2,816 results match your criteria Alimentary pharmacology & therapeutics[Journal]


Optimized Ellagic Acid-Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.

Biomolecules 2020 Jul 6;10(7). Epub 2020 Jul 6.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1-3 w/v %), EA concentration (X2, 1-3 w/v %) and the dropping time (X3, 10-30 min). Read More

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http://dx.doi.org/10.3390/biom10071006DOI Listing

COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance.

Authors:
B Robson

Comput Biol Med 2020 06 11;121:103749. Epub 2020 Apr 11.

Ingine Inc. Cleveland Ohio USA, The Dirac Foundation, Oxfordshire, UK. Electronic address:

This paper continues a recent study of the spike protein sequence of the COVID-19 virus (SARS-CoV-2). It is also in part an introductory review to relevant computational techniques for tackling viral threats, using COVID-19 as an example. Q-UEL tools for facilitating access to knowledge and bioinformatics tools were again used for efficiency, but the focus in this paper is even more on the virus. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2020.103749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151553PMC

Insulin Management for Type 1 Diabetic Patients During Social Alcohol Consumption: The SPRITZ Study.

Curr Diabetes Rev 2020 ;16(6):619-627

Endocrine Unit, Diabetes Regional Centre, ASST Bergamo Ovest, Treviglio (Bg), Italy.

Background: There is no data available on the best insulin treatment to counteract the effects of glucose excursions due to a moderate alcohol intake associated with portions of slight fat and protein-containing food, as often the case during social happenings or "happy hours".

Introduction: This study analyzes the glycemic control and quality of life in 8 adult type 1 diabetic (T1D) patients on insulin-pump therapy which were invited to consume a traditional Italian aperitif ("Spritz" and chips).

Methods: Patients consumed Spritz aperitif twice: using their habitual bolus, based on carbohydrates (CHO) counting (V1), or with a personalized, advanced bolus (V2) calculated from insulin/Kcal derived from Fats and Proteins (FPU). Read More

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http://dx.doi.org/10.2174/1573399815666190507121332DOI Listing

Primary care faecal calprotectin testing in children with suspected inflammatory bowel disease: a diagnostic accuracy study.

Arch Dis Child 2020 May 18. Epub 2020 May 18.

Gastroenterology, Royal Devon and Exeter Hospital, Exeter, UK

Objective: To determine the diagnostic accuracy of calprotectin to diagnose inflammatory bowel disease (IBD) in children in whom general practitioners (GPs) suspected IBD.

Design: Prospective observational cohort study of a new calprotectin-based primary care referral pathway.

Setting: 48 GP practices and gastroenterology secondary care services at the Royal Devon and Exeter NHS Foundation Trust in the South-West of England, UK. Read More

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http://dx.doi.org/10.1136/archdischild-2019-317823DOI Listing

Spinosad application in an apple orchard affects both the abundance of the spider Araneus diadematus and its web construction behaviour.

Ecotoxicology 2020 May 9;29(4):389-397. Epub 2020 Apr 9.

CNRS, Faculty of Sciences and Technologies, UR AFPA, University of Lorraine, Bd Des Aiguillettes, B.P. 236, 54506, Vandoeuvre les Nancy - Cedex 09, France.

The principles of organic production are based on the respect of ecological processes including the promotion of natural enemies to control pests. However, as a last resort, some natural pesticides can be applied such as the pesticide spinosad. This neurotoxic insecticide is now widely used even in non-organic production systems. Read More

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http://dx.doi.org/10.1007/s10646-020-02179-3DOI Listing

The Efficacy and Safety of Modified Docetaxel, Cisplatin, and 5-Fluorouracil Vs. Epirubicin, Oxaliplatin, and Capecitabine Regimen in the Advanced Gastric Cancer: A Randomized Controlled Clinical Trial.

Asian Pac J Cancer Prev 2020 Mar 1;21(3):727-732. Epub 2020 Mar 1.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: One of the major challenges of advanced gastric cancer treatment is the lack of a standard regimen for patients. However, several clinical trials have shown that modified docetaxel, cisplatin, and 5-fluorouracil (m-DCF) and epirubicin, oxaliplatin, and capecitabine (EOX) regimens are superior to other regimens.

Methods: This randomized, single-center clinical trial was performed on 40 patients with advanced gastric cancer. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.3.727DOI Listing

Health-care costs of inflammatory bowel disease in a pan-European, community-based, inception cohort during 5 years of follow-up: a population-based study.

Lancet Gastroenterol Hepatol 2020 May 13;5(5):454-464. Epub 2020 Feb 13.

