6,804 results match your criteria Allergic and Environmental Asthma


High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice.

Respir Res 2020 Jul 2;21(1):168. Epub 2020 Jul 2.

Department of Experimental Pneumology and Allergology, Faculty of Medicine, Saarland University, Homburg, Germany.

Background: Titanium dioxide nanoparticles (TiO NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO powder are more susceptible to the risks of developing respiratory diseases. Accordingly, this issue has increasingly attracted the researchers' interest in understanding the consequences of TiO NPs exposure. Read More

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http://dx.doi.org/10.1186/s12931-020-01386-0DOI Listing

House dust microbiota in relation to adult asthma and atopy in a U.S. farming population.

J Allergy Clin Immunol 2020 Jun 29. Epub 2020 Jun 29.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS), Research Triangle Park (RTP), North Carolina (NC), USA. Electronic address:

Background: Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear.

Objective: To examine associations of house dust microbiota with adult asthma, atopy, and hay fever.

Methods: Vacuumed bedroom dust samples from the homes of 879 participants (average age 62) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.013DOI Listing

Association between maternal age at delivery and allergic rhinitis in schoolchildren: A population-based study.

World Allergy Organ J 2020 Jun 23;13(6):100127. Epub 2020 Jun 23.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: Some studies have shown associations of maternal age at delivery with asthma and food allergy in offspring. However, the relationship between maternal age at delivery and allergic rhinitis is largely unclear. This study aimed to investigate the association between maternal age at delivery and allergic rhinitis in a population sample of Asian children, and to explore potential effect modifiers. Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322179PMC

Environmental and Endogenous Acids Can Trigger Allergic-Type Airway Reactions.

Int J Environ Res Public Health 2020 Jun 29;17(13). Epub 2020 Jun 29.

Elsa Nervo, Società Chimica Italiana, 00198 Rome, Italy.

Inflammatory allergic and nonallergic respiratory disorders are spreading worldwide and often coexist. The root cause is not clear. This review demonstrates that, from a biochemical point of view, it is ascribable to protons (H) released into cells by exogenous and endogenous acids. Read More

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http://dx.doi.org/10.3390/ijerph17134688DOI Listing

Allergic Rhinitis and Its Epidemiological Distribution in Syria: A High Prevalence and Additional Risks in War Time.

Biomed Res Int 2020 23;2020:7212037. Epub 2020 May 23.

Faculty of medicine, Damascus University, Damascus, Syria.

Background: Allergic rhinitis (AR) is a global disease that affects a huge proportion of people around the world especially in the Middle East, where multiple allergy-promoting factors can be found. Although AR is not fatal, it severely affects the quality of life. However, it is usually overlooked in developing countries due to resource scarcity. Read More

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http://dx.doi.org/10.1155/2020/7212037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273446PMC

Circadian Regulation of the Biology of Allergic Disease: Clock Disruption Can Promote Allergy.

Authors:
Atsuhito Nakao

Front Immunol 2020 12;11:1237. Epub 2020 Jun 12.

Department of Immunology, Faculty of Medicine, University of Yamanashi, Kofu, Japan.

Allergic diseases such as allergic rhinitis, asthma, atopic dermatitis, and food allergy are characterized by epithelial barrier dysfunction and deregulated immune responses. Components of the circadian clock interact with critical elements of epithelial barrier function and immune responses, and regulate the biological processes on a 24-h cycle at steady state. This may represent an anticipatory defense response to day-night fluctuation of attack by noxious stimuli such as pathogens in the environment. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304491PMC

The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens.

Allergy 2020 Jun 26. Epub 2020 Jun 26.

Research director at the French NIH (INSERM) and responsible of the EPAR Department, IPLESP, INSERM and Sorbonne University, Paris, France.

The impact of climate change on the environment, biosphere and biodiversity has become more evident in the recent years. Human activities have increased atmospheric concentrations of carbon dioxide (CO ) and other greenhouse gases. Change in climate and the correlated global warming affects the quantity, intensity and frequency of precipitation type as well as the frequency of extreme events such as heat waves, droughts, thunderstorms, floods and hurricanes. Read More

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http://dx.doi.org/10.1111/all.14476DOI Listing
June 2020
6.028 Impact Factor

ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020).

