694 results match your criteria Allergologia et Immunopathologia [Journal]


Omalizumab treatment in patients with severe chronic spontaneous urticaria: consideration from real-life experience in Italy.

Authors:
Riccardo Asero

J Dermatolog Treat 2018 Dec 7:1-5. Epub 2018 Dec 7.

a Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

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December 2018

Differences in chronic spontaneous urticaria between Europe and Central/South America: results of the multi-center real world AWARE study.

World Allergy Organ J 2018 16;11(1):32. Epub 2018 Nov 16.

17Novartis Pharma AG, Basel, Switzerland.

Background: Global chronic urticaria (CU) disease experience and management is not well documented. This study descriptively compares these aspects among CU patients residing in Europe (EU) and Central and South America (C/SA).

Methods: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) is a global prospective, non-interventional study of CU in the real-world setting. Read More

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November 2018
1 Read

Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients.

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Background: Chronic spontaneous urticaria (CSU) is defined as spontaneous occurrence of wheals and/or angioedema for ≥6 weeks. Omalizumab is a monoclonal anti-IgE antibody effective in refractory CSU, but its mechanism of action and markers predictive of response remain not completely defined.

Objectives: To correlate baseline levels of two proposed biomarkers, total IgE (bIgE) and d-dimer (bd-dimer), and clinical parameters to omalizumab response and to relapses after drug withdrawal. Read More

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November 2018
6 Reads

Hypersensitivity reactions to non-vitamin K oral anticoagulants - a review of literature and diagnostic work-up proposal.

Eur Ann Allergy Clin Immunol 2018 11 12. Epub 2018 Nov 12.

Ospedale degli Infermi di Rimini, Rimini, Italy.

Summary: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly being used in hospital and outpatient settings as safe alternatives to warfarin. Hypersensitivity reactions have been described for NOACs and can be classified according to Gell and Coombs. We reviewed case reports of possible drug hypersensitivity reactions, noticing a predominance of delayed reactions (both mild and severe) and the absence of cross-reactions to warfarin and low molecu-lar weight heparins. Read More

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November 2018
12 Reads

Down-titration of omalizumab in a patient with chronic spontaneous urticaria.

Authors:
Pinuccia Omodeo

J Dermatolog Treat 2018 Oct 23:1-8. Epub 2018 Oct 23.

a Ambulatorio di Allergologia - SOC Malattie Apparato Respiratorio - Azienda Ospedaliera Santi Antonio a Biagio e Cesare Arrigo , Alessandria , Italy.

This article reports the history of a patient affected by chronic spontaneous urticaria, unresponsive to antihistamines, who received omalizumab, according to a personalized schedule. Prolonged administration of low dosage drug provided a good and long-lasting control of symptoms. This experience suggests that omalizumab could be used at low dose, with personalized plans, to reduce the risk of adverse events and costs of treatment. Read More

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October 2018
2 Reads

Effects of thermal treatment on walnut detection and allergenicity.

J Sci Food Agric 2018 Oct 16. Epub 2018 Oct 16.

S.S Genova, Food Laboratory, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e valle d'Aosta, Genoa, Italy.

Background: Peanuts and tree nut allergies pose an increasing food safety problem. The aim of our study was to test the accuracy of different commercial enzyme-linked immunosorbent assay (ELISA) kits in the detection of the presence of walnuts in untreated and heat exposed food samples. The effects of thermal treatment of samples were evaluated by exposing walnuts to different heat treatments. Read More

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October 2018
1 Read

The role of mobile apps in allergic respiratory diseases: an Italian multicentre survey report.

Eur Ann Allergy Clin Immunol 2018 Nov 15;50(6):268-272. Epub 2018 Oct 15.

Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy.

Summary: We performed a multicentre survey about the role of mobile apps in allergic respiratory diseases. The main objective was to investigate the current use and usefulness of mobile phone apps in the management of allergic respiratory disease. An original questionnaire including 12 multiple-choice questions was administered to 360 participants (153 male and 207 female subjects). Read More

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November 2018
9 Reads

A simple treatment for a potentially life-threatening cause of malabsorption.

Intern Emerg Med 2018 Oct 1. Epub 2018 Oct 1.

Dipartimento di Medicina Interna, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, UOC di Medicina Interna Allergologia Immunologia, Milan, Italy.

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October 2018
1 Read

Evidence of Cross-Reactivity between Different Seed Storage Proteins from Hazelnut (Corylus avellana) and Walnut (Juglans regia) Using Recombinant Allergen Proteins.

