9,335 results match your criteria Alcoholic Hepatitis


Nonalcoholic Fatty Liver Disease and Alcoholic Liver Disease are Major Drivers of Liver Mortality in the United States.

Hepatol Commun 2020 Jun 4;4(6):890-903. Epub 2020 Apr 4.

Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA.

In the United States, chronic viral hepatitis B and C (CHB and CHC), nonalcoholic fatty liver disease (NAFLD), and alcohol-related liver disease (ALD) are the main causes of liver deaths attributable to hepatocellular carcinoma (HCC) and cirrhosis. Our aim was to assess the changes in the rates of mortality and years of potential life lost (YLL) for HCC and cirrhosis due to different liver diseases. We used multiple-cause mortality data (2007-2017) from the National Center for Health Statistics. Read More

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http://dx.doi.org/10.1002/hep4.1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262283PMC

Surveillance for Hepatocellular Carcinoma in Patients with Non-Alcoholic Fatty Liver Disease: Universal or Selective?

Cancers (Basel) 2020 May 31;12(6). Epub 2020 May 31.

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, IRCCS-Ospedale Policlinico San Martino, 16132 Genoa, Italy.

Hepatocellular carcinoma (HCC), the most frequent primary liver cancer, is the sixth most common cancer, the fourth leading cause of cancer-related deaths worldwide, and accounts globally for about 800,000 deaths/year. Early detection of HCC is of pivotal importance as it is associated with improved survival and the ability to apply curative treatments. Chronic liver diseases, and in particular cirrhosis, are the main risk factors for HCC, but the etiology of liver disease is rapidly changing due to improvements in the prevention and treatment of HBV (Hepatitis B virus) and HCV (Hepatitis C virus) infections and to the rising incidence of the metabolic syndrome, of which non-alcoholic fatty liver (NAFLD) is a manifestation. Read More

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http://dx.doi.org/10.3390/cancers12061422DOI Listing

Association between Non-Alcoholic Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study.

J Clin Med 2020 May 28;9(6). Epub 2020 May 28.

Department of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.

It is unclear whether the link between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) is mediated by common risk factors. We aimed to elucidate the association between NAFLD and CKD using propensity score (PS)-matched analysis. We assessed 3725 Japanese individuals, excluding those with hepatitis B or C infection and men and women who consumed >30 and >20 g/day of alcohol, respectively. Read More

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http://dx.doi.org/10.3390/jcm9061635DOI Listing

Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma.

Nutrients 2020 May 28;12(6). Epub 2020 May 28.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular carcinoma. As anti-viral treatment progresses, the impact of NAFLD is increasing. NAFLD can coexist with chronic viral hepatitis and exacerbate its progression. Read More

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http://dx.doi.org/10.3390/nu12061576DOI Listing

Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders.

Curr Opin Pharmacol 2020 May 29;53:45-54. Epub 2020 May 29.

Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, Perugia, Italy.

Bile acids are produced in the liver by the cholesterol breakdown and further metabolized by the intestinal microbiota to generate a group of chemically heterogeneous steroids that bind and activate a family of cells surface and nuclear receptors, collectively known as the bile acid-activated receptors (BARs). The two best characterized members of this family are the farnesoid-x-receptor (FXR) and G protein Bile Acid Receptor (GPBAR1). Both receptors are expressed by cells of innate immunity including liver-resident and intestinal-resident macrophages and monocytes-derived macrophages. Read More

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http://dx.doi.org/10.1016/j.coph.2020.04.008DOI Listing

The Differential Influence of Cold Ischemia Time on Outcome After Liver Transplantation for Different Indications-Who Is at Risk? A Collaborative Transplant Study Report.

Front Immunol 2020 12;11:892. Epub 2020 May 12.

Institute of Immunology, University Hospital Heidelberg, Heidelberg, Germany.

Despite increasing awareness of the negative impact of cold ischemia time (CIT) in liver transplantation, its precise influence in different subgroups of liver transplant recipients has not been analyzed in detail. This study aimed to identify liver transplant recipients with an unfavorable outcome due to prolonged cold ischemia. 40,288 adult liver transplantations, performed between 1998 and 2017 and reported to the Collaborative Transplant Study were analyzed. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235423PMC

Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care.

