85 results match your criteria Allergo journal international[Journal]


Novel vaccines targeting dendritic cells by coupling allergoids to mannan.

Allergo J Int 2018 18;27(8):256-262. Epub 2018 May 18.

1Department of Biochemistry and Molecular Biology, School of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain.

Allergen-specific immunotherapy (AIT) is the single disease-modifying treatment for allergy. Clinical trials show AIT to be safe and effective for many patients; however, it still faces problems related to efficacy, safety, long treatment duration and low patient adherence. There has been intensive research to develop alternative strategies, including novel administration routes, adjuvants or hypoallergenic molecules. Read More

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http://dx.doi.org/10.1007/s40629-018-0069-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267119PMC
May 2018
2 Reads

Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.

Allergo J Int 2018 9;27(8):245-255. Epub 2018 Jul 9.

9Jenner Institute, University of Oxford, Oxford, UK.

Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Read More

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http://dx.doi.org/10.1007/s40629-018-0074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267129PMC
July 2018
1 Read

Long-acting muscarinic antagonists for the treatment of asthma in children-a new kid in town.

Authors:
Eckard Hamelmann

Allergo J Int 2018 26;27(7):220-227. Epub 2018 Apr 26.

Kinderzentrum Bethel, Evangelisches Klinikum Bethel, Grenzweg 10, 33617 Bielefeld, Germany.

Background: Asthma is the most prevalent chronic airway disease observed in children and adolescents, yet the variety of treatment options available for this age group is limited. With many factors influencing therapeutic efficacy including patient knowledge, adherence, and therapy choice as well as delivery device, it is important to have more options to tailor to individual patient needs.

Methods: This article is an overview of recent scientific articles using a systematic literature search in PubMed and specialist databases. Read More

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http://dx.doi.org/10.1007/s40629-018-0066-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208794PMC
April 2018
1 Read

Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI).

Allergo J Int 2018 28;27(5):147-151. Epub 2018 May 28.

10Department of Dermatology, Venereology and Allergology, Allergy Center Charité (ACC), Charité University Hospital, Berlin, Germany.

Within the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. Read More

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http://link.springer.com/10.1007/s40629-018-0070-2
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http://dx.doi.org/10.1007/s40629-018-0070-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153714PMC
May 2018
162 Reads

SCIT with a high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups.

Allergo J Int 2018 25;27(5):131-139. Epub 2018 Jul 25.

2Allergopharma GmbH & Co. KG, Reinbek bei Hamburg, Germany.

Background: Efficacy of house dust mite (HDM) allergen immunotherapy (AIT) in allergic rhinitis and controlled allergic asthma has been documented in controlled trials with adults and children. However, tolerability comparing clinical development and post marketing data, particularly in different subgroups, is missing.

Methods: We performed an analysis of pooled safety data for subcutaneous AIT (SCIT) with a high-dose house dust mite allergoid from 6 randomized, controlled trials (RCT) in HDM allergic respiratory disease (ARD) and of post marketing safety data from more than 10 years including different subgroups (age, gender, asthma status). Read More

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http://link.springer.com/10.1007/s40629-018-0059-x
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http://dx.doi.org/10.1007/s40629-018-0059-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153715PMC
July 2018
5 Reads

Positive and negative AIT trials: What makes the difference?

Allergo J Int 2018 24;27(6):167-172. Epub 2018 May 24.

Section of Allergology, Department of Internal Medicine, Erasmus Medical Centre, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

Background: Allergen immunotherapy has proven to be efficacious in allergic rhinitis and asthma. However, results from randomised clinical trials may vary substantially. Clinical trials may unexpectedly fail. Read More

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http://dx.doi.org/10.1007/s40629-018-0058-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132372PMC
May 2018
1 Read

Placebo effects in allergen immunotherapy: an experts' opinion.

Allergo J Int 2018 24;27(6):162-166. Epub 2018 May 24.

2Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Placebo effects are common in medicine. Randomised clinical trials help us to understand their magnitude in different therapies. There are particular problems with placebo effects in allergen immunotherapy (AIT) as it is difficult to blind the active treatment and the endpoints are largely subjective. Read More

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http://dx.doi.org/10.1007/s40629-018-0065-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132371PMC
May 2018
1 Read

Perioperative drug reactions - practical recommendations for allergy testing and patient management.

