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J Ethnopharmacol 2020 May 23;260:112999. Epub 2020 May 23.

Clinical Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, 34054, Daejeon, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Dohongsamul-tang (DST) is a traditional herbal formula used to promote the blood circulation and inhibit inflammation, and also widely has been used in the treatment of patients with chronic liver diseases in Korea and China.

Aim Of The Study: This study aimed to investigate the effect of DST on regulation of lipid metabolism of chronic liver diseases in mouse model of non-alcoholic fatty liver diseases (NAFLD).

Materials And Methods: In this study, we evaluated the effect of DST on high-fat and high-cholesterol diet (HFHC, 40% fat and 1% cholesterol)-induced NAFLD, and applied unbiased lipidomics using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF MS) coupled with multivariate analysis. Read More

J Ethnopharmacol 2020 May 12. Epub 2020 May 12.

M. M College of Pharmacy, M. M (Deemed to be University), Mullana, Ambala, Haryana, 133207, India. Electronic address:

Ethnophramacological Relevance: Coriandrum sativum L. is traditionally acknowledged for its use in inflammatory disorders, altered blood lipid levels, respiratory and digestive problems, etc. AIM OF THE STUDY: The present study investigates possible role of hydro-alcoholic extract of C. Read More

Curr Mol Pharmacol 2020 May 12. Epub 2020 May 12.

Post Graduate Institute of Medical Education and Research, Chandigarh. India.

Background: Alcoholic neuropathy is a chronic disorder caused by excessive consumption of alcohol. Damage to the nerves results in unusual sensations in the limbs, decrease mobility and loss of some body functions.

Objective: Alcohol is considered a major villain for exclusively creating the debilitating condition of the neuropathic state. Read More

Neurotoxicology 2020 May 5;79:67-74. Epub 2020 May 5.

Toxicological Information Centre, General University Hospital, Prague, Czech Republic; Department of Occupational Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: Methanol is a widely used industrial short-chain aliphatic alcohol with known neurotoxic properties. Mass poisoning outbreaks due to the consumption of methanol-adulterated alcoholic drinks present a challenge to healthcare providers due to the high mortality and serious central nervous system (CNS) damage in survivors. However, the impact of methanol exposure on the peripheral nervous system is unknown. Read More

Eat Weight Disord 2020 Mar 4. Epub 2020 Mar 4.

Neurology Unit, "A. Manzoni" Hospital-ASST Lecco, Via dell'Eremo 9/11, 23900, Lecco, Italy.

Introduction: Nowadays, reports of beriberi are rare in developed countries. Wernicke encephalopathy may be present in about 25% of patients with beriberi.

Case Report: We report the case of a woman with history of depression and chronic eating disorder, who complained Wernicke encephalopathy and beriberi. Read More

Open Access Maced J Med Sci 2019 Sep 10;7(18):3013-3014. Epub 2019 Sep 10.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Pseudo-ainhum is defined as any case of auto-amputation not associated with the classic spontaneous ainhum seen in Africans with unknown etiology.

Case Presentation: A severely ill 58-year-old male patient presented with a painless constricting circular band on his left second toe. His medical history was remarkable for severe alcoholic liver cirrhosis with ascites formation leading to dyspnea. Read More

Diabetes Metab Syndr Obes 2019 20;12:2405-2410. Epub 2019 Nov 20.

Metabolic Diseases Unit, Department of Clinical and Experimental Medicine, University Magna Graecia, Catanzaro, Italy.

Introduction: Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of complications in type 1 diabetes (T1DM) patients. To date, several biochemical indexes of NAFLD have been developed. Among these, hepatic steatosis index (HSI) strongly relates with the results of magnetic resonance. Read More

Liver Int 2020 Feb 31;40(2):347-354. Epub 2019 Oct 31.

Department of Pathophysiology and Transplantation, Ca' Granda IRCCS Foundation, Policlinico Hospital, University of Milan, Milan, Italy.

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are closely associated, and liver fibrosis has been related to macrovascular complications. We examined whether liver fibrosis, diagnosed by FibroScan , correlates with chronic vascular complications in a cohort of T2DM.