World J Gastroenterol 2020 May;26(18):2221-2231

Department of Gastroenterology, Monash Health, Clayton 3168, Victoria, Australia.

Background: Hepatic encephalopathy (HE) is a reversible neuropsychiatric complication of liver cirrhosis and occurs in up to 50% of cirrhotic patients. Studies examining the prognostic significance of HE are limited despite the high prevalence in cirrhosis.

Aim: To define the clinical outcomes of patients after an episode of HE treated with current standards-of-care. Read More

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http://dx.doi.org/10.3748/wjg.v26.i18.2221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235207PMC

Liquid Biopsy for the Diagnosis of Viral Hepatitis, Fatty Liver Steatosis, and Alcoholic Liver Diseases.

Int J Mol Sci 2020 May 25;21(10). Epub 2020 May 25.

Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

During the progression from hepatitis to fibrosis, cirrhosis, and liver failure, the accumulation of stressed/damaged hepatocyte elements associated with liver inflammation is critical. The causes of hepatocyte injuries include viral hepatitis infections, alcoholic hepatitis, and non-alcoholic fatty liver disease. Hepatocyte-derived extracellular vesicles (Hep-EVs) released from stressed/damaged hepatocytes are partly responsible for liver disease progression and liver damage because they activate non-parenchymal cells and infiltrate inflammatory cells within the liver, which are in turn are an important source of EVs. Read More

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http://dx.doi.org/10.3390/ijms21103732DOI Listing

Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease.

Clin Transl Gastroenterol 2020 Feb;11(2):e00116

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Objectives: To investigate whether blood total lysosomal acid lipase activity (BT-LAL) levels are uniquely associated with the noncirrhotic and cirrhotic stages of nonalcoholic fatty liver disease (NAFLD) and with protection from NAFLD in metabolically/genetically predisposed subjects and a normal liver. To clarify which enzyme-carrying circulating cells are involved in reduced BT-LAL of NAFLD.

Methods: In a cross-sectional study, BT-LAL was measured by a fluorigenic method in patients with NAFLD (n = 118), alcoholic (n = 116), and hepatitis C virus-related disease (n = 49), in 103 controls with normal liver and in 58 liver transplant recipients. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145031PMC
February 2020

Intensive care utilization in patients with end-stage liver disease: A population-based comparative study of cohorts with and without comorbid hepatocellular carcinoma in taiwan.

EClinicalMedicine 2020 May 20;22:100357. Epub 2020 May 20.

Cicely Saunders Institute of Palliative Care, Policy & Rehabilitation, King's College London, Address: Bessemer Road, London, SE5 9PJ, United Kingdom.

Background: End-of-life intensive care may be futile and can be a cause of distress to both patients and their families. This study aimed to understand the utilization of intensive care and its associated factors in patients with End-stage liver disease (ESLD) during terminal hospitalization.

Methods: Population-based retrospective cohort study using the National Health Institute Research Database of Taiwan. Read More

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http://dx.doi.org/10.1016/j.eclinm.2020.100357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240333PMC

Prognostic Value of the Alcoholic Hepatitis Histologic Score in Korean Patients with Biopsy-Proven Alcoholic Hepatitis.

Gut Liver 2020 May 29. Epub 2020 May 29.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Background/aims: The alcoholic hepatitis histologic score (AHHS) is a recently developed clinical model for predicting short-term mortality in Caucasian patients with alcoholic hepatitis (AH). The AHHS has not been extensively validated in other ethnic populations. This study validated the AHHS in a Korean patient cohort. Read More

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http://dx.doi.org/10.5009/gnl19203DOI Listing

Reuse of liver allograft from a brain-dead recipient: A case report.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):192-197

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

We report our first case of deceased-donor liver transplantation (LT) using a reuse liver graft after the first LT. The recipient was a 38-year-old female with fulminant hepatic failure from toxic hepatitis. She had a history of herb intake and her liver function deteriorated progressively. Read More

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http://dx.doi.org/10.14701/ahbps.2020.24.2.192DOI Listing

Propranolol Is Associated with Lower Risk of Incidence of Hepatocellular Carcinoma in Patients with Alcoholic Cirrhosis: A Tertiary-Center Study and Indirect Comparison with Meta-Analysis.

