2,708 results match your criteria Alimentary pharmacology & therapeutics[Journal]


Kynurenic acid as the neglected ingredient of commercial baby formulas.

Sci Rep 2019 Apr 15;9(1):6108. Epub 2019 Apr 15.

Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, PL-20090, Lublin, Poland.

The global increase in resorting to artificial nutritional formulas replacing breastfeeding has been identified among the complex causes of the obesity epidemic in infants and children. One of the factors recently recognized to influence metabolism and weight gain is kynurenic acid (KYNA), an agonist of G protein-coupled receptor (GPR35). Therefore the aim of the study was to determine the concentration of KYNA in artificial nutritional formulas in comparison with its level in human breast milk and to evaluate developmental changes in rats exposed to KYNA enriched diet during the time of breastfeeding. Read More

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http://www.nature.com/articles/s41598-019-42646-4
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http://dx.doi.org/10.1038/s41598-019-42646-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465401PMC
April 2019
1 Read

[Study of lutein and zeaxanthin content in the diet with the assessment of the relationship between the level of alimentary intake of non-vitamin carotenoids and the density of the macular region of the retina at a young age].

Vopr Pitan 2018 13;87(5):20-26. Epub 2018 Sep 13.

I.M. Sechenov First Moscow State Medical University (Sechenov University).

Lutein and zeaxanthin are carotenoid pigments that affect the function of the visual analyzer. They selectively accumulate in the yellow spot of the retina, form macular pigment and determine the density of the retina macula. Lutein and zeaxanthin slow down the progression of age-related macular degeneration, a leading cause of senior-age blindness. Read More

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http://cyberdoi.ru/doi/10.24411/0042-8833-2018-10049
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http://dx.doi.org/10.24411/0042-8833-2018-10049DOI Listing
April 2019
4 Reads

Improved Modeling of Plutonium-DTPA Decorporation.

Radiat Res 2019 02 19;191(2):201-210. Epub 2018 Dec 19.

U.S. Transuranium and Uranium Registries, Washington State University, Richland, Washington 99354-4959.

Individuals with significant intakes of plutonium (Pu) are typically treated with chelating agents, such as the trisodium salt form of calcium diethylenetriaminepentaacetate (CaNa-DTPA, referred to hereafter as Ca-DTPA). Currently, there is no recommended approach for simultaneously modeling plutonium biokinetics during and after chelation therapy. In this study, an improved modeling system for plutonium decorporation was developed. Read More

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http://www.rrjournal.org/doi/10.1667/RR15188.1
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http://dx.doi.org/10.1667/RR15188.1DOI Listing
February 2019
14 Reads

Disease course of inflammatory bowel disease unclassified in a European population-based inception cohort: An Epi-IBD study.

J Gastroenterol Hepatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Gastroenterology, North Zealand Hospital, University of Copenhagen, Copenhagen, Denmark.

Background And Aim: A definitive diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) is not always possible, and a proportion of patients will be diagnosed as inflammatory bowel disease unclassified (IBDU). The aim of the study was to investigate the prognosis of patients initially diagnosed with IBDU and the disease course during the following 5 years.

Methods: The Epi-IBD study is a prospective population-based cohort of 1289 IBD patients diagnosed in centers across Europe. Read More

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http://doi.wiley.com/10.1111/jgh.14563
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http://dx.doi.org/10.1111/jgh.14563DOI Listing
December 2018
13 Reads

Silver effects on silkworm, Bombyx mori.

J Toxicol Sci 2018 ;43(12):697-709

School of Food and Biological Engineering, Jiangsu University, China.

Silver nanoparticles (Ag-NPs) are known as a noble metal, and owing to their exclusive properties, their use is widespread in consumer products and they are mostly incorporated into food packaging and food contact products. The aim of this work was to evaluate the effects of direct ingestion of Ag-NPs through food to assess their toxicity effects on the growth and development of silkworms at different concentrations (1 mg·L to 100 mg·L), in addition to the examination of the distribution of Ag-NPs in the silkworm body and midgut histopathological analysis. RNA sequencing was performed to investigate the transcriptomic responses to Ag-NPs exposure. Read More

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http://dx.doi.org/10.2131/jts.43.697DOI Listing
January 2019
4 Reads

The impact of a nutritional intervention based on egg white for phosphorus control in hemodialyis patients.

Nutr Metab Cardiovasc Dis 2019 01 28;29(1):45-50. Epub 2018 Sep 28.

Department of Neuroscience, Reproductive Sciences and Dentistry, Division of Pharmacology, Federico II University of Naples, Italy; Federico II University Hospital, Naples, Italy.

