the accuracy of additional objective tests for the diagnosis of adult asthma using systematic review and meta-analysis of diagnostic test accuracy studies.

Methods: Medline, Embase, and other relevant electronic databases were searched for papers published between January 1989 and December 2016. Studies were included if they evaluated the diagnostic accuracy of objective tests, including airway reversibility (AR), airway hyperresponsiveness (AHR), and fractionated exhaled nitric oxide (FeNO) for the diagnosis of adult asthma in patients with symptoms suggestive of asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.013DOI Listing
October 2018

Usefulness of serum biopterin as a predictive biomarker for childhood asthma control: A prospective cohort study.

Allergol Int 2018 Oct 5. Epub 2018 Oct 5.

Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.

Methods: We conducted a single-center prospective cohort study involving 168 asthmatic children aged 4-17 years who visited the periodical asthma checkup program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.012DOI Listing
October 2018
1 Read

Two facets of sweat: A defensive factor in skin tissues and an accelerating factor for allergic skin diseases.

Allergol Int 2018 Oct;67(4):433-434

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.09.001DOI Listing
October 2018

Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants.

Allergol Int 2018 Sep 22. Epub 2018 Sep 22.

Department of Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan.

Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations.

Methods: Grading scales of the severity of non-IgE-GI-FAs according to extra-GI symptoms, such as poor weight gain, as well as systemic symptoms, including fever and shock, were developed and retrospectively applied to patients with non-IgE-GI-FAs. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183010
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.08.004DOI Listing
September 2018
22 Reads

Ultrasonographic study of intestinal Doppler blood flow in infantile non-IgE-mediated gastrointestinal food allergy.

Allergol Int 2018 Sep 22. Epub 2018 Sep 22.

Department of Pediatrics and Adolescent Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Background: Although non-IgE-mediated gastrointestinal food allergy has increased rapidly in Japan, a small number of reports has evaluated B-mode and Doppler ultrasonographic findings in the acute phase of infantile gastrointestinal milk allergy. The aim of the present study was to compare the diagnostic utility of ultrasonographic findings and laboratory allergic data in non-IgE-mediated infantile gastrointestinal milk allergy.

Methods: Sixteen cases of active non-IgE-mediated infantile gastrointestinal milk allergy, diagnosed by food elimination tests and oral food challenge tests (OFCTs) (group A), 15 cases of acute viral gastroenteritis (AGE) (group B), and 15 controls (group C) were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.010DOI Listing
September 2018
2 Reads

Factors determining parenting stress in mothers of children with atopic dermatitis.

Allergol Int 2018 Sep 11. Epub 2018 Sep 11.

Department of Nursing, Health Development Nursing, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Atopic dermatitis (AD) influences a child's emotional and social well-being, as well as his or her physical health. The influence of AD on the daily lives of parents and caregivers has also been documented. This study examined how parenting stress is affected by demographic background, characteristics of children's AD, and their family systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.006DOI Listing
September 2018
1 Read

Characteristics of breath sound in infants with risk factors for asthma development.

Allergol Int 2018 Sep 10. Epub 2018 Sep 10.

Department of Pediatrics, Tokai University School of Medicine, Kanagawa, Japan.

Background: Breath sound parameters have been suggested as biomarkers of the airway narrowing in children. Using a commercially available breath sound analyzer, the characteristics of the airway condition were investigated in infants with the risk factors for asthma development.

Methods: A total of 443 infants (mean age, 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.011DOI Listing
September 2018
9 Reads

CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts.

Allergol Int 2018 Sep 6. Epub 2018 Sep 6.

Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Bronchial asthma is a chronic airway disease characterized by eosinophilic airway inflammation. Lung fibroblasts activated by IL-13 serve as important sources of chemokines, such as eotaxins, contributing to persistent eosinophilic inflammation. Src-homology 2-containing protein (CISH), belonging to the suppressor of cytokine signaling (SOCS) family, acts as a negative regulator of cytokine induction. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183010
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.08.005DOI Listing
September 2018
8 Reads

Preface to the proceedings of the Workshop on Eosinophils in Allergy and Related Diseases 2017.

