12,904 results match your criteria Alimentary Pharmacology & Therapeutics[Journal]


Long term outcome of a subcutaneous colonic interposition after pharyngo-laryngectomy for strictures of the larynx and hypopharynx resulting from caustic ingestion: A case report.

Int J Surg Case Rep 2022 May 19;95:107215. Epub 2022 May 19.

University Of The Philippines Manila Philippine General Hospital, Philippines.

Introduction: Caustic agents, also called corrosive agents, could be acids or alkali in nature. If ingested, these agents can injure any part of the aerodigestive tree. Extent of injury depends on the type, concentration, duration of exposure and volume of caustic agent ingested. Read More

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[Sex, gender and stature: From biology to culture - and back].

Med Sci (Paris) 2022 May 24;38(5):464-471. Epub 2022 May 24.

Laboratoire de biologie des tissus ostéo-articulaires, UMR Inserm U1059-SAINBIOSE (santé ingéniérie biologie St-Étienne), Université Jean Monnet, Campus santé innovation, 10 rue de la Marandière, 42270 Saint-Priest-en-Jarez, France.

The origin of sexual dimorphism of stature (SSD) in the human species is a subject of debate, likely to have a sociocultural impact. Stature is optimally expressed in good environmental conditions, notably good food, with a strong hereditary determinism. The common academic interpretation, already proposed by Darwin, is that SSD results from sexual selection of stronger males, in most species of mammals, including humans. Read More

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The contribution of gastrointestinal microbiota in the existence of type 2 diabetes in Saudi Arabia: Current information and perspectives.

Saudi J Biol Sci 2022 Jun 21;29(6):103286. Epub 2022 Apr 21.

Department of Biological Science, College of Science, King Abdulaziz University, 42742, University Avenue, Jeddah 21551, Saudi Arabia.

Diabetes mellitus (DM) is a genuine international health issue, with Saudi Arabia ranking among the top nations with the largest diabetes prevalence. Following the International Diabetes Federation (IDF), 3.8 million Saudi Arabian people had diabetes in 2014. Read More

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Diaphragmatic Hernia with Gastric Volvulus and Complete Gastric Outlet Obstruction.

J Minim Invasive Surg 2020 Dec;23(4):197-200

Bariatric Unit, General Surgery Department, Al-Qassimi Hospital, Sharjah, United Arab Emirates.

A combination of Cytoreductive surgery (CRS) along with hyperthermic intraperitoneal chemotherapy (HIPEC) considers a crucial approach in treating designated patients with alimentary and gynecological malignancies with the involvement of the peritoneal cavity. The foremost frequent surgical complications are leakage, digestive perforations, fistulas, intestinal obstruction, abscess, and peripancreatitis. This report presents a case of a patient with a late acquired herniation of guts through the diaphragm after CRS and HIPEC that were already done 6 months back. Read More

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December 2020

High complication rate in Crohn's disease surgery following percutaneous drainage of intra-abdominal abscess: a multicentre study.

Int J Colorectal Dis 2022 May 23. Epub 2022 May 23.

Department of Advanced Medical and Surgical Science, Universita' Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.

Introduction: Intra-abdominal abscesses complicating Crohn's disease (CD) present an additional challenge as their presence can contraindicate immunosuppressive treatment whilst emergency surgery is associated with high stoma rate and complications. Treatment options include a conservative approach, percutaneous drainage, and surgical intervention. The current multicentre study audited the short-term outcomes of patients who underwent preoperative radiological drainage of intra-abdominal abscesses up to 6 weeks prior to surgery for ileocolonic CD. Read More

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Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis.

Obes Surg 2022 May 21. Epub 2022 May 21.

Department of Gastrointestinal Surgery, The affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan, 523320, China.

