2,864 results match your criteria Allergologia et Immunopathologia [Journal]


MEDITERRANEAN DIET AND ASTHMA: TIME FOR CLINICAL TRIALS IN CHILDREN.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):207-208

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; IMIB Bio-health Research Institute; and ARADyAL allergy network, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.04.001DOI Listing
April 2019
1 Read

Youth tobacco use in Latin America: What is the real extent of the problem?

Allergol Immunopathol (Madr) 2019 Mar 30. Epub 2019 Mar 30.

Medical student - Federal University of Pampa, Uruguayana, Rio Grande do Sul, Brazil.

Introduction: Cigarette consumption among teenagers is one of the most critical health-related risk behaviors.

Method: Prospective study carried out in seven sites of five Latin American countries (Argentina [Cordoba, N=958, Corrientes, N=1013], Brazil [Curitiba, N=650; Uruguaiana, N=997], Cuba [Havana, N=1004], Mexico [Veracruz, N=991] and Paraguay [Ciudad del Este, N=868]) with public-school adolescents (aged 12-19 years). Respondents were asked to answer the California Student Tobacco Survey. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.010DOI Listing
March 2019
2 Reads

The unpredictability of seasonal variations in serum vitamin D levels in children with asthma and/or rhinitis.

Allergol Immunopathol (Madr) 2019 Mar 30. Epub 2019 Mar 30.

Public Health Institute, Catholic University of Sacred Heart, Rome, Italy.

Background: Some studies have showed that seasonality is an important determinant of vitamin D (vitD) status.

Objective: We evaluated whether there are differences in individual trends of serum vitD level over one year in asthmatic and rhinitic children.

Materials And Methods: Ninety-two asthmatic and rhinitic paediatric patients were followed up for one year and their serum vitD level was detected at three-month intervals, once in each season. Read More

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http://dx.doi.org/10.1016/j.aller.2019.01.002DOI Listing
March 2019
2 Reads

Short and extended provocation tests have similar negative predictive value in non-immediate hypersensitivity to beta-lactams in children.

Allergol Immunopathol (Madr) 2019 Mar 22. Epub 2019 Mar 22.

Serviço de Imunoalergologia, Centro Hospitalar do Porto, Porto, Portugal. Electronic address:

Introduction And Objectives: Drug provocation tests (DPTs) are the gold-standard method to diagnose non-immediate hypersensitivity reactions (NIHSR) to beta-lactam antibiotics (BL) in children. Our aim was to compare the negative predictive value (NPV) of one-day (short) DPT versus 3-7 days (extended) DPT for the diagnosis of NIHSR to BL in paediatric age. A secondary aim was to compare confidence on drug re-exposure after short and extended negative DPTs. Read More

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http://dx.doi.org/10.1016/j.aller.2019.01.004DOI Listing
March 2019
2 Reads

Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children.

Allergol Immunopathol (Madr) 2019 Mar 20. Epub 2019 Mar 20.

Introduction And Objectives: Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack.

Patients And Methods: Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.010DOI Listing
March 2019
3 Reads

IFN-γ stimulation of dental follicle mesenchymal stem cells modulates immune response of CD4 T lymphocytes in Der p1 asthmatic patients in vitro.

Allergol Immunopathol (Madr) 2019 Feb 27. Epub 2019 Feb 27.

Marmara University Faculty of Medicine Department of Pediatric Allergy and Immunology, Istanbul, Turkey.

Background: House dust mite (Dermataphagoides pteronyssinus) is a widespread risk factor in the development of asthma. CD4 T lymphocytes have an important role in the pathogenesis of allergic asthma by polarizing to Th2 cells.

Objective: We aimed to evaluate the immunoregulatory effects of dental follicle mesenchymal stem cells with and without IFN-γ stimulation on peripheral blood mononuclear cells of house dust mite sensitive asthmatic patients, and compared those with Dexamethasone as a systemic steroid. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010546193000
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http://dx.doi.org/10.1016/j.aller.2018.12.005DOI Listing
February 2019
2 Reads

Residential crowding and asthma in preschool children, a cross-sectional study.