Background And Aims: Here we describe a dietary intervention for hyperphosphatemia in dialysis patients based on the partial replacement of meat and fish, which are one of the main sources of alimentary phosphorous, with egg white, a virtually phosphorous-free protein source. This intervention aims to reduce phosphorous intake without causing protein wasting.

Patients And Methods: As many as 23 hyperphosphatemic patients (15 male and 8 female, mean age 53. Read More

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http://dx.doi.org/10.1016/j.numecd.2018.09.010DOI Listing
January 2019
7 Reads

Biodegradable biliary stents preferable to plastic stent therapy in post-cholecystectomy bile leak and avoid second endoscopy.

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1376-1380. Epub 2018 Nov 5.

a Department of Gastroenterology and Alimentary Tract Surgery , Tampere University Hospital , Tampere , Finland.

Background: The treatment of post-cholecystectomy bile leak is endoscopic retrograde cholangiography (ERC) with plastic stent (PS) insertion combined with external drainage. Self-expanding biodegradable biliary stents (BDBS) have only recently become available.

Aim: The aim was to compare success rate, adverse events and costs of BDBS with PS in the treatment of post-cholecystectomy cystic duct leak Materials and methods: Patients recruited prospectively for treatment with BDBS during the period 2014-2017 were compared to a control group treated with PS in a non-randomized setting. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1518480DOI Listing
April 2019
22 Reads

Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-Alcoholic Steatohepatitis (NASH) Induced by "Junk Food": Evidence for Anti-Inflammatory Activity.

Nutrients 2018 Nov 1;10(11). Epub 2018 Nov 1.

Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy.

Wrong alimentary behaviors and so-called "junk food" are a driving force for the rising incidence of non-alcoholic fatty liver disease (NAFLD) among children and adults. The "junk food" toxicity can be studied in "cafeteria" (CAF) diet animal model. Young rats exposed to CAF diet become obese and rapidly develop NAFLD. Read More

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http://www.mdpi.com/2072-6643/10/11/1604
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http://dx.doi.org/10.3390/nu10111604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267059PMC
November 2018
12 Reads

Copper Metabolism of Newborns Is Adapted to Milk Ceruloplasmin as a Nutritive Source of Copper: Overview of the Current Data.

Nutrients 2018 Oct 30;10(11). Epub 2018 Oct 30.

Department of Physiology and Pharmacology, Des Moines University, Des Moines, IA 50312, USA.

Copper, which can potentially be a highly toxic agent, is an essential nutrient due to its role as a cofactor for cuproenzymes and its participation in signaling pathways. In mammals, the liver is a central organ that controls copper turnover throughout the body, including copper absorption, distribution, and excretion. In ontogenesis, there are two types of copper metabolism, embryonic and adult, which maintain the balance of copper in each of these periods of life, respectively. Read More

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http://dx.doi.org/10.3390/nu10111591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266612PMC
October 2018
1 Read

Long-term functional outcome after restorative proctocolectomy: a cross-sectional study.

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1245-1249. Epub 2018 Oct 22.

c School of Medicine , University of Tampere , Tampere , Finland.

Objective: Restorative proctocolectomy is the procedure of choice in the surgical treatment of ulcerative colitis. Functional outcome is the key result of surgery. The aim of this study was to evaluate the long term-functional outcome after the procedure. Read More

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http://dx.doi.org/10.1080/00365521.2018.1518479DOI Listing
April 2019
13 Reads

Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use.

Vaccine 2018 11 15;36(48):7257-7261. Epub 2018 Oct 15.

Department of Virology, Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic. Electronic address:

In tick-borne encephalitis (TBE) endemic areas, consumption of unpasteurized milk or milk products from grazing domestic ruminants (goats, cattle, and sheep) represents a risk of TBE virus (TBEV) infection for humans. In addition to vaccination of humans, human alimentary TBEV infections can be avoided by pasteurizing milk or by vaccination of the ruminants. However, there is presently no TBEV vaccine for veterinary use. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.10.034DOI Listing
November 2018
1 Read

Retraction: Randomised clinical trial: The clinical efficacy and safety of an alginate-antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China by J. Sun, C. Yang, H. Zhao, P. Zheng, J. Wilkinson, B. Ng, Y. Yuan. Aliment Pharmacol Ther. 2015;42:845-854.

Authors:

Aliment Pharmacol Ther 2018 Nov;48(9):1039

The above article from Alimentary Pharmacology & Therapeutics, published online on 31 July 2015 on Wiley Online Library (wileyonlinelibrary.com), and in Volume 42, pp. 845-854, has been retracted by agreement between the authors, J. Read More

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http://dx.doi.org/10.1111/apt.15018DOI Listing
November 2018

Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study.