Int Arch Allergy Immunol 2018 Sep 13:1-4. Epub 2018 Sep 13.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Seed storage proteins are extremely stable allergens in nuts, seeds, and legumes and are responsible for the most severe allergic reactions to these foods. The cross-reactivity between seed storage proteins from different sources has not been studied at a molecular level so far. This study aimed to ascertain the cross-reactivity between walnut and hazelnut seed storage proteins using recombinant allergens. Read More

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September 2018
21 Reads
2.670 Impact Factor

Hymenoptera Venom Allergy: Management of children and adults in clinical practice.

J Investig Allergol Clin Immunol 2018 Sep 5. Epub 2018 Sep 5.

Complex Unit of Allergology and Immunology at ASST Grande Ospedale Metropolitano Niguarda - School of Specialization in Allergology and Clinical Immunology at University of Milan, Italy.

Hymenoptera venom allergy is an epidemiologically underestimated condition representing an important cause of morbidity worldwide. Preventing future allergic reactions in patients who have developed a systemic reaction is based on the correct management of emergency followed by a correct diagnosis, prescription of adrenaline autoinjectors and, where indicated, specific venom immunotherapy (VIT). Some epidemiological studies highlight the poor knowledge of this disease and the frequent inadequacy of its management. Read More

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September 2018

Mitochondrial ribosomal proteins involved in tellurite resistance in yeast Saccharomyces cerevisiae.

Sci Rep 2018 Aug 13;8(1):12022. Epub 2018 Aug 13.

Istituto di Bioscienze e BioRisorse-UOS Portici-CNR c/o Dipartimento di Biologia, Sezione di Igiene, Via Mezzocannone 16, Napoli, 80134, Italy.

A considerable body of evidence links together mitochondrial dysfunctions, toxic action of metalloid oxyanions, and system and neurodegenerative disorders. In this study we have used the model yeast Saccharomyces cerevisiae to investigate the genetic determinants associated with tellurite resistance/sensitivity. Nitrosoguanidine-induced KTeO-resistant mutants were isolated, and one of these mutants, named Sc57-Te, was characterized. Read More

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Elevated IgE to tissue factor and thyroglobulin are abated by omalizumab in chronic spontaneous urticaria.

Allergy 2018 Aug 4. Epub 2018 Aug 4.

UOC Dermatologia, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.

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August 2018
8 Reads

Fatal asthma after omalizumab and controller therapy discontinuation.

Eur Ann Allergy Clin Immunol 2018 Jul 24;50(5):235-236. Epub 2018 Jul 24.

Allergy and Respiratory Diseases, University of Genoa, Genova, Italy.

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July 2018
6 Reads

Severe asthma in adolescents and adults: a national, multicenter registry in real life.

Eur Ann Allergy Clin Immunol 2018 Sep 24;50(5):196-201. Epub 2018 Jul 24.

Unità Operativa Complessa di Pneumologia, ASST-Rhodense , Garbagnate Milanese (MI), Italy.

Summary: The number of patients with uncontrolled asthma is growing especially in young people. Although current therapies improve the disease management, the heterogeneity of clinical outcomes results in patients whose asthma is refractory to standard therapies. To understand not responsive phenotypes, we instituted a web-registry aimed to collect real life data of adolescent and adult patients. Read More

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September 2018
1 Read

An atlas of IgE sensitization patterns in different Italian areas. A multicenter, cross-sectional study.

Eur Ann Allergy Clin Immunol 2018 Sep 24;50(5):217-225. Epub 2018 Jul 24.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.

Summary: The development of recombinant technology supported the allergy diagnostic work-up in the daily clinical practice, representing a useful tool for epidemiological studies. An atlas of the IgE sensitization profiles found throughout Italy was prepared from a nationwide, multicenter, cross-sectional study. 6052 unselected consecutive individuals, belonging to North-West [NW], North-East [NE], Centre [C], South [S], and Islands subset [Is] were evaluated by means of the ImmunoCAP ISAC test. Read More

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September 2018
1 Read

Efficacy of omalizumab 150 mg/month as a maintenance dose in patients with severe chronic spontaneous urticaria showing a prompt and complete response to the drug.

Authors:
Riccardo Asero

Allergy 2018 Nov 8;73(11):2242-2244. Epub 2018 Aug 8.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, MI, Italy.

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November 2018
6 Reads

House dust mite-related respiratory allergies and probiotics: a narrative review.

Clin Mol Allergy 2018 19;16:15. Epub 2018 Jun 19.