Methods: We recruited 394 outpatients with T2DM attending five Italian diabetes centres who underwent liver ultrasonography (US), FibroScan and extensive evaluation of macrovascular and microvascular diabetic complications. Read More

J Clin Invest 2019 12;129(12):5424-5441

Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.

Excessive alcohol consumption is associated with spontaneous burning pain, hyperalgesia, and allodynia. Although acetaldehyde has been implicated in the painful alcoholic neuropathy, the mechanism by which the ethanol metabolite causes pain symptoms is unknown. Acute ethanol ingestion caused delayed mechanical allodynia in mice. Read More

Turk J Phys Med Rehabil 2019 Mar 21;65(1):87-92. Epub 2018 Dec 21.

Department of Physical Medicine and Rehabilitation, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Peroneal palsy is compression neuropathy of the peroneal nerve, which presents with foot drop. Patients with unilateral peroneal nerve palsy are frequently encountered in clinical practice. Although bilateral peroneal nerve palsy is rare, bilateral foot drop due to peroneal nerve palsy is much less common. Read More

Clin Chem 2019 08;65(8):956-960

Department of Biochemistry and Laboratory Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain.

Lancet Diabetes Endocrinol 2019 09 22;7(9):684-694. Epub 2019 Jul 22.

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany; German Center for Diabetes Research, Munich, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

Background: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications differ among these clusters, during 5-years of follow-up.

Methods: Patients with newly diagnosed type 1 or type 2 diabetes in the German Diabetes Study underwent comprehensive phenotyping and assessment of laboratory variables. Read More

Curr Pharm Des 2019 ;25(18):2051-2059

Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), London, United Kingdom.

Background: Obesity frequently co-exists with type 2 diabetes mellitus (T2DM), leading to the socalled "diabesity epidemic". The metabolic syndrome (MetS), a cluster of central obesity, hypertension, dysglycemia, insulin resistance and/or atherogenic dyslipidemia, as well as non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of MetS, has been associated with increased cardiovascular disease (CVD), T2DM and chronic kidney disease (CKD) incidence. However, the association between obesity, MetS (including NAFLD) and diabetic microvascular complications is less evident. Read More

Rev Med Liege 2019 May;74(5-6):310-313

Service de Neurologie, CHU Liège, Belgique.

Chronic alcohol consumption results in multiple peripheral and central nervous system dysfunctions. Some are due to the direct action of alcohol or its derivatives, others are induced by the vitamin deficiencies associated with alcoholism, others are eventually related to the failure of other vital organs, such as the liver. In this short review, we describe alcohol-induced neuropathy, Gayet-Wernicke syndrome, Korsakoff syndrome, alcoholic dementia, Marchiafava-Bignami syndrome, hepatic encephalopathy, alcoholic epilepsy and manifestations of alcohol withdrawal. Read More

Am J Phys Med Rehabil 2020 03;99(3):e32-e34

From the Department of Physical Medicine & Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Although generally presenting as a chronic, progressive peripheral neuropathy, we present a case of acute alcoholic neuropathy initially mistaken for acute Guillain-Barré syndrome. Electrodiagnostic evaluation of alcoholic neuropathy reveals an axonal neuropathy and may be complicated by demyelination if comorbid nutritional deficiencies are present. This is in contrast to the significant demyelination classically associated with Guillain-Barré syndrome. Read More

Ann Transl Med 2019 Apr;7(Suppl 2):S67

Neurology Department, AP-HP, Lariboisière University Hospital, Paris, France.

The understanding and management of Wilson disease (WD) have dramatically improved since the first description of the disease by K. Wilson more than a century ago. However, the persistent long delay between the first symptoms and diagnosis emphasizes challenges in diagnosing earlier this copper overload disorder. Read More

Prim Care Diabetes 2019 12 1;13(6):505-514. Epub 2019 May 1.

Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Non-alcoholic fatty liver disease (NAFLD) affects risks of type 2 diabetes (T2D), diabetes-related complications, and cardiovascular disease in a complex manner. This study is designed to clarify associations of sonographically-detected NAFLD and serum liver enzymes with diabetes-related microvascular complications.

Methods: A matched case-contorl study was designed for 440 patients with T2D and at least one of the chronic diabetes-related microvascular complications and 495 age- and gender-matched control patients with T2D. Read More

J Clin Exp Hepatol 2019 Mar-Apr;9(2):257-267. Epub 2018 Aug 27.

