8,727 results match your criteria Alcoholic Hepatitis


Increased Risk of Death in First Year After Liver Transplantation Among Patients with Nonalcoholic Steatohepatitis vs Liver Disease of Other Etiologies.

Clin Gastroenterol Hepatol 2019 Apr 17. Epub 2019 Apr 17.

Gastroenterology, Henry Ford Hospital, Detroit, Michigan, United States.

Background & Aims: An increasing number of patients with non-alcoholic steatohepatitis (NASH) require liver transplantation. We compared outcomes of patients with liver diseases of different etiologies (NASH, hepatitis C virus [HCV]-associated liver disease, and alcohol-associated liver disease [ALD]).

Methods: We analyzed data from the United Network for Organ Sharing registry on 6344 patients who underwent liver transplantation for NASH, 17,037 for cirrhosis from chronic HCV infection, and 9279 for ALD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193042
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http://dx.doi.org/10.1016/j.cgh.2019.04.033DOI Listing
April 2019
1 Read

Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio.

Clin Mol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Cancer Center, University of Hawaii, Honolulu, HI, USA.

Background/aims: Inflammation-based scores, such as the neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis in hepatocellular carcinoma (HCC); but variable cut-off values and potential lack of specificity have limited the utility of NLR. This study evaluates NLR in a large cohort of HCC patients.

Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. Read More

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http://dx.doi.org/10.3350/cmh.2019.0004DOI Listing
April 2019
2 Reads

Inter- and intra-reader agreement for gadoxetic acid-enhanced MRI parameter readings in patients with chronic liver diseases.

Eur Radiol 2019 Apr 18. Epub 2019 Apr 18.

Department of Biomedical Imaging and Imaging-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objectives: To examine inter- and intra-observer agreement for four simple hepatobiliary phase (HBP)-based scores on gadoxetic acid (GA)-enhanced MRI and their correlation with liver function in patients with mixed chronic liver disease (CLD).

Methods: This single-center, retrospective study included 287 patients (62% male, 38% female, mean age 53.5 ± 13. Read More

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http://dx.doi.org/10.1007/s00330-019-06182-zDOI Listing

Early liver transplantation for severe alcoholic hepatitis.

Clin Liver Dis (Hoboken) 2018 Mar 6;11(3):69-72. Epub 2018 Apr 6.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai Recanati/Miller Transplantation Institute New York NY.

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http://dx.doi.org/10.1002/cld.693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385942PMC
March 2018
1 Read

[Protective effect of Yindan Pinggan Capsules on liver inflammatory injury and oxidative stress induced by acute alcoholic intake].

Authors:
Juan Yu

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1233-1237

Zhangzhou Pien Zai Huang Parmaceutical Co.,Ltd. Zhangzhou 363000,China.

To investigate the protective effect of Yindan Pinggan Capsules(YDPG)on acute alcoholic liver inflammatory injury and oxidative stress,sixty male Sprague-Dawley rats were divided into 6 groups randomly:normal group,model group,YDPG-L group,YD-PG-M group,YDPG-H group and Haiwang Jinzun(HWJZ)group.Except for the normal rats,while the remaining rats were administered orally with alcohol(50%,5 g·kg~(-1)).One hour after drinking,the rats in normal or model group were administered orally with PS,while the remaining rats were separately given YDPG(0. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20190107.002DOI Listing
March 2019
1 Read

Steroids for Severe Alcoholic Hepatitis: More Risk Than Reward?

Clin Liver Dis (Hoboken) 2018 Dec 2;12(6):151-153. Epub 2019 Jan 2.

MedStar Georgetown Transplant Institute, Georgetown University Hospital Washington DC.

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http://dx.doi.org/10.1002/cld.736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446448PMC
December 2018
1 Read

Hepatocellular carcinoma surveillance: An evidence-based approach.

World J Gastroenterol 2019 Apr;25(13):1550-1559

Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, United States.

Hepatocellular carcinoma (HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i13/1550.htm
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http://dx.doi.org/10.3748/wjg.v25.i13.1550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452232PMC
April 2019
4 Reads

De Novo Hepatitis B Virus Infection After Liver Transplantation in Hepatitis B Core-positive Recipients Using Hepatitis B Core-negative Grafts.

