2,995 results match your criteria Allergologia et Immunopathologia [Journal]


Hymenoptera venom allergy among children in Italy: time for pediatricians to take action.

Allergol Immunopathol (Madr) 2020 Jul 8. Epub 2020 Jul 8.

Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

Hymenoptera venom allergy (HVA) is one of the most frequent causes of anaphylaxis following a bee, vespid or ant sting. Real-life data regarding the management of HVA in children are lacking. To address this unmet need, we carried out a survey defining the current management of HVA in children among pediatric allergists in Italy. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.003DOI Listing

Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.

Allergol Immunopathol (Madr) 2020 Jul 8. Epub 2020 Jul 8.

Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Objectives: Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children's Medical Center.

Patients: The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2019.07.012DOI Listing

BCG as a game-changer to prevent the infection and severity of COVID-19 pandemic?

Allergol Immunopathol (Madr) 2020 Jul 3. Epub 2020 Jul 3.

Post Graduate Institute for Medical Education and Research (PGIMER), Chandigarh, India; Department of Pharmacology, India. Electronic address:

The impact of COVID-19 is changing with country wise and depend on universal immunization policies. COVID-19 badly affects countries that did not have universal immunization policies or having them only for the selective population of countries (highly prominent population) like Italy, USA, UK, Netherland, etc. Universal immunization of BCG can provide great protection against the COVID-19 infection because the BCG vaccine gives broad protection against respiratory infections. Read More

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http://dx.doi.org/10.1016/j.aller.2020.05.002DOI Listing

Road toward rapid-molecular point of care test to detect novel SARS-coronavirus 2019 (COVID-19): Review from updated literature.

Allergol Immunopathol (Madr) 2020 Jul 1. Epub 2020 Jul 1.

Rehman College of Allied Health Sciences, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Coronavirus disease 2019 (COVID-19) named by the WHO as a result of the global public health emergency. COVID-19 is caused by a new coronavirus named as novel coronavirus (2019-nCOV). From the first case reported in December 2019 it is now a pandemic situation and a major public health emergency. Read More

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http://dx.doi.org/10.1016/j.aller.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328543PMC

COVID-19 and air pollution: A dangerous association?

Allergol Immunopathol (Madr) 2020 Jul 1. Epub 2020 Jul 1.

Scientific Committee on Air Pollution, Latin American Society of Allergy, Asthma and Immunology, Brazilian Society of Pediatrics, Rio de Janeiro, Brazil; Division of Allergy and Clinical Immunology, Federal University of São Paulo, São Paulo, Brazil.

In late 2019, a new infectious disease (COVID-19) was identified in Wuhan, China, which has now turned into a global pandemic. Countries around the world have implemented some type of blockade to lessen their infection and mitigate it. The blockade due to COVID-19 has drastic effects on the social and economic fronts. Read More

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http://dx.doi.org/10.1016/j.aller.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328542PMC

TREE NUTS ALLERGY: Knowledge, gaps and practical implications.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):313-315

Pediatric Allergy Unit, Severo Ochoa University Hospital, Leganés, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2020.05.001DOI Listing

Improvement of the sensitivity of the detection of Gal d 6-specific IgE via biotinylation in vivo.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):348-354. Epub 2020 Jun 10.

School of Medical Laboratory, Tianjin Medical University, Tianjin, China. Electronic address:

Introduction And Objectives: This study aimed to compare the effects of different biotinylation methods on the performance characteristics of allergen-specific IgE detection.

Materials And Methods: The Gal d 6 gene was cloned into the pAN6/pAC6 vector, resulting in rGal d 6-Bio/Bio-rGal d 6 vector. The fusion protein was expressed in Escherichia coli AVB101 and simultaneously biotinylated in a site-specific manner. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.002DOI Listing

Minimal agreement between basophil activation test and immunoassay in diagnosis of penicillin allergy.

Allergol Immunopathol (Madr) 2020 Jun 9. Epub 2020 Jun 9.

Allergy & Immunology Research Centre, Institute for Medical Research, Ministry of Health Malaysia, Jalan Pahang, 50588, Kuala Lumpur, Malaysia.

Introduction: Basophil activation test (BAT) and immunoassays are the most widely used in vitro tests to diagnose IgE-mediated allergic reactions to penicillin. However, studies to determine if one test is interdependent from another are limited.

