3,189 results match your criteria Allergologia Et Immunopathologia[Journal]

Mechanism of Rhizoma Coptidis in epilepsy with network pharmacology.

Allergol Immunopathol (Madr) 2022 1;50(3):138-150. Epub 2022 May 1.

Department of Neurology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China;

Network pharmacology is a bioinformatics-based research strategy aimed at identifying drug actions and facilitating drug discovery. In this study, network pharmacology was used for exploring the anti-epileptic multi-target mechanism of Rhizoma Coptidis. The possible protein targets of Rhizoma Coptidis were predicted by constructing the pathway and network of drug targets. Read More

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Safety of an inactivated COVID-19 vaccine in patients with - wheat-dependent exercise-induced anaphylaxis.

Zhirong Du Jia Yin

Allergol Immunopathol (Madr) 2022 1;50(3):132-137. Epub 2022 May 1.

Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, Beijing, China.

Background: Inactivated vaccines against coronavirus disease-2019 (COVID-19) offer an effective public health intervention to mitigate this devastating pandemic. However, little is known about their safety in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA).

Methods: We recruited 72 WDEIA patients and 730 healthy matched controls who received an inactivated COVID-19 vaccine. Read More

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The comparative effect of Leukotriene receptor antagonist add on therapy and step up inhaled Corticosteroid in partially controlled asthma: An open-labeled randomized controlled trial.

Allergol Immunopathol (Madr) 2022 1;50(3):125-131. Epub 2022 May 1.

Division of Pulmonary, Critical Care and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Background: No studies are comparing the impact of the add-on leukotriene-receptor antagonist (LTRA) with a step-up dose of inhaled corticosteroids (ICS) in partly controlled asthma patients with asthma control test (ACT) score ˂ 23.

Objective: To study the effect of LTRA add-on therapy in comparison to a step-up to medium dose of ICS in partially controlled asthma.

Methods: An open-labeled randomized controlled trial was conducted in asthma subjects with partly controlled asthma who had been in regular receipt of low dose ICS. Read More

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PTPRO activates TLR4/NF-κB signaling to intensify lipopolysaccharide-induced pneumonia cell injury.

Yao Chen Buming Sun

Allergol Immunopathol (Madr) 2022 1;50(3):119-124. Epub 2022 May 1.

Department of Pediatric, Huai'an Second People's Hospital, Huai'an, China;

Background: Protein tyrosine phosphatase receptor type O (PTPRO) belongs to the PTP (protein tyrosine phosphatase) family and is widely expressed in parenchymal cells, such as breast and lung epithelial cells. PTPRO has been shown to enhance inflammatory responses and has been implicated in the pathogenesis of inflammation-associated diseases. The role of PTPRO in pneumonia was investigated. Read More

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Tricin attenuates the progression of LPS-induced severe pneumonia in bronchial epithelial cells by regulating AKT and MAPK signaling pathways.

Allergol Immunopathol (Madr) 2022 1;50(3):113-118. Epub 2022 May 1.

Department of Critical Care Medicine, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China;

Background: Pneumonia is a continuous and widespread disease with higher incidence, the effects of it on human life can be fearful. Tricin has been demonstrated to take part in the progression and development of diseases. However, the function of Tricin and its related regulatory pathways remain unclear. Read More

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Knockdown of EPSTI1 alleviates lipopolysaccharide-induced inflammatory injury through regulation of NF-κB signaling in a cellular pneumonia model.

Allergol Immunopathol (Madr) 2022 1;50(3):106-112. Epub 2022 May 1.

Pediatric Intensive Care Unit, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;

Background: Although early diagnosis, antibiotic therapies, corticosteroid application, and health care services are conventional managements for pneumonia, antibiotic resistance and adverse reactions remain as limitations for pneumonia treatment.

Objectives: The study attempted to evaluate the potential role of EPSTI1 against pneumonia and reveal its underlying mechanism.

Methods: Lipopolysaccharide (LPS) (5, 10, and 20 μg/mL) was applied in WI-38 cells to establish the pneumonia model. Read More

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Easy approach to detect cell immunity to COVID vaccines in common variable immunodeficiency patients.

Allergol Immunopathol (Madr) 2022 1;50(3):101-105. Epub 2022 May 1.

