Search our Database of Scientific Publications and Authors

I’m looking for a

    2715 results match your criteria Allergologia et Immunopathologia [Journal]

    1 OF 55

    Future prospect of faecal microbiota transplantation as a potential therapy in asthma.
    Allergol Immunopathol (Madr) 2017 Aug 10. Epub 2017 Aug 10.
    Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China; Pathogen Biology Laboratory, Kunming University of Science and Technology, Kunming, Yunnan, China.
    There is convincing evidence from both human and animal studies suggesting that the gut microbiota plays an important role in regulating immune responses associated with the development of asthma. Certain intestinal microbial strains have been demonstrated to suppress or impair immune responsiveness in asthma experimental models, suggesting that specific species among gut commensal microbiota may play either a morbific or phylactic role in the progression of asthma. Evidence to date suggests that the intestinal microbiota represent fertile targets for prevention or management of asthma. Read More

    Sinomenine ameliorates the airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in a murine model of chronic asthma.
    Allergol Immunopathol (Madr) 2017 Aug 1. Epub 2017 Aug 1.
    Dokuz Eylul University, Department of Pediatric Allergy and Immunology, Izmir, Turkey.
    Background: Sinomenine (SIN), an alkaloid isolated from the root of Sinomenium acutum which has a variety of pharmacological effects, including anti-inflammation, immunosuppression and anti-angiogenesis. The present study aimed to evaluate the effects of SIN on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.

    Methods: Twenty-two BALB/c mice were divided into four groups; I (control), II (placebo), III, IV. Read More

    Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy.
    Allergol Immunopathol (Madr) 2017 Jul 27. Epub 2017 Jul 27.
    Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Electronic address:
    Background: Low vitamin D status is linked to increased incidence of food allergy and intestinal inflammation. Whether vitamin D status is associated with immunological changes in children with gastrointestinal food allergy (GFA) remains unclear.

    Methods: Forty-nine GFA children (aged 2-11 years old) were enrolled in this study. Read More

    Air pollution and its relationship to lung function among adolescents from Taubate, São Paulo, Brazil.
    Allergol Immunopathol (Madr) 2017 Jul 27. Epub 2017 Jul 27.
    Division of Allergy,Clinical Immunology and Rheumatology, Department of Pediatrics, Escola Paulista de Medicina, University of São Paulo, São Paulo, Brazil.
    Background: This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil.

    Methods: This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté. Read More

    Evaluation of the frequency of food allergens based on skin prick test in children in Kurdistan Province - Iran.
    Allergol Immunopathol (Madr) 2017 Jul 24. Epub 2017 Jul 24.
    Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address:
    Introduction: Food allergy refers to abnormal reactions of the body caused by an immune system response to food. This study was conducted aiming to investigate allergy to food allergens in children with food allergies.

    Materials And Methods: This study was conducted as a cross-sectional one on 304 children aged six months to seven years with food allergies admitted to the tertiary referral hospital in Kurdistan Province - Iran, during 2014-2015. Read More

    Component-resolved diagnosis in hymenoptera allergy.
    Allergol Immunopathol (Madr) 2017 Jul 21. Epub 2017 Jul 21.
    Servicio de Alergología, Hospital Universitario de Guadalajara, Guadalajara, Spain.
    Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Read More

    Single and multiple food allergies in infants with proctocolitis.
    Allergol Immunopathol (Madr) 2017 Jul 21. Epub 2017 Jul 21.
    Department of Pediatrics, Division of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey.
    Background: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined.

    Objective: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. Read More

    Autoimmunity and its association with regulatory T cells and B cell subsets in patients with common variable immunodeficiency.
    Allergol Immunopathol (Madr) 2017 Jul 20. Epub 2017 Jul 20.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Background: Common variable immunodeficiency (CVID) is one of the most prevalent symptomatic primary immunodeficiencies (PIDs), which manifests a wide clinical variability such as autoimmunity, as well as T cell and B cell abnormalities.