Objective: The present study aimed to measure the agreement between BAT and immunoassay in diagnosis of penicillin allergy. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.006DOI Listing

Does delayed urticaria induced by drug allergy exist?

Allergol Immunopathol (Madr) 2020 Jun 3. Epub 2020 Jun 3.

Allergy Unit, Pediatrics Area, Department of Life Sciences and Public Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacred Heart, Rome 00168, Italy. Electronic address:

With the help of a routine clinical case about delayed urticaria induced by drug, we have analyzed the scientific societies reports published during the last 5 years on this topic. We highlighted the differences between the EAACI consensus and documents on drug allergy, commenting their positions and some of their definitions on delayed urticaria. However, the question of disagreement between definitions of delayed urticaria can generate confusion. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.007DOI Listing

The status of FOXP3 gene methylation in pediatric systemic lupus erythematosus.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):332-338. Epub 2020 May 29.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden. Electronic address:

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease caused by interaction of genetic, epigenetic, and environmental factors. One of the important epigenetic factors in SLE would be methylation of immune-related genes, such as FOXP3, which plays a role in activating the regulation and also the function of T cells. To date, the relationship between levels of serum bio-markers and the susceptibility to lupus in children has not been well-understood. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.014DOI Listing

The use of in vivo and in vitro tests in children with beta lactam allergy.

Allergol Immunopathol (Madr) 2020 May 27. Epub 2020 May 27.

Balıkesir University Medical, Faculty Hospital, Department of Pediatrics, Division of Immunology and Allergy Clinic, Balıkesir, Turkey; Department of Pediatrics, Division of Immunology and Allergy Clinic, Izmir, Turkey.

Background: Drug allergies are reactions within the context of drug hypersensitivity reactions, which are caused by immunological mechanisms due to a previously sensitising drug. Beta-lactam antibiotics (BLA) are the leading agents causing drug hypersensitivity reactions in children. The aim of this study is to evaluate the diagnostic importance of in vivo and in vitro diagnostic tests in children with suspected immediate-type BLA hypersensitivity and to investigate the frequency of their use for the final diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.013DOI Listing

Omalizumab treatment in adolescents with chronic spontaneous urticaria: Efficacy and safety.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):368-373. Epub 2020 May 25.

Hacettepe University Faculty of Medicine, Department of Pediatric Allergy, 06100 Ankara, Turkey. Electronic address:

Background: Omalizumab is useful as an add-on treatment in patients unresponsive to high doses of second-generation antihistamines. This study aimed to evaluate the efficacy and safety of omalizumab treatment in adolescents with refractory chronic spontaneous urticaria (CSU).

Methods: CSU patients aged 12-18 years old with the diagnosis of symptomatic CSU and unresponsive to classical treatment were included in the study. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.011DOI Listing

Allergy to beta-lactam antibiotics in children: Risk factors for a positive diagnostic work-up.

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Allergy and Clinical Immunology Department, Centro Hospitalar Universitário de S. João, Porto, Portugal.

Background: Allergy to beta-lactam (βL) antibiotics is highly reported in children, but rarely confirmed. Risk factors for a positive diagnostic work-up are scarce. The primary aim was to characterize the cases of children with confirmed βL allergy, investigating potential risk factors. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.005DOI Listing

Contact haptens in emollients marketed in two European countries (Poland and Spain).

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Department of Pediatric Respiratory Diseases and Allergy, The Medical University of Warsaw, Żwirki i Wigury 63A, PL-02-091 Warsaw, Poland. Electronic address:

Introduction And Objectives: Atopic dermatitis (AD) is the most common skin disease among pediatric patients, which affects up to 20% of children worldwide. Characterized by pruritus and eczema, it is also associated with improper skin barrier function and allergen sensitization. Here, we aimed to assess the presence of haptens in emollients marketed in two European countries: in Poland and Spain, as, firstly, these products are considered to be AD's basic therapy, and, secondly, frequent application of potent sensitizers on atopic skin may result in contact dermatitis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.002DOI Listing

Venom allergy and knowledge about anaphylaxis among beekeepers and their families.

Allergol Immunopathol (Madr) 2020 May 24. Epub 2020 May 24.

Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul, Turkey.

Background: Beekeepers and their families are at an increased risk of life-threatening anaphylaxis due to recurrent bee-sting exposures.

Objective: The aim of this study is to evaluate the demographic features, previous history of anaphylaxis among beekeepers and their family members, and their knowledge about the symptoms and management of anaphylaxis.

