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    2770 results match your criteria Allergologia et Immunopathologia [Journal]

    1 OF 56

    Is food protein induced enterocolitis syndrome only a non IgE-mediated food allergy?
    Allergol Immunopathol (Madr) 2018 Feb 19. Epub 2018 Feb 19.
    Allergy Unit, Department of Pediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    Food protein induced enterocolitis syndrome (FPIES) is classified as non-IgE-mediated or cell-mediated food allergy, although there is an atypical phenotype so defined for the presence of specific IgEs. All diagnostic criteria for FPIES include the absence of skin or respiratory symptoms of IgE-mediated type. We present four cases that suggest that specific IgEs may have a pathogenic role, resulting in the existence of different FPIES phenotypes. Read More

    Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Psicología Clínica, Eulogio Parra No. 2330-301, Col. Las Américas, C.P. 44650, Guadalajara, Jalisco, Mexico.
    Introduction: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent.

    Objective: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children.

    Method: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. Read More

    Increase of natural killer cells in children with liver transplantation-acquired food allergy.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Allergy Unit, Department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
    Background: Transplantation-acquired food allergies (TAFA) are frequently reported and considered to be caused by immunosuppressive therapy. The aim of this study was to investigate the allergic and immunologic responses in children who had liver or kidney transplantations.

    Methods: Twelve children receiving liver transplantations and 10 children receiving kidney transplantations were investigated. Read More

    Evaluation of an intervention to improve the management of allergens in school food services in the city of Barcelona.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Agència de Salut Pública de Barcelona (ASPB, Public Health Agency of Barcelona), Pl Lesseps 1, 08023 Barcelona, Spain. Electronic address:
    Background: An intervention to promote the development of an allergen control plan (ACP) and preventive measures for the management of allergens in school food services was implemented in all schools of Barcelona city over a three-year period (2013-2015) by the public health services. The present study aimed to assess changes regarding the management of food allergens in school food services in Barcelona after an intervention conducted by the public health services of the city.

    Methods: School meal operators of a random sample of 117 schools were assessed before and after the intervention using a structured questionnaire. Read More

    Diagnostic criteria for acute food protein-induced enterocolitis syndrome. Is the work in progress?
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergic disorder. Some diagnostic criteria have been published for acute FPIES. Of course, they are not all the same, so the clinician must choose which ones to adopt for his/her clinical practice. Read More

    Effect of inhaled medication on dental caries index in asthmatic children.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):196-200
    Dentist, Private Practitioner, Shiraz, Iran. Electronic address:
    Introduction: Asthma is a chronic inflammatory disease of airways with a high prevalence among children in pre-school ages. Considering controversial results in different studies about the effect of this disease on the indices of dental caries, the aim of this study was to compare dmft (decay, missing, filling teeth) situation in asthmatic and non-asthmatic 6-12-year-old children.

    Methods: This was a case-control study on 46 asthmatic and 47 non-asthmatic children aged 6-12 years. Read More

    The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis.
    Allergol Immunopathol (Madr) 2018 Feb 2. Epub 2018 Feb 2.
    Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
    Allergic rhinitis, as an allergic and nasal hypersensitivity disease, is associated with the inflammation of nasal mucosa. It appears that innate immune receptors are the important risk factors in the pathogenesis of the inflammatory disease. Toll-like receptors (TLRs) are the most important receptors of innate immunity; their crucial roles in the recognition of allergens and subsequently pathogenesis of allergic diseases have been evaluated recently. Read More

    Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts.
    Allergol Immunopathol (Madr) 2018 Jan 27. Epub 2018 Jan 27.
    Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:
    Background: Hypersensitivity reactions to pine nuts in children have been occasionally encountered recently, although reports on pine nut allergy cases are rare worldwide. The study aimed to feature clinical and laboratory findings pertaining to pine nut allergy in Korean children.

