84,730 results match your criteria Alcoholism - Clinical and Experimental Research[Journal]


Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.

J Am Acad Child Adolesc Psychiatry 2019 Feb 13. Epub 2019 Feb 13.

Objective: Youth with a family history of alcohol use disorder (family history positive; FHP) are at increased risk for developing maladaptive substance use relative to family history negative (FHN) peers. Building on earlier studies demonstrating morphological differences and distinct patterns of neural activation in FHP, the purpose of the present study was to investigate differential intrinsic functional connectivity among brain networks indexing premorbid risk of developing alcohol use disorder (AUD).

Method: The current study examined intrinsic functional connectivity using resting state functional magnetic resonance imaging (fMRI) in 191 adolescents 13 to 18 years with and without family history of alcohol use disorder (AUD) via independent component analysis (ICA), a method enabling data-driven investigation of internetwork and intranetwork connectivity among brain regions at rest. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.12.008DOI Listing
February 2019

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism.

Transl Psychiatry 2019 Feb 14;9(1):89. Epub 2019 Feb 14.

Department of Neuroscience, Icahn School of Medicine at Mt. Sinai, 1425 Madison Ave, New York, NY, USA.

Alcohol exposure triggers changes in gene expression and biological pathways in human brain. We explored alterations in gene expression in the Pre-Frontal Cortex (PFC) of 65 alcoholics and 73 controls of European descent, and identified 129 genes that showed altered expression (FDR < 0.05) in subjects with alcohol dependence. Read More

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http://dx.doi.org/10.1038/s41398-019-0384-yDOI Listing
February 2019

Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

Acute mental health symptoms among individuals receiving a sexual assault medical forensic exam: the role of previous intimate partner violence victimization.

Arch Womens Ment Health 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.

Sexual assault and intimate partner violence (IPV) are common in the USA, and they often co-occur. Individuals with multiple victimization experiences have more severe mental health outcomes compared to those with one victimization. The current study examined mental health symptoms and their association with IPV victimization history among a sample of individuals who experienced a recent sexual assault and received a sexual assault medical forensic examination. Read More

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http://dx.doi.org/10.1007/s00737-019-0947-1DOI Listing
February 2019

Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.

Front Physiol 2019 30;10:38. Epub 2019 Jan 30.

Laboratory of Metabolic Control, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, MD, United States.

Brown adipose tissue (BAT) is proposed to maintain thermal homeostasis through dissipation of chemical energy as heat by the uncoupling proteins (UCPs) present in their mitochondria. The recent demonstration of the presence of BAT in humans has invigorated research in this area. The research has provided many new insights into the biology and functioning of this tissue and the biological implications of its altered activities. Read More

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http://dx.doi.org/10.3389/fphys.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363669PMC
January 2019

Sub-dimensions of Alcohol Use Disorder in Alcohol Preferring and Non-preferring Rats, a Comparative Study.

Front Behav Neurosci 2019 30;13. Epub 2019 Jan 30.

Pharmacology Unit, School of Pharmacy, University of Camerino, Camerino, Italy.

Recent animal models of alcohol use disorder (AUD) are centered in capturing individual vulnerability differences in disease progression. Here, we used genetically selected Marchigian Sardinian alcohol-preferring (msP) and Wistars rats to apply a multidimensional model of AUD adapted from a previously described DSM-IV/DSM-5 multisymptomatic cocaine addiction model. As proof of concept, we hypothesized that msP rats, genetically selected for excessive drinking, would be more prone to develop dependence-like behavior compared to Wistars. Read More

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http://dx.doi.org/10.3389/fnbeh.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364792PMC
January 2019

Effects of Alcoholism upon the Nervous System.

Authors:

Am J Dent Sci 1873 Jun;7(2):77-78

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Therapeutic challenges for concurrent ethanol and nicotine consumption: naltrexone and varenicline fail to alter simultaneous ethanol and nicotine intake by female alcohol-preferring (P) rats.

Psychopharmacology (Berl) 2019 Feb 13. Epub 2019 Feb 13.

Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Neuroscience Research Building, 320 W. 15th Street, Suite 300B, Indianapolis, IN, 46202-2266, USA.

Rationale And Objectives: Simultaneous alcohol and nicotine consumption occurs in the majority of individuals with alcohol use disorder (AUD) and nicotine dependence. Varenicline (Var) is used to assist in the cessation of nicotine use, while naltrexone (Nal) is the standard treatment for AUD. Despite evidence that ethanol (EtOH) and nicotine (NIC) co-use produces unique neuroadaptations, preclinical research has focused on the effects of pharmacotherapeutics on a single reinforcer. Read More

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http://dx.doi.org/10.1007/s00213-019-5174-yDOI Listing
February 2019

TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.

Neuropsychopharmacology 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.

The nucleus accumbens is a critical integration center for reward-related circuitry and is comprised primarily of medium spiny projection neurons. The dynamic balance of excitation and inhibition onto medium spiny neurons determines the output of this structure. While nucleus accumbens excitatory synaptic plasticity is well-characterized, inhibitory synaptic plasticity mechanisms and their potential relevance to shaping motivated behaviors is poorly understood. Read More

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http://dx.doi.org/10.1038/s41386-019-0341-8DOI Listing
February 2019

Adolescent Internalizing Symptoms and the "Tightknittedness" of Friendship Groups.

J Res Adolesc 2019 Feb 13. Epub 2019 Feb 13.

Florida State University.

Adolescents with depression have lower peer status overall, but tend to befriend each other. We examined the "tightknittedness" of their friendship groups by testing whether adolescent friendship groups' average levels of or variability in internalizing symptoms predict group cohesiveness. We used four waves (9th-12th grades) of survey and social network data on 3,013 friendship groups from the PROmoting School-Community-University Partnerships to Enhance Resilience study. Read More

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http://dx.doi.org/10.1111/jora.12484DOI Listing
February 2019

Constitutional Syndrome, Ascites and Duodenal Thickening Presenting as Groove Pancreatitis.

Eur J Case Rep Intern Med 2018 21;5(3):000789. Epub 2018 Mar 21.

Department of Internal Medicine, Hospital Francesc de Borja, Gandia, Valencia, Spain.

Groove pancreatitis (GP) is a very infrequent subtype of chronic pancreatitis affecting the pancreatic-duodenal junction. It usually manifests in middle-aged men with a history of chronic alcoholism, though it has also been described in women and in individuals who do not consume alcohol. Even though the underlying etiology is unclear, chronic alcohol consumption is known to increase the viscosity of the pancreatic juice and exacerbate the inflammatory process. Read More

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http://dx.doi.org/10.12890/2017_000789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346956PMC

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Sci Rep 2019 Feb 12;9(1):1841. Epub 2019 Feb 12.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.

The peptide hormone acyl-ghrelin and its receptor, GHSR, represent intriguing therapeutic targets due to their actions in metabolic homeostasis and reward activity. However, this pleotropic activity makes it difficult to intervene in this system without inducing unwanted effects. Thus, it is desirable to identify passive and active regulatory mechanisms that allow differentiation between functional domains. Read More

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http://dx.doi.org/10.1038/s41598-019-38549-zDOI Listing
February 2019

Primary Intraventricular Hemorrhage Isolated in Cerebral Aqueduct Secondary to Dural Arteriovenous Fistula.

J Vasc Interv Neurol 2018 Nov;10(2):59-61

Department of Neurology, University of Missouri, Columbia, MO, USA.

Objective: We report a case of dural arteriovenous fistula (dAVF) presenting as isolated cerebral aqueduct hemorrhage.

Result: A 73-year-old man with a history of hypertension and chronic alcoholism presented with altered mental status and gait difficulties, bilateral fronto-occipital headaches, and intermittent dizziness. He had bilateral upward gaze restriction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350861PMC
November 2018
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Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency.

Brain Sci 2019 Feb 8;9(2). Epub 2019 Feb 8.

Department of Psychology, Indiana University⁻Purdue University Indianapolis, Indianapolis, IN, 46202, USA.