Transplant Proc 2019 Apr 7;51(3):842-844. Epub 2019 Jan 7.

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Background: Hepatitis B core antibody-positive (HBcAb+) graft is known as a risk for de novo hepatitis B virus (HBV) infection in recipients after liver transplantation (LT). However, little is known about the possibility or incidence of de novo HBV infections after LT in hepatitis B surface antigen-negative (HBsAg-)/HBcAb+ recipients using HBsAg-/HBcAb- grafts. The study aimed to evaluate the prevalence of de novo HBV infection in HBsAg-/HBcAb+ recipients using HBsAg-/HBcAb- grafts. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.025DOI Listing
April 2019
1 Read

The Epidemiology of Hepatocellular Carcinoma in the USA.

Curr Gastroenterol Rep 2019 Apr 11;21(4):17. Epub 2019 Apr 11.

Section of Gastroenterology and Hepatology, Baylor College of Medicine, 7200 Cambridge Street, Houston, TX, 77030, USA.

Purpose Of Review: To discuss current knowledge and recent findings regarding the epidemiology of hepatocellular carcinoma (HCC) in the USA.

Recent Finding: The US incidence rate of HCC is increasing, although the pace may have somewhat slowed since 2010. In 2012, incidence rates of HCC in Hispanics surpassed those of Asians. Read More

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http://dx.doi.org/10.1007/s11894-019-0681-xDOI Listing
April 2019
1 Read

Liver-related mortality in the United States: hepatitis C declines, non-alcoholic fatty liver and alcohol rise.

Transl Gastroenterol Hepatol 2019 22;4:19. Epub 2019 Mar 22.

Department of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.21037/tgh.2019.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458348PMC
March 2019
1 Read

Early and late mortality following unscheduled admissions for severe liver disease across England and Wales.

Aliment Pharmacol Ther 2019 Apr 11. Epub 2019 Apr 11.

Medical School, Swansea University, Swansea, UK.

Background: There is a known shortfall in hepatology service resources across England and Wales.

Aim: To investigate early and late mortality following unscheduled admissions for severe liver disease, overall and by cause of death, and to determine how mortality is related to admissions to transplant centres, transplant surgery, hospital size, consultant specialty, patient socio-demographics, seasonal and geographical factors.

Methods: Cohorts of people with a first unscheduled admission for severe liver disease across England and Wales from 2004, based on record linkage of national inpatient and mortality data. Read More

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http://doi.wiley.com/10.1111/apt.15232
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http://dx.doi.org/10.1111/apt.15232DOI Listing
April 2019
4 Reads

Glucocorticosteroids for people with alcoholic hepatitis.

Cochrane Database Syst Rev 2019 Apr 9;4:CD001511. Epub 2019 Apr 9.

Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark, DK-2100.

Background: Alcoholic hepatitis is a form of alcoholic liver disease characterised by steatosis, necroinflammation, fibrosis, and complications to the liver. Typically, alcoholic hepatitis presents in people between 40 and 50 years of age. Alcoholic hepatitis can be resolved if people abstain from drinking, but the risk of death will depend on the severity of the liver damage and abstinence from alcohol. Read More

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http://dx.doi.org/10.1002/14651858.CD001511.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455893PMC
April 2019
1 Read

Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long-term follow-up study of 1317 patients.

Aliment Pharmacol Ther 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.

Aim: We compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based cohort of patients with incident cirrhosis.

Material And Methods: We used population-based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Read More

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http://doi.wiley.com/10.1111/apt.15255
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http://dx.doi.org/10.1111/apt.15255DOI Listing
April 2019
8 Reads

Association Between Alcoholic Cirrhosis and Hemorrhagic Stroke: A Nationwide Population-based Study.

Alcohol Alcohol 2019 Apr 8. Epub 2019 Apr 8.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taiwan.

Aims: This study investigated whether patients with alcoholic cirrhosis have a high risk of hemorrhagic stroke.