Department of Internal Medicine, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Inflammatory bowel disease (IBD) places a significant burden on health-care systems because of its chronicity and need for expensive therapies and surgery. With increasing use of biological therapies, contemporary data on IBD health-care costs are important for those responsible for allocating resources in Europe. To our knowledge, no prospective long-term analysis of the health-care costs of patients with IBD in the era of biologicals has been done in Europe. Read More

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http://dx.doi.org/10.1016/S2468-1253(20)30012-1DOI Listing

Omega-3 Self-Nanoemulsion Role in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats.

Pharmaceutics 2020 Feb 7;12(2). Epub 2020 Feb 7.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Peptic ulcer disease is an injury of the alimentary tract that leads to a mucosal defect reaching the submucosa. This study aimed to formulate and optimize omega-3 oil as a self-nanoemulsifying drug delivery system (SNEDDS) to achieve oil dispersion in the nano-range in the stomach to augment omega-3 oil gastric ulcer protection efficacy. Three SNEDDS components were selected as the design factors: the concentrations of the oil omega-3 (X1, 10-30%), the surfactant tween 20 and Kolliphor mixture (X2, 20-40%), and the cosurfactant transcutol (X3, 40-60%). Read More

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http://dx.doi.org/10.3390/pharmaceutics12020140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076357PMC
February 2020

Factors associated with workarounds in barcode-assisted medication administration in hospitals.

J Clin Nurs 2020 Jul 28;29(13-14):2239-2250. Epub 2020 Feb 28.

Department Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands.

Aims And Objectives: To identify that workarounds (defined as "informal temporary practices for handling exceptions to normal procedures or workflow") by nurses using information technology potentially compromise medication safety. Therefore, we aimed to identify potential risk factors associated with workarounds performed by nurses in Barcode-assisted Medication Administration in hospitals.

Background: Medication errors occur during the prescribing, distribution and administration of medication. Read More

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http://dx.doi.org/10.1111/jocn.15217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328795PMC

Effect of Sodium Cromoglycate on Acetic Acid-induced Ulcerative Colitis in Mice.

Korean J Gastroenterol 2020 01;75(1):39-45

Department of Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background/aims: Ulcerative colitis (UC) is a type of inflammatory bowel disease that mainly involves the colon. Thus far, glucocorticoids and amino-salicylate have been the main treatment.

Methods: To assess drugs with fewer side effects, this study evaluated the effects of sodium cromoglycate (SCG) on acetic acid-induced UC in rats. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.1.39DOI Listing
January 2020

Antifungal effects of statins.

Pharmacol Ther 2020 04 15;208:107483. Epub 2020 Jan 15.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Fungal infections are estimated to be responsible for 1.5 million deaths annually. Global anti-microbial resistance is also observed for fungal pathogens, and scientists are looking for new antifungal agents to address this challenge. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107483DOI Listing

[Biochemical markers of the functional state of liver in rats fed diets with different protein and sucrose content].

Vopr Pitan 2019;88(6):61-67. Epub 2019 Nov 19.

Yuriy Fedkovych Chernivtsi National University, Chernivtsi, Ukraine.

The study of mechanisms of the metabolic disorders in conditions of deficiency or excess of individual nutrients in the diet is a live issue. The influence of the simultaneous excess sucrose intake and protein deficiency in the diet on the functional state of the liver remains poorly understood. of the research was to study the rate of generation of the superoxide radicals, the content of triglycerides and glycogen in the liver, as well as the activity of enzymatic markers of the liver state in rats fed diets with different protein and sucrose content. Read More

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http://dx.doi.org/10.24411/0042-8833-2019-10065DOI Listing

Impact of Alpha-Lipoic Acid Chronic Discontinuous Treatment in Cardiometabolic Disorders and Oxidative Stress Induced by Fructose Intake in Rats.

Antioxidants (Basel) 2019 Dec 11;8(12). Epub 2019 Dec 11.

Department of Medical Biochemistry, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.

Insulin resistance (IR) and cardiometabolic disorders are the main consequences of today's alimentary behavior. This study evaluates the effects of a chronic-discontinuous treatment with alpha-lipoic acid (AL), an antioxidant substance that improves glycemic control associated with diabetes mellitus, on metabolic disorders and plasma oxidative stress induced by fructose intake, in rats. Sprague-Dawley rats (48 animals) were randomized into two series ( = 24): rats fed with standard chow or with standard chow supplemented with 60% fructose. Read More

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http://dx.doi.org/10.3390/antiox8120636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943500PMC
December 2019

Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift.