Authors:
Jean Bousquet Marek Jutel Cezmi A Akdis Ludger Klimek Oliver Pfaar Kari C Nadeau Thomas Eiwegger Anna Bedbrook Ignacio J Ansotegui Josep M Anto Claus Bachert Eric D Bateman Kazi S Bennoor Emilia Camelia Berghea Karl-Christian Bergmann Hubert Blain Mateo Bonini Sinthia Bosnic-Anticevich Louis-Philippe Boulet Luisa Brussino Roland Buhl Paulo Camargos G Walter Canonica Victoria Cardona Thomas Casale Sharon Chinthrajah Mübeccel Akdis Tomas Chivato George Christoff Alvaro A Cruz Wienczyslawa Czarlewski Stefano Del Giacco Hui Du Yehia El-Gamal Wytske J Fokkens Joao A Fonseca Yadong Gao Mina Gaga Bilun Gemicioglu Maia Gotua Tari Haahtela David Halpin Eckard Hamelmann Karin Hoffmann-Sommergruber Marc Humbert Nataliya Ilina Juan-Carlos Ivancevich Guy Joos Musa Khaitov Bruce Kirenga Edward F Knol Fanny W Ko Seppo Koskinen Marek L Kowalski Helga Kraxner Dmitri Kudlay Piotr Kuna Maciej Kupczyk Violeta Kvedariene Amir H Abdul Latiff Lan T Le Michael Levin Desiree Larenas-Linnemann Renaud Louis Mohammad R Masjedi Erik Melén Florin Mihaltan Branislava Milenkovic Yousser Mohammad Mario Morais-Almeida Joaquim Mullol Leyla Namazova Hugo Neffen Elisabete Nunes Paul O'Byrne Robyn O'Hehir Liam O'Mahony Ken Ohta Yoshitaka Okamoto Gabrielle L Onorato Petr Panzner Nikos G Papadopoulos Gianni Passalacqua Vincenzo Patella Ruby Pawankar Nhân Pham-Thi Bernard Pigearias Todor A Popov Francesca Puggioni Frederico S Regateiro Giovanni Rolla Menachem Rottem Boleslaw Samolinski Joaquin Sastre Jurgen Schwarze Aziz Sheikh Nicola Scichilone Manuel Soto-Quiros Milan Sova Stefania Nicola Rafael Stelmach Charlotte Suppli-Ulrik Luis Taborda-Barata Teresa To Peter-Valentin Tomazic Sanna Toppila-Salmi Ioanna Tsiligianni Omar Usmani Arunas Valiulis Maria Teresa Ventura Giovanni Viegi Theodor Vontetsianos De Yun Wang Sian Williams Gary Wk Wong Arzu Yorgancioglu Mario Zernotti Mihaela Zidarn Torsten Zuberbier Ioana Agache

Allergy 2020 Jun 26. Epub 2020 Jun 26.

Transylvania University Brasov, Brasov, Romania.

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http://dx.doi.org/10.1111/all.14471DOI Listing

Prenatal and postnatal exposures to ambient air pollutants associated with allergies and airway diseases in childhood: A retrospective observational study.

Environ Int 2020 Sep 22;142:105853. Epub 2020 Jun 22.

Department of Building Environment and Energy Engineering, School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China.

It's inconsistent about associations of early exposures to outdoor air pollutants with allergies and airway diseases in childhood. Here, we investigated associations of prenatal and postnatal exposures to outdoor nitrogen dioxide (NO), sulphur dioxide (SO), and PM (particulate matter with an aerodynamic diameter ≤ 10 μm) with asthma, wheeze, hay fever, rhinitis, pneumonia, and eczema in childhood. We surveyed 3,177 preschoolers who never change residences since birth in Shanghai, China. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105853DOI Listing
September 2020

Immunology of COVID-19: mechanisms, clinical outcome, diagnostics and perspectives - a report of the European Academy of Allergy and Clinical Immunology (EAACI).

Allergy 2020 Jun 25. Epub 2020 Jun 25.

Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS-CoV-2-induced Coronavirus disease-19 (COVID-19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. Read More

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http://dx.doi.org/10.1111/all.14462DOI Listing

The Role of Fucoidans Isolated from the Sporophylls of against Particulate-Matter-Induced Allergic Airway Inflammation: Evidence of the Attenuation of Oxidative Stress and Inflammatory Responses.

Molecules 2020 Jun 22;25(12). Epub 2020 Jun 22.

Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea.

Ambient particulate matter (PM) is a critical environment pollutant that promotes the onset and aggravation of respiratory diseases such as asthma through airway inflammation and hypersecretion of mucus. In this study, we aimed to identify the effects of fucoidans isolated from sporophylls of on asthma symptoms such as the inflammatory response and mucus secretion using a mouse model. Balb/c mice, intraperitoneally sensitized with ovalbumin (OVA, 10 μg) dissolved in 200 µL saline and 2 mg Al(OH), were exposed to PM (5 mg/m) for 7 consecutive days. Read More

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http://dx.doi.org/10.3390/molecules25122869DOI Listing

Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases-POLLAR symposium under the auspices of Finland's Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing.

Clin Transl Allergy 2020 19;10:24. Epub 2020 Jun 19.

KYomed INNOV, Montpellier, France.

In December 2019, a conference entitled "Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health" was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the Finnish Environment Institute and the European Commission, under the auspices of Finland's Presidency of the EU. As a side event, a symposium organized as the final POLLAR (Impact of air POLLution on Asthma and Rhinitis) meeting explored the digital transformation of health and care to sustain planetary health in airway diseases. Read More

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http://dx.doi.org/10.1186/s13601-020-00321-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304084PMC

Airborne particulate matter from goat farm increases acute allergic airway responses in mice.