Methods: In this study, 17,094 patients diagnosed with cirrhosis between 2000 and 2010 were identified using the Taiwan National Health Insurance claims data. Identified patients were randomly selected and propensity score matched with individuals without cirrhosis according to age, sex, comorbidities and index year. Read More

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http://dx.doi.org/10.1093/alcalc/agz025DOI Listing
April 2019
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Influence of Sorafenib on Host Immunity in Patients with Liver Cirrhosis With Advanced Hepatocellular Carcinoma Stratified by Etiology.

Anticancer Res 2019 Apr;39(4):2183-2191

Division of Gastroenterology and Hepatology, Department of Internal Medicine (Omori), School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.

Aim: We previously reported that sorafenib induces Th1 [interferon-γ (IFNγ)-positive interleukin 4 (IL4)-negative] dominance which prevents tumor cells from escaping the host immune system in patients with liver cirrhosis (LC) and advanced hepatocellular carcinoma (aHCC). However, in that study we did not assess the influence of sorafenib on host immunity according to the etiology of LC. Therefore, this study was retrospectively performed to evaluate the impact of sorafenib therapy for aHCC on host immunity in patients stratified according to the etiology of LC: Patients and Methods: A total of 116 adult Japanese patients with LC and aHCC received sorafenib therapy at our hospital. Read More

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http://dx.doi.org/10.21873/anticanres.13333DOI Listing
April 2019
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4-Methylcoumarin-[5,6-g]-hesperetin attenuates inflammatory responses in alcoholic hepatitis through PPAR-γ activation.

Toxicology 2019 Apr 3;421:9-21. Epub 2019 Apr 3.

The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Anhui Province, China; The Key Laboratory of Anti-Inflammatory of Immune Medicines, Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University, China. Electronic address:

4-Methylcoumarin-[5,6-g]-hesperetin (4-MCH) is a hesperidin derivative produced by the structural modification of hesperetin. Alcoholic hepatitis (AH) is the origin of many serious liver diseases that are accompanied by hepatic inflammation. In this study, we detected the anti-inflammatory activity of 4-MCH in EtOH fed mice and examined the potential molecular mechanism of this activity. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.004DOI Listing
April 2019
2 Reads
3.621 Impact Factor

Incidence and Risk Factors Associated With 30-Day Readmission for Alcoholic Hepatitis.

J Clin Gastroenterol 2019 Apr 3. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester.

Background: Alcohol abuse and liver disease are associated with high rates of 30-day hospital readmission, but factors linking alcoholic hepatitis (AH) to readmission are not well understood. We aimed to determine the incidence rate of 30-day readmission for patients with AH and to evaluate potential predictors of readmission.

Methods: We used the Nationwide Readmissions Database to determine the 30-day readmission rate for recurrent AH between 2010 and 2014 and examined trends in readmissions during the study period. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001202DOI Listing
April 2019
2 Reads
3.498 Impact Factor

[Alcoholic liver disease: the roles of genetic-epigenetic factors and the effect of abstinence].

Orv Hetil 2019 Apr;160(14):524-532

Klinikai Központ, I. Belgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, Ifjúság u. 13., 7624.

The pathogenesis of alcoholic liver disease depends not only on the toxic effects of alcohol, but also on the complex interaction of host's and environmental factors. Thus, the genetic pre-disposition, co-morbidities and behavioral factors all play a role in the individual variations in the disease outcomes. On the other hand, the essential part of the therapeutic strategy is the complete withdrawal of the harmful etiological agent. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31352
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http://dx.doi.org/10.1556/650.2019.31352DOI Listing
April 2019
8 Reads

[Research progress of single-nucleotide polymorphism in theTM6SF2 rs58542926].

Zhonghua Gan Zang Bing Za Zhi 2019 Mar;27(3):223-226

Department of Gastroenterology II, Qingdao Municipal Hospital, Qingdao 266000, China.

Transmembrane 6 superfamily member 2 (TM6SF2) is a recently discovered gene, which is located on the chromosome 19 (19p12) and encodes a protein consisting of 351 amino acids. Presently, many studies have reported that the single-nucleotide polymorphism of TM6SF2 rs58542926 and plasma lipids are closely related to the incidence and development of diseases, such as non-alcoholic fatty liver disease (NAFLD), cardiovascular disease (CVD), liver cancer, and hepatitis C. This review will summarize the research progress conducted in these areas. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2019.03.012DOI Listing
March 2019
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Factors influencing serum chemerin and kallistatin concentrations in patients with alcohol-induced liver cirrhosis.