Allergo J Int 2018 4;27(4):126-129. Epub 2018 Jun 4.

2Department of Dermatology and Allergology am Biederstein, Technical University of Munich, Munich, Germany.

Background: Allergy testing for perioperative drug reactions poses a particular diagnostic challenge. Neuromuscular blocking agents (NMBA) and antibiotics are among the most common triggers. In principle, however, any drug administered perioperatively is capable of causing a hypersensitivity reaction. Read More

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http://dx.doi.org/10.1007/s40629-018-0071-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004007PMC
June 2018
11 Reads

NSAID hypersensitivity - recommendations for diagnostic work up and patient management.

Authors:
Stefan Wöhrl

Allergo J Int 2018 25;27(4):114-121. Epub 2018 May 25.

Floridsdorf Allergy Center (FAZ), Pius-Parsch-Platz 1/3, 1210 Vienna, Austria.

Background: Adverse drug reactions (ADR) to analgesics (i.e., non-steroidal anti-inflammatory drug hypersensitivity, NSAID-HS) are one of the most common ADR, affecting approximately 1. Read More

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http://dx.doi.org/10.1007/s40629-018-0064-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004000PMC
May 2018
15 Reads

Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease.

Allergo J Int 2018 20;27(3):72-78. Epub 2018 Feb 20.

1The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria.

Introduction: Vitamins A and D are able to modulate innate and adaptive immune responses and may therefore influence the development and the course of allergic diseases.

Materials And Methods: This article reviews the current evidence for the experimental effects of vitamins A and D in animal models and on immune cells , and discusses their translational implication. A systematic literature search over the last 10 years was performed using MEDLINE and PubMed databases. Read More

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http://dx.doi.org/10.1007/s40629-018-0054-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910477PMC
February 2018

Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities.

Allergo J Int 2018 22;27(2):56-65. Epub 2018 Jan 22.

1Lübeck Campus, Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538 Lübeck, Germany.

Background: Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification for this disorder. A phenotype classification according to CRS with (CRSwNP) and without polyposis (CRSsNP) is usually made. Read More

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http://dx.doi.org/10.1007/s40629-017-0048-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842507PMC
January 2018
2 Reads

Current state of follow-up care for patients with Hymenoptera venom anaphylaxis in southwest Germany: Major impact of early information.

Allergo J Int 2018 16;27(1):4-14. Epub 2018 Jan 16.

1Department of Dermatology, Allergy Research Group, Medical Center, University of Freiburg, Freiburg, Germany.

Background: Up to 3.5% of the population experience anaphylactic reactions in response to Hymenoptera stings. Current guidelines are in place for the diagnostic workup and follow-up care of patients with Hymenoptera venom anaphylaxis (HVA). Read More

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http://link.springer.com/10.1007/s40629-017-0046-7
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http://dx.doi.org/10.1007/s40629-017-0046-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785614PMC
January 2018
5 Reads

New trends in anaphylaxis.

Allergo J Int 2017 15;26(8):295-300. Epub 2017 Nov 15.

Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. Read More

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http://dx.doi.org/10.1007/s40629-017-0042-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705757PMC
November 2017
7 Reads

Current concepts in eosinophilic esophagitis.

Allergo J Int 2017 13;26(7):258-266. Epub 2017 Sep 13.

Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland.

Background: Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration.

Methods: This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE.

Results: EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Read More

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http://dx.doi.org/10.1007/s40629-017-0037-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660132PMC
September 2017
4 Reads

Course of respiratory allergy by treatment strategy based on German routine data.

Allergo J Int 2017 30;26(6):195-203. Epub 2017 May 30.

Institute for Health Care Management and Research, University of Duisburg-Essen, Essen, Germany.

Purpose: Allergic respiratory diseases represent a global health problem. The two major treatment strategies are symptom treatment and specific immunotherapy (SIT). SIT is considered the only causal treatment option available with the ability to alter the course of the disease. Read More

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http://dx.doi.org/10.1007/s40629-017-0027-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617877PMC
May 2017
12 Reads

Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure: S2K Guideline of the German Society of Hygiene, Environmental Medicine and Preventive Medicine (GHUP) in collaboration with the German Association of Allergists (AeDA), the German Society of Dermatology (DDG), the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Occupational and Environmental Medicine (DGAUM), the German Society for Hospital Hygiene (DGKH), the German Society for Pneumology and Respiratory Medicine (DGP), the German Mycological Society (DMykG), the Society for Pediatric Allergology and Environmental Medicine (GPA), the German Federal Association of Pediatric Pneumology (BAPP), and the Austrian Society for Medical Mycology (ÖGMM).

