1,271 results match your criteria Allergology International[Journal]


Dietary patterns and allergy in children aged 5-12 years in Australia: Findings from the mothers and their Children's health study.

Allergol Int 2020 May 23. Epub 2020 May 23.

Centre for Longitudinal and Life Course Research, University of Queensland, School of Public Health, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.04.012DOI Listing

Two cases of angioedema without wheals induced by exercising or bathing.

Allergol Int 2020 May 22. Epub 2020 May 22.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.04.011DOI Listing

Slow low-dose oral immunotherapy: Threshold and immunological change.

Allergol Int 2020 May 19. Epub 2020 May 19.

Department of Allergy, Aichi Children's Health and Medical Center, Obu, Japan.

Background: We examined the feasibility, efficacy and safety of slow low-dose oral immunotherapy (SLOIT) for egg, milk, wheat allergies, with accepted severity-stratified initial and maintenance doses.

Methods: Children with food allergies defined by low-dose oral food challenges (LD-OFCs) to hen's egg (cumulative protein dose up to 983 mg, n = 133), cow's milk (287 mg, n = 50), and wheat (226 mg, n = 45) were recruited. Participants were divided into two groups [SLOIT and control (complete avoidance]) based on their preferences. Read More

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http://dx.doi.org/10.1016/j.alit.2020.03.008DOI Listing

ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization.

Allergol Int 2020 May 19. Epub 2020 May 19.

Department of Pulmonary Medicine, University of Tsukuba, Tsukuba, Japan.

Background: An orosomucoid-like 3 (ORMDL3)/gasdermin B (GSDMB) gene locus on chromosome 17q is consistently associated with childhood-onset asthma, which is highly atopic. As some evidence suggests the relationship between asthma and allergic sensitization reflects asthma patient susceptibility to augmented IgE responses driven by common environmental allergens rather than an increased asthma risk after allergen exposure, we aimed to determine any relationships between this locus region and childhood-onset adult asthma with regard to serum total IgE levels or allergic sensitization.

Methods: We conducted a case-control association study using three independent Japanese populations (3869 total adults) and analyzed the ORs for association of rs7216389, an expression quantitative trait locus for ORMDL3/GSDMB, with adult asthma according to onset age. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.009DOI Listing

The prevalence of oral symptoms caused by Rosaceae fruits and soybean consumption in children; a Japanese population-based survey.

Allergol Int 2020 May 19. Epub 2020 May 19.

Division of Allergy, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

Background: Pollen food Syndrome (PFS) to Rosaceae fruits and soybean, related to Bet v 1 homologue sensitization has been reported increasingly throughout Japan, possibly due to the wide distribution of alder.

Methods: In 2015, we conducted a school-based questionnaire survey among two age groups; students in primary school (Years 1-2) and secondary school (Years 8-9) from each of the 47 prefectures of Japan. We analyzed the prevalence, demographic and clinical characteristics of children with oral symptoms to Rosaceae fruits/soybean; defined as oral symptoms occurring shortly after ingesting apple, peach, cherry or soybean. Read More

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http://dx.doi.org/10.1016/j.alit.2020.03.011DOI Listing

Dupilumab efficacy and safety in Japanese patients with uncontrolled, moderate-to-severe asthma in the phase 3 LIBERTY ASTHMA QUEST study.

Allergol Int 2020 May 19. Epub 2020 May 19.

Sanofi, Bridgewater, NJ, USA.

Background: In the LIBERTY ASTHMA QUEST (ClinicalTrials.gov: NCT02414854) study, dupilumab 200 mg and 300 mg every 2 weeks vs matched-volume placebo reduced severe asthma exacerbations and improved lung function (FEV), asthma control, and quality of life in patients with uncontrolled, moderate-to-severe asthma (N = 1902). Here, we examine the safety and efficacy of dupilumab in the subpopulation of Japanese patients who participated in QUEST (n = 114; 6%). Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.002DOI Listing

High prevalence of epilepsy in HAE with normal C1-INH.

Allergol Int 2020 May 19. Epub 2020 May 19.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.04.008DOI Listing

Thymus and activation-regulated chemokine (TARC/CCL17) predicts decline of pulmonary function in patients with chronic obstructive pulmonary disease.

