9,893 results match your criteria Alcoholic Hepatitis


Endothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis.

Hepatol Int 2021 May 5. Epub 2021 May 5.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/ Rosselló, 149-153, 08036, Barcelona, Spain.

Objectives: Alcoholic hepatitis (AH) is a severe condition characterized by a marked inflammatory response and high short-term mortality. Endothelial dysfunction (ED) is an early event in vascular and inflammatory disorders. The aim of this study is to evaluate ED in AH patients. Read More

View Article and Full-Text PDF

A 55-Year-Old Male Presenting With a Lower Extremity Rash: A Case of Immunoglobulin A (IgA) Nephropathy.

Cureus 2021 Mar 29;13(3):e14165. Epub 2021 Mar 29.

Internal Medicine, Henry Ford Health System, Detroit, USA.

Immunoglobulin A (IgA) nephropathy, mesangial deposition of IgA in renal parenchyma, typically presents with hematuria and proteinuria. Leukocytoclastic vasculitis (LCV), a small-vessel vasculitis, can present secondary to IgA. We will discuss a case of secondary IgA nephropathy with concomitant LCV in a patient with reactivated hepatitis C. Read More

View Article and Full-Text PDF

Impact of donor age on liver transplant outcomes in patients with hepatocellular carcinoma: analysis of the SRTR database.

BMC Gastroenterol 2021 Apr 30;21(1):195. Epub 2021 Apr 30.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.

Background: Donor age is an important predictor for liver transplant recipients. Studies have not fully explored its impact on transplant outcomes in hepatocellular carcinoma (HCC) patients as well as its involvement in tumor recurrence.

Methods: HCC patients who received liver transplants during 2010-2017 from the Scientific Registry of Transplant Recipients database were included. Read More

View Article and Full-Text PDF

Changes in liver-related mortality by etiology and sequelae: underlying versus multiple causes of death.

Popul Health Metr 2021 04 29;19(1):22. Epub 2021 Apr 29.

Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: The expanded definition of liver-related deaths includes a wide range of etiologies and sequelae. We compared the changes in liver-related mortality by etiology and sequelae for different age groups between 2008 and 2018 in the USA using both underlying and multiple cause of death (UCOD and MCOD) data.

Methods: We extracted mortality data from the CDC WONDER. Read More

View Article and Full-Text PDF

Multiple Roles of Black Raspberry Anthocyanins Protecting against Alcoholic Liver Disease.

Molecules 2021 Apr 16;26(8). Epub 2021 Apr 16.

School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.

This study aimed to investigate the protective effect of black raspberry anthocyanins (BRAs) against acute and subacute alcoholic liver disease (ALD). Network analysis and docking study were carried out to understand the potential mechanism. Thereafter, the serum biochemical parameters and liver indexes were measured, the histopathological changes of the liver were analyzed in vivo. Read More

View Article and Full-Text PDF

Multiple hepatic inflammatory pseudotumors with elevated alpha-fetoprotein and alpha-fetoprotein lectin 3 fraction with various PET accumulations: a case report.

Surg Case Rep 2021 Apr 28;7(1):107. Epub 2021 Apr 28.

Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Hepatic inflammatory pseudotumor (IPT) is a rare, benign, tumor-like lesion. Because there are no characteristic laboratory markers or radiological features, hepatic IPT is often misdiagnosed as a malignant neoplasm such as hepatocellular carcinoma (HCC).

Case Presentation: A 68-year-old man with liver dysfunction due to chronic hepatitis C virus infection and alcoholic liver disease presented with hepatic tumors in segments III and VIII. Read More

View Article and Full-Text PDF

The PDE5 inhibitor udenafil ameliorates nonalcoholic fatty liver disease by improving mitochondrial function.