Allergol Immunopathol (Madr) 2019 Feb 20. Epub 2019 Feb 20.

Department of Occupational and Environmental Health/Epidemiology, Bavarian Health and Food Safety Authority (LGL), Pfarrstr. 3, 80538 Munich, Germany; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Clinic of the University of Munich, Ziemssenstr. 1, 80336 Munich, Germany.

Background: Asthma is the most common chronic disease in children, and associations with crowding have been reported. The aim of this study was to explore possible associations of crowding with asthma in children.

Methods: Seven cross-sectional surveys with preschool children were conducted within the framework of the health monitoring units in Bavaria, Germany, from 2004 to 2014. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.008DOI Listing
February 2019
1 Read

Asthma, exercise and metabolic dysregulation in paediatrics.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):289-294. Epub 2018 Jun 28.

Department of Clinical and Experimental Medicine, Section of Paediatric, University of Pisa, Pisa, Italy. Electronic address:

Asthma is the most frequent chronic disease in childhood. Chest tightness, cough, wheezing and dyspnoea during or after exercise may be unique manifestations of asthma in up to 90% of subjects. Physical activity may be reduced by uncontrolled asthma symptoms and parental beliefs, impairing physical fitness of asthmatic children. Read More

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http://dx.doi.org/10.1016/j.aller.2018.03.010DOI Listing

Identification of polcalcin as a novel allergen of Amaranthus retroflexus pollen.

Allergol Immunopathol (Madr) 2019 Feb 12. Epub 2019 Feb 12.

Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Amaranthus retroflexus (Redroot Pigweed) is one of the main sources of allergenic pollens in temperate areas. Polcalcin is a well-known panallergen involved in cross-reactivity between different plants. The aim of this study was the molecular cloning and expression of polcalcin, as well as evaluating its IgE-reactivity with A. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.006DOI Listing
February 2019
2 Reads

SO, AT WHAT AGE CAN ASTHMA BE DIAGNOSED?

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):105-106

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; and IMIB Bio-health Research Institute, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2019.01.001DOI Listing
January 2019
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Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma.

Allergol Immunopathol (Madr) 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Microbiology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul 34320, Turkey. Electronic address:

Introduction And Objectives: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.009DOI Listing
February 2019
1 Read

Predicting outgrowth of IgE-mediated cow's milk allergy: Diagnostic tests in children under two years of age.

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Division of Pediatric Allergy and Immunology, Kocaeli University Faculty of Medicine, Turkey. Electronic address:

Background: Limited studies conducted on children <2 years old and/or involving a skin prick test (SPT) for fresh milk (FM) have examined the predictive value of allergometric tests for outgrowth of cow's milk allergy (CMA). We investigated the optimal decision points for outgrowth (ODP) with SPT for commercial cow's milk extract (CE) and FM and specific immunoglobulin E (sIgE) levels for milk proteins to predict outgrowing allergy in children <2 years old.

Methods: SPTs for CE and FM, tests for sIgEs (cow's milk, casein, α-lactoalbumin, β-lactoglobulin) and oral food challenges (OFC) were performed in children referred for evaluation of suspected CMA, and 15 months after diagnosis. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.007DOI Listing
February 2019
2 Reads

Prevalence of asthma, allergic rhinitis and eczema in 6-7-year-old schoolchildren from Luanda, Angola.

Allergol Immunopathol (Madr) 2019 Feb 8. Epub 2019 Feb 8.

Department of Allergy & Clinical Immunology, Cova da Beira University Hospital, Quinta do Alvito, 6200-251 Covilhã, Portugal; CICS - Health Sciences Research Centre, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal. Electronic address:

Background: Epidemiological data have shown that the prevalence of asthma, rhinoconjunctivitis and eczema in children is still increasing, namely in Africa. However, there are no epidemiological studies on asthma or allergic diseases in Angolan children.