Allergy Therapeutics Italia, via IV Novembre 76, 20019 Settimo Milanese, Milan Italy.

The socio-economic burden of allergic respiratory conditions on continental Europe is even higher than that of mainstream diseases, such as diabetes and cardiovascular disease, as allergic rhinitis alone accounts for billions of Euros in healthcare expenses across Europe. House dust mites (HDM) are one of the most common triggers behind allergic rhinitis and asthma. The role of probiotics in the treatment and prevention of some allergic conditions, such as atopic dermatitis, is already well recognized, whereas evidence about their efficacy in patients with respiratory allergies-while increasing-is still limited. Read More

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June 2018
1 Read

[New in vitro allergological diagnostic tool and its application in professional disease.]

G Ital Med Lav Ergon 2017 Nov;39(3):278-284

Unità operativa Dipartimentale di Allergologia Ospedale G. Da Saliceto Ausl Piacenza.

Objectives: Molecular diagnostic is a new therapeutic approach that - allows to valuate sensitization towards a single molecule in a allergenic source and to obtain relevant information on clinical features: sensitization towards molecules as alfa amylase of wheat or lipocalins of pets, Alt a 1 of alternaria spores and Hev b 6 of latex correlates with the risk to develop asthma - has a greater sensitivity in the serum IgE identification than the whole source. Read More

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November 2017
1 Read

Use of omalizumab in uncontrolled chronic spontaneous urticaria also improved latex induced contact urticaria.

J Allergy Clin Immunol Pract 2018 May 23. Epub 2018 May 23.

Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy. Electronic address:

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May 2018
1 Read

Aedes communis Reactivity Is Associated with Bee Venom Hypersensitivity: An in vitro and in vivo Study.

Int Arch Allergy Immunol 2018 22;176(2):101-105. Epub 2018 May 22.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Mosquito bite is usually followed by a local reaction, but severe or systemic reaction may, in rare cases, occur. Allergic reactions to Aedes communis (Ac) may be underestimated due to the lack of reliable diagnostic tools. In this multicenter study, 205 individuals reporting large local reactions to Ac were enrolled and studied for cutaneous or IgE reactivity to Ac, Blattella germanica, Penaeus monodon, and Dermatophagoides pteronyssinus. Read More

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June 2018
14 Reads
2.670 Impact Factor

Non-Invasive Mechanical Ventilation in Critically Ill Trauma Patients: A Systematic Review.

Turk J Anaesthesiol Reanim 2018 Apr 1;46(2):88-95. Epub 2018 Apr 1.

Hospital Morales Meseguer, Intensive Care Unit, Murcia, Spain.

There is limited literature on non-invasive mechanical ventilation (NIMV) in patients with polytrauma-related acute respiratory failure (ARF). Despite an increasing worldwide application, there is still scarce evidence of significant NIMV benefits in this specific setting, and no clear recommendations are provided. We performed a systematic review, and a search of clinical databases including MEDLINE and EMBASE was conducted from the beginning of 1990 until today. Read More

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April 2018
2 Reads

Extended IgE profile based on an allergen macroarray: a novel tool for precision medicine in allergy diagnosis.

World Allergy Organ J 2018 26;11(1). Epub 2018 Apr 26.

1Personalized Medicine, Asthma and Allergy Unit, Humanitas Clinical and Research Center, 20089 Rozzano MI, Italy.

Background: Precision medicine (PM) is changing the scope of allergy diagnosis and treatment. An in vitro IgE assay, a prototype PM method, was developed in the sixties and has garnered increasing interest because of the introduction of recombinant components in the test. More recently, microarrays of allergen components have significantly improved the ability to describe the IgE profile. Read More

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April 2018
10 Reads

Evaluating children with suspected allergic reactions to vaccines for infectious diseases.

Allergy Asthma Proc 2018 May;39(3):177-183

Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy.

Background: Vaccines often contain potentially allergenic material in addition to pathogen-specific immunogens that may induce allergic reactions. Parents and physicians often suspect that adverse reactions to vaccines are allergic in etiology. The concern that some of the substances contained in vaccines may trigger an anaphylactic reaction may lead to a low vaccination adherence with emergence of infectious disease epidemics. Read More

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May 2018
7 Reads

The complex alteration in the network of IL-17-type cytokines in patients with hereditary angioedema.

Clin Exp Med 2018 Aug 6;18(3):355-361. Epub 2018 Apr 6.

Dipartimento Immunologia Allergologia, Istituto Medico Europeo (ISME), Palermo, Italy.