Biochem Biophys Res Commun 2021 Apr 22;558:57-63. Epub 2021 Apr 22.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Daejeon Eulji Medical Center, Eulji University, Daejeon, South Korea. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) refers to a series of diseases, including simple steatosis, caused by the excessive accumulation of fat in hepatocytes, nonalcoholic steatohepatitis with inflammation and fibrosis, and more advanced forms of cirrhosis. The pathogenic mechanisms underlying fatty liver and the progression from simple fatty liver to hepatitis and cirrhosis remain unclear. One potentially unifying mechanism may be a dysregulation of free fatty acid oxidation. Read More

View Article and Full-Text PDF

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease.

Biochem Pharmacol 2021 Apr 23;188:114582. Epub 2021 Apr 23.

Department of Toxicology, School of Public Health, Qingdao University, Qingdao, China. Electronic address:

Cytochrome P450 (CYP) enzymes play critical roles in drug transformation, and the total CYPs are markedly decreased in alcoholic hepatitis (AH), a fatal alcoholic liver disease. miRNAs are endogenous small noncoding RNAs that regulate many essential biological processes. Knowledge concerning miRNA regulation of CYPs in AH disease is limited. Read More

View Article and Full-Text PDF

Impact of alcohol on the progression of HCV-related liver disease: A systematic review and meta-analysis.

J Hepatol 2021 Apr 20. Epub 2021 Apr 20.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada, M5S 2S1; Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 1P8, Canada; World Health Organization / Pan American Health Organization Collaborating Centre, Centre for Addiction and Mental Health, 33 Ursula Franklin Street, Toronto, Ontario, Canada, M5S 2S1; Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246 Hamburg, Germany; Institute of Clinical Psychology and Psychotherapy & Center of Clinical Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Chemnitzer Str. 46, 01187 Dresden, Germany; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, Ontario, Canada, M5T 2S1; Faculty of Medicine, Institute of Medical Science, University of Toronto, Medical Sciences Building, 1 King's College Circle, Room 2374, Toronto, Ontario, Canada, M5S 1A8; Department of Psychiatry, University of Toronto, 250 College Street, 8th floor, Toronto, Ontario, Canada, M5T 1R8; Department of International Health Projects, Institute for Leadership and Health Management, I.M. Sechenov First Moscow State Medical University, Trubetskaya str., 8, b. 2, 119992, Moscow, Russian Federation. Electronic address:

Introduction: Despite a marked reduction in new cases of liver cirrhosis caused by hepatitis C virus (HCV) infection, over 500,000 new cirrhosis cases in this category were estimated globally in 2019. This contribution quantifies the relationship between alcohol use and the progression of liver disease in people with HCV infections.

Materials And Methods: The causal impact of different levels of alcohol use on liver cirrhosis has previously been established. Read More

View Article and Full-Text PDF

Examining the gut-liver axis in liver cancer using organoid models.

Cancer Lett 2021 Apr 20;510:48-58. Epub 2021 Apr 20.

Blacktown Clinical School, Western Sydney University, Blacktown, NSW, Australia; Storr Liver Centre, The Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia; Blacktown Hospital, Blacktown, NSW, Australia. Electronic address:

The World Health Organization predicts that by 2030 liver cancer will cause 1 million deaths annually, thus becoming the third most lethal cancer worldwide. Hepatocellular carcinoma and cholangiocarcinoma are the two major primary cancer subtypes involving the liver. Both are often diagnosed late, and hence response to treatment and survival are poor. Read More

View Article and Full-Text PDF

Non-alcoholic fatty liver disease is a risk factor for occurrence of hepatocellular carcinoma after sustained virologic response in chronic hepatitis C patients: A prospective four-years follow-up study.

Metabol Open 2021 Jun 26;10:100090. Epub 2021 Mar 26.

Department of Liver Diseases, Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, China.

Background And Aim: The incidence of hepatocellular carcinoma (HCC) decreases significantly in chronic hepatitis C (CHC) patients with sustained virologic response (SVR) after pegylated-interferon plus ribavirin (PR) or direct-acting antiviral (DAAs) therapy. We follow-up a single cohort of CHC patients to identify risk factors associated with HCC development post-SVR.

