Search Our Scientific Publications & Authors

J Maxillofac Oral Surg 2019 Jun 28;18(2):164-179. Epub 2019 Jan 28.

Department of Oral and maxillofacial Surgery, PGIDS, Pt. BD Sharma University of Health Sciences, Rohtak, Haryana 124001 India.

Fungal rhinosinusitis (FRS), once considered a rare disease, has seen a steep rise in incidence in recent times. This global rise in the burden of fungal disease is a consequence of an increment in the population with weakened immune systems. Increased life expectancy with rise in conditions like diabetes mellitus, medical advancements with invasive interventions, use of immunosuppressive drugs and chemo-radiotherapy all lead to unique risk situations. Read More

Maxillofac Plast Reconstr Surg 2019 Dec 29;41(1):13. Epub 2019 Mar 29.

Oral and Maxillofacial Microvascular Reconstruction LAB, Ghana Health Service, Brong Ahafo Regional Hospital, P.O. Box 27, Sunyani, Brong Ahafo Ghana.

Background: Maxillary sinusitis of odontogenic origin, also known as maxillary sinusitis of dental origin or odontogenic maxillary sinusitis (OMS), is a common disease in dental, otorhinolaryngologic, allergic, general, and maxillofacial contexts. Despite being a well-known disease entity, many cases are referred to otorhinolaryngologists by both doctors and dentists. Thus, early detection and initial diagnosis often fail to detect its odontogenic origin. Read More

Laryngoscope 2019 Apr 14. Epub 2019 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, UNC Neuroscience Hospital, Chapel Hill, North Carolina, U.S.A.

Objectives: Investigate the current trends in otolaryngic allergy (OA).

Study Design: Cross-sectional survey.

Methods: Survey of active AAOA membership. Read More

Curr Allergy Asthma Rep 2019 Mar 11;19(4):21. Epub 2019 Mar 11.

Department of Head and Neck Surgery, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Ave., CHS 62-132, Los Angeles, CA, 90095-1624, USA.

Purpose Of Review: Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps (CRSwNP). The presence of S. Read More

Laryngoscope 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, Georgia.

A review of the treatment of allergic and invasive fungal sinusitis, as well as a presentation of the first recorded case of a conversion from allergic fungal sinusitis (AFS) to chronic granulomatous invasive sinusitis and the fourth case of invasive fungal sinusitis associated with Curvularia. This immunocompetent patient suffering from chronic AFS converted after repeated high-dose steroid tapers and noncompliance. AFS may present atypically and should be suspected even in immunocompetent patients with sinus disease who report new onset pain and neurologic symptoms. Read More

Iran J Allergy Asthma Immunol 2019 Feb;18(1):27-37

Department of Biochemistry, Adnan Menderes University Medical School, Aydın, Turkey.

The effects of comorbidities on systemic inflammation markers in stable asthmatics and the consequences of such effects have not been well evaluated. We aimed to evaluate the effect of comorbidities on clinical manifestations and systemic inflammation in asthmatic patients under control. The study group consisted of asthmatic patients who applied to our pulmonology outpatient clinic and volunteered to participate. Read More

Laryngoscope Investig Otolaryngol 2019 Feb 20;4(1):13-17. Epub 2018 Dec 20.

Department of Otolaryngology-Head & Neck Surgery Emory University School of Medicine Atlanta Georgia U.S.A.

Objective: To summarize the current evidence regarding a relationship between chronic rhinosinusitis (CRS) and allergy.

Methods: Literature review.

Results: Despite frequent assumption of an association between CRS and allergy the relationship between these entities remains poorly defined. Read More

J Mycol Med 2019 Apr 6;29(1):59-61. Epub 2019 Feb 6.

SSA, IRD, IHU - Méditerranée Infection, VITROME, Aix-Marseille Université, AP-HM, 13005 Marseille, France.