Hereditary angioedema (HAE) is a rare autosomic-dominant disorder characterized by a deficiency of C1 esterase inhibitor which causes episodic swellings of subcutaneous tissues, bowel walls and upper airways that are disabling and potentially life-threatening. We evaluated n = 17 patients with confirmed HAE diagnosis during attack and remission state and n = 19 healthy subjects. The samples were tested for a panel of IL (Interleukin)-17-type cytokines (IL-1β, IL-6, IL-10, granulocyte-macrophage colony stimulating factor (GM-CSF), IL-17, IL-21, IL-22, IL-23) and transforming growth factor-beta (TGF-β) subtypes. Read More

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August 2018
1 Read

IgE and D-dimer baseline levels are higher in responders than nonresponders to omalizumab in chronic spontaneous urticaria.

Br J Dermatol 2018 Sep 26;179(3):776-777. Epub 2018 Jun 26.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

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September 2018

New scientific synergies to manage patients with severe Rhinitis: allergy diagnosis and treatment for ENT specialists.

J Biol Regul Homeost Agents 2018 Jan-Feb;32(1 Suppl. 1)

Master of “Rino-Allergologia Pratica”, Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy.

Introduction: Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently concerns about 30% of the world’s population. Although AR is not a disease that reduces the life expectancy, it is a disorder with a major impact on the quality of life of patients, resulting from an impaired social life, school performance and work productivity. Furthermore, AR produces significant costs for its treatment. Read More

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Allergy to LTP: to eat or not to eat sensitizing foods? A follow-up study.

Eur Ann Allergy Clin Immunol 2018 Jul 16;50(4):156-162. Epub 2018 Feb 16.

UOC Medicina Generale - Immunologia e Allergologia, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Summary: Follow-up data about the onset of novel food allergies in patients allergic to lipid transfer protein (LTP) are missing. We investigated the occurrence of novel allergies over time in LTP hypersensitive patients. Sixty-seven LTP-allergic patients recommended to avoid foods responsible for systemic reactions and encouraged to eat other sensitizing foods avoiding the association with known co-factors, were re-evaluated after ≥ 1 year to assess the occurrence of allergy to novel foods. Read More

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July 2018
6 Reads

Storage molecules from tree nuts, seeds and legumes: relationships and amino acid identity among homologue molecules.

Eur Ann Allergy Clin Immunol 2018 Jul 1;50(4):148-155. Epub 2018 Feb 1.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Summary: The families of seed storage proteins, together with profilins, oil-bodies-associated oleosins, and pathogenesis-related (PR) proteins like PR-10 (Bet v 1-like), PR-12 (defensins) and PR-14 (non-specific lipid transfer protein), are the main causes of IgE sensitization to tree nuts, legumes and seeds. All these allergens, with the exclusion of profilins and of PR-10, are heat-stable and possibly responsible for fatal or almost fatal adverse reactions to such foods. In this short review, we will discuss the relationship and amino acid identities among some of the seed storage homologue molecules identified to date from tree nuts, seeds and legumes. Read More

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July 2018
3 Reads

Cross-Reactivity and Tolerability of Cephalosporins in Patients with IgE-Mediated Hypersensitivity to Penicillins.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1662-1672. Epub 2018 Feb 3.

Allergy Unit, Presidio Columbus, Rome, Italy.

Background: Studies performed since 1990 on samples of at least 30 subjects with a documented IgE-mediated hypersensitivity to penicillins have found a rate of positive responses to allergy tests with cephalosporins ranging from 0% to 27%.

Objective: We sought to assess the cross-reactivity with cephalosporins and evaluate the possibility of using cephalosporins in penicillin-allergic subjects.

Methods: We conducted a prospective study of 252 consecutive subjects who had suffered 319 immediate reactions (mostly anaphylaxis) to penicillins and had positive skin tests to at least 1 penicillin reagent. Read More

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February 2018
4 Reads

Restoration of aspirin tolerance following omalizumab treatment in a patient with chronic spontaneous urticaria.

Authors:
R Asero

Eur Ann Allergy Clin Immunol 2018 Sep 30;50(5):226-228. Epub 2017 Nov 30.

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.

Summary: Up to 30% of cases of chronic spontaneous urticaria (CSU) are exacerbated by COX-1 inhibiting nonsteroidal anti-inflammatory drugs (NSAID); this clinical picture is termed NECD (NSAID-exacerbated cutaneous disease). On the other hand, multiple NSAID hypersensitivity may occur in the absence of an underlying CSU also, a situation that is termed NIUA (NSAID-induced urticaria / angioedema). The present study reports a case of multiple NSAID hypersensitivity that occurred in a man much before he developed severe CSU. Read More

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September 2018
6 Reads

Recommendations for the use of molecular diagnostics in the diagnosis of allergic dis-eases.