Department of Allergy, Hospital Universitario de Canarias, San Cristóbal de La Laguna, Spain;

Background: Patients with primary antibody deficiencies, such as Common Variable Immunodeficiency (CVID), have some problems to assess immune response after coronavirus disease (COVID) vaccination. Cutaneous delayed-type hypersensitivity (DTH) has the potential to be used as a useful, simple, and cheaper tool to assess T-cell (T lymphocyte) function.

Methods: Seventeen patients with CVID, a rare disease, received two doses of the mRNA-based Pfizer-BioNTech COVID-19 vaccine. Read More

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Survey of immunopharmacological effects of botulinum toxin in cell signaling of bronchial smooth muscle cells in allergic asthma.

Allergol Immunopathol (Madr) 2022 1;50(3):93-100. Epub 2022 May 1.

Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran;

Background: Asthma is a lung disease that has influenced more than 350 million people worldwide. Airway smooth muscle (ASM) spasm leads to airway hyperresponsiveness (AHR) and bronchial obstruction, which are clinical manifestations of an asthma attack. Botulinum toxin (BTX) is a bacteria toxin that acts as muscle relaxant and may have therapeutic effects on AHR and asthma. Read More

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Dexmedetomidine reduces dextran sulfate sodium (DSS)-induced NCM460 cell inflammation and barrier damage by inhibiting RhoA/ROCK signaling pathway.

Allergol Immunopathol (Madr) 2022 1;50(3):85-92. Epub 2022 May 1.

Department of Gastroenterology, Lishui City People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Zhejiang Province, Lishui, China;

Objective: This study investigated the role of dexmedetomidine (DEX) in dextran sulfate sodium (DSS)-induced NCM460 cells.

Material And Methods: The viability and apoptosis of NCM460 cells treated with DEX with or without DSS were detected by CCK-8 and terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) assay. The level of inflammatory factors and expression of inflammation-related proteins, tight junction proteins and Ras homolog gene family, member A/Rho-associated coiled-coil containing protein kinase (RhoA/ROCK) signaling-related proteins in NCM460 cells treated with DEX and/or U46619 (RhoA/ROCK agonist) and/or DSS were detected by the respective enzyme-linked immunosorbent assay (ELISA) kits and Western blot analysis. Read More

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Allergy clinic patients' drug hypersensitivity.

Allergol Immunopathol (Madr) 2022 1;50(3):77-84. Epub 2022 May 1.

Immunology and Allergy Clinic, Medical University of Lodz, Poland.

Background: Drug hypersensitivity reaction (DHR) is a common reason for an allergology con- sultation, during which it is not only necessary to gather a thorough medical history, but also to propose and perform diagnostic tests.

Objectives: The aim of the study was to retrospectively assess the patients with a profile of preliminary drug hypersensitivity diagnosis, the usefulness of NSAID hypersensitivity classifica- tion in outpatient practice, and to analyze the results of skin, provocation, and drug tolerance tests performed in Immunology and Allergy Clinic patients.

Methods: Around 501 medical records of patients referred to the academic allergy outpatient clinic from 2011 to 2019, and had a preliminary drug hypersensitivity diagnosis were analyzed. Read More

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PLCE1 alleviates lipopolysaccharide-induced acute lung injury by inhibiting PKC and NF-κB signaling pathways.

Allergol Immunopathol (Madr) 2022 1;50(3):71-76. Epub 2022 May 1.

Department of Respiratory Medicine, Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China;

Background: Acute lung injury (ALI) is a clinical syndrome characterized by hyperosmotic pulmonary edema and increased alveolar fluid. Phospholipase C epsilon-1 (PLCE1), identified as a member of phospholipase family, and the relationship between PLCE1 and lung injury is not clear.

Objective: To assess the possible role of Phospholipase C Epsilon 1 (PLCE1) in Acute lung injury (ALI) progression and related mechanisms. Read More

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Momordica charantia polysaccharides alleviate diarrhea-predominant irritable bowel syndrome by regulating intestinal inflammation and barrier via NF-κB pathway.

Allergol Immunopathol (Madr) 2022 1;50(3):62-70. Epub 2022 May 1.

