Search Our Scientific Publications & Authors

Cell Physiol Biochem 2018 Dec 6;51(5):2123-2135. Epub 2018 Dec 6.

Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou,

Background/aims: Emerging evidence suggests a close link between gut microbiota and non-alcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the association between gut microbiota and the DNA methylation of adiponectin (an adipocyte-specific adipocytokine) in rats, following diet-induced NAFLD.

Methods: 50 male SD rats were randomly divided into five groups with or without a high fat diet (HFD), antibiotics, and probiotics, in order to establish an imbalanced gut microbiota and probiotic treatment model in NAFLD rats. Read More

Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.

Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More

PLoS One 2018 6;13(12):e0208427. Epub 2018 Dec 6.

Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, United States of America.

Background: Type 2 diabetes is often linked with impaired proximal insulin signaling. Hence, a therapeutic agent that enhances cellular glucose uptake without requiring proximal insulin signaling would be desirable for improving glycemic control. The E4orf1 peptide (E4) derived from human adenovirus 36 (Ad36) promotes cellular glucose uptake in vitro and in vivo, independent of insulin. Read More

Free Radic Biol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmaceutical Science, University of Perugia, Perugia, Italy. Electronic address:

Lipid peroxidation is one of the earliest pathogenic events of non-alcoholic fatty liver disease (NAFLD). In this context, an increased oxidation of the lipoperoxyl radical scavenger α-tocopherol (α-TOH) should occur already in the subclinical phases of the disease to compensate for the increase oxidation of the lipid excess of liver and possibly of other tissues. However, this assumption remains unsupported by direct analytical evidence. Read More

J Consult Clin Psychol 2018 Dec;86(12):1005-1016

Salus Clinic Lindow.

Objective: Alcohol-dependent patients show attentional and approach biases for alcohol-related stimuli. Computerized cognitive bias modification (CBM) programs aim to retrain these biases and reduce relapse rates as add-ons to treatment. Retraining of alcohol-approach tendencies has already yielded significant reductions of relapse rates in previous studies, and retraining of biased attention toward alcohol is promising approach. Read More

Liver Int 2018 Dec 2. Epub 2018 Dec 2.

Dept. of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Th17 cells mediated immune response is important in chronic hepatitis B (CHB) infection and inflammation associated diseases, however, little is known about their immunopathogenic role in acute-on-chronic liver failure (ACLF). Interleukin-23 receptor (IL-23R) is essential for the generation of pathogenic Th17 cells, therefore, we aimed to evaluate IL-23R expression and its correlation with disease severity in ACLF.

Methods: Forty two patients with ACLF (HBV and alcohol-related), thirty two with CHB and twenty healthy controls (HC) were studied. Read More

Methods Mol Biol 2019 ;1887:119-127

Department of Food Management, Miyagi University, Sendai, Miyagi, Japan.

Hydroxyl fatty acids (HFAs) are used in widely diverse industrial applications, healthy functional foods, artificial food flavorings, and alcoholic beverages. A lactic acid bacterium (LAB), Lactobacillus sakei, hydroxylates oleic acid. Furthermore, the hydroxyl fatty acid was identified by GC-MS as 10-hydroxystearic acid. Read More

Front Pediatr 2018 16;6:345. Epub 2018 Nov 16.

Department of Pediatrics, Johns Hopkins Medicine, All Children's Hospital, St. Petersburg, FL, United States.

Carotid intima media thickness (cIMT) and brachial flow-mediated dilation (FMD) evaluated by ultrasound are non-invasive markers of atherosclerosis. Increased cIMT in adults has been correlated to early vascular damage. Several studies show similar correlations of elevated cIMT in children with obesity, hyperlipidemia, and metabolic syndrome. Read More

Clin Biochem 2018 Nov 29. Epub 2018 Nov 29.

Xi'an Medical University, Xi'an, China. Electronic address:

Objective: To increase the accuracy of non-invasive diagnosis of nonalcoholic fatty liver disease (NAFLD), clinical and laboratory NAFLD indicators were integrated into a diagnostic formula.

Methods: A total of 141 patients with clinically diagnosed NAFLD and 30 healthy controls were enrolled. We collected case history, body weight, height and mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase, blood urea nitrogen and blood uric acid (UA), serum creatinine, plasma total cholesterol, triglyceride, low density lipoprotein, glycosylated hemoglobin, fasting plasma glucose, fasting insulin, ultrasonic tests, Fibroscans, and other data. Read More

Food Chem 2019 Mar 25;277:438-447. Epub 2018 Oct 25.