Int J Biochem Cell Biol 2020 02 9;119:105665. Epub 2019 Dec 9.

The Department of Neurochemistry, Palladin Institute of Biochemistry, NAS of Ukraine, 9, Leontovycha Street, Kyiv, 01030, Ukraine. Electronic address:

Vitamin D is among the major neurosteroids whose role in developing and adult brain is intensively studied now. Its active form 1,25(OH)D regulates the expression and functioning of a range of brain-specific proteins, which orchestrate the neurotransmitter turnover, neurogenesis and neuroplasticity. Despite numerous studies of the vitamin D role in normal and pathological brain function, there is little evidence on the mechanisms of alterations in excitatory and inhibitory neurotransmission under vitamin D deficiency (VDD). Read More

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http://dx.doi.org/10.1016/j.biocel.2019.105665DOI Listing
February 2020

Internal herniation following laparoscopic gastric bypass: addressing the mesoclosure technique.

BMJ Case Rep 2019 Nov 26;12(11). Epub 2019 Nov 26.

Department of Surgery, Gladstone Hospital, West Gladstone, Queensland, Australia.

A 49-year-old man presented with a 2-week history of gradual onset progressively worsening left upper quadrant pain. Ten months prior, he had a laparoscopic roux-en-Y gastric bypass (LRYGBP) for severe gastro-oesophageal reflux disease and obesity. On examination, his abdomen was not distended and was soft to palpation. Read More

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http://dx.doi.org/10.1136/bcr-2019-231124DOI Listing
November 2019

Does green tea extract enhance the anti-inflammatory effects of exercise on fat loss?

Br J Clin Pharmacol 2020 Apr 4;86(4):753-762. Epub 2020 Feb 4.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé), Rennes, France.

Aims: Green tea extract (GTE) can exert antiobesity and anti-inflammatory effects. Our study determined whether the benefits of GTE are summative with exercise-induced changes in anthropometric indices, and the levels of inflammatory cytokines, adiponectin and irisin in inactive overweight women.

Methods: Thirty overweight female participants were randomized to 3 groups: endurance training + placebo (ET + P); endurance training + GTE (ET + GTE); and Control (no exercise) + placebo (Control, n = 10). Read More

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http://dx.doi.org/10.1111/bcp.14176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098875PMC

Dietary habits associated with internal hemorrhoidal disease: a case-control study.

Tunis Med 2019 Apr;97(4):572-578

Background: Pathophysiology of the internal hemorrhoidal disease is poorly understood but seems to be multifactorial. Some types of food and lifestyle have been assumed to increase the risk of internal hemorrhoidal disease.  Aims: To identify alimentary habits that are associated with internal hemorrhoidal disease. Read More

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Tick-borne encephalitis virus (TBEV) antibodies in animal sera - occurrence in goat flocks in Germany, longevity and ability to recall immunological information after more than six years.

BMC Vet Res 2019 Nov 6;15(1):399. Epub 2019 Nov 6.

Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Südufer 10, 17493, Greifswald, Insel Riems, Germany.

Background: TBE is an important tick-borne viral zoonosis in Europe and some parts of Asia. Humans can become infected by tick bite and in some cases also by consumption of nonpasteurized raw milk and raw milk products from ruminants. Serological investigations of milking flocks can help to assess the risk of TBEV infection for humans. Read More

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http://dx.doi.org/10.1186/s12917-019-2157-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836345PMC
November 2019

Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis.

BMC Cancer 2019 Oct 29;19(1):1016. Epub 2019 Oct 29.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.

Background: Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemotherapy-induced AM. While the DPP-4 enzyme degrades this GLP-1, the DPP-4 inhibitor blocks the degradation process and raises the concentration of GLP-1. Read More

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http://dx.doi.org/10.1186/s12885-019-6231-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819400PMC
October 2019
1 Read

Medicines prescription patterns in European neonatal units.

Int J Clin Pharm 2019 Dec 17;41(6):1578-1591. Epub 2019 Oct 17.

Department of Microbiology, University of Tartu, Tartu, Estonia.

Background Hospitalized neonates receive the highest number of drugs compared to all other age groups, but consumption rates vary between studies depending on patient characteristics and local practices. There are no large-scale international studies on drug use in neonatal units. Objective We aimed to describe drug use in European neonatal units and characterize its associations with geographic region and gestational age. Read More

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http://dx.doi.org/10.1007/s11096-019-00923-2DOI Listing
December 2019

Oral delivery of water-soluble compounds to the phytoseiid mite Neoseiulus californicus (Acari: Phytoseiidae).

PLoS One 2019 16;14(10):e0223929. Epub 2019 Oct 16.

Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.

Phytoseiids are predatory mites that prey on other mites and small arthropods, and several species are used in commercial agriculture for biological control of pests. To optimize phytoseiid mites' use in biocontrol, an efficient method for oral delivery of test compounds is required to assess their sensitivities to pesticides, RNAi for gene functional analysis and artificial diets. Here we developed four methods for oral delivery of a solution of xenobiotics to different life stages of the commercially available generalist predatory mite Neoseiulus californicus: (i) soaking mites in the solution, or allowing them to feed on (ii) spider mites soaked in the solution, (iii) a solution droplet, or (iv) solution-saturated filter paper. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223929PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795443PMC

Anti-inflammatory effects of eriocitrin against the dextran sulfate sodium-induced experimental colitis in murine model.

J Biochem Mol Toxicol 2019 Nov 8;33(11):e22400. Epub 2019 Oct 8.

Department of Talent Highland, First Affiliated Hospital of Xi'an Jiao Tong University, Xian, China.

Inflammatory bowel disease (IBD) is a continual ailment condition which engrosses the entire alimentary canal. The IBD can be primarily distinguished into two forms, ulcerative colitis, and Crohn's disease. The major symptoms of IBD include pustules or abscesses, severe abdominal pain, diarrhea, fistula, and stenosis, which may directly affect the patient's quality of life. Read More

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http://dx.doi.org/10.1002/jbt.22400DOI Listing
November 2019
1 Read

Biocompatible and degradable Bletilla striata polysaccharide hemostasis sponges constructed from natural medicinal herb Bletilla striata.

Carbohydr Polym 2019 Dec 8;226:115304. Epub 2019 Sep 8.

Key Laboratory of Green Processing and Functional New Textile Materials of Ministry of Education, Wuhan Textile University, Wuhan, 430200, China. Electronic address:

Medicinal herb Bletilla striata as a traditional Chinese herb has been used to treat alimentary canal mucosal damage, ulcers, bruises, and burns for thousands of years. Despite numerous efforts directed at the development of Bletilla striata products, the challenge of preparing Bletilla striata hemostasis dressings while simultaneously maintaining portability and high hemostasis performance has not yet been addressed. Herein, we describe a Bletilla striata polysaccharide (BSP) sponge with hierarchical aligned porous channels formed via directional freeze technology. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.115304DOI Listing
December 2019

Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling.

FASEB J 2019 12 9;33(12):13546-13559. Epub 2019 Oct 9.

Alimentary Pharmabiotic Centre (APC) Microbiome Ireland, University College Cork, Cork, Ireland.

The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). The ghrelin receptor [growth hormone secretagogue receptor (GHSR)-1a] is a GPCR expressed throughout both the gut and the brain and plays a crucial role in maintaining energy balance, metabolism, and the central modulation of food intake, motivation, reward, and mood. To date, few studies have investigated the potential of the gastrointestinal microbiota and its metabolites to modulate GPCR signaling. Read More

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http://dx.doi.org/10.1096/fj.201901433RDOI Listing
December 2019
1 Read

Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: a phase 2a, randomised, double-blind, placebo-controlled, parallel-group study.

Lancet Gastroenterol Hepatol 2019 12 4;4(12):960-970. Epub 2019 Sep 4.

Department of Gastroenterology and Hepatology, Amsterdam UMC, Vrije Universiteit Medical Centre, Amsterdam, Netherlands.

Background: Refractory coeliac disease type 2 is a rare subtype of coeliac disease with high mortality rates; interleukin 15 (IL-15) is strongly implicated in its pathophysiology. This trial aimed to investigate the effects of AMG 714, an anti-IL-15 monoclonal antibody, on the activity and symptoms of refractory coeliac disease type 2.

Methods: This was a randomised, double-blind, placebo-controlled, phase 2a study of adults with a confirmed diagnosis of refractory coeliac disease type 2. Read More

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http://dx.doi.org/10.1016/S2468-1253(19)30265-1DOI Listing
December 2019
2 Reads

Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia.

Curr Diab Rep 2019 09 6;19(10):97. Epub 2019 Sep 6.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Purpose Of Review: New more stable formulations of glucagon have recently become available, and these provide an opportunity to expand the clinical roles of this hormone in the prevention and management of insulin-induced hypoglycemia. This is applicable in type 1 diabetes, hyperinsulinism, and alimentary hypoglycemia. The aim of this review is to describe these new formulations of glucagon and to provide an overview of current and future therapeutic opportunities that these may provide. Read More

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http://dx.doi.org/10.1007/s11892-019-1216-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951434PMC
September 2019
9 Reads

Specific anatomy and radiographic illustration of the digestive tract and transit time of two orally administered contrast media in Inland bearded dragons (Pogona vitticeps).