This meta-analysis aimed to evaluate changes in GIP after RYGB in obese patients. We searched PubMed, EMBASE, and CENTRAL for relevant studies from database inception through July 2021. Articles were eligible for inclusion if they reported pre-operative and post-operative fasting GIP levels. Read More

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D-Allose, a rare sugar. Synthesis of D-allopyranosyl acceptors from glucose, and their regioselectivity in glycosidation reactions.

Org Biomol Chem 2022 May 20. Epub 2022 May 20.

CIHIDECAR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428 Buenos Aires, Argentina.

Although D-allose (D-All) is a sugar with low natural abundance, it has great pharmacological and alimentary potential due to its biological properties. However, its chemistry, regarding the regioselectivity in protective reactions and glycosidations, has been scarcely explored. Glycobiological studies require appreciable quantities of carbohydrates with defined structures and high purity. Read More

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Molecular and immunological characterization of cysteine protease from Phaseolus vulgaris and evolutionary cross-reactivity.

J Food Biochem 2022 May 20:e14232. Epub 2022 May 20.

Allergy and Immunology Section, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

A commonly consumed legume in India, the kidney bean (Phaseolus vulgaris) is associated with allergy. We report molecular and immunological characterization of cysteine protease allergen and its cross-reactivity. In silico allergenicity assessment and phylogenetic analysis of kidney bean cysteine protease showed significant sequence homology (upto 67%) with allergens from kiwi, papaya, soybean, ragweed pollen and mites. Read More

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Mortality and causes of death in different celiac disease phenotypes during long-term follow-up.

Dig Liver Dis 2022 May 17. Epub 2022 May 17.

Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Internal Medicine, Tampere University Hospital, Tampere, Finland.

Background: Celiac disease has been associated with increased mortality, but data on long-term mortality are scarce.

Aims: To determine long-term mortality in celiac disease.

Methods: The study cohort consisted of all celiac disease patients (n=1,392) diagnosed in Tampere University Hospital catchment area 1960 - 2000. Read More

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Alimentary Tract Neoplasia in Captive Bearded Dragons (Pogona spp).

J Comp Pathol 2022 Jun 25;194:28-33. Epub 2022 Apr 25.

Northwest ZooPath, Monroe, Washington, USA.

There are multiple reports of gastric neuroendocrine carcinoma in bearded dragons (Pogona spp), but other types of alimentary neoplasia are rarely reported. In a retrospective study, we identified 51 cases of neoplasia, including gastric (n = 26), oral (n = 18), intestinal (n = 13), oesophageal (n = 3) and cloacal (n = 2) neoplasms. Round cell neoplasia was diagnosed in the alimentary tract in 14 cases, all of which had extra-alimentary involvement, most commonly in the liver, lung, spleen and kidney, and was considered to be the cause of death or euthanasia in all cases. Read More

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Antibiotics versus placebo in adults with CT-confirmed uncomplicated acute appendicitis (APPAC III): randomized double-blind superiority trial.

Br J Surg 2022 May;109(6):503-509

Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland.

Background: Non-operative management of uncomplicated acute appendicitis is an option, but omission of antibiotics from the regimen has not been tested.

Methods: A double-blind, placebo-controlled, superiority RCT in adults with CT-confirmed uncomplicated acute appendicitis was designed to compare placebo with antibiotics (intravenous ertapenem followed by oral levofloxacin and metronidazole). The primary endpoint was treatment success (resolution resulting in discharge without appendicectomy within 10 days); secondary outcomes included pain scores, complications, hospital stay, and return to work. Read More

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Fate of undigested proteins in the pig large intestine: What impact on the colon epithelium?

Anim Nutr 2022 Jun 17;9:110-118. Epub 2021 Sep 17.

Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.

Apart from its obvious agronomic interest in feeding billions of people worldwide, the porcine species represents an irreplaceable experimental model for intestinal physiologists and nutritionists. In this review, we give an overview on the fate of proteins that are not fully digested in the pig small intestine, and thus are transferred into the large intestine. In the large intestine, dietary and endogenous proteins are converted to peptides and amino acids (AA) by the action of bacterial proteases and peptidases. Read More

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Soil Environments Influence Gut Prokaryotic Communities in the Larvae of the Invasive Japanese Beetle Newman.