Fungus ball is the most common form of non-invasive fungal rhinosinusitis. Aspergillusfumigatus (between 44.8% and 75%) and Aspergillusflavus (14%) are the two most common species recovered. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):38-45

Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the regulation of IL-25 on type Ⅱ innate lymphoid cells (ILC2s) activation in the pathogenesis of allergic fungal rhinosinusitis (AFRS). Nasal mucosa tissues were collected from 16 AFRS patients and 12 patients, who underwent nasal endoscopic surgery for cerebrospinal rhinorrhea or skull base benign tumor during the period from June 2016 to June 2017 in Department of Rhinology, the First Affiliated Hospital of Zhengzhou University. Firstly, flow cytometry was used to detect ILC2s in nasal mucosa of both groups. Read More

Am J Rhinol Allergy 2019 Jan 24:1945892419825695. Epub 2019 Jan 24.

2 Division of Rhinology and Sinus Surgery, Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina.

Background: Allergic fungal rhinosinusitis (AFRS) is characterized by higher revision endoscopic sinus surgery (ESS) rates and unique radiographic features when compared to chronic rhinosinusitis with nasal polyposis (CRSwNP) or chronic rhinosinusitis without nasal polyposis (CRSsNP).

Objective: We hypothesized that an increased frequency of concha bullosa in AFRS or other radiographic nuances might allow for accumulation of allergic mucin and contribute to increased ESS revision rates.

Methods: A retrospective cohort study was performed. Read More

Molecules 2019 Jan 19;24(2). Epub 2019 Jan 19.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

L. (Asteraceae) is a common and well-known traditional Chinese herbal medicine usually named Cang-Er-Zi, and has been used for thousands of years in China. The purpose of this paper is to summarize the progress of modern research, and provide a systematic review on the traditional usages, botany, phytochemistry, pharmacology, pharmacokinetics, and toxicology of the . Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):803-808

Department of Clinical Laboratory, Third Affiliated Hospital of Guizhou Medical University,Tuyun,Guizhou 558000,China.

Objective To analyze the risk factors of multidrug-resistant bacterial infections in patients with chronic rhinosinusitis.Methods The clinical data of 221 patients with chronic rhinosinusitis who were treated in our center from January 2010 to January 2017 were collected retrospectively. Specimens were collected for bacterial culture and antibiotic susceptibility testing. Read More

Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More

Int J Surg Case Rep 2019 16;54:60-62. Epub 2018 Nov 16.

Consultant ENT, Rhinology and Endoscopic Skull Base Surgery at King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objectives: to report the alternating nature of allergic fungal rhinosinusitis in children in the Eastern part of Saudi Arabia and to review the experience of King Fahad Specialist Hospital in the diagnosis and management of alternating allergic fungal rhinosinusitis in children. An 8 years old Saudi girl with alternating allergic fungal rhinosinusitis was diagnosed and managed. The patient was diagnosed to have unilateral left allergic fungal rhinosinusitis and underwent endoscopic sinus surgery and cleaning of the left sinuses from polyps, mud and mucin. Read More

World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.

McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.

Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More

Clin Otolaryngol 2019 Jan 25;44(1):91-96. Epub 2018 Nov 25.

Department of Oto-Rhino-Laryngology - Head and Neck Surgery, Aix-Marseille Univ, APHM, CNRS, IUSTI, Conception, Marseille, France.

Am J Rhinol Allergy 2019 Jan 24;33(1):83-93. Epub 2018 Oct 24.

4 Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, UK.

Objectives: We reviewed the phenotyping and endotyping of chronic rhinosinusitis (CRS) and treatment options.

Methods: We searched PubMed, Google, Google Scholar, and the Proquest Central Database of the Kırıkkale University Library.

Results: Phenotypes are observable properties of an organism produced by the environment acting upon the genotype, that is, patients with a particular disorder are subgrouped according to common characteristics. Read More

Cochrane Database Syst Rev 2018 09 10;9:CD012453. Epub 2018 Sep 10.

Cochrane ENT, Nuffield Department of Surgical Sciences, University of Oxford, UK Cochrane Centre, Summertown Pavilion, 18 - 24 Middle Way, Oxford, UK.

Background: This review adds to a series of reviews looking at primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Read More

Otolaryngol Pol 2018 Jun;72(4):35-41

Samodzielny Publiczny Szpital Kliniczny nr 7 Śląskiego Uniwersytetu Medycznego w Katowicach Górnośląskie Centrum Medyczne im. prof. Leszka Gieca Oddział Laryngologii i Onkologii Laryngologicznej.