Allergol Int 2020 May 19. Epub 2020 May 19.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University Faculty of Medicine, Yamagata, Japan.

Background: The deterioration of pulmonary function, such as FEV-decline, is strongly associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, few investigations shed light on useful biomarkers for predicting the decline of pulmonary function. We evaluated whether thymus and activation-regulated chemokine (TARC), a Th2 inflammation marker, could predict rapid FEV-decline in COPD patients. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.004DOI Listing

A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure.

Allergol Int 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.04.007DOI Listing

The impact of mepolizumab on the sputum level of eosinophil-derived protein in three cases of severe asthma.

Allergol Int 2020 May 18. Epub 2020 May 18.

Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.03.009DOI Listing

The impact of budesonide inhalation suspension for asthma hospitalization: In terms of length of stay, recovery time from symptoms, and hospitalization costs.

Allergol Int 2020 May 13. Epub 2020 May 13.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: Hospitalization is a major cause of medical expenditure for asthma. Budesonide inhalation suspension (BIS) may assist in reducing asthma-related symptoms in severe asthma exacerbation. However, its effectiveness for hospitalized patients remains poorly known. Read More

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http://dx.doi.org/10.1016/j.alit.2020.04.003DOI Listing

Cough persistence in adults with chronic cough: A 4-year retrospective cohort study.

Allergol Int 2020 Apr 20. Epub 2020 Apr 20.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Background: There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence.

Methods: A retrospective cohort was constructed of adults who had newly visited a specialist cough clinic in 2012-2013. Read More

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http://dx.doi.org/10.1016/j.alit.2020.03.012DOI Listing

Investigating Japanese cedar pollen-induced allergic rhinitis and related terms using Google Trends.

Allergol Int 2020 Apr 7. Epub 2020 Apr 7.

Department of Otorhinolaryngology, Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.03.006DOI Listing

Focal eosinophilic myositis with Charcot-Leyden crystal formation.

Allergol Int 2020 Apr 7. Epub 2020 Apr 7.

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.03.007DOI Listing

Japanese guidelines for atopic dermatitis 2020.

Allergol Int 2020 Apr 4. Epub 2020 Apr 4.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Atopic dermatitis (AD) is a disease characterized by relapsing eczema with pruritus as a primary lesion, which is frequently encountered in clinical practice. Skin barrier dysfunction leads to enhanced skin irritability to non-specific stimuli and epicutaneous sensitization. In the lesion site, a further inflammation-related reduction in skin barrier function, enhanced irritability and scratching-related stimuli deteriorate eczema, leading to vicious cycle of inflammation. Read More

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http://dx.doi.org/10.1016/j.alit.2020.02.006DOI Listing

Epinephrine autoinjector prescription patterns for severe anaphylactic patients in Japan: A retrospective analysis of health insurance claims data.

Allergol Int 2020 Apr 3. Epub 2020 Apr 3.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Background: Current guidelines recommend that any patient who has experienced anaphylaxis should be prescribed one or more epinephrine autoinjectors (EAI) for immediate self-treatment. However, the etiology of anaphylaxis and prescription patterns of EAI have not been widely examined in Japan.

Methods: This was a retrospective cohort study using a large Japanese claims database (JMDC, Tokyo, Japan). Read More

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http://dx.doi.org/10.1016/j.alit.2020.02.008DOI Listing

Rapid clearance of mepolizumab-resistant bronchial mucus plugs in allergic bronchopulmonary aspergillosis with benralizumab treatment.

Allergol Int 2020 Apr 1. Epub 2020 Apr 1.

Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Isehara, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.03.003DOI Listing

A case of hen's egg-dependent exercise-induced immediate-type allergy.

Allergol Int 2020 Mar 30. Epub 2020 Mar 30.

Department of Allergology, Fujita Health University School of Medicine, Nagoya, Japan; Fujita Health University General Allergy Center in Bantane Hospital, Nagoya, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.01.006DOI Listing

The start of a new era of biologics for treating allergic diseases.

