92,306 results match your criteria Alcoholism


Chronic knockdown of the tetraspanin gene CD81 in the mouse nucleus accumbens modulates anxiety and ethanol-related behaviors.

Physiol Behav 2022 Jun 25:113894. Epub 2022 Jun 25.

Division of Biochemistry, Department of Medicine, University of Fribourg, CH-1700, Fribourg, Switzerland.

CD81, a member of the tetraspanin family, plays important roles in many physiological processes, such as cell motility, attachment, and entry. Yet, CD81 functions in the brain remain unclear. In this study, we investigated the effects of CD81 knockdown, using lentiviral vectors (LV), on anxiety- and ethanol-related behaviors. Read More

View Article and Full-Text PDF

Heavy drinking and problem drinking among youth in Uganda: A structural equation model of alcohol marketing, advertisement perceptions and social norms.

Drug Alcohol Rev 2022 Jun 27. Epub 2022 Jun 27.

Centre for Research and Information on Substance Abuse, Uyo, Nigeria.

Introduction: To determine the role of alcohol marketing, perceptions of marketing and social norms on heavy alcohol use and problem drinking among vulnerable youth in Uganda.

Methods: The Kampala Youth Survey is a cross-sectional study conducted in 2014 with service-seeking youth (ages 12-18 years) living in the slums of Kampala (n = 1134) who were participating in Uganda Youth Development Link drop-in centres. Survey measures assessed perceptions of alcohol advertisements, social norms regarding alcohol use, heavy alcohol use and problem drinking. Read More

View Article and Full-Text PDF

Consideration of sex and gender differences in addiction medication response.

Biol Sex Differ 2022 Jun 27;13(1):34. Epub 2022 Jun 27.

Medical University of South Carolina, Charleston, USA.

Substance use continues to contribute to significant morbidity and mortality in the United States, for both women and men, more so than another other preventable health condition. To reduce the public health burden attributable to substances, the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism have identified that medication development for substance use disorder is a high priority research area. Furthermore, both Institutes have stated that research on sex and gender differences in substance use medication development is a critical area. Read More

View Article and Full-Text PDF

Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder.

Mech Ageing Dev 2022 Jun 24:111693. Epub 2022 Jun 24.

Alcoholism Unit, Department of Internal Medicine, University Hospital of Salamanca, Salamanca, Spain; Institute of Biomedical Research of Salamanca-IBSAL, Salamanca, Spain; Molecular Medicine Unit, Department of Medicine, University of Salamanca, Salamanca, Spain. Electronic address:

Telomere shortening is usually considered a biomarker of ageing. Harmful alcohol use promotes accelerated biological ageing and alcohol use disorders (AUDs) are associated with short telomere length (TL). This study was conducted to examine the relationship of TL to AUD and determine whether single nucleotide polymorphisms (SNPs) in TERC and TERT modulate this association. Read More

View Article and Full-Text PDF

Compounding Vulnerability in the Neurocircuitry of Addiction: Longitudinal Functional Connectivity Changes in Alcohol Use Disorder.

Alcohol Alcohol 2022 Jun 28. Epub 2022 Jun 28.

Clinical NeuroImaging Research Core, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, MSC 1108, Bethesda, MD 20892, USA.

Aims: The addiction neurocircuitry model describes the role of several brain circuits (drug reward, negative emotionality and craving/executive control) in alcohol use and subsequent development of alcohol use disorder (AUD). Human studies examining longitudinal change using resting-state functional magnetic resonance imaging (rs-fMRI) are needed to understand how functional changes to these circuits are caused by or contribute to continued AUD.

Methods: In order to characterize how intrinsic functional connectivity changes with sustained AUD, we analyzed rs-fMRI data from individuals with (n = 18; treatment seeking and non-treatment seeking) and without (n = 21) AUD collected on multiple visits as part of various research studies at the NIAAA intramural program from 2012 to 2020. Read More

View Article and Full-Text PDF

Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder.

Authors:
Falk W Lohoff

Front Psychiatry 2022 9;13:767506. Epub 2022 Jun 9.

Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, United States.

