1,001 results match your criteria Allergic Fungal Sinusitis

IRVAN syndrome: A case report and a literature review.

Ann Med Surg (Lond) 2022 May 4;77:103725. Epub 2022 May 4.

Department of Ophthalmology, Zaid Al Sharity National Hospital, As'suwayda, Syrian Arab Republic.

Introduction And Importance: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is a rare retinal defect. It has a female predominance. The staging of IRVAN was defined depending on ocular criteria. Read More

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[Treatment experience of recurrent allergic fungal rhinosinusitis: a case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;57(5):612-614

Department of Otorhinolaryngology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

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Arerugi 2022 ;71(3):195-199

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine.

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Clinical Efficacy of Single Vidian Neurectomy in Chronic Rhinosinusitis with Nasal Polyps and Allergic Rhinitis.

J Coll Physicians Surg Pak 2022 May;32(5):618-622

Department of Otolaryngology-Head & Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China.

Objective: To investigate the clinical efficacy of single Vidian neurectomy (sVN) in the treatment of chronic rhinosinusitis with nasal polyps and allergic rhinitis (CRSwNP &AR).

Study Design: Descriptive study.   Place and Duration of Study: Otolaryngology-Head &Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, China, February 2016 to February 2019. Read More

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Management of Fungal Rhinosinusitis: Experience From a Tertiary Care Centre in North India.

Cureus 2022 Apr 4;14(4):e23826. Epub 2022 Apr 4.

Department of Otorhinolaryngology & Head and Neck Surgery (ENT-HNS), Hamdard Institute of Medical Sciences and Research, Hakeem Abdul Hameed Centenary Hospital, New Delhi, IND.

Introduction Fungal rhinosinusitis (FRS) has increased over the past few decades due to the rampant use of antibiotics, steroids, immunosuppressive drugs, increased incidence of HIV and uncontrolled diabetes. The current study reviews the types, clinical presentation, microbiology, histopathology and outcomes related to FRS in a tertiary care center in North India. Methods We retrospectively reviewed the clinical and follow-up records of patients diagnosed with FRS over three years. Read More

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Misdiagnosis of fungal infections of the orbit.

Can J Ophthalmol 2022 May 4. Epub 2022 May 4.

From the Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address:

Objective: To evaluate the accuracy of the initial diagnosis in the case of fungal infections of the orbit and identify factors that may influence patient outcomes.

Methods: An institutional review board-approved retrospective chart review was conducted across 2 large academic centres to identify cases of fungal infections involving the orbit from January 1, 1998, to November 15, 2019. Data collected included patient demographics, past medical history, examination findings, diagnosis, treatment, imaging, and outcomes. Read More

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[Presentation and management of allergic fungal rhinosinusitis in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Apr;36(4):247-252

Department of Otolaryngology Head and Neck Surgery,Children's Hospital Capital Institute of Pediatrics,Beijing,100020,China.

To assess the presentation of allergic fungal rhinosinusitis(AFRS) in children and the role of long-term comprehensive therapy of endoscopic surgery combined with drug therapy. The 3 children with AFRS were routinely examined by nasal endoscopy, CT scan, MRI scan and allergen detection before surgery, and mycological and histomathological examination were performed on the secretions in the sinus and the mucosa of the affected sinuses. All the 3 patients underwent endoscopic surgery, preoperative and postoperative treatment with oral and nasal corticosteroid, nasal irrigation, and individualized anti-allergy therapy and immunotherapy. Read More

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Dupilumab: An emerging therapy in allergic fungal rhinosinusitis.

World Allergy Organ J 2022 Mar 30;15(3):100638. Epub 2022 Mar 30.

Department of Ophthalmology, and Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Allergic fungal rhinosinusitis (AFRS) is a highly resistant disease and is challenging to treat. Patients with recurrent attacks of the disease despite surgical management can benefit from biologics as adjunct therapies. Dupilumab has shown promising endpoints in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). Read More

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'CT and CT image-based texture image analysis in radiological diagnostics of allergic fungal rhinosinusitis'.

Mycoses 2022 May 24;65(5):551-559. Epub 2022 Mar 24.

Clinic for Infectious and Tropical Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Background: This prospective study is focused on evaluating radiological properties of AFRS. We analysed specific CT features related to the presence of AFRS, as well as explored the possible usefulness of the texture image analysis (TIA) as an additional diagnostical parameter.