    Methods: Forty-two subjects were enrolled through a retrospective review of medical records, from September 2010 to December 2015, at the Department of Pediatrics in Ajou University Hospital. Read More

    Haploidentical stem cell transplantation in a boy with chronic granulomatous disease.
    Allergol Immunopathol (Madr) 2018 Jan 16. Epub 2018 Jan 16.
    Pediatric Hematology & Oncology Department, Hospital Clínico Universitario de Santiago, Spain.
    Chronic granulomatous disease is a primary immunodeficiency caused by mutations in any one of the five components of the NADPH oxidase in phagocytic leucocytes. This causes impaired microbial killing, which leads to severe life-threatening bacterial and fungal infections. Currently, allogenic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for chronic granulomatous disease, although gene therapy may provide a new therapeutic option for the treatment of patients with CGD. Read More

    Fluticasone in mild to moderate atopic dermatitis relapse: A randomized controlled trial.
    Allergol Immunopathol (Madr) 2018 Jan 17. Epub 2018 Jan 17.
    CS Auxiliar El Vedat de Torrent, Valencia, Spain.
    Background: The long-term efficacy of corticosteroids to prevent atopic dermatitis (AD) relapses has partially been addressed in children. This study compared an intermittent dosing regimen of fluticasone propionate (FP) cream 0.05% with its vehicle base in reducing the risk of relapse in children with stabilized AD. Read More

    Immunomodulation of allergic response in children and adolescents: What we can learn from lymphatic filarial infection.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):167-174. Epub 2018 Feb 1.
    Centro de Pesquisas em Alergia e Imunologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil; Postgraduate Program in Health Sciences, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
    Background: Although it is well known that allergic diseases involve a strong Th2 immune response, with production of high levels of specific IgE allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce.

    Objective: To evaluate the allergic response patterns in cases of filarial infection by comparing peripheral eosinophils, total IgE levels, immediate hypersensitivity and cytokine levels in children and adolescents in Brazil.

    Methods: This was an exploratory study with three groups: (I) with filarial infection and without allergic diseases; (II) without filarial infection and with allergic diseases; and (III) without filarial infection and without allergic diseases. Read More

    Development and characterization of an allergoid of cat dander for immunotherapy.
    Allergol Immunopathol (Madr) 2018 Jan 13. Epub 2018 Jan 13.
    Probelte Pharma S.L.U., Spain.
    Background: Allergy to cats is a frequent cause of sensitization to indoor allergens and currently there are few alternatives to specific immunotherapy with cat native extracts. The objective is to develop and characterize a new allergoid to increase the tools available for use in clinical practice.

    Methods: The allergoid cat dander extract (ACD) was developed from a native cat dander extract (NCD) by modification with glutaraldehyde, and the optimal process control was determined by SDS-PAGE, DOT BLOT and determination of free amine groups. Read More

    The role of regulatory RNAs (miRNAs) in asthma.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):201-205. Epub 2018 Jan 17.
    Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
    Introduction: Recently, a great deal of attention has been paid to the investigation of regulatory functions of microRNA. Currently, many different mechanisms involved in the pathogenesis of asthma are known, but the whole picture of pathogenesis has not yet been studied.

    Conclusions: MicroRNAs play an important role in the regulation of many cellular processes. Read More

    Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    GACE Group Research Associate, Universidad de Antioquia, Colombia; Clinical Allergist IPS Universitaria - Universidad de Antioquia, Colombia. Electronic address:
    Vernal keratoconjunctivitis is one of the most serious ocular allergies that have the potential to induce large ocular morbidity and significant visual changes affecting the quality of life of these individuals.