Negative urgency is a personality trait reflecting the tendency to act rashly in response to extreme negative emotions and is considered a transdiagnostic endophenotype for problematic levels of addictive behaviors. Recent research has begun to identify the neural correlates of negative urgency, many of which appear to overlap with neural circuitry underlying addictive disorders associated with negative urgency. The goal of this qualitative review is to summarize the extant literature concerning the neural correlates of negative urgency, to compare these correlates with those implicated with addictive disorders, and to propose new ways to begin to leverage such findings in treatment and intervention approaches. Read More

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http://dx.doi.org/10.3390/brainsci9020036DOI Listing
February 2019
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Impaired cognitive flexibility following NMDAR-GluN2B deletion is associated with altered orbitofrontal-striatal function.

Neuroscience 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM; New, Mexico, Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM. Electronic address:

A common feature across neuropsychiatric disorders is inability to discontinue an action or thought once it has become detrimental. Reversal learning, a hallmark of executive control, requires plasticity within cortical, striatal and limbic circuits and is highly sensitive to disruption of N-methyl--aspartate receptor (NMDAR) function. In particular, selective deletion or antagonism of GluN2B containing NMDARs in cortical regions including the orbitofrontal cortex (OFC), promotes maladaptive perseveration. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.066DOI Listing
February 2019
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New Estimates of the Mean Ethanol Content of Beer, Wine, and Spirits Sold in the United States Show a Greater Increase in Per Capita Alcohol Consumption than Previous Estimates.

Alcohol Clin Exp Res 2019 Feb 11. Epub 2019 Feb 11.

Advancing New Standards in Reproductive Health (ANSIRH) , Department of Obstetrics, Gynecology & Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California, San Francisco, San Francisco, California.

Background: Recent increases in alcohol-related morbidity and mortality have not occurred alongside notable increases in per capita alcohol consumption (PCC). This discrepancy may be partially due to U.S. Read More

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http://dx.doi.org/10.1111/acer.13958DOI Listing
February 2019

Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain.

Nat Commun 2019 Feb 11;10(1):690. Epub 2019 Feb 11.

National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, 20892, MD, USA.

The correspondence between cerebral glucose metabolism (indexing energy utilization) and synchronous fluctuations in blood oxygenation (indexing neuronal activity) is relevant for neuronal specialization and is affected by brain disorders. Here, we define novel measures of relative power (rPWR, extent of concurrent energy utilization and activity) and relative cost (rCST, extent that energy utilization exceeds activity), derived from FDG-PET and fMRI. We show that resting-state networks have distinct energetic signatures and that brain could be classified into major bilateral segments based on rPWR and rCST. Read More

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http://dx.doi.org/10.1038/s41467-019-08546-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370887PMC
February 2019
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Dissociable Contributions of Precuneus and Cerebellum to Subjective and Objective Neuropathy in HIV.

J Neuroimmune Pharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., Stanford, CA, 94305, USA.

Neuropathy, typically diagnosed by the presence of either symptoms or signs of peripheral nerve dysfunction, remains a frequently reported complication in the antiretroviral (ART)-treated HIV population. This study was conducted in 109 healthy controls and 57 HIV-infected individuals to investigate CNS regions associated with neuropathy. An index of objective neuropathy was computed based on 4 measures: deep tendon ankle reflex, vibration sense (great toes), position sense (great toes), and 2-point discrimination (feet). Read More

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http://dx.doi.org/10.1007/s11481-019-09837-2DOI Listing
February 2019

DSM-5 Alcohol Use Disorder Severity as a Function of Sexual Orientation Discrimination: A National Study.

Alcohol Clin Exp Res 2019 Feb 11. Epub 2019 Feb 11.

Center for the Study of Drugs, Alcohol, Smoking, and Health, School of Nursing, University of Michigan, Ann Arbor, Michigan.

Background: Sexual minorities are more likely than their heterosexual counterparts to develop alcohol use disorder (AUD), and understanding the underlying reasons for this heightened risk is a public health priority. This study examined relationships between sexual orientation discrimination and DSM-5 AUD severity.