Inhal Toxicol 2020 May 22;32(6):265-277. Epub 2020 Jun 22.

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Inhalation exposure to biological particulate matter (BioPM) from livestock farms may provoke exacerbations in subjects suffering from allergy and asthma. The aim of this study was to use a murine model of allergic asthma to determine the effect of BioPM derived from goat farm on airway allergic responses. Fine (<2. Read More

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http://dx.doi.org/10.1080/08958378.2020.1781986DOI Listing

Lung function and exercise capacity in prematurely born young people.

Pediatr Pulmonol 2020 Jun 22. Epub 2020 Jun 22.

Department of Women and Children's Health, Faculty of Life Sciences & Medicine, School of Life Course Sciences, King's College London, London, UK.

Objectives: To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity.

Working Hypothesis: In the current era, lung function abnormalities would not be associated with exercise intolerance STUDY DESIGN: Follow-up of young people from the United Kingdom Oscillation study (UKOS).

Patient-subject Selection: One hundred twenty-six young people of 797 recruited to UKOS, born at a mean gestational age of 27 weeks were assessed at a mean age of 17 years. Read More

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http://dx.doi.org/10.1002/ppul.24918DOI Listing

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Society of Allergology (AeDA), German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Austrian Society for Allergology and Immunology (ÖGAI), and the Paul-Ehrlich Society for Chemotherapy (PEG).

Allergol Select 2020 28;4:11-43. Epub 2020 May 28.

Department of Dermatology and Allergology am Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories clearly exceeds the number of confirmed cases. Read More

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http://dx.doi.org/10.5414/ALX02104EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304290PMC

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma.

Expert Opin Ther Targets 2020 Jun 27:1-16. Epub 2020 Jun 27.

Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D , Gaithersburg, MD, USA.

Introduction: Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a central regulator of the immune response to inhaled environmental insults such as allergens, viruses and pollutants, initiating a cascade of downstream inflammation. There is compelling evidence that TSLP plays a major role in the pathology of asthma, and therapies that aim to block its activity are in development.

Areas Covered: We review studies conducted in humans and human cells , largely published in PubMed January 2010-October 2019, that investigated the innate and adaptive immune mechanisms of TSLP in asthma relevant to type 2-driven (eosinophilic/allergic) inflammation and non-type 2-driven (non-eosinophilic/non-allergic) inflammation, and the role of TSLP as a mediator between immune cells and structural cells in the airway. Read More

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http://dx.doi.org/10.1080/14728222.2020.1783242DOI Listing

Associations between household airborne culturable fungi and allergies and airway illnesses in childhood in Shanghai, China.

Environ Sci Pollut Res Int 2020 Jun 20. Epub 2020 Jun 20.

School of Environment and Architecture, University of Shanghai for Science and Technology, 516 Jungong Road, Yangpu District, Shanghai, People's Republic of China.

Associations of household airborne fungi with allergies in childhood were inconsistent in the epidemiologic studies. During 2013-2014, we conducted a case-control study (phase two), which was nested in a cross-sectional study (phase one) during 2011-2012 in Shanghai, China. We inspected indoor air quality of 454 residences for 5-10 years old children. Read More

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http://dx.doi.org/10.1007/s11356-020-09717-wDOI Listing

Tumor Suppressors-HTRA Proteases and Interleukin-12-in Pediatric Asthma and Allergic Rhinitis Patients.

Medicina (Kaunas) 2020 Jun 17;56(6). Epub 2020 Jun 17.

Department of General and Medical Biochemistry, University of Gdańsk, Wita Stwosza 59 80-308 Gdańsk, Poland.

: Allergy belongs to a group of mast cell-related disorders and is one of the most common diseases of childhood. It was shown that asthma and allergic rhinitis diminish the risk of various cancers, including colon cancer and acute lymphoblastic leukemia. On the other hand, asthma augments the risk of lung cancer and an increased risk of breast cancer in patients with allergy has been observed. Read More

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http://dx.doi.org/10.3390/medicina56060298DOI Listing

Efficacy of Transdermal Immunotherapy with Biodegradable Microneedle Patches in a Murine Asthma Model.

Clin Exp Allergy 2020 Jun 17. Epub 2020 Jun 17.

Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Background: House dust mite (HDM) is a well-known cause of asthma. Allergen specific immunotherapy (AIT) can only modify the natural course of the disease. Conventional routes of HDM AIT are subcutaneous or sublingual. Read More

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http://dx.doi.org/10.1111/cea.13688DOI Listing
June 2020
4.769 Impact Factor

Home environment allergen exposure scale in older adult cohort with asthma.

Can J Public Health 2020 Jun 16. Epub 2020 Jun 16.

University of Kansas School of Nursing, Kansas City, KS, USA.