Methods: A standardized questionnaire was administered to beekeepers during the 6th International Beekeeping and Pine Honey Congress held in 2018, in Mugla, Turkey. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.008DOI Listing

Seasonal allergic rhinitis and the role of apitherapy.

Allergol Immunopathol (Madr) 2020 May 22. Epub 2020 May 22.

Ortenau Klinikum Offenburg-Kehl, Ebertplatz 12, 77654 Offenburg, Germany.

Background: Apitherapy represents a certain form of complementary and alternative medicine that uses bee products in combination with other methods from this field. One of the basic concepts of this type of medicine is that all diseases can be treated using apitherapy. This study was performed to assess the recommendations from authors of books on apitherapy regarding the treatment of seasonal allergic rhinitis and compare them to findings from the scientific literature. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.015DOI Listing

Comparison of methemoglobin levels in food protein-induced enterocolitis syndrome and other gastrointestinal diseases in neonates.

Allergol Immunopathol (Madr) 2020 May 22. Epub 2020 May 22.

Department of Pediatrics, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.

Introduction And Objectives: Methemoglobinemia has been reported to be associated with severe food protein-induced enterocolitis syndrome (FPIES). However, no reports have evaluated methemoglobin (MHb) levels in FPIES without symptomatic methemoglobinemia or the usefulness of MHb measurement for the diagnostic prediction of FPIES. To evaluate the MHb levels of patients with neonatal-onset FPIES and determine whether MHb levels are higher in FPIES than in other gastrointestinal diseases. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.007DOI Listing

Antihistamines in children and adolescents: A practical update.

Allergol Immunopathol (Madr) 2020 May 21. Epub 2020 May 21.

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Histamine is a chemical mediator, released predominantly by tissue mast cells, circulating basophils, and neurons, which are activated in response to various immunological and non-immunological stimuli. Histamine has to bind to specific receptors to exert its physiological and pathophysiological functions. Endogenous histamine is the main mediator of the immediate allergic response, which moreover, performs other multiple functions, including regulation of gastric secretion, neurotransmission in the central nervous system, and immunomodulatory activity. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.005DOI Listing

Lung disease in patients with common variable immunodeficiency.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

Unidad de Inmunología e Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina.

Background: Common Variable Immunodeficiency (CVID) is characterized by an impaired antibody production and a higher susceptibility to encapsulated bacterial infections. Lung disease is considered to be the most important cause of morbidity and mortality.

Methods: We analyzed clinical, radiological and functional characteristics in 80 patients with CVID assisted in the Unidad Inmunologia e Histocompatibilidad at Durand Hospital from 1982 to 2018. Read More

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http://dx.doi.org/10.1016/j.aller.2020.04.001DOI Listing

Immunogenicity of a new allergoid from Felis domesticus.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

Probelte Pharma S.L.U., S/Antonio Belmonte Abellán, 3-7, 30100 Murcia, Spain.

Background: The chemical modification of allergens with glutaraldehyde improves safety while maintaining clinical efficacy, which permits the administration of higher doses of immunotherapy, reducing the risk of adverse reactions. The aim of this study is to evaluate the immunogenic capacity of a new cat dander polymer by immunizing mice and quantifying immunoglobulins in serum, in comparison with the non-modified allergen.

Methods: The study consists of the immunization of three mice groups with the polymerized and the native extract, together with a negative control group. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.008DOI Listing

Illness perceptions and quality of life in families with child with atopic dermatitis.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Objective: To assess the Quality of Life (QoL) of children with Atopic Dermatitis (AD) and their families and the impact of the mothers' illness perceptions on the family QoL.

Materials And Methods: Seventy-five children with AD (54 infants and 21 children) and their mothers participated in the study. The following questionnaires were administrated: 1. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.003DOI Listing

Autoimmune and inflammatory manifestations in pediatric patients with primary immunodeficiencies and their importance as a warning sign.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

University of Health Sciences Izmir Dr. Behcet Uz Children's Education and Research Hospital, Division of Pediatric Allergy and Immunology, Izmir, Turkey.