Methods: The 2012 to 2013 National Epidemiologic Survey on Alcohol and Related Conditions III conducted in-person interviews with a nationally representative sample of U. Read More

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http://dx.doi.org/10.1111/acer.13960DOI Listing
February 2019
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Gene Polymorphism and Their Risk Association With Type 2 Diabetes Mellitus.

Open Access Maced J Med Sci 2019 Jan 11;7(1):33-37. Epub 2018 Dec 11.

Department of Biotechnology, Jamia Millia Islamia, University, New Delhi, India.

Background: C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.

Aim: The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls.

Methods: Present study was done by allele specific PCR method to study the gene polymorphism in study subjects. Read More

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http://dx.doi.org/10.3889/oamjms.2019.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352458PMC
January 2019
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Healthy behavioral choices and cancer screening in persons living with HIV/AIDS are different by sex and years since HIV diagnosis.

Cancer Causes Control 2019 Feb 9. Epub 2019 Feb 9.

Department of Epidemiology, College of Public Health and Health Professions, College of Medicine, University of Florida, 2004 Mowry Road, PO Box 100321, Gainesville, FL, 32610-0231, USA.

Purpose: The prevalence of non-AIDS-related malignancies is on the rise among people aging with HIV population, but the evidence on healthy behaviors including cancer screening practices in this population subgroup is extremely limited. Therefore, we investigated the prevalence of healthy behaviors and sex-specific cancer screening among persons living with HIV, by sex and time since HIV diagnosis.

Methods: We included 517 persons living with HIV from the Florida Cohort. Read More

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http://dx.doi.org/10.1007/s10552-019-1135-3DOI Listing
February 2019
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Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder.

Physiol Behav 2019 Feb 7. Epub 2019 Feb 7.

Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Bethesda, MD, USA; Center on Compulsive Behaviors, National Institutes of Health, Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA. Electronic address:

Alcohol use disorder (AUD) is a leading cause of morbidity and mortality worldwide. However, treatment options, including pharmacotherapies, are limited in number and efficacy. Accumulating evidence suggests that elements of the gut-brain axis, such as neuroendocrine pathways and gut microbiome, are involved in the pathophysiology of AUD and, therefore, may be investigated as potential therapeutic targets. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.008DOI Listing
February 2019
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Predisposing factors of necrotizing fasciitis with comparison to cellulitis in Taiwan: A nationwide population-based case-control study.

J Formos Med Assoc 2019 Feb 6. Epub 2019 Feb 6.

Division of Plastic Surgery, Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan. Electronic address:

Background: Necrotizing fasciitis (NF) is a life-threatening soft tissue infection with low incidence that requires prompt surgery. In the initial stage, it is difficult to distinguish NF and cellulitis, and limited population-based reports are available.

Methods: We queried inpatient data sets of National Health Institute Research Database in Taiwan from 2002 to 2011 for all patients with diagnoses of NF. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.01.014DOI Listing
February 2019
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Early Sexual Trauma Exposure and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Theta Oscillations During a Go/No-Go Task.

J Am Acad Child Adolesc Psychiatry 2019 Feb 20;58(2):242-255.e2. Epub 2018 Dec 20.

State University of New York Downstate Medical Center, Brooklyn, NY.

Objective: Trauma, particularly when experienced early in life, can alter neurophysiologic and behavioral development, thereby increasing risk for substance use disorders and related psychopathology. However, few studies have empirically examined trauma using well-characterized developmental samples that are followed longitudinally.

Method: The association of assaultive, non-assaultive, and sexual assaultive experiences before 10 years of age with developmental trajectories of brain function during response inhibition was examined by measuring electrophysiologic theta and delta oscillations during no-go and go conditions in an equal probability go/no-go task. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567183205
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http://dx.doi.org/10.1016/j.jaac.2018.07.905DOI Listing
February 2019
3 Reads

Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism.

Neuropsychopharmacology 2019 Jan 30. Epub 2019 Jan 30.