Authors:
Hiroshi Nakajima

Allergol Int 2018 09;67S:S1-S2

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.007DOI Listing
September 2018

Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test.

Allergol Int 2018 Sep 3. Epub 2018 Sep 3.

Department of Pediatrics, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.001DOI Listing
September 2018
2 Reads

A case of human seminal plasma allergy sensitized with dog prostatic kallikrein, Can f 5.

Allergol Int 2018 Sep 1. Epub 2018 Sep 1.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.003DOI Listing
September 2018

Sweat is a most efficient natural moisturizer providing protective immunity at points of allergen entry.

Allergol Int 2018 Oct 1;67(4):442-447. Epub 2018 Sep 1.

Department of Dermatology, Kawasaki Medical School, Kurashiki, Japan; Dermatology, Kawasaki Hospital, Okayama, Japan.

Although there is a growing acceptance that sweat could play a detrimental role in various allergic skin diseases, the possibility that sweat is also involved in maintenance of skin hydration and skin-specific immune responses has not been acknowledged. We initially describe physiological role of sweat in both maintaining skin hydration and thermoregulation. The purpose of this article is to provide the reader with objective evidence that sweating is intimately linked to vital stratum corneum barrier function and usefulness of application of moisturizers in clinical care of allergic skin diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.010DOI Listing
October 2018

Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis.

Allergol Int 2018 Aug 27. Epub 2018 Aug 27.

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan. Electronic address:

Background: The development of methods to predict the clinical effectiveness of sublingual immunotherapy (SLIT) for allergic diseases is a crucial matter. We sought to determine whether whole saliva, which is the first body component that contacts allergen extracts during SLIT, is associated with the clinical effectiveness of SLIT in Japanese cedar pollinosis.

Methods: Blood monocytes or monocytic THP-1 cells were cultured in the presence or absence of either whole saliva or pure saliva with or without treatments including filtration and blockade of TLR2 and/or TLR4 signaling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.008DOI Listing
August 2018
6 Reads

Central suppressant therapies in unexplained chronic cough patients whose sputum cultures yielded Bjerkandera adusta.

Allergol Int 2018 Aug 23. Epub 2018 Aug 23.

Laboratory of Space and Environmental Medicine, Teikyo University, Tokyo, Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13238930183009
Publisher Site
http://dx.doi.org/10.1016/j.alit.2018.07.009DOI Listing
August 2018
6 Reads

Immediate anaphylaxis due to beef intestine following tick bites.

Allergol Int 2018 Aug 23. Epub 2018 Aug 23.

Department of Pediatrics, National Hospital Organization Fukuyama Medical Center, Fukuyama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.08.002DOI Listing
August 2018
2 Reads

Geographic and demographic variations of inhalant allergen sensitization in Koreans and non-Koreans.

Allergol Int 2018 Aug 10. Epub 2018 Aug 10.

Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea; The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea; Korea Mouse Sensory Phenotyping Center, Seoul, South Korea; Medical Research Center, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Background: To diagnose and treat respiratory allergic diseases, it is important to identify the specific allergens involved. Many differences exist between common inhalant allergens depending on the residential environment and demographic factors. This study aimed to compare common inhalant allergens between Koreans and non-Koreans according to their residential region, age, and sex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.005DOI Listing
August 2018
1 Read

Dry skin manifestations in Sjögren syndrome and atopic dermatitis related to aberrant sudomotor function in inflammatory allergic skin diseases.

Authors:
Ichiro Katayama

Allergol Int 2018 Oct 10;67(4):448-454. Epub 2018 Aug 10.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita-shi, Osaka 565-0871, Japan. Electronic address:

We have reported characteristic cutaneous manifestations of Sjögren syndrome (SS) with special references to autoimmune anhidrosis or hypoidrosis and related mucocutaenous manifestations in addition to annular erythema or cutaneous vasculitis. Although significance of cutaneous manifestations of SS has been gradually recognized in rheumatologists, sudomotor function has not been fully evaluated and recognized in the diagnosis of SS except for dermatologists. SS is a relatively underestimated collagen disease in contrast to SLE, systemic sclerosis, or dermatomyositis, special care should be needed not to make misdiagnosis of SS when we see the patients with common skin disease such as, drug eruption, infections skin disease or xerosis in the daily practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.001DOI Listing
October 2018
2 Reads

Mal d 1 and Bet v 1 sensitization pattern in children with Pollen Food Syndrome.