Division of Gastroenterology and Hepatology, NewYork-Presbyterian Hospital/Weill Cornell Medicine, 1305 York Avenue, 4th Floor, New York, NY, 10065, USA.

Small intestinal bacterial overgrowth (SIBO) is defined by increased density and/or abnormal composition of microbiota in the small bowel. SIBO is often encountered in patients with cirrhosis as a result of impaired intestinal motility and delayed transit time, both of which are exacerbated by more severe liver disease. Additional risk factors for SIBO commonly encountered in cirrhotic patients include coexisting diabetes, autonomic neuropathy, and/or alcoholic use. Read More

Intern Med J 2019 04;49(4):536-539

Neurological Intervention and Imaging Service of WA (NIISwa), Royal Perth Hospital, Perth, Western Australia, Australia.

Wernicke encephalopathy (WE) is a neurological emergency that develops in the setting of thiamine deficiency, and is characterised by symptoms of confusion, ophthalmoplegia and gait ataxia. Less recognised signs and symptoms include vestibular dysfunction, hearing impairment, peripheral neuropathy, and in severe cases, coma. This case study describes a non-alcoholic patient, who presents with significant auditory and vestibular changes in addition to the classic symptoms of WE. Read More

Br J Dermatol 2019 02;180(2):e35

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

J Neurol 2019 Dec 22;266(12):2907-2919. Epub 2018 Nov 22.

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.

The primary aim of this systematic review was to establish the prevalence, character, and risk factors of peripheral neuropathy amongst chronic alcohol abusers and to identify the most appropriate management strategies. In this review, possible pathogenetic mechanisms are also discussed. A systematic, computer-based search was conducted using the PubMed database. Read More

Clin Liver Dis 2019 02;23(1):141-155

Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, 7200 Cambridge Street, 9th Floor, MS:BCM609, Houston, TX 77030, USA. Electronic address:

Chronic alcohol use induces silent changes in the structure and function of the central and peripheral nervous systems that eventually result in irreversible, debilitating repercussions. Once identified, nutritional supplementation and cessation measures are critical in preventing further neurologic damage. The proposed mechanisms of neuronal injury in chronic alcohol abuse include direct toxic effects of alcohol and indirect effects, including those resulting from hepatic dysfunction, nutritional deficiencies, and neuroinflammation. Read More

Am J Case Rep 2018 Oct 26;19:1272-1278. Epub 2018 Oct 26.

Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Rhabdomyolysis is a syndrome characterized by muscle necrosis and secretion of intracellular muscle components into the blood circulation. Acute compartment syndrome is a potential complication of severe rhabdomyolysis. CASE REPORT We report 3 cases of compartment syndrome-related peripheral neuropathy in alcoholic individuals with rhabdomyolysis. Read More

Acta Histochem 2018 Nov 14;120(8):789-796. Epub 2018 Sep 14.

Department of Anatomy, Institute of Biosciences, São Paulo State University, Botucatu, SP, Brazil. Electronic address:

The chronic use of ethanol causes neuropathy and atrophy of type II fibers and promotes vitamin D decrease. This study evaluated cholecalciferol effects on the deep fibular nerve and extensor digitorum longus (EDL) muscle using an UChB ethanol-preferring rats model. Blood analyses were carried out to measure levels of 25-hydroxycholecalciferol (25(OH)D), calcium (Ca), Phosphorus (P), and parathyroid hormone (PTH). Read More

Phytomedicine 2018 Sep 17;48:129-140. Epub 2018 Apr 17.

Cancer Center, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: Pathological pain conditions can be triggered after peripheral nerve injury and/or inflammation. It is a major clinical problem that is poorly treated with available therapeutics. Curcumin is a phenolic compound derived from Curcuma longa, being widely used for its antioxidant, anti-inflammatory and immunomodulatory effects. Read More

Front Immunol 2018 22;9:1107. Epub 2018 May 22.

