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    2792 results match your criteria Allergologia et Immunopathologia [Journal]

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    Sublingual immunotherapy of house dust mite respiratory allergy in China.
    Allergol Immunopathol (Madr) 2018 Jun 16. Epub 2018 Jun 16.
    Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
    Sublingual immunotherapy (SLIT) has been widely used for the treatment of allergic respiratory diseases, but many problems remain unsolved. Currently available data suggest that SLIT is very effective in children and adults with IgE-mediated respiratory diseases. Most allergists in China generally believe that SLIT is suitable for allergic rhinitis and asthma due to its safety and tolerability. Read More

    Clinical and immunological profile of children aged 5-9 years with persistent egg allergy before oral immunotherapy with egg. A multicenter, randomized controlled trial of the Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology (SEICAP).
    Allergol Immunopathol (Madr) 2018 May 24. Epub 2018 May 24.
    Idipaz, Institute for Health Research, La Paz University Hospital, Madrid, Spain.
    Background: In children with egg protein allergy (EA), the probability of overcoming the allergy decreases with age, and the possibility of suffering severe adverse reactions as a consequence of dietetic transgressions results in worsened quality of life. One treatment option in such cases is oral immunotherapy (OIT) with foods.

    Methods: We present a cohort of children with EA scheduled for OIT with pasteurized raw egg white, describing their clinical and allergic characteristics before the start of OIT. Read More

    Evaluation of serum IgE in peach-allergic patients with systemic reaction by using recombinant Pru p 7 (gibberellin-regulated protein).
    Allergol Immunopathol (Madr) 2018 May 18. Epub 2018 May 18.
    Department of Pediatrics, Fujita Health University Second Educational Hospital, Aichi, Japan.
    Background: Lipid transfer protein (LTP) is a major fruit allergen. It has, however, recently been revealed that the systemic reaction in peach-allergic patients is related not only to LTP (Pru p 3) but also to gibberellin-regulated protein (Pru p 7). We investigated recombinant Pru p 7 (rPru p 7) for its potential use in worldwide standardization for the diagnosis of peach allergy. Read More

    Exome sequencing revealed C1Q homozygous mutation in Pediatric Systemic Lupus Erythematosus.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    Introduction And Objectives: Pediatric Systemic Lupus Erythematosus (pSLE) is an autoimmune disorder of children. Early disease onset raises the probability of genetic etiology and it is more severe than adult SLE.

    Patients And Methods: Herein an eight-year-old girl with pSLE from consanguineous parents is reported. Read More

    Resources to handle childhood asthma in Spain: The role of plans and guides and the participation of nurses.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):361-369. Epub 2018 May 5.
    CS La Candelaria, Sevilla, Spain.
    Background: Describe the assistance provided to asthmatic patients by Primary Care Paediatricians (PCP) in Spain and the material and human resources available for diagnosis and follow-up.

    Methods: A cross-sectional descriptive study using an on-line survey, sent to PCP regarding the availability of diagnostic resources, carrying out programmed and educational activities, collaboration of nursing staff and their relationship with existing institutional plans to care for children with asthma. A latent class model (LCM) was used to describe the differences among paediatricians based on the variables studied. Read More

    The role of regulatory T cells in the acquisition of tolerance to food allergens in children.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    Laboratory of Immune-regulation, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid Spain. Electronic address:
    Food allergy is a pathological immune reaction that identifies certain harmless food proteins, usually tolerated by the majority of the people, as a threat. The prevalence of these food allergies is increasing worldwide and currently affects 8% of children. Exacerbated reactions to milk, egg and peanut are the most frequent in the pediatric population. Read More

    Prolonged breastfeeding and delayed introduction of whole cow's milk into the diet are factors associated with egg sensitization: A matched case-control study.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    División de Pediatría, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca", Salvador de Quevedo y Zubieta No. 750, Colonia La Perla, C. P. 44340, Guadalajara, Jalisco, Mexico.
    Background: Both breastfeeding and the moment at which introduction to solid food occurs have been associated with food allergy.