Methods: The CT images of maxillary sinuses of 37 adult patients diagnosed with chronic rhinosinusitis were analysed for homogeneity, high-attenuation areas, density of the soft tissue mass, bony wall thickness and density. Read More

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STAT6 Blockade Abrogates -Induced Eosinophilic Chronic Rhinosinusitis and Asthma, A Model of Unified Airway Disease.

Front Immunol 2022 23;13:818017. Epub 2022 Feb 23.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States.

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with , and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS. Read More

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The Endoscopic Management of Different Pediatric Frontal Sinus Pathologies.

Int J Otolaryngol 2022 10;2022:1078178. Epub 2022 Feb 10.

King Faisal University, Alahsa, Saudi Arabia.

Background: The paranasal sinuses in pediatrics can harbor a wide variety of pathologies. With the present literature being composed of case studies only, this entity is quite understudied.

Objectives: This article aims to study the clinical presentation, diagnosis, and endoscopic management of six different rare frontal sinus pathologies in pediatrics, which include extensive allergic fungal sinusitis, mucoceles, osteoma, superior sagittal sinus thrombosis, CSF leak, and subdural empyema. Read More

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February 2022

Daily Saline Nasal Douching for Chronic Allergic Rhinosinusitis: An Autobiographical Case Report.

Cureus 2022 Jan 12;14(1):e21153. Epub 2022 Jan 12.

Department of Orthopaedics, All India Institute of Medical Sciences, Bibinagar, Hyderabad, IND.

Chronic allergic rhinosinusitis is a debilitating condition in a group of susceptible individuals with multifactorial etiology. I present my case of suffering from chronic allergic rhinosinusitis for 25 years treated with multiple drugs and surgeries with no relief. Adjunctive daily saline nasal douching has provided significant relief for three years to date. Read More

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January 2022

Allergic Fungal Rhinosinusitis in Saudi Arabia: A Review of Recent Literature.

Cureus 2021 Dec 25;13(12):e20683. Epub 2021 Dec 25.

Department of Otolaryngology, College of Medicine, Majmaah University, Al-Majmaah, SAU.

Allergic fungal rhinosinusitis (AFRS) has been considered an enigma since it was first described four decades ago. Previous research has found that AFRS has multiple definitions and a poorly understood pathogenesis because it overlaps with other conditions and necessitates meticulous work and multiple diagnostic modalities to confirm the diagnosis. However, despite the expansion of medical and surgical treatments, recurrence still occurs. Read More

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December 2021

Orbital Complications of Chronic Rhinosinusitis: Two Years' Experience in a Tertiary Referral Hospital.

Ocul Immunol Inflamm 2022 Jan 20:1-6. Epub 2022 Jan 20.

Department of Ophthalmology, Faculty of Medicine, University of Tanta, Tanta, Egypt.

Purpose: To investigate the different clinical manifestations in Egyptian patients with orbital complications of rhinosinusitis (RS) according to the pathology within the paranasal sinuses.

Methods: The medical records of patients presented with chronic RS between August 2018 and December 2020 were retrospectively reviewed.

Results: This study included 64 patients: 28 patients with subperiosteal abscess (SPA), 10 with allergic fungal RS, 6 with isolated fungal RS, 6 with invasive fungal RS, and 14 with mucocele. Read More

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January 2022

Adenoidal bacterial biofilm in pediatric rhinosinusitis.

Rom J Morphol Embryol 2021 Apr-Jun;62(2):481-489

Department of ENT, Vasile Goldiş Western University of Arad, Romania; Department of Microbiology, University of Medicine and Pharmacy of Craiova, Romania;

The aim of the study was to observe, using scanning electron microscopy (SEM), the ratio of bacterial biofilm coverage of adenoidal tissue in children diagnosed with chronic rhinosinusitis (CR), compared to the ratio of adenoid bacterial biofilm coverage in children diagnosed with obstructive sleep apnea (OSA). We also performed histopathological and immunohistochemical tests to correlate the results with the images obtained from SEM. We estimated, using an image analysis program, the coverage ratio with bacterial biofilm on the surface of the lymphatic tissue. Read More

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January 2022

The role of fungus in the pathogenesis of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg 2022 Feb;30(1):58-62

Department of Otorhinolaryngology - Head and Neck Surgery, McGovern Medical School of the University of Texas Health Science Center at Houston.