J Crohns Colitis 2019 Feb;13(2):198-208

Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.

Background And Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort.

Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Read More

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjy154DOI Listing
February 2019
14 Reads

Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease.

Auton Neurosci 2019 Jan 18;216:63-71. Epub 2018 Sep 18.

Institute of Anatomy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address:

Diverticular disease (DD) is one of the most prevalent diseases of the large bowel. Lately, imbalance of neuro-muscular transmission has been recognized as a major etiological factor for DD. Neuronal calcitonin gene-related peptide (CGRP) is a potent gastrointestinal smooth muscle relaxant shown to have a widespread effect within the alimentary tract. Read More

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http://dx.doi.org/10.1016/j.autneu.2018.09.006DOI Listing
January 2019
1 Read

Ingestion of bedding material as a cause of acute copper sulfate poisoning in turkey poults.

Poult Sci 2019 Feb;98(2):707-711

Department of Pharmacology and Toxicology, National Veterinary Research Institute, Aleja Partyzantow 57, 24-100 Pulawy, Poland.

The article reports a case of acute copper sulfate (CuSO4) poisoning in 2-day-old turkeys. The first incidences were noticed 2 h after placing the animals in the poultry house, where turkeys were provided with wood shaving bedding. Post-mortem examination showed wood shavings present in gastric and intestinal contents and numerous lesions in the alimentary tract: dark green color of the koilin lining, and surface erosions, deep ulceration, and severe congestion of the gizzard. Read More

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http://dx.doi.org/10.3382/ps/pey430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376218PMC
February 2019
7 Reads

Bovine upper alimentary squamous cell carcinoma associated with bracken fern poisoning: Clinical-pathological aspects and etiopathogenesis of 100 cases.

PLoS One 2018 26;13(9):e0204656. Epub 2018 Sep 26.

Departamento de Patologia, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

Upper digestive tract (UDT) cancer is rare in cattle, however in Southern Brazil, the UDT squamous cell carcinomas (SCCs) are relatively common and have been associated with bracken fern consumption and the presence of papillomas. Although a theory of pathogenesis considers bovine papillomavirus type 4 (BPV-4) as a cofactor in the development of these SCCs, some aspects of the etiopathogenesis of this disease need to be more investigated. In fact, detection of BPV-4 in UDT papillomas is scarce in other regions of the world and has not been performed in Brazil. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204656PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157896PMC
March 2019
13 Reads

Microbial Biomarkers in Patients with Nonresponsive Celiac Disease.

Dig Dis Sci 2018 12 20;63(12):3434-3441. Epub 2018 Sep 20.

Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Arvo Ylpön katu 34, 33014, Tampere, Finland.

Background And Aims: In nonresponsive celiac disease (NRCD), the symptoms and duodenal damage persist despite a gluten-free diet. Celiac disease patients with persistent symptoms are found to have a dysbiotic microbiota. We thus hypothesized that increased seroreactivity to the serum gluten-sensitive microbial antibodies Saccharomyces cerevisiae (ASCA), Pseudomonas fluorescens-associated sequence (I2), and Bacteroides caccae TonB-linked outer membrane protein (OmpW) is associated with NRCD. Read More

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http://dx.doi.org/10.1007/s10620-018-5285-zDOI Listing
December 2018
1 Read

Case report on alimentary tract hemorrhage and liver injury after therapy with oseltamivir: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12497

The First Hospital of Jilin University.

Rationale: Oseltamivir-induced alimentary tract hemorrhage and liver injury are rarely reported in children and adult individuals. In this study, we described the clinical features and outcomes of oseltamivir-induced alimentary tract hemorrhage and liver injury in a child.

Patient Concerns: Here, we present a case of a 6-year-old Asian boy with hematemesis and elevated alanine aminotransferase (ALT) (80 U/L) and aspartate aminotransferase (AST) (69 U/L) levels on day 2 of oseltamivir administration. Read More

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http://dx.doi.org/10.1097/MD.0000000000012497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160054PMC
September 2018
1 Read

Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment.

J Physiol Biochem 2018 Nov 19;74(4):647-654. Epub 2018 Sep 19.

Institut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048, Université de Toulouse, UPS, Toulouse, France.

