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    2734 results match your criteria Allergologia et Immunopathologia [Journal]

    1 OF 55

    Tablet-based sublingual immunotherapy for respiratory allergy.
    Allergol Immunopathol (Madr) 2017 Dec 13;45 Suppl 1:30-35. Epub 2017 Nov 13.
    Sección de Alergologia, Hospital Dr Peset and Universidad de Valencia, Spain. Electronic address:
    Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Read More

    Quality requirements for allergen extracts and allergoids for allergen immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 9;45 Suppl 1:4-11. Epub 2017 Nov 9.
    Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, Langen, Germany. Electronic address:
    All allergen products for allergen immunotherapy currently marketed in the European Union are pharmaceutical preparations derived from allergen-containing source materials like pollens, mites and moulds. Especially this natural origin results in particular demands for the regulatory requirements governing allergen products. Furthermore, the development of regulatory requirements is complicated by the so far missing universal link between certain quality parameters, in particular biological potency, on the one hand and clinical efficacy on the other hand. Read More

    Non-protease native allergens partially purified from bodies of eight domestic mites using p-aminobenzamidine ligand.
    Allergol Immunopathol (Madr) 2017 Nov 8. Epub 2017 Nov 8.
    Medical Center Prague, Mezi Vodami 205/29, Prague 4-Modrany, CZ-14300, Czech Republic.
    Background: Optimised purification steps for concentrating trace target native antigens are needed. Combining the p-aminobenzamidine ligand with protease inactivation enables partial purification of mite non-protease allergens lacking proteases.

    Objective: We sought to analyse in detail proteins obtained using this method from eight species of synanthropic acaridid mites and tested IgE reactivity using pooled human sera. Read More

    Predictive biomarkers in allergen specific immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:12-14. Epub 2017 Nov 3.
    IMMA, Institute of Applied Molecular Medicine, Faculty of Medicine, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain; Basic Medical Sciences Department, Faculty of Medicine, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain.

    Biologics in the treatment of severe asthma.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:45-49. Epub 2017 Nov 3.
    Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain; CIBER de Enfermedades Respiratorias, CIBERES, Spain.
    Severe asthma is defined as asthma which requires treatment with high dose inhaled corticosteroids and with a second controller drug to prevent it from becoming uncontrolled or which remains uncontrolled despite this therapy. Patients with uncontrolled severe asthma require additional treatment options as add-on therapy, including biologics. Biologic therapies in asthma are designed to block key immune regulators, such as IgE, or certain pro-inflammatory cytokines, e. Read More

    New insight into cancer immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:50-55. Epub 2017 Nov 3.
    IMMA, Institute of Applied Molecular Medicine, Faculty of Medicine, CEU San Pablo University, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain.
    A key point for maintenance of the immune system homeostasis is the balance between the capacity to recognize and fight exogenous molecules and the capacity to avoid auto reactivity. The disruption of this balance induces the progression of several immune diseases such as autoimmune diseases, allergies, infections or cancer. A promising therapeutic approach to treat these diseases is immunotherapy. Read More

    Proposals for harmonization of allergens regulation in the European Union.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:1-3. Epub 2017 Nov 3.
    Biological Products, Advanced Therapies and Biotechnology Division, Agencia Española de Medicamentos y Productos Sanitarios, Campezo 1, 28022 Madrid, Spain. Electronic address:
    Allergen medicinal products in the European Union are regulated differently across the different Member States. Thus, whereas in some countries strict quality, safety and efficacy requirements are in place, in others, most allergens are on the market as Named Patient Products, without any regulatory oversight. This situation results on European allergic patients being exposed to totally different standards depending on where they live. Read More