Ann Agric Environ Med 2019 Mar 3;26(1):143-147. Epub 2019 Jan 3.

Department of Nephrology, Medical University, Lublin, Poland.

Introduction: In Poland, an increasing number of patients are hospitalized due to liver diseases. One of the common liver diseases is cirrhosis, which can be caused by alcohol, viral hepatitis, autoimmune processes and metabolic diseases.

Material And Methods: The study included 99 patients with alcoholic cirrhosis from the Lublin region of Eastern Poland. Read More

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http://dx.doi.org/10.26444/aaem/100536DOI Listing

Cardiac health in patients with hepatitis B virus-related cirrhosis.

Medicine (Baltimore) 2019 Mar;98(13):e14961

Department of Liver Intensive Care Unit.

Not only alcoholic cirrhosis related to cardiac dysfunction, cirrhosis caused by nonalcoholic etiology including hepatitis B virus (HBV) infection also related to impaired cardiac health. The aims of present study were to perform a noninvasive evaluation of cardiac function and to evaluate exercise performance in HBV related cirrhotic patients without typical symptoms of cardiac disease.Seventy-nine HBV related cirrhotic patients and 103 matched subjects without a previous history of cardiac involvement were recruited. Read More

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http://dx.doi.org/10.1097/MD.0000000000014961DOI Listing
March 2019
2 Reads

The High-Risk Alcoholism Relapse Score Predicts Alcohol Relapse Among Liver Transplant Candidates with Less Than Six Months of Abstinence.

Liver Transpl 2019 Mar 28. Epub 2019 Mar 28.

Liver Transplant Unit, IDIBAPS, CIBERehd, Hospital Clínic, University of Barcelona, Barcelona, Spain.

Background & Aims: The selection of liver transplant (LT) candidates with alcohol use disorder is influenced by the risk of alcohol relapse (AR) after LT. We aimed to investigate the risk factors of AR after LT and its impact on graft and recipient outcomes.

Methods: Retrospective study including all consecutive patients with alcohol use disorder undergoing LT from January 2004 to April 2016 (n=309), excluding alcoholic hepatitis. Read More

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http://dx.doi.org/10.1002/lt.25460DOI Listing
March 2019
1 Read

Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long-term nucleoside analogue.

Liver Int 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Background & Aims: It is unknown how concomitant hepatic steatosis affects disease progression in chronic hepatitis B (CHB). Adipokines such as fibroblast growth factor 21 (FGF21) and adipocyte fatty acid-binding protein (AFABP) have been associated with non-alcoholic fatty liver disease. We determined the significance of these metabolic markers in CHB-related liver injury. Read More

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http://dx.doi.org/10.1111/liv.14104DOI Listing
March 2019
1 Read

Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.

Semin Liver Dis 2019 Mar 25. Epub 2019 Mar 25.

Centre for Liver Research, Institute of Immunology and Immunotherapy, Medical School, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent advances have been made in the treatment of liver disease including the development of highly effective antiviral therapy for hepatitis C and the potential of immunotherapy for HCC. Read More

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http://dx.doi.org/10.1055/s-0039-1678727DOI Listing
March 2019
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Improving survival in patients with hepatocellular carcinoma related to chronic hepatitis C and B but not in those related to non-alcoholic steatohepatitis or alcoholic liver disease: a 20-year experience from a national programme.

Intern Med J 2019 Mar 25. Epub 2019 Mar 25.

New Zealand Liver Transplant unit (NZLTU), Auckland City Hospital, Auckland, New Zealand.

Background: Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer mortality in New Zealand due to endemic Hepatitis B (HBV) infection and recent Hepatitis C (HCV) and obesity epidemics.

Methods: All newly diagnosed cases of HCC referred to NZLTU between 1998 and 2017 were included. Data on patient demographics, liver disease aetiology, screening status and treatment modalities were collected. Read More

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http://dx.doi.org/10.1111/imj.14304DOI Listing
March 2019
1 Read

A HSD17B13 variant protects from hepatocellular carcinoma development in alcoholic liver disease.