Objectives: Home environmental exposures are a primary source of asthma exacerbation. There is a gap in decision support models that efficiently aggregate the home exposure assessment scores for focused and tailored interventions. Three development methods of a home environment allergen exposure scale for persons with asthma (weighted by dimension reduction, unweighted, precision biomarker-based) were compared, and racial disparity tested. Read More

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http://dx.doi.org/10.17269/s41997-020-00335-0DOI Listing

Role of the Microbiome in Allergic Disease Development.

Curr Allergy Asthma Rep 2020 Jun 16;20(9):44. Epub 2020 Jun 16.

Department of Pediatrics, Indiana School of Medicine, 705 Riley Hospital Drive, RI 2606, Indianapolis, IN, 46202, USA.

Purpose Of Review: Evidence suggests that the microbiome of the skin, gastrointestinal tract, and airway contribute to health and disease. As we learn more about the role that the microbiota plays in allergic disease development, we can develop therapeutics to alter this pathway.

Recent Findings: Epidemiologic studies reveal that an association exists between environmental exposures, which alter the microbiota, and developing atopic dermatitis, food allergy, and/or asthma. Read More

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http://dx.doi.org/10.1007/s11882-020-00944-2DOI Listing

The Honeybee Venom Major Allergen Api m 10 (Icarapin) and Its Role in Diagnostics and Treatment of Hymenoptera Venom Allergy.

Curr Allergy Asthma Rep 2020 Jun 16;20(9):48. Epub 2020 Jun 16.

Center of Allergy and Environment (ZAUM), Technical University of Munich, School of Medicine and Helmholtz Center Munich, German Research Center for Environmental Health, Member of the German Center of Lung Research (DZL), Munich, Germany.

Purpose Of Review: In Hymenoptera venom allergy, the research focus has moved from whole venoms to individual allergenic molecules. Api m 10 (icarapin) has been described as a major allergen of honeybee venom (HBV) with potentially high relevance for diagnostics and therapy of venom allergy. Here, we review recent studies on Api m 10 characteristics as well as its role in component-resolved diagnostics and potential implications for venom-specific immunotherapy (VIT). Read More

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http://dx.doi.org/10.1007/s11882-020-00943-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297703PMC

Role of Environmental Adjuvants in Asthma Development.

Authors:
Donald N Cook

Curr Allergy Asthma Rep 2020 Jun 16;20(9):42. Epub 2020 Jun 16.

Immunogenetics Group, Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Dr., Research Triangle Park, Durham, NC, 27709, USA.

Purpose Of Review: This review summarizes recent progress in our understanding how environmental adjuvants promote the development of asthma.

Recent Findings: Asthma is a heterogeneous set of lung pathologies with overlapping features. Human studies and animal models suggest that exposure to different environmental adjuvants activate distinct immune pathways, which in turn give rise to distinct forms, or endotypes, of allergic asthma. Read More

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http://dx.doi.org/10.1007/s11882-020-00935-3DOI Listing

Effect of pulmonary rehabilitation in an allergen safe outdoor environment on children and adolescents with mild to moderate persistent allergic asthma.

J Asthma 2020 Jun 30:1-7. Epub 2020 Jun 30.

Srebrnjak Children's Hospital, Zagreb, Croatia.

Environmental interactions are very complex in childhood asthma, and we hypothesized that even a short-term exposure to an allergy safe outdoor environment (AllSOE) combined with pulmonary rehabilitation program (PRP) could exert significant beneficial effects. Our aim was to test the effects of 2-week PRP provided in an AllSOE in children with mild to moderate asthma. 110 children (aged 7. Read More

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http://dx.doi.org/10.1080/02770903.2020.1784192DOI Listing

Immunomodulatory properties of Schistosoma mansoni proteins Sm200 and SmKI-1 in vitro and in a murine model of allergy to the mite Blomia tropicalis.

Mol Immunol 2020 Jun 13;124:91-99. Epub 2020 Jun 13.

Institute of Health Science - ICS, Federal University of Bahia, Salvador, Brazil. Electronic address:

The prevalence of allergic diseases in Brazil is one of the biggest in the world. Among these pathologies, we highlight asthma as one of the most importance. Asthma is characterized as a chronic inflammatory disease of airways, associated with hyperresponsiveness. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.05.011DOI Listing

Impact of air pollution on educational attainment for respiratory health treated students: A cross sectional data linkage study.

Health Place 2020 May 12;63:102355. Epub 2020 May 12.

Department of Public Health and Policy, University of Liverpool, Liverpool, UK. Electronic address:

Introduction: There is some evidence that exam results are worse when students are acutely exposed to air pollution. Studies investigating the association between air pollution and academic attainment have been constrained by small sample sizes.

Methods: Cross sectional educational attainment data (2009-2015) from students aged 15-16 years in Cardiff, Wales were linked to primary health care data, modelled air pollution and measured pollen data, and analysed using multilevel linear regression models. Read More

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http://dx.doi.org/10.1016/j.healthplace.2020.102355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214342PMC

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation.

J Vis Exp 2020 May 30(159). Epub 2020 May 30.

Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, University of Texas Health San Antonio;

Environmental allergens such as house dust mites (HDM) are often in complex forms containing both allergic proteins that drive aberrant type 2 responses and microbial substances that induce innate immune responses. These allergen-associated microbial components play an important role in regulating the development of type 2 inflammatory conditions such as allergic asthma. However, the underlying mechanisms remain largely undefined. Read More

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http://dx.doi.org/10.3791/61183DOI Listing

Food Allergy in At- Risk Adolescents with Asthma: A Key Area for Focus.

Ann Allergy Asthma Immunol 2020 Jun 10. Epub 2020 Jun 10.

Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester NY, United States.

Background: Asthma affects more than 6.2 million children in the United States and is a major source of chronic disease burden. Concurrent food allergy may be a risk factor for worse asthma outcomes. Read More

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http://dx.doi.org/10.1016/j.anai.2020.06.004DOI Listing

COVID-19 pandemic: Practical considerations on the organization of an allergy clinic - an EAACI/ARIA Position Paper.

Allergy 2020 Jun 12. Epub 2020 Jun 12.

Transylvania University, Brasov, Romania.

Background: The Coronavirus disease 2019 (COVID-19) has evolved as a pandemic infectious disease transmitted by the severe acute respiratory syndrome coronavirus (SARS-CoV-)2. Allergists and other health care providers (HCPs) in the field of allergies and associated airway diseases are in the front line, taking care of patients potentially infected with SARS-CoV-2. Hence, strategies and practices to minimize risks of infection for both HCPs and treated patients have to be developed and followed by allergy clinics. Read More

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http://dx.doi.org/10.1111/all.14453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323448PMC

Risk Factors Associated With Bronchiolitis in Puerto Rican Children.

Pediatr Emerg Care 2020 Jun 11. Epub 2020 Jun 11.

Department of Emergency Medicine, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.

Objective: The objective of this study was to identify frequency, severity, and risk factors associated with bronchiolitis in Puerto Rican children.

Methods: A cross-sectional was study performed at 4 emergency departments of Puerto Rico's metropolitan area, between June 2014 and May 2015. We included children younger than 24 months, with a clinical diagnosis of bronchiolitis, who were born and living in Puerto Rico at the time of recruitment. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002130DOI Listing

The home environment's influence on cytokine profiles and atopic disease in 6/7 year old children.

Ann Allergy Asthma Immunol 2020 Jun 8. Epub 2020 Jun 8.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada; Allergy Research Unit, Kingston Health Sciences Centre - Kingston General Hospital site, Kingston, ON, Canada; Department of Medicine, Queen's University, Kingston ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.06.002DOI Listing

Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Depts of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.

Rationale: Allergic diseases are an increasing public health concern and early life environment is critical to immune development. Maternal diet during pregnancy has been linked to offspring allergy risk. In turn, maternal diet is a potentially modifiable factor, which could be targeted as an allergy prevention strategy. Read More

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http://dx.doi.org/10.1111/pai.13303DOI Listing

probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model.

Gut Microbes 2020 Nov 10;11(6):1729-1744. Epub 2020 Jun 10.

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerp , Antwerp, Belgium.

Allergic asthma is a highly prevalent inflammatory disease of the lower airways, clinically characterized by airway hyperreactivity and deterioration of airway function. Immunomodulatory probiotic bacteria are increasingly being explored to prevent asthma development, alone or in combination with other treatments. In this study, wild-type and recombinant probiotic GR-1 were tested as preventive treatment of experimental allergic asthma in mice. Read More

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http://dx.doi.org/10.1080/19490976.2020.1766345DOI Listing
November 2020

Pediatric allergic diseases in the Indian subcontinent-Epidemiology, risk factors and current challenges.

Pediatr Allergy Immunol 2020 Jun 10. Epub 2020 Jun 10.

Department of Pulmonary Medicine, Christian Medical College, Tamil Nadu and Indian Chest Society, Vellore, India.

Introduction: India is low-middle-income country (LMIC) with a population of 1.3bn, comprising about 20% of the global population. While the high-income Western countries faced an "allergy epidemic" during the last three decades, there has been a gradual rise in prevalence of allergic diseases in India. Read More

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http://dx.doi.org/10.1111/pai.13306DOI Listing

ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice.