    Validation of a Spanish version of the EuroPrevall Food Allergy Quality of Life Questionnaire-Parental Form.
    Allergol Immunopathol (Madr) 2017 Oct 12. Epub 2017 Oct 12.
    Unit of Pediatric Allergy and Pneumology, Instituto de Investigación Sanitaria, Hospital Universitario y Politécnico La Fe, Valencia, Spain. Electronic address:
    Background: Food allergy can have a major impact on quality of life of children and their parents. Questionnaires have been developed to measure the impact of this disorder. We aimed to validate the EuroPrevall questionnaire on Food Allergy-Quality of Life Questionnaire, Parent Form (FAQLQ-PF) and the Food Allergy Independent Measure (FAIM), translated into Spanish. Read More

    Low efficacy of atopy patch test in predicting tolerance development in non-IgE-mediated cow's milk allergy.
    Allergol Immunopathol (Madr) 2017 Oct 11. Epub 2017 Oct 11.
    Food Allergy Research Group, Pediatrics Department, Universidade Federal de Uberlandia, Brazil. Electronic address:
    Background: The food atopy patch (APT) test has been used in previous studies to help the diagnosis of non-IgE mediated food allergies (FA). The aim of this study was to evaluate the efficacy of different cow's milk APT preparations to predict oral tolerance in children with previous non-IgE-mediated cow's milk allergy (CMA) diagnosis.

    Methods: Thirty-two patients non-IgE-mediated CMA diagnosed by oral food challenge (OFC) were enrolled to perform APT with three different cow's milk preparations (fresh, 2% in saline solution, 2% in petrolatum) and comparing with a new OFC after at least three months of diet exclusion. Read More

    Changing perspectives in atopic dermatitis.
    Allergol Immunopathol (Madr) 2017 Oct 11. Epub 2017 Oct 11.
    Department of Allergology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain. Electronic address:
    Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Read More

    Future prospect of faecal microbiota transplantation as a potential therapy in asthma.
    Allergol Immunopathol (Madr) 2017 Aug 10. Epub 2017 Aug 10.
    Medical School, Kunming University of Science and Technology, Kunming, Yunnan, China; Pathogen Biology Laboratory, Kunming University of Science and Technology, Kunming, Yunnan, China.
    There is convincing evidence from both human and animal studies suggesting that the gut microbiota plays an important role in regulating immune responses associated with the development of asthma. Certain intestinal microbial strains have been demonstrated to suppress or impair immune responsiveness in asthma experimental models, suggesting that specific species among gut commensal microbiota may play either a morbific or phylactic role in the progression of asthma. Evidence to date suggests that the intestinal microbiota represent fertile targets for prevention or management of asthma. Read More

    Sinomenine ameliorates the airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in a murine model of chronic asthma.
    Allergol Immunopathol (Madr) 2017 Aug 1. Epub 2017 Aug 1.
    Dokuz Eylul University, Department of Pediatric Allergy and Immunology, Izmir, Turkey.
    Background: Sinomenine (SIN), an alkaloid isolated from the root of Sinomenium acutum which has a variety of pharmacological effects, including anti-inflammation, immunosuppression and anti-angiogenesis. The present study aimed to evaluate the effects of SIN on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.

    Methods: Twenty-two BALB/c mice were divided into four groups; I (control), II (placebo), III, IV. Read More

    Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy.
    Allergol Immunopathol (Madr) 2017 Jul 27. Epub 2017 Jul 27.
    Gastroenterology Unit, Nanjing Children's Hospital Affiliated with Nanjing Medical University, 72 Guangzhou Road, Nanjing, Jiangsu 210008, China. Electronic address:
    Background: Low vitamin D status is linked to increased incidence of food allergy and intestinal inflammation. Whether vitamin D status is associated with immunological changes in children with gastrointestinal food allergy (GFA) remains unclear.

    Methods: Forty-nine GFA children (aged 2-11 years old) were enrolled in this study. Read More

    Air pollution and its relationship to lung function among adolescents from Taubate, São Paulo, Brazil.
    Allergol Immunopathol (Madr) 2017 Jul 27. Epub 2017 Jul 27.
    Division of Allergy,Clinical Immunology and Rheumatology, Department of Pediatrics, Escola Paulista de Medicina, University of São Paulo, São Paulo, Brazil.
    Background: This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil.