Introduction: Fungal paranasal sinusitis can be either invasive or non-invasive. Saprophytic infections, fungus balls (FB) and allergic fungal rhinosinusitis are non-invasive (AFR).

Materials And Methods: The present study examined 521 patients who underwent endoscopic sinus surgery between January 2016 and April 2017 due to chronic paranasal sinusitis at the Department of Laryngology and Laryngological Oncology of the Upper Silesian Medical Centre in Katowice. Read More

Cochrane Database Syst Rev 2018 09 5;9:CD008263. Epub 2018 Sep 5.

St Vincent's Clinical School, St Vincent's Hospital, 806/438 Victoria St, Darlinghurst, Sydney, Australia, NSW 2010.

Background: Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and sinuses. Since fungi were postulated as a potential cause of CRS in the late 1990s, there has been increasing controversy about the use of both topical and systemic antifungal agents in its management. Although interaction between the immune system and fungus has been demonstrated in CRS, this does not necessarily imply that fungi are the cause of CRS or that antifungals will be effective its management. Read More

Mycopathologia 2019 Feb 30;184(1):89-96. Epub 2018 Aug 30.

Department of Microbiology, Faculty of Medicine, Kuwait University, P. O. Box 24923, Safat, 1311, Kuwait.

A case of allergic fungal sinusitis (AFS) caused by Exserohilum rostratum, proven by culture and histopathology of the biopsy material, is described. The identity of the isolate was confirmed by sequencing of ITS region of rDNA. To the best of our knowledge, this is the first report of allergic E. Read More

Allergol Immunopathol (Madr) 2018 Nov - Dec;46(6):599-606. Epub 2018 Jul 25.

Department of Applied Biology, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria.

Introduction And Objectives: Aeroallergens are airborne organic substances which are responsible for allergenic diseases in hypersensitive individuals. People are exposed to their allergens either directly or after their entrance into the interiors. The spatio-temporal pattern of aeroallergens and their relationship with weather variability in Abuja and Nassarawa, North-Central Nigeria was studied. Read More

J Biol Regul Homeost Agents 2018 Jul-Aug;32(4):763-768

Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy.

Molds include all species of microscopic fungi, the spores of which are small molecules, ubiquitous, mostly found in soil with higher rainfall and high humidity, in the atmosphere of urban and rural settings and in decaying vegetation. They originate from pathogenic fungi and have a crucial role in inflammatory response, causing a broad range of diseases. Immune suppressed subjects may develop mycoses caused by opportunistic common pathogenic fungi. Read More

Presse Med 2018 Jul - Aug;47(7-8 Pt 1):625-638. Epub 2018 Jul 21.

Radiologie neuro-ORL et ostéo-articulaire, hôpital Edouard-Herriot, pavillon B, 5, place d'Arsonval, 69437 Lyon cedex 03, France.

Among fungal infections of the nasal sinuses, allergic fungal rhinosinusitis is a recently described, relatively rare and little known pathology. Its diagnosis is based on: clinical criteria (it occurs in young immunocompetent patients, often associated with bilateral nasosinusal polyposis); pathological criteria (allergic mucin: eosinophilic mucus without invasion of the sinusal mucosa and observation of fungal hyphae on surgical samples); biological criteria (hypereosinophilia, total and specific antifungal IgE); and radiological criteria. The combination of tomodensitometry (heterogeneous hyperdense and diffuse filling of nasosinusal cavities with expanded borders and a distended appearance of the bony wall), and MRI scan (extensive character and lesional signal [hypo and asignal T1 and T2], and cerebriform aspect of the fungal process) strongly suggests the diagnosis. Read More

Perm J 2018 ;22:17-230

Associate Professor in the Department of Ear, Nose, and Throat and Head and Neck Surgery at Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, in Pillaiyarkuppam, Pondicherry, India.

Respir Res 2018 06 27;19(1):129. Epub 2018 Jun 27.

Norwich Medical School, University of East Anglia, Norfolk, NR4 7TJ, UK.