Objective: To study the prevalence of asthma and other allergic diseases in Angolan children. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.002DOI Listing
February 2019
10 Reads

Effect of ginger extract on expression of GATA3, T-bet and ROR-γt in peripheral blood mononuclear cells of patients with Allergic Asthma.

Allergol Immunopathol (Madr) 2019 Feb 10. Epub 2019 Feb 10.

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Introduction And Objectives: Allergic asthma is a chronic inflammatory disorder of the airways. Th1, Th2 and Th17 cells are the main cells involved in the pathophysiology of asthma. The function of these cells is affected by T-bet, GATA3 and RORγt transcription factors (respectively). Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.003DOI Listing
February 2019
1 Read

The clinical relevance of molecular diagnosis in children allergic to grass pollen and treated with allergen immunotherapy.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):309-310. Epub 2019 Feb 6.

Allergologia, Casa di Cura Villa Montallegro, Genoa, Italy.

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http://dx.doi.org/10.1016/j.aller.2018.12.004DOI Listing
February 2019
2 Reads

Headache deteriorates the quality of life in children with chronic spontaneous urticaria.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):254-259. Epub 2019 Jan 25.

Akdeniz University, Department of Pediatric Allergy and Immunolgy, Antalya, Turkey.

Background: Quality of life, which is impaired in patients with chronic spontaneous urticaria (CSU), is influenced by comorbid mental disorders. Headaches could be another comorbid mental disorder that affects quality of life in children with CSU.

Objectives: To investigate the effect of headaches on urticaria symptoms, disease activity and quality of life in children with CSU. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.002DOI Listing
January 2019
3 Reads

Epidemiologic studies about food allergy and food sensitization in tropical countries. Results and limitations.

Allergol Immunopathol (Madr) 2019 Jan 19. Epub 2019 Jan 19.

Group of Clinical and Experimental Allergy, IPS Universitaria, Universidad de Antioquia, Medellín, Colombia; University corporation Rafael Nuñez, Immunology Department, Cartagena, Colombia.

The variety of foods and methods of preparation are part of the cultural identity of each population, and thus the main foods that cause symptoms vary among different regions. Due to their increasing frequency, Adverse Reactions to Food (AFR) have been the subject of extensive study, especially in North America and Europe but few studies have been conducted in other areas, especially in populations located in the tropics and subtropics. In this article, we review available information on the epidemiology of food sensitization and food allergies in tropical regions and explore the different epidemiological data considering the major food involved, the underlying immune mechanism and clinical symptoms partners. Read More

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http://dx.doi.org/10.1016/j.aller.2018.11.001DOI Listing
January 2019
3 Reads

Treatment, outcomes and costs of asthma exacerbations in Chilean children: a prospective multicenter observational study.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):282-288. Epub 2018 Dec 27.

San Juan De Dios Hospital, Huérfanos 3255, Zip Code 8350488 Santiago, Región Metropolitana, Chile.

Objective: To describe potential regional variations in therapies for severe asthma exacerbations in Chilean children and estimate the associated health expenditures.

Methods: Observational prospective cohort study in 14 hospitals over a one-year period. Children five years of age or older were eligible for inclusion. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.003DOI Listing
December 2018
3 Reads

EARLY PROGRAMMING OF ASTHMA AND ALLERGY: IT IS TIME TO SERIOUSLY THINK OF PRIMARY PREVENTION.

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1)

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia; and IMIB Bio-health Research Institute. Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03010546183015
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http://dx.doi.org/10.1016/j.aller.2018.12.001DOI Listing
November 2018
3 Reads

Molecular study of hypersensitivity to spores in adults and children from Castile & Leon.

Allergol Immunopathol (Madr) 2018 Dec 18. Epub 2018 Dec 18.

Biodiversity and Environmental Management, University of León, León, Spain; Institute of Atmospheric Sciences and Climate, National Research Council, Bologna, Italy.