    Methodology: This study was conducted in two phases. The first phase consisted of the clinical characterization of 32 patients from the Clinical Allergology center of the I. Read More

    Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    Department of Paediatrics, Imperial College London, London, UK.
    Background: Obstructive respiratory disorders, such as allergic rhinitis and asthma may impair sleep quality. The aim of this study is to validate the Children's Sleep Habits Questionnaire (CSHQ) for Greek children from 6 to 14 years of age. No validated tool has been developed so far to assess sleep disturbances in Greek school-aged children. Read More

    Loss of tolerance for fishes previously tolerated in children with fish food protein induced enterocolitis syndrome.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    Department of Pediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    We describe two case reports presenting some novel information on fish FPIES. Fish FPIES to one fish does not always start at the same time to other fish. Additionally, development of tolerance to the index fish do not necessarily imply tolerance to other reactive fish. Read More

    Knowledge on asthma, food allergies, and anaphylaxis: Assessment of elementary school teachers, parents/caregivers of asthmatic children, and university students in Uruguaiana, in the state of Rio Grande do Sul, Brazil.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of Sâo Paulo, SP, Brazil. Electronic address:
    Introduction: Allergic diseases have become an increasingly common reality in the last years, extending beyond the family context.

    Objective: Assessing the level of knowledge on asthma, food allergies and anaphylaxis of asthmatic children's parents/caregivers (PC), elementary school teachers (EST) and university students (US) in Uruguaiana, RS, Brazil.

    Method: 577 individuals (PC - N=111; EST - N=177; US - N=299) took part in the study, answering the Newcastle Asthma Knowledge Questionnaire (validated for Portuguese) and another questionnaire on Food Allergy (FA) and anaphylaxis. Read More

    Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):181-189. Epub 2018 Jan 12.
    Histology Department, Valladolid University, Spain.
    Background: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is not a clear etiologic treatment. Biopsies analysis using plant histology methods may show callose and pollen tubes in the esophageal mucosa. Read More

    Small-airway dysfunction precedes the development of asthma in children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    Pediatric Pulmonology and Allergy Unit, Department of Pediatrics, University of Patras Medical School, Patras, Greece.
    Background: Epidemiological evidence suggests the existence of a direct link between allergic rhinitis (AR) and asthma. Several studies also support the presence of small-airway dysfunction (SAD) in non-asthmatic children with AR. However, it remains unknown whether SAD can predict the progression of AR to asthma. Read More

    Mycoplasma pneumoniae and toll-like receptors: A mutual avenue.
    Allergol Immunopathol (Madr) 2018 Jan 10. Epub 2018 Jan 10.
    Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran. Electronic address:
    Mycoplasma pneumoniae is an intracellular bacterium leading to several complications in humans. M. pneumoniae is cleared in some cases and induces complications in others. Read More

    Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):107-111. Epub 2018 Jan 11.
    Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, Beijing 100020, China. Electronic address:
    Background: The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare.

    Objective: The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR. Read More

    Asthma predictive index in relation to respiratory mechanics by impulse oscillometry in recurrent wheezers.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):190-195. Epub 2018 Jan 10.
    Mersin University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Mersin, Turkey.
    Background: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing.

    Methods: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. Read More

    Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-β1 in Iranian children with atopic dermatitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):155-159. Epub 2018 Jan 5.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    Background: Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease.

    Objective: The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-β1 gene polymorphisms.

    Methods: The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. Read More

    Recommendations for the prevention and diagnosis of asthma in children: Evidence from international guidelines adapted for Mexico.
    Allergol Immunopathol (Madr) 2017 Dec 26. Epub 2017 Dec 26.
    Private Practice, San Luis Potosí, San Luis Potosí, Mexico.
    Background: With the availability of high-quality asthma guidelines worldwide, one possible approach of developing a valid guideline, without re-working the evidence, already analysed by major guidelines, is the ADAPTE approach, as was used for the development of National Guidelines on asthma.