Authors:
Jean Bousquet Josep M Anto Claus Bachert Tari Haahtela Torsten Zuberbier Wienczyslawa Czarlewski Anna Bedbrook Sinthia Bosnic-Anticevich G Walter Canonica Victoria Cardona ElisioCosta Alvaro A Cruz Marina Erhola Wytske J Fokkens Joao A Fonseca Maddalena Illario Juan CarlosIvancevich Marek Jutel Ludger Klimek PiotrKuna Violeta Kvedariene Ltt Le Desiree Larenas-Linnemann Daniel Laune Olga M Lourenço Eric Melén Joaquim Mullol Marek Niedoszytko Mikaëla Odemyr Yoshitaka Okamoto Nikos G Papadopoulos Vincenzo Patella Oliver Pfaar Nhân Pham-Thi Christine Rolland Boleslaw Samolinski Aziz Sheikh Mikhail Sofiev Charlotte SuppliUlrik Ana Todo-Bom Peter V Tomazic Sanna Toppila-Salmi Ioanna Tsiligianni Arunas Valiulis Erkka Valovirta Maria-Teresa Ventura Samantha Walker Sian Williams Arzu Yorgancioglu Ioana Agache Cezmi A Akdis Rute Almeida Ignacio J Ansotegui Isabella Annesi-Maesano Sylvie Arnavielhe Xavier Basagaña Eric Bateman Annabelle Bédard Martin Bedolla-Barajas Sven Becker Kazi S Bennoor Samuel Benveniste Karl C Bergmann Michael Bewick Slawomir Bialek Nils Billo Carsten Bindslev-Jensen Leif Bjermer Hubert Blain Matteo Bonini Philippe Bonniaud Isabelle Bosse Jacques Bouchard Louis P Boulet Rodolphe Bourret Koen Boussery Fluvio Braido Vitalis Briedis Andrew Briggs Christopher E Brightling JanBrozek Guy Brusselle Luisa Brussino Roland Buhl Roland Buonaiuto Moises A Calderon Paolo Camargos Thierry Camuzat Luis Caraballo Ana Maria Carriazo Warner Carr Christine Cartier Thomas Casale Lorenzo Cecchi Alfonso M Cepeda Sarabia Niels Chavannes Ekaterine Chkhartishvili Derek K Chu Cemal Cingi Jaime Correia de Sousa David J Costa Anne Lise Courbis Adnan Custovic Biljana Cvetkosvki Gennaro D'Amato Jane da Silva Carina Dantas Dejan Dokic Yves Dauvilliers Giulia De Feo Govert De Vries Philippe Devillier Stefania Di Capua Gerard Dray Ruta Dubakiene Stephen R Durham Marc Dykewicz Motohiro Ebisawa Mina Gaga Yehia El-Gamal Enrico Heffler Regina Emuzyte John Farrell Jean-Luc Fauquert Alessandro Fiocchi Antje Fink-Wagner Jean-François Fontaine José M Fuentes Perez Bilun Gemicioğlu Amiran Gamkrelidze Judith Garcia-Aymerich Philippe Gevaert Maximiliano Gomez Sandra González Diaz Maia Gotua Nick A Guldemond Maria-Antonieta Guzmán Jawad Hajjam Yunuen R Huerta Villalobos Marc Humbert Guido Iaccarino Despo Ierodiakonou TomohisaIinuma Ewa Jassem Guy Joos Ki-Suck Jung Igor Kaidashev Omer Kalayci Przemyslaw Kardas Thomas Keil Musa Khaitov Nikolai Khaltaev Jorg Kleine-Tebbe Rostislav Kouznetsov Marek L Kowalski Vicky Kritikos Inger Kull Stefania La Grutta Lisa Leonardini Henrik Ljungberg Philip Lieberman Brian Lipworth Karin C Lodrup Carlsen Catarina Lopes-Pereira Claudia C Loureiro Renaud Louis Alpana Mair Bassam Mahboub Michaël Makris Joao Malva Patrick Manning Gailen D Marshall Mohamed R Masjedi Jorge F Maspero Pedro Carreiro-Martins Mika Makela Eve Mathieu-Dupas Marcus Maurer Esteban De Manuel Keenoy Elisabete Melo-Gomes Eli O Meltzer Enrica Menditto Jacques Mercier Yann Micheli Neven Miculinic Florin Mihaltan Branislava Milenkovic DimitiriosI Mitsias Giuliana Moda Maria-Dolores Mogica-Martinez Yousser Mohammad Steve Montefort Ricardo Monti Mario Morais-Almeida Ralph Mösges Lars Münter Antonella Muraro Ruth Murray Robert Naclerio Luigi Napoli Leila Namazova-Baranova Hugo Neffen Kristoff Nekam Angelo Neou Björn Nordlund Ettore Novellino Dieudonné Nyembue Robin O'Hehir Ken Ohta Kimi Okubo Gabrielle L Onorato Solange Ouedraogo Julia Palamarchuk Isabella Pali-Schöll Peter Panzner Hae-Sim Park Gianni Passalacqua Jean-Louis Pépin Ema Paulino Jim Phillips Robert Picard Hilary Pinnock Davor Plavec Todor A Popov Fabienne Portejoie David Price Emmanuel P Prokopakis Fotis Psarros Benoit Pugin Francesca Puggioni Pablo Quinones-Delgado Filip Raciborski Rojin Rajabian-Söderlund Frederico S Regateiro Sietze Reitsma Daniele Rivero-Yeverino Graham Roberts Nicolas Roche Erendira Rodriguez-Zagal Christine Rolland Regina E Roller-Wirnsberger Nelson Rosario Antonino Romano Menahem Rottem Dermot Ryan Johanna Salimäki Mario M Sanchez-Borges Joaquin Sastre Glenis K Scadding Sophie Scheire Peter Schmid-Grendelmeier Holger J Schünemann FaradibaSarquis Serpa Mohamed Shamji Juan-Carlos Sisul Mikhail Sofiev Dirceu Solé David Somekh Talant Sooronbaev Milan Sova François Spertini Otto Spranger Cristiana Stellato Rafael Stelmach Michel Thibaudon Teresa To MondherToumi Omar Usmani AntonioA Valero Rudolph Valenta Marylin Valentin-Rostan Rianne van der Kleij Michiel Van Eerd Olivier Vandenplas Tuula Vasankari Antonio Vaz Carneiro Giorgio Vezzani Frédéric Viart Giovanni Viegi Dana Wallace Martin Wagenmann De Yun Wang Susan Waserman Magnus Wickman Dennis M Williams Gary Wong Piotr Wroczynski Panayiotis K Yiallouros Osman M Yusuf Heather J Zar Stéphane Zeng Mario E Zernotti Luo Zhang Nan Shan Zhong Mihaela Zidarn