Centre de Développement Bioalimentaire du Québec, La Pocatière, QC G0R 1Z0, Canada; Department of Food Science, Université Laval, Québec, QC G1V 0A6, Canada; Department of Science, Université Sainte-Anne, 1695 Rd 1, Church Point, NS B0W 1M0, Canada. Electronic address:

The impact of different factors (must protein treatment: bentonite and heat; pomace: fermented with and without; tannin addition: 0-9 g/L; and time of maceration: 0-11 days) on tannin, pigment, and protein extraction/retention in Frontenac wines was investigated. Wine tannin concentration and composition were determined by HPLC-fluorescence. Protein and pigment parameters were analysed by BCA assay and Boulton's method, respectively, using UV-spectrophotometry. Read More

Food Chem 2019 Mar 19;277:12-24. Epub 2018 Oct 19.

Mevsim Gida Sanayi ve Soguk Depo Ticaret A.S. (MVSM Foods), Turankoy, Kestel, 16540 Bursa, Turkey. Electronic address:

Nowadays, consumers expect to be sure that a food product complies with its label and demand further information regarding the geographical origin of the product. Beverages are among the most likely foods to be the target of food fraud. Adulteration through practices including, among the others, mixing or substituting the original material with other materials or useless parts of the same materials, which do not conform to the official standards and the food label, originate non-authentic beverages. Read More

Toxicol Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.

Human alcoholic hepatitis (AH) carries a high mortality rate. AH is an acute-on-chronic form of liver injury characterized by hepatic steatosis, ballooned hepatocytes, neutrophil infiltration, and pericellular fibrosis. We aimed to study the pathogenesis of AH in an animal model which combines chronic hepatic fibrosis with intragastric alcohol administration. Read More

Salud Colect 2018 Jul-Sep;14(3):579-595

Licenciada en Nutrición, Magíster en Epidemiología, Gestión y Políticas de Salud. Docente adscripta, Universidad de Buenos Aires, Ciudad autónoma de Buenos Aires, Argentina.

With the aim of describing the association between food availability and the mortality rate due to colorectal cancer in the countries of the Americas in 2010, data provided by the International Agency for Research on Cancer and the Food and Agriculture Federation were analyzed in an ecological study. Great variability was observed except in caloric supply. Food availability was abundant for calories, total fats, animal fat, red meat and alcoholic beverages. Read More

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180016. Epub 2018 Nov 29.

Departamento de Vigilância de Doenças e Agravos Não Transmissíveis e Promoção da Saúde, Secretaria de Vigilância em Saúde, Ministério da Saúde - Brasília (DF), Brasil.

Introduction: Land transport accidents (LTA) are the second cause of death in schoolchildren aged 13 to 17 years. The study aims to describe the risk factors for LTA in schoolchildren from the National School Health Survey (PeNSE) of 2015 and to evaluate the trend of selected indicators in the last three editions of PeNSE.

Methodology: A descriptive study on risk factors for LTA in 2015, with PeNSE data and time series trends analysis, with age-adjusted regression tests of the 2009, 2012 and 2015 editions, in Brazilian capitals. Read More

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180002. Epub 2018 Nov 29.

Departamento de Vigilância de Doenças e Agravos não Transmissíveis e Promoção da Saúde, Ministério da Saúde - Brasília (DF), Brasil.

Objective: To analyze trend estimates on the prevalence of risk and protective behaviors for chronic noncommunicable diseases in adolescents, according to data from the National School Health Survey in 2009, 2012 and 2015.

Methods: Data from the three cross-sectional studies in Brazilian capitals and the Federal District were used. In total, 173,310 adolescents enrolled in the ninth grade of elementary school were interviewed, with average age of 14 years. Read More

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, 10021, USA.

In non-alcoholic fatty liver disease (NAFLD), triglycerides accumulate within the liver because the rates of fatty acid accrual by uptake from plasma and de novo synthesis exceed elimination by mitochondrial oxidation and secretion as VLDL-triglycerides. Thioesterase superfamily member 2 (Them2) is an acyl-CoA thioesterase that catalyzes the hydrolysis of fatty acyl-CoAs into free fatty acids plus CoASH. Them2 is highly expressed in the liver, as well as other oxidative tissues. Read More

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine, University of Colorado, Denver Division of Gastroenterology & Hepatology.