Introduction And Objectives: Biological aerosols play a vital role in the interactions between the atmosphere, biosphere, climate and public health and fungal spores are a component with allergic importance. We constructed a database in Castile & Leon (Spain) and carry out molecular-level component-resolved diagnosis to complete the air quality study carried out since 2006 by our aerobiological network (RACYL) to aid clinical diagnosis and treatment.

Methods: We reviewed a database of 19,774 patients (adults and children) with allergic respiratory disease treated in our unit during the last 12 years. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.002DOI Listing
December 2018
1 Read

Yogurt is tolerated by the majority of children with IgE-mediated cow's milk allergy.

Allergol Immunopathol (Madr) 2018 Dec 17. Epub 2018 Dec 17.

Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Policlinico Gemelli Universitary Foundation IRCCS, Catholic University of Sacre Hearth, Rome, Italy. Electronic address:

Background: Children with IgE-mediated cow's milk allergy (IgE-CMA) with gastrointestinal symptoms tolerate yogurt at 100%. Yogurt tolerance in children with IgE-CMA with urticaria and anaphylaxis was 7%.

Methods: We enrolled children with IgE-CMA with cutaneous, respiratory, gastrointestinal and anaphylactic symptoms. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.005DOI Listing
December 2018
6 Reads

Preterm birth is associated with higher prevalence of wheeze and asthma in a selected population of Japanese children aged three years.

Allergol Immunopathol (Madr) 2018 Dec 17. Epub 2018 Dec 17.

Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.

Background: The present cross-sectional study investigated the associations between low birthweight (LBW), high birthweight, preterm birth (PTB), postterm birth, small for gestational age (SGA), and large for gestational age (LGA) and the prevalence of wheeze and asthma in Japanese children aged three years (age range, 33-54 months; mean age, 38.7 months).

Methods: Study subjects were 6364 children. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.004DOI Listing
December 2018
2 Reads

Predictive value of the number of adverse reaction episodes for the IgE-mediated food allergy diagnosis.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):277-281. Epub 2018 Dec 17.

Primary Care Pediatrics, ASL Salerno, Italy.

Introduction And Objectives: The reproducibility of the adverse reaction increases the suggestiveness of a history of food allergy. However, the positive predictive value (PPV) of multiple adverse reaction episodes for the diagnosis of IgE-mediated food allergy is not known. This evaluation was the objective of our study. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.006DOI Listing
December 2018
2 Reads

Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: Histopathological and biochemical findings.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):185-193. Epub 2018 Dec 6.

Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Asthma is a chronic inflammatory disease of the airways. In this study, we evaluated the anti-inflammatory effects of myrtenol on the inflammatory indices in the pulmonary parenchyma and airways and on the inflammatory and oxidative indices of the bronchoalveolar lavage fluid (BALF) of asthmatic rats.

Methods: The allergic asthma was induced by sensitization (two weeks) followed by the inhalation of ovalbumin (four weeks). Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.003DOI Listing
December 2018
3 Reads

Development of a tool for screening adverse food reactions and food allergy in Portuguese children.

Allergol Immunopathol (Madr) 2018 Nov 29. Epub 2018 Nov 29.

CICS - Health Sciences Research Centre, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal; Department of Allergy & Clinical Immunology, Cova da Beira Hospital Centre, Covilhã, Portugal. Electronic address:

Introduction And Objectives: A standardised questionnaire may be an excellent tool for epidemiological studies aiming at screening children with suspected food allergies. Thus, the aim of the present study was to develop a screening questionnaire for assessing children with suspected food allergy and to analyse its reproducibility.

Materials And Methods: A questionnaire of adverse food reactions was developed by literary review of similar questionnaires validated in other countries as well as less well defined, non-validated Portuguese questionnaires. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.008DOI Listing
November 2018
5 Reads

Changes in the prevalence of asthma and related risk factors in adolescents: Three surveys between 1994 and 2015.

Allergol Immunopathol (Madr) 2018 Nov 29. Epub 2018 Nov 29.