PLoS One 2019 22;14(8):e0221050. Epub 2019 Aug 22.

Department of Reptiles and Amphibians, Clinic for Small Mammals, Reptiles and Birds, University of Veterinary Medicine, Hannover, Germany.

The aim of this study was to describe the specific gross and radiographic anatomy of the digestive tract of inland bearded dragons (Pogona vitticeps). Eleven bearded dragon cadavers of both sexes (6 females, 5 males) were dissected to examine, measure, and document the specific gross anatomy of the alimentary canal. Measurements collected from the cadavers included snout-vent length, total length of the alimentary canal, and the lengths of the individual sections of the gastrointestinal tract, including the esophagus, stomach, small intestine, ampulla coli, isthmus coli, rectum, and the distance from the coprodeum to the vent opening. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221050PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705840PMC

[Lipolysis in very low density lipoproteins - locus minoris resistentiae - in the pathogenesis of hypertriglyceridemia. Positive effects of diet, polyenic fatty acids, statins and fibrates.]

Klin Lab Diagn 2019 ;64(7):388-396

Krasnoyarsk V.F. Voyno-Yasenetsky State Medical University, Ministry of Health, Krasnoyarsk.

Inhibition of hydrolysis of palmitic and oleic triglycedires (TG) in very low density lipoproteins (VLDL), slow formation of active apoВ-100 conformation, blockade of апоЕ/В-100 ligand formation in VLDL and their reduced uptake by insulin-dependent cells cause hypertriglyceridemia (HTG). Palmitic and oleic VLDL (>80% total VLDL) are not converted in low density lipoproteins (LDL). Atherosclerosis is not an alimentary deficiency of polyenic fatty acids (PFA), but results from low in vivo bioavailability of PFA in LDL against the background of high dietary palmitic FA and palmitic LDL. Read More

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http://dx.doi.org/10.18821/0869-2084-2019-64-7-388-396DOI Listing
August 2019
1 Read

Chronic Fistula Post Laparoscopic Nissen Sleeve Gastrectomy: Conversion to Roux-en-Y Gastric Bypass.

Obes Surg 2019 10;29(10):3414-3415

Division of Digestive Surgery and Liver Transplantation, Nice University Hospital, Nice, France.

Background: Sleeve gastrectomy (SG) is the most frequently performed bariatric intervention worldwide, and obese patients have a higher risk of developing reflux symptoms compared with the general population [1, 2]. One of the controversies of SG is to perform it in patients with gastroesophageal reflux disease (GERD). Some studies have shown that SG may exacerbate GERD symptoms or even increase the risk of "de novo" postoperative GERD [3, 4]. Read More

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http://dx.doi.org/10.1007/s11695-019-04080-3DOI Listing
October 2019
4 Reads
3.747 Impact Factor

A new method to induce nonalcoholic steatohepatitis (NASH) in mice.

BMC Gastroenterol 2019 Jul 15;19(1):125. Epub 2019 Jul 15.

Physiology Research Center (PRC), Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: General overnutrition is one of the key factors involved in the development of nonalcoholic fatty liver disease (NAFLD) as the most common liver disease occur by two steps of liver injury ranges from steatosis to nonalcoholic steatohepatitis (NASH). Here the effect of fructose, fat-rich and western diet (WD) feeding was studied along with aggravative effect of cigarette smoking on liver status in mice.

Methods: Sixty-four male NMRI mice were included in this study and assigned into 4 groups that fed standard, fructose-rich, high fat-, and western-diet for 8 weeks and then each group divided in two smoker and nonsmoker subgroups according to smoke exposing in the last 4 weeks of feeding time (n = 8). Read More

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http://dx.doi.org/10.1186/s12876-019-1041-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632212PMC
July 2019
3 Reads

Boswellic extracts and 11-keto-ß-boswellic acids prevent type 1 and type 2 diabetes mellitus by suppressing the expression of proinflammatory cytokines.

Authors:
H P T Ammon

Phytomedicine 2019 Oct 28;63:153002. Epub 2019 Jun 28.

Department of Pharmacology and Toxicology, Institute of Pharmaceutical Sciences, University of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany. Electronic address:

Background: Type 1 diabetes is an autoimmune disease directed to the pancreatic islets where inflammation leads to the death of insulin-producing ß cells and insulin deficiency. Type 2 diabetes, which is closely related to overweight, is characterized by insulin resistance. In both cases, proinflammatory cytokines play an important role by causing insulitis and insulin resistance. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.153002DOI Listing
October 2019
1 Read

Short Gastric Pouch for Laparoscopic Conversion of Failed Band to Roux-en-Y Gastric Bypass.