To fight against metabolic disorders such as insulin resistance, new alimentary behaviors are developed. For instance, hyperproteined, gluten-free, or collagen-enriched diets could be preconized in order to reduce the consequences of obesity. In this aim, this study evaluates the potential effects of warm sea fish collagen peptides (Naticol®) on representative metabolic and inflammatory parameters. Read More

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http://dx.doi.org/10.1007/s13105-018-0650-0DOI Listing
November 2018
8 Reads

Preventative laparoscopic repair of Petersen's space following gastric bypass surgery reduces the incidence of Petersen's hernia: a comparative study.

Hernia 2018 12 28;22(6):1077-1081. Epub 2018 Aug 28.

Department of Medicine, Universidad El Bosque, Bogotá, Colombia.

Introduction: Internal hernias (IH) are late complications of bariatric surgery, specifically gastric bypass and manifest with diffuse abdominal pain and/or intestinal obstruction. They have a low incidence, however, are increasingly common in patients undergoing laparoscopic gastric bypass (LGBP). Petersen's internal hernia is one of the most frequent internal hernias following Bariatric surgery. Read More

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http://dx.doi.org/10.1007/s10029-018-1814-0DOI Listing
December 2018
10 Reads

Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study.

Eur J Gastroenterol Hepatol 2018 11;30(11):1297-1303

Department of Gastroenterology, North Zealand University Hospital, Roskilde, Denmark.

Background: Serum vitamin D level is commonly low in patients with inflammatory bowel disease (IBD). Although there is a growing body of evidence that links low vitamin D level to certain aspects of IBD such as disease activity and quality of life, data on its prevalence and how it varies across disease phenotype, smoking status and treatment groups are still missing.

Materials And Methods: Patients diagnosed with IBD between 2010 and 2011 were recruited. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001238DOI Listing
November 2018
17 Reads

Insects as sources of iron and zinc in human nutrition.

Nutr Res Rev 2018 12 23;31(2):248-255. Epub 2018 Jul 23.

2Laboratory of Entomology,Wageningen University and Research,PO Box 16,6700 AA Wageningen,The Netherlands.

Dietary deficiencies in Fe and Zn are globally widespread, causing serious health problems such as anaemia, poor pregnancy outcomes, increased risk of morbidity and mortality, stunted growth and impaired physical and cognitive development. Edible insects, of which a diversity of over 2000 species is available, are dietary components for about 2 billion individuals and are a valuable source of animal protein. In the present paper, we review the available information on Fe and Zn in edible insects and their potential as a source of these micronutrients for the rapidly growing human population. Read More

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http://dx.doi.org/10.1017/S0954422418000094DOI Listing
December 2018
12 Reads

Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists.

FASEB J 2019 Jan 18;33(1):518-531. Epub 2018 Jul 18.

Alimentary Pharmabiotic Centre (APC) Microbiome Ireland, University College Cork, Cork, Ireland.

The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] represents a promising pharmacologic target for the treatment of metabolic disorders, including obesity and cachexia, via central appetite modulation. The GHSR-1a has a complex pharmacology, highlighted by G-protein-dependent and -independent downstream signaling pathways and high basal constitutive activity. The functional selectivity and signaling bias of many GHSR-1a-specific ligands has not been fully characterized. Read More

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http://dx.doi.org/10.1096/fj.201800655RDOI Listing
January 2019
8 Reads

Analysis of risk factors and classification of aortic fistula after esophagectomy.

J Surg Res 2018 09 10;229:316-323. Epub 2018 May 10.

Department of Thoracic Surgery of Xiangya Hospital Central South University, Changsha, China. Electronic address:

Background: Aortic fistula after esophagectomy is a rare and serious complication. The aims of this study were to describe the causes of and classify the fistulas.

Materials And Methods: Between January 2008 and December 2017, a total of 1018 patients underwent esophageal resection, mainly for esophageal cancer; aortic fistula after esophagectomy was diagnosed in four patients. Read More

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http://dx.doi.org/10.1016/j.jss.2018.04.020DOI Listing
September 2018
18 Reads

Off-Label Use of Drugs and Adverse Drug Reactions in Pediatric Units: A Prospective, Multicenter Study.

Curr Drug Saf 2018 ;13(3):200-207

Regional Pharmacovigilance Centre of Catania, Unit of Pharmacology - A.O.U. Policlinico - Vittorio Emanuele, Catania, Italy.

Background: Given the growing use of off-label in pediatric practice, there is a growing interest on pharmacovigilance programs monitoring the occurrence of adverse drug reactions related to off-label drug prescription in childhood.