Method: CHC patients with SVR in Beijing/Hong Kong were followed up at 12-24 weekly intervals with surveillance for HCC by ultrasonography and alpha-fetoprotein (AFP). Read More

View Article and Full-Text PDF

Severe alcoholic hepatitis: Jumping from the frying pan into the fire.

United European Gastroenterol J 2021 Apr 22. Epub 2021 Apr 22.

Department of Gastroenterology, Centro Hospitalar Lisboa Ocidental, Hospital de Egas Moniz, Lisbon, Portugal.

View Article and Full-Text PDF

Letter: is the AHHS score really useful in clinically severe alcoholic hepatitis?

Aliment Pharmacol Ther 2021 May;53(10):1160-1161

Department of Digestive and Hepatobiliary Medecine, CHU Clermont-Ferrand, Clermont-Ferrand, France.

View Article and Full-Text PDF

Investigation of the therapeutic effect of Yinchen Wuling Powder on CCl-induced hepatic fibrosis in rats by H NMR and MS-based metabolomics analysis.

J Pharm Biomed Anal 2021 Apr 16;200:114073. Epub 2021 Apr 16.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang, Liaoning, China. Electronic address:

Hepatic fibrosis (HF) is a typical consequence of various chronic liver diseases, and there is still no ideal drug for its treatment. Yinchen Wuling Powder (YCWLP), a famous traditional Chinese medicine prescription, is effective for the treatment of icteric hepatitis, hepatic fibrosis, non-alcoholic fatty liver disease and other liver diseases in clinical practices, however, the underlying mechanisms of YCWLP on HF is still unclear. In this study, H NMR and MS-based metabolomics analysis along with body weight change, serum liver function indexes, serum liver fibrosis index and histopathological observations of liver were applied to evaluate the therapeutic effect of YCWLP on hepatic fibrosis and the mechanism associated with this. Read More

View Article and Full-Text PDF

Serum selenium and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2011-2016.

Environ Res 2021 Apr 16;197:111190. Epub 2021 Apr 16.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Background: Selenium is an essential trace element that shows beneficial or adverse health effects depending on the dose. Laboratory studies suggest that high selenium may contribute to the development of non-alcoholic fatty liver disease (NAFLD). However, human evidence is limited. Read More

View Article and Full-Text PDF

3D human liver spheroids for translational pharmacology and toxicology.

Basic Clin Pharmacol Toxicol 2021 Apr 19. Epub 2021 Apr 19.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Drug development is a failure-prone endeavour, and more than 85% of drugs fail during clinical development, showcasing that current preclinical systems for compound selection are clearly inadequate. Liver toxicity remains a major reason for safety failures. Furthermore, all efforts to develop pharmacological therapies for a variety of chronic liver diseases, such as non-alcoholic steatohepatitis (NASH) and fibrosis, remain unsuccessful. Read More

View Article and Full-Text PDF

Etiologies and outcomes of cirrhosis in a large contemporary cohort.

Scand J Gastroenterol 2021 Apr 19:1-6. Epub 2021 Apr 19.

Division of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden.

Background And Aims: Patients with liver cirrhosis have high mortality, often estimated by the Child-Pugh or MELD scores. Etiologies of cirrhosis are rapidly shifting, and it is unclear if these scores perform similarly across subgroups of patients. Here, we describe the characteristics and outcomes of a large contemporary cohort of patients with cirrhosis. Read More

View Article and Full-Text PDF

Analysis of Liver Microenvironment during Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish.

J Vis Exp 2021 Apr 1(170). Epub 2021 Apr 1.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine; Department of Medicine (Hepatology), Albert Einstein College of Medicine; Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine; Marion Bessin Liver Research Center, Albert Einstein College of Medicine;

Liver cancer is currently the third leading cause of cancer related death worldwide, and Hepatocellular Carcinoma (HCC) accounts for 75-90% of all liver cancer cases. With the introduction of effective treatments to prevent and treat hepatitis B/C, non-alcoholic fatty liver disease (NAFLD), and the more aggressive form know as non-alcoholic steatohepatitis (NASH), are quickly becoming the number one risk factors to develop HCC in modern societies. To better understand the role NASH has on the development of HCC we designed a NASH-associated HCC zebrafish. Read More

View Article and Full-Text PDF

Letter to the editor: "Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in Patients With Alcoholic Hepatitis".