Allergo J Int 2017 28;26(5):168-193. Epub 2017 Feb 28.

Department of Infection Control and Environmental Hygiene, Cologne Health Authority, Neumarkt 15-21, 50667 Cologne, Germany.

This article is an abridged version of the AWMF mould guideline "Medical clinical diagnostics of indoor mould exposure" presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. Apart from allergic bronchopulmonary aspergillosis (ABPA) and mould-caused mycoses, only sufficient evidence for an association between moisture/mould damage and the following health effects has been established: allergic respiratory disease, asthma (manifestation, progression and exacerbation), allergic rhinitis, hypersensitivity pneumonitis (extrinsic allergic alveolitis), and increased likelihood of respiratory infections/bronchitis. Read More

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http://dx.doi.org/10.1007/s40629-017-0013-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533814PMC
February 2017
50 Reads

Diagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnostics.

Allergo J Int 2017 11;26(3):93-105. Epub 2017 Apr 11.

Department of Dermatology and Venerology, Medical Center - University of Freiburg, Hauptstraße 7, 79104 Freiburg, Germany.

Background: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom.

Methods: Systematic literature research and review of current concepts of diagnostic testing in Hymenoptera venom allergy. Read More

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http://dx.doi.org/10.1007/s40629-017-0014-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406443PMC
April 2017
29 Reads

German guideline for the management of adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Association of Allergologists (AeDA), and the Swiss Society for Allergology and Immunology (SGAI).

Allergo J Int 2017 27;26(2):72-79. Epub 2017 Feb 27.

Department of Dermatology, Venereology, and Allergology Charité University Hospital, Charité Mitte Campus, Charitéplatz 1, 10117 Berlin, Germany.

Adverse food reactions are far more often perceived than objectively verified. In our scientific knowledge on non-allergic adverse reactions including the so called histamine intolerance, there are large deficits. Due to the fact that this disorder is increasingly discussed in the media and the internet, more and more people suspect it to be the trigger of their symptoms. Read More

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http://link.springer.com/10.1007/s40629-017-0011-5
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http://dx.doi.org/10.1007/s40629-017-0011-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346110PMC
February 2017
22 Reads

Six years of INSTAND e. V. sIgE proficiency testing: An evaluation of in vitro allergy diagnostics.

Allergo J Int 2017 18;26(2):43-52. Epub 2017 Jan 18.

Center of Life Sciences, AG IBAS, Hochschule Anhalt, Stenzfelder Allee 28, 06406 Bernburg (Saale), Germany.

Background: Even though allergies are an important health issue, wide manufacturer-dependent differences in the detected amounts of allergen-specific IgE (sIgE) have repeatedly been found. These discrepancies hinder diagnostics and research into clinically significant cutoff points for life-threatening symptoms.

Methods: To evaluate whether the reported differences have led to changes in diagnostic testing, we analyzed data from six years of round robin testing (RRT, also known as proficiency testing) at the Gesellschaft zur Förderung der Qualitätssicherung in medizinischen Laboratorien e. Read More

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http://dx.doi.org/10.1007/s40629-016-0005-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346112PMC
January 2017

Allergens and molecular diagnostics of shellfish allergy: Part 22 of the Series Molecular Allergology.

Allergo J Int 2016 2;25(7):210-218. Epub 2016 Nov 2.

Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, Queensland Australia ; Centre for Biodiscovery and Molecular Development of Therapeutics, James Cook University, Townsville, Queensland Australia ; College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland Australia.

Shellfish belongs to "The Big 8" food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Read More

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http://dx.doi.org/10.1007/s40629-016-0124-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306157PMC
November 2016

Allergy and school: nothing to be sneezed at!: A primary school project in Bielefeld, Germany, on epidemiology and health promotion in allergic diseases.

Allergo J Int 2016 2;25(7):201-209. Epub 2016 Nov 2.