Patients And Methods: The results of a one-year program of pharmacovigilance issued in the Sicilian Region, Italy, are herein presented. The study involved 6 pediatric and neonatal centres and prospectively reviewed the prescriptions of 5,060 patients, who were stratified for age (newborn, infant, children, adolescents). Read More

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http://www.eurekaselect.com/163095/article
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http://dx.doi.org/10.2174/1574886313666180619120406DOI Listing
January 2019
19 Reads

Endoscopic management of primary sclerosing cholangitis.

Expert Rev Gastroenterol Hepatol 2018 Jul 18;12(7):693-703. Epub 2018 Jun 18.

b Division of Gastroenterology and Hepatology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

Introduction: Primary sclerosing cholangitis (PSC) is a rare but clinically important cholestatic liver disease. Histopathologically and cholangiographically, PSC is characterized by intra- and/or extra-hepatic bile duct inflammation and fibro-obliteration, which ultimately leads to biliary cirrhosis and related sequelae, including development of hepatobiliary and colorectal carcinomata. PSC can be diagnosed at essentially any age and carries a median survival of 15-20 years, regardless of age at diagnosis, and is a foremost risk factor for cholangiocarcinoma. Read More

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http://dx.doi.org/10.1080/17474124.2018.1483719DOI Listing
July 2018
3 Reads

Neuropathy by folic acid supplementation in a patient with anaemia and an untreated cobalamin deficiency: a case report.

Clin Obes 2018 Aug 31;8(4):300-304. Epub 2018 May 31.

Obesity Center, Catharina Hospital, Eindhoven, The Netherlands.

The rising rates of bariatric surgery (BS) are accompanied by neurological complications related to nutrient deficiencies. One of the risk factors for neurological complications in BS patients is poor vitamin and mineral supplementation. Prevention, diagnosis and treatment of these disorders are necessary parts of lifelong care after BS. Read More

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http://dx.doi.org/10.1111/cob.12254DOI Listing
August 2018
5 Reads

Parameters affecting the exposure to furfuryl alcohol from coffee.

Food Chem Toxicol 2018 Aug 26;118:473-479. Epub 2018 May 26.

Institute of Biochemistry, Graz University of Technology, Petersgasse 10-12/II, 8010, Graz, Austria.

Recently, furfuryl alcohol (FFA) was labelled a human potential carcinogen (group 2B) by the International Agency for Research on Cancer. Its alimentary exposure is mostly from coffee since in any other foods the concentrations are significantly lower. The various storage conditions of roasted coffee, the different brewing techniques applied and the bioaccessibility after ingestion are potential parameters that might alter the exposure to FFA from coffee. Read More

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http://dx.doi.org/10.1016/j.fct.2018.05.055DOI Listing
August 2018
1 Read

Bovine glycomacropeptide promotes the growth of Bifidobacterium longum ssp. infantis and modulates its gene expression.

J Dairy Sci 2018 Aug 24;101(8):6730-6741. Epub 2018 May 24.

Teagasc Food Research Centre, Moorepark, Fermoy, P61C996, Co. Cork, Ireland. Electronic address:

Bovine milk glycomacropeptide (GMP) is derived from κ-casein, with exclusively o-linked glycosylation. Glycomacropeptide promoted the growth of Bifidobacterium longum ssp. infantis in a concentration-dependent manner, and this activity was lost following periodate treatment of the GMP (GMP-P), which disables biological recognition of the conjugated oligosaccharides. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302183051
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http://dx.doi.org/10.3168/jds.2018-14499DOI Listing
August 2018
5 Reads

The clinical importance of changes in Treg and Th17 lymphocyte subsets in splenectomized patients after spleen injury.

Adv Clin Exp Med 2018 Jul;27(7):979-986

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Poland.

Background: Splenectomized patients are more prone to bacterial infections due to their immunocompromised status. Little is known about the role of T helper 17 (Th17) and T regulatory cells (Treg) in the immune system of patients after the removal of the spleen.

Objectives: The aim of the present study was to analyze possible changes in CD4+ lymphocyte T subsets, especially Treg and Th17, in patients who had undergone splenectomy. Read More

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http://dx.doi.org/10.17219/acem/73734DOI Listing
July 2018
4 Reads

A systematic review of biodegradable biliary stents: promising biocompatibility without stent removal.

Eur J Gastroenterol Hepatol 2018 08;30(8):813-818

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital.

Biodegradable self-expanding stents are an emerging alternative to standard biliary stents as the development of endoscopic insertion devices advances. The aim was to systematically review the existing literature on biodegradable biliary stents. In-vivo studies on the use of biodegradable stents in the biliary duct were systematically reviewed from 1990 to 2017. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001167DOI Listing
August 2018
3 Reads

Gastrointestinal stromal tumors: A multidisciplinary challenge.