Clin Gastroenterol Hepatol 2021 Apr 14. Epub 2021 Apr 14.

Department of Infectious Diseases, YiWu Central Hospital, Zhejiang, China.

View Article and Full-Text PDF

Clinical Presentation and Gene Expression of Acute Alcohol-Induced Microvesicular Steatosis Mimicking Alcoholic Hepatitis.

Hepatol Commun 2021 Apr 9;5(4):618-628. Epub 2021 Jan 9.

Gastroenterology and Hepatology University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland.

Acute alcoholic microvesicular steatosis (MIC) may complicate heavy alcohol intake and present as alcoholic hepatitis (AH) syndrome. However, detailed clinical, biological, and histologic data associated with MIC are scarce. We compared the clinical presentation, histologic features, and hepatic transcriptomic of patients presenting with AH due to either MIC or severe alcoholic steatohepatitis (ASH). Read More

View Article and Full-Text PDF

Intrahepatic distribution of nerve fibers and alterations due to fibrosis in diseased liver.

PLoS One 2021 14;16(4):e0249556. Epub 2021 Apr 14.

Department of Gastroenterology, Yamagata University Faculty of Medicine, Yamagata, Japan.

Autonomic nerve fibers in the liver are distributed along the portal tract, being involved in the regulation of blood flow, bile secretion and hepatic metabolism, thus contributing to systemic homeostasis. The present study investigated changes in hepatic nerve fibers in liver biopsy specimens from patients with normal liver, viral hepatitis and non-alcoholic steatohepatitis, in relation to clinical background. The areal ratio of nerve fibers to the total portal area was automatically calculated for each sample. Read More

View Article and Full-Text PDF

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.

Semin Immunopathol 2021 Apr 13. Epub 2021 Apr 13.

Section of Molecular Immunology und Gastroenterology, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.

The human liver fulfills several vital tasks daily and possesses an impressive ability to self-regenerate. However, the capacity of this self-healing process can be exhausted by a variety of different liver diseases, such as alcoholic liver damage, viral hepatitis, or hepatocellular carcinoma. Over time, all these diseases generally lead to progressive liver failure that can become fatal if left untreated. Read More

View Article and Full-Text PDF

Promyelocytic Leukemia Antigen Expression: a Histological Marker for Primary Biliary Cholangitis Diagnosis?

J Transl Int Med 2021 Mar 31;9(1):43-51. Epub 2021 Mar 31.

Department of Pathology, Medical School, University of Thessaly, 41110 Larissa, Greece.

Background And Objectives: Distinguishing primary biliary cholangitis (PBC) from other cholestatic diseases at the histological level could be assisted by new methods, such as immunohistochemical staining of specific antigens.

Methods: We evaluated whether the detection of promyelocytic leukemia protein (PML) can serve as a specific and sensitive marker for PBC diagnosis. Liver biopsies from 26 PBC patients, 20 primary sclerosing cholangitis (PSC), 37 viral hepatitis, 11 non-alcoholic steatohepatitis (NASH) and 5 normal patients were investigated after immunostaining with the anti-PML monoclonal PG-M3, IgG1 antibody. Read More

View Article and Full-Text PDF

Low serum alkaline phosphatase levels in patients with chronic liver diseases: Possible contributions to disease pathogenesis.

Clin Res Hepatol Gastroenterol 2021 Apr 10;45(4):101694. Epub 2021 Apr 10.