Introduction And Objectives: As well as increased susceptibility to infections, autoimmune and inflammatory manifestations also eventuate due to dysregulation of immune system in a substantial proportion of patients with primary immunodeficiency (PID). Autoimmune and inflammatory manifestations can occur prior or after diagnosis of PID. This study aimed to evaluate autoimmune and inflammatory complications among all types of PID patients in childhood and to emphasize the importance of these findings as a warning sign to diagnose PIDs. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.009DOI Listing

Dust mite-derived Enterobacterial fimbriae H protein enforces the allergen specific immunotherapy in asthma mice.

Allergol Immunopathol (Madr) 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen, 518060, China; Guangzhou Institute of Respiratory Diseases, State Key Lab of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China. Electronic address:

Background: The mite alimentary canal contains plenty of microbiota. It is accepted that some of the microbial products function as adjuvants to speed up immune responses.

Objectives: We identified five bacterial proteins from dust mite, and Enterobacterial fimbriae H (FimH) was one of them. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.012DOI Listing

Food allergen sensitization patterns in a large allergic population in Mexico.

Allergol Immunopathol (Madr) 2020 May 19. Epub 2020 May 19.

Medica Sur Clinical Foundation and Hospital, Mexico City, Mexico. Electronic address:

Introduction And Objectives: Although food allergy is recognized as a growing worldwide public health problem, there continues to be limited data on prevalence rates in developing and emerging countries. Most prevalence estimates are based on self-reports, with only few studies using objective assessments. The aim was to analyze the frequency of sensitization to food allergens by serum specific IgE in a large group of unselected allergic patients in Mexico. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.004DOI Listing

Prevalence of asthma, allergic rhinitis and pollinosis in a city of Brazil: A monitoring study.

Allergol Immunopathol (Madr) 2020 May 18. Epub 2020 May 18.

Universidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Patologia, Porto Alegre, RS, Brazil. Electronic address:

Background: Allergic respiratory diseases such as asthma and allergic rhinitis have increased considerably in the last decades.

Objective: The present study estimates prevalence trends of asthma, allergic rhinitis and pollinosis in the population of a city of Southern Brazil, without restriction of age, from 2011 to 2018, using the ISAAC standardized questionnaire.

Methods: Data was collected from March to June of 2011 and during the same months in 2018, in order to verify trends in the prevalence of these allergic conditions. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.010DOI Listing

Perinatal smoking exposure and risk of asthma in the first three years of life: A prospective prebirth cohort study.

Allergol Immunopathol (Madr) 2020 May 18. Epub 2020 May 18.

Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.

Background: There is limited evidence on the association between prenatal smoking exposure and the risk of asthma in children. The aim of this prebirth cohort study was to investigate the association between prenatal and postnatal tobacco smoke exposure and the risk of asthma in Japanese children.

Methods: Study subjects were 1304 mother-child pairs. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.008DOI Listing

Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults.

Allergol Immunopathol (Madr) 2020 May 15. Epub 2020 May 15.

Allergy Department, University Hospital Lozano Blesa, Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.

Introduction: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation.

Objective: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital.

Method: Descriptive, retrospective and cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.009DOI Listing

Tyrophagus putrescentiae group 4 allergen allergenicity and epitope prediction.

Allergol Immunopathol (Madr) 2020 May 14. Epub 2020 May 14.

Department of Clinical Laboratory, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China. Electronic address:

Introduction And Objectives: Allergen-specific immunotherapy (ASIT) is the only allergic disease-modifying therapy available for children and adults, and recombinant allergens are an interesting approach to improve allergy diagnosis and ASIT. Tyrophagus putrescentiae is a common storage mite that produces potent allergens. The aim of this study was to express and characterize recombinant group 4 allergen protein of T. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.006DOI Listing

Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran.

Allergol Immunopathol (Madr) 2020 May 11. Epub 2020 May 11.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Educationan and Research Netwrork (USERN), Tehran, Iran. Electronic address:

Introduction: The prevalence of undiagnosed primary immunodeficiency diseases is remarkably high and contributes to increasing the rate of morbidity and mortality among this group of patients.

Objective: To examine the 10 warning sign scoring system in patients suspected of primary immune deficiency and also estimate the diagnostic delay in patients with proven disease.

Methods: This descriptive cross-sectional study was carried out during the years 2015-2016 in Ali Asghar (AS) Clinic and Hospital. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.005DOI Listing

Predictors of a positive oral food challenge to cow's milk in children sensitized to cow's milk.

Allergol Immunopathol (Madr) 2020 May 10. Epub 2020 May 10.

Paediatric Allergies, Immunology and Pneumology Unit, Paediatric Medicine Service, Parc Tauli University Hospital of Sabadell, Barcelona, Spain.