Alcohol Use Disorder (AUD) is a chronic psychiatric disorder marked by impaired control over drinking behavior that poses a significant challenge to the individual, their community, the healthcare system and economy. While the negative consequences of chronic excessive alcohol consumption are well-documented, effective treatment for AUD and alcohol-associated diseases remains challenging. Cognitive and behavioral treatment, with or without pharmaceutical interventions, remain the most commonly used methods; however, their efficacy is limited. Read More

View Article and Full-Text PDF

Mechanisms of Association Between Paternal Alcoholism and Abuse of Alcohol and Other Illicit Drugs Among Adolescents.

J Child Adolesc Subst Abuse 2013 7;22(2):133-149. Epub 2013 Feb 7.

Florida International University, Miami, FL, USA.

The current study examines the effect of paternal alcohol problems on adolescent use of alcohol and other illicit drugs as a function of maternal communication, as well as adolescent social and coping skills ( = 145). Structural equation modeling (SEM) analyses indicated that adolescents with a paternal history of alcohol problems reported higher levels of problematic communication with their mothers than did adolescents with fathers who were light drinkers or who were non-drinkers. Moreover, problematic maternal communication functioned as a partial mediator for both adolescent negative social skills and self-blame coping skills. Read More

View Article and Full-Text PDF
February 2013

Increased Voluntary Alcohol Consumption in Mice Lacking GABA Is Associated With Functional Changes in Hippocampal GABA Receptors.

Front Behav Neurosci 2022 9;16:893835. Epub 2022 Jun 9.

Department of Life and Environment Sciences, Section of Neuroscience and Anthropology, University of Cagliari, Cagliari, Italy.

Gamma-aminobutyric acid type B receptor (GABAR) has been extensively involved in alcohol use disorders; however, the mechanisms by which this receptor modulates alcohol drinking behavior remain murky. In this study, we investigate alcohol consumption and preference in mice lacking functional GABAR using the 2-bottle choice paradigm. We found that GABA, knockout (KO), and heterozygous (HZ) mice drank higher amounts of an alcoholic solution, preferred alcohol to water, and reached higher blood alcohol concentrations (BACs) compared to wild-type (WT) littermates. Read More

View Article and Full-Text PDF

Pulmonary Infection: Case Report and Review of the Literature.

Front Med (Lausanne) 2022 10;9:916817. Epub 2022 Jun 10.

Department of Pulmonary and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Background: Pulmonary actinomycosis (PA), a chronic indolent infection, is a diagnostic challenge. is a relatively rare Actinomyces species isolated from various clinical samples.

Case Presentation: A 47-year-old patient presented with a 3-month history of mucopurulent expectoration and dyspnea and a 3-day history of fever up to 39. Read More

View Article and Full-Text PDF

Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.

Addict Biol 2022 Jul;27(4):e13182

Department of Psychology, University of California at Los Angeles, Los Angeles, California, USA.

Ibudilast, a neuroimmune modulator, shows promise as a pharmacotherapy for alcohol use disorder (AUD). In vivo administration of ibudilast reduces the expression of pro-inflammatory cytokines in animal models, but its effects on markers of inflammation in humans are unknown. This preliminary study examined the effect of ibudilast on peripheral and potential central markers of inflammation in individuals with AUD. Read More

View Article and Full-Text PDF

Implicit measures of alcohol approach and drinking identity in alcohol use disorder: A preregistered double-blind randomized trial with cathodal transcranial direct current stimulation (tDCS).

Addict Biol 2022 Jul;27(4):e13180

Department of Psychiatry and Psychotherapy, Brain Stimulation Center, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen, Germany.

Alcohol use disorder (AUD) is a severe and widespread mental disorder with a huge negative impact on the social, economic and health dimensions. The identification of risk factors for the development of AUD and for relapse in existing AUD are crucial for prevention and treatment approaches. Alcohol-related implicit associations have been shown to contribute to drinking and might partially explain sudden relapses. Read More

View Article and Full-Text PDF

Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats.

Addict Biol 2022 Jul;27(4):e13178

Department of Pharmacology and Experimental Therapeutics, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA.