Allergy 2020 Jun 8. Epub 2020 Jun 8.

University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis.It strengthens the ARIA change management strategy in the prevention and managementof airway disease. Read More

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http://dx.doi.org/10.1111/all.14422DOI Listing
June 2020
6.028 Impact Factor

Toxic effects of perinatal maternal exposure to nonylphenol on lung inflammation in male offspring rats.

Sci Total Environ 2020 May 8;737:139238. Epub 2020 May 8.

School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, PR China. Electronic address:

The incidence of asthma and its related allergic diseases has increased dramatically over the last decade. Asthma is a complex disease caused by genetic and environmental factors. Nonylphenol (NP), a typical endocrine disrupting chemical (EDC), is a major current focus in asthma research. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139238DOI Listing

Epithelial barriers in allergy and asthma.

J Allergy Clin Immunol 2020 Jun;145(6):1499-1509

KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Unit, Leuven, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete School of Medicine, Heraklion, Crete, Greece.

The respiratory epithelium provides a physical, functional, and immunologic barrier to protect the host from the potential harming effects of inhaled environmental particles and to guarantee maintenance of a healthy state of the host. When compromised, activation of immune/inflammatory responses against exogenous allergens, microbial substances, and pollutants might occur, rendering individuals prone to develop chronic inflammation as seen in allergic rhinitis, chronic rhinosinusitis, and asthma. The airway epithelium in asthma and upper airway diseases is dysfunctional due to disturbed tight junction formation. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270816PMC

Cutaneous barrier dysfunction in allergic diseases.

J Allergy Clin Immunol 2020 Jun;145(6):1485-1497

Department of Pediatrics, National Jewish Health, Denver, Colo.

The fundamental defect(s) that drives atopic dermatitis (AD) remains controversial. "Outside in" proponents point to the important association of filaggrin gene mutations and other skin barrier defects with AD. The "inside out" proponents derive support from evidence that AD occurs in genetic animal models with overexpression of type 2 immune pathways in their skin, and humans with gain-of-function mutations in their type 2 response develop severe AD. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291847PMC

Utility of Environmental Exposure Unit Challenge Protocols for the Study of Allergic Rhinitis Therapies.

Curr Allergy Asthma Rep 2020 Jun 6;20(8):34. Epub 2020 Jun 6.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.

Purpose Of Review: This paper explores how the Environmental Exposure Unit (EEU) experimental model can be used to further our understanding of pharmacotherapies and immunotherapies for the treatment of allergic rhinitis (AR).

Recent Findings: EEUs are used increasingly for the study of combination therapies, immunotherapies, and novel AR treatments. A combined antihistamine/corticosteroid nasal spray formulation was seen to have a faster onset of action relative to the therapies individually in the Environmental Exposure Chamber. Read More

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http://dx.doi.org/10.1007/s11882-020-00922-8DOI Listing

The External Exposome and Food Allergy.

Authors:
Timothy P Moran

Curr Allergy Asthma Rep 2020 Jun 6;20(8):37. Epub 2020 Jun 6.

Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Purpose Of Review: The recent increase in childhood food allergy prevalence strongly suggests that environmental exposures are contributing to food allergy development. This review summarizes current knowledge about the role of the external exposome in food allergy.

Recent Findings: There is growing evidence that environmental exposure to food antigens in house dust through non-oral routes contributes to food sensitization and allergy. Read More

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http://dx.doi.org/10.1007/s11882-020-00936-2DOI Listing

Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.

Allergy 2020 Jun 5. Epub 2020 Jun 5.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Read More

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http://dx.doi.org/10.1111/all.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300800PMC

The impact of oral exposure to low-dose tris(2-butoxyethyl) phosphate in allergic asthmatic mice.

J Appl Toxicol 2020 Jun 4. Epub 2020 Jun 4.