Pediatric Allergology/Pneumology, Children´s Center Bethel, Evangelical Hospital, Bielefeld, Germany.

Background: Allergic diseases account for the largest proportion of chronic diseases in childhood and adolescence and place a significant burden on everyday family, social, and in particular school life. Without appropriate education, affected individuals often have little of the knowledge required to understand and deal safely with their allergic disease, and their social environment (school) generally offers insufficient information. An interdisciplinary project involving the Bielefeld Community Foundation ("Bielefelder Bürgerstiftung"), the Children's Center Bethel, and the local school authority investigated the current knowledge, possibilities for increasing that knowledge, as well as pupils' and teachers' perception of the problems experienced by fellow pupils, while at the same time collecting current prevalence figures on allergic diseases among primary school children. Read More

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http://dx.doi.org/10.1007/s40629-016-0131-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306160PMC
November 2016
6 Reads

Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care: Position Paper of the German Society of Allergology (AeDA) and the German Society of Allergy and Clinical Immunology (DGAKI), ENT Section, in collaboration with the working group on Clinical Immunology, Allergology and Environmental Medicine of the German Society of Otorhinolaryngology, Head and Neck Surgery (DGHNOKHC).

Allergo J Int 2017 19;26(1):16-24. Epub 2017 Jan 19.

Center for Rhinology and Allergology, An den Quellen 10, 65183 Wiesbaden, Germany.

Backround: Visual analogue scales (VAS) are psychometric measuring instruments designed to document the characteristics of disease-related symptom severity in individual patients and use this to achieve a rapid (statistically measurable and reproducible) classification of symptom severity and disease control. VAS can also be used in routine patient history taking and to monitor the course of a chronic disease such as allergic rhinitis (AR). More specifically, the VAS has been used to assess effectiveness of AR therapy in real life, both in intermittent and persistent disease. Read More

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http://link.springer.com/10.1007/s40629-016-0006-7
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http://dx.doi.org/10.1007/s40629-016-0006-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288410PMC
January 2017
12 Reads

Cost-effectiveness of grass pollen SCIT compared with SLIT and symptomatic treatment.

Allergo J Int 2017 21;26(1):7-15. Epub 2016 Nov 21.

Institute for Social Medicine, Epidemiology, and Health Economics, Charité - Universitätsmedizin Berlin, Luisenstraße 57, 10117 Berlin, Germany.

Background: Whereas specific immunotherapy (SIT) has already been shown to be cost-effective in the treatment of allergic rhinitis compared with symptomatic treatment, only a small number of investigations have compared sublingual (SLIT) and subcutaneous (SCIT) immunotherapeutic approaches. This analysis discusses the cost-effectiveness of SCIT compared with SLIT and a symptomatic treatment modality. At the same time, particular attention is paid to preparation-specific characteristics. Read More

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http://link.springer.com/10.1007/s40629-016-0002-y
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http://dx.doi.org/10.1007/s40629-016-0002-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288417PMC
November 2016
4 Reads

A novel experimental technology for testing efficacy of air purifiers on pollen reduction.

Allergo J Int 2017 16;26(1):1-6. Epub 2016 Nov 16.

Allergy-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Background: Allergenic pollen exposure is mostly seen as an outdoor phenomenon but studies have shown an indoor exposure: different pollen species including birch and grass pollen in houses, schools, and shops are leading to long-lasting symptoms even after the pollen season because pollen settle on surfaces and re-enter the indoor air depending on ventilation. To reduce indoor pollen load, windows need to be closed and devices should be used: as pure wiping and cleaning of surfaces is mostly not sufficient, air cleaners may be helpful in reducing pollen counts in indoor environment.

Objective: The efficacy of an air cleaner is usually described by the filtration rate of standard dust particle sizes which is not necessarily related to clinical efficacy. Read More

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http://dx.doi.org/10.1007/s40629-016-0001-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288418PMC
November 2016
34 Reads

Microbiota, regulatory T cell subsets, and allergic disorders.

Authors:
Caspar Ohnmacht

Allergo J Int 2016;25(5):114-123. Epub 2016 Aug 4.

Institute for Allergy Research Center of Allergy & Environment (ZAUM), Technische Universität München & Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1007/s40629-016-0118-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016534PMC

Coping with cross-reactive carbohydrate determinants in allergy diagnosis.