Authors:
Kenji Izuhara

Allergol Int 2020 Apr;69(2):165-166

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.03.002DOI Listing

Dupilumab therapy rapidly improved alopecia areata associated with trichotillomania in an atopic dermatitis patient.

Allergol Int 2020 Mar 28. Epub 2020 Mar 28.

Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.02.009DOI Listing

Early benralizumab for eosinophilic myocarditis in eosinophilic granulomatosis with polyangiitis.

Allergol Int 2020 Mar 26. Epub 2020 Mar 26.

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2020.03.001DOI Listing

Three cases of diffuse panbronchiolitis in children with a past history of difficult-to-treat bronchial asthma: A case report from a single medical facility.

Allergol Int 2020 Mar 23. Epub 2020 Mar 23.

Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan; Department of Pediatrics, Tokyo Jikei University Daisan Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.02.007DOI Listing

An asthmatic case of psoriasiform eruption caused by administration of dupilumab.

Allergol Int 2020 Mar 13. Epub 2020 Mar 13.

Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.02.004DOI Listing

The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis.

Allergol Int 2020 Apr 2;69(2):178-186. Epub 2020 Mar 2.

Division of Otorhinolaryngology - Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan. Electronic address:

IL-5 is the most potent activator of eosinophils and is produced by Th2 cells and ILC2s. A role for IL-5 in eosinophil extracellular trap cell death, i.e. Read More

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http://dx.doi.org/10.1016/j.alit.2020.02.002DOI Listing

Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests in patients with bronchial asthma.

Allergol Int 2020 Feb 26. Epub 2020 Feb 26.

Department of Respiratory Medicine and Allergology, Kindai University, Faculty of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.12.005DOI Listing
February 2020

Stratum corneum interleukin-25 expressions correlate with the degree of dry skin and acute lesions in atopic dermatitis.

Allergol Int 2020 Feb 24. Epub 2020 Feb 24.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.alit.2020.02.001DOI Listing
February 2020

Roles of omalizumab in various allergic diseases.

Allergol Int 2020 Apr 14;69(2):167-177. Epub 2020 Feb 14.

Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan. Electronic address:

IgE and mast cells play a pivotal role in various allergic diseases, including asthma, allergic rhinitis, and urticaria. Treatment with omalizumab, a monoclonal anti-IgE antibody, has significantly improved control of these allergic diseases and introduced a new era for the management of severe allergic conditions. About 10 years of experience with omalizumab treatment for severe allergic asthma confirmed its effectiveness and safety, reducing symptoms, frequency of reliever use, and severe exacerbations in patients with intractable conditions. Read More

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http://dx.doi.org/10.1016/j.alit.2020.01.004DOI Listing

Implications of IL-13Rα2 in atopic skin inflammation.

Allergol Int 2020 Feb 6. Epub 2020 Feb 6.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Atopic dermatitis (AD) is a common eczematous skin disorder characterized by skin inflammation, barrier disruption, chronic pruritus and marked scratching. Th2 cytokines, especially IL-13, play a pathogenic role in AD. IL-13 signals via a heterodimeric receptor composed of IL-4Rα and IL-13 Rα1. Read More

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http://dx.doi.org/10.1016/j.alit.2020.01.005DOI Listing
February 2020

Dupilumab: Basic aspects and applications to allergic diseases.

Allergol Int 2020 Apr 30;69(2):187-196. Epub 2020 Jan 30.

Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, Ube, Japan.

Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding to two types of receptors sharing the IL-4R α chain (IL-4Rα). Since IL-4 and IL-13 play important and redundant roles in the pathogenesis of allergic diseases, blocking both the IL-4 and IL-13 signals would be a powerful and effective strategy for treating allergic diseases. Dupilumab (Dupixent®) is a fully human monoclonal antibody recognizing IL-4Rα and blocking both the IL-4 and IL-13 signals. Read More

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http://dx.doi.org/10.1016/j.alit.2020.01.002DOI Listing

IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases.

Allergol Int 2020 Jan 21. Epub 2020 Jan 21.

Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.