    Methods: The guidelines development group (GDG) covered a broad range of experts from medical specialities, primary care physicians and methodologists. The core group of the GDG searched the literature for asthma guidelines 2005 onward, and analysed the 11 best guidelines with AGREE-II to select three mother guidelines. Read More

    Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):144-148. Epub 2017 Dec 24.
    Department of Ophthalmology, Yi Chang Hospital of Traditional Chinese Medicine, Yi Chang, China. Electronic address:
    Background: Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC. Read More

    iNKT cells are increased in children with severe therapy-resistant asthma.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):175-180. Epub 2017 Dec 24.
    Laboratory of Pediatric Respirology, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Infant Center, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil; Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil.
    Background: Invariant natural killer T (iNKT) cells play complex functions in the immune system, releasing both Th1 and Th2 cytokines. The role of iNKT cells in human asthma is still controversial and never described in severe therapy-resistant asthma in children. The objective of this work was to analyse iNKT frequency in peripheral blood of children with severe therapy-resistant asthma (STRA), compared to children with milder asthma and healthy controls. Read More

    Flagellated protozoa detected in Dermatophagoides by light microscopy.
    Allergol Immunopathol (Madr) 2017 Dec 23. Epub 2017 Dec 23.
    Protozoal Respiratory Pathology Research Unit, INCLÍNICA Foundation, Calvo Sotelo, 16, 33007 Oviedo, Spain. Electronic address:
    House dust mites (HDM) are arthropods of medical importance due to their relationship with allergic diseases. House dust provides a detrital habitat for these organisms, in which human skin scales are a primary food source. For digestion, wall gut cells elaborate potent proteases. Read More

    Scabies, crusted (Norwegian) scabies and the diagnosis of mite sensitisation.
    Allergol Immunopathol (Madr) 2017 Dec 23. Epub 2017 Dec 23.
    Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
    Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE class antibodies to Sarcoptes scabiei allergens which cross-react with Dermatophagoides major allergens Der p 1 and Der p 2, positive immediate-type skin tests to house dust mite extracts should be interpreted cautiously. Additionally, scabies should be included routinely in the differential diagnosis of itchy rashes in patients living in those areas. Read More

    Change in gut microbiota for eczema: Implications for novel therapeutic strategies.
    Allergol Immunopathol (Madr) 2017 Dec 23. Epub 2017 Dec 23.
    Faculty of Foreign Languages and Cultures, Kunming University of Science and Technology, Kunming, Yunnan, China.
    Eczema is one of the most common inflammatory diseases, often constituting a lifelong burden for afflicted individuals. The complex interaction of host genetic and multiple environmental factors contribute to its pathogenesis. A relationship between maladjustment of gut microbiota and eczema has been brought into the light of day in most previous studies. Read More

    Serum periostin is not related to asthma predictive index.
    Allergol Immunopathol (Madr) 2017 Dec 23. Epub 2017 Dec 23.
    Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
    Background: In contrast to adult asthmatic patients, studies on the role of serum periostin levels in schoolchildren with asthma are still conflictive, and very few studies have been performed in pre-schoolers. The aim of this study was to compare serum periostin levels in recurrent wheezer pre-schoolers according to their asthma predictive index (API) condition.

    Methods: We performed a case-control study enrolling pre-schoolers with recurrent wheezing episodes (>3 episodes confirmed by physician) presented at one paediatric clinic in Santiago, Chile. Read More

    Cross-over clinical trial for evaluating the safety of camel's milk intake in patients who are allergic to cow's milk protein.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):149-154. Epub 2017 Dec 6.
    Department of Gastroenterology and Nutrition, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.
    Background: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Read More

    Comparing the effects of fluticasone, anti-IgE and anti-TNF treatments in a chronic asthma model.
    Allergol Immunopathol (Madr) 2017 Nov 27. Epub 2017 Nov 27.
    Department of Pulmonology, Kahramanmaras Sutcu Imam University School of Medicine, Kahramanmaras, Turkey.
    Background: Corticosteroids are used in the treatment of asthma. The aim of this study was to determine the efficacy of anti-IgE and anti-TNF alpha as asthma treatments.