Introduction And Objectives: The diagnosis of IgE-mediated cow's milk allergy (CMA) is often based on clinical history and on specific IgE levels and/or skin-prick tests (SPT), both of which are sensitive but not specific. The gold standard, oral food challenge (OFC), is expensive and time-consuming and involves a risk of severe allergic reactions. This study aimed to determine the value of specific IgEs, ratios of specific IgEs for cow's milk and its components to total IgE, and wheal size on SPT for predicting a positive OFC for CMA. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.007DOI Listing

Factors associated with wheezing among Lebanese children: Results of a cross-sectional study.

Allergol Immunopathol (Madr) 2020 May 10. Epub 2020 May 10.

INSPECT-LB: Institut National de Santé Publique, Epidémiologie Clinique et Toxicologie - Liban, Beirut, Lebanon; Faculty of Pharmacy, Lebanese University, Beirut, Lebanon; Faculty of Medicine, Lebanese University, Beirut, Lebanon.

Background: In Lebanon, asthma is underdiagnosed due to low access to healthcare, particularly in rural areas, although asthma diagnosis in children is based mainly on clinical symptoms. Thus, wheezing might be more suggestive of undiagnosed respiratory diseases including asthma in Lebanese children. This study aimed to determine the factors associated with wheezing in Lebanese children without asthma diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2020.02.003DOI Listing

Atopic dermatitis incidence and risk factors in young adults in Castellon (Spain): A prospective cohort study.

Allergol Immunopathol (Madr) 2020 May 8. Epub 2020 May 8.

Epidemiology Division, Public Health Center, Castelló de la Plana, Spain; CIBER Salud Pública Epidemiología (CIBERESP), Barcelona, Spain; Department Health Sciences, Universitat Jaume I, Castelló de la Plana, Spain.

Introduction: There are few atopic dermatitis (AD) incidence cohort studies in young adults, the etiology of this disease remains obscure, and AD risk factors in adults are not well understood. The objective of this study was to estimate AD ten-year incidence and prevalence in a cohort of adolescent aged 14-16 at inception in Castellon province in Valencia Region, Spain and describe related risk factors.

Material And Methods: From 2002 to 2012, a population-based prospective cohort study was carried out. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.004DOI Listing

Adverse reaction with hexavalent vaccine: An unusual case.

Allergol Immunopathol (Madr) 2020 May 10. Epub 2020 May 10.

Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.

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http://dx.doi.org/10.1016/j.aller.2020.03.006DOI Listing

LTP allergy/sensitization in a pediatric population.

Allergol Immunopathol (Madr) 2020 May 8. Epub 2020 May 8.

Allergy Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy. Electronic address:

Plant lipid transfer proteins (LTPs) are widespread plant food allergens, highly resistant to food processing and to the gastrointestinal environment, which have been described as the most common food allergens in the Mediterranean area. LTP allergy is widely described in adults, but it represents an emerging allergen also in the pediatric population. Little is known about the real prevalence and the clinical features of this allergy in children and it still often remains underdiagnosed in these patients. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.004DOI Listing

Atopy patch test in children with cow's milk and hen's egg allergy: Do clinical symptoms matter?

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):323-331. Epub 2020 May 10.

Dokuz Eylul University, Division of Pediatric Immunology and Allergy, Izmir, Turkey.

Introduction And Objectives: Since early 2000s, atopy patch test (APT) has been used to determine non-IgE and mixed-type food allergies. Previous studies have reported conflicting results about the diagnostic value of APT in food allergies, due to non-standardized methods. We aimed to determine the diagnostic efficacy of APT compared to open oral food challenge (OFC) in patients diagnosed with cow's milk allergy (CMA) and hen's egg allergy (HEA) manifesting as atopic dermatitis (AD) and gastrointestinal system symptoms. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.002DOI Listing

Disagreement between guidelines regarding the third step of asthma drug therapy for school-age children.

Allergol Immunopathol (Madr) 2020 May 1. Epub 2020 May 1.

Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacred Heart, Rome 00168, Italy.

With the help of a routine clinical case, we highlighted the difference between two of the best asthma guidelines available at the time regarding therapeutic suggestions for the so-called "third step" for school-age asthmatic children. We have analyzed the scientific evidence that each of the two guidelines brings to support their position. Finally, we have motivatedly solved the clinical scenario. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.004DOI Listing

Asthma diagnosis and lung testing: Where is the boundary of asthma?