Allergol Int 2018 Aug 9. Epub 2018 Aug 9.

Ospedale Policlinico San Martino, Genoa, Italy. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.006DOI Listing
August 2018
3 Reads

Mast cell activation syndrome: High frequency of skin manifestations and anaphylactic shock.

Allergol Int 2018 Aug 7. Epub 2018 Aug 7.

Mastocytosis National Reference Center (CEREMAST), Department of Dermatology, Toulouse University Hospital, Paul Sabatier University, Toulouse, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.003DOI Listing
August 2018
10 Reads

Association analyses of eQTLs of the TYRO3 gene and allergic diseases in Japanese populations.

Allergol Int 2018 Aug 3. Epub 2018 Aug 3.

Department of Pulmonary Medicine, University of Tsukuba, Tsukuba, Japan.

Background: TYRO3 is a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family and functions to limit type 2 immune responses implicated in allergic sensitization. Recent studies have shown that multiple intronic variants of TYRO3 were associated with asthma, implying that genetic variation could contribute to errant immune activation. We therefore hypothesized that expression quantitative trait loci (eQTLs) of the TYRO3 gene influence the development of allergic diseases (including asthma and allergic rhinitis) in Japanese populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.004DOI Listing
August 2018
6 Reads

Sweat in the pathogenesis of atopic dermatitis.

Allergol Int 2018 Oct 3;67(4):455-459. Epub 2018 Aug 3.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

Sweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.06.003DOI Listing
October 2018
3 Reads

Sweat allergy.

Allergol Int 2018 Oct 31;67(4):435-441. Epub 2018 Jul 31.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

Sweat allergy is defined as a type I hypersensitivity against the contents of sweat, and is specifically observed in patients with atopic dermatitis (AD) and cholinergic urticaria (CholU). The allergic reaction is clinically revealed by positive reactions in the intradermal skin test and the basophil histamine release assay by sweat. A major histamine-releasing antigen in sweat, MGL_1304, has been identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.07.002DOI Listing
October 2018
4 Reads

Efficacy and safety of rupatadine in Japanese adult and adolescent patients with chronic spontaneous urticaria: A double-blind, randomized, multicenter, placebo-controlled clinical trial.

Allergol Int 2018 Jul 17. Epub 2018 Jul 17.

Teikoku Seiyaku Co., Ltd., Kagawa, Japan.

Background: Rupatadine, a novel nonsedating second-generation H1-antihistamine with antiplatelet-activating factor activity, has been used in the treatment of allergic rhinitis and urticaria in European countries since 2003. However, its efficacy and safety in Japanese patients with chronic spontaneous urticaria (CSU) are unknown.

Methods: We conducted a prospective, multicenter, randomized, placebo-controlled, double-blind study in adolescent and adult CSU outpatients aged 12 to < 65 years (JAPIC-CTI No. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.06.002DOI Listing
July 2018
3 Reads

Darier's sign in urticaria pigmentosa-significance of perivascular eosinophilic infiltration.

Allergol Int 2018 Oct 11;67(4):532-534. Epub 2018 Jul 11.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.04.006DOI Listing
October 2018
2 Reads

Three cases of adult-onset atopic dermatitis after hematopoietic stem cell transplantation.

Allergol Int 2018 Oct 11;67(4):529-531. Epub 2018 Jul 11.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.04.002DOI Listing
October 2018
3 Reads

The status of sublingual immunotherapy in the treatment of allergic diseases.

Allergol Int 2018 Jul;67(3):299-300

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.06.001DOI Listing
July 2018
5 Reads

Natural course of new-onset urticaria: Results of a 10-year follow-up, nationwide, population-based study.