Obes Surg 2019 09;29(9):3091-3092

Université Côte d'Azur, Nice, France.

Background: Laparoscopic gastric banding (LGB) is associated with high rate of failure (Stenard and Iannelli. World J Gastroenterol; 21:10348-57 2015, Lazzati et al. Ann Surg. Read More

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http://dx.doi.org/10.1007/s11695-019-04058-1DOI Listing
September 2019
4 Reads

Outcomes of Long Pouch Gastric Bypass (LPGB): 4-Year Experience in Primary and Revision Cases.

Obes Surg 2019 11;29(11):3665-3671

Obesity and Endocrine Diseases Unit, Department of Surgery, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Background: One of the most important complications of the one anastomosis gastric bypass (OAGB) is enterobilio acid reflux (EBAR). We report the concept of the long pouch Roux-en-Y gastric bypass (LPRYGB) meaning a Roux-en-Y with a long pouch and a 100-cm alimentary limb to avoid EBAR, with a long biliopancreatic limb to increase metabolic effects.

Methods: A total of 300 LPRYGB cases in a 4-year period, with a 90% follow-up rate, were analysed. Read More

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http://dx.doi.org/10.1007/s11695-019-04051-8DOI Listing
November 2019
2 Reads

[Immunological markers of alimentary-induced hyperlipidemia in Wistar rats].

Vopr Pitan 2019;88(3):44-52. Epub 2019 May 20.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

Changes in plasma levels of the main groups of cytokines and adipokines may correlate with the severity of metabolic disorders in hyperlipidemia and obesity. of the study was to assess the significance of ghrelin, leptin, their ratio (L/Gh), and the cytokine profile as biomarkers at dietary-induced hyperlipidemia. . Read More

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http://dx.doi.org/10.24411/0042-8833-2019-10028DOI Listing
December 2019
1 Read

Pancreatic resections are not only safest but also most cost-effective when performed in a high-volume centre: A Finnish register study.

Pancreatology 2019 Jul 18;19(5):769-774. Epub 2019 Jun 18.

Dept. of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland; Medical School, University of Tampere, Finland. Electronic address:

Background: It is not known whether the treatment costs of pancreatic surgery can be reduced by centralisation. The aim of this study was to analyse the impact of hospital volume on the short-term prognosis and costs in a nationwide study.

Methods: The National registry was searched for patients undergoing pancreatoduodenectomy (PD) in Finland between 2012 and 2014. Read More

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http://dx.doi.org/10.1016/j.pan.2019.06.007DOI Listing

[ study of plant protein products from soybeans and non-alkaloid lupine Dega variety].

Vopr Pitan 2019;88(2):24-31. Epub 2019 Mar 13.

V.M. Gorbatov Federal Research Center for Food Systems of Russian Academy of Sciences, Moscow, Russia.

Research on finding additional sources of vegetable protein as an alternative to soy has shown a great prospect of using lupine. The study of biological effects of flour of nonalkaloid lupine Dega variety will assess the future prospects for its use in food industry. - a comparative study of protein products - soybean flour and non-alkaloid lupine flour (Dega-1 variety), added to laboratory rats' diet. Read More

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http://dx.doi.org/10.24411/0042-8833-2019-10014DOI Listing
December 2019
7 Reads

Multicentre randomized clinical trial of colonic J pouch or straight stapled colorectal reconstruction after low anterior resection for rectal cancer.

Br J Surg 2019 08 24;106(9):1147-1155. Epub 2019 Jun 24.

Department of Colorectal Surgical Oncology, Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale, Naples, Italy.

Background: Colonic J pouch reconstruction has been found to be associated with a lower incidence of anastomotic leakage than straight anastomosis. However, studies on this topic are underpowered and retrospective. This randomized trial evaluated whether the incidence of anastomotic leakage was reduced after colonic J pouch reconstruction compared with straight colorectal anastomosis following anterior resection for rectal cancer. Read More

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http://dx.doi.org/10.1002/bjs.11222DOI Listing
August 2019
9 Reads

Copper and copper nanoparticles toxicity and their impact on basic functions in the body.