Gastroenterol Res Pract 2020 9;2020:1892584. Epub 2020 Apr 9.

Faculty of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Beitou District, Taipei City 112, Taiwan.

Alcoholic cirrhosis (AC) leads to enormous disease burden and occupies a substantial proportion in the etiology of hepatocellular carcinoma (HCC), but scarce attention has been paid to this topic. Besides, propranolol has been reported to decrease the rate of HCC in viral hepatitis. We conducted a retrospective tertiary-center cohort study to identify the HCC incidence in AC patients with or without propranolol. Read More

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http://dx.doi.org/10.1155/2020/1892584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238337PMC

Current status of liver transplantation in Europe.

Int J Surg 2020 May 23. Epub 2020 May 23.

Swiss HPB and Transplantation Center, Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland. Electronic address:

Liver transplantation (LT) in Europe became an established life-saving treatment for patients with end-stage liver disease, hepatocellular carcinoma, and acute liver conditions with life-threatening hepatic dysfunction. Although there are substantial disparities in donation and transplant rates among European countries, LT can be offered to almost every European citizen today. In order to maximize the LT benefit beyond national levels, many countries cooperate within transnational organizations including Eurotransplant, Scandiatransplant, and Southern Alliance for Transplantation. Read More

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http://dx.doi.org/10.1016/j.ijsu.2020.05.062DOI Listing

Omega-3 derivatives, specialized pro-resolving mediators: Promising therapeutic tools for the treatment of pain in chronic liver disease.

Prostaglandins Leukot Essent Fatty Acids 2020 May 17;158:102095. Epub 2020 May 17.

Centro de Investigaciones Medicas, Escuela de Medicina, Universidad de Talca, Talca, Chile. Electronic address:

The main causes of liver injury are associated with inflammation and permanent damage. They can cause chronic liver disease (CLD), which is mainly related to viral hepatitis, alcohol consumption and non-alcoholic steatohepatitis, leading to fibrosis, cirrhosis and hepatocellular carcinoma. These conditions prevent the liver from working normally and make it begin to fail, which in turn may prompt a liver transplant. Read More

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http://dx.doi.org/10.1016/j.plefa.2020.102095DOI Listing

Unexpected Improvement of Liver Function by Intravenous Immunoglobulin in a Steroid-Experienced Severe Alcoholic Hepatitis.

ACG Case Rep J 2020 Feb 2;7(2):e00337. Epub 2020 Mar 2.

Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Corticosteroid is the treatment of choice for severe alcoholic hepatitis; however, it can also lead to severe life-threatening infection. We report a 28-year-old severe alcoholic hepatitis patient who did not achieve a satisfactory improvement of the liver function by corticosteroid use but obtained a significant improvement of the liver function by intravenous immunoglobulin. Intravenous immunoglobulin was administered to control infection after prolonged corticosteroid usage; however, it led to an unexpected remarkable decrease in the serum total bilirubin level and restored the responsiveness to the additional corticosteroid used after the resolution of the infection. Read More

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http://dx.doi.org/10.14309/crj.0000000000000337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209802PMC
February 2020

Progressive Weakness and Encephalopathy in a 34-Year-Old Woman.

Clin Gastroenterol Hepatol 2020 May 8. Epub 2020 May 8.

Division of Gastroenterology, Department of Medicine. Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.cgh.2020.05.007DOI Listing

The Changing Burden of Alcoholic Hepatitis: Rising Incidence and Associations with Age, Gender, Race, and Geography.

Dig Dis Sci 2020 May 20. Epub 2020 May 20.

Division of Digestive Health and Liver Diseases, Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14th St, Room 807, Miami, FL, 33136, USA.

Alcoholic hepatitis is a major cause of morbidity and mortality. However, there are limited population-based data on its incidence, demographics, and temporal trends. We performed a retrospective cohort study using the State Inpatient Databases from Florida, Massachusetts, New York, and Washington from 2010 to 2014. Read More

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http://dx.doi.org/10.1007/s10620-020-06346-8DOI Listing

MiR-155 and MiR-665 Role as Potential Non-invasive Biomarkers for Hepatocellular Carcinoma in Egyptian Patients with Chronic Hepatitis C Virus Infection.