Eur Ann Allergy Clin Immunol 2018 Mar 27;50(2):51-58. Epub 2017 Nov 27.

Servizio di Allergologia, Casa della Salute di Scilla, Scilla (RC), Italy. Associazione Italiana degli Allergologi e Immunologi Territoriali e Ospedalieri (AAIITO).

Summary: The Study Group on Allergology of the Italian Society of Clinical Pathology and Laboratory Medicine (SIPMeL) and the Associazione Italiana degli Allergologi e Immunologi Territoriali e Ospedalieri (AAIITO) developed the present recommendations on the diagnosis of allergic diseases based on the use of molecular allergenic components, whose purpose is to provide the pathologists and the clinicians with information and algorithms enabling a proper use of this second-level diagnostics. Molecular diagnostics allows definition of the exact sensitization profile of the allergic patient. The methodology followed to develop these recommendations included an initial phase of discussion between all the components to integrate the knowledge derived from scientific evidence, a revision of the recommendations made by Italian and foreign experts, and the subsequent production of this document to be disseminated to all those who deal with allergy diagnostics. Read More

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March 2018
3 Reads

An unusual case of wheat dependent exercise induced anaphylaxis (WDEIA) triggered by Tri a 14 in a pediatric patient: a case report.

Eur Ann Allergy Clin Immunol 2018 Jul 23;50(4):187-189. Epub 2017 Nov 23.

UOC Pediatria e Neonatologia, Ospedale Guglielmo da Saliceto, Piacenza, Italia.

Summary: Anakinra, one of the novel biological agents, is a recombinant human IL-1 receptor antagonist. It is preferred as an alternative drug for familial Mediterranean fever cases where colchicine is not sufficient or cannot be used due to its side effects. Like all other biologics, hypersensitivity reactions to anakinra are quite rare. Read More

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July 2018
11 Reads

Autoimmunity and Gastric Cancer.

Int J Mol Sci 2018 Jan 26;19(2). Epub 2018 Jan 26.

Immunologia e Allergologia, Presidio Ospedaliero S. Maria degli Angeli, 33170 Pordenone, Italy.

Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Read More

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January 2018
3 Reads

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria.

Allergy 2018 Jul;73(7):1393-1414

Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charité, Berlin, Germany.

This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. Read More

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July 2018
55 Reads

Comparative study between obstetric antiphospholipid syndrome and obstetric morbidity related with antiphospholipid antibodies.

Med Clin (Barc) 2018 Sep 20;151(6):215-222. Epub 2017 Dec 20.

AP-HP, Hôpital Saint-Antoine, service de médecine interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC Univ Paris 06, F-75012, Paris, France.

Background And Objectives: To compare clinical, laboratory, treatment and live birth rate data between women with aPL-related obstetric complications (OMAPS) not fulfilling the Sydney criteria and women fulfilling them (OAPS).

Materials And Methods: Retrospective and prospective multicentre study. Data comparison between groups from The European Registry on Antiphospholipid Syndrome included within the framework of the European Forum on Antiphospholipid Antibody projects. Read More

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September 2018
46 Reads

Galactose-α-1,3-galactose syndrome: an Italian survey.

Eur Ann Allergy Clin Immunol 2017 Nov;49(6):263-269

Ambulatorio di Allergologia, Clinica S. Carlo, Paderno Dugnano, Milan, Italy.

Summary: The term of α-Gal syndrome, which includes the delayed allergy to red meat and the allergic reactions following the administration of cetuximab, is associated to the presence of specific IgE to α-Gal. In Italy, only anecdotal cases were reported so far. The Association of Italian Allergists (AAITO) carried out a survey with the aim of evaluating presence, characteristics, clinical features, and distribution of the syndrome in Italy. Read More

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November 2017
14 Reads

Perspectives in allergen immunotherapy: 2017 and beyond.

Allergy 2018 Jan;73 Suppl 104:5-23

Department for Pediatric Pneumology and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

The Future of the Allergists and Specific Immunotherapy (FASIT) workshop provides a regular platform for global experts from academia, allergy clinics, regulatory authorities and industry to review developments in the field of allergen immunotherapy (AIT). The most recent meeting, held in February 2017, had two main themes: advances in AIT and hot topics in AIT from the regulatory point of view. The first theme covered opportunities for personalized AIT, advances in adjuvants and delivery systems, and the development of new molecules and future vaccines for AIT. Read More

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January 2018
12 Reads

The clinical relevance of lipid transfer protein.