Alcohol dependence results in long-lasting neuroadaptive changes in meso-corticolimbic system, especially in the nucleus accumbens (NAc), which drives relapse-like ethanol drinking upon abstinence or withdrawal. Within NAc, altered glutamate homeostasis is one of the neuroadaptive changes caused by alcohol dependence. Accumbal glutamate homeostasis is tightly maintained through glutamate transporter 1 (GLT-1) and cystine-glutamate antiporter (xCT). Read More

View Article and Full-Text PDF

Mapping frontoinsular cortex from diffusion microstructure.

Cereb Cortex 2022 Jun 27. Epub 2022 Jun 27.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, United States.

We developed a novel method for mapping the location, surface area, thickness, and volume of frontoinsular cortex (FI) using structural and diffusion magnetic resonance imaging. FI lies in the ventral part of anterior insular cortex and is characterized by its distinctive population von Economo neurons (VENs). Functional neuroimaging studies have revealed its involvement in affective processing, and histopathology has implicated VEN loss in behavioral-variant frontotemporal dementia and chronic alcoholism; however, structural neuroimaging of FI has been relatively limited. Read More

View Article and Full-Text PDF

Longitudinal assessment of drinking changes during the pandemic: The 2021 COVID-19 follow-up study to the 2019 to 2020 National Alcohol Survey.

Alcohol Clin Exp Res 2022 Jun;46(6):1050-1061

Alcohol Research Group, Public Health Institute, Emeryville, California, USA.

Background: Surveys of changes in drinking during the COVID-19 pandemic have primarily relied on retrospective self-report. Further, most such surveys have not included detailed measures of alcohol use patterns, such as beverage-specific consumption, nor measures of alcohol use disorder (AUD) symptoms that would allow a comprehensive understanding of changes in alcohol use.

Methods: Data from 1819 completed interviews from the N14C follow-up survey to the 2019 to 2020 National Alcohol Survey (N14) were conducted between January 30 and March 28, 2021. Read More

View Article and Full-Text PDF

Destigmatizing alcohol use disorder among nurses.

Authors:
Jill Rathburn

Nursing 2022 Jul;52(7):23-29

Jill Rathburn is a board-certified recovery coach and holistic health nurse.

Abstract: The use of alcohol to cope with work-related stress is an increasing problem among nurses. However, barriers to diagnosis and treatment keep nurses with alcohol use disorder (AUD) from getting the help they need. This article discusses the issues and treatment obstacles affecting AUD among nurses, and outlines compassionate, stigma-free paths forward. Read More

View Article and Full-Text PDF

Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: molecular links between the SNHG16 locus and catecholamine metabolism.

Mol Metab 2022 Jun 22:101534. Epub 2022 Jun 22.

Department of Molecular Pharmacology and Experimental Therapeutics; Mayo Clinic; Rochester, Minnesota, USA. Electronic address:

Objective: Alcohol consumption can increase circulating levels of fibroblast growth factor 21 (FGF21). The effects of FGF21 in the central nervous system are associated with the regulation of catecholamines, neurotransmitters that play a crucial role in reward pathways. This study aims to identify genetic variants associated with FGF21 levels and evaluate their functional role in alcohol use disorder (AUD). Read More

View Article and Full-Text PDF

Mutation of the α5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption.

Neuropharmacology 2022 Jun 22:109170. Epub 2022 Jun 22.

Pharmacology Graduate Group, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Alcohol and nicotine are commonly used during adolescence, establishing long-lasting neuroplastic alterations that influence subsequent drug use and abuse. Drinking- and smoking-related traits have been extensively associated with variation in CHRNA5 - the gene that encodes the α5 subunit of neuronal nicotinic acetylcholine receptors (nAChRs). The single nucleotide polymorphism (SNP) rs16969968 in CHRNA5 encodes an amino acid substitution (D398N) that alters the function and pharmacokinetics of α5-containing nAChR. Read More

View Article and Full-Text PDF

Necrotizing Fasciitis In A Patient with Metastatic Clear Cell Ovarian Carcinoma Treated with Bevacizumab.

Am J Case Rep 2022 Jun 25;23:e935584. Epub 2022 Jun 25.