Department of Digestive Internal Medicine, Lianyungang Hospital of Traditional Chinese Medicine, Lianyungang, Jiangsu, China;

Background: Momordica charantia exerts anti-inflammatory effect against ulcerative colitis. Momordica charantia polysaccharides (MCPs) attenuate gastritis through inhibition of ethanol-induced inflammatory response.

Objective: The role of MCPs in diarrhea-predominant irritable bowel syndrome (IBS-D) is investigated. Read More

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Severity of disease and the quality of life indexes in infants with atopic dermatitis.

Allergol Immunopathol (Madr) 2022 1;50(3):55-61. Epub 2022 May 1.

Pediatric Allergy and Immunology Clinic, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Background: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease. In this study, the relationship between the severity of AD and the quality of life (QoL) of patients and their families were evaluated; also, the factors that predict the severity of AD and the QoL index were determined.

Methods: Infants with AD were enrolled in the study. Read More

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Therapeutic effects of acupuncture in rheumatoid arthritis are associated with centromere protein F expression.

Allergol Immunopathol (Madr) 2022 1;50(3):47-54. Epub 2022 May 1.

Department of Rheumatology Immunohematology, Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, China;

Objective: The objective of this study is to study the critical role of CENPF in regulation of rheumatoid arthritis with acupuncture treatment.

Methods: PCA was used to analyze the different expression genes between AP treatment group and control group. Volcano plot and random forest model were used to analyze the decreased and increased expression genes. Read More

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Dedicator of cytokinesis protein 2 knockdown ameliorates LPS-induced acute lung injury by modulating Rac1/2 activity.

Yan Zhou Wan Hu

Allergol Immunopathol (Madr) 2022 1;50(3):38-46. Epub 2022 May 1.

Department of Respiratory and Critical Care Medicine, Zhuhai People's Hospital, Zhuhai, Guangdong, P.R. China;

Dedicator of cytokinesis protein 2 (DOCK2) is a member of the cytoskeletal dynamics protein family, and is ubiquitously expressed in hematopoietic cells according to previous studies. This paper was intended to explore the underlying mechanism that DOCK2 might involve in the progression of acute lung injury (ALI). Following lipopolysaccharide (LPS) induction in the purchased A549 cells, the expression level of DOCK2 was determined and its knockdown was performed by transfection. Read More

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Systematic review and meta-analysis of probiotics in the treatment of allergic rhinitis.

Allergol Immunopathol (Madr) 2022 1;50(3):24-37. Epub 2022 May 1.

The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China;

Background: The purpose of this meta-analysis is to systematically evaluate the efficacy of probiotics on allergic rhinitis (AR).

Methods: Collecting randomized controlled trials (RCTs) with probiotics as intervention measures for AR, two researchers independently screened the literature, extracted the data and evaluated the methodological quality of the included studies, and used RevMan 5.3 software for meta-analysis to observe the effects of probiotics on Rhinitis Quality of Life (RQLQ) scores, Rhinitis Total Symptom Scores (RTSS), blood eosinophil count, total and antigen-specific serum immunoglobulin E (IgE) levels by using the fixed- or the random-effects model to calculate the pooled risk for significant heterogeneity. Read More

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lnc-THRIL and miR-125b relate to disease risk, severity, and imbalance of Th1 cells/Th2 cells in allergic rhinitis.

Allergol Immunopathol (Madr) 2022 1;50(3):15-23. Epub 2022 May 1.

Department of Otorhinolaryngology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi, China;

Objective: Tumor necrosis factor and HNRNPL-related immunoregulatory long noncoding RNA (lnc-THRIL) and its target microRNA (miR)-125b are reported to regulate immune response through several means by participating in allergic rhinitis (AR) pathology. This study aimed to investigate the role of lnc-THRIL and miR-125b in detecting AR risk, and to further explore their correlation with disease severity and cytokines released from T helper type (Th) 1 and Th2 in AR patients.

Methods: A total of 160 AR patients and 80 subjects with severe snoring symptoms (as controls) were recruited. Read More

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Primary care experience on Stimunex gocce in children with recurrent respiratory infections: a real-world study during the COVID-19 pandemic era.

Allergol Immunopathol (Madr) 2022 1;50(3):8-14. Epub 2022 May 1.

