951 results match your criteria Allergic Fungal Sinusitis


Serious fungal disease incidence and prevalence in Indonesia.

Mycoses 2021 May 10. Epub 2021 May 10.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Background: Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden helps policy makers and clinicians.

Objectives: We have estimated the incidence and prevalence of serious fungal diseases. Read More

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Isolated Primary Sinonasal Adenocarcinoma of the Sphenoid Sinus.

Cureus 2021 Mar 26;13(3):e14127. Epub 2021 Mar 26.

Division of Neurological Surgery, University of Missouri School of Medicine, Columbia, USA.

Isolated lesions of the sphenoid sinus, particularly malignancies, are rarely reported and exist largely within the Otolaryngology literature. Delayed diagnosis may necessitate neurosurgical involvement; therefore, neurosurgeons must be aware of the range of pathologies in this region in order to provide adequate treatment. We present an unusual case of an 89-year-old female with several weeks of worsening headaches, vision loss, and cranial neuropathies. Read More

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Recurrence Pattern and Complication Rate of Allergic Fungal Sinusitis: A 10-Year Tertiary Center Experience.

Int J Otolaryngol 2020 18;2020:9546453. Epub 2020 Dec 18.

King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Allergic fungal rhinosinusitis is a noninvasive form of highly recurrent chronic rhinosinusitis. Despite the advancement in medical and surgical strategies, recurrence in AFRS in general poses another challenging problem with reported incidence that eventually can reach more than 60%. Recognition and understanding the pattern of disease recurrence will lead to greater understanding of the disease response in our population. Read More

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December 2020

Unilateral Exserohilum Allergic Fungal Sinusitis in a Pediatric Host: Case Report.

Int J Surg Case Rep 2020 16;77:698-700. Epub 2020 Nov 16.

Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Otolaryngology-Head & Neck Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Introduction: Allergic fungal sinusitis (AFS) is a result of an inflammatory reaction to fungi in the nasal and paranasal sinuses. Although the causative agents of AFS vary, Exserohilum species are among the rare ones, as only a few cases have ever been reported a few times in the literature. The objective of this report is to highlight this unusual fungal type causing unilateral AFS in Saudi Arabia. Read More

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November 2020

Nasal Gel Loaded with Amphotericin Nanotransferosomes as Antifungal Treatment for Fungal Sinusitis.

Pharmaceutics 2020 Dec 28;13(1). Epub 2020 Dec 28.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

On the basis of fungal involvement, rhinosinusitis is categorized into allergic, mycetoma, chronic, and acute invasive types. The aim of the current study was to evaluate the efficacy of an amphotericin gel in situ loaded with nanotransferosomes against , which causes allergic rhinosinusitis. A Box-Behnken design was utilized to study the interaction among the nanotransferosomes and optimize independent variables in formulating them, in order to match the prerequisites of selected responses. Read More

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December 2020

Monoclonal Antibodies and Airway Diseases.

Int J Mol Sci 2020 Dec 13;21(24). Epub 2020 Dec 13.

Inflammation Centre, Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, P.O. Box 160, 00029 HUS Helsinki, Finland.

Monoclonal antibodies, biologics, are a relatively new treatment option for severe chronic airway diseases, asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). In this review, we focus on the physiological and pathomechanisms of monoclonal antibodies, and we present recent study results regarding their use as a therapeutic option against severe airway diseases. Airway mucosa acts as a relative barrier, modulating antigenic stimulation and responding to environmental pathogen exposure with a specific, self-limited response. Read More

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December 2020

Evaluation of Smoking as a Modifying Factor in Chronic Rhinosinusitis.

JAMA Otolaryngol Head Neck Surg 2021 02;147(2):159-165

James Paget University Hospital National Health Service (NHS) Foundation Trust, Gorleston, England.

Importance: The negative association of smoking with the respiratory tract is well known; however, the association between smoking and chronic rhinosinusitis (CRS) has not been well characterized.

Objective: To analyze whether active smoking was a risk factor for CRS development, smoking was associated with disease-specific quality of life, and smokers experience an increased symptom burden than nonsmokers.

Design, Setting, And Participants: This subanalysis of the Chronic Rhinosinusitis Epidemiology Study (CRES), a prospective, questionnaire-based case-control study conducted between October 2007 and September 2013 was conducted across 30 UK tertiary/secondary care sites. Read More

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February 2021

The Woes of a Stuffy Nose: A Case Report of Allergic Fungal Sinusitis.