Allergo J Int 2016;25(4):98-105. Epub 2016 Jun 25.

Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, 1190 Vienna, Austria.

A relevant proportion of allergy diagnosis is accomplished by in vitro determination of specific immunglobulin E (sIgE) to extracts from suspected allergens. Such extracts inevitably contain glycoproteins, which may react with patients' IgE. In the case of plant and insect allergens, the relevant epitope structure is an α-1,3-fucose on the Asn-linked sugar residue of so-called N-glycans. Read More

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http://dx.doi.org/10.1007/s40629-016-0115-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016538PMC

The red meat allergy syndrome in Sweden.

Allergo J Int 2016;25(2):49-54. Epub 2016 Mar 23.

Department of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden ; Immunology and Allergy Unit, Department of Medicine, Solna Karolinska Institutet, Karolinska University Hospital Solna L2:04, SE-171 76 Stockholm, Sweden.

In the last decade, a novel type of food allergy presenting with severe allergic reactions several hours after consumption of red meat has been recognized. The allergic responses are due to IgE antibodies directed against the carbohydrate epitope galactose-α-1,3-galactose (α-Gal) found in mammalian meat. This review presents the red meat allergy syndrome in Sweden, discusses the features of the immune response to carbohydrates, and highlights the presence of heat stable α-Gal-containing proteins in meat. Read More

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http://dx.doi.org/10.1007/s40629-016-0098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016537PMC
March 2016
17 Reads

Update on the bird-egg syndrome and genuine poultry meat allergy.

Allergo J Int 2016;25:68-75. Epub 2016 May 2.

Molecular Biotechnology Section, University of Applied Sciences, Campus Vienna Biocenter, Vienna, Austria.

Allergy to poultry meat is rare and affects both children and adults. The prevalence of poultry meat allergy is unknown, but presumably is similar to that of red meat allergy. There is no close relationship between allergy to poultry meat and allergy to red meat. Read More

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http://dx.doi.org/10.1007/s40629-016-0108-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861744PMC
May 2016
20 Reads

S2k guideline on diagnosis and treatment of atopic dermatitis - short version.

Allergo J Int 2016;25:82-95. Epub 2016 May 2.

Allergie-Centrum-Charité, Klinik für Dermatologie, Venerologie und Allergologie, Charité - UniversitÄtsmedizin, Berlin, Deutschland.

Atopic dermatitis (AD) represents a pruritic, non-contagious, chronic or chronically relapsing, inflammatory skin disease. The course of the disease may be complicated by bacterial or viral superinfections. The first manifestation of the disease and further flare-ups are due to genetic predisposition and also to a variety of further trigger factors. Read More

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http://dx.doi.org/10.1007/s40629-016-0110-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861742PMC
May 2016
18 Reads

Clinical spectrum of α-Gal syndrome: from immediate-type to delayed immediate-type reactions to mammalian innards and meat.

Allergo J Int 2016;25:55-62. Epub 2016 Mar 23.

Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany.

The term α-Gal syndrome describes a novel IgE-mediated immediate-type allergy to the disaccharide galactose-α-1,3-galactose (α-Gal). Its classification as a syndrome is proposed on the basis of its clinical relevance in three different fields of allergy: food, drugs, and tick bites. The main focus of the present article is on α-Gal as an eliciting allergen in food allergy. Read More

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http://dx.doi.org/10.1007/s40629-016-0099-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861743PMC
March 2016
13 Reads

Evidence vs. efficacy in allergen-specific immunotherapy: Considerations using the example of tradable products in Germany.

Allergo J Int 2016;25:38-43. Epub 2016 Mar 23.

Ruhr Allergy Center, Ruhr University Bochum, Germany ; Bethel Pediatric Center, Bielefeld, Germany.

The recently published S2k-guideline on (allergen-) specific immunotherapy (AIT) provides an excellent overview of the evidence on allergen preparations available for AIT in Germany based on the published efficacy studies. Publications based on the guideline are currently being used by the German associations of statutory health insurance physicians and German health insurance funds to open a discussion on the reimbursement status of allergen preparations. In our view, calling the reimbursement status of perscribable and tradable AIT preparations into question on the basis of an assessment of the current body of evidence in the guideline is to be rigidly opposed. Read More

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http://dx.doi.org/10.1007/s40629-016-0096-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861740PMC
March 2016
8 Reads

Novel strategies for the treatment of asthma.