J Transl Int Med 2020 Mar 9;8(1):32-40. Epub 2020 May 9.

Clinical Oncology Department, Kasralainy, Cairo University, Cairo, Egypt.

Background And Objectives: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer associated death globally. Serum micro RNAs are full of potential as noninvasive biomarkers. Here, we aim to assess the performance of serum MicroRNA-155 and MicroRNA-665 as diagnostic biomarker for HCC comparing to AFP. Read More

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http://dx.doi.org/10.2478/jtim-2020-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227164PMC

A Pilot Study of Racial Differences in the Current Definition of Sarcopenia among Liver Transplant Candidates.

Hawaii J Health Soc Welf 2020 May;79(5):161-167

Transplant Center, The Queen's Medical Center, Honolulu, HI (LY-A, LLW).

Sarcopenia has been shown to have prognostic value in patients awaiting liver transplant. However, the presence of sarcopenia as a prognostic factor among patients awaiting liver transplantation might vary by race. This study aims to assess racial differences of sarcopenia in liver transplant candidates. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226313PMC

The liver in times of COVID-19: What hepatologists should know.

Ann Hepatol 2020 May 18. Epub 2020 May 18.

Latin American Liver Research, Educational and Awareness Network (LALREAN) Pilar, Provincia de Buenos Aires Argentina, Argentina.

The ongoing pandemic of coronavirus disease 2019 (COVID-19) pandemic poses a serious threat to healthcare systems globally. Information regarding to the how the infection affects the liver and relevance of pre-existing liver disease as a risk factor for acquiring the infection or having a severe disease are still scarce. Also, considerations to be considered in liver transplant patients or those having hepatocellular carcinoma or are under immunosuppressive therapy are being matter of analysis as information is being generated. Read More

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http://dx.doi.org/10.1016/j.aohep.2020.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233236PMC
May 2020
2.193 Impact Factor

Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats.

Front Pharmacol 2020 1;11:530. Epub 2020 May 1.

Centre Lab of Longhua Branch and Department of Infectious Disease, 2nd Clinical Medical College (Shenzhen People's Hospital) of Jinan University, Shenzhen, China.

Si-Wei-Qing-Gan-Tang (SWQGT) is a Chinese medicine formula that is widely used as a folk remedy of herbal tea for the treatment of chronic hepatitis, like non-alcoholic steatohepatitis (NASH), around Ganzhou City (Jiangxi province, China). However, the underlying mechanisms of this formula against NASH are still unknown. This study aimed to explore the effect and mechanisms of SWQGT against NASH. Read More

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http://dx.doi.org/10.3389/fphar.2020.00530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206618PMC

A Latin American survey on demographic aspects of hospitalized, decompensated cirrhotic patients and the resources for their management.

Ann Hepatol 2020 Apr 23. Epub 2020 Apr 23.

Gastroenterology Department, Hospital de la Samaritana, Bogotá, Colombia.

Introduction & Objectives: Liver cirrhosis is a major cause of mortality worldwide. Adequate diagnosis and treatment of decompensating events requires of both medical skills and updated technical resources. The objectives of this study were to search the demographic profile of hospitalized cirrhotic patients in a group of Latin American hospitals and the availability of expertise/facilities for the diagnosis and therapy of decompensation episodes. Read More

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http://dx.doi.org/10.1016/j.aohep.2020.03.007DOI Listing

Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study.

J Infect Dis 2020 May 16. Epub 2020 May 16.

Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre.

Background: People living with HIV (PWH) may be at risk of non-alcoholic fatty liver disease (NAFLD). We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with HIV-uninfected controls and determined risk factors for M-HS in PWH.

Methods: The Copenhagen Co-Morbidity in HIV infection Study included 453 participants and the Copenhagen General Population Study 765 participants. Read More

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http://dx.doi.org/10.1093/infdis/jiaa246DOI Listing

GSK-3 in liver diseases: Friend or foe?

Biochim Biophys Acta Mol Cell Res 2020 May 15;1867(9):118743. Epub 2020 May 15.