    Objective: To evaluate whether prolonged breastfeeding and the delayed introduction of whole cow's milk into an infant's diet are factors that can be associated with egg sensitization.

    Methods: This was a hospital-based case-control study, matched by age and sex: each study group comprised 97 atopic children. Read More

    B-cell subsets imbalance and reduced expression of CD40 in ataxia-telangiectasia patients.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    Department of Pediatrics, Federal University of Sao Paulo Medical School, 598, Botucatu Street, Vila Clementino, São Paulo, SP 04023-062, Brazil. Electronic address:
    Background: Ataxia-telangiectasia (AT) is a well-known primary immunodeficiency with recurrent sinopulmonary infections and variable abnormalities in both the humoral and cellular immune system. Dysfunctions in immunoglobulin production, reduced number of B cells, and B-cell receptor excision circles copies have been reported. We aimed to understand the immunological mechanisms involving the humoral compartment in AT patients by analysing peripheral blood B cells subsets, B-T lymphocyte cooperation through the expression of CD40 and CD40 ligand (CD40L), and cytokines involved in class-switch recombination production. Read More

    Ameliorating effects of Nigella sativa oil on aggravation of inflammation, oxidative stress and cytotoxicity induced by smokeless tobacco extract in an allergic asthma model in Wistar rats.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    Laboratory of Biochemistry and Environmental Toxicology, Department of Biochemistry, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria. Electronic address:
    Background: The comparison of smokeless tobacco (ST) exposure versus Ovalbumin (Ova) sensitized rats or asthmatic patients has hardly been studied in the literature. Thus, the present study aims to investigate the aggravation of inflammation, exacerbation of asthma, oxidative stress and cytotoxicity induced by ST.

    Methods: ST was given at the dose of 40mg/kg in an allergic asthma model in Wistar rats. Read More

    Fungal Allergy: Pattern of sensitization over the past 11 years.
    Allergol Immunopathol (Madr) 2018 May 5. Epub 2018 May 5.
    Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.
    Introduction And Objectives: Although the prevalence of sensitization to fungi is not precisely known, it can reach 50% in inner cities and has been identified as a risk factor in the development of asthma. Whereas the prevalence of allergic diseases is increasing, it is unclear whether the same occurs with sensitization to fungi.

    Patients And Methods: A retrospective study was performed at the "Hospital Infantil de México Federico Gómez". Read More

    Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):354-360. Epub 2018 May 5.
    Department of Food Science and Technology, HungKuang University, Taichung, Taiwan. Electronic address:
    Background: Probiotics could be beneficial to health and some of them have shown to modulate immune responses.

    Aim: The aim of this study is to investigate if the probiotic strains including Lactobacillus and Pediococcus strains are able to alleviate allergic reactions in an ovalbumin-induced airway allergy model.

    Methods: Lactobacillus multi-species preparation (LMP) was gavaged to BALB/c for total six weeks and BALB/c was challenged with ovalbumin in the last two weeks. Read More

    Hospitalizations for asthma exacerbation in Chilean children: A multicenter observational study.
    Allergol Immunopathol (Madr) 2018 Apr 29. Epub 2018 Apr 29.
    San Juan De Dios Hospital, Huérfanos 3255, Santiago 8350488, Región Metropolitana, Chile.
    Background: Asthma hospitalization rates in Chilean children have increased in the last 14 years, but little is known about the factors associated with this.

    Objective: Describe clinical characteristics of children hospitalized for asthma exacerbation.