Hepatology 2019 Mar 25. Epub 2019 Mar 25.

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Functional Genomics of Solid Tumors laboratory, F-75006, Paris, France.

Introduction: Recently, a loss of function variant (rs72613567) in 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) has been identified as protective of non-alcoholic and alcoholic liver disease (ALD). However, the role of this SNP in the development of HCC is currently unknown.

Materials And Methods: 3,315 European patients with HCC (n=1,109) or without HCC but with chronic liver disease (CLD, n=2,206) from 4 centers were analyzed either by whole-exome sequencing (exploratory cohort, 285 HCC) or genotyped for HSD17B13 rs72613567 (validation cohort, 824 HCC and all CLD). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hep.30623
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http://dx.doi.org/10.1002/hep.30623DOI Listing
March 2019
9 Reads
11.055 Impact Factor

A Lille Model for Predicting the Response of Severe Alcoholic Hepatitis to Corticosteroid Treatment in Japanese Patients.

Hepatol Res 2019 Mar 22. Epub 2019 Mar 22.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, 020-8505, Japan.

Aim: Corticosteroids are the most widely used agents for the treatment of severe alcoholic hepatitis (SAH). The therapeutic effectiveness of corticosteroids is assessed by the Lille model, which has been validated well in Western countries; however, its usefulness has not yet been confirmed independently in Japanese patients. The present study aimed to determine whether the Lille model could predict the prognosis of SAH in Japanese patients. Read More

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http://dx.doi.org/10.1111/hepr.13334DOI Listing
March 2019
1 Read

Prevalence of diabetes in liver cirrhosis: A systematic review and meta-analysis.

Diabetes Metab Res Rev 2019 Mar 22:e3157. Epub 2019 Mar 22.

Department of Surgery, University of Auckland, Auckland, New Zealand.

An association between diabetes mellitus (DM) and liver cirrhosis is well known but estimates of the prevalence of DM in patients with liver cirrhosis vary widely. A systematic review was undertaken to determine the prevalence of DM in adult patients with liver cirrhosis. The Medline, EMBASE and Cochrane Library databases were searched for peer-reviewed studies published in English (1979-2017) that investigated the prevalence of diabetes in adult patients with cirrhosis. Read More

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http://dx.doi.org/10.1002/dmrr.3157DOI Listing
March 2019
1 Read

Biomarkers of macrophage activation and immune danger signals predict clinical outcomes in alcoholic hepatitis.

Hepatology 2019 Mar 19. Epub 2019 Mar 19.

Department of Medicine, University of Massachusetts Medical School, Worcester, MA.

Although mortality due to acute alcoholic hepatitis (AH) correlates with Model for End-Stage Liver Disease (MELD) scores, new biomarkers are critically needed to manage this disease. An increase in inflammatory markers and macrophage activation are associated with acute AH and could be potential biomarkers of clinical events and/or mortality. We enrolled 89 clinically-diagnosed AH patients in four US academic medical centers. Read More

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http://dx.doi.org/10.1002/hep.30617DOI Listing
March 2019
1 Read

Brown fat activation mitigates alcohol-induced liver steatosis and injury in mice.

J Clin Invest 2019 Mar 19;130. Epub 2019 Mar 19.

Chronic alcohol consumption causes liver injury, inflammation and fibrosis, thereby increasing morbidity and mortality. Paradoxically, modest drinking is believed to confer metabolic improvement, but the underlying mechanism remains elusive. Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis. Read More

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http://www.jci.org/articles/view/124376
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http://dx.doi.org/10.1172/JCI124376DOI Listing
March 2019
9 Reads

Reduction in acute kidney injury stage predicts survival in patients with type-1 hepatorenal syndrome.

Nephrol Dial Transplant 2019 Mar 18. Epub 2019 Mar 18.

Scientific Affairs, Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA.

Background: Hepatorenal syndrome type 1 (HRS-1), a form of acute kidney injury (AKI) in cirrhosis, has a median survival of days to weeks if untreated. The impact of reduction in AKI stage on overall survival in cirrhosis, independent of HRS reversal, is unclear.