Background: Chronic rhinosinusitis (CRS) is a common disorder associated with other respiratory tract diseases such as asthma and inhalant allergy. However, the prevalence of these co-morbidities varies considerably in the existing medical literature and by phenotype of CRS studied. The study objective was to identify the prevalence of asthma, inhalant allergy and aspirin sensitivity in CRS patients referred to secondary care and establish any differences between CRS phenotypes. Read More

Int Forum Allergy Rhinol 2018 10 13;8(10):1184-1189. Epub 2018 Jun 13.

Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA.

Background: The endocannabinoid system represents a highly conserved, innate signaling network with direct and indirect control of eicosanoid-mediated inflammation. Activation of the type 2 cannabinoid receptor (CB2R) leads to decreased type 2 inflammation and reduced production of arachidonic acid (AA). Given that altered AA metabolism is associated with aspirin-exacerbated respiratory disease (AERD), we hypothesized that expression of the CB2R gene CNR2 is increased in AERD. Read More

Int Forum Allergy Rhinol 2018 09 31;8(9):1047-1051. Epub 2018 May 31.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic in Arizona, Phoenix, AZ.

Background: Revision surgery rates following endoscopic sinus surgery (ESS) range between 7% and 50% and are influenced by many factors. This study investigates ESS outcomes for chronic rhinosinusitis (CRS) subtypes.

Methods: Retrospective review of adult CRS patients undergoing ESS with a single surgeon (2010-2015) was conducted. Read More

Curr Allergy Asthma Rep 2018 May 29;18(7):37. Epub 2018 May 29.

Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Purpose Of Review: Pediatric chronic rhinosinusitis (CRS) is a common disorder that carries significant morbidity. The diagnosis requires sinus symptoms that persist despite standard medical therapy greater than 3 months. Viral infections, allergies, and anatomic differences in children lead to chronic obstruction of the osteomeatal complex. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Feb;32(4):308-311;317

Chronic rhinosinusitis (CRS) is a common disease of otolaryngology, which has a serious impact on the quality of life of patients. Its pathogenesis is complex and involves in allergic reactions, bacterial and fungal infections, immune dysfunction, impaired epithelial defense, environmental exposure and many other factors. In recent years, a raising attention has been paid to the role of immune mechanism in its pathogenesis; this article is a brief review aimes to the immune mechanism of chronic rhinosinusitis in recent years. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Dec;31(23):1824-1827;1832

Department of Otorhinolaryngology, the First Hospital of Harbin.

To investigate the imaging characteristics of bony erosion, fungal culture and related factors in allergic fungal rhinosinusitis (AFRS). Sixty cases of AFRS were reviewed in this study. The characteristics of Computed Tomography and Magnetic Resonance Imaging including positive rate of bony erosion, eroded sites, disease extension and sinus expansion were summarized. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jul;31(14):1086-1088

Department of Otolaryngology, Fifth Hospital in Wuhan, Wuhan, 430050, China.

To analyze the causes, imaging diagnosis, clinical characteristics and clinical effect of the endoscopic surgery of non-invasive fungal rhino-sinusitis.A retrospective analysis of 48 patients diagnosed with fungal sinusitis by pathology.Forty-eight cases of 40 cases are fungal sinusitis (40/48), the other 8 cases are allergic fungal rhinosinusitis. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Apr;32(7):541-544

Department of Rhinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052,China.

To evaluate the effects of combined treatment with FESS on postoperative recurrent allergic fungal rhinosinusitis treatment.Eighty-seven patients with allergic fungal sinusitis under combined treatment were investigated.All patients were followed up for more than one year. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Feb;32(3):220-224

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, and Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730, China.

The aim of this study is to investigate the clinical features of different subtypes of fungal ball sinusitis. Four hundred and forty-nine cases with fungal ball rhinosinusitis (FBS) were involved in this retrospective analysis. The clinical features including symptoms, signs, and imaging scans, pathological results were all collected for each patient and the patients were classified into different subtypes according to these clinical features and the follow-up treatment. Read More

Front Microbiol 2018 3;9:583. Epub 2018 Apr 3.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

can cause different allergic diseases including allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS). ABPA is allergic pulmonary disease against antigens. AFRS is a type of chronic rhinosinusitis (CRS) presented as hypersensitivity reactions to the fungal presence in sinuses. Read More

Otolaryngol Head Neck Surg 2018 Jul 27;159(1):185-193. Epub 2018 Mar 27.