    Methods: Observational prospective cohort study in 14 hospitals. Read More

    Features and roles of T helper 9 cells and interleukin 9 in immunological diseases.
    Allergol Immunopathol (Madr) 2018 Apr 24. Epub 2018 Apr 24.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:
    T helper 9 (T9) cells are considered as newly classified helper T cells that have an important role in the regulation of immune responses. Since these cells preferentially produce IL-9, these cells are termed T9 cells. Recently, the role of T9 and its signature cytokine (IL-9) has been investigated in a wide range of diseases, including autoimmunity, allergy, infections, cancer and immunodeficiency. Read More

    Relation between serum CC16 levels and asthma predictive index in pre-schoolers with recurrent wheezing.
    Allergol Immunopathol (Madr) 2018 Apr 20. Epub 2018 Apr 20.
    Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
    Background: Low levels of serum CC16 were reported in asthmatic adults, but the studies on children were scarce and conflicting. The aim of this study was to compare serum CC16 levels in pre-school children with recurrent wheezing assessed using an asthma predictive index (API).

    Methods: We performed a case-control study based on API, with all enrolled pre-school children who had recurrent wheezing episodes (>3 episodes/last year confirmed by a physician) and had presented at one paediatric clinic in Santiago, Chile. Read More

    An international comparison of risk factors between two regions with distinct differences in asthma prevalence.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):341-353. Epub 2018 Mar 24.
    Canadian Center for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Canada; Department of Medicine, University of Saskatchewan, Saskatoon, Canada. Electronic address:
    Background And Purpose: Investigation of the geographic variation in asthma prevalence can improve our understanding of asthma etiology and management. The purpose of our investigation was to compare the prevalence of asthma and wheeze among adolescents living in two distinct international regions and to investigate reasons for observed differences.

    Methods: A cross-sectional survey of 13-14 year olds was completed in Saskatoon, Canada (n=1200) and Skopje, Republic of Macedonia (n=3026), as part of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3 study. Read More

    Is vitamin D level associated with the natural course of atopic dermatitis?
    Allergol Immunopathol (Madr) 2018 Mar 17. Epub 2018 Mar 17.
    Health Sciences University, Zeynep Kamil Woman and Children Health Practice and Research Center, Department of Pediatrics, Istanbul, Turkey. Electronic address:
    Introduction And Objectives: Atopic dermatitis (AD) is a chronic inflammatory disease of the skin. Apart from its well-known role on calcium metabolism, vitamin D is reported to affect skin functions. The study aims were to: compare the vitamin D levels of children with AD and healthy children; investigate the relationship between the severity of AD and vitamin D levels; and investigate the effect of vitamin D on the natural course of AD. Read More

    Adherence to pharmacotherapy improves school performance in children with rhinitis and asthma.
    Allergol Immunopathol (Madr) 2018 Mar 17. Epub 2018 Mar 17.
    Group of Clinical and Experimental Allergy (GACE), IPS Universitaria, University of Antioquia, Medellín, Colombia.
    Background: Adherence to pharmacotherapy reduces symptoms of asthma and rhinitis, however, little is known of its impact on school performance.

    Objective: To evaluate the impact of pharmacotherapy in absenteeism and school performance in a child population.

    Methods: A cross-sectional study, carried out in eight schools. Read More

    Assessment of IL-31 levels and disease severity in children with atopic dermatitis.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):322-325. Epub 2018 Mar 17.
    Department of Pediatrics, İstanbul Bilim University, Istanbul, Turkey.
    Introduction And Objectives: Atopic dermatitis is a chronic, relapsing, highly pruritic, inflammatory skin disease characterized by typical localization with increasing prevalence of 10-20% in children. Pruritus is one of the major diagnostic criteria of atopic dermatitis and also the main complaint altering quality-of-life of affected patients, inducing and aggravating inflammation. Although pruritus is the absolute symptom of AD, the etiology has not been fully explained yet and current antihistamine therapies are ineffective. Read More