Clin Exp Allergy 2018 Jan 1;48(1):6-12. Epub 2017 Dec 1.

UOC Immunologia e Allergologia, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

Despite a huge number of studies, many aspects of the lipid transfer protein (LTP) syndrome, the most frequent primary food allergy in Mediterranean countries, remain unclear. Its peculiar geographical distribution, along with the extreme variability of its clinical expression, makes this type of food allergy something unique in the panorama of IgE-mediated food-induced allergic reactions. This review article tried to summarize the current knowledge about the most important aspects of LTP sensitization and allergy, along with the importance of positive and negative co-factors in the clinical expression of the syndrome as well as the issues regarding the cross-reactivity between LTPs present in botanically related and unrelated foods. Read More

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January 2018
1 Read

CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report.

Clin Transl Allergy 2017 23;7:37. Epub 2017 Oct 23.

EC-CNECT-H2, European Commission, Brussels, Belgium.

A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices. Read More

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October 2017
9 Reads

Towards a better categorization of patients with chronic urticaria.

Authors:
R Asero

Br J Dermatol 2017 10;177(4):903-904

Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.

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October 2017
2 Reads

Autoimmune comorbidity in chronic spontaneous urticaria: A systematic review.

Autoimmun Rev 2017 Dec 14;16(12):1196-1208. Epub 2017 Oct 14.

Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergology, Charitéplatz 1, Berlin D-10117, Germany. Electronic address:

Background And Objective: Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa.

Methods: A Pubmed and Google Scholar search was performed to identify studies reporting the prevalence of various AIDs in CSU and vice versa published before April 2017. Read More

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December 2017
14 Reads

Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy.

Allergy 2018 Mar 24;73(3):549-559. Epub 2017 Nov 24.

Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.

Background: Component-resolved diagnosis (CRD) has revealed significant associations between IgE against individual allergens and severity of hazelnut allergy. Less attention has been given to combining them with clinical factors in predicting severity.

Aim: To analyze associations between severity and sensitization patterns, patient characteristics and clinical history, and to develop models to improve predictive accuracy. Read More

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March 2018
8 Reads

An effective algorithm for the serological diagnosis of idiopathic inflammatory myopathies: The key role of anti-Ro52 antibodies.

Clin Chim Acta 2017 Dec 3;475:15-19. Epub 2017 Oct 3.

Laboratorio di Patologia Clinica, Ospedale San Antonio, Tolmezzo, Italy.

Background: Patients with suspected idiopathic inflammatory myopathies (IIM) are commonly tested for the presence of anti-nuclear antibodies (ANA) by indirect immunofluorescence (IIF) on HEp-2 cell substrates. However, ANA-IIF false negative tests may occur in IIM because some antigens, such as Jo1 and Ro52, may be scarcely expressed on HEp-2 cells. In addition, cytoplasmic staining is often not appropriately investigated by a specific antibody assay, leading to decreased clinical sensitivity of the ANA test. Read More

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December 2017
14 Reads

Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective.

Curr Opin Allergy Clin Immunol 2017 Dec;17(6):453-459

aAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano bPersonalized Medicine Asthma and Allergy Clinic, Humanitas Research Hospital, Humanitas University, Rozzano, Milan cDepartment of Dermato-Allergology, San Gallicano Dermatological Institute, IRCCS, Rome dDepartment of Medical Sciences, Dermatologic Clinic, University of Turin, Turin eSection of Dermatology and Venereology, Department of Medicine, University of Verona, Verona fUnità Operativa di Dermatologia, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan gDepartment of Allergy and Clinical Immunology, University of Bari, Bari hDermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena iUnit of Dermatology, Department of Biomedical, Surgical, and Dental Sciences, IRCCS Galeazzi Hospital, University of Milan, Milan jSOD Immunoallergologia Azienda Ospedaliero Universitaria Careggi, Firenze, Italy.

Purpose Of Review: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU.

Recent Findings: Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients. Read More

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December 2017
16 Reads

Elevated baseline D-dimer plasma levels are associated with a prompt response to omalizumab in patients with severe CSU.

J Allergy Clin Immunol Pract 2017 Nov - Dec;5(6):1740-1742. Epub 2017 Aug 31.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Medicina Interna, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.

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August 2017
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