Institute for Biomedical Research and Innovation, National Research Council (CNR), Palermo, Italy. Electronic address:

Liver diseases, including hepatitis due to hepatitis B or C virus infection, non-alcoholic fatty liver disease, and hepatocellular carcinoma pose major challenges for overall health due to limited curative treatment options. Thus, there is an urgent need to develop new therapeutic strategies for the treatment of these diseases. A better understanding of the signaling pathways involved in the pathogenesis of liver diseases can help to improve the efficacy of emerging therapies, mainly based on pharmacological approaches, which influence one or more specific molecules involved in key signal transduction pathways. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118743DOI Listing

Spatial expression of glucagon-like peptide 1 receptor and caveolin-1 in hepatocytes with macrovesicular steatosis in non-alcoholic steatohepatitis.

BMJ Open Gastroenterol 2020 May;7(1)

Department of Clinical Pharmacy, Kitasato University School of Pharmacy, Minato-ku, Tokyo, Japan.

Objective: Non-alcoholic steatohepatitis (NASH) can progress to fibrosis, cirrhosis and end-stage liver disease. Glucagon-like peptide 1 receptor (GLP-1R) mediates β cell function. Its receptor agonists, currently used to treat type 2 diabetes mellitus, might be effective against NASH. Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232783PMC

Albumin binding function is a novel biomarker for early liver damage and disease progression in non-alcoholic fatty liver disease.

Endocrine 2020 May 12. Epub 2020 May 12.

Department of Liver Surgery, Peking Union Medical College (PUMC) Hospital, PUMC & Chinese Academy of Medical Sciences, 100730, Beijing, China.

Purpose: Indicators to assess early liver damage and disease progression in nonalcoholic fatty liver disease (NAFLD) remain unsatisfactory. Albumin binding function has been reported to be an early indicator of liver damage in hepatitis and liver cirrhosis. However, its role in NAFLD patients is unknown. Read More

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http://dx.doi.org/10.1007/s12020-020-02319-zDOI Listing

Extracellular vesicle-associated soluble CD163 and CD206 in patients with acute and chronic inflammatory liver disease.

Scand J Gastroenterol 2020 May 12:1-9. Epub 2020 May 12.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Extracellular vesicles (EVs) are implicated in intercellular communication in liver diseases. An EV-associated fraction of the macrophage biomarker soluble CD163, denoted EV-CD163, was recently identified. EV-CD163 may be released during later phases of the inflammatory response as opposed to the acute shedding of CD163 ectodomain (Ecto-CD163). Read More

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http://dx.doi.org/10.1080/00365521.2020.1759140DOI Listing

Population-based study of autoimmune hepatitis and primary biliary cholangitis in Germany: rising prevalences based on ICD codes, yet deficits in medical treatment.

Z Gastroenterol 2020 May 11;58(5):431-438. Epub 2020 May 11.

Techniker Krankenkasse, Hamburg, Germany.

Background:  Population-based data on the prevalence of and real-life treatment for the autoimmune liver diseases (AILD), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), are scarce, and such knowledge may help to improve patient care.

Methods:  Data of 8.1 million individuals having health insurance with the "Techniker Krankenkasse," the largest German health insurer, were analyzed with regard to the prevalence of and prescribed medication for AILD in Germany from 2011 until 2014. Read More

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http://dx.doi.org/10.1055/a-1135-9306DOI Listing

Hepatic manifestations in systemic lupus erythematosus.

Lupus 2020 May 9:961203320923398. Epub 2020 May 9.

Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Systemic lupus erythematosus (SLE) is a multi-organic autoimmune disease with a wide variety of clinical manifestations. However, hepatic dysfunction is not included in the diagnostic criteria for the disease and has not been recognized properly. The spectrum of hepatic involvement described in these patients ranges from abnormalities in liver function tests (LFTs) to fulminant hepatic failure. Read More

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http://dx.doi.org/10.1177/0961203320923398DOI Listing

Impact of Type 2 Diabetes on Oncologic Outcomes of Hepatocellular Carcinomas in Non-Cirrhotic, Non-alcoholic Steatohepatitis: a Matched-Pair Analysis.

J Gastrointest Surg 2020 May 6. Epub 2020 May 6.