Hospital Del Salvador, Santiago, Chile.

Methods: This study assesses the temporal trend of current asthma symptoms prevalence and associated factors in Chilean adolescents from South-Santiago, considering surveys performed in 1994, 2002 and 2015.

Results: The prevalence of current asthma symptoms showed a trend to increase from 11.1% in 1994 to 13. Read More

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http://dx.doi.org/10.1016/j.aller.2018.10.001DOI Listing
November 2018
7 Reads

Increased IRF4 expression in isolated B cells from common variable immunodeficiency (CVID) patients.

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):52-59. Epub 2018 Nov 30.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by low serum levels of immunoglobulins (Igs) and recurrent infection. In most CVID patients, a defect in the differentiation of B cells into plasma cells has been observed. Several factors play an important role in the proliferation and differentiation of B cells, including IRF4 and XBP1 transcription factors. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.005DOI Listing
April 2019
6 Reads

Self-reported hypersensitivity and allergy to foods amongst Mexican adolescents: Prevalence and associated factors.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):246-253. Epub 2018 Nov 30.

Universidad Autónoma del Estado de México, Centro de Investigación en Ciencias Médicas, Estado de México, Jesús Carranza No. 205, Colonia Universidad, Toluca de Lerdo, Estado de México, C.P. 50130, Mexico.

Background: The prevalence of food allergy is on the rise on a global scale.

Objective: To determine the prevalence of food hypersensitivity (FHS) and probable food allergy (PFA), as well as the foods and factors associated with these occurrences.

Methods: A cross-sectional study was carried out among 1992 adolescents (aged 15-18 years). Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.004DOI Listing
November 2018
15 Reads

IgE-mediated allergic responses associated to Ailanthus altissima pollen using an animal model.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):272-276. Epub 2018 Nov 28.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Murine models have been widely used in the study of allergy as sensitized mice can produce IgE and/or IgG1in response after the injection of an antigen/adjuvant combination. Ailanthus altissima pollen (AAP) has been recently reported as an emerging aeroallergen in Iran. So far, several AAP candidate allergens by the screening of allergen-specific IgE in the sera from AAP sensitized patients in Iran. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.007DOI Listing
November 2018
3 Reads

The efficiency of the symptom-based score in infants diagnosed with cow's milk protein and hen's egg allergy.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):265-271. Epub 2018 Nov 27.

Dokuz Eylul University, Division of Pediatric Immunology and Allergy, Izmir, Turkey.

Introduction And Objectives: Symptom-based score (SBS) quantifies the number and severity of suspected cow's milk-related symptoms. In this study, we aimed to evaluate the efficiency of SBS in patients diagnosed with cow's milk protein (CMPA) and hen's egg allergy (HEA).

Materials And Methods: A single-center study was conducted between June 2015 and August 2017. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.006DOI Listing
November 2018
2 Reads

'Real-life' experience in asthmatic children treated with omalizumab up to six-years follow-up.

Allergol Immunopathol (Madr) 2018 Nov 30. Epub 2018 Nov 30.

Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

Introduction And Objectives: Omalizumab is present in international guidelines for the control of severe asthma, but data on the long-term effects in children are limited. Our objective was to perform a 'real-life' long-term trial of omalizumab in children with allergic asthma.

Materials And Methods: An observational single center 'real-life' study was performed. Read More

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http://dx.doi.org/10.1016/j.aller.2018.09.009DOI Listing
November 2018
5 Reads

Successful oral desensitization in children with cow's milk anaphylaxis: Clinical and laboratory evaluation up to nine-years follow-up.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):133-140. Epub 2018 Oct 25.

Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.

Introduction: Cow's milk protein allergy (CMPA) is the most common food allergy in children worldwide. Some children have severe and persistent CMPA, with near-fatal reactions after exposure to trace amounts of cow's milk-proteins (CMP). Strict avoidance diet is difficult, negatively affects quality of life and represents a conservative approach. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.007DOI Listing
October 2018
6 Reads

The effect of neonatal maternal separation on short-chain fatty acids and airway inflammation in adult asthma mice.