The Endocrine Program, Department of Animal Sciences, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Growing evidence has shown that developmental alcohol exposure induces central nervous system inflammation and microglia activation, which may contribute to long-term health conditions, such as fetal alcohol spectrum disorders. These studies sought to investigate whether neonatal alcohol exposure during postnatal days (PND) 2-6 in rats (third trimester human equivalent) leads to long-term disruption of the neuroimmune response by microglia. Exposure to neonatal alcohol resulted in acute increases in activation and inflammatory gene expression in hypothalamic microglia including tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6). Read More

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http://dx.doi.org/10.1038/s41386-019-0326-7DOI Listing
January 2019
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Increased alcohol-drinking induced by manipulations of mGlu5 phosphorylation within the bed nucleus of the stria terminalis.

J Neurosci 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychological and Brain Sciences, the Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106-9660, U.S.A.

The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we employed a combination of immunoblotting, neuropharmacological and transgenic procedures to investigate the role for metabotropic glutamate receptor 5 (mGlu5) signaling within the BNST in excessive drinking. We discovered that mGlu5 signaling in the BNST is linked to excessive alcohol consumption in a manner distinct from behavioral or neuropharmacological endophenotypes that have been previously implicated as triggers for heavy drinking. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1909-18.2018DOI Listing
February 2019
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Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.

Biol Psychiatry 2018 Dec 20. Epub 2018 Dec 20.

Laboratory of Fear and Anxiety Disorders, Institutes of Life Science, Nanchang University, Nanchang, China; Department of Neurology, Second Affiliated Hospital, Nanchang University, Nanchang, China. Electronic address:

Background: The role of the amygdala in mediating stress coping has been long appreciated. However, basolateral amygdala (BLA) projection neurons (PNs) are organized into discrete output circuits, and it remains unclear whether stress differentially impacts these circuits.

Methods: Mice were exposed to acute restraint stress or chronic restraint stress (CRS), and c-fos expression was measured as a proxy for neuronal activation in Retrobead retrogradely labeled dorsomedial prefrontal cortex-targeting PNs (BLA→dmPFC) and non-dmPFC-targeting PNs (BLA↛dmPFC). Read More

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http://dx.doi.org/10.1016/j.biopsych.2018.12.010DOI Listing
December 2018
1 Read

Higher Mass Accuracy MALDI-TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's Disease.

Curr Protoc Mol Biol 2019 Feb 8:e86. Epub 2019 Feb 8.

Proteomics Core Facility, University of Technology Sydney, Ultimo, New South Wales, Australia.

Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) is a well-established technique for elucidating the location and relative abundance of a range of biomolecules. More recently, research into this technique has shifted from simple discovery and demonstration of utility to application in biomedical research. Here, we describe a protocol utilizing MALDI-IMS for the spatial mapping of lipids in brain tissue from normal human brains and brains from patients with Alzheimer's disease, in the context of Alzheimer's disease. Read More

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http://dx.doi.org/10.1002/cpmb.86DOI Listing
February 2019
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Assessment of Skin Blood Flow Following Acute Intravenous Alcohol, and Association with Subjective Perceptions, in Social Drinkers.

Alcohol Clin Exp Res 2019 Feb 8. Epub 2019 Feb 8.

National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.

Background: The objective of this study was to determine the effect of acute intravenous (IV) alcohol infusion on skin blood flow (SBF) response, measured at fingertip and earlobe, and subjective responses associated with SBF in social drinkers.

Methods: Twenty-four social drinkers underwent a computer-assisted alcohol self-infusion study. SBF was measured continuously using laser Doppler flow meter, with the probe placed on the fingertip or earlobe. Read More

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http://dx.doi.org/10.1111/acer.13962DOI Listing
February 2019
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Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum.

Neuropsychopharmacology 2019 Feb 7. Epub 2019 Feb 7.

Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA.

Dopaminergic modulation of corticostriatal transmission is critically involved in reward-driven behaviors. This modulation is mainly mediated by dopamine D1 receptors (D1Rs) and D2Rs, which are highly expressed in medium spiny neurons (MSNs) of the dorsomedial striatum (DMS), a brain region essential for goal-directed behaviors and addiction. D1Rs and D2Rs are also present at presynaptic cortical terminals within the DMS. Read More

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http://dx.doi.org/10.1038/s41386-019-0332-9DOI Listing
February 2019
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Effects of APOE on cognitive aging in community-dwelling older adults.