1 Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, Texas, USA.

Objective Allergic fungal rhinosinusitis (AFRS) is a clinical subtype of chronic rhinosinusitis with nasal polyps (CRSwNP), characterized by eosinophilic mucin, evidence of fungal elements within the mucin, fungal-specific type I hypersensitivity, and characteristic computed tomography findings. It remains controversial whether AFRS represents a disease with a unique pathophysiology from chronic rhinosinusitis or is merely a severe form of CRSwNP. The goal of this study was to identify molecular features unique to AFRS. Read More

Eur Arch Otorhinolaryngol 2018 Jun 22;275(6):1439-1447. Epub 2018 Mar 22.

Department of Otolaryngology Head and Neck surgery, Beijing Tongren Hospital, CMU, No. 1 Dongjiao Folk Lane, Dongcheng District, Beijing, 100730, China.

Objective: To compare the microbiological features in middle meatus samples from chronic rhinosinusitis (CRS) patients with nasal polyps (CRSwNP) and those without nasal polyps (CRSsNP), and control subjects.

Methods: A total of 136 CRSwNP patients, 66 CRSsNP patients, and 49 control subjects who underwent endoscopic surgery in Beijing TongRen Hospital were enrolled between January 2014 and January 2016. Swab samples were obtained from the middle meatus during surgery and processed for the presence of aerobic and non-aerobic bacteria and fungi. Read More

Med Mycol 2019 Apr;57(3):270-276

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aspergillus fumigatus is the most common Aspergillus species worldwide; however, A. flavus has also been shown to be prevalent in North India. Herein, we investigate the prevalence of sensitization to A. Read More

Am J Otolaryngol 2018 Jul - Aug;39(4):441-444. Epub 2018 Mar 7.

Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy.

Purpose: Endotyping chronic rhinosinusitis with nasal polyps (CRSwNP) poses a challenge for rhinologists nowadays. Phenotyping CRSwNP proved inappropriate as an approach to their classification because of their common clinical features. Endotyping, being based on the pathogenic mechanism, provides a precise picture more appropriate for use in clinical practice. Read More

Indian J Pediatr 2018 Oct 17;85(10):899-904. Epub 2018 Mar 17.

Department of Otolaryngology, PGIMER, Chandigarh, India.

Asthma is an allergic, respiratory disorder characterized by hyper responsiveness of the airway to external stimuli. Considerable research is currently being directed towards understanding the role of environmental and genetic factors contributing to the development of asthma and its severity. Recent years have seen a substantial rise in evidence linking fungi to asthma. Read More

Int Immunopharmacol 2018 Apr 22;57:55-61. Epub 2018 Feb 22.

Department of Microbiology, University College of Medical Sciences (University of Delhi) and Guru Teg Bahadur Hospital, Delhi 110095, India; Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia. Electronic address:

Interleukin-17 producing T helper (Th17) and regulatory T cells (Treg) cells have been identified to play a critical role in atopic inflammation. However, conflicting reports on the role of Th17/Treg cells in allergic fungal rhinosinusitis (AFRS) patients of different ethnicities has mystified its pathogenesis. To better understand the pathophysiological mechanisms involved in AFRS, we conducted a prospective, analytical, case-control study involving 40 confirmed immunocompetent AFRS patients and 20 healthy controls. Read More

Asia Pac Allergy 2018 Jan 25;8(1):e7. Epub 2018 Jan 25.

Department of Otorhinolaryngology - Head and Neck Surgery, University of Siena, 53100 Siena, Italy.

Background: Allergic rhinitis (AR) is a global health problem and is characterised by one or more symptoms, including sneezing, itching, nasal congestion and rhinorrhea.

Objective: We investigated the features of AR and the physician's approach to the management of AR patients in four geographical regions.