Department of Neurosciences, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

alcohol exposure is emerging as a major risk factor for lifelong aberrant neuroimmune function. Fetal alcohol spectrum disorder encompasses a range of behavioral and physiological sequelae that may occur throughout life and includes cognitive developmental disabilities as well as disease susceptibility related to aberrant immune and neuroimmune actions. Emerging data from clinical studies and findings from animal models support that of fetal alcohol exposure may reprogram the developing central nervous system leading to altered neuroimmune and neuroglial signaling during adulthood. Read More

J Diabetes Complications 2018 03 29;32(3):321-324. Epub 2017 Dec 29.

Dept of Endocrinology, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales 2050, Australia; Greg Brown Diabetes and Endocrinology Research Laboratory, Charles Perkins Centre and Bosch Institute, Building D17, The University of Sydney, New South Wales 2006, Australia. Electronic address:

Aims: The impact of non-alcoholic fatty liver disease (NAFLD) presence and severity on the diabetes phenotype remains unclear. Our study aimed to explore and contrast the phenotypes associated with higher ALT and high-risk NAFLD fibrosis score (NFS) in type 2 diabetes.

Methods: 324 patients with type 2 diabetes mellitus who were seen at a diabetes centre for a complications assessment with data for NFS were available for study. Read More

J Neuroophthalmol 2018 Jun;38(2):167-171

Department of Ophthalmology (FP, MSS, MBK), Eye Research Center, Tehran University of Medical Sciences, Rassoul Akram Hospital, Tehran, Iran; Department of Ophthalmology (FP), Eye Research Center, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran; Eye Research Center (AN, NP), Farabi Hospital, Tehran University of Medical Sciences; and Department of Internal Medicine (AH), Rassoul Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Methanol poisoning can cause an optic neuropathy that is usually severe and irreversible and often occurs after ingestion of illicit or homemade alcoholic beverages. In this study, we evaluated the potential neuroprotective effect of erythropoietin (EPO) on visual acuity (VA) in patients with methanol optic neuropathy.

Methods: In a prospective, noncomparative interventional case series, consecutive patients with methanol optic neuropathy after alcoholic beverage ingestion were included. Read More

Clin Neurol Neurosurg 2018 01 8;164:1-4. Epub 2017 Nov 8.

Department of Experimental Biomedicine and Clinical Neurosciences (BioNeC), University of Palermo, Italy. Electronic address:

Thiamine (vitamin B1) deficiency is a common condition in alcohol abusers, which can lead to damage of both the peripheral and the central nervous systems. Here we describe the case of an alcoholic patient who presented with acute onset of ataxia, severe weakness of the four limbs, and hypoesthesia and dysesthesia of the distal portion of the upper and lower extremities. The clinical picture also included mental confusion and amnesia. Read More

Clin Mol Hepatol 2018 12 25;24(4):417-423. Epub 2017 Oct 25.

Department of Neurology, Stroke Unit, University Hospital of Nancy, France.

Anemia appears frequently in patients with alcoholic liver disease (ALD) but has never been linked to bilateral nonarteritic anterior ischemic optic neuropathy (NAION). A 65-year-old woman with a medical history of alcoholic cirrhosis was admitted for bilateral NAION. On admission, she was found to have a low arterial pressure and severe normocytic anemia (48 g/L). Read More

BMJ Case Rep 2017 Sep 26;2017. Epub 2017 Sep 26.

Department of Gastroenterology and Internal Medicine, Suwa Central Hospital, Chino, Nagano, Japan.

Copper deficiency is a disease that causes cytopaenia and neuropathy and can be treated by copper supplementation. Long-term tube feeding, long-term total parenteral nutrition, intestinal resection and ingestion of zinc are known copper deficiency risk factors; however, alcohol abuse is not. In this case, a 71-year-old man had difficulty waking. Read More

Cancers (Basel) 2017 Sep 23;9(10). Epub 2017 Sep 23.

In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 1L5, Canada.

Previously called Crow-Fukase syndrome, POEMS syndrome is characterized by poly-neuropathy, osteo-sclerotic myeloma, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Extremely elevated levels of serum vascular endothelial growth factor (VEGF) are characteristic of the syndrome. Chronic hepatitis B (HBV) and C (HCV) infections can also be present in POEMS. Read More

Metab Brain Dis 2017 10 28;32(5):1649-1657. Epub 2017 Jun 28.

Section of Neuromuscular Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuhsing Street, Kueishan, Taoyuan, Taiwan.