Front Microbiol 2022 27;13:854513. Epub 2022 Apr 27.

Soil Insect Ecology Laboratory, Department of Entomology, Purdue University, West Lafayette, IN, United States.

Invasive scarab beetles, like the Japanese beetle Newman (JB), spend most of their lives as larvae feeding in the soil matrix. Despite the potential importance of the larval gut microbial community in driving the behavior, physiology, and nutritional ecology of this invasive insect, the role of soil biological and physicochemical characteristics in shaping this community are relatively unknown. Our objectives were to (1) characterize the degree to which larval gut microbial communities are environmentally acquired, (2) examine the combined effects of the gut region (i. Read More

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Quantification and composition of pharmaceutical waste in New Zealand.

J Mater Cycles Waste Manag 2022 May 10:1-9. Epub 2022 May 10.

School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023 New Zealand.

This study aimed to quantify the amount of pharmaceutical waste produced in New Zealand, and determine the composition of pharmaceutical waste from community pharmacies in Auckland, New Zealand. Pharmaceutical waste collected in New Zealand is increasing, peaking at 542 tonne in 2019. Pharmaceutical waste collected from hospitals and pharmacies in Auckland increased by more than fourfold from 2016 to 2020. Read More

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Myoglobin Interaction with Lactate Rapidly Releases Oxygen: Studies on Binding Thermodynamics, Spectroscopy, and Oxygen Kinetics.

Int J Mol Sci 2022 Apr 26;23(9). Epub 2022 Apr 26.

Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.

Myoglobin (Mb)-mediated oxygen (O) delivery and dissolved O in the cytosol are two major sources that support oxidative phosphorylation. During intense exercise, lactate (LAC) production is elevated in skeletal muscles as a consequence of insufficient intracellular O supply. The latter results in diminished mitochondrial oxidative metabolism and an increased reliance on nonoxidative pathways to generate ATP. Read More

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A review of research on the impact of E171/TiO NPs on the digestive tract.

J Trace Elem Med Biol 2022 Apr 28;72:126988. Epub 2022 Apr 28.

Institute of Animal Nutrition and Bromatology, Department of Bromatology and Food Physiology, University of Life Sciences in Lublin, Akademicka 13, Lublin 20-950, Poland.

Nanotechnology utilises particles of between 1 and 100 nm in size. In recent years, it has enjoyed widespread application in a variety of areas. However, this has also raised increasing concerns regarding the effects that the use of nanoparticles may have on human health. Read More

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Incidence of alimentary and respiratory disease in brachycephalic dogs presenting to primary care veterinary practices participating in the SAVSNET project.

Vet Rec 2022 May 12:e1685. Epub 2022 May 12.

Northwest Veterinary Specialists, Runcorn, UK.

Background: Brachycephalic dogs clinically affected by brachycephalic obstructive airway syndrome have been shown to have a high incidence of gastrointestinal disease, with French Bulldogs (FBD) identified as a particularly affected breed.

Methods: Clinical records of 750 brachycephalic dogs attending over 500 practices participating in the small animal veterinary surveillance network (SAVSNET) project were analysed in this cohort study to determine the incidence of alimentary and respiratory disease within FBD, Bulldogs (BD) and Pugs attending primary care veterinary practice. Electronic clinical records were studied for treatment or acknowledgement of specific clinical signs that could be attributed to different anatomical locations. Read More

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A population based case-control study of association between dietary calcium intake and ulcerative colitis in adults.

Sci Rep 2022 May 12;12(1):7913. Epub 2022 May 12.

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran, Iran.