    Methods: A total of 72 patients with CVID were enrolled in this study. Patients were evaluated for clinical manifestations and classified according to the presence or absence of autoimmune disease. Read More

    Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age.
    Allergol Immunopathol (Madr) 2017 Jul 15. Epub 2017 Jul 15.
    Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Umuttepe Yerleskesi, 41380 İzmit, KOCAELİ, Turkey. Electronic address:
    Background: IgE-mediated cow's milk allergy (CMA) has been shown consistent in milder heated-milk tolerant and severe heated-milk reactant groups in patients older than two years. Little is known whether fermentation of milk gives rise to similar clinical phenotypes. We aimed to determine the influence of extensively heated and fermented cow's milk on the IgE-mediated and non-IgE-mediated CMA in children younger than two years. Read More

    MHC class II deficiency: Report of a novel mutation and special review.
    Allergol Immunopathol (Madr) 2017 Jul 1. Epub 2017 Jul 1.
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increased susceptibility to respiratory and gastrointestinal infections, failure to thrive and early mortality. This syndrome is caused by mutations in transcription regulators of the MHC II gene and results in development of blind lymphocytes due to the lack of indicatory MHC II molecules. Despite homogeneity of clinical manifestations of patients with MHC II deficiency, the genetic defects underlying this disease are heterogeneous. Read More

    Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):508-518. Epub 2017 Jul 1.
    Pediatric Allergy, Department of Medicine, Imperial College London, United Kingdom.
    Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Read More

    Incidence of asthma in young adults from Castellon, Spain: A prospective cohort study.
    Allergol Immunopathol (Madr) 2017 Jul 1. Epub 2017 Jul 1.
    Epidemiologic Division, Public Health Centre, Castellon, Spain; CIBER: Epidemiology and Public Health (CIBERESP), Barcelona, Spain.
    Background: The objective was to estimate the incidence of asthma in young adults from 13-15 years old to 23-25 years old, and associated factors.

    Methods: In 2012, a population-based prospective cohort study was carried out in Castellon from the cohort who had participated in the International Study of Asthma and Allergy in Childhood in 1994 and 2002. A telephone survey was undertaken using the same questionnaires. Read More

    Effects of icariin on asthma mouse model are associated with regulation of prostaglandin D2 level.
    Allergol Immunopathol (Madr) 2017 Jun 29. Epub 2017 Jun 29.
    Department of Respiratory Medicine, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Background: We aimed to observe the effect of icariin on an asthma mouse model and explore the potential underlying mechanisms.

    Methods: The asthma mouse model was established by ovalbumin (OVA) sensitisation and respiratory syncytial virus (RSV) infection and then treated with icariin. Airway resistance was assessed by whole body plethysmograph. Read More

    Bronchopulmonary dysplasia as a risk factor for asthma in school children and adolescents: A systematic review.
    Allergol Immunopathol (Madr) 2017 Jun 28. Epub 2017 Jun 28.
    Pediatric Pulmonology and Allergy Unit, University Hospital La Ribera, Alzira, Valencia, Spain.
    Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects extremely pre-term infants, and remains the most common complication of prematurity. Several studies have shown that prematurity predisposes to the development of asthma in school children and adolescents. Nevertheless, it is not clear to what extent a history of BPD involves an additional risk. Read More

    Oral immunotherapy for food allergy: A Spanish guideline. Immunotherapy egg and milk Spanish guide (items guide). Part I: Cow milk and egg oral immunotherapy: Introduction, methodology, rationale, current state, indications contraindications and oral immunotherapy build-up phase.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):393-404. Epub 2017 Jun 26.
    Pediatric Allergy, Department of Medicine, Imperial College London, United Kingdom.
    Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Read More

    Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.
    Allergol Immunopathol (Madr) 2017 Jun 20. Epub 2017 Jun 20.
    Department of Pediatrics, Ain Shams University, Egypt.
    Background: In recent years, the prevalence of asthma has risen in developed countries, and its extent related to a change in our indigenous microbiota. Helicobacter pylori disappearance across the population represents a fundamental change in our human microbiota and has preceded the rise in asthma prevalence.

    Objective: To assess the relationship between childhood asthma and Helicobacter pylori infection. Read More

    Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients.
    Allergol Immunopathol (Madr) 2017 Jun 20. Epub 2017 Jun 20.
    Bagcilar Training and Research Hospital, Clinicis Pediatrics, Istanbul, Turkey.
    Background: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment.

    Objective: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation.

    Methods: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. Read More

    Does atopy affect the course of viral pneumonia?
    Allergol Immunopathol (Madr) 2017 Jun 17. Epub 2017 Jun 17.
    Marmara University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, Turkey.
    Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia.

    Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Read More

    A comparison of two clinical scores for bronchiolitis. A multicentre and prospective study conducted in hospitalised infants.
    Allergol Immunopathol (Madr) 2017 Jun 16. Epub 2017 Jun 16.
    Hospital de Sagunto, Avda Ramón y Cajal s.n, Sagunto, 46520 Valencia, Spain.
    Background: There are a number of clinical scores for bronchiolitis but none of them are firmly recommended in the guidelines.

    Method: We designed a study to compare two scales of bronchiolitis (ESBA and Wood Downes Ferres) and determine which of them better predicts the severity. A multicentre prospective study with patients <12 months with acute bronchiolitis was conducted. Read More

    The safety profile of subcutaneous allergen immunotherapy in children with asthma in Hangzhou, East China.
    Allergol Immunopathol (Madr) 2017 Jun 16. Epub 2017 Jun 16.
    Department of Respiratory Medicine, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:
    Background: The aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (SRs) to subcutaneous allergen immunotherapy (SCIT) in children and adolescents with asthma in Hangzhou, east China's Zhejiang province.

    Methods: From January 2011 to December 2016, this survey analysed the SCIT-related SRs involving 429 patients (265 children and 134 adolescents) affected by allergic asthma. Recorded data included demographics, diagnosis, patient statuses, pulmonary function testing results before and after each injection, allergen dosage, and details of SRs. Read More

    Oral immunisation with Taishan Pinus massoniana pollen polysaccharide adjuvant with recombinant Lactococcus lactis-expressing Proteus mirabilis ompA confers optimal protection in mice.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):496-505. Epub 2017 Jun 16.
    Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Shandong Taian 271018, PR China. Electronic address:
    Background: Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals.

    Method: A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. Read More

    Trends in prevalence and risk factors of allergic rhinitis symptoms in primary schoolchildren six years apart in Budapest.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):487-495. Epub 2017 Jun 17.
    Department of Pulmonology, Semmelweis University Budapest, 1/c Diós árok, Budapest H-1125, Hungary.
    Background: Few data are available concerning the time trends and risk factors associated with allergic rhinitis (AR) in schoolchildren in Hungary.

    Methods: At an interval of six years, parents of 6-12-year-old children completed identical ISAAC-based and additional questionnaires related to possible risk factors.

    Results: Response rate was 62. Read More

    Influence of the Mediterranean diet during pregnancy in the development of wheezing and eczema in infants in Pamplona, Spain.
    Allergol Immunopathol (Madr) 2017 Jun 16. Epub 2017 Jun 16.
    Navarra Institute for Health Research (IdiSNA), Spain; Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
    Background: This study examined the relationship between different food groups and the adherence to a Mediterranean diet during pregnancy and the risk of wheezing and eczema in children aged 12-15 months.

    Methods: The study involves 1087 Spanish infants from the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). The study of the association of the different food consumption and Mediterranean diet with wheezing, recurrent wheezing and eczema was performed using different models of unconditional logistic regression to obtain adjusted prevalence odds ratios (OR) and 95% confidence intervals (95% CI). Read More

    The protective role of Helicobacter pylori neutrophil-activating protein in childhood asthma.
    Allergol Immunopathol (Madr) 2017 May 31. Epub 2017 May 31.
    Istanbul University, Department of Medical Microbiology Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address:
    Background: Helicobacter pylori quantity and HP-NAP gene expression were evaluated in the faeces of healthy and asthmatic children.

    Methods: H. pylori DNAs and RNAs were isolated from the stool samples of 92 asthmatic children (AC; 3-8 years) and 88 healthy controls (HC). Read More

    Plasticity of immune system vs. memory therapy IST.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):482-486. Epub 2017 May 23.
    Dermatology Unit*, NESMOS Department, S. Andrea Hospital, University of Rome "Sapienza", Rome, Italy.
    Background: Pharmacotherapy and immunotherapy are the main treatments for allergic diseases to inhalants.

    Objective: This study investigates whether to repeat short cycles of immunotherapy after 3 or 5 years the from interruption of the first therapeutic cycle, lasting 3-4 years, to maintain immune memory in individuals subjected to IST.