Clin Pract Cases Emerg Med 2020 Nov;4(4):569-571

Naval Medical Center Portsmouth, Department of Emergency Medicine, Portsmouth, Virginia.

Introduction: Allergic fungal sinusitis (AFS) is a relatively uncommon cause of sinus pain and congestion. Extreme cases may require specialty evaluation and surgical treatment.

Case Report: In this case, an otherwise healthy young man presented to the emergency department with sinus pain and congestion for two weeks and was admitted to surgery for resection of his AFS. Read More

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November 2020

Fungal sinusitis: a spectrum of disease.

Int Forum Allergy Rhinol 2021 May 13;11(5):935-937. Epub 2020 Nov 13.

Department of Otolaryngology Head and Neck Surgery, University of Texas Southwestern, Dallas, TX.

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Optic nerve compression due to allergic fungal rhinosinusitis.

BMJ Case Rep 2020 Nov 9;13(11). Epub 2020 Nov 9.

Otorhinolaryngology-Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

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November 2020

Hypertrophic pachymeningitis caused by Schizophyllum sp.: a novel case report.

Infection 2020 Nov 6. Epub 2020 Nov 6.

Tokyo Medical University Hospital, Department of Infection Prevention and Control, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: The pathogenic fungus Schizophyllum sp. can cause allergic fungal rhinosinusitis and allergic bronchopulmonary mycosis in humans. Sinus and lung infections due to Schizophyllum sp. Read More

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November 2020

Pneumonia due to in a Patient with Acute Myeloid Leukemia: Case Report and Literature Review.

Infect Chemother 2020 09 18. Epub 2020 Sep 18.

Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

is a mold in phylum Basidiomycota and is an uncommon human pathogen. Sinusitis and allergic bronchopulmonary mycosis are the two major diseases caused by . Although there have been several reports of invasive fungal diseases, most of them were invasive sinusitis. Read More

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September 2020

Co-infection of With Bacterial Pathobionts or Leads to Distinct Sinonasal Inflammatory Responses in a Murine Acute Sinusitis Model.

Front Cell Infect Microbiol 2020 4;10:472. Epub 2020 Sep 4.

Center for Applied Microbiome Sciences, The Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.

Host-associated bacteria and fungi, comprising the microbiota, are critical to host health. In the airways, the composition and diversity of the mucosal microbiota of patients are associated with airway health status. However, the relationship between airway microbiota and respiratory inflammation is not well-understood. Read More

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September 2020

Pediatric allergic fungal rhinosinusitis with extensive intracranial extension - Case report and literature review.

Int J Surg Case Rep 2020 12;75:437-440. Epub 2020 Sep 12.

Department of Medical Imaging at King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Introduction: Over the last two decades, allergic fungal sinusitis (AFRS) has become increasingly common. It's defined as a noninvasive, benign inflammatory fungal disease of the sinuses which develops in young adults and adolescents. Patients often complain of symptoms like nasal obstruction, congestion, purulent or clear rhinorrhea, anosmia, and headache. Read More

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September 2020

Sinister sinusitis.

Arch Dis Child Educ Pract Ed 2020 Sep 15. Epub 2020 Sep 15.

Paediatric Rheumatology, Evelina London Children's Hospital, London, UK.

Two previously well Caucasian teenage girls with no significant travel or family history were admitted with sinusitis refractory to treatment with antibiotics. Both had progressive symptoms despite broad-spectrum antibiotics and developed involvement of other systems, ultimately requiring admission to the paediatric intensive care unit (PICU). They were subsequently diagnosed with the same condition and made an excellent recovery. Read More

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September 2020

Allergic fungal sinusitis masquerading as cavernous sinus thrombosis.

J Surg Case Rep 2020 Aug 24;2020(8):rjaa233. Epub 2020 Aug 24.

Department of Ophthalmology, Loma Linda University Medical School, Loma Linda, California.

Allergic fungal sinusitis (AFS), a noninvasive form of fungal sinusitis, is rarely seen in immunocompetent patients. Involvement of sphenoid sinus can result in proptosis and loss of vision. We report AFS masquerading as posterior cavernous sinus syndrome. Read More

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Clinical, Radiological, and Histopathological Patterns of Allergic Fungal Sinusitis: A Single-Center Retrospective Study.

Cureus 2020 Jul 17;12(7):e9233. Epub 2020 Jul 17.

Otolaryngology-Head and Neck Surgery, Jeddah University, Jeddah, SAU.