Authors:
Luis Moral

Allergol Immunopathol (Madr) 2020 May - Jun;48(3):211-213

Pediatric Allergy and Respiratory Unit, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2020.03.001DOI Listing

Network pharmacology-based study of the protective mechanism of conciliatory anti-allergic decoction on asthma.

Allergol Immunopathol (Madr) 2020 Apr 28. Epub 2020 Apr 28.

The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, PR China. Electronic address:

Background: This study aimed to explore the underlying anti-asthma pharmacological mechanisms of Conciliatory Anti-allergic decoction (CAD) with a network pharmacology approach.

Methods: Traditional Chinese medicine related databases were utilized to screen the active ingredients of CAD. Targets of CAD for asthma treatment were also identified based on related databases. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.011DOI Listing
April 2020
1.580 Impact Factor

The MEFV gene and its association with familial Mediterranean fever, severe atopy, and recurrent respiratory tract infections.

Allergol Immunopathol (Madr) 2020 Apr 28. Epub 2020 Apr 28.

Department of Genetic Diseases, Duzen Laboratories Group, Ankara, Turkey.

Background: Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease and is characterized by self-limiting episodes of fever and polyserositis. The aim of this study was to determine the atopic clinical findings associated with the MEFV gene.

Methods: A retrospective chart review was conducted of pediatric patients who had received a diagnosis of familial Mediterranean fever between August 2015 and November 2018. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.010DOI Listing

Activated PI3K-delta syndrome in an Egyptian pediatric cohort with primary immune deficiency.

Allergol Immunopathol (Madr) 2020 Apr 26. Epub 2020 Apr 26.

Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Al Sharqia Governorate, Egypt. Electronic address:

Background: Activated Phospho-Inositide 3 (PI3) Kinases Delta syndrome (APDS) can underlie primary immune deficiency. The prevalence and phenotypic characterization of these patients are not well described in Egypt.

Objectives: To describe patients with APDS in hospitalized children with recurrent respiratory tract infections with suspected primary immune deficiency. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.006DOI Listing

Anti-allergic function of α-Tocopherol is mediated by suppression of PI3K-PKB activity in mast cells in mouse model of allergic rhinitis.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):395-400. Epub 2020 Apr 23.

Department of Otolaryngology, Affiliated ZhangJiaGang Hospital of Soochow University, Suzhou, 215600, China.

Background: Alpha-Tocopherol (α-TCP), one major form of vitamin E, has been known as a treatment for airway allergic inflammation. However, the role and mechanism of α-TCP in treating allergic rhinitis remains unclear.

Objective: In this study we examined the inhibitory function of α-TCP in a mouse model of allergic rhinitis. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.005DOI Listing
April 2020
1.580 Impact Factor

Role of nasal saline irrigation in the treatment of allergic rhinitis in children and adults: A systematic analysis.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):360-367. Epub 2020 Apr 21.

Department of Otolaryngology, Tongji Hospital, Medical College of Tongji University, Shanghai 200065, China. Electronic address:

Background: This meta-analysis aims to access the efficacy of nasal saline irrigation in the treatment of allergic rhinitis (AR) in adults and children.

Methods: Two authors independently searched databases up to December 2018. Differences in efficacy between saline irrigation and other treatments were compared. Read More

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http://dx.doi.org/10.1016/j.aller.2020.01.002DOI Listing

Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy.

Allergol Immunopathol (Madr) 2020 Apr 20. Epub 2020 Apr 20.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Introduction And Objectives: Wheat and cereal grains have a broad range of cross-reactivity, but the clinical relevance of this cross-reactivity is uncertain. This study aimed to evaluate clinical and in vitro cross-reactivity with barley, oat, and Job's tears among wheat-allergic patients.

Materials And Methods: Patients aged 5 to 15 years with IgE-mediated wheat allergy were enrolled. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.008DOI Listing

Reference values of leukocyte and lymphocytes populations in umbilical cord and capillary blood in healthy Mexican newborns.

Allergol Immunopathol (Madr) 2020 May - Jun;48(3):295-305. Epub 2020 Apr 17.