    Methods: This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté. Read More

    Evaluation of the frequency of food allergens based on skin prick test in children in Kurdistan Province - Iran.
    Allergol Immunopathol (Madr) 2017 Jul 24. Epub 2017 Jul 24.
    Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic address:
    Introduction: Food allergy refers to abnormal reactions of the body caused by an immune system response to food. This study was conducted aiming to investigate allergy to food allergens in children with food allergies.

    Materials And Methods: This study was conducted as a cross-sectional one on 304 children aged six months to seven years with food allergies admitted to the tertiary referral hospital in Kurdistan Province - Iran, during 2014-2015. Read More

    Component-resolved diagnosis in hymenoptera allergy.
    Allergol Immunopathol (Madr) 2017 Jul 21. Epub 2017 Jul 21.
    Servicio de Alergología, Hospital Universitario de Guadalajara, Guadalajara, Spain.
    Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api m1), hyaluronidase (Api m2) and melittin (Api m4). Read More

    Single and multiple food allergies in infants with proctocolitis.
    Allergol Immunopathol (Madr) 2017 Jul 21. Epub 2017 Jul 21.
    Department of Pediatrics, Division of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey.
    Background: Food protein-induced allergic proctocolitis is a frequent cause of rectal bleeding in infants. Characteristics of infants with multiple food allergies have not been defined.

    Objective: This study aimed to identify characteristics of infants with proctocolitis and compare infants with single and multiple food allergies. Read More

    Autoimmunity and its association with regulatory T cells and B cell subsets in patients with common variable immunodeficiency.
    Allergol Immunopathol (Madr) 2017 Jul 20. Epub 2017 Jul 20.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Background: Common variable immunodeficiency (CVID) is one of the most prevalent symptomatic primary immunodeficiencies (PIDs), which manifests a wide clinical variability such as autoimmunity, as well as T cell and B cell abnormalities.

    Methods: A total of 72 patients with CVID were enrolled in this study. Patients were evaluated for clinical manifestations and classified according to the presence or absence of autoimmune disease. Read More

    Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age.
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):560-566. Epub 2017 Jul 15.
    Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Umuttepe Yerleskesi, 41380 İzmit, KOCAELİ, Turkey. Electronic address:
    Background: IgE-mediated cow's milk allergy (CMA) has been shown consistent in milder heated-milk tolerant and severe heated-milk reactant groups in patients older than two years. Little is known whether fermentation of milk gives rise to similar clinical phenotypes. We aimed to determine the influence of extensively heated and fermented cow's milk on the IgE-mediated and non-IgE-mediated CMA in children younger than two years. Read More

    MHC class II deficiency: Report of a novel mutation and special review.
    Allergol Immunopathol (Madr) 2017 Jul 1. Epub 2017 Jul 1.
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    The MHC II deficiency is a rare autosomal recessive primary immunodeficiency syndrome with increased susceptibility to respiratory and gastrointestinal infections, failure to thrive and early mortality. This syndrome is caused by mutations in transcription regulators of the MHC II gene and results in development of blind lymphocytes due to the lack of indicatory MHC II molecules. Despite homogeneity of clinical manifestations of patients with MHC II deficiency, the genetic defects underlying this disease are heterogeneous. Read More

    Oral immunotherapy for food allergy: A Spanish guideline. Egg and milk immunotherapy Spanish guide (ITEMS GUIDE). Part 2: Maintenance phase of cow milk (CM) and egg oral immunotherapy (OIT), special treatment dosing schedules. Models of dosing schedules of OIT with CM and EGG.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):508-518. Epub 2017 Jul 1.
    Pediatric Allergy, Department of Medicine, Imperial College London, United Kingdom.
    Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Read More

    Incidence of asthma in young adults from Castellon, Spain: A prospective cohort study.
    Allergol Immunopathol (Madr) 2017 Jul 1. Epub 2017 Jul 1.
    Epidemiologic Division, Public Health Centre, Castellon, Spain; CIBER: Epidemiology and Public Health (CIBERESP), Barcelona, Spain.
    Background: The objective was to estimate the incidence of asthma in young adults from 13-15 years old to 23-25 years old, and associated factors.