Purpose Of Review: The etiologic role of fungi in chronic rhinosinusitis remains controversial. The purpose of this review is to further our understanding of molecular immunologic pathways activated by fungi and clinical trials of antifungals in severe subtypes of asthma and allergic fungal rhinosinusitis.

Recent Findings: Various fungal components such as protease and chitin are capable of eliciting a type 2 innate and adaptive immune response. Read More

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February 2022

Postoperative osteoneogenesis in patients with allergic fungal rhinosinusitis with skull base erosions.

Int Forum Allergy Rhinol 2021 Dec 15. Epub 2021 Dec 15.

Department of Otolaryngology - Head and Neck Surgery, Augusta University, Augusta, GA.

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December 2021

Treatment options for chronic rhinosinusitis with nasal polyps.

Dana V Wallace

Allergy Asthma Proc 2021 11;42(6):450-460

The management of chronic rhinosinusitis with nasal polyps (CRSwNP) is evolving, with an emphasis on treating the underlying type 2 inflammation. The objective was to summarize the updated evidence-based medical and surgical treatment recommendations for CRSwNP, including the position of biologics in the treatment algorithm. This review compared and contrasted the therapeutic recommendations presented by the European Position Paper on Rhinosinusitis and Nasal Polyps 2020 and the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis 2021. Read More

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November 2021

Demographic Variation in Chronic Rhinosinusitis by Subtype and Region: A Systematic Review.

Am J Rhinol Allergy 2022 May 26;36(3):367-377. Epub 2021 Nov 26.

2345Medical University of South Carolina, Charleston, South Carolina, USA.

Background: Chronic rhinosinusitis (CRS) describes a heterogenous group of diseases including CRS with (CRSwNP) or without nasal polyps (CRSsNP), aspirin-exacerbated respiratory disease (AERD), and allergic fungal rhinosinusitis (AFRS). It affects 10 to 15% of the US population and is more common in women and White patients. However, these estimates are based on survey and database studies with innate diagnostic inaccuracy. Read More

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Allergic fungal rhinosinusitis caused by Neoscytalidium dimidiatum: A case report: Allergic fungal rhinosinusitis due to Neoscytalidium dimidiatum.

J Mycol Med 2022 Mar 12;32(1):101212. Epub 2021 Oct 12.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Neoscytalidium dimidiatum is a rare dematiaceous fungus that was first described in 1916 as Dothiorella mangiferae. From the standpoint of epidemiology and therapy, early detection of fungal rhinosinusitis (FRS), the causative agents, and their associated risk factors can improve the therapeutic outcome and decrease the mortality rates among patients. In this study, we report a 34-year-old Iranian female patient with allergic bronchopulmonary aspergillosis (ABPA), who presented to our facility with an 8-year history of chronic fungal sinusitis, drug-resistant asthma, pneumonia, bronchitis, post-nasal discharge, nasal obstruction, nasal polyposis, and anemia. Read More

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Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota.

Allergy 2022 02 14;77(2):540-549. Epub 2021 Nov 14.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Recent studies have revealed that the nasal microbiota in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is profoundly altered and is correlated with systemic inflammation. However, little is known regarding whether the microbiota can be utilized to predict nasal polyp recurrence. This study is aimed to determine whether altered nasal microbiota constituents could be used as biomarkers to predict CRSwNP recurrence. Read More

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February 2022

A case report of rare fungal pathogens causing recurrent allergic fungal rhinosinusitis and literature review.

Ahmad Alroqi

Sci Prog 2021 10;104(4):368504211053512

Department of Otolaryngology-Head & Neck Surgery, 37850King Saud University, Saudi Arabia.

Allergic fungal rhinosinusitis has been well characterized clinically. We report about a patient diagnosed with allergic fungal rhinosinusitis. Nasal cultures revealed a rare fungal pathogen, . Read More

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October 2021

What is allergic fungal sinusitis: A call to action.

Int Forum Allergy Rhinol 2022 02 30;12(2):141-146. Epub 2021 Oct 30.

Department of Otorhinolaryngology-Head and Neck Surgery, McGovern Medical School of the University of Texas Health Science Center at Houston, Houston, Texas, USA.

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February 2022

Yardstick for the medical management of chronic rhinosinusitis.