Allergy Clinic, Villa Serena, Genoa, Italy;

Background: Respiratory infections (RI) significantly burden society, mainly when there are recurrent respiratory infections (RRI). Thus, there is a need to prevent RI in clinical practice. In this regard, the modulation of the immune system and resolution of the inflammatory cascade could represent an ideal way to prevent RI. Read More

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Long-term outcome of omalizumab-assisted desensitisation to cow's milk and eggs in patients refractory to conventional oral immunotherapy: real-life study.

Allergol Immunopathol (Madr) 2022 1;50(3):1-7. Epub 2022 May 1.

Paediatric Allergies, Immunology and Pneumology Unit, Paediatric Medicine Service, Parc Tauli Hospital Universitari. Institut d'Investigació i Innovació Parc Tauli (I3PT). Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain.

Background: Oral immunotherapy (OIT) is a promising approach to cow's milk and egg allergies, but reactions are frequent and some patients cannot be desensitized.

Objective: To evaluate long-term OIT outcomes with omalizumab (OMZ) in paediatric patients with severe egg and/or milk allergies.

Methods: This retrospective real-life study analysed findings in children with Immunoglobulin E-mediated allergy to cow's milk and/or hen eggs refractory to conventional OIT, who underwent OIT with OMZ in our department between 1 January 2010 and 31 December 2015. Read More

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Knockdown of GPRC5B alleviates the high glucose-induced inflammation and extracellular matrix deposition of podocyte through inhibiting NF-κB pathway.

Allergol Immunopathol (Madr) 2022 1;50(2):142-146. Epub 2022 Mar 1.

Department of Nephrology, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China;

Background: Diabetes is a serious disease that could greatly increase the risk of cardiovascular complications, whereas the underlying pathology of DN is still unknown. GPRC5B is a member of the RAIG subfamily of type 3 (family C) GPCR, and its role in DN is still unclear.

Objective: To unveil the role of GPRC5B in diabetic nephropathy (DN) progression and investigate the potential signaling pathway. Read More

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Association between allergen component sensitisation and clinical allergic disease in children.

Allergol Immunopathol (Madr) 2022 1;50(2):131-141. Epub 2022 Mar 1.

Central Laboratory, Isala Hospital, Zwolle, The Netherlands;

Background: Allergen component sensitisation testing is becoming increasingly important in the diagnosis of peanut allergy. The aim of the present study was to evaluate the relationship between sensitisation and symptoms of allergic disease in children by testing a large panel of inhalants, food allergens, and allergen components.

Methods: For 287 children visiting our laboratory for allergy testing, symptoms of allergic disease were recorded by standardised validated questionnaires. Read More

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Impact of allergic reactions and urticaria on mental health and quality of life.

Allergol Immunopathol (Madr) 2022 1;50(2):124-130. Epub 2022 Mar 1.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany.

Background: Allergic diseases represent a major global health issue with more than one-third of the global population affected by at least one allergic condition. Allergic conditions can not only cause life-threatening anaphylactic reactions but also impact daily life with a significant influence on mental health and the quality of life (QoL).

Objectives: This study aims to evaluate the health-related QoL and depression severity among patients presenting in a tertiary care allergy center. Read More

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L. improves airway hyperresponsiveness and suppresses inflammation in a murine model of allergic asthma.

Allergol Immunopathol (Madr) 2022 1;50(2):115-123. Epub 2022 Mar 1.

Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil;

Objective: To evaluate the effect of a hydroethanolic extract of L. ("bitter melon", Cucurbitaceae) leaves (MCHA) on ovalbumin (OVA)-induced asthma model. Balb/c mice were sensitized twice and challenged for 4 alternate days with OVA and then treated with MCHA (500 mg/kg) for 7 consecutive days. Read More

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6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1.

Allergol Immunopathol (Madr) 2022 1;50(2):104-114. Epub 2022 Mar 1.

The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, China;

Pulmonary fibrosis in general is the final common outcome of various interstitial lung diseases. In recent years, the incidence of pulmonary fibrosis has been rising with poor prognosis. 6-gingerol is deemed as a functional polyphenol of ginger. Read More

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Ubiquitin-specific protease 8 inhibits lipopolysaccharide-triggered pyroptosis of human bronchial epithelial cells by regulating PI3K/AKT and NF-κB pathways.