Objectives To explore the clinical, pathological, and imaging characteristics of allergic fungal sinusitis (AFS) and to analyze the correlation of disease duration with imaging and histopathology findings. Methods We reviewed all cases of AFS managed at the otorhinolaryngology department of King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia. Demographic and clinical features were collected, as well as imaging and histopathological findings, which were analyzed by time from onset. Read More

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Mycosis of the Plantar Surface of Foot Owing to Nondermatophyte Mold Nodulisporium griseobrunneum Mimicking a Tinea Pedis.

Mycopathologia 2020 Dec 20;185(6):1033-1040. Epub 2020 Aug 20.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Nondermatophyte molds (NDM) and dematiaceous molds are less frequently implicated as the etiological agents of tinea-like infections of the foot. Among the etiological agents, Hendersonula toruloidea (now, Nattrassia mangiferae), Scytalidium hyalinum, Alternaria species (spp.), and Fusarium spp. Read More

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December 2020

Dupilumab use in recalcitrant allergic fungal rhinosinusitis.

Ann Allergy Asthma Immunol 2020 11 21;125(5):617-619. Epub 2020 Jul 21.

Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics Stanford University School of Medicine, Stanford, California.

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November 2020

A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease.

Am J Rhinol Allergy 2021 Mar 13;35(2):172-178. Epub 2020 Jul 13.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized.

Objective: The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls. Read More

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Contemporary Classification of Chronic Rhinosinusitis Beyond Polyps vs No Polyps: A Review.

JAMA Otolaryngol Head Neck Surg 2020 09;146(9):831-838

Rhinology and Skull Base Research Group, St Vincent's Centre for Applied Medical Research, University of New South Wales, Sydney, New South Wales, Australia.

Importance: Chronic rhinosinusitis (CRS) is a broadly defined process that has previously been used to describe many different sinonasal pathologic conditions from odontogenic sinusitis and allergic fungal sinusitis to the more contemporary definition of broad inflammatory airway conditions. Previous classification systems have dichotomized these conditions into CRS with nasal polyps and CRS without nasal polyps. However, clinicians are learning more about the inflammatory subtypes of CRS, which can lead to improved delivery and effectiveness of treatment. Read More

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September 2020

Allergic Fungal Sinusitis Imitating an Aggressive Skull Base Lesion in the Setting of Pembrolizumab Immunotherapy.

Ann Otol Rhinol Laryngol 2021 Jan 29;130(1):108-111. Epub 2020 Jun 29.

Department of Otolaryngology-Head & Neck Surgery, Oregon Health and Science University, Portland, OR, USA.

Objectives: We report a case of acutely worsening allergic fungal sinusitis in a patient receiving immunotherapy with pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor.

Methods: A 53-year-old man with a history of metastatic melanoma and recent initiation of pembrolizumab therapy presented with acutely worsening headaches, left abducens nerve palsy, and neuroimaging demonstrating an erosive skull base lesion with bilateral cavernous sinus involvement.

Results: Intraoperative findings were consistent with non-invasive allergic fungal sinus disease. Read More

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January 2021

[Subcutaneous infection by Curvularia pallescens in a lung transplant recipient: First report in Spain].

Rev Iberoam Micol 2020 Apr - Jun;37(2):58-62. Epub 2020 Jun 19.

Servicio de Microbiología, Hospital Universitario Central de Asturias, Fundación para la Investigación y la Innovación Biosanitaria del Principado de Asturias (FINBA), Oviedo, Asturias, España.

Background: Curvularia is a filamentous dematiaceous fungus increasingly recognized as a pathogen in immunocompromised patients. The most common clinical entities associated with this fungus are allergic sinusitis, cutaneous infection and keratitis. In this article, a report on the first clinical case of Curvularia pallescens cutaneous infection in Spain and its treatment is described. Read More

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Development and immunopathological characteristics of an Alternaria-induced chronic rhinosinusitis mouse model.

PLoS One 2020 16;15(6):e0234731. Epub 2020 Jun 16.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu, South Korea.

Airborne fungi are associated with upper and lower airway inflammatory diseases. Alternaria is commonly found in nasal secretions and induces the production of chemical mediators from sinonasal mucosa. This study aimed to establish an Alternaria-induced chronic rhinosinusitis (CRS) mouse model and determine the influence of host allergic background on the immunopathological characteristics of CRS. Read More

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The Role of Home Fungal Exposure in Allergic Fungal Rhinosinusitis.