    Parental confusion may result when primary health care professionals show heterogeneity in their knowledge, attitudes, and perceptions regarding infant nutrition, food allergy, and atopic dermatitis.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):326-333. Epub 2018 Feb 26.
    PEDEGO Research Unit and MRC Oulu, University of Oulu and Oulu University Hospital, P.O. Box 5000, FIN 90014 Oulu, Finland; Biomedicine Research Unit, Medical Microbiology and Immunology, University of Oulu, P.O. Box 5000, FIN 90014 Oulu, Finland.
    Introduction And Objectives: Whether the guidelines on infant nutrition, food allergy and atopic dermatitis confer real health benefits in practice at the population level has not been deeply studied. We aimed here to characterize the knowledge, attitudes, and perceptions regarding these issues among primary health care professionals. In addition, we surveyed available parent-reported information sources and the incidence of food-related symptoms, dietary restrictions, food allergy, and atopic dermatitis among one-year-old children in the general population. Read More

    Iberian consensus on cow's milk allergy: The CIBAL Study.
    Allergol Immunopathol (Madr) 2018 Feb 21. Epub 2018 Feb 21.
    Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisboa, Portugal.
    Background: The present study explores the professional opinion of a wide range of experts from the Iberian Peninsula (Spain and Portugal) and their degree of consensus about CMPA's prevention, diagnosis, treatment and progression.

    Material And Methods: A 57-item survey divided in four blocks: Prevention (14 items), Diagnosis (10 items), Treatment (19 items) and Progression (14 items) was completed by 160 panellists, experts in CPMA management (116 Spain, 44 Portugal). Each one answered the questionnaire, formulated in Portuguese and Spanish, by individually accessing an online platform in two consecutive rounds. Read More

    Is food protein induced enterocolitis syndrome only a non IgE-mediated food allergy?
    Allergol Immunopathol (Madr) 2018 Feb 19. Epub 2018 Feb 19.
    Allergy Unit, Department of Pediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    Food protein induced enterocolitis syndrome (FPIES) is classified as non-IgE-mediated or cell-mediated food allergy, although there is an atypical phenotype so defined for the presence of specific IgEs. All diagnostic criteria for FPIES include the absence of skin or respiratory symptoms of IgE-mediated type. We present four cases that suggest that specific IgEs may have a pathogenic role, resulting in the existence of different FPIES phenotypes. Read More

    Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Psicología Clínica, Eulogio Parra No. 2330-301, Col. Las Américas, C.P. 44650, Guadalajara, Jalisco, Mexico.
    Introduction: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent.

    Objective: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children.

    Method: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. Read More

    Increase of natural killer cells in children with liver transplantation-acquired food allergy.
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Allergy Unit, Department of Paediatrics, Anna Meyer Children's University Hospital, Florence, Italy.
    Background: Transplantation-acquired food allergies (TAFA) are frequently reported and considered to be caused by immunosuppressive therapy. The aim of this study was to investigate the allergic and immunologic responses in children who had liver or kidney transplantations.

    Methods: Twelve children receiving liver transplantations and 10 children receiving kidney transplantations were investigated. Read More

    Evaluation of an intervention to improve the management of allergens in school food services in the city of Barcelona.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):334-340. Epub 2018 Feb 15.
    Agència de Salut Pública de Barcelona (ASPB, Public Health Agency of Barcelona), Pl Lesseps 1, 08023 Barcelona, Spain. Electronic address:
    Background: An intervention to promote the development of an allergen control plan (ACP) and preventive measures for the management of allergens in school food services was implemented in all schools of Barcelona city over a three-year period (2013-2015) by the public health services. The present study aimed to assess changes regarding the management of food allergens in school food services in Barcelona after an intervention conducted by the public health services of the city.