Unidad de Investigación en Inmunodeficiencias, Instituto Nacional de Pediatría, SSa, Ciudad de México, Mexico. Electronic address:

Introduction: In newborns, dramatic changes occur in the blood and bone marrow during the first hours; there are rapid fluctuations in the quantities of leukocytes populations. In this work, we investigated leukocytes subsets counts in two types of blood samples (cord blood and capillary blood) extracted from healthy newborns.

Methods: Blood samples from Mexican neonates were collected by Instituto Nacional de Pediatría with written informed consent. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.009DOI Listing

Predicting the outcome of respiratory disease in wheezing infants using tidal flow-volume loop shape.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):355-359. Epub 2020 Apr 17.

Paediatric Pulmonology Unit, Division of Pediatrics, Pontificia Universidad Católica de Chile, Santiago, Chile.

Introduction And Objectives: Wheezing (RW) infants with a positive asthma predictive index (API+) have a lower lung function as measured by forced expiratory techniques. Tidal flow-volume loops (TFVL) are easy to perform in infants, and sedation is not necessary.

Materials And Methods: A total of 216 wheezing infants were successfully measured, and 183 of them were followed for over a year. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.002DOI Listing

Clinical and immunological features of 44 common variable immunodeficiency patients: The experience of a single center in Turkey.

Allergol Immunopathol (Madr) 2020 Apr 13. Epub 2020 Apr 13.

Division of Pediatric Allergy, Immunology and Infectious Diseases, Department of Pediatrics, Istanbul University Cerrahpaşa Faculty of Medicine, Istanbul, Turkey. Electronic address:

Introduction And Objectives: Common variable immunodeficiency (CVID) is one of the most prevalent forms of primary immunodeficiency characterized by hypogammaglobinemia. Its heterogeneous clinical features include recurrent respiratory tract infections and other complications such as gastrointestinal, autoimmunity, and lymphoproliferative disorders. The aim of this article is to evaluate the general characteristics of CVID patients. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.008DOI Listing

Neutrophil-lymphocyte ratio: a possible marker of remission in children with chronic spontaneous urticaria.

Authors:
S Karaman B Turedi

Allergol Immunopathol (Madr) 2020 May - Jun;48(3):290-294. Epub 2020 Apr 13.

Diyarbakır Children's Hospital, Department of Pediatric Surgery, Diyarbakır, Turkey.

Background: Chronic spontaneous urticaria (CSU) is a disease that seriously disturbs the quality of life of the patient. Currently there is no prognostic marker of the disease. Our aim in this study was to determine possible prognostic markers of CSU in children. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.007DOI Listing

An age-adjusted instruction video enhances the correct use of nasal corticosteroid sprays in children.

Allergol Immunopathol (Madr) 2020 Apr 12. Epub 2020 Apr 12.

Department of Pediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands. Electronic address:

Introduction And Objectives: Allergic rhinitis is a common disorder. Intranasal corticosteroid sprays are used to control symptoms. However, incorrect use of these sprays can decrease efficacy and lead to side effects such as nose bleeding. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.006DOI Listing

Identification of the major allergenic proteins from silkworm moth (Bombyx mori) involved in respiratory allergic diseases.

Allergol Immunopathol (Madr) 2020 Apr 10. Epub 2020 Apr 10.

Programa de Pós-graduação em Saúde da Criança e do Adolescente, Universidade Federal do Paraná, Brazil.

Introduction And Objectives: Moths are a significant source of indoor and outdoor aeroallergens. High prevalence of IgE-mediated sensitization was demonstrated in a group of patients with allergic respiratory diseases. There are no studies on adult stage of these moth species allergens involved in allergic respiratory reactions - the aim of this study. Read More

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http://dx.doi.org/10.1016/j.aller.2019.12.003DOI Listing

Divergent trends in the prevalence of asthma-like symptoms and asthma in a developing country: three repeated surveys between 2002 and 2016.

Allergol Immunopathol (Madr) 2020 Apr 10. Epub 2020 Apr 10.

Department of Medicine and Canadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Canada.

Introduction And Objectives: There have been differences in temporal trends of asthma prevalence by geographic region and economic prosperity. The aim of this study was to assess temporal trends in asthma prevalence among young adolescents in Skopje, Republic of North Macedonia as a developing country with a low asthma prevalence.

Subjects And Methods: Data was obtained from three cross-sectional surveys (2002, 2006, and 2016) of adolescents (12-15 years) from randomly selected schools in Skopje. Read More

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http://dx.doi.org/10.1016/j.aller.2019.11.003DOI Listing