    Methods: In 2012, a population-based prospective cohort study was carried out in Castellon from the cohort who had participated in the International Study of Asthma and Allergy in Childhood in 1994 and 2002. A telephone survey was undertaken using the same questionnaires. Read More

    Effects of icariin on asthma mouse model are associated with regulation of prostaglandin D2 level.
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):567-572. Epub 2017 Jun 29.
    Department of Respiratory Medicine, The Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Background: We aimed to observe the effect of icariin on an asthma mouse model and explore the potential underlying mechanisms.

    Methods: The asthma mouse model was established by ovalbumin (OVA) sensitisation and respiratory syncytial virus (RSV) infection and then treated with icariin. Airway resistance was assessed by whole body plethysmograph. Read More

    Bronchopulmonary dysplasia as a risk factor for asthma in school children and adolescents: A systematic review.
    Allergol Immunopathol (Madr) 2017 Jun 28. Epub 2017 Jun 28.
    Pediatric Pulmonology and Allergy Unit, University Hospital La Ribera, Alzira, Valencia, Spain.
    Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that mainly affects extremely pre-term infants, and remains the most common complication of prematurity. Several studies have shown that prematurity predisposes to the development of asthma in school children and adolescents. Nevertheless, it is not clear to what extent a history of BPD involves an additional risk. Read More

    Oral immunotherapy for food allergy: A Spanish guideline. Immunotherapy egg and milk Spanish guide (items guide). Part I: Cow milk and egg oral immunotherapy: Introduction, methodology, rationale, current state, indications contraindications and oral immunotherapy build-up phase.
    Allergol Immunopathol (Madr) 2017 Jul - Aug;45(4):393-404. Epub 2017 Jun 26.
    Pediatric Allergy, Department of Medicine, Imperial College London, United Kingdom.
    Introduction: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Read More

    Helicobacter pylori seropositivity protects against childhood asthma and inversely correlates to its clinical and functional severity.
    Allergol Immunopathol (Madr) 2017 Jun 20. Epub 2017 Jun 20.
    Department of Pediatrics, Ain Shams University, Egypt.
    Background: In recent years, the prevalence of asthma has risen in developed countries, and its extent related to a change in our indigenous microbiota. Helicobacter pylori disappearance across the population represents a fundamental change in our human microbiota and has preceded the rise in asthma prevalence.

    Objective: To assess the relationship between childhood asthma and Helicobacter pylori infection. Read More

    Biomarkers of airway and systemic inflammation in obese asthmatic paediatric patients.
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):534-540. Epub 2017 Jun 20.
    Bagcilar Training and Research Hospital, Clinicis Pediatrics, Istanbul, Turkey.
    Background: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment.

    Objective: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation.

    Methods: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey. Read More

    Does atopy affect the course of viral pneumonia?
    Allergol Immunopathol (Madr) 2017 Jun 17. Epub 2017 Jun 17.
    Marmara University Faculty of Medicine, Department of Pediatric Pulmonology, Istanbul, Turkey.
    Background: The presence of atopy is considered as a risk factor for severe respiratory symptoms in children. The objective of this study was to examine the effect of atopy on the course of disease in children hospitalised with viral pneumonia.

    Methods: Children between the ages of 1 and 6 years hospitalised due to viral pneumonia between the years of 2013 and 2016 were included to this multicentre study. Read More

    A comparison of two clinical scores for bronchiolitis. A multicentre and prospective study conducted in hospitalised infants.
    Allergol Immunopathol (Madr) 2017 Jun 16. Epub 2017 Jun 16.
    Hospital de Sagunto, Avda Ramón y Cajal s.n, Sagunto, 46520 Valencia, Spain.
    Background: There are a number of clinical scores for bronchiolitis but none of them are firmly recommended in the guidelines.