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):2-11. Epub 2018 Nov 17.

Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China; Teaching and Research Section of Pediatrics, Medical College, Southeast University, Nanjing, Jiangsu 210009, China. Electronic address:

Background: To investigate neonatal maternal separation (NMS) effects on airway inflammation of asthma and potential mechanism using a mouse model.

Methods: 80 Balb/c neonatal male mice were randomly assigned to NMS and non-NMS groups. Feces were collected on PND21, 28, 35 and 42 to analyze microbiota and short-chain fatty acids (SCFAs). Read More

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http://dx.doi.org/10.1016/j.aller.2018.05.004DOI Listing
April 2019
15 Reads

Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD4 T cells in allergic rhinitis.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):234-240. Epub 2018 Nov 16.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

Introduction And Objectives: Allergic rhinitis (AR) is a classic Th2-mediated disease, with important contributions to the pathology of interleukins 4, 5, and 13. The co-stimulatory molecule of OX40 and its ligand interaction participate in the immune response by regulation of Th1/Th2 cells balance. Considering the paucity of information on the relation between OX40 ligand (OX40L) and AR, this study aimed to examine its expression on B lymphocytes. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.003DOI Listing
November 2018
4 Reads

Evidence for respiratory viruses interactions in asymptomatic preschool-aged children.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):260-264. Epub 2018 Nov 16.

Third Department of Pediatrics, University General Hospital "Attikon", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Aim: To prospectively evaluate interferences between viruses of the upper respiratory tract in asymptomatic preschool children.

Methods: Nasal-pharyngeal swabs from 233 preschool aged children were prospectively collected over four consecutive time periods, during one school year. The samples were tested using a RT-PCR DNA/RNA microarray system for nine respiratory viruses. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.005DOI Listing
November 2018
2 Reads

Day-care center attendance and risk of Asthma-A systematic review.

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):578-584. Epub 2018 Jul 7.

Carlos Ochoa Sangrador; MD PhD; Hospital Virgen de la Concha. Avd. Requejo 35; 49022 Zamora, Spain; Alba Vazquez Blanco; Nurse; School of Nursing. Avd. Requejo 33; 49022 Zamora, Spain.

Introduction And Objectives: Asthma and other wheezing disorders are common chronic health problems in childhood. We aim to evaluate whether the attendance by children under three years of age to day-care centers is a protector or risk factor in the development of recurrent wheezing or asthma in the following years of their lives.

Methods: Systematic review of published cohort or cross-sectional studies, without any time limitation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010546183007
Publisher Site
http://dx.doi.org/10.1016/j.aller.2018.03.006DOI Listing
January 2019
15 Reads

Focus group parental opinions regarding treatment with topical corticosteroids on children with atopic dermatitis.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):166-171. Epub 2018 Oct 10.

Department of Paediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands. Electronic address:

Introduction And Objectives: Atopic dermatitis is common among children of 0-5 years old. Treatment consists of emollients and topical corticosteroids. Due to corticophobia, however, adherence to topical corticosteroids is low. Read More

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http://dx.doi.org/10.1016/j.aller.2018.05.007DOI Listing
October 2018
2 Reads

Cooking influence in tolerance acquisition in egg-induced acute food protein enterocolitis syndrome.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):221-226. Epub 2018 Oct 11.

Allergy Unit, Pediatrics Area, Department of Woman and Child Health, Università Cattolica del Sacro Cuore, Policlinico Gemelli Foundation, Rome, Italy.

Background: Few studies on the age of resolution of Food Protein Induced Enterocolitis Syndrome (FPIES) induced by solid foods are available. In particular, for FPIES induced by egg, the mean age of tolerance acquisition reported in the literature ranges from 42 to 63 months.