Authors:
M Pohanka

Bratisl Lek Listy 2019 ;120(6):397-409

Copper is a biogenic metal having multiple functions in basic processes in organisms and it is common in all kingdoms of life. Limited intake of copper is a problem; however, doses of copper exceeding the recommended alimentary source are problematic as well and toxicity is soon manifested. Impact of copper nanoparticles on human health is another serious issue taken into consideration in this review. Read More

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http://dx.doi.org/10.4149/BLL_2019_065DOI Listing
August 2019
8 Reads

Influence of Diets with Varying Essential/Nonessential Amino Acid Ratios on Mouse Lifespan.

Nutrients 2019 Jun 18;11(6). Epub 2019 Jun 18.

Department of Internal Medicine, University of Cagliari, 09042 Monserrato (Cagliari), Italy.

An adequate intake of essential (EAA) and non-essential amino acids (NEAA) is crucial to preserve cell integrity and whole-body metabolism. EAA introduced with diet may be insufficient to meet the organismal needs, especially under increased physiological requirements or in pathological conditions, and may condition lifespan. We therefore examined the effects of iso-caloric and providing the same nitrogenous content diets, any diet containing different stoichiometric blends of EAA/NEAA, on mouse lifespan. Read More

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http://dx.doi.org/10.3390/nu11061367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628056PMC
June 2019
11 Reads

Olive oil antioxidants and non-alcoholic fatty liver disease.

Expert Rev Gastroenterol Hepatol 2019 Aug 25;13(8):739-749. Epub 2019 Jun 25.

c Department of Agricultural, University "Mediterranea" , Reggio, Calabria , Italy.

: Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25% of adult people worldwide. Nowadays, there is no definite treatment for NAFLD. International guidelines define an approach based on lifestyle changes, included a health alimentary regimen. Read More

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http://dx.doi.org/10.1080/17474124.2019.1634544DOI Listing
August 2019
15 Reads

Perioperative hydrocortisone treatment reduces postoperative pancreatic fistula rate after open distal pancreatectomy. A randomized placebo-controlled trial.

Pancreatology 2019 Jul 18;19(5):786-792. Epub 2019 May 18.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Finland. Electronic address:

Background: Postoperative pancreatic fistula (POPF) is the most common complication after distal pancreatectomy (DP). In a recent RCT on pancreaticoduodenectomy (PD), perioperative hydrocortisone (HC) treatment reduced Clavien-Dindo (C-D) III-V complications. The aim of this study was to investigate whether perioperative HC treatment reduces the overall complications and clinically significant POPF after distal pancreatectomy (DP). Read More

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http://dx.doi.org/10.1016/j.pan.2019.05.457DOI Listing
July 2019
1 Read

Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3.

PLoS Genet 2019 05 23;15(5):e1008145. Epub 2019 May 23.

Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, Leipzig, Germany.

The interplay of microbiota and the human host is physiologically crucial in health and diseases. The beneficial effects of lactic acid bacteria (LAB), permanently colonizing the human intestine or transiently obtained from food, have been extensively reported. However, the molecular understanding of how LAB modulate human physiology is still limited. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532841PMC
May 2019
6 Reads

Case Report: Vitamin A Deficiency and Nyctalopia in a Patient with Chronic Pancreatitis.

Optom Vis Sci 2019 06;96(6):453-458

VA Southern Nevada Healthcare System, North Las Vegas, Nevada.

Significance: Vitamin A deficiency is a known concern in developing countries, but it is often overlooked in developed regions. A history of conditions causing alimentary malabsorption should be considered when patients present with complaints of nyctalopia.

Purpose: A case of vitamin A deficiency with nyctalopia in a patient with chronic pancreatitis including pertinent diagnostic testing, treatment, and management is presented. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001385DOI Listing
June 2019
8 Reads

Impact of Biliopancreatic Limb Length (70 cm vs 120 cm), with Constant 150 cm Alimentary Limb, on Long-Term Weight Loss, Remission of Comorbidities and Supplementation Needs After Roux-En-Y Gastric Bypass: a Prospective Randomized Clinical Trial.

Obes Surg 2019 08;29(8):2367-2372

Department of Surgery, Hospital Universitario Fundación Jimenez Diaz, Madrid, Spain.

Background: The best alimentary and biliopancreatic limb (BPL) lengths in the Roux-en-Y gastric bypass (RYGB) still remain unclear. The aim of this study was to compare the effect of a BPL of 70 vs 120 cm, with a constant AL of 150 cm on long-term weight loss, remission of comorbidities, and supplementation needs after RYGB.

Patients And Methods: A prospective randomized study of morbidly obese patients undergoing RYGB was performed. Read More

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http://dx.doi.org/10.1007/s11695-019-03717-7DOI Listing
August 2019
1 Read
3.747 Impact Factor

Analysis of Disposed Unused Medications at a Village Community Pharmacy.