    Methods And Results: We have compared two groups, one of 452 patients who, after the first treatment for 3-4 years of IST, performed a cycle of four months after three and 10 years from the suspension, and a second group of 126 individuals who have performed only the IST treatment for 3-4 years. Read More

    True and false contraindications to vaccines.
    Allergol Immunopathol (Madr) 2017 May 8. Epub 2017 May 8.
    Department of Clinical and Experimental Medicine, Section of Paediatrics UO Pediatria, University of Pisa, via Roma 67, Pisa, Italy.
    Nowadays, the awareness of risks related to infectious diseases has decreased, whereas THE perception of risks related to vaccination is growing. Therefore, it may be difficult for health care providers to convince people of the importance of vaccination and adherence to the immunisation schedule. Selected situations that might raise uncertainties about vaccine recommendations are discussed in order to help health care providers to identify real and perceived contraindications to vaccines, and cases to be referred to specialised pre-vaccination consultation due to an increased risk of adverse events to vaccines. Read More

    Impact of meteorological factors on the emergence of bronchiolitis in North-western Greece.
    Allergol Immunopathol (Madr) 2017 May 5. Epub 2017 May 5.
    Laboratory of Meteorology, Department of Physics, University of Ioannina, Ioannina, Greece.
    Objective: To evaluate the relationship between meteorological factors in North-western Greece and the incidence of bronchiolitis.

    Methods: Meteorological data (air temperature and rainfall) for Ioannina city in North-western Greece and medical data from hospitalised patients at University Hospital of Ioannina were collected between January 2002 and December 2013. The association between meteorological factors and rate of hospitalisation due to bronchiolitis was investigated. Read More

    A rural environment does not protect against asthma or other allergic diseases amongst Mexican children.
    Allergol Immunopathol (Madr) 2017 May 3. Epub 2017 May 3.
    División de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador de Quevedo y Zubieta No. 750, Colonia La Perla, Guadalajara, Jalisco C.P. 44340, Mexico.
    Introduction: The commonly held notion that a rural environment decreases the frequency of allergic diseases has proven to be inconsistent amongst children.

    Objective: Our objective was to contrast the prevalence of bronchial asthma (BA), allergic rhinitis (AR), and atopic dermatitis (AD) between children that live in a rural environment and those that live in urban areas.

    Methods: We carried out a cross-sectional study amongst children aged six to seven; they were selected through probabilistic, stratified and conglomerated sampling. Read More

    Recent thymic emigrants, T regulatory cells, and BAFF level in children with X-linked agammaglobulinaemia in association with chronic respiratory disease.
    Allergol Immunopathol (Madr) 2017 May 3. Epub 2017 May 3.
    Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk Region, Belarus.
    Background: X-linked agammaglobulinaemia (XLA) is a genetic disorder affecting B cell maturation, which is characterised by a low number of B cells, agammaglobulinaemia and increased susceptibility to a variety of bacterial infections. This study was performed to assess T cell subpopulations in a group of children with XLA in association with chronic respiratory disease (CRD).

    Methods: Numbers of T cell subpopulations (CD3+, CD4+, CD8+, CD3+DR+, naïve, memory, recent thymic emigrants (RTE), regulatory T cells, follicular T helpers) were measured by eight-colour flow cytometry in 22 XLA patients and 50 controls. Read More

    Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls?
    Allergol Immunopathol (Madr) 2017 Apr 29. Epub 2017 Apr 29.
    Acıbadem University Medical Faculty, Pediatrics Unit, Turkey.
    Introduction: There are only a few studies regarding the prevalence of atopy in Familial Mediterranean fever (FMF) patients, and their results are conflicting.

    Methods: In this study children with the diagnosis of FMF were evaluated for the presence of atopy by comparing with controls. One hundred and eighteen children diagnosed as FMF and 50 healthy age and sex matched controls were enrolled. Read More

    Epidemiology and pathophysiology of malignancy in common variable immunodeficiency?
    Allergol Immunopathol (Madr) 2017 Apr 12. Epub 2017 Apr 12.
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Common variable immunodeficiency (CVID) is a diagnostic category of primary immunodeficiency (PID) which may present with heterogeneous disorders including recurrent infections, autoimmunity, granulomatous diseases, lymphoid and other types of malignancies. Generally, the incidence of malignancy in CVID patients is around 1.5-20. Read More