    Methods: School meal operators of a random sample of 117 schools were assessed before and after the intervention using a structured questionnaire. Read More

    Diagnostic criteria for acute food protein-induced enterocolitis syndrome. Is the work in progress?
    Allergol Immunopathol (Madr) 2018 Feb 15. Epub 2018 Feb 15.
    Allergy Unit, Department of Paediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergic disorder. Some diagnostic criteria have been published for acute FPIES. Of course, they are not all the same, so the clinician must choose which ones to adopt for his/her clinical practice. Read More

    Effect of inhaled medication on dental caries index in asthmatic children.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):196-200
    Dentist, Private Practitioner, Shiraz, Iran. Electronic address:
    Introduction: Asthma is a chronic inflammatory disease of airways with a high prevalence among children in pre-school ages. Considering controversial results in different studies about the effect of this disease on the indices of dental caries, the aim of this study was to compare dmft (decay, missing, filling teeth) situation in asthmatic and non-asthmatic 6-12-year-old children.

    Methods: This was a case-control study on 46 asthmatic and 47 non-asthmatic children aged 6-12 years. Read More

    The roles of toll like receptor 3, 7 and 8 in allergic rhinitis pathogenesis.
    Allergol Immunopathol (Madr) 2018 Feb 2. Epub 2018 Feb 2.
    Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
    Allergic rhinitis, as an allergic and nasal hypersensitivity disease, is associated with the inflammation of nasal mucosa. It appears that innate immune receptors are the important risk factors in the pathogenesis of the inflammatory disease. Toll-like receptors (TLRs) are the most important receptors of innate immunity; their crucial roles in the recognition of allergens and subsequently pathogenesis of allergic diseases have been evaluated recently. Read More

    Pine nut allergy in Korean children: Clinical characteristics and diagnostic values of specific IgE against pine nuts.
    Allergol Immunopathol (Madr) 2018 May - Jun;46(3):247-252. Epub 2018 Feb 12.
    Department of Pediatrics, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:
    Background: Hypersensitivity reactions to pine nuts in children have been occasionally encountered recently, although reports on pine nut allergy cases are rare worldwide. The study aimed to feature clinical and laboratory findings pertaining to pine nut allergy in Korean children.

    Methods: Forty-two subjects were enrolled through a retrospective review of medical records, from September 2010 to December 2015, at the Department of Pediatrics in Ajou University Hospital. Read More

    Haploidentical stem cell transplantation in a boy with chronic granulomatous disease.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):385-388. Epub 2018 Jan 17.
    Pediatric Hematology & Oncology Department, Hospital Clínico Universitario de Santiago, Spain.
    Chronic granulomatous disease is a primary immunodeficiency caused by mutations in any one of the five components of the NADPH oxidase in phagocytic leucocytes. This causes impaired microbial killing, which leads to severe life-threatening bacterial and fungal infections. Currently, allogenic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for chronic granulomatous disease, although gene therapy may provide a new therapeutic option for the treatment of patients with CGD. Read More

    Fluticasone in mild to moderate atopic dermatitis relapse: A randomized controlled trial.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):378-384. Epub 2018 Jan 17.
    CS Auxiliar El Vedat de Torrent, Valencia, Spain.
    Background: The long-term efficacy of corticosteroids to prevent atopic dermatitis (AD) relapses has partially been addressed in children. This study compared an intermittent dosing regimen of fluticasone propionate (FP) cream 0.05% with its vehicle base in reducing the risk of relapse in children with stabilized AD. Read More

    Immunomodulation of allergic response in children and adolescents: What we can learn from lymphatic filarial infection.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):167-174. Epub 2018 Feb 1.
    Centro de Pesquisas em Alergia e Imunologia, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil; Postgraduate Program in Health Sciences, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
    Background: Although it is well known that allergic diseases involve a strong Th2 immune response, with production of high levels of specific IgE allergen, knowledge on the association between filarial infection and allergies, among paediatric patients is scarce.

    Objective: To evaluate the allergic response patterns in cases of filarial infection by comparing peripheral eosinophils, total IgE levels, immediate hypersensitivity and cytokine levels in children and adolescents in Brazil.