Allergol Int 2018 Jun 23. Epub 2018 Jun 23.

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, South Korea. Electronic address:

Background: Previous epidemiologic studies of the natural course of urticaria mainly focused on chronic spontaneous urticaria and were conducted at hospitals. The natural course of new-onset urticaria in the general population is unknown.

Methods: Patients with new-onset urticaria were identified from the National Health Insurance Service-National Sample Cohort data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.011DOI Listing
June 2018
5 Reads

Soluble ST2 suppresses IL-5 production by human basophilic KU812 cells, induced by epithelial cell-derived IL-33.

Allergol Int 2018 Sep 22;67S:S32-S37. Epub 2018 Jun 22.

Department of Otorhinolaryngology, Shiga University of Medical Science, Shiga, Japan.

Background: Epithelial cell-derived IL-33 has an important role in the initiation and activation of innate allergic inflammation. IL-33 acts as a cytokine through the ST2 receptor (ST2L) and it stimulates the production of Th2 cytokines. Soluble ST2 (sST2) may regulate Th2 responses by neutralizing the activity of IL-33. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.009DOI Listing
September 2018
3 Reads

Examination of the cut-off values for a questionnaire used to evaluate asthma control in Japanese asthma patients.

Allergol Int 2018 Jun 18. Epub 2018 Jun 18.

NPO Sapporo Cough Asthma and Allergy Center, Sapporo, Japan.

Background: The Japan Asthma Control Survey (JACS) questionnaire, developed as a tool for measuring asthma control levels in Japanese asthma patients, was previously tested for its reliability and validity. However, many of the patients enrolled in the original validation study had mild asthma; thus a re-evaluation including severe cases was required to calculate more reliable cut-off values.

Methods: Pooled analysis of data from the original validation study and the subsequent medication guidance study including adult patients with severe asthma was conducted to calculate the JACS questionnaire cut-off values and to assess their sensitivity and specificity for identifying "well-controlled", "not well-controlled", and "poorly controlled" asthma as described in the Asthma Prevention and Management Guideline 2015 (JGL2015). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.007DOI Listing
June 2018
4 Reads

Pediatric case with rice bran allergy induced by epicutaneous sensitization in a family rice shop.

Allergol Int 2018 Jun 16. Epub 2018 Jun 16.

Department of Dermatology, Yokohama City University School of Medicine, Yokohama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.010DOI Listing
June 2018
2 Reads

Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis.

Allergol Int 2018 Sep 15;67S:S25-S31. Epub 2018 Jun 15.

Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Background: We have recently demonstrated that T cell-mediated nasal hyperresponsiveness (NHR) is a representative pathophysiological feature of allergic rhinitis (AR). Although several anti-allergic drugs are used for the treatment of AR, the efficacy of these drugs on T cell-mediated NHR have not been elucidated. In these studies we investigated the effects of dexamethasone (Dex), montelukast (Mk), and chlorpheniramine (Chl) on NHR in antigen-immunized and antigen-specific Th2 cell-transferred mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.002DOI Listing
September 2018
7 Reads

Analysis of factors associated with cedar pollen sensitization and development of pollinosis in a young Japanese adult population.

Allergol Int 2018 Jun 13. Epub 2018 Jun 13.

Department of Otorhinolaryngology, Head & Neck Surgery, Mie University Graduate School of Medicine, Mie, Japan. Electronic address:

Background: Genetic and environmental factors are proposed to be involved in cedar pollen allergy sensitization and onset. The impact of these factors will provide key information for the prevention of cedar pollen sensitization and allergy onset, which we investigated in this cross-sectional study.

Methods: Subjects were 382 young adult volunteers who completed a self-administered questionnaire on self-reported subjective symptoms of pollinosis, physician-diagnosed pollinosis, and background factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.006DOI Listing
June 2018
3 Reads

Analyses of dermal innate lymphoid cells in mice lacking T-bet and STAT6.

Allergol Int 2018 Sep 11;67S:S51-S53. Epub 2018 Jun 11.

Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2018.05.004DOI Listing
September 2018
3 Reads