Department of Internal Medicine, BronxCare Hospital, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Necrotizing fasciitis is a life-threatening infection of the deep soft tissues that leads to progressive destruction of the fascia and subcutaneous fat. It typically spreads along the muscle fascia planes because of the relatively poor blood supply. Muscle tissue is usually spared because of its better blood supply. Read More

View Article and Full-Text PDF

Prior test experience confounds longitudinal tracking of adolescent cognitive and motor development.

BMC Med Res Methodol 2022 Jun 24;22(1):177. Epub 2022 Jun 24.

Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine (MC5723), 401 Quarry Road, Stanford, CA, 94305-5723, USA.

Background: Accurate measurement of trajectories in longitudinal studies, considered the gold standard method for tracking functional growth during adolescence, decline in aging, and change after head injury, is subject to confounding by testing experience.

Methods: We measured change in cognitive and motor abilities over four test sessions (baseline and three annual assessments) in 154 male and 165 female participants (baseline age 12-21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) study. At each of the four test sessions, these participants were given a test battery using computerized administration and traditional pencil and paper tests that yielded accuracy and speed measures for multiple component cognitive (Abstraction, Attention, Emotion, Episodic memory, Working memory, and General Ability) and motor (Ataxia and Speed) functions. Read More

View Article and Full-Text PDF

Cardiovascular and metabolic changes in Brazilian truck drivers.

J Vasc Nurs 2022 Jun 23;40(2):112-116. Epub 2022 May 23.

Faculdade de Medicina, Universidade Federal de Uberlândia, Campus Umuarama - Bloco 2U, Brazil. Electronic address:

Objective: To identify the relationship between the Ankle Brachial Index (ABI) and the presence of cardio-metabolic diseases, alcohol, and tobacco abuse among truck drivers.

Methods: This is a cross-sectional study with a quantitative approach carried out with 235 truck drivers. Demographic, professional, clinical, alcohol, and tobacco abuse data were collected through interviews. Read More

View Article and Full-Text PDF

Changes in Alcohol Consumption by Beverage Type Attributable to the COVID-19 Pandemic for 10 States, March 2020 to November 2020: An Ecological Simulation-based Analysis.

J Addict Med 2022 Jun 25. Epub 2022 Jun 25.

From the Department of Medicine, School of Medicine, Johns Hopkins University Baltimore, MD (JDP, GC); National Clinician Scholars Program at the Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (APT); Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (EC).

Objectives: Consumption of high potency alcohol is associated with greater healthcare burden, yet little attention has been placed on the change in types of alcohol consumed during the COVID-19 pandemic. We estimate the change in alcohol consumption by beverage type attributable to the COVID-19 pandemic.

Methods: The National Institute on Alcohol Abuse and Alcoholism provided apparent alcohol consumption ("consumption") by beverage type for 10 states for January 2017 through November 2020 based on sales and tax data. Read More

View Article and Full-Text PDF

Transcription factor p8 regulates autophagy in response to disulfiram via PI3K/mTOR/p70S6K signaling pathway in pancreatic cancer cells.

Hum Cell 2022 Jun 24. Epub 2022 Jun 24.

Key Laboratory of Antibody Technology, National Health Commission, Nanjing Medical University, 101 Longmian Road, Nanjing, 211166, Jiangsu, China.

Disulfiram (DSF), which is an inhibitor of aldehyde dehydrogenase (ALDH) and approved by the FDA for the treatment of alcoholism previously, has been repurposed for use as a cancer treatment because of its potent effect in preclinical studies. In this study, we found that disulfiram forms potent complexes with copper (DSF/Cu) inhibited cell proliferation, induced apoptosis in human pancreatic cancer cells, which was detected by flow cytometry and western blotting. Meanwhile, autophagy and autophagic flux also clearly observed by transmission electron microscopy, confocal microscopy and flow cytometry. Read More

View Article and Full-Text PDF

The Mineralocorticoid Receptor: An Emerging Pharmacotherapeutic Target for Alcohol Use Disorder?

ACS Chem Neurosci 2022 Jun 24. Epub 2022 Jun 24.

Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, Maryland 21224, United States.

Despite the high prevalence and negative consequences associated with alcohol use disorder (AUD), currently available pharmacotherapies are limited in number and efficacy. Several neuroendocrine pathways have been identified and are under investigation as potential pharmacotherapeutic targets for AUD. Here, we present the promise of the mineralocorticoid receptor (MR) as a novel target and discuss associations between the aldosterone/MR system and AUD, the effects of MR antagonism on alcohol consumption, and the underlying neurobiology of these effects. Read More

View Article and Full-Text PDF

SURPRISINGLY FEW WOMEN WITH SEVERE OSTEOPOROSIS BY BONE DENSITOMETRY UNDERGO WORKUP FOR SECONDARY CAUSES - A RETROSPECTIVE EVALUATION.

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):537-542

University of California San Diego, La Jolla, California, United States of America.

We describe clinical features of women with extremely low bone density, and investigate secondary causes of osteoporosis. Our hypothesis was that this population would be enriched in identifiable causes of osteoporosis. We performed a retrospective review of medical records of all women seen at our university over 4 years with T-score on bone densitometry at/below -4 at any site. Read More

View Article and Full-Text PDF

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L.

Pharmaceuticals (Basel) 2022 Jun 13;15(6). Epub 2022 Jun 13.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

One inhibitor of the main SARS-CoV-2 protease has been approved recently by the FDA, yet it targets only SARS-CoV-2 main protease (Mpro). Here, we discovered inhibitors containing thiuram disulfide or dithiobis-(thioformate) tested against key proteases involved in SARS-CoV-2 replication, including Mpro, SARS-CoV-2 papain-like protease (PLpro), and human cathepsin L. The use of thiuram disulfide and dithiobis-(thioformate) covalent inhibitor warheads was inspired by an idea to find a better alternative than disulfiram, an approved treatment for chronic alcoholism that is currently in phase 2 clinical trials against SARS-CoV-2. Read More

View Article and Full-Text PDF

Subcutaneous and Intraosseous Fat Necrosis Associated with Chronic Pancreatitis.

Medicina (Kaunas) 2022 Jun 14;58(6). Epub 2022 Jun 14.

Digestive Surgery Clinic, University Clinical Center Nis, University of Nis, 18000 Nis, Serbia.

Extra-abdominal manifestations of fat necrosis, like subcutaneous fat necrosis, polyarthritis, and polyserositis may appear with an occurrence rate of about 0.8%, wherein intraosseous fat necrosis is a more rare complication of pancreatitis, with few reports in English literature. A 34-year-old male with a 15-year-history of alcohol abuse was hospitalized several times in the last few years because of attacks of relapsed chronic pancreatitis. Read More

View Article and Full-Text PDF

Alcohol Abuse Associated with Accumulated Periods of Precarious Employment: A Four-Year Follow-Up Study of a Young Population in Korea.

Int J Environ Res Public Health 2022 Jun 16;19(12). Epub 2022 Jun 16.

Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Korea.

This study aims to explore how precarious employment among young age groups affects alcohol-use disorders. Using samples from Youth Panel 2007, a longitudinal and annual follow-up survey, the association between alcohol-use disorder assessed with CAGE and the accumulated years of precarious employment was assessed with logistic regression analysis. During the 4-year follow-up period, precarious employment for 2-4 years (OR 2. Read More

View Article and Full-Text PDF

Association between Bar Closing Time, Alcohol Use Disorders and Blood Alcohol Concentration: A Cross-Sectional Observational Study of Nightlife-Goers in Perth, Australia.

Int J Environ Res Public Health 2022 Jun 8;19(12). Epub 2022 Jun 8.

National Drug Research Institute and enAble Institute, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia.

Introduction And Aims: Associations between bar trading hours, a government lever for controlling alcohol availability, nightlife-goer intoxication levels and their likelihood of alcohol use disorder (AUD) have not been explored. We investigated whether: (i) participant AUD was associated with blood alcohol concentration (BAC); and, (ii) any association between AUD and BAC was moderated by participant preferred bar (i.e. Read More

View Article and Full-Text PDF