Limited data are available on the association of dietary calcium intake and ulcerative colitis (UC). We aimed to investigate the relation between dietary calcium intake and UC prevalence in Iranian adults. In this population-based case-control study, diagnosed patients with UC by gastroenterologists that were registered in the Iranian inflammatory bowel disease registry were included as cases. Read More

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Understanding of the Nutri-Score front-of-pack label by Italian Medical Professionals and its effect on food choices: a web-based study on knowledge, attitudes and practices.

Acta Biomed 2022 May 11;93(2):e2022042. Epub 2022 May 11.

AUSL-IRCCS di Reggio Emilia, Laboratorio Analisi Chimico Cliniche e Microbiologiche, Ospedale Civile di Guastalla, I-42016 Guastalla (RE), Italy.

Background And Aim: A growing number of European Countries have adopted front-of-pack nutrition labels (FPNL) in order to assist costumers' alimentary choices, and particularly Nutri-Score. While its acceptance in Italy has been slowed by ongoing debates, we assessed corresponding knowledge, attitudes and practices of a sample of Italian Medical Professionals (MP).

Methods: A total of 153 MP participated into an internet-based survey by completing a structured questionnaire. Read More

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Chemical composition and antifungal activities of aromatic water of Boiss.

Curr Med Mycol 2021 Sep;7(3):29-35

Department of Medical Mycology and Parasitology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Purpose: In Iranian culture, aromatic waters harboring a slight amount of essential oil have been popularly used for many years as a pleasant non-alcoholic drink with various medicinal properties.In this study, chemical composition of Boiss. (ZM) aromatic water was determined and its and in vivo antifungal properties were investigated. Read More

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September 2021

Identification of patients with branch-duct intraductal papillary mucinous neoplasm and very low risk of cancer: multicentre study.

Br J Surg 2022 May 3. Epub 2022 May 3.

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Background: Different surveillance strategies for patients with low-risk branch-duct (BD) intraductal papillary neoplasm (IPMN) have been described. The aim of this study was to describe the natural history of low-risk BD-IPMN, and to identify risk factors for the development of worrisome features (WF)/high-risk stigmata (HRS) and of pancreatic malignancies.

Methods: This was a multicentre retrospective study of patients with BD-IPMN who were under active surveillance between January 2006 and December 2015. Read More

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Efficacy of the systemic co-administration of vitamin D3 in reversing the inhibitory effects of sodium alendronate on orthodontic tooth movement: A preliminary experimental animal study.

Am J Orthod Dentofacial Orthop 2022 Apr 29. Epub 2022 Apr 29.

Private practice, Tehran, Iran.

Introduction: Bisphosphonates can severely slow down orthodontic tooth movement (OTM) by reducing bone turnover. This calls for materials and methods to reverse or neutralize their effects on OTM. We propose systemic vitamin D3 (D3) for this purpose. Read More

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Two Clinical Cases of Feline Hemoplasmosis in Korea.

Korean J Parasitol 2022 Apr 20;60(2):127-131. Epub 2022 Apr 20.

College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.

Feline hemotropic mycoplasmosis (hemoplasmosis) is an infection of the red blood cells caused by the Mycoplasma haemofelis (Mhf), Candidatus Mycoplasma haemominutum (CMhm), and Candidatus Mycoplasma turicensis (CMt). The existence of Mhf, CMhm, and CMt has been demonstrated in feral cats in Korea using molecular methods, but no clinical cases have yet been reported. This study reports 2 clinical cases of hemotropic mycoplasmosis caused by CMhm and CMt in 2 anemic cats. Read More

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Severe Dysphagia is Rare After Magnetic Sphincter Augmentation.

World J Surg 2022 Apr 29. Epub 2022 Apr 29.

Department of Surgery, Division of General Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: Dysphagia remains the most significant concern after anti-reflux surgery, including magnetic sphincter augmentation (MSA). The aim of this study was to evaluate postoperative dysphagia rates, its risk factors, and management after MSA.