Department of General-, Visceral- and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Background: Non-alcoholic steatohepatitis (NASH) associated hepatocellular carcinomas (NASH-HCC) are increasing. NASH-HCC often develops in the fibrotic liver. Several analyses report conflicting results regarding the outcome of non-cirrhotic NASH-HCC. Read More

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http://dx.doi.org/10.1007/s11605-020-04628-0DOI Listing

Oncogenic driver genes and tumor microenvironment determine the type of liver cancer.

Cell Death Dis 2020 May 4;11(5):313. Epub 2020 May 4.

Department of General Surgery, Tangdu Hospital, Air Force Military Medical University, Xi'an, 710032, Shaanxi, China.

Primary liver cancer (PLC) may be mainly classified as the following four types: hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma (HB), and combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma (cHCC-ICC). The majority of PLC develops in the background of tumor microenvironment, such as inflammatory microenvironments caused by viral hepatitis, alcoholic or nonalcoholic steatohepatitis, carbon tetrachloride (CCl), 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), and necroptosis-associated hepatic cytokine microenvironment caused by necroptosis of hepatocytes. However, the impact of different types of microenvironments on the phenotypes of PLC generated by distinct oncogenes is still unclear. Read More

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http://dx.doi.org/10.1038/s41419-020-2509-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198508PMC
May 2020
5.014 Impact Factor

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages.

J Hepatol 2020 Apr 29. Epub 2020 Apr 29.

Department of Medicine III, University Hospital Aachen, Aachen, Germany; Department of Hepatology and Gastroenterology, Charité University Medicine Berlin, Berlin, Germany. Electronic address:

Background And Aims: Peroxisome proliferator-activated receptors (PPARs) are essential regulators of whole-body metabolism, but also modulate inflammation in immune cells, notably macrophages. We compared selective PPAR agonists with the pan-PPAR agonist lanifibranor as therapeutic agents in non-alcoholic fatty liver disease (NAFLD), and determined isoform-specific effects on hepatic macrophage biology.

Methods: Lanifibranor or selective PPARα (fenofibrate), PPARγ (pioglitazone) and PPARδ (GW501516) agonists were therapeutically administered in choline-deficient, amino acid-defined high-fat diet-induced (CDAA-HFD) and Western diet (WD) mouse NAFLD models. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.04.025DOI Listing

High risk of non-alcoholic liver disease mortality in patients with chronic hepatitis C with illicit substance use disorder.

Scand J Gastroenterol 2020 May 1:1-7. Epub 2020 May 1.

AbbVie AB, Stockholm, Sweden.

Hepatitis C virus (HCV) is a slowly progressive disease, often transmitted among people who inject drugs (PWID). Mortality in PWID is high, with an overrepresentation of drug-related causes. This study investigated the risk of death in patients with chronic hepatitis C virus (HCV) infection with or without illicit substance use disorder (ISUD). Read More

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http://dx.doi.org/10.1080/00365521.2020.1754456DOI Listing

Distinctive Features and Outcomes of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Disease: A US Multicenter Study.

Clin Transl Gastroenterol 2020 Mar;11(3):e00139

Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Introduction: The burden of hepatocellular carcinoma (HCC) occurring in patients with alcoholic liver disease (ALD) is increasing at an alarming rate. The aims of this study were to compare the patient and tumor characteristics of HCC occurring in ALD-alone relative to and in addition to other chronic liver diseases.

Methods: Patients diagnosed with HCC between 2000 and 2014 were identified at 5 US clinical centers. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145044PMC

High incidence of hepatocellular carcinoma and cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study.

BMC Gastroenterol 2020 Apr 29;20(1):128. Epub 2020 Apr 29.

Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, China.

Background: Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. We aimed to study the incidence of hepatocellular carcinoma (HCC) and cirrhotic complications in psychiatric patients.

Methods: We identified consecutive adult patients in all public hospitals and clinics in Hong Kong with psychiatric diagnoses between year 2003 and 2007 using the Clinical Data Analysis and Reporting System, which represents in-patient and out-patient data of approximately 80% of the 7. Read More

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http://dx.doi.org/10.1186/s12876-020-01277-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189713PMC

Expanding Indications of Liver Transplantation in Spain: Consensus Statement and Recommendations by the Spanish Society of Liver Transplantation.