Methods: In this cross-sectional study, a questionnaire survey concerning AR was completed by Honorary and Corresponding Members of the Italian Society of Rhinology from different countries among 4 world geographical regions-Asia, Europe, the Americas, and Africa. Read More

Ophthalmic Plast Reconstr Surg 2018 Sep/Oct;34(5):463-466

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Purposes: To study the ophthalmic manifestations of patients with allergic fungal sinusitis (AFS) and evaluate the importance of early diagnosis and management in preventing the possible future complications of AFS.

Methods: Retrospective chart review of 100 patients with the diagnosis of AFS from a single institution was performed. Age, gender, clinical presentation including ophthalmic and radiological findings, immune status, patterns of sinus involvement, medical and surgical intervention needed, laboratory results, and the course of the disease were evaluated. Read More

J Fungi (Basel) 2016 Dec 8;2(4). Epub 2016 Dec 8.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.

Allergic fungal rhinosinusitis (AFRS) is a unique variety of chronic polypoid rhinosinusitis usually in atopic individuals, characterized by presence of eosinophilic mucin and fungal hyphae in paranasal sinuses without invasion into surrounding mucosa. It has emerged as an important disease involving a large population across the world with geographic variation in incidence and epidemiology. The disease is surrounded by controversies regarding its definition and etiopathogenesis. Read More

World J Otorhinolaryngol Head Neck Surg 2017 Mar 27;3(1):59-63. Epub 2017 Mar 27.

Mycological Laboratory, Department of Dermatology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West YanJiang Rd, GuangZhou, GuangDong, 510120, PR China.

A case of allergic fungal sinusitis (AFS) due to Schizophyllum commune was reported. The pathogen was identified using molecular bioanalysis. The patient underwent the functional endoscopic sinus surgery followed by the radical maxillary sinusotomy with canine fossa trephine. Read More

World J Otorhinolaryngol Head Neck Surg 2017 Mar 6;3(1):49-53. Epub 2017 Mar 6.

Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.

Objective: The clinical presentation of sphenoid sinusitis can be highly variable. Rarely, sphenoid sinusitis may present with cranial nerve complications due to the proximity of these structures to the sphenoid sinus.

Method: A case series from Rabin Medical Center and all cases of cranial nerves palsies secondary to sphenoid sinusitis that have been reported in the literature were reviewed. Read More

Med Mycol J 2017 ;58(4):J127-J132

Department of Pathology, Kindai University Faculty of Medicine.

 Fungal sinusitis is divided into two categories depending on mucosal invasion by fungus, i.e., invasive and noninvasive. Read More

Ann Allergy Asthma Immunol 2018 07 20;121(1):61-64. Epub 2017 Nov 20.

Allergy Research Unit, Kingston General Hospital, Kingston, Ontario, Canada; Departments of Medicine and Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Objective: To summarize studies highlighting recent advances in rhinitis-related research in the past 2 years.

Data Sources: Original research articles were procured and examined from the Rhinitis and Upper Airway Disease section of the 2015 to 2017 Annals of Allergy, Asthma & Immunology issues. Additional original research articles were identified from PubMed and Google Scholar using the following search terms: allergic rhinitis, rhinitis, chronic rhinosinusitis, environmental exposure unit, and nasal allergen challenge. Read More

Int Forum Allergy Rhinol 2017 12 16;7(12):1135-1139. Epub 2017 Nov 16.

Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX.

Background: Ear symptoms are common among patients presenting to a rhinology clinic. Validated inventories are available for patient quality-of-life in sinonasal disease and Eustachian tube dysfunction (ETD). This study sought to determine the extent of ETD symptoms, using validated metrics, in a large population of patients presenting to a tertiary rhinology clinic. Read More

Am J Rhinol Allergy 2017 Nov;31(6):370-375

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Background: We previously presented that women with chronic rhinosinusitis (CRS) who elected endoscopic sinus surgery (ESS) have a higher symptom burden than men. Causes of these gender-based differences warranted further study.

Objectives: To study gender differences in another cohort of adult patients with CRS who underwent ESS and to compare key histopathologic and serologic features Methods: Patients with CRS who underwent ESS (from 2011 to 2014) with structured histopathology reports on surgical samples were studied. Read More