Methods: From a prospectively collected database of all 357 patients that underwent MSA at our institution, a total of 268 patients were included in our retrospective study. Read More

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A One-Health Approach to Investigating an Outbreak of Alimentary Tick-Borne Encephalitis in a Non-endemic Area in France (Ain, Eastern France): A Longitudinal Serological Study in Livestock, Detection in Ticks, and the First Tick-Borne Encephalitis Virus Isolation and Molecular Characterisation.

Front Microbiol 2022 11;13:863725. Epub 2022 Apr 11.

ANSES, INRAE, Ecole Nationale Vétérinaire d'Alfort, UMR VIROLOGIE, Laboratoire de Santé Animale, Maisons-Alfort, France.

Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. Read More

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Characterization of diet based nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in rodent models: Histological and biochemical outcomes.

Histol Histopathol 2022 Apr 27:18462. Epub 2022 Apr 27.

Abadan University of Medical Sciences, Abadan, Iran.

Nonalcoholic fatty liver disease (NAFLD), as the most common chronic liver disease, is rapidly increasing worldwide. This complex disorder can include simple liver steatosis to more serious stages of nonalcoholic fibrosis and steatohepatitis (NASH). One of the critical concerns in NASH research is selecting and confiding in relying on preclinical animal models and experimental methods that can accurately reflect the situation in human NASH. Read More

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Effects of an online home-based exercise intervention on breast cancer survivors during COVID-19 lockdown: a feasibility study.

Support Care Cancer 2022 Jul 26;30(7):6287-6297. Epub 2022 Apr 26.

MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, 11519, Puerto Real, Spain.

Purpose: The strict lockdown implemented due the COVID-19 pandemic is generating a great impact on wellbeing and health-related quality of life (HRQoL) in people with cancer. We aimed to evaluate the efficacy and feasibility of an online home-based exercise intervention performed during a lockdown period analysing its effects on body composition, physical fitness, and HRQoL in breast cancer survivors.

Methods: Fifteen women with breast cancer receiving hormonal therapy (55. Read More

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Non-psychotropic cannabinoids as inhibitors of TET1 protein.

Bioorg Chem 2022 Apr 6;124:105793. Epub 2022 Apr 6.

Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455/2, 128 08 Prague 2, Czech Republic; BIOCEV, First Faculty of Medicine, Charles University, Průmyslová 595, 252 50 Vestec, Czech Republic; Department of Analytical Chemistry, Faculty of Chemical Engineering, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic. Electronic address:

Non-psychotropic cannabinoids (e.g., cannabidiol, cannabinol and cannabigerol) are contained in numerous alimentary and medicinal products. Read More

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Biomolecules from Plant Wastes Potentially Relevant in the Management of Irritable Bowel Syndrome and Co-Occurring Symptomatology.

Molecules 2022 Apr 8;27(8). Epub 2022 Apr 8.

Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, Carol I Avenue, no. 22a, 700506 Iasi, Romania.

During and following the processing of a plant's raw material, considerable amounts are wasted, composted, or redistributed in non-alimentary sectors for further use (for example, some forms of plant waste contribute to biofuel, bioethanol, or biomass production). However, many of these forms of waste still consist of critical bioactive compounds used in the food industry or medicine. Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. Read More

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Outbreak of Alimentary Tick-Borne Encephalitis in Eastern Slovakia: An Analysis of Affected Patients and Long-Term Outcomes.

Pathogens 2022 Apr 2;11(4). Epub 2022 Apr 2.

Department of Infectology and Travel Medicine, Faculty of Medicine, Louis Pasteur University Hospital, Pavol Jozef Šafárik University, 041 90 Kosice, Slovakia.

Objective: Tick-borne encephalitis (TBE) is an endemic zoonotic viral disease in many European countries and in the central and eastern parts of Asia. Slovakia reports the highest occurrence of alimentary tick-borne encephalitis in Europe, after the consumption of unpasteurized milk and cheese from domestic ruminants. In May 2016, an outbreak of tick-borne encephalitis that emerged after the consumption of sheep cheese occurred in eastern Slovakia. Read More

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