Pharmacy (Basel) 2019 May 12;7(2). Epub 2019 May 12.

Department of Clinical Pharmacology and Therapeutics, University of Malta, MSD2080 Msida, Malta.

The aim of this study was to determine the type, quantity, and cost of medications being disposed of by clients in a specifically-set pharmaceutical disposal bin at a village community pharmacy. Medicines placed in a medication disposal bin by clients were examined during a nine-month period from April to December 2018. The data recorded included the active ingredient, trade name, dose, dosage form, disposed quantity, and the actual expiry date on the pack. Read More

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http://dx.doi.org/10.3390/pharmacy7020045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630273PMC
May 2019
3 Reads

[Dietary control of metabolic acidosis in chronic kidney disease].

Nephrol Ther 2019 Dec 2;15(7):491-497. Epub 2019 May 2.

Service de néphrologie-hémodialyse, centre hospitalier de Dunkerque, 130, avenue Louis-Herbeaux, 59240 Dunkerque, France.

Metabolic acidosis is a frequent complication of chronic kidney disease. Although it is known to appear at advanced stages, many studies suggest a state of "global protonic retention" starting at early stages of the disease, responsible of tissue damage, particularly musculoskeletal, alteration of protidic metabolism and endocrine disorders, promoting malnutrition and chronic inflammation, and finally increasing mortality. The majority of international recommandations suggest of supplementation by alkali, most of the time by sodium bicarbonate, to struggle against this complication. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.12.001DOI Listing
December 2019
4 Reads

Complications After endoscopic balloon dilatation of esophageal strictures in children. Experience from a tertiary center in Shiraz - Iran (Nemazee Teaching Hospital).

Rev Gastroenterol Peru 2019 Jan-Mar;39(1):7-11

Dept. Of Pediatric Surgery, Nemazee Teaching Hospital, Shiraz University of Medical Sciences. Shiraz, Iran.

Background: Esophageal stricture is one of the most important complication of the caustic ingestion.

Objective: The aim of this study was to evaluate complications of balloon dilatation among children with esophageal stenosis.

Material And Methods: In this retrospective study 82 children were included. Read More

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January 2020
2 Reads

Evaluation of the therapeutic potential effect of Fas receptor gene knockdown in experimental model of non-alcoholic steatohepatitis.

Free Radic Res 2019 May 7;53(5):486-496. Epub 2019 May 7.

c Persian Gulf's Physiology Research Center (PRC), Alimentary Tract Research Center, Department of Physiology, School of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Stimulation of Fas death receptor is introduced as a major cause of non-alcoholic steatohepatitis (NASH) progression through suppression of cell viability. Therefore, the blocking of death pathways is hypothesised to be express new approaches to NASH therapy. For this purpose, current experiment applied synthetic small interference RNA (SiRNA) to trigger Fas death receptor and to show its potential therapeutic role in designed NASH model. Read More

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http://dx.doi.org/10.1080/10715762.2019.1608982DOI Listing
May 2019
1 Read

Kynurenic acid as the neglected ingredient of commercial baby formulas.

Sci Rep 2019 04 15;9(1):6108. Epub 2019 Apr 15.

Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Jaczewskiego 8b, PL-20090, Lublin, Poland.

The global increase in resorting to artificial nutritional formulas replacing breastfeeding has been identified among the complex causes of the obesity epidemic in infants and children. One of the factors recently recognized to influence metabolism and weight gain is kynurenic acid (KYNA), an agonist of G protein-coupled receptor (GPR35). Therefore the aim of the study was to determine the concentration of KYNA in artificial nutritional formulas in comparison with its level in human breast milk and to evaluate developmental changes in rats exposed to KYNA enriched diet during the time of breastfeeding. Read More

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http://www.nature.com/articles/s41598-019-42646-4
Publisher Site
http://dx.doi.org/10.1038/s41598-019-42646-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465401PMC
April 2019
24 Reads

Effects of Titanium Dioxide Nanoparticles Exposure on Human Health-a Review.

Biol Trace Elem Res 2020 Jan 13;193(1):118-129. Epub 2019 Apr 13.

Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland.

Recently, an increased interest in nanotechnology applications can be observed in various fields (medicine, materials science, pharmacy, environmental protection, agriculture etc.). Due to an increasing scope of applications, the exposure of humans to nanoparticles (NPs) is inevitable. Read More

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http://link.springer.com/10.1007/s12011-019-01706-6
Publisher Site
http://dx.doi.org/10.1007/s12011-019-01706-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914717PMC
January 2020
15 Reads