World J Gastroenterol 2018 May;24(18):1925-1941

Department of General and Digestive Surgery, Reina Sofia University Hospital, Avda. Menéndez Pidal s/n, Cordoba 14004, Spain.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Read More

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http://dx.doi.org/10.3748/wjg.v24.i18.1925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949708PMC
May 2018
10 Reads

The Gamma-Aminobutyric Acid B Receptor in Depression and Reward.

Biol Psychiatry 2018 Jun 22;83(11):963-976. Epub 2018 Feb 22.

Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.

The metabotropic gamma-aminobutyric acid B (GABA) receptor was the first described obligate G protein-coupled receptor heterodimer and continues to set the stage for discoveries in G protein-coupled receptor signaling complexity. In this review, dedicated to the life and work of Athina Markou, we explore the role of GABA receptors in depression, reward, and the convergence of these domains in anhedonia, a shared symptom of major depressive disorder and withdrawal from drugs of abuse. GABA receptor expression and function are enhanced by antidepressants and reduced in animal models of depression. Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.02.006DOI Listing
June 2018
3 Reads

Multi-level toxicity assessment of engineered cellulose nanofibrils in Daphnia magna.

Nanotoxicology 2018 08 6;12(6):509-521. Epub 2018 May 6.

a Department of Environmental Science and Analytical Chemistry , Stockholm University , Stockholm , Sweden.

Cellulose nanofibril (CNF)-based materials are increasingly used in industrial and commercial applications. However, the impacts of CNF on aquatic life are poorly understood, and there are concerns regarding their potential toxicity. Using a combination of standard ecotoxicological tests and feeding experiments, we assessed the effects of CNF exposure (0. Read More

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http://dx.doi.org/10.1080/17435390.2018.1464229DOI Listing
August 2018
4 Reads

Exopolysaccharide from Bifidobacterium longum subsp. longum 35624™ modulates murine allergic airway responses.

Benef Microbes 2018 Sep 4;9(5):761-773. Epub 2018 May 4.

1 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zürich, Obere Strasse 22, 7270 Davos, Switzerland.

Interactions between the host and the microbiota are thought to significantly influence immunological tolerance mechanisms at mucosal sites. We recently described that the loss of an exopolysaccharide (EPS) from Bifidobacterium longum 35624™ eliminated its protective effects in colitis and respiratory allergy murine models. Our goal was to investigate the immune response to purified EPS from B. Read More

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http://dx.doi.org/10.3920/BM2017.0180DOI Listing
September 2018
5 Reads

A comprehensive review on regulatory effects of crocin on ischemia/reperfusion injury in multiple organs.

Biomed Pharmacother 2018 Mar 20;99:664-670. Epub 2018 Feb 20.

Behbahan Faculty of Medical Sciences, Behbahan, Iran.

Ischemia-reperfusion (I/R) injury affects o-dependent organs including liver, kidneys, heart, brain, and intestine. I/R injury is described as the cellular injury in an organ caused by ischemia and then further aggravated during the reperfusion due to intracellular alterations. It is a process that happens in clinical settings such as organ transplantation, reperfusion after thrombolytic therapy, and coronary angioplasty. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.01.113DOI Listing
March 2018
3 Reads

Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line.

Int J Radiat Biol 2018 06 30;94(6):607-618. Epub 2018 Apr 30.

a Department of Morphological Sciences , University of Santiago de Compostela , Santiago de Compostela , Spain.

Purpose: The aim of this study was to determine whether exposure to radiation from single or multiple radio-frequency (RF) signals at 900 and 2450 MHz would induce effects in the RAW 264.7 cell line.

Materials And Methods: Cell cultures were exposed to single or combined RF for 4, 24, 48, or 72 h in a GTEM electromagnetic test chamber. Read More

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http://dx.doi.org/10.1080/09553002.2018.1465610DOI Listing
June 2018
5 Reads

Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help.

Pharmacol Res 2018 06 5;132:21-32. Epub 2018 Apr 5.

Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid 28049, Spain. Electronic address:

The possibility that diet-derived miRNAs survive the gastrointestinal tract and exert biological effects in target cells is triggering considerable research in the potential abilities of alimentary preventive and therapeutic approaches. Many validation attempts have been carried out and investigators disagree on several issues. The barriers exogenous RNAs must surpass are harsh and adequate copies must reach target cells for biological actions to be carried out. Read More

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http://dx.doi.org/10.1016/j.phrs.2018.04.003DOI Listing
June 2018
2 Reads

Fecal microbiota in the female prairie vole (Microtus ochrogaster).