    Method: We designed a study to compare two scales of bronchiolitis (ESBA and Wood Downes Ferres) and determine which of them better predicts the severity. A multicentre prospective study with patients <12 months with acute bronchiolitis was conducted. Read More

    The safety profile of subcutaneous allergen immunotherapy in children with asthma in Hangzhou, East China.
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):541-548. Epub 2017 Jun 17.
    Department of Respiratory Medicine, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:
    Background: The aim of the current study is to evaluate the prevalence, severity and possible risk factors of systemic reactions (SRs) to subcutaneous allergen immunotherapy (SCIT) in children and adolescents with asthma in Hangzhou, east China's Zhejiang province.

    Methods: From January 2011 to December 2016, this survey analysed the SCIT-related SRs involving 429 patients (265 children and 134 adolescents) affected by allergic asthma. Recorded data included demographics, diagnosis, patient statuses, pulmonary function testing results before and after each injection, allergen dosage, and details of SRs. Read More

    Oral immunisation with Taishan Pinus massoniana pollen polysaccharide adjuvant with recombinant Lactococcus lactis-expressing Proteus mirabilis ompA confers optimal protection in mice.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):496-505. Epub 2017 Jun 16.
    Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Shandong Taian 271018, PR China. Electronic address:
    Background: Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals.

    Method: A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. Read More

    Trends in prevalence and risk factors of allergic rhinitis symptoms in primary schoolchildren six years apart in Budapest.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):487-495. Epub 2017 Jun 17.
    Department of Pulmonology, Semmelweis University Budapest, 1/c Diós árok, Budapest H-1125, Hungary.
    Background: Few data are available concerning the time trends and risk factors associated with allergic rhinitis (AR) in schoolchildren in Hungary.

    Methods: At an interval of six years, parents of 6-12-year-old children completed identical ISAAC-based and additional questionnaires related to possible risk factors.

    Results: Response rate was 62. Read More

    Influence of the Mediterranean diet during pregnancy in the development of wheezing and eczema in infants in Pamplona, Spain.
    Allergol Immunopathol (Madr) 2017 Jun 16. Epub 2017 Jun 16.
    Navarra Institute for Health Research (IdiSNA), Spain; Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
    Background: This study examined the relationship between different food groups and the adherence to a Mediterranean diet during pregnancy and the risk of wheezing and eczema in children aged 12-15 months.

    Methods: The study involves 1087 Spanish infants from the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). The study of the association of the different food consumption and Mediterranean diet with wheezing, recurrent wheezing and eczema was performed using different models of unconditional logistic regression to obtain adjusted prevalence odds ratios (OR) and 95% confidence intervals (95% CI). Read More

    The protective role of Helicobacter pylori neutrophil-activating protein in childhood asthma.
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):521-527. Epub 2017 May 31.
    Istanbul University, Department of Medical Microbiology Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address:
    Background: Helicobacter pylori quantity and HP-NAP gene expression were evaluated in the faeces of healthy and asthmatic children.

    Methods: H. pylori DNAs and RNAs were isolated from the stool samples of 92 asthmatic children (AC; 3-8 years) and 88 healthy controls (HC). Read More

    Plasticity of immune system vs. memory therapy IST.
    Allergol Immunopathol (Madr) 2017 Sep - Oct;45(5):482-486. Epub 2017 May 23.
    Dermatology Unit*, NESMOS Department, S. Andrea Hospital, University of Rome "Sapienza", Rome, Italy.
    Background: Pharmacotherapy and immunotherapy are the main treatments for allergic diseases to inhalants.

    Objective: This study investigates whether to repeat short cycles of immunotherapy after 3 or 5 years the from interruption of the first therapeutic cycle, lasting 3-4 years, to maintain immune memory in individuals subjected to IST.