Allergo J Int 2016;25:11-17. Epub 2016 Feb 11.

Department of Pneumology and Critcal Care Medicine, University of Rostock, Rostock, Germany.

Novel treatment strategies are currently emerging for patients with inadequately controlled asthma despite good adherence and trigger avoidance. These strategies serve primarily to reduce or completely avoid long-term oral corticosteroid therapy. A number of these options have already been implemented in practice or will soon be authorized for the treatment of asthma, while others still need to prove their clinical practicability, safety and efficacy. Read More

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http://dx.doi.org/10.1007/s40629-016-0093-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792349PMC
February 2016
7 Reads

Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute.

Allergo J Int 2016;25:6-10. Epub 2016 Feb 11.

Specialist Field 24: Health Reporting, Head Office of the Environmental Medicine Commission, Robert Koch Institute, PO Box 650261, 13302 Berlin, Germany.

The lifetime prevalence of allergic diseases in adults in Germany [self-reported doctor diagnosed allergic diseases, Study on Adult Health in Germany (Studie zur Gesundheit Erwachsener in Deutschland, DEGS1, 2008-2011) of the Robert Koch Institute] is 8.6 % for asthma, 14.8 % for hay fever, 3. Read More

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http://dx.doi.org/10.1007/s40629-016-0092-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792334PMC
February 2016
5 Reads

Comparison of molecular and extract-based allergy diagnostics with multiplex and singleplex analysis.

Allergo J Int 2015;24:46-53. Epub 2015 Mar 14.

University Freiburg Medical Center, Department of Exercise Medicine and Sport, University of Freiburg, Freiburg, Germany ; Department of Pneumology, University of Freiburg, Freiburg, Germany ; Department of Pneumology, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany.

Background: ImmunoCAP ISAC 112, is a commercially available molecular allergy IgE multiplex test. Data on the comparison of this rather novel test with extract-based as well as molecular ImmunoCAP singleplex IgE tests is missing.

Objective: To perform a comparison between the ISAC multiplex IgE assay and the ImmunoCAP singleplex test results. Read More

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http://dx.doi.org/10.1007/s40629-015-0046-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686215PMC
March 2015
63 Reads

Acid suppression therapy and allergic reactions.

Authors:
Eva Untersmayr

Allergo J Int 2015 Dec;24(8):303-311

Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

The development of pharmaceutical agents such as sucralfate, histamine 2 (H2) receptor blockers and proton pump inhibitors (PPIs) reducing gastric acidity has been a mile stone for treatment of dyspeptic disorders. However, due to current prescription habits resulting in overuse of these potent drugs as well as over-the-counter (OTC) availability associated with self-medication, substantial health concern is related to the mechanisms of drug action as well as known side effects influencing gastrointestinal physiology. More than a decade ago the first study appeared reporting an association between anti-ulcer drug intake and food allergy development. Read More

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http://link.springer.com/10.1007/s40629-015-0085-x
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http://dx.doi.org/10.1007/s40629-015-0085-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464390PMC
December 2015
10 Reads

Guideline for the diagnosis of drug hypersensitivity reactions: S2K-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) and the German Dermatological Society (DDG) in collaboration with the Association of German Allergologists (AeDA), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Swiss Society for Allergy and Immunology (SGAI), the Austrian Society for Allergology and Immunology (ÖGAI), the German Academy of Allergology and Environmental Medicine (DAAU), the German Center for Documentation of Severe Skin Reactions and the German Federal Institute for Drugs and Medical Products (BfArM).

Allergo J Int 2015;24(3):94-105

Department of Dermatology and Allergology, RTWH Aachen, Aachen, Germany.

Drug hypersensitivity reactions are unpredictable adverse drug reactions. They manifest either within 1-6 h following drug intake (immediate reactions) with mild to life-threatening symptoms of anaphylaxis, or several hours to days later (delayed reactions), primarily as exanthematous eruptions. It is not always possible to detect involvement of the immune system (allergy). Read More

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http://www.awmf.org/fileadmin/user_upload/Leitlinien/061_D_G
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http://link.springer.com/10.1007/s40629-015-0052-6
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http://dx.doi.org/10.1007/s40629-015-0052-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479479PMC
January 2015
32 Reads

Authorised allergen products for intracutaneous testing may no longer be available in Germany: Allergy textbooks have to be re-written.