Background: A crucial component of non-alcoholic fatty liver disease (NAFLD) pathogenesis is lipid stress, which may contribute to hepatic inflammation and activation of innate immunity in the liver. However, little is known regarding how dietary lipids, including fat and cholesterol, may facilitate innate immune activation in vivo. We hypothesized that dietary fat and cholesterol drive NAFLD progression to steatohepatitis and hepatic fibrosis by altering the transcription and phenotype of hepatic macrophages METHODS: This hypothesis was tested by using RNA-seq methods to characterize and analyze sort-purified hepatic macrophage populations that were isolated from mice fed diets with varying amounts of fat and cholesterol RESULTS: The addition of cholesterol to a high fat diet triggered hepatic pathology reminiscent of advanced non-alcoholic steatohepatitis (NASH) in humans characterized by signs of cholesterol dysregulation, generation of oxidized LDL, increased recruitment of hepatic macrophages, and significant fibrosis. Read More

Georgian Med News 2018 Oct(283):76-80

Higher educational establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The article presents a theoretical generalization of the research results the effectiveness of heparisin on the state of the carbohydrate-protein components of the extracellular matrix of connective tissue in liver in patients with non-alcoholic steatohepatitis with obesity I-II degree and chronic kidney disease І-ІІ stage. The purpose of the study is to find out the effectiveness of heparisin (glycyrizine 40 mg, glycine 400 mg, L-cysteine hydrochloride 20 mg) on the state of the carbohydrate-protein components of the extracellular matrix in connective tissue of the liver in patients with non-alcoholic steatohepatitis (NASH) with obesity I-II degree and chronic kidney disease (CKD) І-ІІ stage. 98 patients with NASH on the background of obesity of the I-II degree were examined, including: 52 patients with NASH (I group) (without accompanying CKD), 46 patients with NASH with comorbid CKD І-ІІ stage (II group). Read More

Hepatology 2018 Dec 4. Epub 2018 Dec 4.

NAFLD Research Center, Division of Gastroenterology, University of California San Diego School of Medicine, San Diego, CA, 92093-0887.

The epidemic of non-alcoholic fatty liver disease (NAFLD) has created a large demand for diagnostic tools to identify patients at risk of disease progression including the development of end-stage liver disease. The prevalence of NAFLD is rising worldwide and it is estimated that approximately 1 billion individuals may be afflicted with NAFLD globally (1). Currently, the gold standard to diagnose advanced fibrosis and therefore the reference for all non-invasive technology is liver histology and it's assessment by an experienced liver-histopathologist. Read More

Hepatol Int 2018 Dec 4. Epub 2018 Dec 4.

Institute of Hepatology London, Foundation for Liver Research, London, UK.

Human precision-cut liver slices represent a robust and versatile ex vivo model which retains the complex and multi-cellular histoarchitecture of the hepatic environment. As such, they represent an ideal model to investigate the mechanisms of liver injury and for the identification of novel therapeutic targets. Schematic overview to highlight the utility of precision-cut liver slices as a relevant and versatile ex-vivo model of liver disease. Read More

Obes Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of General Surgery, National University Health System, 1E, Kent Ridge Road, Singapore, 119228, Singapore.

Purpose: Incidence of non-alcoholic fatty liver disease (NAFLD) is on the rise and is one of the most common causes of chronic liver disease worldwide. Obesity and metabolic syndrome are considered the most significant risk factors. Bariatric surgery is the only treatment modality in morbid obesity which allows long-term weight loss with improvement in associated co-morbid conditions. Read More

Anal Bioanal Chem 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, McGill University Health Center, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada.