    Methods And Results: We have compared two groups, one of 452 patients who, after the first treatment for 3-4 years of IST, performed a cycle of four months after three and 10 years from the suspension, and a second group of 126 individuals who have performed only the IST treatment for 3-4 years. Read More

    True and false contraindications to vaccines.
    Allergol Immunopathol (Madr) 2017 May 8. Epub 2017 May 8.
    Department of Clinical and Experimental Medicine, Section of Paediatrics UO Pediatria, University of Pisa, via Roma 67, Pisa, Italy.
    Nowadays, the awareness of risks related to infectious diseases has decreased, whereas THE perception of risks related to vaccination is growing. Therefore, it may be difficult for health care providers to convince people of the importance of vaccination and adherence to the immunisation schedule. Selected situations that might raise uncertainties about vaccine recommendations are discussed in order to help health care providers to identify real and perceived contraindications to vaccines, and cases to be referred to specialised pre-vaccination consultation due to an increased risk of adverse events to vaccines. Read More

    Impact of meteorological factors on the emergence of bronchiolitis in North-western Greece.
    Allergol Immunopathol (Madr) 2017 May 5. Epub 2017 May 5.
    Laboratory of Meteorology, Department of Physics, University of Ioannina, Ioannina, Greece.
    Objective: To evaluate the relationship between meteorological factors in North-western Greece and the incidence of bronchiolitis.

    Methods: Meteorological data (air temperature and rainfall) for Ioannina city in North-western Greece and medical data from hospitalised patients at University Hospital of Ioannina were collected between January 2002 and December 2013. The association between meteorological factors and rate of hospitalisation due to bronchiolitis was investigated. Read More

    A rural environment does not protect against asthma or other allergic diseases amongst Mexican children.
    Allergol Immunopathol (Madr) 2017 May 3. Epub 2017 May 3.
    División de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador de Quevedo y Zubieta No. 750, Colonia La Perla, Guadalajara, Jalisco C.P. 44340, Mexico.
    Introduction: The commonly held notion that a rural environment decreases the frequency of allergic diseases has proven to be inconsistent amongst children.

    Objective: Our objective was to contrast the prevalence of bronchial asthma (BA), allergic rhinitis (AR), and atopic dermatitis (AD) between children that live in a rural environment and those that live in urban areas.

    Methods: We carried out a cross-sectional study amongst children aged six to seven; they were selected through probabilistic, stratified and conglomerated sampling. Read More

    Recent thymic emigrants, T regulatory cells, and BAFF level in children with X-linked agammaglobulinaemia in association with chronic respiratory disease.
    Allergol Immunopathol (Madr) 2017 May 3. Epub 2017 May 3.
    Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk Region, Belarus.
    Background: X-linked agammaglobulinaemia (XLA) is a genetic disorder affecting B cell maturation, which is characterised by a low number of B cells, agammaglobulinaemia and increased susceptibility to a variety of bacterial infections. This study was performed to assess T cell subpopulations in a group of children with XLA in association with chronic respiratory disease (CRD).

    Methods: Numbers of T cell subpopulations (CD3+, CD4+, CD8+, CD3+DR+, naïve, memory, recent thymic emigrants (RTE), regulatory T cells, follicular T helpers) were measured by eight-colour flow cytometry in 22 XLA patients and 50 controls. Read More

    Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls?
    Allergol Immunopathol (Madr) 2017 Nov - Dec;45(6):549-552. Epub 2017 Apr 29.
    Acıbadem University Medical Faculty, Pediatrics Unit, Turkey.
    Introduction: There are only a few studies regarding the prevalence of atopy in Familial Mediterranean fever (FMF) patients, and their results are conflicting.

    Methods: In this study children with the diagnosis of FMF were evaluated for the presence of atopy by comparing with controls. One hundred and eighteen children diagnosed as FMF and 50 healthy age and sex matched controls were enrolled. Read More

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