    Nutrition in the first 1000 days and respiratory health: A descriptive review of the last five years' literature.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):405-413. Epub 2017 Apr 12.
    Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, Italy.
    The aim of this paper is to discuss the current evidence regarding short and long-term health respiratory effects of nutrients and dietary patterns during the first 1000 days from conception. Population of interest included children from birth to two years and their mothers (during pregnancy and lactation). Studies were searched on MEDLINE® and Cochrane database, inserting individually and using the Boolean ANDs and ORs, 'nutrients', 'micronutrients', 'LC-PUFA', 'Mediterranean Diet', 'human milk', 'complementary food', 'pregnancy', 'respiratory disease', 'pulmonary disease', 'asthma', 'epigenetics', 'first 1000 days', 'maternal diet' and 'respiratory health'. Read More

    Serum levels of adiponectin and leptin in asthmatic patients and its relation with asthma severity, lung function and BMI.
    Allergol Immunopathol (Madr) 2017 May - Jun;45(3):258-264
    Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address:
    Introduction: Asthma is one of the diseases which has a high prevalence in developed and developing countries. The relationship between asthma and obesity has always been focused by researchers. In this field, adipokines, especially adiponectin and leptin have highly attended by the scientist. Read More

    Predictivity of clinical efficacy of sublingual immunotherapy (SLIT) based on sensitisation pattern to molecular allergens in children with allergic rhinoconjunctivitis.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):452-456. Epub 2017 Apr 11.
    Department of Pediatrics, Sapienza University of Rome, Italy.
    Background: The diagnostic and therapeutic approach to grass pollen allergy is now possible by detecting specific IgE (sIgE) to its allergenic components.

    Aim: To evaluate the correlation between the sensitisation to different molecular Phleum pratense (Phl p) allergens and clinical efficacy of SLIT.

    Methods: The pilot study included 36 patients affected by allergic rhinoconjunctivitis, all treated with SLIT actively. Read More

    Under the superficial dichotomy pathogen and allergen are two manifestations of same immune activation and pathogenesis mechanisms.
    Allergol Immunopathol (Madr) 2017 Apr 11. Epub 2017 Apr 11.
    Bioinformatics and Medical Informatics Research Center, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182, United States. Electronic address:
    Pathogens and allergens are deemed as two contrasting facets of host immune status, deficiency and exuberant. In silico domain analysis of a diverse panel of pathogen and allergen proteins has revealed the shortcoming of this notion. Both the pathogen and allergen proteins elicit immune activation, with the outcome of immune agitation depending on the pathogen strain, allergen exposure duration, and host factors. Read More

    Prevalence and risk factors for wheezing and allergic diseases in preschool children: A perspective from the Mediterranean coast of Turkey.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):362-368. Epub 2017 Apr 11.
    Mersin University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Mersin, Turkey.
    Objectives: The aim of the present study was to determine the prevalence and risk factors of allergic diseases in preschool children from one of the biggest cities in the Mediterranean Region of Turkey.

    Methods: The study population included 396 preschool children attending to urban daycare centres in Mersin. In the first stage, a comprehensive standardised questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC) was employed. Read More

    Is the evidence of breast feeding protection against coeliac disease real?
    Allergol Immunopathol (Madr) 2017 Apr 11. Epub 2017 Apr 11.
    Babes-Bolyai University, Department of Molecular Biology and Biotechnology, Cluj-Napoca, Romania.
    Many recent studies discredit breastfeeding protection against coeliac disease. We will try to answer the question: "Is the evidence of breast feeding protection against coeliac disease real?" Read More

    Interleukin-33 in children with asthma: A systematic review and meta-analysis.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):387-392. Epub 2017 Apr 11.
    Department of Respiratory Medicine, The First Hospital of Jilin University, Changchun, China. Electronic address:
    Background: Previous studies have shown that serum interleukin 33 serving as an "alarmin" is increased in children with asthma. The objective of this study was to assess the validity of serum IL33 test for early diagnosis of childhood asthma.

    Methods: A literature search was performed in June 2016 using PubMed, Embase, the Cochrane Library and other Chinese Medical Databases to identify studies. Read More

    Molecular diagnosis of allergy to Anisakis simplex and Gymnorhynchus gigas fish parasites.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):463-472. Epub 2017 Mar 22.
    Laboratorios Diater, Madrid, Spain.
    Background: There has been an increase in the prevalence of hypersensitivity to Anisakis simplex. There are fish parasites other than Anisakis simplex whose allergenicity has not yet been studied.