Methods: The Randomized, placEbo-controlled, double-blind study to confirm the reVERSal of HRS-1 with terlipressin study assessed terlipressin versus placebo, both with albumin, as treatment for HRS-1 for ≤14 days. Read More

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http://dx.doi.org/10.1093/ndt/gfz048DOI Listing
March 2019
4 Reads

Bile ductular reactions in the liver: similarities are only skin deep.

J Pathol 2019 Mar 18. Epub 2019 Mar 18.

Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Extensive bile ductular reactions (DRs) accompany many cholestatic liver diseases such as primary biliary cholangitis and primary sclerosing cholangitis (PSC) as well as parenchymal liver cell diseases such as alcoholic liver disease, non-alcoholic steatohepatitis and HCV and HBV infections. DRs originate from bile ducts or hepatocytes after damage and can be identified by expression of markers associated with cholangiocytes, often being associated with disease progression and fibrosis. In a recent issue of The Journal of Pathology, Govaere et al employed high-throughput RNA sequencing to compare the transcriptomic profiles of DR cells from liver diseases of different aetiology; HCV infection affecting hepatocytes and PSC initially affecting biliary epithelial cells. Read More

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http://dx.doi.org/10.1002/path.5265DOI Listing
March 2019
2 Reads

Underestimation of Liver Transplantation for Alcoholic Hepatitis in the National Transplant Database.

Liver Transpl 2019 May 29;25(5):706-711. Epub 2019 Mar 29.

Department of Gastroenterology, Keck School of Medicine of University of Southern California, Los Angeles, CA.

Alcohol-associated liver disease (ALD) can be coded in United Network for Organ Sharing (UNOS) as either alcoholic cirrhosis or alcoholic hepatitis (AH), without having specific criteria to assign either diagnosis. In this multicenter American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH) study, we sought to assess the concordance of the clinician diagnosis of AH at liver transplantation (LT) listing versus UNOS data entry of AH as listing diagnosis. In a prior study, consecutive early LT recipients transplanted for AH between 2012 and 2017 were identified by chart review at 10 ACCELERATE-AH sites. Read More

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http://dx.doi.org/10.1002/lt.25448DOI Listing
May 2019
2 Reads

Intrahepatic diffuse periportal enhancement patterns on hepatobiliary phase gadoxetate disodium-enhanced liver MR images: Do they correspond to periportal hyperintense patterns on T2-weighted images?

Medicine (Baltimore) 2019 Mar;98(11):e14784

Institute for Clinical Radiology, Ludwig Maximilians-University Hospital Munich, Munich, Germany.

The purpose of this study was to investigate the findings of diffuse periportal enhancement in the liver on hepatobiliary phase gadoxetate disodium-enhanced magnetic resonance images by comparing with the finding of periportal hyperintensity on T2-weighted images and to reveal their clinical significance.Nineteen consecutive patients with diffuse periportal enhancement on hepatobiliary phase images constituted the study population. The intrahepatic diffuse periportal enhancement finding was assessed on whether it corresponded to periportal hyperintense patterns on T2-weighted images or not in the location, and the cases were classified into 2 groups according to this characteristic. Read More

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http://dx.doi.org/10.1097/MD.0000000000014784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426476PMC
March 2019
1 Read

The Changing Face of Liver Transplantation in the United States: The Effect of HCV Antiviral Eras on Transplantation Trends and Outcomes.

Transplant Direct 2019 Mar 20;5(3):e427. Epub 2019 Feb 20.

Division of Hepatobiliary Surgery and Liver Transplantation, Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN.

Background: Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in the United States, although nonalcoholic steatohepatitis (NASH) is on the rise. Increasingly effective HCV antivirals are available, but their association with diagnosis-specific liver transplantation rates and early graft survival is not known.

Methods: The Scientific Registry of Transplant Recipients database records were retrospectively stratified by HCV antiviral era: interferon (2003-2010), protease inhibitors (2011-2013), and direct-acting antivirals (2014 to present). Read More

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http://dx.doi.org/10.1097/TXD.0000000000000866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411219PMC
March 2019
1 Read

and Gene Variants in Liver Fibrosis and Cirrhosis.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.

Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the and genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between variant and variant and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the risk variant for the development of hepatic fibrosis and liver cirrhosis. Read More

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http://dx.doi.org/10.3390/ijms20061277DOI Listing
March 2019
1 Read

Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective.

J Hepatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Health Sciences, National Natural Science Foundation of China, Beijing, China. Electronic address:

Liver diseases affect millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and therapies. Expanded programs for systematic immunization against hepatitis B virus (HBV) have also significantly brought down the number of new cases in many countries, including China. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.03.004DOI Listing
March 2019
3 Reads
11.336 Impact Factor

[When to transplant a patient with alcoholic liver disease?]

Rev Prat 2018 Sep;68(7):761-765

Maladies de l'appareil digestif, hôpital Claude- Huriez, CHRU de Lille, Lille, France.

When to transplant a patient with alcoholic liver disease? Alcoholic liver disease is the leading cause of cirrhosis in France, but there is only a minority of patients who have access to liver transplantation. Although still controversial, this disease is a validated indication of liver transplantation with survival similar to that of other indications. The survival benefit of transplantation is limited to patients with severe decompensation. Read More

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September 2018
2 Reads

[Alcoholic hepatitis].

Rev Prat 2018 Dec;68(10):1113-1118

Service des maladies de l'appareil digestif, hôpital Claude- Huriez, université Lille-2, Inserm U795, Lille, France.

Alcoholic hepatitis. In a context of chronic alcoholic intoxication, the diagnosis of alcoholic hepatitis (AH) relies on a histological definition. When it is symptomatic, AH is a clinical syndrome associating jaundice, moderate fever, sensitivity of the right upper quadrant, loss of appetite and signs of hepatocellular insufficiency in severe forms. Read More

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December 2018
3 Reads

NASH Is the Most Rapidly Growing Etiology for Acute-on-Chronic Liver Failure-Related Hospitalization and Disease Burden in the United States: A Population-Based Study.

Liver Transpl 2019 May;25(5):695-705

University of South Dakota Sanford School of Medicine and Avera Transplant Institute, Sioux Falls, SD.

Acute-on-chronic liver failure (ACLF) is characterized by multiple organ failure (OF) with high short-term mortality. There is lack of population-based data on trends on etiology specific ACLF related burden. National Inpatient Sample (2006-2014) was queried using ICD-09 codes for admissions with cirrhosis and ACLF (≥2 extrahepatic OF). Read More

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http://dx.doi.org/10.1002/lt.25443DOI Listing
May 2019
2 Reads

Utility of the EncephalApp Stroop Test for covert hepatic encephalopathy screening in Chinese cirrhotic patients.

J Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Department of Gastroenterology, Peking University People's Hospital, Beijing, China.

Background And Aim: Considering the large size of the potential population and limitations of common detection methods, covert hepatic encephalopathy (CHE) is difficult to screen for routinely. The present study aims to explore EncephalApp Stroop Test as a smartphone-based CHE screening tool in China.

Methods: A multicenter, single-visit study was carried out. Read More

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http://dx.doi.org/10.1111/jgh.14656DOI Listing
March 2019
3 Reads

Severe takotsubo cardiomyopathy following orthotopic liver transplantation: A case series.

Clin Res Hepatol Gastroenterol 2019 Mar 7. Epub 2019 Mar 7.

Attending Physician, Interventional Cardiology, Department of Cardiology, Banner University Medical Center-Phoenix, Arizona 85006, USA. Electronic address:

Introduction: Acute decompensated heart failure is a known complication following orthotopic liver transplant. Among those, there are some cases of takostubo type cardiomyopathy (TC), commonly referred to as "broken heart syndrome". While the exact mechanism of TC is unknown, it frequently proceeds a physical or emotional stressor. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.11.009DOI Listing
March 2019
1 Read

Role of the intestinal microbiome in liver fibrosis development and new treatment strategies.

Transl Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California. Electronic address:

Liver cirrhosis is a major cause of morbidity and mortality worldwide. The most common chronic liver diseases in western countries are alcohol-associated liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Although these diseases have different causes, liver fibrosis develops via shared mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19315244193003
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http://dx.doi.org/10.1016/j.trsl.2019.02.005DOI Listing
February 2019
5 Reads

Rapid Analysis of Effects of Environmental Toxicants on Tumorigenesis and Inflammation Using a Transgenic Zebrafish Model for Liver Cancer.