Objective: We have assessed whether the age of tolerance acquisition in acute egg FPIES varies depending on whether the egg is cooked or raw. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010546183011
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http://dx.doi.org/10.1016/j.aller.2018.07.006DOI Listing
October 2018
17 Reads

This is what scientific societies are for. The CIBAL consensus.

Authors:
L Garcia-Marcos

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):515-516

Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia, Spain; IMIB Bio-health Research Institute, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.aller.2018.09.001DOI Listing
January 2019
2 Reads

Osteoprotegerin mediate RANK/RANKL signaling inhibition eases asthma inflammatory reaction by affecting the survival and function of dendritic cells.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):179-184. Epub 2018 Oct 3.

Department of Respiratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Electronic address:

Introduction: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Dendritic cells (DCs) are considered the most important antigen-presenting cell in asthma airway inflammatory reaction. But whether osteoprotegerin (OPG) mediate RANK/RANKL signaling inhibition influences asthma development by affecting the survival and function of DCs remains unclear. Read More

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http://dx.doi.org/10.1016/j.aller.2018.06.006DOI Listing
October 2018
3 Reads

Microdeletion 22q11.2 syndrome: Does thymus incidental surgical resection affect its immunological profile?

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):141-151. Epub 2018 Oct 3.

Departamento de Genética, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico.

Background: The del22q11 syndrome patients present immunological abnormalities associated to thymus alterations. Up to 75% of them present cardiopathies and thymus is frequently removed during surgery. The thymectomy per se has a deleterious effect concerning lymphocyte subpopulations, and T cell function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03010546183011
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http://dx.doi.org/10.1016/j.aller.2018.06.004DOI Listing
October 2018
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Phenotyping and long-term follow up of patients with hyper IgE syndrome.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):152-158. Epub 2018 Sep 29.

Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction And Objectives: Long-term follow up of patients with hyper IgE syndrome (HIES), as a primary immunodeficiency disorder, has been poorly investigated. This study describes common clinical and immunological features of patients with HIES in the last 10 years in Shiraz University of Medical Sciences, Shiraz, Iran.

Methods And Patients: In this cross-sectional study, the symptoms and medical records of 18 patients, who were diagnosed with HIES, were observed. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.009DOI Listing
September 2018
3 Reads

Taurine administration prevents the intestine from the damage induced by beta-lactoglobulin sensitization in a murine model of food allergy.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):214-220. Epub 2018 Sep 27.

Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, University of Oran1 Ahmed Ben Bella, 31000 Oran, Algeria.

Background: Allergy to cow's milk proteins has often been associated with dysfunction of the intestinal mucosa caused by chronic inflammation in infants. This study evaluated the protective effect of taurine on intestinal damage induced by beta-lactoglobulin (β-Lg) in Balb/c mice used as an animal model of allergy to cow's milk proteins.

Methods: Balb/c mice were treated with taurine administered orally by gavage (3mmol/kg/day) or intraperitoneally (100mg/kg/day) for two weeks, then sensitized intraperitoneally with β-Lg. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.010DOI Listing
September 2018
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Current therapeutic paradigm in pediatric atopic dermatitis: Practical guidance from a national expert panel.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):194-206. Epub 2018 Sep 26.

Pediatric Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy.

Introduction And Objectives: Atopic dermatitis (AD) is the most common cutaneous inflammatory disease in both adults and children. Although emerging therapeutic approaches are being investigated for the management of pediatric AD, it still needs to be managed with conventional treatments. This consensus document is aimed at providing an update on general management and therapies of pediatric AD, defining practical recommendations for using both topical and systemic agents. Read More

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http://dx.doi.org/10.1016/j.aller.2018.06.008DOI Listing
September 2018
4 Reads

Evaluation of interleukin-12 receptor β1 and interferon gamma receptor 1 deficiency in patients with disseminated BCG infection.