Hepatic lipid accumulation, mainly in the form of triglycerides (TGs), is the hallmark of non-alcoholic fatty liver disease (NAFLD). To date, the spatial distribution of individual lipids in NAFLD-affected livers is not well characterized. This study aims to map the triglyceride distribution in normal human liver samples and livers with NAFLD and cirrhosis with imaging mass spectrometry (MALDI IMS). Read More

Occup Environ Med 2018 Dec 4. Epub 2018 Dec 4.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Objectives: Accumulated evidence implies that night shift work may trigger liver dysfunction. Non-alcoholic fatty liver (NAFL) is suggested to be a necessary mediator in this process. This study aimed to examine the relationship between night shift work and elevated level of alanine transaminase (e-ALT) of workers and investigate the potential mediation effect of NAFL. Read More

J Prev Med Public Health 2018 Nov 14;51(6):298-309. Epub 2018 Nov 14.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Objectives: The objective of this study was to assess the relationship between systolic and diastolic blood pressure (SBP, DBP) and the risk of death from specific causes other than cardiovascular diseases.

Methods: We calculated the risk of specific death by SBP and DBP categories for 506 508 health examinees in 2002-2003 using hazard ratios (HRs) and 95% confidence intervals (CIs) in a Cox proportional hazards model.

Results: Compared to normal levels (SBP <120 or DBP <90 mmHg), stage I systolic and diastolic hypertension (SBP 140-159, DBP 85- 89 mmHg, respectively) were associated with an increased risk of death from diabetes mellitus, alcoholic liver disease, and renal failure (HR, 1. Read More

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

General Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Pad. Granelli, via F Sforza 35, 20122 Milan, Italy.

Alcoholic liver disease (ALD), a disorder caused by excessive alcohol consumption is a global health issue. More than two billion people consume alcohol in the world and about 75 million are classified as having alcohol disorders. ALD embraces a wide spectrum of hepatic lesions including steatosis, alcoholic steatohepatitis (ASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Read More

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506, USA.

Apple pomace, which is a waste byproduct of processing, is rich in several nutrients, particularly dietary fiber, indicating potential benefits for diseases that are attributed to poor diets, such as non-alcoholic fatty liver disease (NAFLD). NAFLD affects over 25% of United States population and is increasing in children. Increasing fruit consumption can influence NAFLD. Read More

Biomarkers 2018 Dec 4:1-16. Epub 2018 Dec 4.

a Genetics and Molecular Biology Laboratory, Department of Zoology , University of North Bengal , P.O. NBU , Dist. Darjeeling, 734013 , West Bengal , India.

Context: Pesticide poisoning and related deaths is a global concern, but there is little information about its effect on the occupationally exposed tea garden workers of North Bengal.

Objective: This study investigates the level of AChE and BuChE in the blood of the tea garden workers, at risk of exposure to a mixture of pesticides.

Materials And Methods: The study sample consisted of pesticide exposed workers, non exposed (control), smokers and alcoholics. Read More

J Clin Gastroenterol Hepatol 2018 30;2(3). Epub 2018 Jul 30.

Johns Hopkins University, Baltimore, MD, USA.

Background And Aim: Non-alcoholic fatty liver disease (NAFLD) is common among HIV-infected (HIV+) adults. The Liver Fat Score (LFS) is a non-invasive, rapid, inexpensive diagnostic tool that uses routine clinical data and is validated against biopsy in HIV-uninfected (HIV-) persons. CT liver-to-spleen (L/S) attenuation ratio is another validated method to diagnose NAFLD. Read More

Food Sci Nutr 2018 Nov 25;6(8):2466-2472. Epub 2018 Oct 25.

Centre for Food Science and Nutrition Addis Ababa University Addis Ababa Ethiopia.

Cheka is a cereal and vegetable-based beverage which is consumed in Southwestern parts of Ethiopia particularly in Dirashe and Konso. In this study, nine cheka samples were collected from vending houses in Konso and Dirashe districts for the laboratory analysis of the nutritional profile and chemical properties of cheka. The pH and titratable acidity of the samples ranged from 3. Read More

Food Sci Nutr 2018 Nov 11;6(8):2293-2300. Epub 2018 Oct 11.

Graduate School of International Agricultural Technology Seoul National University Pyeongchang-gun Gangwon-do Korea.

Makgeolli is a traditional Korean alcoholic rice beverage. It is brewed of ingredients containing starch, Nuruk, and water. In order to improve the quality and functionality of Makgeolli, the fermented buckwheat containing 18. Read More

Front Microbiol 2018 19;9:2763. Epub 2018 Nov 19.

Research Group of Industrial Microbiology and Food Biotechnology, Bioengineering Sciences Department, Vrije Universiteit Brussel, Brussels, Belgium.