Interleukin (IL)-24 is a member of the IL-20 family of cytokines and is produced by various types of cells, such as CD4 T cells, NK cells, mast cells, keratinocytes, bronchial epithelial cells, and myofibroblasts. Previous studies suggest that IL-24 plays an essential role in the pathogenesis of pro-inflammatory autoimmune disorders such as psoriasis, arthritis, and inflammatory bowel diseases. However, the role of IL-24 in the pathogenesis of allergic diseases has been elusive. Read More

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http://dx.doi.org/10.1016/j.alit.2019.12.003DOI Listing
January 2020

Relationship between gut microbiota composition and sensitization to inhaled allergens.

Allergol Int 2020 Jan 22. Epub 2020 Jan 22.

Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan.

Background: An imbalance in gut microbiota is implicated in several pathological conditions, including allergic diseases. This study investigates the association between gut microbiota composition and sensitization to two inhaled antigens.

Methods: The study comprised 1109 local residents who had participated in the Iwaki Health Promotion Project in 2016. Read More

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http://dx.doi.org/10.1016/j.alit.2019.12.010DOI Listing
January 2020

Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses.

Allergol Int 2020 Apr 21;69(2):197-203. Epub 2020 Jan 21.

Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address:

TSLP is an epithelial cell-derived cytokine synthesized in response to various stimuli, including protease allergens and microorganisms like viruses and bacteria. Biological functions of TSLP require heterodimer formation between the TSLP receptor (TSLPR) and IL-7 receptor-α, which polarize dendritic cells to induce type 2 inflammation and directly expand and/or activate Th2 cells, group 2 innate lymphoid cells, basophils, and other immune cells. TSLP is thus considered a master regulator of type 2 immune responses at the barrier surfaces of skin and the respiratory/gastrointestinal tract. Read More

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http://dx.doi.org/10.1016/j.alit.2020.01.001DOI Listing

Novel in vitro test for pollen-related vegetable/fruit allergy using the EXiLE method.

Allergol Int 2020 Jan 18. Epub 2020 Jan 18.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kanagawa, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.12.007DOI Listing
January 2020

A case of millet allergy that developed into wheat-induced anaphylaxis by cross-reaction between millet and wheat antigens.

Allergol Int 2020 Jan 17. Epub 2020 Jan 17.

Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.12.011DOI Listing
January 2020

A novel deep intronic SERPING1 variant as a cause of hereditary angioedema due to C1-inhibitor deficiency.

Allergol Int 2020 Jan 17. Epub 2020 Jan 17.

CeMIA SA, Larissa, Greece; Department of Immunology & Histocompatibility, University of Thessaly, School of Health Sciences, Faculty of Medicine, Larissa, Greece. Electronic address:

Background: In about 5% of patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) no mutation in the SERPING1 gene is detected.

Methods: C1-INH-HAE cases with no mutation in the coding region of SERPING1 after conventional genotyping were examined for defects in the intronic or untranslated regions of the gene. Using a next-generation sequencing (NGS) platform targeting the entire SERPING1, 14 unrelated C1-INH-HAE patients with no detectable mutations in the coding region of the gene were sequenced. Read More

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http://dx.doi.org/10.1016/j.alit.2019.12.009DOI Listing
January 2020

Overweight and bronchospasm during general anaesthesia: An association with heterogeneous mechanisms.

Allergol Int 2020 Jan 17. Epub 2020 Jan 17.

Department of Respiratory Medicine, University Hospital Centre of Toulouse, Toulouse, France; Centre for Pathophysiology of Toulouse Purpan, INSERM U1043, CNRS UMR 5282, Université Toulouse III, Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.12.012DOI Listing
January 2020

Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis.

Allergol Int 2020 Jan 14. Epub 2020 Jan 14.

Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine, Narita, Japan; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Electronic address:

Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS. Read More

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http://dx.doi.org/10.1016/j.alit.2019.12.004DOI Listing
January 2020

Anaphylaxis caused by maltose solution.

Allergol Int 2020 Jan 13. Epub 2020 Jan 13.

Department of Dermatology, Takatsuki General Hospital, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.12.008DOI Listing
January 2020

Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings.

Allergol Int 2020 Apr 10;69(2):232-238. Epub 2020 Jan 10.

Department of Otorhinolaryngology, Head & Neck Surgery, Kansai Medical University, Osaka, Japan.