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):38-42. Epub 2018 Sep 27.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Infectious Diseases, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Disseminated BCG infections among other complications of Bacillus Calmette-Guérin (BCG) vaccine are rare and have occurred in children with immunodeficiency disorders such as mendelian susceptibility to mycobacterial disease (MSMD) which could be due to defects in some elements of IL-12/IFN-γ axis. MSMD-causing mutations have been identified in 10 genes during the last two decades. Among them, mutations in the IL12Rβ1 and IFNγR1 genes constitute about 80% of recorded cases of MSMD syndrome. Read More

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http://dx.doi.org/10.1016/j.aller.2018.06.005DOI Listing
April 2019
15 Reads

Association of M470V polymorphism of CFTR gene with variability of clinical expression of asthma: Case-report study.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):159-165. Epub 2018 Sep 27.

Biochemistry Laboratory (LR00SP03), Children's Hospital, Tunis, Tunisia. Electronic address:

Introduction And Objectives: Asthma is a complex genetic disorder. Several genes have been found associated with asthma. The cystic fibrosis transmembrane conductance regulator (CFTR) gene is one of them. Read More

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http://dx.doi.org/10.1016/j.aller.2018.06.007DOI Listing
September 2018
12 Reads

Th17 cells in Bulgarian children with chronic obstructive lung diseases.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):227-233. Epub 2018 Sep 24.

Pediatric Clinic, University Hospital Alexandrovska, Medical University of Sofia, Sofia, Bulgaria.

Introduction And Objectives: Th17 lymphocytes are now widely believed to be critical in various chronic pulmonary diseases. However, there is still a small number of investigations regarding children. We aimed to assess the percentage of Th17 lymphocytes and IL-17A in peripheral blood of children with chronic obstructive lung diseases. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.004DOI Listing
September 2018
14 Reads

Thrombin lag time is increased in children with mild asthma.

Allergol Immunopathol (Madr) 2019 May - Jun;47(3):241-245. Epub 2018 Sep 24.

Department of Pediatric Allergy, Baskent University, Faculty of Medicine, Ankara, Turkey.

Background: Inflammation and coagulation are closely linked events. Thrombin is the key enzyme in coagulation system and also has roles in inflammation.

Objective: The aim of our study was to evaluate thrombin generation in children with mild asthma. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.002DOI Listing
September 2018
3 Reads

Anaphylaxis to beta-lactam antibiotics at pediatric age: Six-year survey.

Allergol Immunopathol (Madr) 2019 Mar - Apr;47(2):128-132. Epub 2018 Sep 21.

Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal.

Introduction: Beta-lactams are the most frequently used antibiotics in pediatric age. Anaphylactic reactions may occur and need to be properly studied, but studies in children are scarce.

Objective: Characterization of case reports of anaphylaxis in children referred to an allergy department with suspected beta-lactams hypersensitivity. Read More

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http://dx.doi.org/10.1016/j.aller.2018.07.008DOI Listing
September 2018
6 Reads

Molecular diagnostics improves diagnosis and treatment of respiratory allergy and food allergy with economic optimization and cost saving.

Allergol Immunopathol (Madr) 2019 Jan - Feb;47(1):64-72. Epub 2018 Sep 20.

Departmental Unit of Allergology, AUSL of Piacenza, "Guglielmo da Saliceto" Hospital, Piacenza, Italy.

Background: Component resolved diagnosis (CRD) allows to precisely identify the sensitization to specific molecules of a given allergenic source, resulting in an important improvement in clinical management, particularly of polysensitized subjects. This will end in the correct prescription of allergen immunotherapy (AIT) for respiratory allergy and in adequate avoidance diets or prescription of self-injectable adrenaline in food allergy.

Objective: The aim of this multicenter, real life study is to evaluate the percentage change of the diagnostic-therapeutic choice in polysensitized patients with respiratory allergy and in patients with food allergy, after using CRD compared to a first level diagnosis, along with an economic analysis of the patient's overall management according to the two different approaches. Read More

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http://dx.doi.org/10.1016/j.aller.2018.05.008DOI Listing
April 2019
5 Reads