The present study combined high-throughput culture-dependent plating and culture-independent amplicon sequencing with a metabolite target analysis to systematically dissect the identity, evolution, and role of the microorganisms, substrates, and metabolites during the four-phase fermentation and maturation process of lambic beer production. This led to the following new insights. The changing physicochemical parameters and substrate and metabolite compositions of the fermenting wort and maturing lambic beer provoked several transitions between microbial species and explained the four-step production process. Read More

Exp Mol Med 2018 Dec 3;50(12):157. Epub 2018 Dec 3.

Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China.

Glucagon-like peptide-1 (GLP-1) has a broad spectrum of biological activity by regulating metabolic processes via both the direct activation of the class B family of G protein-coupled receptors and indirect nonreceptor-mediated pathways. GLP-1 receptor (GLP-1R) agonists have significant therapeutic effects on non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. However, clinical studies indicated that GLP-1 treatment had little effect on hepatic steatosis in some NAFLD patients, suggesting that GLP-1 resistance may occur in these patients. Read More

Genetics 2018 Dec 3. Epub 2018 Dec 3.

INRA, Université Paris-Saclay, Université Paris-Sud, CNRS, AgroParisTech

Heterosis (hybrid vigor) and inbreeding depression, commonly considered as corollary phenomena, could nevertheless be decoupled under certain assumptions according to theoretical population genetics works. In order to explore this issue on real data, we analyzed the components of genetic variation in a population derived from a half-diallel cross between strains from and , two related yeast species involved in alcoholic fermentation. A large number of phenotypic traits, either molecular (coming from quantitative proteomics) or related to fermentation and life-history, were measured during alcoholic fermentation. Read More

J Formos Med Assoc 2018 Nov 30. Epub 2018 Nov 30.

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan; Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Huge amount microorganisms resides in human intestine, and many contribute to the maturation and homeostasis of immune system. The diversity of gut ecology are affected by the gestational age, delivery type, feeding sources, and antibiotics use in neonates. Recent studies pointed out that disturbance of gut microbiota, so called dysbiosis, could result in several pediatric diseases including obesity, non-alcoholic fatty liver disease (NAFLD), metabolic syndromes, allergic diseases, and inflammatory bowel diseases. Read More

BMC Genomics 2018 Dec 3;19(1):864. Epub 2018 Dec 3.

Department of Molecular Biology of Animals, National Research Institute of Animal Production, ul Krakowska 1, 32-083 Balice, Cracow, Poland.

Background: Corn dried distillers grains with solubles (cDDGS) are a byproduct of biofuel and alcohol production. cDDGS have been used in pig feed for many years, because they are readily available and rich in protein, fiber, unsaturated fatty acids and phytosterols. However, feed mixtures too high in cDDGS result in the worsening of backfat quality. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13438

Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea.

Recently, modified fibrosis-4 index (mFIB-4) and the easy liver fibrosis test (eLIFT) were developed for predicting liver fibrosis in chronic liver disease patients. We evaluated whether the 2 tests can predict hepatocellular carcinoma (HCC) risk in alcoholic liver cirrhosis (ALC) patients.A retrospective cohort of 924 ALC patients was assessed for HCC development. Read More

Addict Behav 2018 Nov 24;90:312-317. Epub 2018 Nov 24.

Edge Hill University, St Helens Rd, Ormskirk L39 4QP, UK.

Background: Non-problem drinkers attend automatically to alcohol-related cues compared to non-alcohol related cues on tests of inhibitory control. Moreover, attentional bias for alcohol-related cues varies between problem and non-problem drinkers.

Aim: To examine attentional bias towards alcoholic and non-alcoholic appetitive cues between problem and non-problem drinkers. Read More

J Nutr Biochem 2018 Nov 6;64:128-143. Epub 2018 Nov 6.

Department of Physiology, University of Tennessee Health Science Center, 3 Dunlap Street, Suite S303, Memphis, TN 38103. Electronic address:

Recent study indicated that glutamine prevents alcoholic tissue injury in mouse gut and liver. Here we investigated the potential role of Epidermal Growth Factor Receptor (EGFR) in glutamine-mediated prevention of ethanol-induced colonic barrier dysfunction, endotoxemia and liver damage. Wild-type and EGFR*Tg transgenic (expressing dominant negative EGFR) mice were fed 1-6% ethanol in Lieber-DeCarli diet. Read More

FEMS Yeast Res 2018 Nov 30. Epub 2018 Nov 30.