Section of Hepatology, Department of Medicine, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Pharmacology and Therapeutics, Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Objectives: A low serum alkaline phosphatase (ALP) level is an uncommon finding in patients with chronic liver disease (CLD). The prevalence of this finding and whether low ALP expression influences CLD remain to be determined. The objectives of this study were: (1) to document the prevalence of low serum ALP levels in adult CLD patients and (2) compare features of CLD in patients with low versus normal or elevated serum ALP levels. Read More

View Article and Full-Text PDF

Controlled Attenuation Parameter for Quantification of Steatosis: Which Cut-Offs to Use?

Can J Gastroenterol Hepatol 2021 26;2021:6662760. Epub 2021 Mar 26.

Department of Gastroenterology and Hepatology, Advanced Regional Research Center in Gastroenterology and Hepatology, "Victor Babeş" University of Medicine and Pharmacy, 156, Liviu Rebreanu Bv., Timişoara 300723, Romania.

Chronic liver diseases (CLDs) are a public health problem, even if frequently they are underdiagnosed. Hepatic steatosis (HS), encountered not only in nonalcoholic fatty liver disease (NAFLD) but also in chronic viral hepatitis, alcoholic liver disease, etc., plays an important role in fibrosis progression, regardless of CLD etiology; thus, detection and quantification of HS are imperative. Read More

View Article and Full-Text PDF

[Bacteriophage Therapy: Retrospective Review and Future Prospects].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):170-175

Department of Respiratory and Intensive Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

At present, bacterial infections are mainly treated with antibiotics, but new treatment methods are urgently needed because of growing problems with antibiotic resistance. Therefore, phage therapy will be a potential solution to the problem of bacterial drug resistance, and the combined use of bacteriophage and antibiotics is also considered a potential treatment option. However, there has not been any well-designed clinical controlled trials on phage therapy. Read More

View Article and Full-Text PDF

Efficacy and Safety of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycholic Acid Combination in Chronic Hepatitis Related to Metabolic Syndrome Components.

Korean J Gastroenterol 2021 04;77(4):179-189

Division of Gastroenterology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Backgrounds/aims: Steatohepatitis related to metabolic syndrome is a chronic liver disease prevalent in patients not only with non-alcoholic steatohepatitis but also with alcoholic liver disease and chronic viral hepatitis. On the other hand, there is limited data on the effects of hepatotonic agents in these patients. Therefore, this study evaluated the efficacy of a combined hepatotonic agent in this population. Read More

View Article and Full-Text PDF

Hospital- and Patient-Level Characteristics Associated With Unplanned Readmissions and In-Patient Mortality in Men and Women With Alcoholic Cardiomyopathy.

J Stud Alcohol Drugs 2021 Mar;82(2):257-268

Center for Research Development and Scholarship, Vanderbilt University School of Nursing, Nashville, Tennessee.

Objective: The aims of the study were to (a) determine rates of early, late, and overall 30-day all-cause readmission for women and men with the diagnosis of alcoholic cardiomyopathy (ACM), (b) examine hospital- and patient-level characteristics associated with the risk of readmission and how these factors differed by sex, and (c) examine the association between sex and in-patient mortality during readmission.

Method: We conducted a multi-year cross-sectional analysis of adult (≥18 years) inpatient hospitalizations in the United States. Descriptive statistics including frequencies and percentages were used to describe the study population, stratified by sex. Read More

View Article and Full-Text PDF

miRNA expression profiles in liver grafts of HCV and HIV/HCV-infected recipients, 6 months after liver transplantation.

J Med Virol 2021 Apr 5. Epub 2021 Apr 5.

Department of Medicine, Liver-Kidney Transplant Unit, University of Udine, Udine, Italy.

In hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infected patients, HIV enhances HCV replication and liver damage. Several microRNAs (miRNAs), active in pro-fibrotic and inflammatory pathways, have been implicated in the pathogenesis of this phenomenon. However, these miRNAs have been tested only in explanted cirrhotic livers, when the liver damage has become chronic and irreversible. Read More

View Article and Full-Text PDF