PLoS One 2018 26;13(3):e0190648. Epub 2018 Mar 26.

Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma, United States of America.

We examined the fecal microbiota of female prairie voles. This species is socially and, likely, sexually monogamous, and thus serves as a valuable model in which to examine the interaction between the microbiota-gut-brain axis and social behavior. At present, little is known about the gastrointestinal microbiota of prairie voles; therefore, we performed a first characterization of the fecal microbiota using 16S rRNA gene amplicon sequencing. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190648PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868765PMC
June 2018
5 Reads

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome.

Lab Invest 2018 Oct 23;98(10):1300-1310. Epub 2018 Mar 23.

Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

High-fat meal (HFM) consumption can produce acute lipemia and trigger myocardial infarction in patients with atherosclerosis, but the mechanisms are poorly understood. Erythrocytes (red blood cells, RBCs) intimately interact with inflammatory cells and blood vessels and play a complex role in regulating vascular function. Chronic high-fat feeding in mice induces pathological RBC remodeling, suggesting a novel link between HFM, RBCs, and vascular dysfunction. Read More

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http://dx.doi.org/10.1038/s41374-018-0038-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342280PMC
October 2018
17 Reads
3.680 Impact Factor

Protein-Amino Acid Metabolism Disarrangements: The Hidden Enemy of Chronic Age-Related Conditions.

Nutrients 2018 Mar 22;10(4). Epub 2018 Mar 22.

Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.

Proteins are macro-molecules crucial for cell life, which are made up of amino acids (AAs). In healthy people, protein synthesis and degradation are well balanced. However, in the presence of hypercatabolic stimulation (i. Read More

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http://dx.doi.org/10.3390/nu10040391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946176PMC
March 2018
2 Reads

Outcomes of primary anal sphincter repair after obstetric injury and evaluation of a novel three-choice assessment.

Tech Coloproctol 2018 03 15;22(3):209-214. Epub 2018 Mar 15.

Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

Background: The aim of the present study was to evaluate the subjective outcome of primary repair of obstetric anal sphincter injury (OASIS) at 6 months, the factors associated with the symptoms of anal incontinence (AI), and the role of a simple survey consisting in one question with three answer choices, combined with the Wexner incontinence score for the assessment of this patient population.

Methods: A retrospective cohort study was conducted on patients with third- or fourth-degree OASIS operated on between January 2007 and December 2013 inclusive at Tampere University Hospital, Finland. At 6 months, the patients were asked to report their Wexner's score as well as the three-choice assessment regarding AI symptoms. Read More

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http://dx.doi.org/10.1007/s10151-018-1770-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862944PMC

Newly identified colistin resistance genes, mcr-4 and mcr-5, from upper and lower alimentary tract of pigs and poultry in China.

PLoS One 2018 14;13(3):e0193957. Epub 2018 Mar 14.

College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.

Antimicrobial resistance against colistin has emerged worldwide threatening the efficacy of one of the last-resort antimicrobials used for the treatment of Enterobacteriaceae. To investigate the presence of the recently identified colistin resistance genes (mcr-4, mcr-5) in China, we established PCRs to detect mcr-4 and mcr-5 on 213 anal and 1,339 nasal swabs from apparently healthy pigs (n = 1,454) in nine provinces, and 1,696 cloacal and 1,647 oropharyngeal samples from poultry (n = 1,836) at live-bird markets in 24 provinces of China. The prevalence of the mcr-4 in swine swabs (41. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193957PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851611PMC
June 2018
15 Reads

Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome.

Int J Mol Sci 2018 Mar 10;19(3). Epub 2018 Mar 10.

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, Hungary.

Fenugreek is a common herb possessing several bioactive components including diosgenin. Here, dietary fenugreek seed flour and diosgenin were evaluated on a model of endothelium-dependent vasorelaxation by abdominal aortas isolated from rats receiving high-fat, high-sugar diet (HFHSD). 60 male Wistar rats were randomized into six groups: (i) negative control getting conventional rat feed regimen; (ii) positive control receiving HFHSD; (iii) a test group fed 2 g/kg bw/day fenugreek seed flour (containing 10 mg/kg bw/day diosgenin) + HFHSD; (iv) three test groups fed 1, 10 and 50 mg/kg bw/day diosgenin + HFHSD. Read More

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http://dx.doi.org/10.3390/ijms19030798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877659PMC
March 2018
11 Reads

Endoluminal vacuum-assisted therapy as treatment for anastomotic leak after ileal pouch-anal anastomosis: a pilot study.