In this study, we present the clinical manifestations, brain magnetic resonance imaging (MRI) and concurrent polyneuropathies in two patients with non-alcoholic Wernicke's encephalopathy (WE) after gastrojejunostomy (Billroth II) anastomosis procedures. These patients developed sub-acute onset of disorientation and disturbance of consciousness following several weeks of poor intake. Peripheral neuropathy of varying severity was noted before and after the onset of WE. Read More

Muscle Nerve 2018 Jan 19;57(1):33-39. Epub 2017 Jun 19.

University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, 14642, USA.

Introduction: This study describes clinical, laboratory, and electrodiagnostic features of a severe acute axonal polyneuropathy common to patients with acute nutritional deficiency in the setting of alcoholism, bariatric surgery (BS), or anorexia.

Methods: Retrospective analysis of clinical, electrodiagnostic, and laboratory data of patients with acute axonal neuropathy.

Results: Thirteen patients were identified with a severe, painful, sensory or sensorimotor axonal polyneuropathy that developed over 2-12 weeks with sensory ataxia, areflexia, variable muscle weakness, poor nutritional status, and weight loss, often with prolonged vomiting and normal cerebrospinal fluid protein. Read More

J Fr Ophtalmol 2017 Jun 13;40(6):e235-e239. Epub 2017 May 13.

CHU Brugmann, 4, place Arthur-Van-Gehuchten, 1020 Bruxelles, Belgique.

Indian J Dermatol 2017 Mar-Apr;62(2):184-190

Department of Dermatology, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.

Background: Chronic alcohol intake impacts skin directly, through organ dysfunction or by modifying preexisting dermatoses. However, dermatoses afflicting chronic alcoholics figure in a few studies only.

Aim: This study aims to correlate the spectrum of dermatoses in chronic alcoholics with the quantum/duration of alcohol intake and raised liver transaminases. Read More

J Diabetes Complications 2017 Jun 12;31(6):1021-1026. Epub 2017 Feb 12.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy.

Aims: Presently, data on the association between nonalcoholic fatty liver disease (NAFLD) and distal symmetric polyneuropathy in people with diabetes are scarce and conflicting. The aim of this retrospective, cross-sectional study was to examine whether NAFLD was associated with an increased prevalence of distal symmetric polyneuropathy in type 1 diabetic adults.

Methods: We studied all white type 1 diabetic outpatients (n = 286, 42. Read More

J Pain Res 2017 20;10:219-228. Epub 2017 Jan 20.

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.

Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant regeneration. Common etiologies of neuropathy include chronic illnesses and medication use. Chronic disorders, such as diabetes and alcoholism, can cause neuronal injury and consequently NeuP. Read More

Presse Med 2017 Mar 3;46(2 Pt 1):165-171. Epub 2016 Nov 3.

Centre hospitalier Sainte-Anne, université Paris 5, Descartes, service d'addictologie, 1, rue Cabanis, 75014 Paris, France.

Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated. Read More

J Diabetes Investig 2016 Nov 20;7(6):889-894. Epub 2016 Apr 20.

Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Aims/introduction: Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder of the liver. The relationship between NAFLD and type 2 diabetes remains largely unknown. The aim of the present study was to determine the incidence of complications arising from the interaction between NAFLD and type 2 diabetes. Read More

J Leukoc Biol 2016 11 26;100(5):951-959. Epub 2016 Jul 26.

Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Fetal alcohol spectrum disorder (FASD), which results from ethanol exposure during pregnancy, and alcohol use disorder (AUD), which includes both binge and chronic alcohol abuse, are strikingly common and costly at personal and societal levels. These disorders are associated with significant pathology, including that observed in the CNS. It is now appreciated in both humans and animal models that ethanol can induce inflammation in the CNS. Read More

Neurology 2016 Nov 28;87(21):2220-2229. Epub 2016 Oct 28.

From the Department of Neurology (H.K., S.I., M.T., Y.K., M.I., M.K., G.S.) and Research Division of Dementia and Neurodegenerative Disease (G.S.), Nagoya University Graduate School of Medicine; Department of Neurology (Y.M., Y.A.), Graduate School of Medical Sciences, Kumamoto University; and Department of Medicine (Neurology and Rheumatology) (S.-i.I.), Shinshu University School of Medicine, Matsumoto, Japan.