Neuropsychology 2019 Feb 7. Epub 2019 Feb 7.

Department of Family Medicine and Public Health.

Objective: The apolipoprotein E (APOE) gene is an established risk factor for sporadic Alzheimer's disease, with elevated risk for ε4-carriers and reduced risk for ε2-carriers. However, it is unclear whether APOE modifies risk for cognitive decline in normal aging. The objective of this study was to determine whether ε2 and ε4 are associated with rates of normal cognitive aging, and whether associations of ε4 with cognitive decline are modified by sex, education or health behaviors (exercise, alcohol consumption, smoking). Read More

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http://dx.doi.org/10.1037/neu0000501DOI Listing
February 2019
2 Reads

The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders.

Transl Psychiatry 2019 Feb 6;9(1):34. Epub 2019 Feb 6.

Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Adolescent alcohol drinking is known to contribute to the development and severity of alcohol use disorders (AUDs) later in adulthood. Recent studies have shown that long non-coding RNAs (lncRNAs) are critical for brain development and synaptic plasticity. One such lncRNA is natural occurring brain-derived neurotrophic factor antisense (BDNF-AS) that has been shown to regulate BDNF expression. Read More

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http://dx.doi.org/10.1038/s41398-019-0367-zDOI Listing
February 2019
2 Reads

Screening for Adolescent Alcohol Use in the Emergency Department: What Does It Tell Us About Cannabis, Tobacco, and Other Drug Use?

Subst Use Misuse 2019 Feb 6:1-10. Epub 2019 Feb 6.

a The Warren Alpert Medical School of Brown University, Departments of Psychiatry and Human Behavior, Pediatrics, Emergency Medicine, Providence, Rhode Island, USA.

Background: The pediatric emergency department (PED) represents an opportune time for alcohol and drug screening. The National Institute of Alcohol Abuse and Alcoholism (NIAAA) recommends a two-question alcohol screen for adolescents as a predictor of alcohol and drug misuse.

Objective: A multi-site PED study was conducted to determine the association between the NIAAA two-question alcohol screen and adolescent cannabis use disorders (CUD), cigarette smoking, and lifetime use of other drugs. Read More

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http://dx.doi.org/10.1080/10826084.2018.1558251DOI Listing
February 2019
2 Reads

Hazardous Alcohol Consumption and the Risk of Hearing Impairment in Adults Based on the Korean National Health and Nutrition Survey: A Retrospective Study.

J Audiol Otol 2019 Feb 8. Epub 2019 Feb 8.

Department of Otorhinolaryngology, Jeju National University College of Medicine, Jeju, Korea.

Background And Objectives: To investigate the relationship between hearing impairment and alcohol drinking patterns in South Korean adults.

Subjects And Methods: Data collection was performed by Korean National Health and Nutrition Survey from January 1 to December 31, 2012. Data analyses were performed from February 20 to March 3, 2018. Read More

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http://dx.doi.org/10.7874/jao.2018.00241DOI Listing
February 2019
1 Read

NMDA receptor deletion on dopamine neurons disrupts visual discrimination and reversal learning.

Neurosci Lett 2019 Feb 3;699:109-114. Epub 2019 Feb 3.

Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.

The dopamine (DA) system is critical for various forms of learning about salient environmental stimuli. Prior work has shown that deletion of the obligatory NR1 subunit of the N-methyl--aspartate (NMDA) receptor on neurons expressing the DA transporter (DAT) in mice results in reduced phasic release from DA-containing neurons. To further investigate the contribution of phasic DA release to reward-related learning and cognitive flexibility, the current study evaluated DAT-NR1 null mutant mice in a touchscreen-based pairwise visual discrimination and reversal learning paradigm. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.02.001DOI Listing
February 2019
1 Read

Novel kappa opioid receptor agonist as improved PET radiotracer: Development and in vivo evaluation.

Mol Pharm 2019 Feb 6. Epub 2019 Feb 6.