Tech Coloproctol 2018 03 3;22(3):223-229. Epub 2018 Mar 3.

Surgery of the Alimentary Tract, Department of Medical and Surgical Sciences, Sant'Orsola - Malpighi Hospital, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

Background: Anastomotic leak after ileal pouch-anal anastomosis (IPAA) could lead to poor functional results and failure of the pouch. The aim of the present study was to analyze the outcomes of the vacuum-assisted closure therapy as the unique treatment for anastomotic leaks following IPAA without any additional surgical operations.

Methods: Consecutive patients with anastomotic leak after IPAA treated at our institution between March 2016 and March 2017 were prospectively enrolled. Read More

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http://dx.doi.org/10.1007/s10151-018-1762-9DOI Listing
March 2018
4 Reads

Medication wasted - Contents and costs of medicines ending up in household garbage.

Res Social Adm Pharm 2018 12 10;14(12):1140-1146. Epub 2018 Feb 10.

WHO Collaborating Centre for Pharmaceutical Pricing and Reimbursement Policies, Pharmacoeconomics Department, Gesundheit Österreich GmbH (Austrian Public Health Institute), Vienna, Austria; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Background: Despite potentially considerable implications for public health, the environment and public funds, medicine waste is an under-researched topic. This study aims to analyse medicines drawn from household garbage in Vienna (Austria) and to assess possible financial implications for public payers.

Methods: Four pharmaceutical waste samples collected by the Vienna Municipal Waste Department between April 2015 and January 2016 were investigated with regard to their content. Read More

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http://dx.doi.org/10.1016/j.sapharm.2018.02.002DOI Listing
December 2018
2 Reads

Limonene: Aroma of innovation in health and disease.

Chem Biol Interact 2018 Mar 7;283:97-106. Epub 2018 Feb 7.

São Paulo State University (UNESP), Institute of Biosciences, Department of Morphology, Botucatu, Brazil. Electronic address:

Natural products obtained in dietary components may aid the prevention and treatment of a variety of diseases. Reports in the scientific literature have demonstrated that the consumption of terpenes is a successful alternative in the treatment of several diseases, triggering beneficial biological effects in clinical and preclinical studies. The monoterpene limonene is largely used in alimentary items, cleaning products, and it is one of the most frequent fragrances used in cosmetics formulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00092797173104
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http://dx.doi.org/10.1016/j.cbi.2018.02.007DOI Listing
March 2018
1 Read

Association between use of phthalate-containing medication and semen quality among men in couples referred for assisted reproduction.

Hum Reprod 2018 03;33(3):503-511

Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, 5000 Odense C, Denmark.

Study Question: Does phthalate exposure from prescription drugs affect semen quality?

Summary Answer: Exposure to phthalate-containing drugs is associated with poor semen quality.

What Is Known Already: Phthalates and their metabolites have been shown to disrupt the hormone signalling in animal studies. One study has shown associations between medicinal phthalate exposure and poor semen quality, suggesting similar effects in humans. Read More

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http://dx.doi.org/10.1093/humrep/dey009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454815PMC
March 2018
4 Reads

Long-term quality of life after esophagectomy with gastric pull-up.

J Surg Oncol 2018 Apr 6;117(5):970-976. Epub 2018 Feb 6.

Surgical Oncology Unit, Veneto Institute of Oncology IOV IRCCS, Padua, Italy.

Background And Objectives: Data on long-term health-related quality of life (HRQL) after esophagectomy for cancer show contradictory results. The aim was to analyze long-term HRQL at 3 or more years after esophagectomy.

Methods: Survivors were identified among patients who had undergone esophagectomy during 2007-2013 using the local clinic database. Read More

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http://dx.doi.org/10.1002/jso.24995DOI Listing
April 2018
6 Reads
3.244 Impact Factor

Importance of maternal diet in the training of the infant's immune system during gestation and lactation.

Crit Rev Food Sci Nutr 2018 Feb 2:1-9. Epub 2018 Feb 2.

c Department of Neonatology , Wroclaw Medical University , Wroclaw , Poland.

Latest forecasts predict that half of the European population will be allergic within the coming 15 years, with food allergies contributing substantially to the total burden; preventive measures are urgently needed. Unfortunately, all attempted alimentary strategies for primary prevention of allergic diseases through allergen avoidance so far have failed. This also holds true for the prevention of food allergies in breastfed infants by the common practice of excluding certain foods with allergenic potential from the maternal diet. Read More

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http://dx.doi.org/10.1080/10408398.2017.1405907DOI Listing
February 2018
2 Reads