Allergo J Int 2015;24(3):84-93. Epub 2015 May 9.

Group Practice for Dermatology, Immunology and Allergology, Erfurt, Germany ; Medical Association of German Allergologists (Ärzteverband Deutscher Allergologen, AeDA), Dreieich, Germany.

Background: Beside the skin prick test, the intracutaneous test represents the most important skin test method for detecting type-1 allergies. With the incorporation of European directives into national law, test allergens used for allergy diagnosis are deemed medicinal products within the meaning of the German Medicinal Products Act (Arzneimittelgesetz) and therefore require marketing authorisation for distribution in Germany. The high costs of acquiring and maintaining these authorisations have lead to no new finished intracutaneous test products being authorized in Germany for more than 20 years. Read More

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http://link.springer.com/10.1007/s40629-015-0051-7
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http://dx.doi.org/10.1007/s40629-015-0051-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479459PMC
May 2015
7 Reads

Mammalian meat allergy: a diagnostic challenge.

Allergo J Int 2015;24(3):81-83. Epub 2015 May 9.

University dermatology clinic, Tübingen, Germany.

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http://dx.doi.org/10.1007/s40629-015-0050-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479427PMC
May 2015
2 Reads

Mites and other indoor allergens - from exposure to sensitization and treatment.

Allergo J Int 2015;24(3):68-80. Epub 2015 May 9.

Centre for Rhinology and Allergology, Wiesbaden, Germany.

House dust mites, cats and dogs are amongst the most frequent sources of indoor allergens in Europe. The fact that the allergens of house dust mites cause allergic disease through inhalation of house dust was discovered in 1964. The diagnosis of mite allergy is regularly complicated by its often nonspecific symptoms, which frequently develop insidiously and by no means always include attacks of paroxysmal sneezing and itching. Read More

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http://dx.doi.org/10.1007/s40629-015-0049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479455PMC
May 2015
5 Reads

Hypersensitivity reactions to modern antiplatelet and anticoagulant drugs.

Allergo J Int 2015;24(2):58-66. Epub 2015 Mar 14.

Allergy Unit, Department of Dermatology, University Hospital, Basel, Switzerland ; Allergy Unit Department of Dermatology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

Anticoagulation and antiplatelet drugs are among the most commonly used medical drugs. In addition to the long-established heparins, hirudins, coumarins and antiplatelet drugs such as acetylsalicylic acid, numerous novel and predominantly synthetic pharmacologic agents have come onto the market in recent years. These new agents act at various sites in coagulation and have significantly broadened treatment options. Read More

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http://dx.doi.org/10.1007/s40629-015-0048-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479548PMC
March 2015
1 Read

Occupational allergy to β-lactam antibiotics.

Allergo J Int 2015;24(2):54-57. Epub 2015 Mar 14.

Clinic for Dermatology, Venereology and Allergology University Hospital, Georg-August University, Robert-Koch-Straße 40, 37075 Göttingen, Germany.

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http://link.springer.com/10.1007/s40629-015-0047-3
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http://dx.doi.org/10.1007/s40629-015-0047-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479519PMC
March 2015
6 Reads

Reply to the correspondence to the "Guideline for acute therapy and management of anaphylaxis".

Authors:
Johannes Ring

Allergo J Int 2015;24(1):45

Klinikum rechts der Isar Technische Universität Munich, Biedersteiner Straße 29, 80802 Munich, Germany.

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http://dx.doi.org/10.1007/s40629-015-0040-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479454PMC
January 2015
2 Reads

Correspondence to the "Guideline for acute therapy and management of anaphylaxis".

Allergo J Int 2015;24(1):44

Infectopharm, Von-Humbold-Straße 1, 64646 Heppenheim, Germany.

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http://dx.doi.org/10.1007/s40629-015-0036-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479430PMC
January 2015

Guideline for authors: Allergo Journal International.

Authors:
Marion Weber

Allergo J Int 2015;24(1):23

Springer Medizin, Urban & Vogel GmbH, Aschauer Straße 30, 81549 München, Germany.

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http://dx.doi.org/10.1007/s40629-015-0041-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479450PMC
January 2015
1 Read

Autoallergy in atopic dermatitis.