Objective: To examine the morphology of Schwann cells and endoneurial microvessels with electron microscopy.

Methods: Sural nerve biopsy specimens from 49 patients with familial amyloid polyneuropathy (FAP) with transthyretin Val30Met mutation were assessed. Patients included 11 early-onset cases from endemic foci and 38 late-onset cases from nonendemic areas. Read More

J Dig Dis 2016 Nov;17(11):735-746

Clinica Medica 'A. Murri', Department of Biomedical Sciences and Human Oncology, 'Aldo Moro' University Medical School, Bari, Italy.

Objective: To carry out a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathy in chronic alcoholics before and one year after abstinence.

Methods: Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lactulose H -breath test), stool form score (indirect marker of colonic transit), and autonomic neuropathy (sweat spot test, R-R ratio) were assessed at baseline in 268 subjects (136 chronic alcoholics and 132 healthy controls). A subgroup of 39 patients was re-evaluated after 12 months of abstinence. Read More

J Ethnopharmacol 2016 Dec 23;194:117-130. Epub 2016 Aug 23.

Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran. Electronic address:

Ethnopharmacological Relevance: According to traditional medicine, rosemary (Rosmarinus officinalis) has been used in many ailments such as dysmenorrhea, rheumatic pain and stomachache.

Aim Of The Study: This work was carried out to evaluate putative anti-allodynic and anti-hyperalgesic effects of Rosmarinus officinalis alcoholic extract and some spinal cord molecular changes on a neuropathic pain model in rats.

Materials And Methods: Peripheral neuropathy was induced by chronic constriction injury (CCI) of sciatic nerve. Read More

Curr Treat Options Neurol 2016 Aug;18(8):37

Gastrenterology and Hepatology Service, Hospital de Santa Maria, Lisbon, Portugal.

Opinion Statement: Liver disease, both in its acute and chronic forms, can be associated with a wide spectrum of neurologic manifestations, both central and peripheral, ranging in severity from subclinical changes to neurocritical conditions. Neurologists are frequently consulted to participate in their management. In this review, we present an overview of management strategies for patients with hepatic disease whose clinical course is complicated by neurologic manifestations. Read More

Diabetologia 2016 07 22;59(7):1422-1429. Epub 2016 Apr 22.

Human Development and Health Academic Unit, Faculty of Medicine, The Institute of Developmental Sciences (IDS), MP887, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK.

Aims/hypothesis: The effect of n-3 fatty acid treatment on temperature perception as a sensory nerve function modality is uncertain. In patients with non-alcoholic fatty liver disease (NAFLD) both with and without type 2 diabetes, we: (1) tested whether 15-18 months' treatment with 4 g/day of docosahexaenoic plus eicosapentaenoic acid (DHA+EPA) improved hot (HPT) and cold (CPT) temperature perception thresholds and (2) explored factors associated with HPT and CPT, in a randomised, double-blind, placebo-controlled trial.

Methods: The effect of treatment (n = 44) on HPT, CPT and temperature perception index (TPI: difference between HPT and CPT) was measured at the big toe in 90 individuals without neuropathy (type 2 diabetes; n = 30). Read More

J Med Case Rep 2016 Mar 31;10:72. Epub 2016 Mar 31.

Keck School of Medicine, University of Southern California, Los Angeles County Medical Center, 1520 San Pablo Street Suite 3000, Los Angeles, CA, 90033, USA.

Background: Neuropathy is a rare adverse side effect of disulfiram therapy and is under-recognized. There have been few case reports documenting this side effect.

Case Presentation: Two cases of disulfiram peripheral neuropathy are discussed. Read More

Mymensingh Med J 2016 Jan;25(1):176-8

Dr Abed Hussain Khan, Medical Officer, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.

A 28-year-old man, smoker having history of occasional alcohol intake--was admitted in the Department of Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU) with gradual diminution of vision in both eyes 10 days after consumption of homemade alcoholic beverage in a wedding ceremony. His initial acuity of vision was limited to no perception of light in right eye and hand movement in left eye. Fundus examination revealed pale optic discs in both eyes. Read More