Ann Allergy Asthma Immunol 2022 02 20;128(2):118-128. Epub 2021 Oct 20.

Division of Immunology-Allergy Section, Department of Internal Medicine, The University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

Chronic rhinosinusitis (CRS) is an inflammatory condition of the paranasal sinuses defined by classic symptoms, imaging findings, or endoscopic findings. There are a growing number of emerging pharmacologic therapies being evaluated to treat patients with CRS, some of which have gained indication status in the United States. There have not been updated treatment guidelines published in the United States however since 2014. Read More

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February 2022

Eosinophilic mucin chronic rhinosinusitis with orbital involvement: management strategies based on clinical presentation.

Indian J Ophthalmol Case Rep 2021 Jan-Mar;1(1):156-158. Epub 2020 Dec 31.

New York University, Department of Ophthalmology.

Allergic fungal sinusitis (AFS) and eosinophilic mucin chronic rhinosinusitis (EMCRS) are subtypes of a chronic rhinosinusitis with eosinophilia that have different diagnostic criteria but are phenotypically similar. Ophthalmic complications may be the presenting symptoms. Treatment of ophthalmic complications is typically directed at reducing the inflammatory burden in the sinuses and rarely requires direct surgical intervention. Read More

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December 2020

A Schizophyllum commune fungus ball in a lung cancer cavity: a case report.

BMC Infect Dis 2021 Oct 9;21(1):1052. Epub 2021 Oct 9.

Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chiba, 260-8673, Japan.

Background: Schizophyllum commune is a basidiomycete that lives in the environment and can cause infections, mainly those of the respiratory system. Although S. commune is increasingly reported as a cause of allergic bronchopulmonary mycosis and sinusitis, cases of fungal ball formation are extremely uncommon. Read More

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October 2021

Pediatric allergic fungal rhinosinusitis: optimizing outcomes.

Curr Opin Otolaryngol Head Neck Surg 2021 Dec;29(6):510-516

Department of Surgery-Otorhinolaryngology Head and Neck Surgery, Central Adelaide Local Health Network and the Department of Surgery, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.

Purpose Of Review: Allergic fungal rhinosinusitis (AFRS) is a debilitating condition for children. Despite there being several reviews on this topic in the adult population, there is a paucity of reviews of AFRS in the pediatric literature. This article reviews the recent evidence of pediatric AFRS with the aim to optimize outcomes of pediatric patients with this condition. Read More

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December 2021

Neutrophils Affect IL-33 Processing in Response to the Respiratory Allergen .

Front Immunol 2021 17;12:677848. Epub 2021 Aug 17.

Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium.

Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). The presence of neutrophils in the airways is often associated with severe airway inflammation, while their precise contribution to the severe inflammation is largely unknown. We aimed to study the role of neutrophils in BALB/c and C57BL/6 mice exposed to (). Read More

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October 2021

Severe asthma in Kuwait population: Phenotype-based approach.

Respir Med 2021 10 27;187:106586. Epub 2021 Aug 27.

Al-Rashed Allergy Center, Ministry of Health, Kuwait. Electronic address:

Background: There is increasing recognition of marked phenotypic heterogeneity within severe asthma patients.

Methods: Severe asthma patients on GINA step 4 or 5 treatment, followed up at Al-Rashed Allergy center Kuwait, were evaluated for: demographics (gender, age, age of asthma onset), comorbidities (allergic rhinitis (AR), chronic rhinosinusitis (CRS), chronic rhinosinusitis with nasal polyposis (CRSwNP), obesity), blood biomarkers (total serum Immunoglobulin E (IgE), peripheral eosinophils), and sensitization to inhalants allergens.

Results: A total of 169 patients were candidates for biological treatment. Read More

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October 2021

Allergic Fungal Sinusitis: Ophthalmic Complications Due to the COVID-19 Pandemic and the Potential of Telemedicine.

Cureus 2021 Jul 18;13(7):e16458. Epub 2021 Jul 18.

Ophthalmology, The University of Tennessee Health Science Center, Memphis, USA.

We report a case of a 26-year-old female who initially presented to an outside optometrist with complaints of proptosis and decreased visual acuity. Magnetic resonance imaging (MRI) obtained at that time was concerning for allergic fungal sinusitis. Unfortunately, the patient's referral to ophthalmology was delayed due to the coronavirus disease 2019 (COVID-19) pandemic. Read More

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