Transplantation 2020 Apr 27. Epub 2020 Apr 27.

Department of Hepatology and Liver Transplantation. Hospital Clínic de Barcelona, IBIBAPS, CIBERehd. SETH Scientific Committee.

Background: The number of patients awaiting liver transplantation (LT) in Spain has halved from 2015 to 2019 due to the reduction of candidates with hepatitis C and the successful implementation of non-heart beating donation programs across the country. The Spanish Society for Liver Transplantation (SETH) has committed to take advantage of this situation by developing consensus around potential areas to expand the current indications for LT. The consensus group was composed of 6 coordinators and 23 expert delegates, each one representing a LT institution in Spain. Read More

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http://dx.doi.org/10.1097/TP.0000000000003281DOI Listing

Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar-associated protein 4.

Liver Int 2020 Apr 27. Epub 2020 Apr 27.

Department of Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark.

Background: Alcoholic liver disease (ALD) is a public health concern that is the cause of half of all cirrhosis-related deaths. Early detection of fibrosis, ideally in the precirrhotic stage, is a key strategy for improving ALD outcomes and for preventing progression to cirrhosis. Previous studies identified the blood-borne marker human microfibrillar-associated protein 4 (MFAP4) as a biomarker for detection of hepatitis C virus (HCV)-related fibrosis. Read More

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http://dx.doi.org/10.1111/liv.14491DOI Listing

Metabolic profiles and fibrosis of non-alcoholic fatty liver disease in the elderly: A community-based study.

J Gastroenterol Hepatol 2020 Apr 24. Epub 2020 Apr 24.

Department of Family Medicine, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan.

Background And Aims: There are sparse data on the epidemiology of fatty liver in the elderly Asian population. We evaluated for predictors of fatty liver and high risk of advanced fibrosis in a community-based elderly population.

Methods: A total of 1091 participants (mean age was 74. Read More

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http://dx.doi.org/10.1111/jgh.15073DOI Listing

Occult hepatitis B virus infection predicts non-alcoholic steatohepatitis in severely obese individuals from Italy.

Liver Int 2020 Apr 24. Epub 2020 Apr 24.

Unit of Clinical and Molecular Hepatology, University Hospital of Messina, Messina, Italy.

Background & Aims: Obesity is associated with non-alcoholic fatty liver (NAFL), which may progress towards non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Occult hepatitis B virus infection (OBI) may contribute to hepatic damage in patients with chronic liver disease of different aetiologies (eg HCV, alcohol). However, information on the prevalence and clinical impact of OBI in obese individuals is lacking. Read More

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http://dx.doi.org/10.1111/liv.14473DOI Listing

Burden of Alcoholic Liver Disease in a Tertiary Care Center: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2019 Sep-Oct;57(219):307-310

Department of Biochemistry, Nobel Medical College and Teaching Hospital, Biratnagar, Nepal.

Introduction: Alcoholic liver disease is a serious health problem related to an unhealthy lifestyle. The three most widely recognized forms of alcoholic liver disease are alcoholic fatty liver, acute alcoholic hepatitis, and alcoholic cirrhosis. The main aim of our study is to find out the prevalence of alcoholic liver disease in tertiary care center. Read More

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Comorbidities and Outcome of Alcoholic and Non-Alcoholic Liver Cirrhosis in Taiwan: A Population-Based Study.

Int J Environ Res Public Health 2020 Apr 20;17(8). Epub 2020 Apr 20.

Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan.

The prognosis of different etiologies of liver cirrhosis (LC) is not well understood. Previous studies performed on alcoholic LC-dominated cohorts have demonstrated a few conflicting results. We aimed to compare the outcome and the effect of comorbidities on survival between alcoholic and non-alcoholic LC in a viral hepatitis-dominated LC cohort. Read More

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http://dx.doi.org/10.3390/ijerph17082825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215882PMC

Serum Transferrin Is an Independent Predictor of Mortality in Severe Alcoholic Hepatitis: Upping the Game or Just Upping the Ante?

Am J Gastroenterol 2020 Apr 23. Epub 2020 Apr 23.

Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.14309/ajg.0000000000000657DOI Listing

Omics-derived hepatocellular carcinoma risk biomarkers for precision care of chronic liver diseases.

Hepatol Res 2020 Apr 22. Epub 2020 Apr 22.

Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Precise hepatocellular carcinoma (HCC) risk prediction will play increasingly important roles with the contemporary HCC etiologies, that is, non-alcoholic fatty liver disease and resolved hepatitis C virus infection. Because the HCC incidence rate in this emerging patient population is relatively low (~1% per year), identification of a subset of patients at the highest risk is critical to concentrate the effort and resources of regular HCC screening to those who most need it. Omics profiling has been derived using several candidate HCC risk biomarkers, which could refine HCC screening by enabling individual risk-based personalized or risk-stratified patient management. Read More

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http://dx.doi.org/10.1111/hepr.13506DOI Listing

The PNPLA3 rs738409 GG genotype is associated with poorer prognosis in 239 patients with autoimmune hepatitis.

Aliment Pharmacol Ther 2020 Jun 22;51(11):1160-1168. Epub 2020 Apr 22.

Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.

Background: Fibrosis progression in autoimmune hepatitis can be attenuated by immunosuppressive treatment; however, some patients progress despite therapy. Single nucleotide polymorphisms (SNPs) such as PNPLA3-rs738409, TM6SF2-rs58542926 and MBOAT7-rs641738 are associated with non-alcoholic fatty liver disease and fibrosis progression, whereas a splice variant in HSD17B13-rs72613567:TA has been shown to be protective.

Aim: To analyse the impact of different SNPs on the long-term outcome of patients with autoimmune hepatitis. Read More

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http://dx.doi.org/10.1111/apt.15722DOI Listing

Gut Microbiota and Liver Injury (II): Chronic Liver Injury.

Adv Exp Med Biol 2020 ;1238:39-54

Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, USA.

Chronic liver injury mainly comprises viral hepatitis, fatty liver disease, autoimmune hepatitis, cirrhosis and liver cancer. It is well established that gut microbiota serves as the key upstream modulator for chronic liver injury progression. Indeed, the term "gut-liver axis" was mostly applied for chronic liver injury. Read More

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http://dx.doi.org/10.1007/978-981-15-2385-4_4DOI Listing
January 2020

Seroprevalence and risk factors of hepatitis B and C viruses among diabetes mellitus patients in Duhok province, Iraqi Kurdistan.

Authors:
Muayad A Merza

J Family Med Prim Care 2020 Feb 28;9(2):642-646. Epub 2020 Feb 28.

Department of Clinical Pharmacy, College of Pharmacy, University of Duhok, Duhok, Kurdistan Region, Iraq.

Context: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major public health issues as they may progress into chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC).

Aims: to identify the prevalence and risk factors of HBV and HCV among diabetic patients in Duhok province.

Patients And Methods: It is a prospective study conducted in Shilan private hospital from June 2016 until December 2018. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_1158_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114067PMC
February 2020

microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis the MAPK Signaling Pathway Through Targeting SOCS1.

Front Pharmacol 2020 7;11:270. Epub 2020 Apr 7.

Department of Imaging, Linyi People's Hospital, Linyi, China.

The aim of this study was to investigate the regulatory function of the non-coding microRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS1) in alcoholic hepatitis (AH) and its potential mechanism associated with the mitogen-activated protein kinase (MAPK) signaling pathway. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), total bilirubin (TBIL), malondialdehyde (MDA), and superoxide dismutase (SOD) were measured in a rat model of AH. The biological prediction website microRNA. Read More

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http://dx.doi.org/10.3389/fphar.2020.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154100PMC

Splenic infarction in alcoholic hepatitis.

Proc (Bayl Univ Med Cent) 2020 Apr 30;33(2):239-240. Epub 2020 Jan 30.

Department of General Internal Medicine, University of MarylandBaltimoreMaryland.

Splenic infarctions have been reported in cirrhotic patients with comorbidities (e.g., primary biliary cirrhosis), but there is little to no mention of spontaneous splenic infarction in alcoholic hepatitis. Read More

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http://dx.doi.org/10.1080/08998280.2020.1719785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155995PMC