Background: Eosinophilic chronic rhinosinusitis (ECRS) is a subtype of chronic rhinosinusitis associated with asthma. CD69 is an important marker of activation for eosinophils. But, whether a correlation exist between the CD69 expression on eosinophils and clinical findings is unclear. Read More

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http://dx.doi.org/10.1016/j.alit.2019.11.002DOI Listing

L-type amino acid transporter 1 (LAT1)-specific inhibitor is effective against T cell-mediated nasal hyperresponsiveness.

Allergol Int 2020 Jan 9. Epub 2020 Jan 9.

Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.12.006DOI Listing
January 2020

Current research gaps and unmet clinical needs in food allergy.

Authors:
Yukihiro Ohya

Allergol Int 2020 01;69(1):1-2

Allergy Center, National Center for Child Health and Development, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.alit.2019.12.002DOI Listing
January 2020

Exposure to cold airflow alters skin pH and epidermal filaggrin degradation products in children with atopic dermatitis.

Allergol Int 2019 Dec 26. Epub 2019 Dec 26.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, South Korea. Electronic address:

Background: We aimed to evaluate the influence of cold airflow from the air conditioner on skin barrier function and filaggrin degradation products (FDPs) in children with atopic deramtitis (AD).

Methods: In a case-control study, 28 children with AD and 12 normal children without AD were exposed to one of two air conditioner modes (conventional or wind-free) for 2 h. Skin temperature, transepidermal water loss (TEWL), and skin pH were measured on right cheek and forearm at pre- and post-exposure time points. Read More

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http://dx.doi.org/10.1016/j.alit.2019.11.004DOI Listing
December 2019

Effect of endoscopic sinus surgery for chronic rhinosinusitis on the state of coexisting asthma.

Allergol Int 2020 Apr 19;69(2):279-280. Epub 2019 Dec 19.

Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences, Aichi, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.12.001DOI Listing

Corrigendum to "Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts" [Allergol Int 65 (2016) 414-419].

Allergol Int 2020 01 12;69(1):163. Epub 2019 Dec 12.

Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.11.001DOI Listing
January 2020

Association between the AUDIT score and IgE in Korean adults: Results from the Korea National Health and Nutrition Examination Survey.

Allergol Int 2020 Apr 5;69(2):293-295. Epub 2019 Dec 5.

Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

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http://dx.doi.org/10.1016/j.alit.2019.10.010DOI Listing

Efficacy of immunoglobulin replacement therapy and azithromycin in severe asthma with antibody deficiency.

Allergol Int 2020 Apr 4;69(2):215-222. Epub 2019 Dec 4.

Department of Airway Diseases, Foch Hospital, Suresnes, France; Foch Hospital, Paris Saclay University, Suresnes, France.

Background: Although antibody deficiency (AD) is a well-known cause of recurrent respiratory infections, there are few data on its impact in adults with asthma. The objective of the present study was to assess outcomes in adults with severe asthma and AD after treatment with either azithromycin or subcutaneous immunoglobulins (SCIg).

Methods: We performed a 5-year, prospective, observational, two-centre study of adults with severe asthma and AD in France. Read More

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http://dx.doi.org/10.1016/j.alit.2019.10.011DOI Listing

Gibberellin-regulated protein allergy: Clinical features and cross-reactivity.

Authors:
Naoko Inomata

Allergol Int 2020 Jan 27;69(1):11-18. Epub 2019 Nov 27.

Department of Environmental Immuno-Dermatology, Yokohama City University School of Medicine, Yokohama, Japan. Electronic address:

Gibberellin-regulated proteins (GRPs)/GASA proteins are members of cysteine-rich antimicrobial peptide families and are conserved in a broad range of plants. Some GRPs in fruits and pollens have been identified as allergens including peach Pru p 7, Japanese apricot Pru m 7, orange Cit s 7, pomegranate Pun g 7, and cypress pollen GRP. The clinical features of fruit-derived GRP allergies frequently include systemic reactions, multiple fruit allergies regardless of plant kingdom classifications and, less frequently, cofactor-dependence. Read More

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http://dx.doi.org/10.1016/j.alit.2019.10.007DOI Listing
January 2020