Allergo J Int 2015;24(1):16-22. Epub 2015 Feb 9.

Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany ; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

The term autoallergy denotes autoimmunity accompanying an atopic disease, with antigen-specific IgE as a hallmark. This phenomenon is discussed to contribute to a chronification of the disease and to shape the immune response in chronic atopic dermatitis (AD). In this review, we highlight recent insights into the autoallergic inflammation in AD. Read More

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http://dx.doi.org/10.1007/s40629-015-0037-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479480PMC
February 2015

Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis.

Allergo J Int 2015;24(1):8-15. Epub 2015 Feb 9.

Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, Marburg, Germany.

The activation of naive CD4+ and CD8+ T cells in response to antigen and their subsequent proliferation and differentiation into effectors are important features of a cell-mediated immune response. CD4+ T cells (also known as T helper cells, Th) differentiate into several subpopulations including Th1, Th2, Th9, Th17, Tfh and Treg cells, characterized by specific cytokine profiles and effector functions. However, recent evidence indicates that CD8+ T cells (termed cytotoxic T lymphocytes, CTLs or Tc cells) can differentiate into subpopulations with similar characteristics denoted as Tc2, Tc9, Tc17 and CD8+ Treg cells in addition to CTLs. Read More

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http://dx.doi.org/10.1007/s40629-015-0038-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479451PMC
February 2015

Th22 cells in allergic disease.

Allergo J Int 2015;24(1):1-7. Epub 2015 Feb 9.

AUM - Center for Allergy and Environment, Technische Universität und Helmholtz Center Munich, Munich, Germany.

During the last decade, the field of T cell immunology started to confuse the scientific community. More and more subtypes of T helper cells and their counterparts in the innate immune system are described. We are just at the beginning to understand which specific function the distinct subtypes fulfill. Read More

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http://dx.doi.org/10.1007/s40629-015-0039-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479457PMC
February 2015

(ragweed) in Germany - current presence, allergological relevance and containment procedures.

Allergo J Int 2015;24:108-120. Epub 2015 Jul 11.

Foundation German Pollen Information Service, Berlin, Germany.

(ragweed) is a neophyte in Europe and Germany, which originated from the United States of America. In the USA the rate of sensitization against ragweed equals that of grass pollen, and without containment the rate of allergic sensitizations against ragweed pollen will clearly increase. Currently, the most frequent sensitizations in Germany are against grass pollen, followed by sensitizations against house dust mite and birch pollen. Read More

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http://dx.doi.org/10.1007/s40629-015-0060-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861741PMC
July 2015
11 Reads

Molecular allergy diagnostics using multiplex assays: methodological and practical considerations for use in research and clinical routine: Part 21 of the Series Molecular Allergology.

Allergo J Int 2015;24:320-332. Epub 2015 Dec 17.

Westend Allergy and Asthma Center, Hanf, Ackermann-Simon, and Kleine-Tebbe Specialist Allergy Practice, Berlin, Germany.

The availability of single allergens and their use in microarray technology enables the simultaneous determination of specific IgE (sIgE) to a multitude of different allergens (> 100) in a multiplex procedure requiring only minute amounts of serum. This allows extensive individual sensitization profiles to be determined from a single analysis. Combined with a patient's medical history, these profiles simplify identification of cross-reactivity; permit a more accurate estimation of the risk of severe reactions; and enable the indication for specific immunotherapy to be more precisely established, particularly in cases of polysensitization. Read More

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http://dx.doi.org/10.1007/s40629-015-0087-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792369PMC
December 2015
16 Reads

13-year overview of serious adverse drug reactions following subcutaneous specific immunotherapy with a chemically modified allergen preparation.

Allergo J Int 2015;24:294-302. Epub 2015 Dec 17.

HAL Allergy B.V., Leiden, The Netherlands.

Background: The Paul-Ehrlich-Institut (PEI) published an analysis of reports of adverse drug reactions (ADRs) in 2001 with test and therapy allergens from the period from 1991 to 2000. Possible risk factors were evaluated for the ADR reports classified as "serious". During the analyzed period, modified semi-depot preparations (allergoids) induced between 0. Read More

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http://dx.doi.org/10.1007/s40629-015-0084-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792348PMC
December 2015