DIPA, PROPAC. Facultad de Química, Universidad Autónoma de Querétaro, C.U. Cerro de las Campanas s/n. Col. Las Campanas, C.P. 76010 Querétaro, Qro., México.

Scheffersomyces stipitis shows a high capacity to ferment xylose, with a strong oxygen dependence to allow NAD+ regeneration. However, without oxygen regeneration of NADH occurs by other metabolic pathways like alcoholic fermentation. There are few reports about inhibitors of mitochondrial respiration and their effects on growth and fermentation. Read More

Endocr Rev 2018 Nov 30. Epub 2018 Nov 30.

ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney NSW, Australia.

The liver and the reproductive system interact in a multifaceted bidirectional fashion. Sex steroid signaling influences hepatic endobiotic and xenobiotic metabolism and contributes to the pathogenesis of functional and structural disorders of the liver. In turn, liver function impacts on the reproductive axis via modulating sex steroid metabolism and transport to tissues via sex hormone binding globulin (SHBG). Read More

PLoS One 2018 30;13(11):e0207479. Epub 2018 Nov 30.

The Liver Unit, Institute of Gastroenterology and Liver Diseases, Department of Medicine, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.

Background And Aim: The progression of non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) is believed to be the driver for future development of fibrosis and cirrhosis. Nevertheless, there remains a clear deficit in non-invasive methods for the diagnosis of NASH. The aim of the present study was to evaluate the prevalence of portal lymphadenopathy (PL) in biopsy- proven NAFLD patients and to determine whether PL correlates with NAFLD stage and severity. Read More

Anal Chem 2018 Nov 30. Epub 2018 Nov 30.

High resolution LC-MS-untargeted lipidomics using data-independent acquisition (DIA) has the potential to increase lipidome coverage as it enables the continuous and unbiased acquisition of all eluting ions. However, the loss of the link between the precursor and the product ions combined with the high dimensionality of DIA data sets hinder accurate feature annotation. Here, we present LipidMS, an R-package aimed to confidently identify lipid species in untargeted LC-DIA-MS. Read More

Dalton Trans 2018 Nov 30. Epub 2018 Nov 30.

School of Molecular and Life Sciences and Curtin Institute for Functional Molecules and Interfaces, Curtin University, Kent Street, Bentley 6102, WA, Australia.

β-Triketonates have been recently used as chelating ligands for lanthanoid ions, presenting unique structures varying from polynuclear assemblies to polymers. In an effort to overcome low solubility of the complexes of tribenzoylmethane, four β-triketones with higher lipophilicity were synthesised. Complexation reactions were performed for each of these molecules using different alkaline bases in alcoholic media. Read More

J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Background: We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.

Methods: To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. Read More

Ann Transl Med 2018 Oct;6(20):411

Division of Gastroenterology, University of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada.

Hepatobiliary Surg Nutr 2018 Oct;7(5):389-391

The Texas Liver Institute, University of Texas (UT) Health San Antonio, San Antonio, TX, USA.

Visc Med 2018 Oct 28;34(5):381-387. Epub 2018 Oct 28.

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Metabolic diseases, comprising type 2 diabetes mellitus (T2DM), dyslipidemia, and non-alcoholic steatohepatitis (NASH), are rapidly increasing worldwide. Conservative medical therapy, including the newly available drugs, has only limited effects and does neither influence survival or the development of micro- or macrovascular complications, nor the progression of NASH to liver cirrhosis, nor the development of hepatocellular carcinomas in the NASH liver. In contrast, metabolic surgery is very effective independent of the preoperative body mass index (BMI) in reducing overall and cardiovascular mortality in patients with T2DM. Read More

Case Rep Gastrointest Med 2018 18;2018:9430701. Epub 2018 Oct 18.

Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

With alcoholic cirrhosis and nonalcoholic fatty liver disease continuously on the rise in the United States, there is also a corresponding rise in portal hypertension. Portal hypertensive duodenopathy (PHD) is a complication of portal hypertension not commonly seen in cirrhotic patients. We present a case of a 46-year-old man who presented with decompensated liver cirrhosis secondary to gastrointestinal bleed. Read More