    Methods: This was an exploratory study with three groups: (I) with filarial infection and without allergic diseases; (II) without filarial infection and with allergic diseases; and (III) without filarial infection and without allergic diseases. Read More

    Development and characterization of an allergoid of cat dander for immunotherapy.
    Allergol Immunopathol (Madr) 2018 Jan 13. Epub 2018 Jan 13.
    Probelte Pharma S.L.U., Spain.
    Background: Allergy to cats is a frequent cause of sensitization to indoor allergens and currently there are few alternatives to specific immunotherapy with cat native extracts. The objective is to develop and characterize a new allergoid to increase the tools available for use in clinical practice.

    Methods: The allergoid cat dander extract (ACD) was developed from a native cat dander extract (NCD) by modification with glutaraldehyde, and the optimal process control was determined by SDS-PAGE, DOT BLOT and determination of free amine groups. Read More

    The role of regulatory RNAs (miRNAs) in asthma.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):201-205. Epub 2018 Jan 17.
    Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia.
    Introduction: Recently, a great deal of attention has been paid to the investigation of regulatory functions of microRNA. Currently, many different mechanisms involved in the pathogenesis of asthma are known, but the whole picture of pathogenesis has not yet been studied.

    Conclusions: MicroRNAs play an important role in the regulation of many cellular processes. Read More

    Quality of life and clinical characterization of patients with vernal keratoconjunctivitis in a pediatric population in Colombia.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):370-377. Epub 2018 Jan 12.
    GACE Group Research Associate, Universidad de Antioquia, Colombia; Clinical Allergist IPS Universitaria - Universidad de Antioquia, Colombia. Electronic address:
    Vernal keratoconjunctivitis is one of the most serious ocular allergies that have the potential to induce large ocular morbidity and significant visual changes affecting the quality of life of these individuals.

    Methodology: This study was conducted in two phases. The first phase consisted of the clinical characterization of 32 patients from the Clinical Allergology center of the I. Read More

    Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):389-393. Epub 2018 Jan 12.
    Department of Paediatrics, Imperial College London, London, UK.
    Background: Obstructive respiratory disorders, such as allergic rhinitis and asthma may impair sleep quality. The aim of this study is to validate the Children's Sleep Habits Questionnaire (CSHQ) for Greek children from 6 to 14 years of age. No validated tool has been developed so far to assess sleep disturbances in Greek school-aged children. Read More

    Loss of tolerance for fishes previously tolerated in children with fish food protein induced enterocolitis syndrome.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):394-396. Epub 2018 Jan 17.
    Department of Pediatrics, Agostino Gemelli Hospital, Sacred Heart Catholic University, Rome, Italy.
    We describe two case reports presenting some novel information on fish FPIES. Fish FPIES to one fish does not always start at the same time to other fish. Additionally, development of tolerance to the index fish do not necessarily imply tolerance to other reactive fish. Read More

    Knowledge on asthma, food allergies, and anaphylaxis: Assessment of elementary school teachers, parents/caregivers of asthmatic children, and university students in Uruguaiana, in the state of Rio Grande do Sul, Brazil.
    Allergol Immunopathol (Madr) 2018 Jan 12. Epub 2018 Jan 12.
    Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of Sâo Paulo, SP, Brazil. Electronic address:
    Introduction: Allergic diseases have become an increasingly common reality in the last years, extending beyond the family context.

    Objective: Assessing the level of knowledge on asthma, food allergies and anaphylaxis of asthmatic children's parents/caregivers (PC), elementary school teachers (EST) and university students (US) in Uruguaiana, RS, Brazil.