Allergol Immunopathol (Madr) 2022 1;50(2):96-103. Epub 2022 Mar 1.

Department of Respiratory and Critical Care Medicine, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, China.

Asthma, characterized by dysfunction of airway epithelial cells, is regarded as a chronic inflammatory disorder in the airway. Ubiquitin-specific protease 8 (USP8) belongs to ubiquitin proteasome system and mediates the stability of E3 ligases. The anti-inflammatory effect of USP8 has been widely investigated in distinct diseases, while the role of USP8 in asthma remains elusive. Read More

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The traditional Mediterranean diet is effective in the prevention and treatment of acute and recurrent inflammatory diseases of childhood.

Allergol Immunopathol (Madr) 2022 1;50(2):93-95. Epub 2022 Mar 1.

Child and Adolescent Clinic "La Palma", Ciudad Real, Spain;

In the recent SARS-CoV-2 pandemic, disease severity was found to be more related to the immune system hyper-response than the invasive or destructive capacity of the virus. Similarly, most common childhood diseases, which are generally recurrent and inflammatory, may be caused by a hyper-response or inability of the immune system. Individuals will react differently to causal noxa and outcomes will depend on the balance and maturity of their immune system. Read More

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Investigation of the sensitization rate for gibberellin-regulated protein in patients with Japanese cedar pollinosis.

Allergol Immunopathol (Madr) 2022 1;50(2):89-92. Epub 2022 Mar 1.

Department of Pediatrics, School of Medicine, Fujita Health University, Aichi, Japan;

Background: Pollen-food allergy syndrome (PFAS) usually manifests as an itching sensation in the mouth and throat immediately after eating fresh fruits and vegetables. However, some patients with PFAS experience systemic symptoms including anaphylaxis. In Europe, cypress gibberellin-regulated protein (GRP) has been noted to cause allergenicity and exhibit cross-reactivity with peach GRP. Read More

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Psychological stress in asthma: repercussions on epigenetics-genetics, immune responses, and pulmonary function in the pediatric population.

Allergol Immunopathol (Madr) 2022 1;50(2):78-88. Epub 2022 Mar 1.

Department of Pediatrics, Federal University of Pernambuco (UFPE), Pernambuco, Brazil.

In the assessment of childhood asthma, identifying the risk factors associated with exacerbations and broadening this view to understand psychological stress and its repercussions on the inflammatory process of asthma allow a different perspective on this biopsychosocial disease. Psychological stress, as a risk factor for the onset and noncontrol of asthma, has been increasingly evaluated from the perspective of the repercussions on the body of the stimulus generated in the hypothalamic-pituitary axis and adrenal glands, with cortisol release and immune system action. These processes trigger changes in T helper 2 cells, which polarize allergic processes, and dysfunctions in immune tolerance mechanisms, with a decrease in regulatory T cells. Read More

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Persistence of airborne tree pollen from the family during the last decade in the city of Bahia Blanca.

Allergol Immunopathol (Madr) 2022 1;50(2):75-77. Epub 2022 Mar 1.

Department of Medicine, Universidad Espíritu Santo, Samborondón, Ecuador.

Airborne pollen is a major contributor to allergic respiratory diseases. However, the literature on patterns and seasonality of specific pollen types mainly comes from northern hemisphere and developed regions, limiting our ability to extrapolate these findings to other geographical locations. With this research letter, our aim is to contribute to the current knowledge of aerobiology by analyzing the decade-long patterns of airborne tree pollen in the city of Bahia Blanca, Argentina. Read More

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Three-year pollen and fungi calendar in a Mediterranean region of the Northeast Greece.

Allergol Immunopathol (Madr) 2022 1;50(2):65-74. Epub 2022 Mar 1.

Department of Otorhinolaryngology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Introduction And Objectives: Pollen calendars have been proved clinically important in allergic disease management, as differences in airborne allergens exist not only between different countries but also between regions of the same country as well. This study aims to provide new data regarding the atmospheric pollen and fungi content of a Mediterranean region (Western Thrace/North-East Greece) and discuss seasonal trends, differences in pollen grains and fungi spores' circulation over the years, and correlations with climate parameters.

Material And Methods: A 7-day continuously running volumetric trap was used to collect circulating pollen grains and fungi spores. Read More

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