Mar Biotechnol (NY) 2019 Mar 9. Epub 2019 Mar 9.

Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore.

Liver cancer remains to be a major health concern in the world today. Several major risk factors such as hepatitis viral infection and non-alcoholic steatohepatitis have been well established for causing liver cancer, but the contribution of environmental pollutants to liver inflammation and carcinogenesis remains poorly studied. Here, we aimed at the development of a rapid assay to test selected environmental toxicants for their potential roles in induction of inflammation and stimulation of liver tumorigenesis. Read More

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http://dx.doi.org/10.1007/s10126-019-09889-8DOI Listing
March 2019
2 Reads

Disease Burden of Hepatocellular Carcinoma: A Global Perspective.

Dig Dis Sci 2019 Apr;64(4):910-917

Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA, USA.

Liver cancer is one of the leading causes of cancer-related mortality around the world. Hepatocellular carcinoma (HCC) is the primary cancer of the liver, accounting for the majority of liver cancers. The risk factors associated with HCC include chronic infections with HBV and HCV, alcoholic liver disease, and nonalcoholic fatty liver disease. Read More

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http://dx.doi.org/10.1007/s10620-019-05537-2DOI Listing
April 2019
2 Reads

Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients.

Biomed Res Int 2019 31;2019:7604939. Epub 2019 Jan 31.

Department of Life Sciences, Universidade do Estado da Bahia, Rua Silveira Martins 2555, Cabula 41150-000, Salvador, Bahia, Brazil.

Background: In inflammatory bowel disease (IBD) patients there are reports of the occurrence of hepatobiliary manifestations, so the aim of this study was to evaluate the hepatobiliary manifestations in patients with Crohn's disease (CD) and ulcerative colitis (UC) from an IBD reference center.

Methods: Cross-sectional study in an IBD reference center, with interviews and review of medical charts, between July 2015 and August 2016. A questionnaire addressing epidemiological and clinical characteristics was used. Read More

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https://www.hindawi.com/journals/bmri/2019/7604939/
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http://dx.doi.org/10.1155/2019/7604939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374878PMC
January 2019
9 Reads

Alcohol abuse and disorder of granulopoiesis.

Pharmacol Ther 2019 Mar 1. Epub 2019 Mar 1.

Department of Integrative Medical Sciences, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, United States of America; Department of Surgery, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, United States of America. Electronic address:

Granulocytes are the major type of phagocytes constituting the front line of innate immune defense against bacterial infection. In adults, granulocytes are derived from hematopoietic stem cells in the bone marrow. Alcohol is the most frequently abused substance in human society. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.03.001DOI Listing
March 2019
2 Reads

The relevance of pyroptosis in the pathogenesis of liver diseases.

Life Sci 2019 Apr 1;223:69-73. Epub 2019 Mar 1.

The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University. Hangzhou, 310000, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310000, China. Electronic address:

Pyroptosis is a novel programmed cell death form which is distinct from other types of cell death. As an inherently inflammatory process, it plays a vital role in cellular lysis and release of pro-inflammatory cytokines when hosts defend against infections. Recent studies have reported that pyroptosis was involved in liver diseases and had important functions in the progress and development of liver diseases. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.060DOI Listing
April 2019
4 Reads

Hepatocellular carcinoma surveillance in the 21st century: Saving lives or causing harm?

Clin Mol Hepatol 2019 Mar 4. Epub 2019 Mar 4.

Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.

Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death worldwide. Prognosis and treatment options largely depend on tumor stage at diagnosis, with curative treatments only available if detected at an early stage. However, two thirds of patients with HCC are diagnosed at a late stage and not eligible for cure. Read More

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http://dx.doi.org/10.3350/cmh.2019.1001DOI Listing
March 2019
1 Read

Molecular Pathogenesis of Cholangiocarcinoma.

BMC Cancer 2019 Feb 28;19(1):185. Epub 2019 Feb 28.

UCL Institute for Liver and Digestive Health, University College London (Royal Free Hospital Campus), Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

Background: Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development. Read More

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http://dx.doi.org/10.1186/s12885-019-5391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394015PMC
February 2019
5 Reads