Graduate School of Global Environmental Studies, Kyoto, Japan.

Tris(2-butoxyethyl) phosphate (TBEP) is a major organophosphorus flame retardant and has been widely increasing as a substitute for brominated flame retardants. TBEP may have adverse effects on human health; however, its impact on immune and allergic responses remains largely uncharacterized. In this study, the effects of low-dose TBEP comparable with the level of actual human exposure to that of human tolerable daily intake on allergic asthmatic mice were explored. Read More

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http://dx.doi.org/10.1002/jat.4001DOI Listing

Eating fish and fruits are associated with lower prevalence of allergic diseases.

Respir Med Res 2020 May 12;78:100761. Epub 2020 May 12.

Epicene Inserm Bordeaux, Laboratory - work health Environment, Institute of Public Health, Epidemiology and Development, University Bordeaux Segalen, 33076 Bordeaux, France. Electronic address:

Background: Allergic diseases are recognized as a burden on the public health. They stand as one of the most common chronic diseases, especially in developed countries. Therefore, the objective of this study is to evaluate the association between the development of atopic allergy and the presence of food allergy in children, and food consumption. Read More

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http://dx.doi.org/10.1016/j.resmer.2020.100761DOI Listing

Dog keeping at home before and during pregnancy decreased the risk of food allergy in 1-year-old children.

Postepy Dermatol Alergol 2020 Apr 6;37(2):255-261. Epub 2020 May 6.

Department of Paediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland.

Introduction: The relationship between allergen exposure to animals in pregnancy and the development of allergic symptoms is not clear.

Aim: To evaluate the association between prenatal and postnatal exposure to pet ownership and development of atopic dermatitis, food allergy and wheezing in children at the age of 1 and 2.

Material And Methods: The mother-child pairs included in this study were part of the Polish Mother and Child Cohort. Read More

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http://dx.doi.org/10.5114/ada.2018.80584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262798PMC

A butterfly flaps its wings: Extinction of biological experience and the origins of allergy.

Authors:
Susan L Prescott

Ann Allergy Asthma Immunol 2020 May 29. Epub 2020 May 29.

The ORIGINS Project, Telethon Kids Institute, University of Western Australia, Perth Children's Hospital, Nedlands, Australia; inVIVO Planetary Health of the Worldwide Universities Network, West New York, New Jersey. Electronic address:

Objective: To explore links between biodiversity on all scales and allergic disease as a measure of immune dysregulation.

Data Sources: PubMed and Web of Science were searched using the keywords biodiversity, nature relatedness, allergic disease, microbiome, noncommunicable diseases, coronavirus disease 2019, and associated terms.

Study Selection: Studies were selected based on relevance to human health and biodiversity. Read More

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http://dx.doi.org/10.1016/j.anai.2020.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256009PMC

Japanese guidelines for occupational allergic diseases 2020.

Allergol Int 2020 May 26. Epub 2020 May 26.

Division of Respiratory Medicine and Allergology, Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Occupational allergic diseases are likely to worsen or become intractable as a result of continuous exposure to high concentrations of causative allergens. These are socioeconomically important diseases that can lead to work interruptions for patients and potentially job loss. We published the first guideline for managing occupational allergic diseases in Japan. Read More

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http://dx.doi.org/10.1016/j.alit.2020.03.010DOI Listing

Diagnoses and management of adult cough: An Indian Environmental Medical Association (EMA) position paper.

Respir Med 2020 Jul 6;168:105949. Epub 2020 May 6.

Jindal Clinics, Chandigarh, India.

Background: Cough is a common yet distressing symptom that results in significant health care costs from outpatient visits and related consultations.

Objective: The understanding of the pathobiology of cough in recent times has undergone an evolution with Cough hypersensitivity syndrome (CHS) being suggested in most cases of dry cough. However, in the case of productive cough, ancillary mechanisms including impaired Mucociliary clearance, in addition to hypermucosecretory bronchospastic conditions of Smoker's cough, asthma-COPD overlap, bronchiectasis, and allergic bronchopulmonary aspergillosis, need to be critically addressed while optimizing patient care with symptomatic therapy in outpatient settings of India. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105949DOI Listing

A comparison of biologicals in the treatment of adults with severe asthma - real-life experiences.

Asthma Res Pract 2020 13;6. Epub 2020 May 13.

1Respiratory Diseases and Allergology, University of Helsinki and Helsinki University Hospital, Inflammation Center, Meilahdentie 2, FI-00029 HUS, P.O. Box 160, Helsinki, Finland.

Background: Anti-IgE (omalizumab) and anti-IL5/IL5R (reslizumab, mepolizumab and benralizumab) treatments are available for severe allergic and eosinophilic asthma. In these patients, studies have shown beneficial effects in oral corticosteroid use and exacerbations. The aim of this retrospective single-center study was to evaluate the effect of biological therapy on severe asthma and to compare different therapies. Read More

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http://dx.doi.org/10.1186/s40733-020-00055-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222440PMC