The kappa opioid receptor (KOR) is involved in depression, alcoholism and drug abuse. The current agonist radiotracer C-GR103545 is not ideal for imaging KOR due to its slow tissue kinetics in human. The aim of our project was to develop novel KOR agonist radiotracers with improved imaging properties. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01209DOI Listing
February 2019
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The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063).

AIDS Behav 2019 Feb 6. Epub 2019 Feb 6.

Department of Psychology, University of Miami, Coral Gables, FL, USA.

The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. Read More

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http://link.springer.com/10.1007/s10461-019-02415-w
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http://dx.doi.org/10.1007/s10461-019-02415-wDOI Listing
February 2019
3 Reads

Ethanol induces skin hyperpigmentation in mice with aldehyde dehydrogenase 2 deficiency.

Chem Biol Interact 2019 Feb 2;302:61-66. Epub 2019 Feb 2.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.

Alcohol induces various cutaneous changes, such as palmar erythema and jaundice. However, alcohol-induced skin hyperpigmentation due to melanin deposition has not been reported. Aldehyde dehydrogenase 2 (ALDH2), one of 19 human ALDH isozymes, metabolizes endogenous and exogenous aldehydes to their respective carboxylic acids. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.035DOI Listing
February 2019
2 Reads

Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration under Similar Systemic Exposures.

Alcohol Clin Exp Res 2019 Feb 5. Epub 2019 Feb 5.

Section on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.

Objective: To test whether an individual's subjective responses to alcohol are similar when the breath alcohol concentration (BrAC) trajectory resulting from oral administration is matched by intravenous administration.

Background: Individuals perceive the effects of alcohol differently, and the variation is commonly used in research assessing the risk for developing an alcohol use disorder. Such research is supported by both oral and intravenous alcohol administration techniques, and any differences attributable to the route employed should be understood. Read More

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http://dx.doi.org/10.1111/acer.13970DOI Listing
February 2019
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Relation between adaptive function and IQ among youth with histories of heavy prenatal alcohol exposure.

Birth Defects Res 2019 Feb 4. Epub 2019 Feb 4.

Center for Behavioral Teratology and Department of Psychology, San Diego State University, San Diego, California.

Background: Adaptive function and general intellectual function are two important and often correlated domains. While youth with prenatal alcohol exposure frequently demonstrate impairments in both domains, it is not clear whether the relation between these domains is consistent across levels of ability or whether, for example, adaptive function is less affected by intellectual function at higher ability levels. The aim of the current study was to test this relation in youth with and without prenatal alcohol exposure. Read More

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http://dx.doi.org/10.1002/bdr2.1463DOI Listing
February 2019
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Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.

Sci Rep 2019 Feb 4;9(1):1220. Epub 2019 Feb 4.

Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

The endogenous neurosteroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone) has protective activity in animal models of alcoholism, depression, traumatic brain injury, schizophrenia, multiple sclerosis, and Alzheimer's disease that is poorly understood. Because these conditions involve proinflammatory signaling through toll-like receptors (TLRs), we examined the effects of 3α,5α-THP, and pregnenolone on TLR4 activation in both the periphery and the central nervous system (CNS). We used monocytes/macrophages (RAW264. Read More

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http://dx.doi.org/10.1038/s41598-018-37409-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362084PMC
February 2019
2 Reads

Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction.

Transl Psychiatry 2019 Feb 4;9(1):71. Epub 2019 Feb 4.

Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, 92037, USA.

A limited number of genetic variants have been identified in traditional GWAS as risk or protective factors for alcohol use disorders (AUD) and related phenotypes. We herein report whole-genome association and rare-variant analyses on AUD traits in American Indians (AI) and European Americans (EA). We evaluated 742 AIs and 1711 EAs using low-coverage whole-genome sequencing. Read More

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http://www.nature.com/articles/s41398-019-0397-6
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http://dx.doi.org/10.1038/s41398-019-0397-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362044PMC
February 2019
4 Reads

Adolescents' Social Norms across Family, Peer, and School Settings: Linking Social Norm Profiles to Adolescent Risky Health Behaviors.