    Methods: A mouse model of chronic asthma was developed. Read More

    Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):136-143. Epub 2017 Nov 23.
    Pathology Experimental Laboratory, School of Medicine, Pontifical Catholic University of Paraná, Curitiba, Brazil.
    Asthma is a heterogeneous disease characterised by chronic airway inflammation. One of the most devastating consequences of this inflammatory process is the generation of reactive oxygen and nitrogen species responsible for oxidative stress. The aim of this study is to analyse the efficiency of treatment with human bone marrow-derived mesenchymal stromal cells (hMSC) in maintaining the oxidative balance in a murine model of allergic asthma by quantifying nitrotyrosine in lung tissues. Read More

    Tablet-based sublingual immunotherapy for respiratory allergy.
    Allergol Immunopathol (Madr) 2017 Dec 13;45 Suppl 1:30-35. Epub 2017 Nov 13.
    Sección de Alergologia, Hospital Dr Peset and Universidad de Valencia, Spain. Electronic address:
    Allergic respiratory disease represents a significant and expanding health problem worldwide. The gold standard of therapeutic intervention is still grucocorticosteroids, although they are not effective in all patients and may cause side effects. Allergen Immunotherapy has been administrated as subcutaneous injections for treatment of allergic rhinoconjunctivitis and asthma and has been practiced for the past century. Read More

    Quality requirements for allergen extracts and allergoids for allergen immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 9;45 Suppl 1:4-11. Epub 2017 Nov 9.
    Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, Langen, Germany. Electronic address:
    All allergen products for allergen immunotherapy currently marketed in the European Union are pharmaceutical preparations derived from allergen-containing source materials like pollens, mites and moulds. Especially this natural origin results in particular demands for the regulatory requirements governing allergen products. Furthermore, the development of regulatory requirements is complicated by the so far missing universal link between certain quality parameters, in particular biological potency, on the one hand and clinical efficacy on the other hand. Read More

    Non-protease native allergens partially purified from bodies of eight domestic mites using p-aminobenzamidine ligand.
    Allergol Immunopathol (Madr) 2017 Nov 8. Epub 2017 Nov 8.
    Medical Center Prague, Mezi Vodami 205/29, Prague 4-Modrany, CZ-14300, Czech Republic.
    Background: Optimised purification steps for concentrating trace target native antigens are needed. Combining the p-aminobenzamidine ligand with protease inactivation enables partial purification of mite non-protease allergens lacking proteases.

    Objective: We sought to analyse in detail proteins obtained using this method from eight species of synanthropic acaridid mites and tested IgE reactivity using pooled human sera. Read More

    Predictive biomarkers in allergen specific immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:12-14. Epub 2017 Nov 3.
    IMMA, Institute of Applied Molecular Medicine, Faculty of Medicine, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain; Basic Medical Sciences Department, Faculty of Medicine, Universidad San Pablo CEU, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain.

    Biologics in the treatment of severe asthma.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:45-49. Epub 2017 Nov 3.
    Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain; CIBER de Enfermedades Respiratorias, CIBERES, Spain.
    Severe asthma is defined as asthma which requires treatment with high dose inhaled corticosteroids and with a second controller drug to prevent it from becoming uncontrolled or which remains uncontrolled despite this therapy. Patients with uncontrolled severe asthma require additional treatment options as add-on therapy, including biologics. Biologic therapies in asthma are designed to block key immune regulators, such as IgE, or certain pro-inflammatory cytokines, e. Read More

    New insight into cancer immunotherapy.
    Allergol Immunopathol (Madr) 2017 Dec 3;45 Suppl 1:50-55. Epub 2017 Nov 3.
    IMMA, Institute of Applied Molecular Medicine, Faculty of Medicine, CEU San Pablo University, Campus Monteprincipe, Boadilla del Monte, 28668 Madrid, Spain.
    A key point for maintenance of the immune system homeostasis is the balance between the capacity to recognize and fight exogenous molecules and the capacity to avoid auto reactivity. The disruption of this balance induces the progression of several immune diseases such as autoimmune diseases, allergies, infections or cancer. A promising therapeutic approach to treat these diseases is immunotherapy. Read More

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