    Objective: To assess IgE hypersensitivity caused by fish parasite allergens in patients with gastro-allergic symptoms after consumption of fish, shellfish or cephalopods, compared with healthy subjects, pollen allergic individuals and children with digestive symptoms after eating marine food. Read More

    Asthma education taught by physical education teachers at grade schools: A randomised cluster trial.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):375-386. Epub 2017 Mar 18.
    Andalusian Health Care Service, San Jerónimo Medical Center, Sevilla, Spain.
    Objective: Assess whether the Asthma, Sport and Health (ASAH) programme taught by teachers improves asthmatics' quality of life, asthma knowledge, and reduces school absenteeism.

    Design: Randomised cluster trial parallel group.

    Participants: 2293 students (203 asthmatic) in the Intervention School group (IS) and 2214 in the Comparison School (CS) (224 asthmatic) belonging to primary school. Read More

    Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):432-438. Epub 2017 Mar 2.
    Department of Paediatrics, Jiangsu Taizhou People's Hospital, Taizhou, China. Electronic address:
    Objective: To investigate whether the genetic variants of TGFB1, TLE4, MUC22 and IKZF3 are associated with the development of asthma in Chinese children.

    Methods: 572 adolescent asthma patients and 590 age-matched healthy controls were included in this study. A total of four SNPs were genotyped, including rs2241715 of TGFB1, rs2378383 of TLE4, rs2523924 of MUC22, and rs907092 of IKZF3. Read More

    Allergy is associated with reduced risk of glioma: A meta-analysis.
    Allergol Immunopathol (Madr) 2017 Mar 2. Epub 2017 Mar 2.
    School of Public Health, Anhui Medical University, Hefei City, Anhui Province, China.
    Background: Increasing evidences suggest that allergy may reduce the risk of glioma, so it is necessary to perform an up-to-data literature search and investigate this relationship by meta-analysis.

    Methods: We identified the included studies by searching PubMed and Web of Science and excluding irrelevant or ineligible articles. Nineteen studies from 15 articles, including 8435 cases and 118,719 controls, were selected for data extraction and synthesis. Read More

    Comparison of inflammatory cytokine release from nasal epithelial cells of non-atopic non-rhinitic, allergic rhinitic and polyp subjects and effects of diesel exhaust particles in vitro.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):473-481. Epub 2017 Mar 2.
    Koc University School of Medicine, Department of Chest Diseases, İstanbul, Turkey; University of Gaziantep, School of Medicine, Department of Chest Diseases, Division of Allergy and Immunology, Gaziantep, Turkey.
    Background: Although studies have reported an association between air pollutants and increased allergic airway diseases, such as allergic rhinitis and nasal polyposis, the underlying mechanisms are not fully understood. A limited number of studies have suggested that diesel exhaust particles (DEP) play a role in atopy and the pathogenesis of allergic upper airway diseases. The aim of this study was to investigate the effect of DEP on inflammatory cytokine release, and mRNA expression of transcription factors such as JNK and NF-β in primary nasal epithelial cells (NECs), in vitro. Read More

    Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):339-349. Epub 2017 Feb 28.
    Dokuz Eylul University, Department of Pediatric Allergy and Immunology, Izmir, Turkey.
    Background And Aims: In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.

    Methods: Twenty-seven BALB/c mice were divided into five groups; PBS-Control, OVA-Placebo, OVA-50mg/kg UDCA, OVA-150mg/kg UDCA, OVA-Dexamethasone. Read More

    Knowledge of asthma and anaphylaxis among teachers in Spanish schools.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):369-374. Epub 2017 Feb 21.
    Consorcio Hospital General Universitario, Valencia, Spain.
    Introduction: Allergic diseases affect 15-20% of the paediatric population in the industrialised world. Most educational centres in Spain do not have health professionals among their staff, and the teachers are in charge of child care in school. The advisability of specific training of the teaching staff should be considered, with the introduction of concrete intervention plans in the event of life-threatening emergencies in schools. Read More

    Increased sputum levels of thymus and activation-regulated chemokine in children with asthma not eosinophilic bronchitis.
    Allergol Immunopathol (Madr) 2017 May - Jun;45(3):220-226. Epub 2017 Feb 21.
    Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Background: Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine family, plays a crucial role in Th2-specific inflammation. We aimed to determine the concentration of sputum TARC in children with asthma and eosinophilic bronchitis (EB) and its relation with eosinophilic inflammation, pulmonary function, and bronchial hyper-responsiveness.

    Methods: In total, 90 children with asthma, 38 with EB, and 45 control subjects were enrolled. Read More

    1 OF 55