J Youth Adolesc 2019 Feb 4. Epub 2019 Feb 4.

Human Development and Family Studies, Michigan State University, 552W. Circle Drive, Human Ecology, East Lansing, MI, 48824, USA.

Social norms around adolescent risky health behaviors have been often studied in separate developmental settings (e.g., family norms, peer norms), and little is known regarding the overall patterns of social norms across contexts and how they influence adolescent risky health behaviors. Read More

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http://dx.doi.org/10.1007/s10964-019-00984-6DOI Listing
February 2019

Pack-years of tobacco cigarette smoking as a predictor of spontaneous pain reporting and experimental pain reactivity.

Exp Clin Psychopharmacol 2019 Feb 4. Epub 2019 Feb 4.

Department of Psychology, Syracuse University.

The pack-years formula is a widely used estimate of lifetime tobacco smoking exposure, and greater pack-years have been associated with greater risk of chronic pain development and poorer pain-related outcomes among smokers with chronic pain. The pathophysiology underlying these associations is poorly understood. Regular tobacco smoking exposure may dysregulate homeostatic pain processes, producing an allostatic state of pain facilitation. Read More

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http://dx.doi.org/10.1037/pha0000258DOI Listing
February 2019
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Drinking context and cause of injury: Emergency department studies from 22 countries.

J Subst Use 2018 11;23(3):240-246. Epub 2017 Oct 11.

WHO Collaborating Center for Drug Abuse and Health, China, Central South University, Changsha, China.

Background: It is estimated that up to a third of injuries requiring emergency department admission are alcohol-related. While injuries that are alcohol-related are unsurprising to emergency department staff, less is understood about the precursors to the injury event.

Methods: Using data from representative emergency department injury patients in 22 countries, we examined associations between context of injury (private or public), cause of injury (fall or trip, being stuck/cut/ or burned and violence) and alcohol use. Read More

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https://www.tandfonline.com/doi/full/10.1080/14659891.2017.1
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http://dx.doi.org/10.1080/14659891.2017.1378747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358161PMC
October 2017
3 Reads

Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys.

Dev Psychopathol 2019 Feb 4:1-10. Epub 2019 Feb 4.

Department of Psychology,Brigham Young University,Provo, UT,USA.

Environmental and biological factors contribute to sleep development during infancy. Parenting plays a particularly important role in modulating infant sleep, potentially via the serotonin system, which is itself involved in regulating infant sleep. We hypothesized that maternal neglect and serotonin system dysregulation would be associated with daytime sleep in infant rhesus monkeys. Read More

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http://dx.doi.org/10.1017/S0954579418001359DOI Listing
February 2019
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Bariatric Surgery Significantly Improves the Quality of Sexual Life and Self-esteem in Morbidly Obese Women.

Obes Surg 2019 Feb 2. Epub 2019 Feb 2.

Hôpital de l'Archet, Digestive Center, Centre Hospitalier Universitaire de Nice, Nice, France.

Background: The impact of bariatric surgery (BS) on the sexual functioning of patients is poorly studied. Our aim was to analyze the sexual function, depressive symptoms, and self-esteem of morbidly obese women (MOW) undergoing BS.

Patients And Methods: Quality of sexual life was prospectively evaluated in 43 consecutive MOW (18-50 years) who underwent BS. Read More

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http://dx.doi.org/10.1007/s11695-019-03733-7DOI Listing
February 2019
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Drinking and driving among adults in the United States: Results from the 2012-2013 national epidemiologic survey on alcohol and related conditions-III.

Accid Anal Prev 2019 Jan 31;125:49-55. Epub 2019 Jan 31.

Epidemiology and Biometry Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 6700B Rockledge Dr., Room 2132, Bethesda, MD, United States. Electronic address:

Despite the seriousness of alcohol-impaired driving (A-ID) very few national surveys on reported A-ID have been conducted since the early 2000s. This study examined 12-month prevalences of driver-based A-ID and passenger-based alcohol-related practices in a large representative sample of the U.S. Read More

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http://dx.doi.org/10.1016/j.aap.2019.01.016DOI Listing
January 2019
1 Read