    Method: 577 individuals (PC - N=111; EST - N=177; US - N=299) took part in the study, answering the Newcastle Asthma Knowledge Questionnaire (validated for Portuguese) and another questionnaire on Food Allergy (FA) and anaphylaxis. Read More

    Is eosinophilic esophagitis an equivalent of pollen allergic asthma? Analysis of biopsies and therapy guided by component resolved diagnosis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):181-189. Epub 2018 Jan 12.
    Histology Department, Valladolid University, Spain.
    Background: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is not a clear etiologic treatment. Biopsies analysis using plant histology methods may show callose and pollen tubes in the esophageal mucosa. Read More

    Small-airway dysfunction precedes the development of asthma in children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Jul - Aug;46(4):313-321. Epub 2018 Jan 12.
    Pediatric Pulmonology and Allergy Unit, Department of Pediatrics, University of Patras Medical School, Patras, Greece.
    Background: Epidemiological evidence suggests the existence of a direct link between allergic rhinitis (AR) and asthma. Several studies also support the presence of small-airway dysfunction (SAD) in non-asthmatic children with AR. However, it remains unknown whether SAD can predict the progression of AR to asthma. Read More

    Mycoplasma pneumoniae and toll-like receptors: A mutual avenue.
    Allergol Immunopathol (Madr) 2018 Jan 10. Epub 2018 Jan 10.
    Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran. Electronic address:
    Mycoplasma pneumoniae is an intracellular bacterium leading to several complications in humans. M. pneumoniae is cleared in some cases and induces complications in others. Read More

    Efficacy and safety of sublingual immunotherapy with Dermatophagoides farinae drops in pre-school and school-age children with allergic rhinitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):107-111. Epub 2018 Jan 11.
    Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute, Capital Medical University, Beijing 100020, China. Electronic address:
    Background: The safety and efficacy of sublingual immunotherapy (SLIT) have been confirmed by many studies. However, in China, the research on efficacy and safety in young and older children with allergic rhinitis (AR) is still rare.

    Objective: The aim of this retrospective study is to evaluate the efficacy and safety of SLIT with Dermatophagoides farinae drops in pre-school and school-age children with AR. Read More

    Asthma predictive index in relation to respiratory mechanics by impulse oscillometry in recurrent wheezers.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):190-195. Epub 2018 Jan 10.
    Mersin University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Mersin, Turkey.
    Background: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing.

    Methods: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. Read More

    Single nucleotide polymorphisms of the genes encoding IL-10 and TGF-β1 in Iranian children with atopic dermatitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):155-159. Epub 2018 Jan 5.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    Background: Atopic dermatitis is an inflammatory skin disease in which both genetic and environmental factors interact to determine the susceptibility and severity of the disease.

    Objective: The aim of this study was to determine the association between atopic dermatitis and IL-10 and TGF-β1 gene polymorphisms.

    Methods: The allele and genotype frequencies of genes encoding for IL-10 and TGF-β1 were investigated in 89 patients with atopic dermatitis in comparison with 138 in the control group using the PCR-SSP method. Read More

    Recommendations for the prevention and diagnosis of asthma in children: Evidence from international guidelines adapted for Mexico.
    Allergol Immunopathol (Madr) 2018 May - Jun;46(3):291-303. Epub 2017 Dec 26.
    Private Practice, San Luis Potosí, San Luis Potosí, Mexico.
    Background: With the availability of high-quality asthma guidelines worldwide, one possible approach of developing a valid guideline, without re-working the evidence, already analysed by major guidelines, is the ADAPTE approach, as was used for the development of National Guidelines on asthma.

    Methods: The guidelines development group (GDG) covered a broad range of experts from medical specialities, primary care physicians and methodologists. The core group of the GDG searched the literature for asthma guidelines 2005 onward, and analysed the 11 best guidelines with AGREE-II to select three mother guidelines. Read More

    Tear osteopontin level and its relationship with local Th1/Th2/Th17/Treg cytokines in children with allergic conjunctivitis.
    Allergol Immunopathol (Madr) 2018 Mar - Apr;46(2):144-148. Epub 2017 Dec 24.
    Department of Ophthalmology, Yi Chang Hospital of Traditional Chinese Medicine, Yi Chang, China. Electronic address:
    Background: Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC. Read More

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