Am J Rhinol Allergy 2020 Nov 15;34(6):784-791. Epub 2020 Jun 15.

Division of Rhinology and Sinus Surgery, Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Allergic fungal rhinosinusitis (AFRS) is disproportionately identified in patients of low socioeconomic status living in warm, humid climates, and is thought to occur in response to environmental fungal species.

Objective: We hypothesized that micro-geographic differences in fungal exposure contribute to the pathogenesis of AFRS, and compared home fungal exposure of patients with AFRS to normative data and controls.

Methods: Comprehensive prospective enrollment and data capture was completed in 70 patients. Read More

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November 2020

Orbital cellulitis, sinusitis and intracranial abnormalities in two adolescents with COVID-19.

Orbit 2020 Aug 18;39(4):305-310. Epub 2020 May 18.

Department of Radiology, Rutgers New Jersey Medical School , Newark, New Jersey, USA.

We review two cases of adolescents with orbital cellulitis, sinusitis and SARS- CoV-2 infection presenting to emergency departments within a 24 hour period. SARS-CoV-2 samples obtained within 24 hours were positive, supporting prior infection despite relatively limited early symptoms of COVID-19. Unusual clinical and radiographic characteristics included hemorrhagic abscess with blood of varying age in the first, intracranial epidural abscess in the second, radiographic signal consistent with hemorrhagic or thrombotic phenomena, retro-maxillary antral fat changes, and meningeal enhancement or extension in both cases. Read More

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Fungal Pneumonia in The Immunocompetent Host: A Possible Statistical Connection Between Allergic Fungal Sinusitis with Polyposis and Recurrent Pulmonary Infection Detected by Gastroesophageal Reflux Disease Scintigraphy.

Mol Imaging Radionucl Ther 2020 Apr;29(2):72-78

University of Notre Dame, CNI Molecular Imaging, Sydney, Australia.

Objectives: Fungal pneumonia in the immune competent host is a rarity with few reported cases in the literature. We present a series of 7 cases of recurrent fungal pneumonia in association with allergic fungal rhinosinusitis and gastroesophageal reflux disease (GERD). We hypothesised that recurrent infection may have been transported from the infected paranasal sinuses into the lung by GERD as the process was terminated by surgical fundoplication in 2 of these patients. Read More

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Extramedullary Hematopoiesis in the Sinonasal Cavity: A Case Report and Review of the Literature.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720918874. Epub 2020 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina.

Background: Extramedullary hematopoiesis (EMH) occurs in patients with hematologic disorders, but rarely within the paranasal sinuses. We report a case of EMH in a 17-year-old male with sickle cell disease (SCD) who presented with occipital pain and sinusitis. A computed tomography (CT) scan demonstrated heterogeneous opacification of the right maxillary sinus concerning for allergic fungal sinusitis or a fungal ball with bony erosion. Read More

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Allergic Fungal rhino-sinusitis frequency in chronic rhino-sinusitis patients and accuracy of fungal culture in its diagnosis.

Pak J Med Sci 2020 Mar-Apr;36(3):555-558

Dr. Samina Qamar, FCPS. Department of Pathology, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.

Objective: To determine the frequency of Allergic Fungal Rhino-sinusitis (AFRS) in Chronic Rhino-sinusitis (CRS) patients and the accuracy of fungal culture in diagnosing AFRS.

Methods: Immunocompetent patients with CRS and without invasive fungal rhino-sinusitis presenting over a period of 3 years in ENT department of Mayo Hospital, from April 2014 to September 2017 were included in the study. AFRS was diagnosed clinically and on Bent and Kuhn diagnostic criteria. Read More

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Current Concepts in the Management of Allergic Fungal Rhinosinusitis.

Immunol Allergy Clin North Am 2020 05 29;40(2):345-359. Epub 2020 Jan 29.

Department of Otorhinolaryngology-Head & Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Texas Sinus Institute, 6431 Fannin Street, MSB 5.036, Houston, TX 77030, USA; Center for Immunology and Autoimmune Diseases, Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA. Electronic address:

Allergic fungal rhinosinusitis (AFRS) represents a subtype of chronic rhinosinusitis with nasal polyposis that exhibits a unique, often striking clinical presentation. Since its initial description more than a quarter century ago, a more sophisticated understanding of the pathophysiology of AFRS has been achieved and significant advancements in improving clinical outcomes made. This review focuses on the latest developments involving the pathophysiology and clinical management of this fascinating disease. Read More

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